TWI688390B - 化合物、組合物及用於治療疾病之方法 - Google Patents

化合物、組合物及用於治療疾病之方法 Download PDF

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TWI688390B
TWI688390B TW107130548A TW107130548A TWI688390B TW I688390 B TWI688390 B TW I688390B TW 107130548 A TW107130548 A TW 107130548A TW 107130548 A TW107130548 A TW 107130548A TW I688390 B TWI688390 B TW I688390B
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alkyl
compound
aryl
heteroaryl
virus
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TW107130548A
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TW201919651A (zh
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安珍妮尤路 希里
吉塔 米賀
斯理魯帕 查拉
勝華 周
拉德哈克里西南 P 埃伊爾
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美商史貝羅威生物科學有限公司
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
    • C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
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    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
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    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
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    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
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TW107130548A 2017-08-31 2018-08-31 化合物、組合物及用於治療疾病之方法 TWI688390B (zh)

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US201762552473P 2017-08-31 2017-08-31
US62/552,473 2017-08-31
US201862664493P 2018-04-30 2018-04-30
US62/664,493 2018-04-30

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US (1) US11638716B2 (enExample)
EP (1) EP3675859A4 (enExample)
JP (2) JP7270608B2 (enExample)
TW (1) TWI688390B (enExample)
WO (1) WO2019046511A1 (enExample)

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