TWI666219B - 使用免疫球蛋白片段之位點專一性ｇｌｐ－２接合物 - Google Patents
使用免疫球蛋白片段之位點專一性ｇｌｐ－２接合物 Download PDFInfo
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- TWI666219B TWI666219B TW101150930A TW101150930A TWI666219B TW I666219 B TWI666219 B TW I666219B TW 101150930 A TW101150930 A TW 101150930A TW 101150930 A TW101150930 A TW 101150930A TW I666219 B TWI666219 B TW I666219B
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- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| AR090281A1 (es) * | 2012-03-08 | 2014-10-29 | Hanmi Science Co Ltd | Proceso mejorado para la preparacion de un complejo polipeptidico fisiologicamente activo |
| US9949927B2 (en) | 2012-04-10 | 2018-04-24 | The Regents Of The University Of California | Bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| WO2015042252A1 (en) * | 2013-09-19 | 2015-03-26 | The Regents Of The University Of California | Methods of treatment using bis-polymer lipid-peptide conjugates and nanoparticles thereof |
| US9994616B2 (en) | 2013-10-15 | 2018-06-12 | The University Of Tokyo | c-Met protein agonist |
| AU2014364589B2 (en) * | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| AU2015242657B2 (en) * | 2014-03-31 | 2020-05-21 | Hanmi Pharm. Co., Ltd. | Method for improving solubility of protein and peptide by using immunoglobulin Fc fragment linkage |
| KR101825048B1 (ko) * | 2014-12-31 | 2018-02-05 | 주식회사 제넥신 | GLP 및 면역글로불린 하이브리드 Fc 융합 폴리펩타이드 및 이의 용도 |
| MY206271A (en) | 2016-07-11 | 2024-12-06 | Opko Biologics Ltd | Long-acting coagulation factor vii and methods of producing same |
| CN107987170B (zh) * | 2016-10-27 | 2018-12-18 | 浙江道尔生物科技有限公司 | 一种用于治疗肠道疾病的融合蛋白 |
| US10925930B2 (en) | 2017-02-27 | 2021-02-23 | Urigen N.A. | Treatment of lower urinary tract epithelium with glucagon like peptide 2 |
| KR102174436B1 (ko) * | 2017-08-17 | 2020-11-04 | 주식회사 엘지화학 | 불용성 안료 화합물의 정성분석방법 |
| US20200199192A1 (en) | 2017-08-22 | 2020-06-25 | Shire-Nps Pharmaceuticals, Inc. | Glp-2 fusion polypeptides and uses for treating and preventing gastrointestinal conditions |
| CA3084326A1 (en) * | 2017-09-28 | 2019-04-04 | Jaehyuk Choi | Long-acting conjugates of glp-2 derivatives |
| US11660328B2 (en) * | 2017-11-06 | 2023-05-30 | Takeda Pharmaceutical Company Limited | GLP-2 analogs and peptibodies for administration before, during or after surgery |
| JP2022512688A (ja) * | 2018-10-24 | 2022-02-07 | シャイア－エヌピーエス ファーマシューティカルズ インコーポレイテッド | Ｇｌｐ－２融合ポリペプチドならびに消化管の状態の処置および予防のための使用 |
| EP3924369A1 (en) * | 2019-02-11 | 2021-12-22 | OPKO Biologics Ltd. | Long-acting glp-2 analogs |
| WO2020198604A1 (en) * | 2019-03-28 | 2020-10-01 | United States Government As Represented By The Department Of Veterans Affairs | Compositions and methods of treating and preventing systemic complications of acute illness |
| AU2020397917A1 (en) | 2019-12-04 | 2022-06-23 | The Scripps Research Institute | GLP2 receptor agonists and methods of use |
| JP7846622B2 (ja) * | 2019-12-24 | 2026-04-15 | ハンミ ファーマシューティカル カンパニー リミテッド | Ｇｌｐ－２又はその結合体を含む、代謝性骨疾患の予防又は治療用薬学的組成物 |
| EP4144361A4 (en) * | 2020-04-03 | 2024-05-22 | Hanmi Pharm. Co., Ltd. | PHARMACEUTICAL COMPOSITION FOR THE PREVENTION OR TREATMENT OF MUCOSITIS INDUCED BY RADIOTHERAPY, CHEMOTHERAPY OR A COMBINATION THEREOF, WITH GLP-2 DERIVATIVES OR LONG-ACTING CONJUGATE THEREOF |
| EP4154869A4 (en) * | 2020-05-22 | 2025-01-22 | Hanmi Pharm. Co., Ltd. | Liquid formulation of long-acting conjugate of glp-2 |
| CN111560062A (zh) * | 2020-05-26 | 2020-08-21 | 成都圣诺生物制药有限公司 | 一种Elisiglutide的制备方法 |
| WO2022159555A1 (en) * | 2021-01-20 | 2022-07-28 | The Trustees Of Columbia University In The City Of New York | Methods for treating graft-versus-host disease using glp-2 agonists and analogues thereof |
| MX2023014771A (es) | 2021-06-09 | 2024-03-19 | Scripps Research Inst | Conjugados peptidicos duales gip/glp-1 de accion prolongada y metodos de uso. |
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| WO2010107256A2 (en) * | 2009-03-20 | 2010-09-23 | Hanmi Pharm. Co., Ltd. | Method for preparing a site-specific physiologically active polypeptide conjugate |
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| JP4046354B2 (ja) | 1996-03-18 | 2008-02-13 | ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム | 増大した半減期を有する免疫グロブリン様ドメイン |
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| US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
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| ATE396202T1 (de) | 2001-02-16 | 2008-06-15 | Conjuchem Biotechnologies Inc | Lang wirkendes glucagon-ähnliches peptid-2 für die behandlung von gastrointestinalen krankheiten und störungen |
| CN1705681A (zh) * | 2002-10-14 | 2005-12-07 | 诺沃挪第克公司 | Glp－2化合物、制剂及其用途 |
| US20070060512A1 (en) * | 2003-03-04 | 2007-03-15 | Homayoun Sadeghi | Dipeptidyl-peptidase protected protein |
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2011
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| WO2010107256A2 (en) * | 2009-03-20 | 2010-09-23 | Hanmi Pharm. Co., Ltd. | Method for preparing a site-specific physiologically active polypeptide conjugate |
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Also Published As
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| EP2797621A4 (en) | 2015-09-02 |
| JP6131490B2 (ja) | 2017-05-24 |
| ES2725805T3 (es) | 2019-09-27 |
| CN109810198B (zh) | 2023-06-06 |
| EP2797621A1 (en) | 2014-11-05 |
| TW201333032A (zh) | 2013-08-16 |
| CN104144697A (zh) | 2014-11-12 |
| JP2015503554A (ja) | 2015-02-02 |
| CN109810198A (zh) | 2019-05-28 |
| KR20130078634A (ko) | 2013-07-10 |
| AR089506A1 (es) | 2014-08-27 |
| US20140377290A1 (en) | 2014-12-25 |
| WO2013100704A1 (en) | 2013-07-04 |
| US9504757B2 (en) | 2016-11-29 |
| KR101895047B1 (ko) | 2018-09-06 |
| EP2797621B1 (en) | 2019-03-06 |
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| Publication | Publication Date | Title |
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