TWI648063B - 用於免疫以對抗艱難梭菌（Ｃ. difficile）之組合物及方法 - Google Patents
用於免疫以對抗艱難梭菌（Ｃ. difficile）之組合物及方法 Download PDFInfo
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- TWI648063B TWI648063B TW103120772A TW103120772A TWI648063B TW I648063 B TWI648063 B TW I648063B TW 103120772 A TW103120772 A TW 103120772A TW 103120772 A TW103120772 A TW 103120772A TW I648063 B TWI648063 B TW I648063B
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- toxoid
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- difficile
- toxin
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- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
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| US201361835246P | 2013-06-14 | 2013-06-14 | |
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| BR122016023101B1 (pt) | 2012-10-21 | 2022-03-22 | Pfizer Inc | Polipeptídeo, composição imunogênica que o compreende, bem como célula recombinante derivada de clostridium difficile |
| US9730994B2 (en) | 2013-06-14 | 2017-08-15 | Sanofi Pasteur, Inc. | Compositions and methods for immunizing against C. difficile |
| US10676723B2 (en) | 2015-05-11 | 2020-06-09 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
| MX2020003756A (es) * | 2017-09-28 | 2020-07-29 | Pfizer | Composiciones y metodos para obtener una respuesta inmune contra clostridium difficile. |
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| US5071759A (en) | 1986-05-30 | 1991-12-10 | The United States Of America As Represented By The Secretary Of The Army | Hybridoma cell lines and monoclonal antibodies to clostridum difficile toxins A and B |
| DE69829400T2 (de) | 1997-10-20 | 2006-04-13 | Acambis, Inc., Cambridge | Passive immunisierung gegen durch clostridium difficile verursachte krankheit |
| US6969520B2 (en) | 1997-10-20 | 2005-11-29 | Acambis Inc. | Active immunization against clostridium difficile disease |
| CN106039299A (zh) | 2007-09-14 | 2016-10-26 | 赛诺菲巴斯德生物制剂有限责任公司 | 含艰难梭菌类毒素a和b的药物组合物 |
| GB0921288D0 (en) | 2009-12-04 | 2010-01-20 | Health Prot Agency | Therapies for preventing or suppressing clostridium difficile infection |
| JP5917682B2 (ja) | 2011-04-22 | 2016-05-18 | ワイス・エルエルシー | 変異体クロストリジウム・ディフィシル毒素に関する組成物およびその方法 |
| AR089797A1 (es) | 2012-01-27 | 2014-09-17 | Merck Sharp & Dohme | Vacunas contra clostridum difficile que comprenden toxinas recombinantes |
| GB201206070D0 (en) | 2012-04-04 | 2012-05-16 | Health Prot Agency | Clostridium difficile antigens |
| WO2014144567A2 (en) * | 2013-03-15 | 2014-09-18 | Sanofi Pasteur, Inc. | Toxoid, compositions and related methods |
| SG11201507578PA (en) * | 2013-03-15 | 2015-10-29 | Sanofi Pasteur Inc | Toxoid, compositions and related methods |
| US9730994B2 (en) | 2013-06-14 | 2017-08-15 | Sanofi Pasteur, Inc. | Compositions and methods for immunizing against C. difficile |
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2021
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Non-Patent Citations (2)
| Title |
|---|
| Greenberg, Richard N., et al. "Phase I dose finding studies of an adjuvanted Clostridium difficile toxoid vaccine." Vaccine 30.13 (2012): 2245-2249. * |
| Kotloff, Karen L., et al. "Safety and Immunogenicity of Increasing Doses of a Clostridium difficile Toxoid Vaccine Administered to Healthy Adults." Infection and immunity 69.2 (2001): 988-995. * |
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| CN105611942A (zh) | 2016-05-25 |
| EP3007724A1 (en) | 2016-04-20 |
| TW201536314A (zh) | 2015-10-01 |
| WO2014201346A1 (en) | 2014-12-18 |
| BR112015031088A2 (pt) | 2017-07-25 |
| US20210145956A1 (en) | 2021-05-20 |
| MX2015017257A (es) | 2016-11-11 |
| JP6691477B2 (ja) | 2020-04-28 |
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| US20160120968A1 (en) | 2016-05-05 |
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| AU2014277981A1 (en) | 2016-01-07 |
| SG11201510166YA (en) | 2016-01-28 |
| KR20160020543A (ko) | 2016-02-23 |
| US11419930B2 (en) | 2022-08-23 |
| US20200113991A1 (en) | 2020-04-16 |
| US9730994B2 (en) | 2017-08-15 |
| US20170304423A1 (en) | 2017-10-26 |
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