TWI609886B - 抗體、產生該抗體之融合瘤、包含該抗體之藥學組成物及其用途 - Google Patents
抗體、產生該抗體之融合瘤、包含該抗體之藥學組成物及其用途 Download PDFInfo
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- XETCRXVKJHBPMK-MJSODCSWSA-N trehalose 6,6'-dimycolate Chemical compound C([C@@H]1[C@H]([C@H](O)[C@@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](COC(=O)C(CCCCCCCCCCC3C(C3)CCCCCCCCCCCCCCCCCC)C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)O2)O)O1)O)OC(=O)C(C(O)CCCCCCCCCCCCCCCCCCCCCCCCC)CCCCCCCCCCC1CC1CCCCCCCCCCCCCCCCCC XETCRXVKJHBPMK-MJSODCSWSA-N 0.000 description 1
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Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3015—Breast
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/303—Liver or Pancreas
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
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- C07K—PEPTIDES
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/72—Increased effector function due to an Fc-modification
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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Landscapes
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| AU2015231256A1 (en) | 2014-03-19 | 2016-09-22 | Mackay Medical Foundation The Presbyterian Church In Taiwan Mackay Memorial Hospital | Antibodies against immunogenic glycopeptides, composition comprising the same and use thereof |
| CN106456727B (zh) | 2014-04-10 | 2020-11-27 | 台湾浩鼎生技股份有限公司 | 抗体、产生所述抗体的杂交瘤、及其用途 |
| HK1256912A1 (zh) | 2015-09-04 | 2019-10-04 | 台湾浩鼎生技股份有限公司 | 聚糖阵列以及使用方法 |
| AR106307A1 (es) | 2015-10-07 | 2018-01-03 | Obi Pharma Inc | Anticuerpos de hidratos de carbono, composiciones farmacéuticas y usos de los mismos |
| US10980894B2 (en) | 2016-03-29 | 2021-04-20 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| US11041017B2 (en) | 2016-03-29 | 2021-06-22 | Obi Pharma, Inc. | Antibodies, pharmaceutical compositions and methods |
| EP3445395A4 (en) | 2016-04-22 | 2019-12-25 | OBI Pharma, Inc. | CANCER IMMUNOTHERAPY BY MEANING OR IMMUNULATING VIA ANTIGENS OF THE GLOBO SERIES |
| GB201612317D0 (en) | 2016-07-15 | 2016-08-31 | Philogen Spa | Antibody compositions |
| KR20190067765A (ko) | 2016-07-27 | 2019-06-17 | 오비아이 파머 인코퍼레이티드 | 면역원성/치료 글리칸 조성물 및 그의 용도 |
| EP3491026A4 (en) | 2016-07-29 | 2020-07-29 | OBI Pharma, Inc. | HUMAN ANTIBODIES, PHARMACEUTICAL COMPOSITIONS AND METHODS |
| CA3044274A1 (en) * | 2016-11-21 | 2018-05-24 | Obi Pharma, Inc. | Conjugated biological molecules, pharmaceutical compositions and methods |
| US10781265B2 (en) * | 2017-05-24 | 2020-09-22 | Development Center For Biotechnology | Humanized antibodies against Globo H and uses thereof in cancer treatments |
| US12195554B2 (en) | 2018-03-14 | 2025-01-14 | Memorial Sloan Kettering Cancer Center | Anti-polysialic acid antibodies and uses thereof |
| AU2019276647A1 (en) * | 2018-06-01 | 2020-12-24 | Obi Pharma, Inc. | Combination therapy by using anti-Globo H or anti-SSEA-4 antibody with anti-negative immune check points antibody |
| TWI853822B (zh) | 2018-06-27 | 2024-09-01 | 台灣浩鼎生技股份有限公司 | 用於糖蛋白工程的糖苷合成酶變體及其使用方法 |
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| US20240066125A1 (en) * | 2021-02-09 | 2024-02-29 | Obi Pharma, Inc. | Globo series antigens-binding chimeric antigen receptors and uses thereof |
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| CN106456727B (zh) | 2014-04-10 | 2020-11-27 | 台湾浩鼎生技股份有限公司 | 抗体、产生所述抗体的杂交瘤、及其用途 |
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2015
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- 2015-04-10 KR KR1020167024072A patent/KR101966408B1/ko active Active
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- 2015-04-10 EP EP20151337.1A patent/EP3662928A1/en not_active Withdrawn
- 2015-04-10 SG SG11201607258SA patent/SG11201607258SA/en unknown
- 2015-04-10 JP JP2016554855A patent/JP2017512759A/ja active Pending
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- 2015-04-10 CN CN202011258954.4A patent/CN112390887B/zh active Active
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2016
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2017
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2018
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2020
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060165695A1 (en) * | 2002-04-30 | 2006-07-27 | Kenya Shitara | Antibody against human insulin-like growth factor |
| TW201100098A (en) * | 2009-06-16 | 2011-01-01 | Academia Sinica | Globo H and related anti-cancer vaccines with novel glycolipid adjuvants |
| US20120177664A1 (en) * | 2009-08-06 | 2012-07-12 | Immunas Pharma, Inc. | Antibodies That Specifically Bind to A Beta Oligomers and Use Thereof |
| US20130344089A1 (en) * | 2011-03-08 | 2013-12-26 | Alzinova Ab | Anti oligomer antibodies and uses thereof |
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