TWI561238B - Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient - Google Patents
Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredientInfo
- Publication number
- TWI561238B TWI561238B TW101135280A TW101135280A TWI561238B TW I561238 B TWI561238 B TW I561238B TW 101135280 A TW101135280 A TW 101135280A TW 101135280 A TW101135280 A TW 101135280A TW I561238 B TWI561238 B TW I561238B
- Authority
- TW
- Taiwan
- Prior art keywords
- inhibitor
- salts
- active ingredient
- cell death
- adenine dinucleotide
- Prior art date
Links
- 239000004480 active ingredient Substances 0.000 title 1
- 230000030833 cell death Effects 0.000 title 1
- 210000003560 epithelium corneal Anatomy 0.000 title 1
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 title 1
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 title 1
- 239000011714 flavin adenine dinucleotide Substances 0.000 title 1
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 title 1
- 239000003112 inhibitor Substances 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011210875 | 2011-09-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201318628A TW201318628A (zh) | 2013-05-16 |
| TWI561238B true TWI561238B (en) | 2016-12-11 |
Family
ID=47995597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101135280A TWI561238B (en) | 2011-09-27 | 2012-09-26 | Inhibitor of the corneal epithelium cell death comprising flavin adenine dinucleotide or salts thereof as the an active ingredient |
Country Status (9)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016046734A2 (en) * | 2014-09-22 | 2016-03-31 | University Of The Western Cape | Compounds and compositions for treatment of tuberculosis |
| EP4512395A1 (en) | 2023-08-21 | 2025-02-26 | Bio Even | Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014080015A2 (en) * | 2012-11-23 | 2014-05-30 | Pilosciences | Hair growth compositions and methods |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773076B1 (fr) * | 1997-12-29 | 2000-05-19 | Chauvin Lab Sa | Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec |
| JP4836401B2 (ja) * | 2002-04-01 | 2011-12-14 | ロート製薬株式会社 | 眼科用組成物 |
| JP2004203836A (ja) * | 2002-12-26 | 2004-07-22 | Rohto Pharmaceut Co Ltd | 眼科用局所適用製剤 |
| JP2005239622A (ja) * | 2004-02-26 | 2005-09-08 | Rohto Pharmaceut Co Ltd | 角膜障害治療剤 |
| JP4999304B2 (ja) * | 2004-09-27 | 2012-08-15 | ロート製薬株式会社 | ヒアルロン酸又はその塩を含有する粘膜適用組成物 |
| JP4969052B2 (ja) * | 2005-03-31 | 2012-07-04 | 小林製薬株式会社 | 眼科用組成物 |
| CN101301305A (zh) * | 2008-05-14 | 2008-11-12 | 北京润德康医药技术有限公司 | 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法 |
| JP5506357B2 (ja) * | 2009-12-02 | 2014-05-28 | ロート製薬株式会社 | シリコーンハイドロゲルコンタクトレンズ用眼科組成物 |
-
2012
- 2012-09-26 KR KR1020147009783A patent/KR20140082699A/ko not_active Withdrawn
- 2012-09-26 MY MYPI2014000895A patent/MY185239A/en unknown
- 2012-09-26 SG SG10201602401PA patent/SG10201602401PA/en unknown
- 2012-09-26 CN CN201280046826.0A patent/CN103826642B/zh not_active Expired - Fee Related
- 2012-09-26 TW TW101135280A patent/TWI561238B/zh not_active IP Right Cessation
- 2012-09-26 WO PCT/JP2012/074662 patent/WO2013047567A1/ja active Application Filing
- 2012-09-26 PH PH1/2014/500660A patent/PH12014500660A1/en unknown
- 2012-09-26 SG SG11201400947XA patent/SG11201400947XA/en unknown
- 2012-09-26 JP JP2012212575A patent/JP5969872B2/ja active Active
-
2014
- 2014-04-25 IN IN3350DEN2014 patent/IN2014DN03350A/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014080015A2 (en) * | 2012-11-23 | 2014-05-30 | Pilosciences | Hair growth compositions and methods |
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201400947XA (en) | 2014-07-30 |
| WO2013047567A1 (ja) | 2013-04-04 |
| MY185239A (en) | 2021-04-30 |
| KR20140082699A (ko) | 2014-07-02 |
| JP5969872B2 (ja) | 2016-08-17 |
| TW201318628A (zh) | 2013-05-16 |
| CN103826642A (zh) | 2014-05-28 |
| JP2013082696A (ja) | 2013-05-09 |
| SG10201602401PA (en) | 2016-04-28 |
| IN2014DN03350A (enrdf_load_stackoverflow) | 2015-06-05 |
| PH12014500660A1 (en) | 2014-05-05 |
| CN103826642B (zh) | 2016-02-17 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |