PH12014500660A1 - Corneal epithelial cell death inhibitor containing flavin adenine dinucleotide or salt thereof as active ingredient - Google Patents
Corneal epithelial cell death inhibitor containing flavin adenine dinucleotide or salt thereof as active ingredientInfo
- Publication number
- PH12014500660A1 PH12014500660A1 PH1/2014/500660A PH12014500660A PH12014500660A1 PH 12014500660 A1 PH12014500660 A1 PH 12014500660A1 PH 12014500660 A PH12014500660 A PH 12014500660A PH 12014500660 A1 PH12014500660 A1 PH 12014500660A1
- Authority
- PH
- Philippines
- Prior art keywords
- corneal epithelial
- salt
- cell death
- adenine dinucleotide
- epithelial cell
- Prior art date
Links
- 210000002919 epithelial cell Anatomy 0.000 title abstract 3
- 230000030833 cell death Effects 0.000 title abstract 2
- VWWQXMAJTJZDQX-UYBVJOGSSA-N flavin adenine dinucleotide Chemical compound C1=NC2=C(N)N=CN=C2N1[C@@H]([C@H](O)[C@@H]1O)O[C@@H]1CO[P@](O)(=O)O[P@@](O)(=O)OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C2=NC(=O)NC(=O)C2=NC2=C1C=C(C)C(C)=C2 VWWQXMAJTJZDQX-UYBVJOGSSA-N 0.000 title abstract 2
- 235000019162 flavin adenine dinucleotide Nutrition 0.000 title abstract 2
- 239000011714 flavin adenine dinucleotide Substances 0.000 title abstract 2
- 229940093632 flavin-adenine dinucleotide Drugs 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- 239000004480 active ingredient Substances 0.000 title 1
- 230000005855 radiation Effects 0.000 abstract 2
- 210000004027 cell Anatomy 0.000 abstract 1
- 230000007423 decrease Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7084—Compounds having two nucleosides or nucleotides, e.g. nicotinamide-adenine dinucleotide, flavine-adenine dinucleotide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011210875 | 2011-09-27 | ||
| PCT/JP2012/074662 WO2013047567A1 (ja) | 2011-09-27 | 2012-09-26 | フラビンアデニンジヌクレオチドまたはその塩を有効成分として含有する角膜上皮細胞死の抑制剤 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PH12014500660A1 true PH12014500660A1 (en) | 2014-05-05 |
Family
ID=47995597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PH1/2014/500660A PH12014500660A1 (en) | 2011-09-27 | 2012-09-26 | Corneal epithelial cell death inhibitor containing flavin adenine dinucleotide or salt thereof as active ingredient |
Country Status (9)
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016046734A2 (en) * | 2014-09-22 | 2016-03-31 | University Of The Western Cape | Compounds and compositions for treatment of tuberculosis |
| EP4512395A1 (en) | 2023-08-21 | 2025-02-26 | Bio Even | Composition comprising flavin adenine dinucleotide (fad), l-gsh, atp and myristic acid, alone or with a drug |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2773076B1 (fr) * | 1997-12-29 | 2000-05-19 | Chauvin Lab Sa | Utilisation de la flavine-adenine-dinucleotide pour la preparation de compositions ophtalmiques utiles pour le traitement de l'oeil sec |
| JP4836401B2 (ja) * | 2002-04-01 | 2011-12-14 | ロート製薬株式会社 | 眼科用組成物 |
| JP2004203836A (ja) * | 2002-12-26 | 2004-07-22 | Rohto Pharmaceut Co Ltd | 眼科用局所適用製剤 |
| JP2005239622A (ja) * | 2004-02-26 | 2005-09-08 | Rohto Pharmaceut Co Ltd | 角膜障害治療剤 |
| JP4999304B2 (ja) * | 2004-09-27 | 2012-08-15 | ロート製薬株式会社 | ヒアルロン酸又はその塩を含有する粘膜適用組成物 |
| JP4969052B2 (ja) * | 2005-03-31 | 2012-07-04 | 小林製薬株式会社 | 眼科用組成物 |
| CN101301305A (zh) * | 2008-05-14 | 2008-11-12 | 北京润德康医药技术有限公司 | 一种黄素腺嘌呤二核苷酸二钠冻干粉针制剂及其制备方法 |
| JP5506357B2 (ja) * | 2009-12-02 | 2014-05-28 | ロート製薬株式会社 | シリコーンハイドロゲルコンタクトレンズ用眼科組成物 |
| EP2735303A1 (en) * | 2012-11-23 | 2014-05-28 | Pilosciences | Hair growth compositions and methods |
-
2012
- 2012-09-26 KR KR1020147009783A patent/KR20140082699A/ko not_active Withdrawn
- 2012-09-26 MY MYPI2014000895A patent/MY185239A/en unknown
- 2012-09-26 SG SG10201602401PA patent/SG10201602401PA/en unknown
- 2012-09-26 CN CN201280046826.0A patent/CN103826642B/zh not_active Expired - Fee Related
- 2012-09-26 TW TW101135280A patent/TWI561238B/zh not_active IP Right Cessation
- 2012-09-26 WO PCT/JP2012/074662 patent/WO2013047567A1/ja active Application Filing
- 2012-09-26 PH PH1/2014/500660A patent/PH12014500660A1/en unknown
- 2012-09-26 SG SG11201400947XA patent/SG11201400947XA/en unknown
- 2012-09-26 JP JP2012212575A patent/JP5969872B2/ja active Active
-
2014
- 2014-04-25 IN IN3350DEN2014 patent/IN2014DN03350A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SG11201400947XA (en) | 2014-07-30 |
| WO2013047567A1 (ja) | 2013-04-04 |
| MY185239A (en) | 2021-04-30 |
| KR20140082699A (ko) | 2014-07-02 |
| JP5969872B2 (ja) | 2016-08-17 |
| TW201318628A (zh) | 2013-05-16 |
| CN103826642A (zh) | 2014-05-28 |
| JP2013082696A (ja) | 2013-05-09 |
| SG10201602401PA (en) | 2016-04-28 |
| IN2014DN03350A (enrdf_load_stackoverflow) | 2015-06-05 |
| TWI561238B (en) | 2016-12-11 |
| CN103826642B (zh) | 2016-02-17 |
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