TWI557224B - 具αｖβ３整合蛋白選擇性且與人類血清白蛋白（ＨＳＡ）變體結合之多肽及其於醫藥上之用途 - Google Patents
具αｖβ３整合蛋白選擇性且與人類血清白蛋白（ＨＳＡ）變體結合之多肽及其於醫藥上之用途 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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Landscapes
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| BR112012009450A2 (pt) | 2009-10-30 | 2017-05-23 | Novozymes Biopharma Dk As | variantes de albumina |
| US8357652B2 (en) * | 2009-11-20 | 2013-01-22 | Academia Sinica | Anti-tumor fibrillar human serum albumin methods and compositions |
| CN102883738A (zh) * | 2009-12-23 | 2013-01-16 | 成功大学 | 治疗血管发生相关的眼部疾病的组合物和方法 |
| CA2789337A1 (en) | 2010-02-16 | 2011-08-25 | Medimmune, Llc | Hsa-related compositions and methods of use |
| EP2556087A1 (en) | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
| AU2012251583B2 (en) | 2011-05-05 | 2017-06-08 | Albumedix Ltd. | Albumin variants |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| ES2664328T3 (es) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Variantes de albúmina |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| JP6886917B2 (ja) * | 2014-08-22 | 2021-06-16 | 國立成功大學Ｎａｔｉｏｎａｌ Ｃｈｅｎｇ Ｋｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | ロドストミンバリアント、ロドストミンバリアントをコードするポリヌクレオチド、当該ポリヌクレオチドを含む組換え宿主細胞、及びロドストミンバリアントを含む医薬組成物 |
| WO2017001990A1 (en) * | 2015-06-28 | 2017-01-05 | Allgenesis Biotherapeutics Inc. | Fusion proteins for inhibiting angiogenesis |
| CN117964732A (zh) | 2015-08-07 | 2024-05-03 | Alx肿瘤生物技术公司 | 具有SIRP-α结构域或其变体的构建体 |
| BR102016018074A2 (pt) * | 2015-08-07 | 2021-11-16 | ALX Oncology Inc. | Construção variante de sirp-alfa, seu método de preparação e seus usos, molécula de ácido nucleico, vetor, célula hospedeira, e composição farmacêutica |
| CA2989966C (en) | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| KR20210081389A (ko) | 2018-10-22 | 2021-07-01 | 얀센 파마슈티카 엔.브이. | 글루카곤 유사 펩티드 1(glp1)-성장 분화 인자 15(gdf15) 융합 단백질 및 이의 용도 |
| AU2020282791A1 (en) | 2019-05-31 | 2021-12-09 | ALX Oncology Inc. | Methods of treating cancer with SIRP alpha Fc fusion in combination with an immune checkpoint inhibitor |
| BR112022008817A2 (pt) | 2019-11-27 | 2022-07-26 | Alx Oncology Inc | Terapias combinadas para tratamento de câncer |
| WO2022196683A1 (ja) * | 2021-03-16 | 2022-09-22 | Ｋｍバイオロジクス株式会社 | 改変ヒト血清アルブミン－チオレドキシン融合体 |
| JP2024520902A (ja) | 2021-05-13 | 2024-05-27 | エーエルエックス オンコロジー インコーポレイテッド | がんを治療するための併用療法 |
| WO2026022392A1 (en) * | 2024-07-26 | 2026-01-29 | Ospedale San Raffaele S.R.L. | Peptide and conjugates thereof |
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| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| AU5939890A (en) * | 1989-06-07 | 1991-01-07 | Genentech Inc. | Platelet aggregation inhibitors and related molecules |
| US5525708A (en) * | 1994-03-28 | 1996-06-11 | Cytomed, Inc. | Covalent dimer of kit ligand |
| WO2003042354A2 (en) * | 2001-09-04 | 2003-05-22 | Aventis Pharmaceuticals Inc. | Abrogen polypeptides, nucleic acids encoding them and methods for using them to inhibit angiogenesis |
| CA2465891C (en) * | 2001-11-05 | 2012-05-15 | Board Of Regents, The University Of Texas System | Recombinant antibodies for the detection and neutralization of anthrax toxin |
| KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
| CA2489186C (en) * | 2002-06-07 | 2013-01-15 | Wisconsin Alumni Research Foundation | Chemical synthesis of reagents for peptide coupling |
| CA2560525A1 (en) * | 2004-03-18 | 2005-09-29 | The University Court Of The University Of Glasgow | Immunosuppressive cytokine |
| WO2008056961A1 (en) * | 2006-11-10 | 2008-05-15 | Boryung Pharmaceutical Co., Ltd | A novel fusion protein, cell lines expressing the same and preparation method thereof |
| US8183201B2 (en) * | 2006-12-26 | 2012-05-22 | National Cheng Kung University | Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin |
| CN102883738A (zh) * | 2009-12-23 | 2013-01-16 | 成功大学 | 治疗血管发生相关的眼部疾病的组合物和方法 |
-
2010
- 2010-07-19 KR KR1020127004303A patent/KR20120097481A/ko not_active Withdrawn
- 2010-07-19 AR ARP100102628A patent/AR077764A1/es unknown
- 2010-07-19 RU RU2012105915/10A patent/RU2547592C2/ru not_active IP Right Cessation
- 2010-07-19 AU AU2010276453A patent/AU2010276453A1/en not_active Abandoned
- 2010-07-19 WO PCT/US2010/042423 patent/WO2011011315A1/en not_active Ceased
- 2010-07-19 US US12/838,926 patent/US20110015130A1/en not_active Abandoned
- 2010-07-19 EP EP10802718A patent/EP2456454A4/en not_active Withdrawn
- 2010-07-19 JP JP2012521703A patent/JP2012533631A/ja active Pending
- 2010-07-19 MX MX2012000895A patent/MX2012000895A/es not_active Application Discontinuation
- 2010-07-19 CN CN2010800332967A patent/CN102470156A/zh active Pending
- 2010-07-19 NZ NZ597580A patent/NZ597580A/xx not_active IP Right Cessation
- 2010-07-19 TW TW099123673A patent/TWI557224B/zh active
- 2010-07-19 CA CA2768360A patent/CA2768360A1/en not_active Abandoned
-
2012
- 2012-01-08 IL IL217424A patent/IL217424A0/en unknown
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200848070A (en) * | 2006-12-26 | 2008-12-16 | Univ Nat Taiwan | Disintegrin variants and pharmaceutical uses thereof |
Non-Patent Citations (1)
| Title |
|---|
| Zhao et al, European Journal of Pharmaceutics and Biopharmaceutics,vol.72,no.2,p.405-411,2009. * |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2547592C2 (ru) | 2015-04-10 |
| JP2012533631A (ja) | 2012-12-27 |
| KR20120097481A (ko) | 2012-09-04 |
| IL217424A0 (en) | 2012-02-29 |
| AU2010276453A1 (en) | 2012-02-09 |
| EP2456454A4 (en) | 2013-03-20 |
| TW201107471A (en) | 2011-03-01 |
| CN102470156A (zh) | 2012-05-23 |
| NZ597580A (en) | 2013-11-29 |
| AR077764A1 (es) | 2011-09-21 |
| RU2012105915A (ru) | 2013-08-27 |
| EP2456454A1 (en) | 2012-05-30 |
| US20110015130A1 (en) | 2011-01-20 |
| CA2768360A1 (en) | 2011-01-27 |
| MX2012000895A (es) | 2012-06-01 |
| WO2011011315A1 (en) | 2011-01-27 |
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