JP2012533631A - ヒト血清アルブミン（ＨＳＡ）の変異体と接合したαｖβ３インテグリンに対して選択的なポリペプチドおよびその医薬上の使用 - Google Patents
ヒト血清アルブミン（ＨＳＡ）の変異体と接合したαｖβ３インテグリンに対して選択的なポリペプチドおよびその医薬上の使用 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017060462A (ja) * | 2015-08-07 | 2017-03-30 | アレキソ セラピューティクス インク． | Ｓｉｒｐ−アルファ変異体構築物及びその使用 |
| US11208459B2 (en) | 2015-08-07 | 2021-12-28 | ALX Oncology Inc. | Constructs having a SIRP-alpha domain or variant thereof |
| US11613564B2 (en) | 2019-05-31 | 2023-03-28 | ALX Oncology Inc. | Methods of treating cancer |
| US12098214B2 (en) | 2021-05-13 | 2024-09-24 | ALX Oncology Inc. | Combination therapies for treating cancer |
| US12527838B2 (en) | 2019-11-27 | 2026-01-20 | ALX Oncology Inc. | Combination therapies comprising an agent that blocks the interaction between CD47 and SIRPα for treating gastric or gastroesphageal junction cancel |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG172789A1 (en) | 2009-02-11 | 2011-08-29 | Novozymes Biopharma Dk As | Albumin variants and conjugates |
| BR112012009450A2 (pt) | 2009-10-30 | 2017-05-23 | Novozymes Biopharma Dk As | variantes de albumina |
| US8357652B2 (en) * | 2009-11-20 | 2013-01-22 | Academia Sinica | Anti-tumor fibrillar human serum albumin methods and compositions |
| CN102883738A (zh) * | 2009-12-23 | 2013-01-16 | 成功大学 | 治疗血管发生相关的眼部疾病的组合物和方法 |
| CA2789337A1 (en) | 2010-02-16 | 2011-08-25 | Medimmune, Llc | Hsa-related compositions and methods of use |
| EP2556087A1 (en) | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| US9045564B2 (en) | 2011-02-15 | 2015-06-02 | Medimmune, Llc | HSA-related compositions and methods of use |
| AU2012251583B2 (en) | 2011-05-05 | 2017-06-08 | Albumedix Ltd. | Albumin variants |
| EP2780364A2 (en) | 2011-11-18 | 2014-09-24 | Eleven Biotherapeutics, Inc. | Proteins with improved half-life and other properties |
| ES2664328T3 (es) | 2012-03-16 | 2018-04-19 | Albumedix A/S | Variantes de albúmina |
| CA2890766A1 (en) | 2012-11-08 | 2014-05-15 | Novozymes Biopharma Dk A/S | Albumin variants |
| JP6886917B2 (ja) * | 2014-08-22 | 2021-06-16 | 國立成功大學Ｎａｔｉｏｎａｌ Ｃｈｅｎｇ Ｋｕｎｇ Ｕｎｉｖｅｒｓｉｔｙ | ロドストミンバリアント、ロドストミンバリアントをコードするポリヌクレオチド、当該ポリヌクレオチドを含む組換え宿主細胞、及びロドストミンバリアントを含む医薬組成物 |
| WO2017001990A1 (en) * | 2015-06-28 | 2017-01-05 | Allgenesis Biotherapeutics Inc. | Fusion proteins for inhibiting angiogenesis |
| CA2989966C (en) | 2015-08-20 | 2024-04-30 | Albumedix A/S | Albumin variants and conjugates |
| US10336812B2 (en) * | 2016-05-10 | 2019-07-02 | Janssen Biotech, Inc. | GDF15 fusion proteins and uses thereof |
| KR20210081389A (ko) | 2018-10-22 | 2021-07-01 | 얀센 파마슈티카 엔.브이. | 글루카곤 유사 펩티드 1(glp1)-성장 분화 인자 15(gdf15) 융합 단백질 및 이의 용도 |
| WO2022196683A1 (ja) * | 2021-03-16 | 2022-09-22 | Ｋｍバイオロジクス株式会社 | 改変ヒト血清アルブミン－チオレドキシン融合体 |
| WO2026022392A1 (en) * | 2024-07-26 | 2026-01-29 | Ospedale San Raffaele S.R.L. | Peptide and conjugates thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH09512706A (ja) * | 1994-03-28 | 1997-12-22 | サイトメッド， インコーポレイテッド | ＫｉｔリガンドおよびＦＬＴ−３／ＦＬＫ−２リガンドの共有結合二量体 |
| WO2008088548A2 (en) * | 2006-12-26 | 2008-07-24 | National Taiwan University | Disintegrin variants and pharmaceutical uses thereof |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4179337A (en) * | 1973-07-20 | 1979-12-18 | Davis Frank F | Non-immunogenic polypeptides |
| JPS6023084B2 (ja) * | 1979-07-11 | 1985-06-05 | 味の素株式会社 | 代用血液 |
| US4640835A (en) * | 1981-10-30 | 1987-02-03 | Nippon Chemiphar Company, Ltd. | Plasminogen activator derivatives |
| US4496689A (en) * | 1983-12-27 | 1985-01-29 | Miles Laboratories, Inc. | Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer |
| EP0206448B1 (en) * | 1985-06-19 | 1990-11-14 | Ajinomoto Co., Inc. | Hemoglobin combined with a poly(alkylene oxide) |
| US4791192A (en) * | 1986-06-26 | 1988-12-13 | Takeda Chemical Industries, Ltd. | Chemically modified protein with polyethyleneglycol |
| AU5939890A (en) * | 1989-06-07 | 1991-01-07 | Genentech Inc. | Platelet aggregation inhibitors and related molecules |
| WO2003042354A2 (en) * | 2001-09-04 | 2003-05-22 | Aventis Pharmaceuticals Inc. | Abrogen polypeptides, nucleic acids encoding them and methods for using them to inhibit angiogenesis |
| CA2465891C (en) * | 2001-11-05 | 2012-05-15 | Board Of Regents, The University Of Texas System | Recombinant antibodies for the detection and neutralization of anthrax toxin |
| KR101271635B1 (ko) * | 2001-12-21 | 2013-06-12 | 휴먼 게놈 사이언시즈, 인코포레이티드 | 알부민 융합 단백질 |
| CA2489186C (en) * | 2002-06-07 | 2013-01-15 | Wisconsin Alumni Research Foundation | Chemical synthesis of reagents for peptide coupling |
| CA2560525A1 (en) * | 2004-03-18 | 2005-09-29 | The University Court Of The University Of Glasgow | Immunosuppressive cytokine |
| WO2008056961A1 (en) * | 2006-11-10 | 2008-05-15 | Boryung Pharmaceutical Co., Ltd | A novel fusion protein, cell lines expressing the same and preparation method thereof |
| US8183201B2 (en) * | 2006-12-26 | 2012-05-22 | National Cheng Kung University | Methods of treating αvβ3 integrin-associated diseases by administering polypeptides selective for αvβ3 integrin |
| CN102883738A (zh) * | 2009-12-23 | 2013-01-16 | 成功大学 | 治疗血管发生相关的眼部疾病的组合物和方法 |
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- 2010-07-19 MX MX2012000895A patent/MX2012000895A/es not_active Application Discontinuation
- 2010-07-19 CN CN2010800332967A patent/CN102470156A/zh active Pending
- 2010-07-19 NZ NZ597580A patent/NZ597580A/xx not_active IP Right Cessation
- 2010-07-19 TW TW099123673A patent/TWI557224B/zh active
- 2010-07-19 CA CA2768360A patent/CA2768360A1/en not_active Abandoned
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2012
- 2012-01-08 IL IL217424A patent/IL217424A0/en unknown
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| JPH09512706A (ja) * | 1994-03-28 | 1997-12-22 | サイトメッド， インコーポレイテッド | ＫｉｔリガンドおよびＦＬＴ−３／ＦＬＫ−２リガンドの共有結合二量体 |
| WO2008088548A2 (en) * | 2006-12-26 | 2008-07-24 | National Taiwan University | Disintegrin variants and pharmaceutical uses thereof |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017060462A (ja) * | 2015-08-07 | 2017-03-30 | アレキソ セラピューティクス インク． | Ｓｉｒｐ−アルファ変異体構築物及びその使用 |
| JP2021166521A (ja) * | 2015-08-07 | 2021-10-21 | エーエルエックス オンコロジー インコーポレイテッド | Ｓｉｒｐ−アルファ変異体構築物及びその使用 |
| US11208459B2 (en) | 2015-08-07 | 2021-12-28 | ALX Oncology Inc. | Constructs having a SIRP-alpha domain or variant thereof |
| US11639376B2 (en) | 2015-08-07 | 2023-05-02 | ALX Oncology Inc. | Constructs having a SIRP-α domain or variant thereof |
| US11613564B2 (en) | 2019-05-31 | 2023-03-28 | ALX Oncology Inc. | Methods of treating cancer |
| US12527838B2 (en) | 2019-11-27 | 2026-01-20 | ALX Oncology Inc. | Combination therapies comprising an agent that blocks the interaction between CD47 and SIRPα for treating gastric or gastroesphageal junction cancel |
| US12098214B2 (en) | 2021-05-13 | 2024-09-24 | ALX Oncology Inc. | Combination therapies for treating cancer |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2547592C2 (ru) | 2015-04-10 |
| KR20120097481A (ko) | 2012-09-04 |
| IL217424A0 (en) | 2012-02-29 |
| AU2010276453A1 (en) | 2012-02-09 |
| TWI557224B (zh) | 2016-11-11 |
| EP2456454A4 (en) | 2013-03-20 |
| TW201107471A (en) | 2011-03-01 |
| CN102470156A (zh) | 2012-05-23 |
| NZ597580A (en) | 2013-11-29 |
| AR077764A1 (es) | 2011-09-21 |
| RU2012105915A (ru) | 2013-08-27 |
| EP2456454A1 (en) | 2012-05-30 |
| US20110015130A1 (en) | 2011-01-20 |
| CA2768360A1 (en) | 2011-01-27 |
| MX2012000895A (es) | 2012-06-01 |
| WO2011011315A1 (en) | 2011-01-27 |
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