TWI555544B - 精準劑量控制機制及藥品傳送注射器及其製造方法 - Google Patents
精準劑量控制機制及藥品傳送注射器及其製造方法 Download PDFInfo
- Publication number
- TWI555544B TWI555544B TW101146033A TW101146033A TWI555544B TW I555544 B TWI555544 B TW I555544B TW 101146033 A TW101146033 A TW 101146033A TW 101146033 A TW101146033 A TW 101146033A TW I555544 B TWI555544 B TW I555544B
- Authority
- TW
- Taiwan
- Prior art keywords
- plunger
- syringe
- screw
- dose
- control mechanism
- Prior art date
Links
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31526—Dosing by means of stepwise axial movements, e.g. ratchet mechanisms or detents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568509P | 2011-12-08 | 2011-12-08 | |
| PCT/US2012/068210 WO2013086167A1 (en) | 2011-12-08 | 2012-12-06 | Accurate dose control mechanisms and drug delivery syringes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201330889A TW201330889A (zh) | 2013-08-01 |
| TWI555544B true TWI555544B (zh) | 2016-11-01 |
Family
ID=47472025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101146033A TWI555544B (zh) | 2011-12-08 | 2012-12-07 | 精準劑量控制機制及藥品傳送注射器及其製造方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9345839B2 (enExample) |
| EP (1) | EP2788054B1 (enExample) |
| JP (2) | JP6298946B2 (enExample) |
| KR (1) | KR20140105457A (enExample) |
| CN (1) | CN103998080B (enExample) |
| AU (1) | AU2012347818B2 (enExample) |
| BR (1) | BR112014013632A8 (enExample) |
| CA (1) | CA2857506C (enExample) |
| DK (1) | DK2788054T3 (enExample) |
| IL (1) | IL232733B (enExample) |
| IN (1) | IN2014CN04000A (enExample) |
| MX (1) | MX351572B (enExample) |
| PT (1) | PT2788054T (enExample) |
| RU (1) | RU2650207C2 (enExample) |
| TW (1) | TWI555544B (enExample) |
| WO (1) | WO2013086167A1 (enExample) |
| ZA (1) | ZA201404088B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| BR112013009205A2 (pt) | 2010-10-15 | 2016-07-26 | Iscience Interventional Corp | dispositivo para colocação na esclera de um olho, método para acessar o espaço supracoroidal de um olho, para acessar o espaço subretinal de um olho e para colocar um orifício dentro de um trato escleral em um olho. |
| EP2788054B1 (en) * | 2011-12-08 | 2018-04-25 | UNL Holdings LLC | Accurate dose control mechanisms and drug delivery syringes |
| WO2017204787A1 (en) * | 2011-12-08 | 2017-11-30 | Unitract Syringe Pty Ltd | Accurate dose control mechanisms and drug delivery syringes |
| CA3240136A1 (en) | 2012-11-08 | 2014-05-15 | Clearside Biomedical, Inc. | Methods and devices for the treatment of ocular diseases in human subjects |
| SG10201702674PA (en) | 2013-05-03 | 2017-06-29 | Clearside Biomedical Inc | Apparatus and methods for ocular injection |
| EP3003454B1 (en) | 2013-06-03 | 2020-01-08 | Clearside Biomedical, Inc. | Apparatus for drug delivery using multiple reservoirs |
| EP3431124A3 (en) * | 2013-07-16 | 2019-03-27 | UNL Holdings LLC | Syringes for sequential delivery of injectables |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| KR101472821B1 (ko) * | 2014-05-14 | 2014-12-16 | 김준우 | 성분 분리기 |
| RU2710491C2 (ru) | 2014-06-20 | 2019-12-26 | Клиасайд Байомедикал, Инк. | Устройство для инъекции лекарственного средства в глазную ткань и способ инъекции лекарственного средства в глазную ткань |
| US10049189B2 (en) * | 2014-09-29 | 2018-08-14 | Min Wei | Method for developing parenteral therapeutic product with drug delivery device through clinical trial |
| USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
| JP6471029B2 (ja) * | 2015-04-10 | 2019-02-13 | 株式会社ダイセル | 注射器 |
| EP4571272A3 (en) | 2015-07-12 | 2025-10-01 | Patients Pending Ltd. | Cover for a liquid delivery system with integrated plunger position sensing, and corresponding method |
| EP3187213A1 (en) * | 2015-12-29 | 2017-07-05 | Galderma S.A. | Syringe with click mechanism |
| EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
| TWI642455B (zh) * | 2016-02-25 | 2018-12-01 | 中央研究院 | 用於攪拌及遞送包含細胞之組成物的注射裝置 |
| US20190298490A1 (en) * | 2016-04-13 | 2019-10-03 | 3M Innovative Properties Company | A syringe for dispensing a dental substance |
| EP3442623B1 (en) | 2016-04-15 | 2021-01-20 | Santen Pharmaceutical Co., Ltd. | Accurate, precise microliter dosing syringe |
| JP2019514581A (ja) | 2016-05-02 | 2019-06-06 | クリアサイド バイオメディカル，インコーポレイテッド | 眼の薬物送達のためのシステムおよび方法 |
| EP3463517A1 (en) * | 2016-05-24 | 2019-04-10 | UNL Holdings LLC | Accurate dose control mechanisms and drug delivery syringes |
| CN109219457B (zh) * | 2016-06-17 | 2021-10-29 | 贝克顿·迪金森公司 | 用于润湿流体端口的内部流体路径表面以增进超声信号传输的方法和设备 |
| CN106038053B (zh) * | 2016-07-05 | 2018-11-20 | 颜繁诚 | 眼球后注药装置 |
| IL264764B2 (en) | 2016-08-12 | 2024-02-01 | Clearside Biomedical Inc | Devices and methods for adjusting the insertion depth of a drug administration needle |
| US11083851B2 (en) | 2016-09-17 | 2021-08-10 | Ethan Pedde | Methods, systems and devices for administering medication |
| WO2018204515A1 (en) | 2017-05-02 | 2018-11-08 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| EP3638346B1 (en) * | 2017-06-16 | 2025-10-15 | Credence Medsystems, Inc. | System and method for safety syringe |
| DE102017005779A1 (de) | 2017-06-19 | 2018-12-20 | Giesecke+Devrient Mobile Security Gmbh | Mikrooptisches Element mit Farbwechsel |
| FR3072297B1 (fr) * | 2017-10-17 | 2023-05-12 | Edix Sa | Dispositif d'injection manuelle |
| MX2020006177A (es) | 2017-12-13 | 2020-09-03 | Regeneron Pharma | Dispositivos y metodos para administracion exacta de dosis. |
| RU2710348C1 (ru) * | 2019-03-11 | 2019-12-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Универсальный одноразовый шприц |
| WO2020210498A1 (en) * | 2019-04-09 | 2020-10-15 | Congruence Medical Solutions, Llc | Injection device |
| IL267610A (en) * | 2019-06-24 | 2019-10-31 | Dali Medical Devices Ltd | dose monitoring |
| EP4058108A2 (en) * | 2019-11-14 | 2022-09-21 | Congruence Medical Solutions, LLC | Variable dosing syringe |
| JP2020121157A (ja) * | 2020-04-10 | 2020-08-13 | ユーエヌエル ホールディングス エルエルシーＵＮＬ Ｈｏｌｄｉｎｇｓ ＬＬＣ | 正確な投与量制御機構および薬物送達注射器 |
| CN111529826B (zh) * | 2020-05-28 | 2025-06-20 | 南京康友医疗科技有限公司 | 一种注射装置 |
| EP4168067B1 (en) | 2020-06-17 | 2025-08-27 | Credence Medsystems, Inc. | System and method for microdose injection |
| EP4190377A4 (en) * | 2020-08-20 | 2024-01-03 | TERUMO Kabushiki Kaisha | PRE-FILLED SYRINGE |
| US20220280389A1 (en) * | 2021-03-06 | 2022-09-08 | Control, Ltd. | Syringe Assembly & Method for Accurate Dosing |
| CN113578697B (zh) * | 2021-07-23 | 2023-07-28 | 信利光电股份有限公司 | 一种点导电银浆用注射器 |
| WO2024180081A1 (en) * | 2023-02-28 | 2024-09-06 | Dunne, Stephen Terence | Controlled dose syringe |
| WO2025154005A1 (en) * | 2024-01-19 | 2025-07-24 | Gupta Nalini K | An aseptic syringe for collection of samples |
| WO2025199106A1 (en) * | 2024-03-19 | 2025-09-25 | Halozyme, Inc. | Autoinjector |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3596659A (en) * | 1968-12-09 | 1971-08-03 | Nuclear Associates Inc | A shielding holder for a syringe |
| CN201168280Y (zh) * | 2008-03-28 | 2008-12-24 | 甘肃成纪生物药业有限公司 | 一种卡式瓶注射器 |
| US20090275914A1 (en) * | 2008-05-02 | 2009-11-05 | Sanofi-Aventis Deutschland Gmbh | Medication Delivery Device |
| US7867202B2 (en) * | 2005-05-24 | 2011-01-11 | Tecpharma Licensing Ag | Threaded rod and dose setting mechanism for an injection device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2943624A (en) | 1958-04-17 | 1960-07-05 | Mavis M Alquist | Quantitative indicator for syringes |
| US4018223A (en) | 1974-12-09 | 1977-04-19 | Andros Incorporated | Dosage control device |
| US4444335A (en) | 1981-09-14 | 1984-04-24 | Merck & Co., Inc. | Delivery of adjustable quantities of materials |
| US4465478A (en) | 1982-10-14 | 1984-08-14 | Collagen Corporation | Syringe force amplification device |
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2012
- 2012-12-06 EP EP12809422.4A patent/EP2788054B1/en not_active Not-in-force
- 2012-12-06 CN CN201280060269.8A patent/CN103998080B/zh not_active Expired - Fee Related
- 2012-12-06 CA CA2857506A patent/CA2857506C/en not_active Expired - Fee Related
- 2012-12-06 PT PT128094224T patent/PT2788054T/pt unknown
- 2012-12-06 MX MX2014006694A patent/MX351572B/es active IP Right Grant
- 2012-12-06 AU AU2012347818A patent/AU2012347818B2/en not_active Ceased
- 2012-12-06 WO PCT/US2012/068210 patent/WO2013086167A1/en not_active Ceased
- 2012-12-06 KR KR1020147015320A patent/KR20140105457A/ko not_active Abandoned
- 2012-12-06 IN IN4000CHN2014 patent/IN2014CN04000A/en unknown
- 2012-12-06 DK DK12809422.4T patent/DK2788054T3/en active
- 2012-12-06 BR BR112014013632A patent/BR112014013632A8/pt not_active Application Discontinuation
- 2012-12-06 US US13/707,201 patent/US9345839B2/en active Active
- 2012-12-06 JP JP2014546069A patent/JP6298946B2/ja not_active Expired - Fee Related
- 2012-12-06 RU RU2014126753A patent/RU2650207C2/ru not_active IP Right Cessation
- 2012-12-07 TW TW101146033A patent/TWI555544B/zh not_active IP Right Cessation
-
2014
- 2014-05-21 IL IL232733A patent/IL232733B/en active IP Right Grant
- 2014-06-05 ZA ZA2014/04088A patent/ZA201404088B/en unknown
-
2017
- 2017-08-23 JP JP2017160466A patent/JP6446714B2/ja not_active Expired - Fee Related
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112014013632A2 (pt) | 2017-06-13 |
| PT2788054T (pt) | 2018-07-30 |
| MX351572B (es) | 2017-10-18 |
| JP2015500095A (ja) | 2015-01-05 |
| CA2857506C (en) | 2020-01-14 |
| AU2012347818A1 (en) | 2014-06-12 |
| JP6298946B2 (ja) | 2018-03-28 |
| KR20140105457A (ko) | 2014-09-01 |
| IN2014CN04000A (enExample) | 2015-10-23 |
| AU2012347818B2 (en) | 2017-03-30 |
| RU2650207C2 (ru) | 2018-04-11 |
| US9345839B2 (en) | 2016-05-24 |
| HK1200125A1 (en) | 2015-07-31 |
| WO2013086167A1 (en) | 2013-06-13 |
| EP2788054A1 (en) | 2014-10-15 |
| US20130150803A1 (en) | 2013-06-13 |
| DK2788054T3 (en) | 2018-08-06 |
| CN103998080A (zh) | 2014-08-20 |
| IL232733A0 (en) | 2014-07-31 |
| JP6446714B2 (ja) | 2019-01-09 |
| EP2788054B1 (en) | 2018-04-25 |
| CN103998080B (zh) | 2017-03-08 |
| ZA201404088B (en) | 2016-08-31 |
| CA2857506A1 (en) | 2013-06-13 |
| JP2018061832A (ja) | 2018-04-19 |
| MX2014006694A (es) | 2014-07-14 |
| RU2014126753A (ru) | 2016-01-27 |
| TW201330889A (zh) | 2013-08-01 |
| BR112014013632A8 (pt) | 2017-06-13 |
| IL232733B (en) | 2019-01-31 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |