TWI555544B - 精準劑量控制機制及藥品傳送注射器及其製造方法 - Google Patents
精準劑量控制機制及藥品傳送注射器及其製造方法 Download PDFInfo
- Publication number
- TWI555544B TWI555544B TW101146033A TW101146033A TWI555544B TW I555544 B TWI555544 B TW I555544B TW 101146033 A TW101146033 A TW 101146033A TW 101146033 A TW101146033 A TW 101146033A TW I555544 B TWI555544 B TW I555544B
- Authority
- TW
- Taiwan
- Prior art keywords
- plunger
- syringe
- screw
- dose
- control mechanism
- Prior art date
Links
- 230000007246 mechanism Effects 0.000 title claims description 121
- 238000012377 drug delivery Methods 0.000 title claims description 37
- 238000000034 method Methods 0.000 title description 23
- 238000002347 injection Methods 0.000 claims description 37
- 239000007924 injection Substances 0.000 claims description 37
- 238000004519 manufacturing process Methods 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 14
- 229940071643 prefilled syringe Drugs 0.000 claims description 11
- 238000006073 displacement reaction Methods 0.000 claims description 7
- 239000000463 material Substances 0.000 claims description 5
- 230000036512 infertility Effects 0.000 claims description 4
- 239000000126 substance Substances 0.000 claims description 3
- 239000003814 drug Substances 0.000 description 95
- 229940079593 drug Drugs 0.000 description 73
- 238000012546 transfer Methods 0.000 description 33
- 230000006870 function Effects 0.000 description 10
- 230000000994 depressogenic effect Effects 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 239000000243 solution Substances 0.000 description 8
- 238000011282 treatment Methods 0.000 description 8
- 239000007788 liquid Substances 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 239000004033 plastic Substances 0.000 description 5
- 229920003023 plastic Polymers 0.000 description 5
- 210000003813 thumb Anatomy 0.000 description 5
- 229920000089 Cyclic olefin copolymer Polymers 0.000 description 4
- 230000009471 action Effects 0.000 description 4
- 239000000853 adhesive Substances 0.000 description 4
- 230000001070 adhesive effect Effects 0.000 description 4
- 239000004568 cement Substances 0.000 description 4
- 238000013461 design Methods 0.000 description 4
- 229920001971 elastomer Polymers 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- 238000006243 chemical reaction Methods 0.000 description 3
- 230000006835 compression Effects 0.000 description 3
- 238000007906 compression Methods 0.000 description 3
- 239000000806 elastomer Substances 0.000 description 3
- -1 for example Polymers 0.000 description 3
- 239000011521 glass Substances 0.000 description 3
- 239000003292 glue Substances 0.000 description 3
- 238000002483 medication Methods 0.000 description 3
- 238000003825 pressing Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 229920001169 thermoplastic Polymers 0.000 description 3
- 229920001187 thermosetting polymer Polymers 0.000 description 3
- 239000004713 Cyclic olefin copolymer Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 230000008878 coupling Effects 0.000 description 2
- 238000010168 coupling process Methods 0.000 description 2
- 238000005859 coupling reaction Methods 0.000 description 2
- 238000005429 filling process Methods 0.000 description 2
- 210000003811 finger Anatomy 0.000 description 2
- 230000010354 integration Effects 0.000 description 2
- 238000001990 intravenous administration Methods 0.000 description 2
- 230000000670 limiting effect Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 2
- 229920013730 reactive polymer Polymers 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 238000012549 training Methods 0.000 description 2
- 239000004925 Acrylic resin Substances 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 241000237858 Gastropoda Species 0.000 description 1
- 206010069803 Injury associated with device Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 230000004913 activation Effects 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000007767 bonding agent Substances 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000004590 computer program Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 230000006378 damage Effects 0.000 description 1
- 238000005034 decoration Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000002716 delivery method Methods 0.000 description 1
- 230000000881 depressing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 239000013013 elastic material Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000011065 in-situ storage Methods 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 239000003550 marker Substances 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 230000005012 migration Effects 0.000 description 1
- 238000013508 migration Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 230000036961 partial effect Effects 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 238000011002 quantification Methods 0.000 description 1
- 230000002829 reductive effect Effects 0.000 description 1
- 239000012744 reinforcing agent Substances 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 229910001220 stainless steel Inorganic materials 0.000 description 1
- 239000010935 stainless steel Substances 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 239000004634 thermosetting polymer Substances 0.000 description 1
- 239000004416 thermosoftening plastic Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31526—Dosing by means of stepwise axial movements, e.g. ratchet mechanisms or detents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31566—Means improving security or handling thereof
- A61M5/31573—Accuracy improving means
- A61M5/31575—Accuracy improving means using scaling up or down transmissions, e.g. gearbox
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/3129—Syringe barrels
- A61M5/3137—Specially designed finger grip means, e.g. for easy manipulation of the syringe rod
- A61M2005/3139—Finger grips not integrally formed with the syringe barrel, e.g. using adapter with finger grips
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
- A61M2005/3152—Piston or piston-rod constructions, e.g. connection of piston with piston-rod including gearings to multiply or attenuate the piston displacing force
-
- F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
- F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
- F04C—ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; ROTARY-PISTON, OR OSCILLATING-PISTON, POSITIVE-DISPLACEMENT PUMPS
- F04C2270/00—Control; Monitoring or safety arrangements
- F04C2270/04—Force
- F04C2270/041—Controlled or regulated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49826—Assembling or joining
Landscapes
- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161568509P | 2011-12-08 | 2011-12-08 | |
| PCT/US2012/068210 WO2013086167A1 (en) | 2011-12-08 | 2012-12-06 | Accurate dose control mechanisms and drug delivery syringes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW201330889A TW201330889A (zh) | 2013-08-01 |
| TWI555544B true TWI555544B (zh) | 2016-11-01 |
Family
ID=47472025
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW101146033A TWI555544B (zh) | 2011-12-08 | 2012-12-07 | 精準劑量控制機制及藥品傳送注射器及其製造方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9345839B2 (enExample) |
| EP (1) | EP2788054B1 (enExample) |
| JP (2) | JP6298946B2 (enExample) |
| KR (1) | KR20140105457A (enExample) |
| CN (1) | CN103998080B (enExample) |
| AU (1) | AU2012347818B2 (enExample) |
| BR (1) | BR112014013632A2 (enExample) |
| CA (1) | CA2857506C (enExample) |
| DK (1) | DK2788054T3 (enExample) |
| IL (1) | IL232733B (enExample) |
| IN (1) | IN2014CN04000A (enExample) |
| MX (1) | MX351572B (enExample) |
| PT (1) | PT2788054T (enExample) |
| RU (1) | RU2650207C2 (enExample) |
| TW (1) | TWI555544B (enExample) |
| WO (1) | WO2013086167A1 (enExample) |
| ZA (1) | ZA201404088B (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20070202186A1 (en) | 2006-02-22 | 2007-08-30 | Iscience Interventional Corporation | Apparatus and formulations for suprachoroidal drug delivery |
| US8197435B2 (en) | 2006-05-02 | 2012-06-12 | Emory University | Methods and devices for drug delivery to ocular tissue using microneedle |
| EP3520749A1 (en) | 2010-10-15 | 2019-08-07 | Clearside Biomedical, Inc. | Device for ocular access |
| US10213556B2 (en) | 2011-12-08 | 2019-02-26 | Unl Holdings Llc | Accurate dose control mechanisms and drug delivery syringes |
| BR112014013632A2 (pt) * | 2011-12-08 | 2017-06-13 | Unitract Syringe Pty Ltd | mecanismos de dose precisa e seringas de distribuição de fármaco |
| ES3023054T3 (en) | 2012-11-08 | 2025-05-29 | Clearside Biomedical Inc | Methods for the treatment of ocular disease in human subjects |
| KR102282973B1 (ko) | 2013-05-03 | 2021-07-27 | 클리어사이드 바이오메디컬, 인코포레이드 | 안구용 주사를 위한 장치 및 방법 |
| US10188550B2 (en) | 2013-06-03 | 2019-01-29 | Clearside Biomedical, Inc. | Apparatus and methods for drug delivery using multiple reservoirs |
| JP6574767B2 (ja) * | 2013-07-16 | 2019-09-11 | ユーエヌエル ホールディングス リミテッド ライアビリティ カンパニー | 注射物の順次送り出しのための注射器 |
| US20150158926A1 (en) | 2013-10-21 | 2015-06-11 | Opko Biologics, Ltd. | Long-acting polypeptides and methods of producing and administering same |
| KR101472821B1 (ko) * | 2014-05-14 | 2014-12-16 | 김준우 | 성분 분리기 |
| EP3157598A4 (en) | 2014-06-20 | 2018-05-16 | Clearside Biomedical, Inc. | Variable diameter cannula and methods for controlling insertion depth for medicament delivery |
| US10049189B2 (en) * | 2014-09-29 | 2018-08-14 | Min Wei | Method for developing parenteral therapeutic product with drug delivery device through clinical trial |
| USD750223S1 (en) | 2014-10-14 | 2016-02-23 | Clearside Biomedical, Inc. | Medical injector for ocular injection |
| JP6471029B2 (ja) * | 2015-04-10 | 2019-02-13 | 株式会社ダイセル | 注射器 |
| AU2016291849B2 (en) | 2015-07-12 | 2021-09-23 | Patients Pending Ltd. | Cover for liquid delivery system with integrated plunger position sensing, and corresponding method |
| EP3187213A1 (en) * | 2015-12-29 | 2017-07-05 | Galderma S.A. | Syringe with click mechanism |
| EP3413851B1 (en) | 2016-02-10 | 2023-09-27 | Clearside Biomedical, Inc. | Packaging |
| TWI642455B (zh) | 2016-02-25 | 2018-12-01 | 中央研究院 | 用於攪拌及遞送包含細胞之組成物的注射裝置 |
| WO2017180545A1 (en) * | 2016-04-13 | 2017-10-19 | 3M Innovative Properties Company | A syringe for dispensing a dental substance |
| JP7076106B2 (ja) | 2016-04-15 | 2022-05-27 | 参天製薬株式会社 | 正確で優れた精度のマイクロリットル投薬シリンジ |
| EP3452165A1 (en) | 2016-05-02 | 2019-03-13 | Clearside Biomedical, Inc. | Systems and methods for ocular drug delivery |
| AU2016408375A1 (en) * | 2016-05-24 | 2019-01-03 | Unl Holdings Llc | Accurate dose control mechanisms and drug delivery syringes |
| JP7021119B2 (ja) * | 2016-06-17 | 2022-02-16 | ベクトン・ディキンソン・アンド・カンパニー | 流体ポートの内部流路表面を濡らして超音波信号送信を向上させるための方法及び装置 |
| CN106038053B (zh) * | 2016-07-05 | 2018-11-20 | 颜繁诚 | 眼球后注药装置 |
| US10973681B2 (en) | 2016-08-12 | 2021-04-13 | Clearside Biomedical, Inc. | Devices and methods for adjusting the insertion depth of a needle for medicament delivery |
| US11083851B2 (en) | 2016-09-17 | 2021-08-10 | Ethan Pedde | Methods, systems and devices for administering medication |
| US12090294B2 (en) | 2017-05-02 | 2024-09-17 | Georgia Tech Research Corporation | Targeted drug delivery methods using a microneedle |
| EP3638346B1 (en) * | 2017-06-16 | 2025-10-15 | Credence Medsystems, Inc. | System and method for safety syringe |
| DE102017005779A1 (de) | 2017-06-19 | 2018-12-20 | Giesecke+Devrient Mobile Security Gmbh | Mikrooptisches Element mit Farbwechsel |
| FR3072297B1 (fr) * | 2017-10-17 | 2023-05-12 | Edix Sa | Dispositif d'injection manuelle |
| CN117065152A (zh) | 2017-12-13 | 2023-11-17 | 里珍纳龙药品有限公司 | 用于精确剂量输送的装置和方法 |
| RU2710348C1 (ru) * | 2019-03-11 | 2019-12-25 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Ярославский государственный медицинский университет" Министерства здравоохранения Российской Федерации | Универсальный одноразовый шприц |
| MX2021012304A (es) * | 2019-04-09 | 2021-12-15 | Congruence Medical Solutions Llc | Dispositivo de inyeccion. |
| IL267610A (en) * | 2019-06-24 | 2019-10-31 | Dali Medical Devices Ltd | dose monitoring |
| CN120022470A (zh) * | 2019-11-14 | 2025-05-23 | 和谐医疗解决方案有限责任公司 | 可变剂量注射筒 |
| JP2020121157A (ja) * | 2020-04-10 | 2020-08-13 | ユーエヌエル ホールディングス エルエルシーＵＮＬ Ｈｏｌｄｉｎｇｓ ＬＬＣ | 正確な投与量制御機構および薬物送達注射器 |
| CN111529826B (zh) * | 2020-05-28 | 2025-06-20 | 南京康友医疗科技有限公司 | 一种注射装置 |
| EP4168067B1 (en) | 2020-06-17 | 2025-08-27 | Credence Medsystems, Inc. | System and method for microdose injection |
| JP7783819B2 (ja) * | 2020-08-20 | 2025-12-10 | テルモ株式会社 | プレフィルドシリンジ |
| US20220280389A1 (en) * | 2021-03-06 | 2022-09-08 | Control, Ltd. | Syringe Assembly & Method for Accurate Dosing |
| CN113578697B (zh) * | 2021-07-23 | 2023-07-28 | 信利光电股份有限公司 | 一种点导电银浆用注射器 |
| WO2024180081A1 (en) * | 2023-02-28 | 2024-09-06 | Dunne, Stephen Terence | Controlled dose syringe |
| WO2025154005A1 (en) * | 2024-01-19 | 2025-07-24 | Gupta Nalini K | An aseptic syringe for collection of samples |
| WO2025199106A1 (en) * | 2024-03-19 | 2025-09-25 | Halozyme, Inc. | Autoinjector |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3596659A (en) * | 1968-12-09 | 1971-08-03 | Nuclear Associates Inc | A shielding holder for a syringe |
| CN201168280Y (zh) * | 2008-03-28 | 2008-12-24 | 甘肃成纪生物药业有限公司 | 一种卡式瓶注射器 |
| US20090275914A1 (en) * | 2008-05-02 | 2009-11-05 | Sanofi-Aventis Deutschland Gmbh | Medication Delivery Device |
| US7867202B2 (en) * | 2005-05-24 | 2011-01-11 | Tecpharma Licensing Ag | Threaded rod and dose setting mechanism for an injection device |
Family Cites Families (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2943624A (en) | 1958-04-17 | 1960-07-05 | Mavis M Alquist | Quantitative indicator for syringes |
| US4018223A (en) | 1974-12-09 | 1977-04-19 | Andros Incorporated | Dosage control device |
| US4444335A (en) | 1981-09-14 | 1984-04-24 | Merck & Co., Inc. | Delivery of adjustable quantities of materials |
| US4465478A (en) | 1982-10-14 | 1984-08-14 | Collagen Corporation | Syringe force amplification device |
| GB2140302A (en) | 1983-05-26 | 1984-11-28 | Microsurgical Equipment Ltd | An aspiration adaptor for a syringe |
| FR2583291A1 (fr) | 1985-06-14 | 1986-12-19 | Hazon Bernard | Dispositif d'avancement pas a pas du piston de seringues par double vis coaxiale avec controle du debit d'injection. application aux injections medicamenteuses intra-dermiques repetitives |
| US4687472A (en) | 1986-11-12 | 1987-08-18 | Gross Daniel A | Injection assisting apparatus |
| GB8713810D0 (en) | 1987-06-12 | 1987-07-15 | Hypoguard Uk Ltd | Measured dose dispensing device |
| EP0341281B1 (en) * | 1987-11-06 | 1993-03-24 | ELLGASS, Louis Paul | Non-reusable syringe |
| US5135511A (en) | 1990-08-22 | 1992-08-04 | Becton, Dickinson And Company | Assembly for aspirating tissue, including adapter for syringe |
| US5115816A (en) | 1991-01-24 | 1992-05-26 | Peter F. Lee, Inc. | Single-hand controlled fine needle aspiration device |
| AR243387A1 (es) | 1991-10-03 | 1993-08-31 | Cesar Gabriel Corsich | Jeringa hipodermica con embolo trabable para evitar su recarga y reutilizacion. |
| US5378233A (en) | 1992-11-18 | 1995-01-03 | Habley Medical Technology Corporation | Selected dose pharmaceutical dispenser |
| US5346475A (en) | 1993-10-27 | 1994-09-13 | Edward Gregorio | Single use syringe |
| US5531691A (en) | 1994-02-14 | 1996-07-02 | Univec Inc. | Single use syringe assembly |
| US5562623A (en) | 1994-02-14 | 1996-10-08 | Univec | Single-use syringe assembly including spring clip lock and plunger |
| US5674204A (en) * | 1995-09-19 | 1997-10-07 | Becton Dickinson And Company | Medication delivery pen cap actuated dose delivery clutch |
| US5582595A (en) | 1995-09-28 | 1996-12-10 | Habley Medical Technology Corporation | Aspirating syringe having a plunger guide for a reciprocating plunger assembly |
| US5819983A (en) | 1995-11-22 | 1998-10-13 | Camelot Sysems, Inc. | Liquid dispensing system with sealing augering screw and method for dispensing |
| JPH09225031A (ja) * | 1996-02-28 | 1997-09-02 | Terumo Corp | 定量分与器 |
| US6533758B1 (en) * | 1997-07-18 | 2003-03-18 | Liebel-Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
| US6004297A (en) * | 1998-01-30 | 1999-12-21 | Novo Nordisk A/S | Injection syringe |
| US6221053B1 (en) * | 1998-02-20 | 2001-04-24 | Becton, Dickinson And Company | Multi-featured medication delivery pen |
| JP3832148B2 (ja) | 1999-02-08 | 2006-10-11 | フジノン株式会社 | シリンジ用アダプタ装置 |
| WO2001019428A2 (en) | 1999-09-13 | 2001-03-22 | Vitro Diagnostics, Inc. | Multi-dose syringe driver |
| US6231550B1 (en) | 1999-12-02 | 2001-05-15 | Joshua D. Laughlin | One-handed single grip position aspiration and injection syringe |
| US6533756B2 (en) | 2000-02-10 | 2003-03-18 | Univec, Inc. | Single use syringe |
| US7500959B2 (en) | 2000-10-05 | 2009-03-10 | Novo Nordisk A/S | Medication delivery system with improved dose accuracy |
| DE10235468A1 (de) | 2001-08-08 | 2003-04-30 | Ntn Toyo Bearing Co Ltd | Spritzenpumpe |
| EP1446328B1 (en) | 2001-10-16 | 2017-05-31 | Medical Instill Technologies, Inc. | DISPENSER WITH SEALED CHAMBER AND ONE−WAY VALVE FOR PROVIDING METERED AMOUNTS OF SUBSTANCES |
| US7798185B2 (en) | 2005-08-01 | 2010-09-21 | Medical Instill Technologies, Inc. | Dispenser and method for storing and dispensing sterile food product |
| AUPS053902A0 (en) | 2002-02-14 | 2002-03-07 | Hawthorne, Matthew | Aspiration device |
| US6719735B1 (en) | 2003-02-28 | 2004-04-13 | Gammon Technical Products, Inc. | Syringe adapter |
| US7967772B2 (en) | 2004-01-12 | 2011-06-28 | Iscience Interventional Corporation | Injector for viscous materials |
| JP4668982B2 (ja) | 2004-03-30 | 2011-04-13 | イーライ リリー アンド カンパニー | 開口部のある駆動部分を持つギアセット付き薬剤投与器具 |
| WO2006058883A2 (en) * | 2004-12-01 | 2006-06-08 | Novo Nordisk A/S | Injection device |
| EP1868669B1 (en) | 2005-04-15 | 2016-10-19 | Unitract Syringe Pty Ltd | Controlled retraction syringe and plunger therefor |
| EP1879635A4 (en) | 2005-05-12 | 2016-08-24 | Unitract Syringe Pty Ltd | ENHANCED ADJUSTABLE TRAPPER SYRINGE AND ITS PLUNGER |
| US7611495B1 (en) | 2005-10-07 | 2009-11-03 | Gianturco Michael C | Device for manually controlling delivery rate of a hypodermic syringe and syringe having same |
| WO2007094833A1 (en) | 2006-02-14 | 2007-08-23 | Battelle Memorial Institute | Accurate metering system |
| US8057427B2 (en) | 2007-05-09 | 2011-11-15 | Meridian Medical Technologies, Inc. | Drug delivery system with a small amount of a therapeutic agent |
| CN101715371B (zh) | 2007-05-14 | 2012-09-05 | Shl集团有限责任公司 | 输送装置 |
| NZ595031A (en) | 2007-07-02 | 2012-02-24 | Unitract Syringe Pty Ltd | Automatically retracting syringe with spring based mechanisim |
| ES2377047T3 (es) * | 2008-05-02 | 2012-03-22 | Sanofi-Aventis Deutschland Gmbh | Dispositivo de suministro de medicación |
| CA2745077A1 (en) * | 2008-12-04 | 2010-06-10 | Sanofi-Aventis Deutschland Gmbh | Injection device with holding means to prevent unintentional movements of piston rod |
| ES2909887T3 (es) * | 2009-12-01 | 2022-05-10 | Becton Dickinson Co | Pluma de inyección con retroceso automático y control de última dosis |
| MX2012007116A (es) | 2009-12-22 | 2012-12-17 | Unitract Syringe Pty Ltd | Jeringa retractil con eficiencia de suministro mejorada y sistema de bloqueo. |
| MX341512B (es) | 2010-05-04 | 2016-08-23 | Unitract Syringe Pty Ltd * | Adaptador de cilindro de jeringa y ensamble de aguja. |
| BR112014013632A2 (pt) * | 2011-12-08 | 2017-06-13 | Unitract Syringe Pty Ltd | mecanismos de dose precisa e seringas de distribuição de fármaco |
-
2012
- 2012-12-06 BR BR112014013632A patent/BR112014013632A2/pt not_active Application Discontinuation
- 2012-12-06 PT PT128094224T patent/PT2788054T/pt unknown
- 2012-12-06 CA CA2857506A patent/CA2857506C/en not_active Expired - Fee Related
- 2012-12-06 MX MX2014006694A patent/MX351572B/es active IP Right Grant
- 2012-12-06 DK DK12809422.4T patent/DK2788054T3/en active
- 2012-12-06 WO PCT/US2012/068210 patent/WO2013086167A1/en not_active Ceased
- 2012-12-06 JP JP2014546069A patent/JP6298946B2/ja not_active Expired - Fee Related
- 2012-12-06 RU RU2014126753A patent/RU2650207C2/ru not_active IP Right Cessation
- 2012-12-06 CN CN201280060269.8A patent/CN103998080B/zh not_active Expired - Fee Related
- 2012-12-06 AU AU2012347818A patent/AU2012347818B2/en not_active Ceased
- 2012-12-06 US US13/707,201 patent/US9345839B2/en active Active
- 2012-12-06 KR KR1020147015320A patent/KR20140105457A/ko not_active Abandoned
- 2012-12-06 IN IN4000CHN2014 patent/IN2014CN04000A/en unknown
- 2012-12-06 EP EP12809422.4A patent/EP2788054B1/en not_active Not-in-force
- 2012-12-07 TW TW101146033A patent/TWI555544B/zh not_active IP Right Cessation
-
2014
- 2014-05-21 IL IL232733A patent/IL232733B/en active IP Right Grant
- 2014-06-05 ZA ZA2014/04088A patent/ZA201404088B/en unknown
-
2017
- 2017-08-23 JP JP2017160466A patent/JP6446714B2/ja not_active Expired - Fee Related
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3596659A (en) * | 1968-12-09 | 1971-08-03 | Nuclear Associates Inc | A shielding holder for a syringe |
| US7867202B2 (en) * | 2005-05-24 | 2011-01-11 | Tecpharma Licensing Ag | Threaded rod and dose setting mechanism for an injection device |
| CN201168280Y (zh) * | 2008-03-28 | 2008-12-24 | 甘肃成纪生物药业有限公司 | 一种卡式瓶注射器 |
| US20090275914A1 (en) * | 2008-05-02 | 2009-11-05 | Sanofi-Aventis Deutschland Gmbh | Medication Delivery Device |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130150803A1 (en) | 2013-06-13 |
| WO2013086167A1 (en) | 2013-06-13 |
| JP2018061832A (ja) | 2018-04-19 |
| CN103998080B (zh) | 2017-03-08 |
| EP2788054A1 (en) | 2014-10-15 |
| DK2788054T3 (en) | 2018-08-06 |
| TW201330889A (zh) | 2013-08-01 |
| IN2014CN04000A (enExample) | 2015-10-23 |
| AU2012347818A1 (en) | 2014-06-12 |
| EP2788054B1 (en) | 2018-04-25 |
| AU2012347818B2 (en) | 2017-03-30 |
| ZA201404088B (en) | 2016-08-31 |
| JP2015500095A (ja) | 2015-01-05 |
| MX351572B (es) | 2017-10-18 |
| RU2014126753A (ru) | 2016-01-27 |
| IL232733B (en) | 2019-01-31 |
| PT2788054T (pt) | 2018-07-30 |
| CA2857506A1 (en) | 2013-06-13 |
| HK1200125A1 (en) | 2015-07-31 |
| JP6446714B2 (ja) | 2019-01-09 |
| IL232733A0 (en) | 2014-07-31 |
| MX2014006694A (es) | 2014-07-14 |
| KR20140105457A (ko) | 2014-09-01 |
| BR112014013632A8 (pt) | 2017-06-13 |
| BR112014013632A2 (pt) | 2017-06-13 |
| JP6298946B2 (ja) | 2018-03-28 |
| CN103998080A (zh) | 2014-08-20 |
| RU2650207C2 (ru) | 2018-04-11 |
| CA2857506C (en) | 2020-01-14 |
| US9345839B2 (en) | 2016-05-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI555544B (zh) | 精準劑量控制機制及藥品傳送注射器及其製造方法 | |
| JP7568670B2 (ja) | 注射ペン | |
| US10213556B2 (en) | Accurate dose control mechanisms and drug delivery syringes | |
| US10328211B2 (en) | Automatic self-dispensing accurate dose drug delivery syringes | |
| AU2014328035B2 (en) | Automatic self-dispensing accurate dose drug delivery syringes | |
| KR20190013854A (ko) | 정확 투여 제어 메커니즘 및 약물 전달 주사기 | |
| US10603444B2 (en) | Automatic injection device with variable dosing | |
| US20240374824A1 (en) | Medical delivery device | |
| JP2020121157A (ja) | 正確な投与量制御機構および薬物送達注射器 | |
| HK1200125B (en) | Accurate dose control mechanisms and drug delivery syringes |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |