TWI481870B - 用於軟組織疾病診斷及作為用於口腔保健干預的標靶之蛋白質生物標記 - Google Patents

用於軟組織疾病診斷及作為用於口腔保健干預的標靶之蛋白質生物標記 Download PDF

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Publication number
TWI481870B
TWI481870B TW099109774A TW99109774A TWI481870B TW I481870 B TWI481870 B TW I481870B TW 099109774 A TW099109774 A TW 099109774A TW 99109774 A TW99109774 A TW 99109774A TW I481870 B TWI481870 B TW I481870B
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Taiwan
Prior art keywords
biomarker
mmp
sample
periodontal disease
biomarkers
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TW099109774A
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English (en)
Chinese (zh)
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TW201102653A (en
Inventor
Ying Yang
Harsh M Trivedi
Tao Xu
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Colgate Palmolive Co
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Publication of TW201102653A publication Critical patent/TW201102653A/zh
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Publication of TWI481870B publication Critical patent/TWI481870B/zh

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56955—Bacteria involved in periodontal diseases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/60—Complex ways of combining multiple protein biomarkers for diagnosis

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Biotechnology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW099109774A 2009-04-01 2010-03-31 用於軟組織疾病診斷及作為用於口腔保健干預的標靶之蛋白質生物標記 TWI481870B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US16567409P 2009-04-01 2009-04-01

Publications (2)

Publication Number Publication Date
TW201102653A TW201102653A (en) 2011-01-16
TWI481870B true TWI481870B (zh) 2015-04-21

Family

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Family Applications (1)

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TW099109774A TWI481870B (zh) 2009-04-01 2010-03-31 用於軟組織疾病診斷及作為用於口腔保健干預的標靶之蛋白質生物標記

Country Status (15)

Country Link
US (1) US8753820B2 (pt)
EP (1) EP2414837B1 (pt)
JP (1) JP5643288B2 (pt)
CN (1) CN102549432B (pt)
AR (1) AR076041A1 (pt)
BR (1) BRPI1013184A2 (pt)
CA (1) CA2753718C (pt)
CO (1) CO6430490A2 (pt)
MX (1) MX2011008439A (pt)
MY (1) MY179250A (pt)
RU (1) RU2523383C2 (pt)
SG (1) SG173461A1 (pt)
TW (1) TWI481870B (pt)
WO (1) WO2010115034A2 (pt)
ZA (1) ZA201106056B (pt)

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AR076177A1 (es) * 2009-04-01 2011-05-26 Colgate Palmolive Co MÉTODO PARA IDENTIFICAR UN COMPUESTO uTIL PARA TRATAR UNA ENFERMEDAD O CONDICIoN DE LA CAVIDAD ORAL
US9949671B2 (en) 2013-03-13 2018-04-24 Orthoaccel Technologies, Inc. Diagnostic mouthpieces
US20190339269A1 (en) * 2017-01-03 2019-11-07 The Trustees Of The University Of Pennsylvania Compositions and methods for predicting risk of preterm birth
WO2018215630A1 (en) * 2017-05-24 2018-11-29 Koninklijke Philips N.V. Diagnostics of periodontitis based on salivary hgf and mmp-8
CN110678755A (zh) 2017-05-24 2020-01-10 皇家飞利浦有限公司 基于唾液白介素-1β以及MMP-9的轻度或重度牙周炎的诊断
RU2019143602A (ru) * 2017-05-24 2021-06-24 Конинклейке Филипс Н.В. Диагностика гингивита на основании ил-1бета и фактора роста гепатоцитов в слюне
US11124833B2 (en) 2017-10-27 2021-09-21 Colgate-Palmolive Company Salivary extracellular RNA biomarkers for gingivitis
EP3477306A1 (en) * 2017-10-30 2019-05-01 Koninklijke Philips N.V. Classification of periodontitis patients

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Also Published As

Publication number Publication date
AR076041A1 (es) 2011-05-11
MX2011008439A (es) 2011-09-06
CA2753718C (en) 2015-06-23
EP2414837A2 (en) 2012-02-08
ZA201106056B (en) 2015-05-27
JP5643288B2 (ja) 2014-12-17
JP2012522994A (ja) 2012-09-27
SG173461A1 (en) 2011-09-29
RU2011144032A (ru) 2013-05-10
US20120028261A1 (en) 2012-02-02
CN102549432B (zh) 2015-03-25
RU2523383C2 (ru) 2014-07-20
BRPI1013184A2 (pt) 2016-04-12
AU2010232593A1 (en) 2011-08-25
CN102549432A (zh) 2012-07-04
CA2753718A1 (en) 2010-10-07
WO2010115034A3 (en) 2010-12-29
EP2414837B1 (en) 2015-06-03
TW201102653A (en) 2011-01-16
US8753820B2 (en) 2014-06-17
WO2010115034A2 (en) 2010-10-07
CO6430490A2 (es) 2012-04-30
MY179250A (en) 2020-11-02

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