TWI459944B - 含有硫辛酸衍生物之醫藥調配物 - Google Patents
含有硫辛酸衍生物之醫藥調配物 Download PDFInfo
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- TWI459944B TWI459944B TW097114308A TW97114308A TWI459944B TW I459944 B TWI459944 B TW I459944B TW 097114308 A TW097114308 A TW 097114308A TW 97114308 A TW97114308 A TW 97114308A TW I459944 B TWI459944 B TW I459944B
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- Prior art keywords
- lipoic acid
- pharmaceutical formulation
- group
- cancer
- acid derivative
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Classifications
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/205—Amine addition salts of organic acids; Inner quaternary ammonium salts, e.g. betaine, carnitine
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
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- A—HUMAN NECESSITIES
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/541—Organic ions forming an ion pair complex with the pharmacologically or therapeutically active agent
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Life Sciences & Earth Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Hematology (AREA)
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- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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| MX2009011165A (es) | 2007-04-18 | 2009-12-09 | Cornerstone Pharmaceuticals In | Formulaciones farmaceuticas que contienen derivados del acido lipoico. |
| EP2139321B1 (en) * | 2007-04-18 | 2013-11-06 | Cornerstone Pharmaceuticals, Inc. | Lipoic acid derivatives |
| US8263653B2 (en) * | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
| MX2010009673A (es) * | 2008-03-04 | 2011-03-15 | Robert Shorr | Modulacion de la estructura, actividad y/o nivel de expresion enzimaticos. |
| WO2009123597A1 (en) * | 2008-04-04 | 2009-10-08 | Robert Shorr | Pharmaceutical composition |
| EP2389178A4 (en) * | 2008-12-01 | 2012-06-06 | Invasc Therapeutic Inc | COMPOSITIONS CONTAINING INHIBITORS OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND LIPOIC ACID COMPOUNDS, AND THEIR USE FOR THE TREATMENT OF RENIN-ANGIOTENSIN-ALDOSTERONE ASSOCIATED DISORDERS |
| WO2010110771A2 (en) * | 2009-03-25 | 2010-09-30 | Frank Gibson | Substituted thiol-containing alkyl fatty acids and process for synthesizing derivatives thereof |
| SI3338765T1 (sl) | 2009-12-01 | 2019-05-31 | Translate Bio, Inc. | Derivat steroida za dostavo MRNA pri humanih genetskih boleznih |
| WO2011143593A1 (en) * | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Conjugates of a lipoic acid derivative and anti-proliferation agent and medical uses thereof |
| WO2011143590A1 (en) * | 2010-05-14 | 2011-11-17 | Cornerstone Pharmaceuticals, Inc. | Combination therapy compositions and methods using lipoic acid derivatives and an anti-proliferation agent |
| WO2012170930A1 (en) | 2011-06-08 | 2012-12-13 | Shire Human Genetic Therapies, Inc | Lipid nanoparticle compositions and methods for mrna delivery |
| CN102657606B (zh) * | 2012-05-25 | 2014-01-01 | 江苏神龙药业有限公司 | 一种供静脉给药用的硫辛酸注射液 |
| WO2013185067A1 (en) | 2012-06-08 | 2013-12-12 | Shire Human Genetic Therapies, Inc. | Nuclease resistant polynucleotides and uses thereof |
| EP2934542A4 (en) * | 2012-12-19 | 2016-08-10 | Robert Shorr | PHARMACEUTICAL COMPOUNDS |
| KR20150128687A (ko) | 2013-03-14 | 2015-11-18 | 샤이어 휴먼 지네틱 테라피즈 인크. | 메신저 rna의 정제 방법 |
| MX393573B (es) | 2013-03-14 | 2025-03-21 | Shire Human Genetic Therapies | Composiciones de acido ribonucleico mensajero del regulador transmembrana de fibrosis quistica y metodos y usos relacionados |
| CN103360437B (zh) * | 2013-04-27 | 2015-10-21 | 江苏教育学院 | 一种硫辛酸糖类衍生物及其制备方法和在制备抗肿瘤药物中的应用 |
| CN103497344B (zh) * | 2013-09-25 | 2015-09-23 | 深圳先进技术研究院 | 用于负载贵金属颗粒的纳米凝胶及其制备方法与应用 |
| EP3574923A1 (en) | 2013-10-22 | 2019-12-04 | Translate Bio, Inc. | Mrna therapy for phenylketonuria |
| JP6608815B2 (ja) | 2013-10-22 | 2019-11-20 | トランスレイト バイオ， インコーポレイテッド | アルギニノコハク酸合成酵素欠損症のｍＲＮＡ治療 |
| EP3636742B1 (en) | 2014-04-25 | 2025-11-05 | Translate Bio, Inc. | Methods for purification of messenger rna |
| ES2819175T3 (es) * | 2014-06-19 | 2021-04-15 | Rafael Pharmaceuticals Inc | Compuestos farmacéuticos |
| EP3188726B1 (en) | 2014-06-19 | 2019-08-07 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
| EP3585417B1 (en) | 2017-02-27 | 2023-02-22 | Translate Bio, Inc. | Method of making a codon-optimized cftr mrna |
| AU2018268859B2 (en) | 2017-05-16 | 2024-07-25 | Translate Bio, Inc. | Treatment of cystic fibrosis by delivery of codon-optimized mrna encoding CFTR |
| US11174500B2 (en) | 2018-08-24 | 2021-11-16 | Translate Bio, Inc. | Methods for purification of messenger RNA |
| WO2020106946A1 (en) | 2018-11-21 | 2020-05-28 | Translate Bio, Inc. | TREATMENT OF CYSTIC FIBROSIS BY DELIVERY OF NEBULIZED mRNA ENCODING CFTR |
| TW202114651A (zh) * | 2019-08-16 | 2021-04-16 | 美商拉斐爾製藥公司 | 用於治療癌症之方法及含有４，６—雙（苄硫基）己酸之藥物組成物 |
| EP4110308A4 (en) * | 2020-02-28 | 2024-03-20 | University Of Florida Research Foundation, Incorporated | ANTI-TUMOR IMMUNITY MODULATING COMPOUNDS AND METHOD FOR THE PRODUCTION THEREOF |
| TW202233172A (zh) * | 2020-11-03 | 2022-09-01 | 美商拉斐爾製藥公司 | 使用德弗米司特（ｄｅｖｉｍｉｓｔａｔ）治療膽道癌的治療方法及組合物 |
| CN119770650A (zh) * | 2025-01-09 | 2025-04-08 | 华中科技大学 | 一种硫辛酸-胆碱离子液体溶液及其制备方法和应用 |
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| WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
| US20050048008A1 (en) * | 2003-08-29 | 2005-03-03 | Bioderm Research | Antiaging Cosmetic Delivery Systems |
| JP2007077066A (ja) * | 2005-09-14 | 2007-03-29 | Shiseido Co Ltd | 不全角化抑制剤、毛穴縮小剤 |
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| GB758897A (en) | 1953-10-19 | 1956-10-10 | Merck & Co Inc | Thio-substituted aliphatic carboxylic acids and their preparation |
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| US3002011A (en) * | 1953-12-04 | 1961-09-26 | Merck & Co Inc | Intermediates and processes for producing alpha-lipoic acid |
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| US8263653B2 (en) * | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
| EP2139321B1 (en) * | 2007-04-18 | 2013-11-06 | Cornerstone Pharmaceuticals, Inc. | Lipoic acid derivatives |
| MX2009011165A (es) | 2007-04-18 | 2009-12-09 | Cornerstone Pharmaceuticals In | Formulaciones farmaceuticas que contienen derivados del acido lipoico. |
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2008
- 2008-04-17 MX MX2009011165A patent/MX2009011165A/es active IP Right Grant
- 2008-04-17 KR KR1020097023900A patent/KR101539785B1/ko not_active Expired - Fee Related
- 2008-04-17 AU AU2008242827A patent/AU2008242827B2/en not_active Ceased
- 2008-04-17 NZ NZ580973A patent/NZ580973A/en not_active IP Right Cessation
- 2008-04-17 CN CN200880017628.5A patent/CN101820875B/zh not_active Expired - Fee Related
- 2008-04-17 WO PCT/US2008/060650 patent/WO2008131114A2/en not_active Ceased
- 2008-04-17 US US12/105,100 patent/US20080262077A1/en not_active Abandoned
- 2008-04-17 BR BRPI0810439-5A patent/BRPI0810439B1/pt not_active IP Right Cessation
- 2008-04-17 PL PL08780538T patent/PL2144609T3/pl unknown
- 2008-04-17 PT PT87805388T patent/PT2144609E/pt unknown
- 2008-04-17 CA CA2684479A patent/CA2684479C/en active Active
- 2008-04-17 ES ES08780538.8T patent/ES2528414T3/es active Active
- 2008-04-17 EP EP08780538.8A patent/EP2144609B1/en not_active Not-in-force
- 2008-04-17 JP JP2010504247A patent/JP5480804B2/ja not_active Expired - Fee Related
- 2008-04-18 AR ARP080101607A patent/AR067309A1/es not_active Application Discontinuation
- 2008-04-18 TW TW097114308A patent/TWI459944B/zh not_active IP Right Cessation
- 2008-04-18 CL CL2008001124A patent/CL2008001124A1/es unknown
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- 2016-04-21 US US15/134,896 patent/US9872845B2/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5569670A (en) * | 1992-06-05 | 1996-10-29 | Asta Medica Aktiengesellschaft | Combination medications containing alpha-lipoic acid and related |
| WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
| US20050048008A1 (en) * | 2003-08-29 | 2005-03-03 | Bioderm Research | Antiaging Cosmetic Delivery Systems |
| JP2007077066A (ja) * | 2005-09-14 | 2007-03-29 | Shiseido Co Ltd | 不全角化抑制剤、毛穴縮小剤 |
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