EP2260019A4 - Modulation of enzymatic structure, activity, and/or expression level - Google Patents
Modulation of enzymatic structure, activity, and/or expression levelInfo
- Publication number
- EP2260019A4 EP2260019A4 EP08726395A EP08726395A EP2260019A4 EP 2260019 A4 EP2260019 A4 EP 2260019A4 EP 08726395 A EP08726395 A EP 08726395A EP 08726395 A EP08726395 A EP 08726395A EP 2260019 A4 EP2260019 A4 EP 2260019A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- modulation
- activity
- expression level
- enzymatic structure
- enzymatic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/385—Heterocyclic compounds having sulfur as a ring hetero atom having two or more sulfur atoms in the same ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/32—Esters of monothiocarboxylic acids having sulfur atoms of esterified thiocarboxyl groups bound to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/US2008/002853 WO2009110859A1 (en) | 2008-03-04 | 2008-03-04 | Modulation of enzymatic structure, activity, and/or expression level |
Publications (2)
Publication Number | Publication Date |
---|---|
EP2260019A1 EP2260019A1 (en) | 2010-12-15 |
EP2260019A4 true EP2260019A4 (en) | 2011-08-03 |
Family
ID=41056265
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
EP08726395A Withdrawn EP2260019A4 (en) | 2008-03-04 | 2008-03-04 | Modulation of enzymatic structure, activity, and/or expression level |
Country Status (10)
Country | Link |
---|---|
EP (1) | EP2260019A4 (en) |
JP (1) | JP2011513395A (en) |
KR (1) | KR20110004846A (en) |
CN (1) | CN102089276A (en) |
AU (1) | AU2008352076A1 (en) |
BR (1) | BRPI0821176A2 (en) |
CA (1) | CA2717511A1 (en) |
IL (1) | IL207943A0 (en) |
MX (1) | MX2010009673A (en) |
WO (1) | WO2009110859A1 (en) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8263653B2 (en) * | 2007-04-18 | 2012-09-11 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
EP2268278A4 (en) * | 2008-04-04 | 2011-11-09 | Shorr Robert | Pharmaceutical composition |
AU2014398232B2 (en) | 2014-06-19 | 2019-11-28 | Rafael Pharmaceuticals, Inc. | Pharmaceutical compounds |
WO2015195071A1 (en) | 2014-06-19 | 2015-12-23 | Robert Shorr | Pharmaceutical compounds |
WO2020132401A1 (en) * | 2018-12-20 | 2020-06-25 | Rafael Pharmaceuticals, Inc. | Oral therapy using 6,8-bis-benzylthio-octanoic acid |
Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679697A (en) * | 1993-11-26 | 1997-10-21 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors |
US5693664A (en) * | 1993-12-21 | 1997-12-02 | Asta Medica Aktiengesellschaft | Use of R-(+)-α-lipoic acid, R-(-)dihydrolipoic acid and metabolites in the form of the free acid or salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae |
WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
WO2000048594A1 (en) * | 1999-02-16 | 2000-08-24 | The Center For The Improvement Of Human Functioning International, Inc. | Use of lipoic acid combination with ascorbic acid in the treatment of cancer |
WO2000061143A1 (en) * | 1999-04-09 | 2000-10-19 | Antibioticos S.P.A. | The use of alpha lipoic acid in the antimetastatic treatment |
WO2006119355A2 (en) * | 2005-05-03 | 2006-11-09 | Albert Einstein College Of Medicine Of Yeshiva University | Mammalian hypothalamic nutrient modulation of glucose metabolism |
WO2008131114A2 (en) * | 2007-04-18 | 2008-10-30 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
WO2008131117A1 (en) * | 2007-04-18 | 2008-10-30 | Cornerstone Pharmaceuticals, Inc. | Lipoic acid derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1172110A3 (en) * | 2000-07-07 | 2003-09-17 | Basf Aktiengesellschaft | Use of lipoic acid as a bioavailaty enhancer of mineral salts |
US20020071234A1 (en) * | 2000-10-25 | 2002-06-13 | George Alexanian | Battery powered programmable remote switch controller |
-
2008
- 2008-03-04 AU AU2008352076A patent/AU2008352076A1/en not_active Abandoned
- 2008-03-04 KR KR1020107022085A patent/KR20110004846A/en not_active Application Discontinuation
- 2008-03-04 WO PCT/US2008/002853 patent/WO2009110859A1/en active Application Filing
- 2008-03-04 MX MX2010009673A patent/MX2010009673A/en unknown
- 2008-03-04 EP EP08726395A patent/EP2260019A4/en not_active Withdrawn
- 2008-03-04 CA CA2717511A patent/CA2717511A1/en not_active Abandoned
- 2008-03-04 BR BRPI0821176A patent/BRPI0821176A2/en not_active IP Right Cessation
- 2008-03-04 CN CN2008801288127A patent/CN102089276A/en active Pending
- 2008-03-04 JP JP2010549618A patent/JP2011513395A/en active Pending
-
2010
- 2010-09-02 IL IL207943A patent/IL207943A0/en unknown
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5679697A (en) * | 1993-11-26 | 1997-10-21 | Garnett; Merrill | Palladium complexes and methods for using same in the treatment of tumors |
US5693664A (en) * | 1993-12-21 | 1997-12-02 | Asta Medica Aktiengesellschaft | Use of R-(+)-α-lipoic acid, R-(-)dihydrolipoic acid and metabolites in the form of the free acid or salts or esters or amides for the preparation of drugs for the treatment of diabetes mellitus as well as of its sequelae |
WO2000024734A1 (en) * | 1998-10-26 | 2000-05-04 | The Research Foundation Of State University Of New York | Lipoic acid derivatives and their use in treatment of disease |
WO2000048594A1 (en) * | 1999-02-16 | 2000-08-24 | The Center For The Improvement Of Human Functioning International, Inc. | Use of lipoic acid combination with ascorbic acid in the treatment of cancer |
WO2000061143A1 (en) * | 1999-04-09 | 2000-10-19 | Antibioticos S.P.A. | The use of alpha lipoic acid in the antimetastatic treatment |
WO2006119355A2 (en) * | 2005-05-03 | 2006-11-09 | Albert Einstein College Of Medicine Of Yeshiva University | Mammalian hypothalamic nutrient modulation of glucose metabolism |
WO2008131114A2 (en) * | 2007-04-18 | 2008-10-30 | Cornerstone Pharmaceuticals, Inc. | Pharmaceutical formulations containing lipoic acid derivatives |
WO2008131117A1 (en) * | 2007-04-18 | 2008-10-30 | Cornerstone Pharmaceuticals, Inc. | Lipoic acid derivatives |
Non-Patent Citations (2)
Title |
---|
KOROTCHKINA LIOUBOV G ET AL: "R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase", FREE RADICAL RESEARCH, vol. 38, no. 10, October 2004 (2004-10-01), pages 1083 - 1092, XP008138351, ISSN: 1071-5762 * |
See also references of WO2009110859A1 * |
Also Published As
Publication number | Publication date |
---|---|
CN102089276A (en) | 2011-06-08 |
BRPI0821176A2 (en) | 2015-10-06 |
JP2011513395A (en) | 2011-04-28 |
MX2010009673A (en) | 2011-03-15 |
WO2009110859A1 (en) | 2009-09-11 |
AU2008352076A1 (en) | 2009-09-11 |
KR20110004846A (en) | 2011-01-14 |
IL207943A0 (en) | 2010-12-30 |
CA2717511A1 (en) | 2009-09-11 |
EP2260019A1 (en) | 2010-12-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
17P | Request for examination filed |
Effective date: 20100903 |
|
AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MT NL NO PL PT RO SE SI SK TR |
|
AX | Request for extension of the european patent |
Extension state: AL BA MK RS |
|
DAX | Request for extension of the european patent (deleted) | ||
A4 | Supplementary search report drawn up and despatched |
Effective date: 20110704 |
|
RIC1 | Information provided on ipc code assigned before grant |
Ipc: A61K 31/385 20060101ALI20110628BHEP Ipc: A61K 31/19 20060101ALI20110628BHEP Ipc: C07C 271/02 20060101AFI20110628BHEP |
|
RIN1 | Information on inventor provided before grant (corrected) |
Inventor name: ZACHAR, ZUZANA Inventor name: BOTEJU, LAKMAL, W. Inventor name: BINGHAM, PAUL Inventor name: BHASIN, RAJINDER |
|
17Q | First examination report despatched |
Effective date: 20121113 |
|
STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN |
|
18D | Application deemed to be withdrawn |
Effective date: 20130524 |