TWI444187B - 用於炎症及免疫相關用途之噻吩化合物 - Google Patents

用於炎症及免疫相關用途之噻吩化合物 Download PDF

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TWI444187B
TWI444187B TW095102770A TW95102770A TWI444187B TW I444187 B TWI444187 B TW I444187B TW 095102770 A TW095102770 A TW 095102770A TW 95102770 A TW95102770 A TW 95102770A TW I444187 B TWI444187 B TW I444187B
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Taiwan
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methyl
thiophen
phenyl
group
difluoro
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TW095102770A
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Chinese (zh)
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TW200716108A (en
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Lijun Sun
Shoujun Chen
Jun Jiang
Zhi-Qiang Xia
Yu Xie
Chih Yi Yu
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Synta Pharmaceuticals Corp
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    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/38—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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TW095102770A 2005-01-25 2006-01-25 用於炎症及免疫相關用途之噻吩化合物 TWI444187B (zh)

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US64677205P 2005-01-25 2005-01-25

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TW200716108A TW200716108A (en) 2007-05-01
TWI444187B true TWI444187B (zh) 2014-07-11

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US (1) US8802721B2 (enExample)
EP (1) EP1846388A4 (enExample)
JP (2) JP5221147B2 (enExample)
AU (1) AU2006208043B2 (enExample)
CA (1) CA2595000C (enExample)
TW (1) TWI444187B (enExample)
WO (1) WO2006081389A1 (enExample)

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EP2503997B1 (en) * 2009-11-23 2017-06-21 INSERM - Institut National de la Santé et de la Recherche Médicale Inhibitors of the pp1/gadd34 complex for the treatment of a condition requiring an immunosuppressive activity
US10703722B2 (en) 2010-04-27 2020-07-07 Calcimedica, Inc. Compounds that modulate intracellular calcium
EP2563759B1 (en) 2010-04-27 2022-04-06 Calcimedica, Inc. Compounds that modulate intracellular calcium
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