TWI437990B - Vx-950之醫藥用途 - Google Patents
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- TWI437990B TWI437990B TW094137981A TW94137981A TWI437990B TW I437990 B TWI437990 B TW I437990B TW 094137981 A TW094137981 A TW 094137981A TW 94137981 A TW94137981 A TW 94137981A TW I437990 B TWI437990 B TW I437990B
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/24011—Flaviviridae
- C12N2770/24211—Hepacivirus, e.g. hepatitis C virus, hepatitis G virus
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Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62354204P | 2004-10-29 | 2004-10-29 | |
| US67940205P | 2005-05-09 | 2005-05-09 | |
| US68209105P | 2005-05-17 | 2005-05-17 | |
| US72274605P | 2005-09-30 | 2005-09-30 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200630093A TW200630093A (en) | 2006-09-01 |
| TWI437990B true TWI437990B (zh) | 2014-05-21 |
Family
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| Application Number | Title | Priority Date | Filing Date |
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| TW094137981A TWI437990B (zh) | 2004-10-29 | 2005-10-28 | Vx-950之醫藥用途 |
| TW103100886A TW201424733A (zh) | 2004-10-29 | 2005-10-28 | 劑量型式 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
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| TW103100886A TW201424733A (zh) | 2004-10-29 | 2005-10-28 | 劑量型式 |
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| US (1) | US8431615B2 (enExample) |
| EP (2) | EP1819336A2 (enExample) |
| JP (2) | JP2008518943A (enExample) |
| KR (2) | KR20070085547A (enExample) |
| CN (1) | CN102988365A (enExample) |
| AU (1) | AU2005302361B2 (enExample) |
| CA (1) | CA2585647A1 (enExample) |
| IL (1) | IL182847A0 (enExample) |
| MX (1) | MX2007005179A (enExample) |
| MY (1) | MY141025A (enExample) |
| NO (1) | NO20072733L (enExample) |
| RU (1) | RU2393863C2 (enExample) |
| TW (2) | TWI437990B (enExample) |
| WO (1) | WO2006050250A2 (enExample) |
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| NZ335276A (en) * | 1996-10-18 | 2000-09-29 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis C virus (HCV) NS3 (Non Structural Protein 3) protease |
| MY148123A (en) * | 2003-09-05 | 2013-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hcv ns3-ns4a protease |
| US20120201883A1 (en) * | 2004-05-21 | 2012-08-09 | Accu-Break Technologies, Inc | Antiviral compositons |
| WO2005123076A2 (en) * | 2004-06-08 | 2005-12-29 | Vertex Pharmaceuticals, Inc. | Pharmaceutical compositions |
| US8119602B2 (en) * | 2005-06-02 | 2012-02-21 | Schering Corporation | Administration of HCV protease inhibitors in combination with food to improve bioavailability |
| US20060287248A1 (en) * | 2005-06-02 | 2006-12-21 | Schering Corporation | Asymmetric dosing methods |
| US7772178B2 (en) * | 2005-06-02 | 2010-08-10 | Schering Corporation | Pharmaceutical formulations and methods of treatment using the same |
| ES2401661T3 (es) * | 2005-08-02 | 2013-04-23 | Vertex Pharmaceuticals Incorporated | Inhibidores de serina proteasas |
| US8399615B2 (en) | 2005-08-19 | 2013-03-19 | Vertex Pharmaceuticals Incorporated | Processes and intermediates |
| US7964624B1 (en) | 2005-08-26 | 2011-06-21 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| AR055395A1 (es) * | 2005-08-26 | 2007-08-22 | Vertex Pharma | Compuestos inhibidores de la actividad de la serina proteasa ns3-ns4a del virus de la hepatitis c |
| EP1991229A2 (en) | 2006-02-27 | 2008-11-19 | Vertex Pharmaceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| JP2009531315A (ja) | 2006-03-16 | 2009-09-03 | バーテックス ファーマシューティカルズ インコーポレイテッド | 重水素化ｃ型肝炎プロテアーゼインヒビター |
| EP2518079A3 (en) | 2006-04-11 | 2012-12-12 | Novartis AG | HCV/HIV inhibitors and their uses |
| CA2666814A1 (en) * | 2006-08-21 | 2008-05-29 | United Therapeutics Corporation | Combination therapy for treatment of viral infections |
| US8575208B2 (en) * | 2007-02-27 | 2013-11-05 | Vertex Pharmaceuticals Incorporated | Inhibitors of serine proteases |
| EA200970806A1 (ru) * | 2007-02-27 | 2010-08-30 | Вертекс Фармасьютикалз Инкорпорейтед | Сокристаллы и содержащие их фармацевтические композиции |
| EP2157974A1 (en) * | 2007-05-21 | 2010-03-03 | Vertex Pharmceuticals Incorporated | Dose forms comprising vx- 950 and their dosage regimen |
| EP2436682A1 (en) * | 2007-08-30 | 2012-04-04 | Vertex Pharmceuticals Incorporated | Co-crystals and pharmaceutical compositions comprising the same |
| KR101396696B1 (ko) * | 2007-10-10 | 2014-05-16 | 노파르티스 아게 | 스피로피롤리딘, 및 ｈｃｖ 및 ｈｉｖ 감염에 대한 그의 용도 |
| EP2214682A2 (en) * | 2007-11-05 | 2010-08-11 | Vertex Pharmaceuticals Incorporated | Hcv combination therapies comprising vx-950, peg-ifn and ribavirin |
| JP5750266B2 (ja) * | 2008-02-28 | 2015-07-15 | アッヴィ・インコーポレイテッド | 錠剤およびその調製 |
| EP2280709A1 (en) * | 2008-04-23 | 2011-02-09 | Vertex Pharmaceuticals Incorporated | Treatment of hepatitis c virus infections with telaprevir (vx-950) in patients non-responsive to treatment with pegylated interfer0n-alpha-2a/2b and ribavirin |
| US20100069821A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable medicament release-sites final dosage form |
| US20100068152A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo modifiable particle or polymeric based final dosage form |
| US20100068235A1 (en) * | 2008-09-16 | 2010-03-18 | Searete LLC, a limited liability corporation of Deleware | Individualizable dosage form |
| US20100068153A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo activatable final dosage form |
| US20100069887A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Multiple chamber ex vivo adjustable-release final dosage form |
| US20100068233A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Modifiable dosage form |
| US20100068266A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Ex vivo-modifiable multiple-release state final dosage form |
| US20100068275A1 (en) * | 2008-09-16 | 2010-03-18 | Searete Llc, A Limited Liability Corporation Of The State Of Delaware | Personalizable dosage form |
| US20100068254A1 (en) * | 2008-09-16 | 2010-03-18 | Mahalaxmi Gita Bangera | Modifying a medicament availability state of a final dosage form |
| KR20110074870A (ko) * | 2008-09-24 | 2011-07-04 | 버텍스 파마슈티칼스 인코포레이티드 | 간염을 치료하기 위한 ｐｅｇ-인터페론, 리바비린 및 ｖｘ-950을 포함하는 치료 요법 |
| EP2358439A1 (en) * | 2008-11-05 | 2011-08-24 | Vertex Pharmaceuticals Incorporated | Methods for treating hepatitis c virus infection |
| DE102008064038A1 (de) * | 2008-12-22 | 2010-07-01 | Ksb Aktiengesellschaft | Vorrichtung und Verfahren zur Detektion von Belägen |
| EP2396028A2 (en) * | 2009-02-12 | 2011-12-21 | Vertex Pharmceuticals Incorporated | Hcv combination therapies comprising pegylated interferon, ribavirin and telaprevir |
| US8512690B2 (en) | 2009-04-10 | 2013-08-20 | Novartis Ag | Derivatised proline containing peptide compounds as protease inhibitors |
| AU2011210795A1 (en) | 2010-01-29 | 2012-08-02 | Vertex Pharmaceuticals Incorporated | Therapies for treating Hepatitis C virus infection |
| WO2011156545A1 (en) | 2010-06-09 | 2011-12-15 | Vertex Pharmaceuticals Incorporated | Viral dynamic model for hcv combination therapy |
| EP2593105A1 (en) | 2010-07-14 | 2013-05-22 | Vertex Pharmaceuticals Incorporated | Palatable pharmaceutical composition comprising vx-950 |
| CA2815416A1 (en) | 2010-10-21 | 2012-04-26 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
| WO2012109646A1 (en) | 2011-02-11 | 2012-08-16 | Vertex Pharmaceuticals Incorporated | Treatment of hcv in hiv infection patients |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| DE112012003510T5 (de) | 2011-10-21 | 2015-03-19 | Abbvie Inc. | Verfahren zur Behandlung von HCV umfassend mindestens zwei direkt wirkende antivirale Wirkstoffe, Ribavirin aber nicht Interferon |
| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| CN104023726A (zh) | 2011-10-21 | 2014-09-03 | 艾伯维公司 | 用于治疗hcv的一种或多种daa的联合治疗(例如，与abt-072或abt-333) |
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| WO2014015217A1 (en) | 2012-07-19 | 2014-01-23 | Vertex Pharmaceuticals Incorporated | Biomarkers for hcv infected patients |
| JP7129703B2 (ja) | 2016-04-28 | 2022-09-02 | エモリー ユニバーシティー | アルキン含有ヌクレオチド及びヌクレオシド治療組成物並びにそれらに関連した使用 |
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| DE69334250D1 (de) | 1992-12-29 | 2009-01-29 | Abbott Lab | Verfahren und Intermediate zur Herstellung von retroviralen Proteasehemmern |
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| WO2005123076A2 (en) * | 2004-06-08 | 2005-12-29 | Vertex Pharmaceuticals, Inc. | Pharmaceutical compositions |
-
2005
- 2005-10-28 MY MYPI20055106A patent/MY141025A/en unknown
- 2005-10-28 TW TW094137981A patent/TWI437990B/zh not_active IP Right Cessation
- 2005-10-28 TW TW103100886A patent/TW201424733A/zh unknown
- 2005-10-31 MX MX2007005179A patent/MX2007005179A/es unknown
- 2005-10-31 WO PCT/US2005/039240 patent/WO2006050250A2/en not_active Ceased
- 2005-10-31 JP JP2007539241A patent/JP2008518943A/ja active Pending
- 2005-10-31 US US11/264,746 patent/US8431615B2/en not_active Expired - Fee Related
- 2005-10-31 KR KR1020077012147A patent/KR20070085547A/ko not_active Ceased
- 2005-10-31 CN CN2012104136092A patent/CN102988365A/zh active Pending
- 2005-10-31 KR KR1020137009594A patent/KR20130063022A/ko not_active Ceased
- 2005-10-31 RU RU2007119725/14A patent/RU2393863C2/ru not_active IP Right Cessation
- 2005-10-31 AU AU2005302361A patent/AU2005302361B2/en not_active Ceased
- 2005-10-31 EP EP05815054A patent/EP1819336A2/en not_active Withdrawn
- 2005-10-31 EP EP11184992A patent/EP2500021A1/en not_active Withdrawn
- 2005-10-31 CA CA002585647A patent/CA2585647A1/en not_active Abandoned
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2007
- 2007-04-29 IL IL182847A patent/IL182847A0/en unknown
- 2007-05-29 NO NO20072733A patent/NO20072733L/no not_active Application Discontinuation
-
2013
- 2013-01-09 JP JP2013001638A patent/JP2013060474A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JP2008518943A (ja) | 2008-06-05 |
| TW201424733A (zh) | 2014-07-01 |
| US20060105978A1 (en) | 2006-05-18 |
| IL182847A0 (en) | 2007-09-20 |
| KR20130063022A (ko) | 2013-06-13 |
| CA2585647A1 (en) | 2006-05-11 |
| CN102988365A (zh) | 2013-03-27 |
| US8431615B2 (en) | 2013-04-30 |
| JP2013060474A (ja) | 2013-04-04 |
| MY141025A (en) | 2010-02-25 |
| TW200630093A (en) | 2006-09-01 |
| RU2007119725A (ru) | 2008-12-20 |
| WO2006050250A3 (en) | 2006-07-27 |
| EP2500021A1 (en) | 2012-09-19 |
| RU2393863C2 (ru) | 2010-07-10 |
| AU2005302361B2 (en) | 2011-11-17 |
| NO20072733L (no) | 2007-05-29 |
| EP1819336A2 (en) | 2007-08-22 |
| MX2007005179A (es) | 2008-03-06 |
| WO2006050250A2 (en) | 2006-05-11 |
| AU2005302361A1 (en) | 2006-05-11 |
| KR20070085547A (ko) | 2007-08-27 |
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| MM4A | Annulment or lapse of patent due to non-payment of fees |