TWI434838B - 2-[6-(3-胺基-哌啶-l-基)-3-甲基-2,4-二側氧基-3,4-二氫-2H-嘧啶-l-基甲基]-4-氟-苯甲腈之用途 - Google Patents

Info

Publication number

TWI434838B

TWI434838B TW096134051A TW96134051A TWI434838B TW I434838 B TWI434838 B TW I434838B TW 096134051 A TW096134051 A TW 096134051A TW 96134051 A TW96134051 A TW 96134051A TW I434838 B TWI434838 B TW I434838B

Authority

TW

Taiwan

Prior art keywords

compound

administered

diabetic

methyl

administration

Prior art date

2006-09-13

Links

• Espacenet
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• IWYJYHUNXVAVAA-UHFFFAOYSA-N 2-[[6-(3-aminopiperidin-1-yl)-3-methyl-2,4-dioxopyrimidin-1-yl]methyl]-4-fluorobenzonitrile Chemical compound C=1C(F)=CC=C(C#N)C=1CN1C(=O)N(C)C(=O)C=C1N1CCCC(N)C1 IWYJYHUNXVAVAA-UHFFFAOYSA-N 0.000 title 1
• 150000001875 compounds Chemical class 0.000 claims description 396
• 150000003839 salts Chemical class 0.000 claims description 52
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• 201000010099 disease Diseases 0.000 claims description 26
• 239000012458 free base Substances 0.000 claims description 18
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• 238000004519 manufacturing process Methods 0.000 claims description 8
• 239000003814 drug Substances 0.000 claims description 5
• 150000003890 succinate salts Chemical class 0.000 claims description 3
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• 230000003178 anti-diabetic effect Effects 0.000 description 112
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• 239000008194 pharmaceutical composition Substances 0.000 description 75
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• HYAFETHFCAUJAY-UHFFFAOYSA-N pioglitazone Chemical compound N1=CC(CC)=CC=C1CCOC(C=C1)=CC=C1CC1C(=O)NC(=O)S1 HYAFETHFCAUJAY-UHFFFAOYSA-N 0.000 description 63
• 102100025012 Dipeptidyl peptidase 4 Human genes 0.000 description 60
• 230000000694 effects Effects 0.000 description 48
• 108010067722 Dipeptidyl Peptidase 4 Proteins 0.000 description 46
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical group N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 45
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• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 11
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