TWI411431B - 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 - Google Patents

有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 Download PDF

Info

Publication number
TWI411431B
TWI411431B TW094123873A TW94123873A TWI411431B TW I411431 B TWI411431 B TW I411431B TW 094123873 A TW094123873 A TW 094123873A TW 94123873 A TW94123873 A TW 94123873A TW I411431 B TWI411431 B TW I411431B
Authority
TW
Taiwan
Prior art keywords
group
alkyl
compound
cancer
aryl
Prior art date
Application number
TW094123873A
Other languages
English (en)
Chinese (zh)
Other versions
TW200616615A (en
Inventor
Ralph A Zingaro
Hatice Duzkale
Emil J Freireich
Hagop Kantarjian
Merida Sotelo-Lerma
Srdan Verstovsek
Mingzhang Gao
Original Assignee
Texas A & M Univ Sys
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Texas A & M Univ Sys, Univ Texas filed Critical Texas A & M Univ Sys
Publication of TW200616615A publication Critical patent/TW200616615A/zh
Application granted granted Critical
Publication of TWI411431B publication Critical patent/TWI411431B/zh

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/72Aliphatic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/555Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/08Drugs for disorders of the urinary system of the prostate
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/08Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06Antianaemics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/74Aromatic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/66Arsenic compounds
    • C07F9/70Organo-arsenic compounds
    • C07F9/80Heterocyclic compounds
    • C07F9/82Arsenic compounds containing one or more pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Neurology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
TW094123873A 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物 TWI411431B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US58859604P 2004-07-16 2004-07-16

Publications (2)

Publication Number Publication Date
TW200616615A TW200616615A (en) 2006-06-01
TWI411431B true TWI411431B (zh) 2013-10-11

Family

ID=35414967

Family Applications (3)

Application Number Title Priority Date Filing Date
TW094123873A TWI411431B (zh) 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
TW103121164A TW201440760A (zh) 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
TW102125370A TW201350113A (zh) 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Family Applications After (2)

Application Number Title Priority Date Filing Date
TW103121164A TW201440760A (zh) 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
TW102125370A TW201350113A (zh) 2004-07-16 2005-07-14 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Country Status (11)

Country Link
US (2) US7405314B2 (enExample)
EP (1) EP1771459A2 (enExample)
JP (3) JP5618461B2 (enExample)
KR (5) KR20140136525A (enExample)
CN (3) CN105777811A (enExample)
AU (1) AU2005274926B2 (enExample)
CA (2) CA2574032C (enExample)
HK (1) HK1204476A1 (enExample)
IL (2) IL180729A (enExample)
TW (3) TWI411431B (enExample)
WO (1) WO2006020048A2 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003207455B2 (en) 2002-01-07 2007-09-20 Board Of Regents, The University Of Texas System S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer
US7628810B2 (en) 2003-05-28 2009-12-08 Acufocus, Inc. Mask configured to maintain nutrient transport without producing visible diffraction patterns
TWI411431B (zh) * 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
WO2007027344A2 (en) 2005-07-29 2007-03-08 Ziopharm Oncology, Inc. Compounds and methods for the treatment of cancer
AU2007204831B2 (en) * 2006-01-13 2013-10-03 The Texas A & M University System Compounds and methods for the treatment of cancer
RU2318519C2 (ru) * 2006-03-06 2008-03-10 ФГУ Ростовский научно-исследовательский онкологический институт Росздрава Способ химиотерапии острого лейкоза
TW200829261A (en) * 2006-09-29 2008-07-16 Ziopharm Oncology Inc Method for controlling angiogenesis in animals
EP2209480B1 (en) 2007-11-02 2012-09-05 Ziopharm Oncology, Inc. Combination therapy with organic arsenicals
US20100331403A1 (en) * 2007-12-12 2010-12-30 Amedio Jr John C Compounds and methods for the treatment of cancer
ES2703740T3 (es) * 2008-08-20 2019-03-12 Solasia Pharma K K Compuestos de organoarsénico y procedimientos para el tratamiento del cáncer
CN102060722B (zh) * 2009-05-01 2014-06-11 常州高新技术产业开发区三维工业技术研究所有限公司 一种含砷化合物及其制备方法和用途
CN102448404B (zh) 2009-08-13 2015-06-10 阿库福库斯公司 掩盖型眼内植入物和透镜
US10004593B2 (en) 2009-08-13 2018-06-26 Acufocus, Inc. Intraocular lens with elastic mask
JP2014516075A (ja) 2011-06-06 2014-07-07 シェブロン フィリップス ケミカル カンパニー エルピー 癌治療のためのメタロセン化合物の使用
WO2013082545A1 (en) 2011-12-02 2013-06-06 Acufocus, Inc. Ocular mask having selective spectral transmission
US9427922B2 (en) 2013-03-14 2016-08-30 Acufocus, Inc. Process for manufacturing an intraocular lens with an embedded mask
TWI617305B (zh) * 2013-12-05 2018-03-11 蘇愛康制藥有限公司 治療癌症的化合物及其應用程序
GB201418491D0 (en) * 2014-10-17 2014-12-03 Monfort University De Compounds
JP2017534404A (ja) 2014-11-19 2017-11-24 アキュフォーカス・インコーポレーテッド 老眼を治療するための割断性マスク
WO2017062316A1 (en) 2015-10-05 2017-04-13 Acufocus, Inc. Methods of molding intraocular lenses
CA3005891C (en) 2015-11-24 2023-12-12 Acufocus, Inc. Toric small aperture intraocular lens with extended depth of focus
CN105330701B (zh) * 2015-11-27 2017-05-31 昆明医科大学 一种含砷化合物及其制备方法和应用
US11364110B2 (en) 2018-05-09 2022-06-21 Acufocus, Inc. Intraocular implant with removable optic

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034095A1 (en) * 2002-01-07 2004-02-19 Zingaro Ralph A. S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1391206B1 (en) 1997-10-15 2008-07-02 Polarx Biopharmaceuticals, Inc. Pharmaceutical compositions comprising arsenic trioxide for the treatment of non-Hodgkin's lymphoma
ID25622A (id) 1997-11-10 2000-10-19 Sloan Kettering Inst Cancer Proses untuk memproduksi formulasi arsenat trioksida dan metoda untuk mengobati kanker dengan menggunakan arsenat trioksida atau melarsoprol
CN1233476A (zh) 1998-04-24 1999-11-03 陆道培 治疗急性白血病的药物及其制备方法
EP1002537A1 (en) 1998-10-30 2000-05-24 Assistance Publique, Hopitaux De Paris Use of melarsoprol for the manufacture of a medicament for treating B-cell lymphoproliferative diseases, such as multiple myeloma
US6191123B1 (en) 1999-03-19 2001-02-20 Parker Hughes Institute Organic-arsenic compounds
CA2406081C (en) 2000-04-26 2009-12-22 Oregon Health Sciences University Administration of a thiol-based chemoprotectant compound
TWI411431B (zh) * 2004-07-16 2013-10-11 Texas A & M Univ Sys 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040034095A1 (en) * 2002-01-07 2004-02-19 Zingaro Ralph A. S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Also Published As

Publication number Publication date
WO2006020048A3 (en) 2006-08-24
IL180729A (en) 2012-03-29
AU2005274926A1 (en) 2006-02-23
KR101252866B1 (ko) 2013-04-10
JP5745660B2 (ja) 2015-07-08
CA2777473C (en) 2013-08-27
US20060128682A1 (en) 2006-06-15
KR20070046120A (ko) 2007-05-02
HK1204476A1 (en) 2015-11-20
KR20140136525A (ko) 2014-11-28
TW201440760A (zh) 2014-11-01
CN101076533B (zh) 2013-11-06
US20080090793A1 (en) 2008-04-17
CA2574032C (en) 2015-02-24
JP2008506710A (ja) 2008-03-06
TW200616615A (en) 2006-06-01
TW201350113A (zh) 2013-12-16
KR20140013110A (ko) 2014-02-04
CN101076533A (zh) 2007-11-21
KR20130095857A (ko) 2013-08-28
AU2005274926B2 (en) 2011-04-28
EP1771459A2 (en) 2007-04-11
CN105777811A (zh) 2016-07-20
CA2777473A1 (en) 2006-02-23
WO2006020048A2 (en) 2006-02-23
WO2006020048B1 (en) 2006-10-19
JP2012051919A (ja) 2012-03-15
US7405314B2 (en) 2008-07-29
JP2014122233A (ja) 2014-07-03
JP5618461B2 (ja) 2014-11-05
IL180729A0 (en) 2007-06-03
CN104163833A (zh) 2014-11-26
KR20130001323A (ko) 2013-01-03
IL215896A0 (en) 2011-12-29
CA2574032A1 (en) 2006-02-23

Similar Documents

Publication Publication Date Title
TWI411431B (zh) 有機砷化合物、其用於治療癌症之用途及包含其之醫藥組成物
JP5603593B2 (ja) 癌治療薬としての、s−ジメチルアルシノ−チオコハク酸、s−ジメチルアルシノ−2−チオ安息香酸、s−(ジメチルアルシノ)グルタチオン
AU2011204901B2 (en) Compounds and methods for treatment of cancer
AU2007249110C1 (en) S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatment for cancer
HK1166959A (en) S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees