TWI405573B - 維生素-受體結合性藥物輸送共軛物中間物及製備方法 - Google Patents

維生素-受體結合性藥物輸送共軛物中間物及製備方法 Download PDF

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TWI405573B
TWI405573B TW101108172A TW101108172A TWI405573B TW I405573 B TWI405573 B TW I405573B TW 101108172 A TW101108172 A TW 101108172A TW 101108172 A TW101108172 A TW 101108172A TW I405573 B TWI405573 B TW I405573B
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Taiwan
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group
linking group
drug
vitamin
derivative
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TW101108172A
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Chinese (zh)
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TW201231054A (en
Inventor
Apparao Satyam
Iontcho Radoslavov Vlahov
Stephen J Howard
Christopher Paul Leamon
Hari Krishna Santhapuram
Matthew A Parker
Joseph Anand Reddy
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Endocyte Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/65—Peptidic linkers, binders or spacers, e.g. peptidic enzyme-labile linkers
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Pulmonology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Hematology (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW101108172A 2003-01-27 2004-01-27 維生素-受體結合性藥物輸送共軛物中間物及製備方法 TWI405573B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US44284503P 2003-01-27 2003-01-27
US49211903P 2003-08-01 2003-08-01
US51618803P 2003-10-31 2003-10-31

Publications (2)

Publication Number Publication Date
TW201231054A TW201231054A (en) 2012-08-01
TWI405573B true TWI405573B (zh) 2013-08-21

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Family Applications (3)

Application Number Title Priority Date Filing Date
TW101108172A TWI405573B (zh) 2003-01-27 2004-01-27 維生素-受體結合性藥物輸送共軛物中間物及製備方法
TW093101735A TWI367096B (en) 2003-01-27 2004-01-27 Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
TW102113366A TWI492750B (zh) 2003-01-27 2004-01-27 維生素-受體結合性藥物輸送共軛物、醫藥組合物、用途及製備方法

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Application Number Title Priority Date Filing Date
TW093101735A TWI367096B (en) 2003-01-27 2004-01-27 Vitamin-receptor binding drug delivery conjugates and pharmaceutical compositions
TW102113366A TWI492750B (zh) 2003-01-27 2004-01-27 維生素-受體結合性藥物輸送共軛物、醫藥組合物、用途及製備方法

Country Status (14)

Country Link
US (6) US7601332B2 (enExample)
EP (4) EP1592457B1 (enExample)
JP (4) JP5576007B2 (enExample)
AR (1) AR042942A1 (enExample)
AU (1) AU2004210136C1 (enExample)
CA (1) CA2512867C (enExample)
CY (1) CY1113258T1 (enExample)
DK (1) DK1592457T3 (enExample)
ES (1) ES2395082T3 (enExample)
IL (2) IL169469A (enExample)
NZ (1) NZ541846A (enExample)
PT (1) PT1592457E (enExample)
TW (3) TWI405573B (enExample)
WO (1) WO2004069159A2 (enExample)

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EP2266622A3 (en) 2004-08-26 2012-06-20 Piramal Life Sciences Limited Prodrugs containing novel bio-cleavable linkers
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CN101128152A (zh) * 2004-12-23 2008-02-20 普渡研究基金会 发射正电子段层成像方法
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