TWI403586B - 用於偵測目標反應與治療黃病毒感染症狀之化合物及方法 - Google Patents

用於偵測目標反應與治療黃病毒感染症狀之化合物及方法 Download PDF

Info

Publication number
TWI403586B
TWI403586B TW098110058A TW98110058A TWI403586B TW I403586 B TWI403586 B TW I403586B TW 098110058 A TW098110058 A TW 098110058A TW 98110058 A TW98110058 A TW 98110058A TW I403586 B TWI403586 B TW I403586B
Authority
TW
Taiwan
Prior art keywords
clec5a
dvlr1
receptor
binding
fusion protein
Prior art date
Application number
TW098110058A
Other languages
English (en)
Chinese (zh)
Other versions
TW201000636A (en
Inventor
Shie Liang Hsieh
Chi Huey Wong
Tsui Ling Hsu
Szu Ting Chen
Original Assignee
Academia Sinica
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Academia Sinica filed Critical Academia Sinica
Publication of TW201000636A publication Critical patent/TW201000636A/zh
Application granted granted Critical
Publication of TWI403586B publication Critical patent/TWI403586B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/18—Togaviridae; Flaviviridae
    • G01N2333/183—Flaviviridae, e.g. pestivirus, mucosal disease virus, bovine viral diarrhoea virus, classical swine fever virus (hog cholera virus) or border disease virus
    • G01N2333/185—Flaviviruses or Group B arboviruses, e.g. yellow fever virus, japanese encephalitis, tick-borne encephalitis, dengue
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW098110058A 2008-03-27 2009-03-27 用於偵測目標反應與治療黃病毒感染症狀之化合物及方法 TWI403586B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/079,576 US7943134B2 (en) 2005-08-31 2008-03-27 Compositions and methods for identifying response targets and treating flavivirus infection responses

Publications (2)

Publication Number Publication Date
TW201000636A TW201000636A (en) 2010-01-01
TWI403586B true TWI403586B (zh) 2013-08-01

Family

ID=39722300

Family Applications (1)

Application Number Title Priority Date Filing Date
TW098110058A TWI403586B (zh) 2008-03-27 2009-03-27 用於偵測目標反應與治療黃病毒感染症狀之化合物及方法

Country Status (9)

Country Link
US (2) US7943134B2 (https=)
EP (1) EP2257806A4 (https=)
JP (1) JP2011519414A (https=)
CN (1) CN102084250B (https=)
AU (1) AU2008353452A1 (https=)
BR (1) BRPI0822472A2 (https=)
GB (1) GB2458715A (https=)
TW (1) TWI403586B (https=)
WO (1) WO2009120225A1 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8354127B2 (en) * 2008-02-12 2013-01-15 Academia Sinica Structure and bioactivity of the polysaccharides and oligomers in medicinal plant Dendrobium huoshanense
WO2014059442A2 (en) 2012-10-12 2014-04-17 Arizona Board Agents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Antibody based reagents that specifically recognize toxic oligomeric forms of tau
WO2014183469A1 (zh) * 2013-05-16 2014-11-20 清华大学 一种用于登革热预防和/或治疗的疫苗
US9212217B2 (en) 2014-02-11 2015-12-15 Visterra, Inc. Antibody molecules to dengue virus and uses thereof
TWI763660B (zh) 2016-03-25 2022-05-11 美商威特拉公司 登革病毒的抗體分子之配方設計
WO2018170190A1 (en) * 2017-03-16 2018-09-20 Academia Sinica Methods of diagnosing viral infection
CN113573699A (zh) * 2019-01-08 2021-10-29 乔治亚大学研究基金会 靶向纳米颗粒以及它们的与真菌感染有关的用途
CN113122628B (zh) * 2019-12-30 2023-08-11 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用
CN111650308B (zh) * 2020-07-13 2022-10-14 贵州中医药大学 一种金钗石斛花的hplc指纹图谱构建方法
US11197910B1 (en) * 2020-08-19 2021-12-14 Vitruviae LLC Fusion proteins for the diagnosis, prophylaxis and treatment of infectious diseases
CN113713105A (zh) * 2021-09-13 2021-11-30 中国人民解放军军事科学院军事医学研究院 用于抑制clec5a的物质在制备治疗和/或预防乙型病毒性肝炎的药物中的应用
CN115029789A (zh) * 2022-05-31 2022-09-09 南通大学 DC-SIGN的shRNA库的构建及其在原发性肝癌中的应用
CN115804362A (zh) * 2023-02-08 2023-03-17 中国医学科学院医学生物学研究所 一种IFN-α/βR-/-小鼠抗体依赖性增强感染的注射液及其制备方法
CN118515783B (zh) * 2024-06-06 2024-11-08 威瑞生物科技(昆明)有限责任公司 新冠病毒N蛋白和编码S1抗原mRNA分子结合的仿生病毒结构疫苗及其制备方法
CN119075281A (zh) * 2024-08-27 2024-12-06 上海瑞健未来生物科技有限公司 动静两用的间歇性高低氧训练仪、训练方法及终端

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806691A (en) * 2005-08-31 2008-02-01 Academia Sinica Methods and reagents for the analysis and purification of polysaccharides

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4217344A (en) 1976-06-23 1980-08-12 L'oreal Compositions containing aqueous dispersions of lipid spheres
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
US4186183A (en) 1978-03-29 1980-01-29 The United States Of America As Represented By The Secretary Of The Army Liposome carriers in chemotherapy of leishmaniasis
US4261975A (en) 1979-09-19 1981-04-14 Merck & Co., Inc. Viral liposome particle
US4485054A (en) 1982-10-04 1984-11-27 Lipoderm Pharmaceuticals Limited Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV)
US4501728A (en) 1983-01-06 1985-02-26 Technology Unlimited, Inc. Masking of liposomes from RES recognition
US4946787A (en) 1985-01-07 1990-08-07 Syntex (U.S.A.) Inc. N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
US5506337A (en) 1985-03-15 1996-04-09 Antivirals Inc. Morpholino-subunit combinatorial library and method
US4774085A (en) 1985-07-09 1988-09-27 501 Board of Regents, Univ. of Texas Pharmaceutical administration systems containing a mixture of immunomodulators
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US5010175A (en) 1988-05-02 1991-04-23 The Regents Of The University Of California General method for producing and selecting peptides with specific properties
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
ATE157012T1 (de) 1989-11-03 1997-09-15 Univ Vanderbilt Verfahren zur in vivo-verabreichung von funktionsfähigen fremden genen
US5270163A (en) 1990-06-11 1993-12-14 University Research Corporation Methods for identifying nucleic acid ligands
IE66205B1 (en) 1990-06-14 1995-12-13 Paul A Bartlett Polypeptide analogs
US5650489A (en) 1990-07-02 1997-07-22 The Arizona Board Of Regents Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
US5288514A (en) 1992-09-14 1994-02-22 The Regents Of The University Of California Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support
US5519134A (en) 1994-01-11 1996-05-21 Isis Pharmaceuticals, Inc. Pyrrolidine-containing monomers and oligomers
US5593853A (en) 1994-02-09 1997-01-14 Martek Corporation Generation and screening of synthetic drug libraries
US5539083A (en) 1994-02-23 1996-07-23 Isis Pharmaceuticals, Inc. Peptide nucleic acid combinatorial libraries and improved methods of synthesis
US5525735A (en) 1994-06-22 1996-06-11 Affymax Technologies Nv Methods for synthesizing diverse collections of pyrrolidine compounds
US5549974A (en) 1994-06-23 1996-08-27 Affymax Technologies Nv Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof
US5820873A (en) 1994-09-30 1998-10-13 The University Of British Columbia Polyethylene glycol modified ceramide lipids and liposome uses thereof
US5885613A (en) 1994-09-30 1999-03-23 The University Of British Columbia Bilayer stabilizing components and their use in forming programmable fusogenic liposomes
US5753613A (en) 1994-09-30 1998-05-19 Inex Pharmaceuticals Corporation Compositions for the introduction of polyanionic materials into cells
US5804162A (en) 1995-06-07 1998-09-08 Alliance Pharmaceutical Corp. Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients
CA2245835A1 (en) 1995-06-14 1997-01-03 The Regents Of The University Of California Novel high affinity human antibodies to tumor antigens
US5811097A (en) 1995-07-25 1998-09-22 The Regents Of The University Of California Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling
US5569588A (en) 1995-08-09 1996-10-29 The Regents Of The University Of California Methods for drug screening
US6416973B1 (en) 1997-08-01 2002-07-09 Schering Corporation Nucleic acids encoding mammalian cell membrane protein MDL-1
WO2002081628A2 (en) 2001-04-05 2002-10-17 Ribozyme Pharmaceuticals, Incorporated Modulation of gene expression associated with inflammation proliferation and neurite outgrowth, using nucleic acid based technologies
GB0112649D0 (en) 2001-05-24 2001-07-18 Isis Innovation Macrophage receptor
CA2454226A1 (en) 2001-07-17 2003-01-30 University Of Virginia Patent Foundation Improved heteropolymer complexes and methods for their use
US20040219142A1 (en) 2002-07-19 2004-11-04 Abbott Laboratories S.A. Treatment of skin and nail disorders using TNFalpha inhibitors
DE60327237D1 (de) 2002-11-05 2009-05-28 Pasteur Institut Dc-sign blockern und deren verwendung zur vorbeugung oder behandlung von viraleninfektionen
JP2008518629A (ja) 2004-11-08 2008-06-05 シェーリング コーポレイション Ｍｄｌ−１の腫瘍との関連およびその方法
AR059193A1 (es) * 2006-01-31 2008-03-12 Bayer Schering Pharma Ag Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias
CA2685015A1 (en) * 2007-04-23 2008-11-06 Schering Corporation Anti-mdl-1 antibodies

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200806691A (en) * 2005-08-31 2008-02-01 Academia Sinica Methods and reagents for the analysis and purification of polysaccharides

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Daniel L. Barber, E. John Wherry, David Masopust, Baogong Zhu, James P. Allison, Arlene H. Sharpe, Gordon J. Freeman and Rafi Ahmed, "Restoring function in exhausted CD8 T cells during chronic viral infection", Nature, 2006, vol. 439, pages 682-687 *

Also Published As

Publication number Publication date
GB0812915D0 (en) 2008-08-20
EP2257806A1 (en) 2010-12-08
CN102084250B (zh) 2014-08-06
US8460669B2 (en) 2013-06-11
WO2009120225A1 (en) 2009-10-01
US20120213770A1 (en) 2012-08-23
AU2008353452A1 (en) 2009-10-01
EP2257806A4 (en) 2011-06-15
US7943134B2 (en) 2011-05-17
GB2458715A (en) 2009-09-30
TW201000636A (en) 2010-01-01
US20080292644A1 (en) 2008-11-27
CN102084250A (zh) 2011-06-01
JP2011519414A (ja) 2011-07-07
BRPI0822472A2 (pt) 2015-06-16

Similar Documents

Publication Publication Date Title
TWI403586B (zh) 用於偵測目標反應與治療黃病毒感染症狀之化合物及方法
US7998482B2 (en) Methods and reagents for the analysis and purification of polysaccharides
JP2025061682A (ja) 抗ｍｕｃ１６抗体及びその使用
JP6499825B2 (ja) デスモグレイン２（ｄｓｇ２）とのアデノウイルスの相互作用のための方法およびシステム
JP5520961B2 (ja) 感染症および腫瘍を処置するための方法
ES2529511T3 (es) Anticuerpos monoclonales anti-claudina 1 para la inhibición de la infección por virus de la hepatitis C
CN107531779B (zh) 血清型交叉反应性登革热中和抗体和其用途
Yang et al. Annexin 2 is a host protein binding to classical swine fever virus E2 glycoprotein and promoting viral growth in PK-15 cells
JP2010514791A (ja) 感染症および腫瘍を処置するための組成物および方法
JP2008507530A (ja) Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導
JP7535591B2 (ja) コロナウイルス感染の処置のためのＣ５ａのインヒビター
US20090048209A1 (en) Compositions comprising dc-sign blockers and methods of using dc-sign blockers for preventing or treating diseases of a mammal, including viral infections
Salampe et al. Promising marine natural products for tackling viral outbreaks: a focus on possible targets and structure-activity relationship
ES3041329T3 (en) Immunomodulatory complex and uses thereof for therapy
Cao et al. JEV NS1'protein enhances cell-to-cell viral spread by inducing the formation of tunneling nanotubes
TW202140571A (zh) 重組ace2-fc融合分子以及製造及使用彼等之方法
US9872905B2 (en) Modulation of NK cell antigen specific effector activity by modulation of CXCR6 (CD186)
EP4406973A1 (en) Antibodies and uses thereof for the treatment of infections caused by enveloped viruses
Muñiz Trabudua The potential role of Siglec-1 receptor as a therapeutic target against dendritic cell mediated dissemination of enveloped viruses
Jefferson Subcellular Barriers to Viral Infection and Gene Delivery
WO2020044285A1 (en) Antigen-binding fragment and/or aptamer for binding to an extracellular part of cd9 and therapeutic uses
Eville I will dwell in the house of the Lord. Sacred song
CN104119436A (zh) 抗丙型肝炎病毒的中和性全人单克隆抗体
JP2022523640A (ja) ウイルス組成物

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees