TWI388552B - 〔4-（3-氟-5-三氟甲基-吡啶-2-基)-哌嗪-1-基〕-〔5-甲烷磺醯基-2-（（s)-2，2，2-三氟-1-甲基-乙氧基)-苯基〕-甲酮之結晶型 - Google Patents

〔4-（3-氟-5-三氟甲基-吡啶-2-基)-哌嗪-1-基〕-〔5-甲烷磺醯基-2-（（s)-2，2，2-三氟-1-甲基-乙氧基)-苯基〕-甲酮之結晶型 Download PDF

Info

Publication number
TWI388552B
TWI388552B TW096150002A TW96150002A TWI388552B TW I388552 B TWI388552 B TW I388552B TW 096150002 A TW096150002 A TW 096150002A TW 96150002 A TW96150002 A TW 96150002A TW I388552 B TWI388552 B TW I388552B
Authority
TW
Taiwan
Prior art keywords
methyl
trifluoro
fluoro
ethoxy
phenyl
Prior art date
Application number
TW096150002A
Other languages
English (en)
Chinese (zh)
Other versions
TW200833677A (en
Inventor
Andre Bubendorf
Annette Deynet-Vucenovic
Ralph Diodone
Olaf Grassmann
Kai Lindenstruth
Emmanuel Pinard
Franziska E Rohrer
Urs Schwitter
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38988312&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TWI388552(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TW200833677A publication Critical patent/TW200833677A/zh
Application granted granted Critical
Publication of TWI388552B publication Critical patent/TWI388552B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
TW096150002A 2006-12-28 2007-12-25 〔4-（3-氟-5-三氟甲基-吡啶-2-基)-哌嗪-1-基〕-〔5-甲烷磺醯基-2-（（s)-2，2，2-三氟-1-甲基-乙氧基)-苯基〕-甲酮之結晶型 TWI388552B (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06127269 2006-12-28

Publications (2)

Publication Number Publication Date
TW200833677A TW200833677A (en) 2008-08-16
TWI388552B true TWI388552B (zh) 2013-03-11

Family

ID=38988312

Family Applications (1)

Application Number Title Priority Date Filing Date
TW096150002A TWI388552B (zh) 2006-12-28 2007-12-25 〔4-（3-氟-5-三氟甲基-吡啶-2-基)-哌嗪-1-基〕-〔5-甲烷磺醯基-2-（（s)-2，2，2-三氟-1-甲基-乙氧基)-苯基〕-甲酮之結晶型

Country Status (33)

Country Link
US (5) US20080214561A1 (enExample)
EP (1) EP2114405B1 (enExample)
JP (1) JP4799666B2 (enExample)
KR (1) KR101130146B1 (enExample)
CN (1) CN101573114A (enExample)
AR (1) AR064545A1 (enExample)
AU (1) AU2007341356B2 (enExample)
BR (1) BRPI0720829B8 (enExample)
CA (1) CA2673667A1 (enExample)
CL (1) CL2007003830A1 (enExample)
CO (1) CO6190613A2 (enExample)
CR (1) CR10846A (enExample)
CY (1) CY1116350T1 (enExample)
DK (1) DK2114405T3 (enExample)
EC (1) ECSP099471A (enExample)
ES (1) ES2535040T3 (enExample)
HR (1) HRP20150573T1 (enExample)
HU (1) HUE025032T2 (enExample)
MA (1) MA31029B1 (enExample)
MX (1) MX2009006859A (enExample)
MY (1) MY188367A (enExample)
NO (1) NO342150B1 (enExample)
NZ (1) NZ577502A (enExample)
PE (1) PE20081556A1 (enExample)
PL (1) PL2114405T3 (enExample)
PT (1) PT2114405E (enExample)
RS (1) RS53910B1 (enExample)
RU (1) RU2463295C2 (enExample)
SI (1) SI2114405T1 (enExample)
TW (1) TWI388552B (enExample)
UA (1) UA100232C2 (enExample)
WO (1) WO2008080821A1 (enExample)
ZA (1) ZA200904423B (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101573114A (zh) 2006-12-28 2009-11-04 弗·哈夫曼-拉罗切有限公司 结晶形式glyt1
JP6074142B2 (ja) * 2009-02-26 2017-02-01 タール ファーマシューティカルズ，インコーポレイテッド 医薬化合物の結晶化
KR101196354B1 (ko) * 2010-09-03 2012-11-01 서유헌 퇴행성 신경계 뇌 질환의 예방 또는 치료용 약학 조성물
EP2855462A1 (en) * 2012-05-25 2015-04-08 Basf Se Crystalline form b of 1,5-dimethyl-6-thioxo-3-(2,2,7-trifluoro-3-oxo-4-(prop-2-ynyl)-3,4-dihydro-2h-benzo[b][1,4]oxazin-6-yl)-1,3,5-triazinane-2,4-dione
US8927412B1 (en) * 2013-08-01 2015-01-06 Taiwan Semiconductor Manufacturing Company, Ltd. Multi-chip package and method of formation
MX354615B (es) * 2013-10-02 2018-03-08 Centro De Investig Y De Estudios Avanzados Del I P N Uso del propilparabeno comoagente neuroprotector en el daño neuronal inducido por status epilepticus.
KR20220125326A (ko) 2020-01-09 2022-09-14 디스크 메디슨, 인크. 적혈구형성 프로토포르피린증, x-연계된 프로토포르피린증, 또는 선천성 적혈구 조혈포르피린증을 글리신 운반 억제제로 치료하는 방법
WO2022014397A1 (ja) * 2020-07-13 2022-01-20 日本碍子株式会社 精製方法
AU2022273051A1 (en) * 2021-05-14 2023-12-07 Disc Medicine, Inc. Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors
AU2022283357A1 (en) * 2021-05-27 2023-12-07 Disc Medicine, Inc. Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with a solid form of bitopertin

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL154370A0 (en) 2003-02-10 2003-09-17 Chemagis Ltd Solid amorphous mixtures, processes for the preparation thereof and pharmaceutical compositions containing the same
UA85194C2 (ru) * 2003-08-11 2009-01-12 Ф.Хоффманн-Ля Рош Аг Пиперазины с or-замещенной фенильной группой и их применение как ингибиторов glyt 1
CN101573114A (zh) 2006-12-28 2009-11-04 弗·哈夫曼-拉罗切有限公司 结晶形式glyt1

Also Published As

Publication number Publication date
US20080214561A1 (en) 2008-09-04
PT2114405E (pt) 2015-06-02
BRPI0720829B8 (pt) 2021-05-25
AU2007341356A1 (en) 2008-07-10
US8039473B2 (en) 2011-10-18
CY1116350T1 (el) 2017-03-15
BRPI0720829A2 (pt) 2014-02-25
TW200833677A (en) 2008-08-16
AU2007341356B2 (en) 2013-08-29
UA100232C2 (uk) 2012-12-10
CN101573114A (zh) 2009-11-04
BRPI0720829B1 (pt) 2020-04-07
NZ577502A (en) 2012-02-24
KR101130146B1 (ko) 2012-03-28
CA2673667A1 (en) 2008-07-10
PL2114405T3 (pl) 2015-08-31
MX2009006859A (es) 2009-07-03
CO6190613A2 (es) 2010-08-19
SI2114405T1 (sl) 2015-06-30
CR10846A (es) 2009-08-12
RS53910B1 (sr) 2015-08-31
AR064545A1 (es) 2009-04-08
CL2007003830A1 (es) 2008-07-11
ZA200904423B (en) 2010-05-26
HUE025032T2 (en) 2016-02-29
HRP20150573T1 (xx) 2015-07-03
PE20081556A1 (es) 2008-11-28
US20130197225A1 (en) 2013-08-01
ECSP099471A (es) 2009-07-31
JP4799666B2 (ja) 2011-10-26
KR20090094166A (ko) 2009-09-03
EP2114405B1 (en) 2015-03-11
DK2114405T3 (en) 2015-04-07
RU2463295C2 (ru) 2012-10-10
US20110295007A1 (en) 2011-12-01
MA31029B1 (fr) 2009-12-01
ES2535040T3 (es) 2015-05-04
NO20092358L (no) 2009-06-22
US20120309969A1 (en) 2012-12-06
US20100311971A1 (en) 2010-12-09
JP2010514725A (ja) 2010-05-06
EP2114405A1 (en) 2009-11-11
WO2008080821A1 (en) 2008-07-10
NO342150B1 (no) 2018-04-03
MY188367A (en) 2021-12-06
RU2009124113A (ru) 2011-02-10

Similar Documents

Publication Publication Date Title
TWI388552B (zh) 〔4-（3-氟-5-三氟甲基-吡啶-2-基)-哌嗪-1-基〕-〔5-甲烷磺醯基-2-（（s)-2，2，2-三氟-1-甲基-乙氧基)-苯基〕-甲酮之結晶型
RU2460728C2 (ru) Соль моносульфат 2-хлор-4-[1-(4-фторфенил)-2,5-диметил-1н-имидазол-4-илэтинил]-пиридина и ее кристаллическая форма, содержащая их фармацевтическая композиция и способ получения
CN114174284A (zh) 6-(环丙烷甲酰胺基)-4-((2-甲氧基-3-(1-甲基-1H-1,2,4-三唑-3-基)苯基)氨基)-N-(甲基-d3)哒嗪-3-甲酰胺的结晶盐形式
CN114026088A (zh) Jak2抑制剂的结晶形式
CA3165764A1 (en) Crystalline forms of voxelotor, and processes for the preparation thereof
HK1136207A (en) Crystalline forms glyt1
TW202527943A (zh) 2-(4-(2-(7,8-二甲基-[1,2,4]三唑[1,5-a]吡啶-6-基)-3-異丙基-1h-吲哚-5-基)哌啶-1-基)乙醯胺鹽及其結晶形式
HK40079890A (en) Compositions and methods related to picolinylpiperidine 5-ht1f agonists
HK40079891A (en) Compositions and methods related to pyridinoylpiperidine 5-ht1f agonists
WO2024023796A1 (en) Polymorphs, co-crystals and solvates of fruquintinib, processes for the preparation and use thereof
WO2025149547A1 (en) New solid forms of n-[(1s,2e)-1-cyclopropyl-3-(methanesulfonyl)prop-2-en-1-yl]-2- (1,1-difluoroethyl)-4- phenoxypyrimidine-5-carboxamide
BR112021013035A2 (pt) Complexo molecular de binimetinibe, processo para preparar solvato de dmso de binimetinibe, complexo molecular, processo para preparar um complexo molecular cristalino de binimetinibe e ácido cítrico, composição farmacêutica, método para inibir a atividade de mek, e, método para o tratamento de um distúrbio hiperproliferativo.
BRPI0720954B1 (pt) Forma cristalina do sal de monossulfato de um antagonista de receptor mglur5, seu uso, processo de preparação do mesmo e composição farmacêutica que o compreende