TWI325323B - Cross-linked glycopeptide-cephalosporin antibiotics - Google Patents

Cross-linked glycopeptide-cephalosporin antibiotics Download PDF

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Publication number
TWI325323B
TWI325323B TW092114010A TW92114010A TWI325323B TW I325323 B TWI325323 B TW I325323B TW 092114010 A TW092114010 A TW 092114010A TW 92114010 A TW92114010 A TW 92114010A TW I325323 B TWI325323 B TW I325323B
Authority
TW
Taiwan
Prior art keywords
group
alkyl
hydrogen
independently selected
compound
Prior art date
Application number
TW092114010A
Other languages
English (en)
Chinese (zh)
Other versions
TW200307556A (en
Inventor
Marquess Daniel
S Linsell Martin
Derek Turner S
G Trapp Sean
D Long Daniel
Fatheree Paul
Original Assignee
Theravance Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theravance Inc filed Critical Theravance Inc
Publication of TW200307556A publication Critical patent/TW200307556A/zh
Application granted granted Critical
Publication of TWI325323B publication Critical patent/TWI325323B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure
    • C07K9/008—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure directly attached to a hetero atom of the saccharide radical, e.g. actaplanin, avoparcin, ristomycin, vancomycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)
TW092114010A 2002-05-24 2003-05-23 Cross-linked glycopeptide-cephalosporin antibiotics TWI325323B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US38327402P 2002-05-24 2002-05-24

Publications (2)

Publication Number Publication Date
TW200307556A TW200307556A (en) 2003-12-16
TWI325323B true TWI325323B (en) 2010-06-01

Family

ID=29584538

Family Applications (1)

Application Number Title Priority Date Filing Date
TW092114010A TWI325323B (en) 2002-05-24 2003-05-23 Cross-linked glycopeptide-cephalosporin antibiotics

Country Status (8)

Country Link
US (4) US6878686B2 (enExample)
EP (1) EP1507796B1 (enExample)
JP (2) JP4347799B2 (enExample)
AT (1) ATE556088T1 (enExample)
AU (1) AU2003231833A1 (enExample)
ES (1) ES2384707T3 (enExample)
TW (1) TWI325323B (enExample)
WO (1) WO2003099858A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2201825T3 (es) * 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
WO2003099858A1 (en) * 2002-05-24 2003-12-04 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
ATE450540T1 (de) 2003-05-23 2009-12-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
ATE388153T1 (de) * 2003-07-11 2008-03-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
NO20073821L (no) * 2006-07-21 2008-01-22 Akzo Nobel Chemicals Int Bv Podede kopolymerer med lav molekylvekt
JP2012528119A (ja) * 2009-05-29 2012-11-12 コヴァルクス・アーゲー 分子間相互作用分析用の架橋試薬
US20140171357A1 (en) * 2011-03-24 2014-06-19 Seachaid Pharmaceuticals, Inc. Vancomycin derivatives
HK1200096A1 (en) 2011-09-09 2015-07-31 Merck Sharp & Dohme Corp. Methods for treating intrapulmonary infections
US8809314B1 (en) 2012-09-07 2014-08-19 Cubist Pharmacueticals, Inc. Cephalosporin compound
US8476425B1 (en) 2012-09-27 2013-07-02 Cubist Pharmaceuticals, Inc. Tazobactam arginine compositions
ES2634019T3 (es) 2013-03-13 2017-09-26 Theravance Biopharma Antibiotics Ip, Llc Forma cristalina de una sal de trietilamina del ácido tiazolilacético sustituido
WO2014152332A1 (en) 2013-03-15 2014-09-25 Melinta Therapeutics, Inc. Methods of treating infections in overweight and obese patients using antibiotics
US9872906B2 (en) 2013-03-15 2018-01-23 Merck Sharp & Dohme Corp. Ceftolozane antibiotic compositions
US20140274994A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Stabilizing ceftolozane
US20140274993A1 (en) 2013-03-15 2014-09-18 Cubist Pharmaceuticals, Inc. Ceftolozane-tazobactam pharmaceutical compositions
US10376496B2 (en) 2013-09-09 2019-08-13 Merck, Sharp & Dohme Corp. Treating infections with ceftolozane/tazobactam in subjects having impaired renal function
US8906898B1 (en) 2013-09-27 2014-12-09 Calixa Therapeutics, Inc. Solid forms of ceftolozane
WO2023230205A1 (en) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Mek inhibitors and uses thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7A (en) 1836-08-10 Thomas Blanchard Machine for boring holes and cutting lanyard-scores in deadeyes
US5693A (en) 1848-08-01 Window-catch
US947926A (en) * 1908-09-15 1910-02-01 William C Meyer Expansion-reamer.
US4341775A (en) * 1978-09-11 1982-07-27 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds
GB2033377B (en) 1978-09-11 1983-05-05 Fujisawa Pharmaceuticalco Ltd Cephem compounds and processes for preparation thereof
US4220761A (en) * 1978-09-12 1980-09-02 Fujisawa Pharmaceutical Co., Ltd. 7-[Substituted oximinoacetamido]-3-[hydroxy alkyltetrazolo]cephalosporin derivatives
JPS6041682A (ja) 1983-08-16 1985-03-05 Meiji Seika Kaisha Ltd 新規セフアロスポリン化合物及びその製造法
US4921851A (en) * 1986-06-09 1990-05-01 Takeda Chemical Industries, Ltd. Cephem compounds, their production and use
AU1630988A (en) * 1987-05-30 1988-12-01 Kyoto Pharmaceutical Industries, Ltd. Cephalosporin compound and pharmaceutical composition thereof
US5693791A (en) * 1995-04-11 1997-12-02 Truett; William L. Antibiotics and process for preparation
WO1999042476A1 (en) 1998-02-20 1999-08-26 Advanced Medicine, Inc. Novel antibacterial agents
US6437119B1 (en) * 1998-05-07 2002-08-20 William Lawrence Truett Compounds formed from two or three antibiotics and their processes of preparation
EP1085846A2 (en) 1998-06-08 2001-03-28 Advanced Medicine, Inc. Multibinding inhibitors of microsomal triglyceride transferase protein
US7208572B2 (en) * 1998-08-21 2007-04-24 Albany Medical College Leptin-related peptides
ES2201825T3 (es) 1998-12-23 2004-03-16 Theravance, Inc. Derivados del glicopeptidos y composiciones farmaceuticas que los contienen.
WO2001057071A2 (en) * 2000-02-04 2001-08-09 Advanced Medicine, Inc. Glycopeptide derivatives having antibiotic activity
UA75083C2 (uk) 2000-06-22 2006-03-15 Тераванс, Інк. Похідні глікопептидфосфонатів
US20030008812A1 (en) * 2001-02-02 2003-01-09 Christensen Burton G. Glycopeptide derivatives
TWI335332B (en) 2001-10-12 2011-01-01 Theravance Inc Cross-linked vancomycin-cephalosporin antibiotics
WO2003099858A1 (en) * 2002-05-24 2003-12-04 Theravance, Inc. Cross-linked glycopeptide-cephalosporin antibiotics
ATE450540T1 (de) * 2003-05-23 2009-12-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika
US7127856B2 (en) * 2003-06-06 2006-10-31 Hans T. Hagen, Jr. Insulated stud panel and method of making such
ATE388153T1 (de) 2003-07-11 2008-03-15 Theravance Inc Quervernetzte glycopeptid-cephalosporin- antibiotika

Also Published As

Publication number Publication date
JP2009256358A (ja) 2009-11-05
JP2006503805A (ja) 2006-02-02
ATE556088T1 (de) 2012-05-15
US8084417B2 (en) 2011-12-27
JP4347799B2 (ja) 2009-10-21
US20050209132A1 (en) 2005-09-22
US20040033939A1 (en) 2004-02-19
US20060025332A1 (en) 2006-02-02
WO2003099858A1 (en) 2003-12-04
TW200307556A (en) 2003-12-16
ES2384707T3 (es) 2012-07-11
AU2003231833A1 (en) 2003-12-12
US7405199B2 (en) 2008-07-29
EP1507796A1 (en) 2005-02-23
US20090137460A1 (en) 2009-05-28
US6878686B2 (en) 2005-04-12
US6995138B2 (en) 2006-02-07
EP1507796B1 (en) 2012-05-02

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