TWI288640B - Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies - Google Patents
Agents which regulate, inhibit, or modulate the activity and/or expression of connective tissue growth factor (CTGF) as a unique means to both lower intraocular pressure and treat glaucomatous retinopathies/optic neuropathies Download PDFInfo
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- TWI288640B TWI288640B TW092109994A TW92109994A TWI288640B TW I288640 B TWI288640 B TW I288640B TW 092109994 A TW092109994 A TW 092109994A TW 92109994 A TW92109994 A TW 92109994A TW I288640 B TWI288640 B TW I288640B
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- ctgf
- glaucoma
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- intraocular pressure
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| KR20040104566A (ko) * | 2002-04-30 | 2004-12-10 | 알콘, 인코퍼레이티드 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ｃｔｇｆ)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
| TW200526224A (en) * | 2003-12-22 | 2005-08-16 | Alcon Inc | Short form c-Maf transcription factor antagonists for treatment of glaucoma |
| ATE400297T1 (de) | 2004-02-11 | 2008-07-15 | Fibrogen Inc | Ctgf als zielmolekül in der behandlung von mikroalbuminurie in patienten mit diabetischer nephropathie |
| AU2005244154C1 (en) | 2004-04-28 | 2010-07-01 | Fibrogen, Inc. | Treatments for pancreatic cancer |
| WO2006021817A2 (en) | 2004-08-23 | 2006-03-02 | Sylentis S.A.U. | Treatment of eye disorders characterized by an elevated introacular pressure by sirnas |
| US7803824B2 (en) * | 2004-10-29 | 2010-09-28 | Alcon, Inc. | Use of inhibitors of Jun N-terminal kinases to treat glaucoma |
| TWI386225B (zh) * | 2004-12-23 | 2013-02-21 | Alcon Inc | 用於治療眼睛病症的結締組織生長因子（ＣＴＧＦ）ＲＮＡ干擾（ＲＮＡｉ）抑制技術 |
| US20060275797A1 (en) * | 2005-03-21 | 2006-12-07 | Alcon Manufacturing, Ltd. | Use of agents which inhibit connective tissue growth factor (CTGF) binding and signaling via the TrkA/p75NTR receptor complex for the prevention and treatment of CTGF-mediated ocular disorders |
| EP2002841A4 (en) | 2006-03-23 | 2009-04-15 | Senju Pharma Co | OPHTHALMIC COMPOSITION WITH XANTHANGUMMI AND GLUCOSE |
| CN101505744A (zh) * | 2006-07-25 | 2009-08-12 | 爱尔康研究有限公司 | 用于预防和治疗眼部病症的内皮分化基因亚家庭3（edg-3，s1p3）受体的拮抗剂 |
| US20080057072A1 (en) * | 2006-08-31 | 2008-03-06 | Alcon Manufacturing, Ltd. | Antagonists of ci-m6p/igf2r for prevention and treatment of ctgf-mediated ocular disorders |
| US20090202524A1 (en) * | 2007-10-31 | 2009-08-13 | Alcon Research, Ltd. | Pai-1 expression and activity inhibitors for the treatment of ocular disorders |
| US20100158897A1 (en) * | 2006-10-31 | 2010-06-24 | Alcon Research, Ltd. | Pai-1 modulators for the treatment of ocular disorders |
| AU2007313684A1 (en) * | 2006-10-31 | 2008-05-08 | Alcon Research, Ltd. | PAI-1 binding modulators for the treatment of ocular disorders |
| US7807629B1 (en) | 2007-06-05 | 2010-10-05 | Alcon Research, Ltd. | Use of bradykinin and related B2R agonists to treat ocular hypertension and glaucoma |
| US8173668B1 (en) | 2007-06-05 | 2012-05-08 | Alcon Research, Ltd. | Use of non-peptidic bradykinin receptor agonists to treat ocular hypertension and glaucoma |
| RU2392960C1 (ru) * | 2008-09-26 | 2010-06-27 | Учреждение Российской академии медицинских наук Научный центр реконструктивной и восстановительной хирургии Сибирского отделения РАМН (НЦРВХ СО РАМН) | Способ коррекции плотности соединительной ткани |
| RU2411033C1 (ru) * | 2009-05-12 | 2011-02-10 | Государственное образовательное учреждение высшего профессионального образования "Владивостокский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" (ГОУ ВПО ВГМУ Росздрава) | Способ лечения глаукомной оптической нейропатии в пожилом и старом возрасте |
| CN102666587A (zh) | 2009-07-02 | 2012-09-12 | 菲布罗根有限公司 | 用于治疗肌营养不良的方法 |
| WO2011056234A1 (en) | 2009-11-06 | 2011-05-12 | Fibrogen, Inc. | Treatment for radiation-induced disorders |
| EA025415B1 (ru) | 2010-01-11 | 2016-12-30 | Инотек Фармасьютикалз Корпорейшн | Комбинация, набор и способ снижения внутриглазного давления |
| EP2569325A4 (en) | 2010-03-26 | 2013-10-09 | Inotek Pharmaceuticals Corp | METHOD FOR REDUCING INNER EYE PRESSURE IN HUMANS USING N6-CYCLOPENTYLADENOSINE (CPA), CPA DERIVATIVES OR PRODRUGS THEREOF |
| RU2424796C1 (ru) * | 2010-05-12 | 2011-07-27 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Способ лечения токсической оптической нейропатии, вызванной длительным приемом кодеинсодержащих лекарственных средств |
| TW201210584A (en) | 2010-08-18 | 2012-03-16 | Alcon Res Ltd | Bradykinin receptor agonists and uses thereof to treat ocular hypertension and glaucoma |
| US20140134181A1 (en) | 2010-11-05 | 2014-05-15 | Kenneth E. Lipson | Treatment Method For Lung Remodeling Diseases |
| US9278991B2 (en) | 2012-01-26 | 2016-03-08 | Inotek Pharmaceuticals Corporation | Anhydrous polymorphs of [(2R,3S,4R,5R)-5-(6-(cyclopentylamino)-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)} methyl nitrate and processes of preparation thereof |
| IN2015DN02699A (enExample) | 2012-09-05 | 2015-09-04 | Sylentis Sau | |
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| RU2128486C1 (ru) * | 1997-04-04 | 1999-04-10 | Центр по химии лекарственных средств | Антиглаукоматозное средство |
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| KR20040104566A (ko) | 2002-04-30 | 2004-12-10 | 알콘, 인코퍼레이티드 | 안압 저하 및 녹내장성 망막병증/시신경병증 치료를 위한특유의 수단으로서의 결합 조직 성장 인자 (ｃｔｇｆ)의활성 및/또는 발현 조절, 저해, 또는 변조제 |
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| JP2010280723A (ja) | 2010-12-16 |
| CA2482789A1 (en) | 2003-11-13 |
| EP2221054A1 (en) | 2010-08-25 |
| WO2003092584A2 (en) | 2003-11-13 |
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| US20050234075A1 (en) | 2005-10-20 |
| JP2005523928A (ja) | 2005-08-11 |
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| CN1650001A (zh) | 2005-08-03 |
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