TWI280242B - Pharmaceutical compounds - Google Patents

Pharmaceutical compounds Download PDF

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Publication number
TWI280242B
TWI280242B TW089125715A TW89125715A TWI280242B TW I280242 B TWI280242 B TW I280242B TW 089125715 A TW089125715 A TW 089125715A TW 89125715 A TW89125715 A TW 89125715A TW I280242 B TWI280242 B TW I280242B
Authority
TW
Taiwan
Prior art keywords
benzo
ethyl
carboxylic acid
morphine
dimethylamino
Prior art date
Application number
TW089125715A
Other languages
English (en)
Chinese (zh)
Inventor
John Milton
Nigel Vicker
Adrian John Folkes
Shouming Wang
William Alexander Denny
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Application granted granted Critical
Publication of TWI280242B publication Critical patent/TWI280242B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW089125715A 1999-12-02 2000-12-02 Pharmaceutical compounds TWI280242B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9928542.1A GB9928542D0 (en) 1999-12-02 1999-12-02 Pharmaceutical compounds

Publications (1)

Publication Number Publication Date
TWI280242B true TWI280242B (en) 2007-05-01

Family

ID=10865607

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089125715A TWI280242B (en) 1999-12-02 2000-12-02 Pharmaceutical compounds

Country Status (16)

Country Link
EP (1) EP1240148A1 (pt)
JP (1) JP2003518103A (pt)
KR (1) KR100767613B1 (pt)
CN (1) CN1304380C (pt)
AU (1) AU784397B2 (pt)
BR (1) BR0016093A (pt)
CA (1) CA2392873A1 (pt)
GB (2) GB9928542D0 (pt)
HK (1) HK1046133B (pt)
HU (1) HUP0300392A3 (pt)
MX (1) MXPA02005476A (pt)
MY (1) MY136029A (pt)
PL (1) PL356482A1 (pt)
TW (1) TWI280242B (pt)
WO (1) WO2001046157A1 (pt)
ZA (1) ZA200204296B (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2433071A (en) * 2005-12-05 2007-06-13 Kontrakt Technology Ltd Organic acids comprising planar conjugated heterocyclic molecular system, & photoelectric layer thereof with rodlike supramolecules for use in solar cell
CN102898388B (zh) * 2012-09-26 2014-12-03 浙江工业大学 一种合成取代苯并[α]吩嗪类化合物的方法
CN103360329B (zh) * 2013-07-18 2015-11-18 中国科学院南海海洋研究所 一类吩嗪化合物及其在制备抗肿瘤药物中的应用
CN106554321B (zh) * 2015-09-25 2019-05-28 陆源 一种吩嗪类物质、其制备方法及其应用
CN113461623A (zh) * 2021-07-14 2021-10-01 长江大学 一种抗病毒化合物及其制备方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU691787B2 (en) * 1992-05-28 1998-05-28 Xenova Limited Treatment of cancers
US5696131A (en) * 1993-01-22 1997-12-09 Xenova Limited Treatment of cancers
AU725938B2 (en) * 1996-09-23 2000-10-26 Rutgers, The State University Of New Jersey Substituted heterocycles as anti-tumor agents
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors

Also Published As

Publication number Publication date
CA2392873A1 (en) 2001-06-28
WO2001046157A1 (en) 2001-06-28
CN1304380C (zh) 2007-03-14
CN1433406A (zh) 2003-07-30
HK1046133A1 (en) 2002-12-27
AU1718401A (en) 2001-07-03
BR0016093A (pt) 2002-08-20
GB2373499A (en) 2002-09-25
HUP0300392A3 (en) 2003-09-29
GB0215275D0 (en) 2002-08-14
HK1046133B (zh) 2005-04-15
HUP0300392A2 (hu) 2003-07-28
MY136029A (en) 2008-07-31
AU784397B2 (en) 2006-03-23
GB9928542D0 (en) 2000-02-02
JP2003518103A (ja) 2003-06-03
MXPA02005476A (es) 2003-09-22
GB2373499B (en) 2004-11-17
KR100767613B1 (ko) 2007-10-19
ZA200204296B (en) 2003-05-29
KR20020070305A (ko) 2002-09-05
PL356482A1 (en) 2004-06-28
EP1240148A1 (en) 2002-09-18

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Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees