GB0215275D0 - Benzo(a)phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase I and II - Google Patents

Benzo(a)phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase I and II

Info

Publication number
GB0215275D0
GB0215275D0 GBGB0215275.9A GB0215275A GB0215275D0 GB 0215275 D0 GB0215275 D0 GB 0215275D0 GB 0215275 A GB0215275 A GB 0215275A GB 0215275 D0 GB0215275 D0 GB 0215275D0
Authority
GB
United Kingdom
Prior art keywords
topomerase
phenazin
benzo
carboxamide derivatives
inhibitors
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GBGB0215275.9A
Other versions
GB2373499A (en
GB2373499B (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Xenova Ltd
Original Assignee
Xenova Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Xenova Ltd filed Critical Xenova Ltd
Publication of GB0215275D0 publication Critical patent/GB0215275D0/en
Publication of GB2373499A publication Critical patent/GB2373499A/en
Application granted granted Critical
Publication of GB2373499B publication Critical patent/GB2373499B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/46—Phenazines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
GB0215275A 1999-12-02 2000-12-01 Pharmaceutical compounds Expired - Fee Related GB2373499B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9928542.1A GB9928542D0 (en) 1999-12-02 1999-12-02 Pharmaceutical compounds
PCT/GB2000/004609 WO2001046157A1 (en) 1999-12-02 2000-12-01 Benzo[a]phenazin-11-carboxamide derivatives and their use as joint inhibitors of topomerase i and ii

Publications (3)

Publication Number Publication Date
GB0215275D0 true GB0215275D0 (en) 2002-08-14
GB2373499A GB2373499A (en) 2002-09-25
GB2373499B GB2373499B (en) 2004-11-17

Family

ID=10865607

Family Applications (2)

Application Number Title Priority Date Filing Date
GBGB9928542.1A Ceased GB9928542D0 (en) 1999-12-02 1999-12-02 Pharmaceutical compounds
GB0215275A Expired - Fee Related GB2373499B (en) 1999-12-02 2000-12-01 Pharmaceutical compounds

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GBGB9928542.1A Ceased GB9928542D0 (en) 1999-12-02 1999-12-02 Pharmaceutical compounds

Country Status (16)

Country Link
EP (1) EP1240148A1 (en)
JP (1) JP2003518103A (en)
KR (1) KR100767613B1 (en)
CN (1) CN1304380C (en)
AU (1) AU784397B2 (en)
BR (1) BR0016093A (en)
CA (1) CA2392873A1 (en)
GB (2) GB9928542D0 (en)
HK (1) HK1046133B (en)
HU (1) HUP0300392A3 (en)
MX (1) MXPA02005476A (en)
MY (1) MY136029A (en)
PL (1) PL356482A1 (en)
TW (1) TWI280242B (en)
WO (1) WO2001046157A1 (en)
ZA (1) ZA200204296B (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2433071A (en) * 2005-12-05 2007-06-13 Kontrakt Technology Ltd Organic acids comprising planar conjugated heterocyclic molecular system, & photoelectric layer thereof with rodlike supramolecules for use in solar cell
CN102898388B (en) * 2012-09-26 2014-12-03 浙江工业大学 Method for synthesizing substituted benzo[alpha]phenazine compound
CN103360329B (en) * 2013-07-18 2015-11-18 中国科学院南海海洋研究所 One class compound phenazine and preparing the application in antitumor drug
CN106554321B (en) * 2015-09-25 2019-05-28 陆源 A kind of azophenlyene substance, preparation method and its application
CN113461623A (en) * 2021-07-14 2021-10-01 长江大学 Antiviral compound and preparation method and application thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696131A (en) * 1993-01-22 1997-12-09 Xenova Limited Treatment of cancers
DE69329336D1 (en) * 1992-05-28 2000-10-05 Xenova Ltd ACRIDIN CARBOXAMIDE FOR TREATING CANCER
PL332416A1 (en) * 1996-09-23 1999-09-13 Rutgers Substituted heterocyclic compounds as anticarcinogenic agents
WO1998045272A1 (en) * 1997-04-07 1998-10-15 Latrobe University Topoisomerase inhibitors

Also Published As

Publication number Publication date
ZA200204296B (en) 2003-05-29
KR100767613B1 (en) 2007-10-19
TWI280242B (en) 2007-05-01
WO2001046157A1 (en) 2001-06-28
EP1240148A1 (en) 2002-09-18
HK1046133B (en) 2005-04-15
JP2003518103A (en) 2003-06-03
MXPA02005476A (en) 2003-09-22
KR20020070305A (en) 2002-09-05
CA2392873A1 (en) 2001-06-28
CN1433406A (en) 2003-07-30
HUP0300392A3 (en) 2003-09-29
MY136029A (en) 2008-07-31
CN1304380C (en) 2007-03-14
GB9928542D0 (en) 2000-02-02
HUP0300392A2 (en) 2003-07-28
BR0016093A (en) 2002-08-20
GB2373499A (en) 2002-09-25
AU1718401A (en) 2001-07-03
HK1046133A1 (en) 2002-12-27
AU784397B2 (en) 2006-03-23
GB2373499B (en) 2004-11-17
PL356482A1 (en) 2004-06-28

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