1277422 九、發明說明： 【發明所屬之技術領域】 本發明係關於一種新穎之含薑黃組成物。詳言之，係 ·、 關於以薑黃與鯊烯或三十碳烷之混合物為主要成分之新顆 、 含薑黃組成物，及再混合胡椒驗及/或食用纖維之新顆含蔓 黃組成物。本發明，係根據新穎含薑黃組成物之肝功能保 護及改善功能之有用性而構成。1277422 IX. Description of the invention: [Technical field to which the invention pertains] The present invention relates to a novel turmeric-containing composition. In particular, it is a new, turmeric-containing composition containing turmeric and a mixture of squalene or triaconane as a main component, and a new vine-like composition containing a mixture of pepper and/or edible fiber. . The present invention is constituted by the usefulness of the liver function protection and the improvement function of the novel turmeric-containing composition.
【先前技術】 I 關於以往之肝功能改善劑，係使用胺基酸製劑、麵胱 甘肽（glutathione )、肝臟水解物、中藥等，但其作用緩 和而效果優異者甚少。至於自植物之組成物，雖稱田七人 參、奶薊（Milk thistle)、薑黃等具有肝功能改善效果，但 其效果仍稱不上充分。 另一方面，鯊烯及三十碳烷為深海鯊魚之肝油成分， 雖稱具有細胞活化作用、免疫強化作用、抗氧化作用、止 痛作用、殺菌作用、滲透作用等效果，但未見其有關於肝 _ 功能改善效果之報告。 又’雖已揭示含有由薑黃抽提之薑黃油溶性成分之食 用油脂（專利文獻丨），但未見含有以薑黃素、鯊烯或三十 碳烷作為有效成分、而顯示肝功能改善效果之組成物之報 告。 胡椒驗為胡椒之辣味成分，有報告指出胡椒鹼能夠提 升薑黃所含薑黃素之生物學有效性（非專利文獻1}。同時 5 1277422 配合薑黃素與胡椒鹼作為有效成分，以作為發炎性腸疾病 患者之預防、治療劑亦已被揭示（專利文獻1)。然而，未 見含有量黃素、鯊烯或三十碳烧、胡椒驗等3種成分之組 成物之報告。 專利文獻1 :特開2001 - 86931 專利文獻2 :特開2003 - 55202 非專利文獻 1 ·· Guido Shoba a/. Planta Mediea 64(1998):353-356 【發明内容】 量黃’含有薑黃素及精油成分等，自古即作為一種中 藥而作為肝炎、腎臟炎、膽道炎、膽結石及胃炎等之治療 藥或保健藥等使用。然而，由於薑黃之有效成分薑黃素與 精油成分為疏水性而吸收性差，故其肝功能改善效果與其 他來自植物之組成物相同無法稱得上足夠。本發明之課 題，在於提供新穎之含薑黃組成物，藉以提供能夠充分發 揮肝臟保護功能及改善功能之組成物。 本發明人為解決上述課題，探討將薑黃與鯊烯或三十 石反烷配合之結果，發現新穎組成物具有顯著肝功能保護及 $善效果，且發現較單獨使用此等更能相乘性地增大肝功 能保護及改善效果，而完成本發明。 亦即，本發明由以下構成： 1 · 一種含薑黃組成物，其特徵為將薑黃與鯊烯或三十 厌烷配σ，且畺黃與鯊烯或三十碳烷之配合比例為2 : 8〜 1277422 2 ·如上述1之含薑黃組成物，其中，薑黃為乾燥粉碎 物、或有機溶劑萃取物或其乾燥物。 3 ·如上述2之含薑黃組成物，其中，有機溶劑萃取物 中含有薑黃成分之薑黃素。 4·如上述1〜3任一項之含薑黃組成物，其中，薑黃 為 Cwcwma /μ別（秋薑黃）、(春薑黃）、[Prior Art] In the conventional liver function improving agent, an amino acid preparation, a glutathione, a liver hydrolyzate, a Chinese medicine, or the like is used, but the effect is alleviated and the effect is excellent. As for the composition of the plant, although the seven ginseng, milk thistle, turmeric and the like have liver function improvement effects, the effect is still not sufficient. On the other hand, squalene and triacontane are the liver oil components of deep-sea sharks, although they have effects such as cell activation, immune enhancement, anti-oxidation, analgesic, bactericidal, and osmotic effects, but they are not relevant. Liver _ function improvement report. Further, although edible fats and oils containing a ginger butter-soluble component extracted from turmeric have been disclosed (Patent Document 丨), it has not been shown to contain curcumin, squalene or triacontan as an active ingredient, and the liver function is improved. Report of the composition. Pepper is a spicy ingredient in pepper. It has been reported that piperine can improve the biological effectiveness of curcumin contained in turmeric (Non-Patent Document 1). At the same time, 5 1277422 is combined with curcumin and piperine as an active ingredient to be inflammatory. A prophylactic or therapeutic agent for patients with intestinal diseases has also been disclosed (Patent Document 1). However, no report has been made of a composition containing three components such as flavin, squalene, or tricarbone or pepper. Patent Document 1 JP-A-2001-86931 Patent Document 2: JP-A-2003-55202 Non-Patent Document 1 · Guido Shoba a/. Planta Mediea 64 (1998): 353-356 [Summary of the Invention] The amount of yellow contains curcumin and essential oil components. It has been used as a traditional Chinese medicine since ancient times as a therapeutic or health care medicine for hepatitis, nephritis, biliary tract, gallstones and gastritis, etc. However, since the active constituents of turmeric and curcumin are hydrophobic and poorly absorbable, Therefore, the liver function improvement effect is not sufficient to be the same as other plant-derived compositions. The object of the present invention is to provide a novel turmeric-containing composition, thereby providing sufficient The present inventors have solved the above problems and discussed the results of combining turmeric with squalene or 30 stone anti-alkane, and found that the novel composition has significant liver function protection and good effect, and found The present invention is completed by multiplying the liver function protection and the improvement effect more versatilely. That is, the present invention consists of the following: 1 · A turmeric-containing composition characterized by turmeric and squalene Or thirty anaerobics with σ, and the ratio of yttrium to squalene or tridecane is 2: 8~ 1277422 2 · The turmeric-containing composition according to the above 1, wherein turmeric is a dry pulverized material or an organic solvent The turmeric-containing composition containing the turmeric component, wherein the turmeric composition of the above-mentioned 1 to 3, wherein Turmeric is Cwcwma /μ (autumn turmeric), (spring turmeric),
Curcuma zedoaria(遂藏術）、氣 Curcuma xanthorrhiza(黃板 薑黃）。 5 ·如上述1〜4任一項之含薑黃組成物，其中，鯊烯 為深海魚類所含之不飽和烴。 6 ·如上述5之含薑黃組成物，其中，鯊烯為存在於鯊 魚類肝油中之不飽和烴。 7·如上述1〜4任一項之含薑黃組成物，其中，三十 碳烧為將深海魚類所含之不飽和烴、或存在於鯊魚類肝油 中之不飽和烴，還原而成之飽和烴。 8·如上述1〜4任一項之含薑黃組成物，其中，三十 碳烧為以香葉草丙酮及乙炔化合物為原料合成所得之合成 三十碳烷。 9·如上述1〜8任一項之含薑黃組成物，其中，進一 步配合含胡椒驗原料作為有效成分。 1 〇 ·如上述9之含薑黃組成物，其中，含胡椒鹼原料 為胡椒及/或蓽撥。 11.如上述1〜10任一項之含薑黃組成物，其中，進 1277422 一步配合食用纖維作為有效成分。 12 ·如上述11之含薑黃組成物，其中，食用纖維為水 溶性食用纖維。 13 ·如上述i〜12任一項之含薑黃組成物，其係為了 肝功能之保護作用或改善作用而被攝取。 14·如上述丨〜13任一項之含薑黃組成物，其係為了 預防及/或治療肝功能障礙而被攝取。 15· 一種食品，其含有如上述1〜14任一項之含薑黃 組成物。 16·種製劑，其係以含有如上述1〜14任一項之含 量黃組成物之膠囊劑、錠劑、或糖漿劑之任一劑型所製成。 本發明之新穎含薑黃組成物，藉由將薑黃與鯊烯或三 十&烧配合’而為具有優異肝功能保護及改善效果者，而 由:亥組成物構成之食品或輔助製劑，亦顯現優異之肝功能 效果。本發明之新穎含薑黃組成物之肝功能保 穎因再配合胡椒鹼而更增強。且本發明之新 、3量頁組成物由於完全無副作用，故實用性極高。 L 1抛万式】 本發明所使用之薑黃’可為採集之薑黃之乾燥粉碎物、 ::為有機溶劑萃取物或其乾燥物。有機溶劑，可=使 可依二墓黃之有機溶劑萃取物本身為周知者， J依周知之方法調製。乾燥 然蒸發乾燥或加熱乾燥等4處==亦可利用自 八恩理方法，只要能夠有效回 8 1277422 收薑黃之成分薑黃素者即可，無特別限定。 q本發明所使用薑黃種類，可舉例> c⑽㈣，—秋 j 黃）、(春薑黃）、Cwr⑶π如(蓬 莪術）、或CwcwwaA〇rr/^a(黃根薑黃）。其中以 /⑽抑（秋薑黃）為特佳。 成烯為非環狀三秘之一種，係富含於黨魚類肝油之益 色油。當吸收氧則變成黏性油。W可直接使用富含肝油 天’物或可使用精製之鯊稀。鯊豨亦可使用深海魚 類所含之不飽和烴。其中以使用存在於黨、魚類肝油中之不 飽和烴為特佳。 三十碳烷，係鯊烯之代謝產物，可將深海魚類所含有 =不飽和烴、或存在於t魚類肝油中之不飽和烴還原而製 得。又，三十碳烷亦可為以香葉草丙酮及乙炔化合物為原 料合成所得之合成三十碳烷。 胡椒鹼，已知為胡椒之辣味成分，其作用為提高薑黃 成分之薑黃素之生物體利用率。 含有胡椒鹼之含胡椒鹼原料，可使用胡椒、蓽撥⑽ long pepper)、或其組合等香辛料，其中以使用蓽撥較佳。 蓽撥，為經常使用於沖繩料理之香辛料，又稱琵哈茲、灰 華棘、琵華棘等（以上均為蓽撥之日本俗名）。其產地，在 日本國：為沖，尤其以八重山地區為主，作為商品而市 售者甚多。本發明亦可購入此等商品使用。或者，亦可將 尸/⑽抑所（蓽撥）或Ρφπ reiro/rac/wm(擬蓽撥）之種子乾 燥私碎作為蓽撥使用，而將戶(per "/grwm(胡椒）之種子 1277422 乾燥、粉碎作為胡椒使用。 艮用、截維，思指通常無法被人體消化酵素分解之成分， 其中有海藻所含之水溶性食用纖維與榖類等所含之非水溶 性食用纖維。於本發明，以使用能夠抑制糖、脂肪、膽固 醇等之吸收之水溶性食用纖維為佳，尤其以藻酸或藻酸鹽 (鈉鹽、鉀鹽等）、難消化性糊精等較適，但於本發明只要 為含有食用纖維者均可使用。 如上述之薑黃與t烯及/或三十碳烷，及胡椒鹼及/或 食用纖維，可藉由常法之製劑化技術適當配合。 本發明之含薑黃組成物中，薑黃與鯊烯或三十碳烷之 配合比例為2 : 8〜5 : 5，而以3 : 7〜4 : 6為佳，尤以3.5 : 6.5為更佳。此配合比例，可考慮薑黃之薑黃素含量而適 當決定。 本發明之含薑黃組成物進一步含有含胡椒鹼原料時， 量頁對含胡椒鹼原料之配合比例為1 〇 : 1〜1 : 1，而以5 : 1〜2 : 1為佳，尤以3 : i為更佳。此配合比例，可考慮薑 汽之量黃素含量及含胡椒鹼原料之胡椒鹼含量而適當決 定。 本發明之含量黃組成物進一步含有食用纖維時，食用 纖維配合量較難統一規定，但可配合成食用纖維之每曰攝 取ϊ ( 2g〜30g，以4g〜15g為佳，尤以為更佳）。此 配合量’可考慮組成物中之薑黃含量與食用纖維種類等而 適¥决疋。又’食用纖維之配合量，亦可在不改變薑黃一 震稀-蓽撥之含量下，藉由將全量增加而予以增量。 1277422 又本發明之含薑黃組成物，在不損害其肝功能保護 及改"效果範圍内可配合藥學上容許之各種載體，具體而 °可配合例如，甘油脂肪酸酯及蜜蠟等安定劑；纖維素 =其何生物、澱粉及其衍生物等天然及合成高分子等賦形 J，硬知酸及其鹽類、天然及合成蠟類等潤滑劑；糖類； 酸味劑；香料等。 ’ 本發明之新穎含薑黃組成物，可因應使用條件依周知 之调製方&，製成粉⑼、粒狀、顆粒狀、微粒狀、凝膠狀、 片狀等固體狀；或糊狀、糖漿狀等液狀。 本發明之新穎含薑黃組成物，係為了肝功能之保護作 用及改善作用而被攝取。又，為了預防及/或治療肝功能障 礙而攝取。本發明之新穎含薑黃組成物，以經口攝取為佳 較好，此可藉將該含薑黃組成物含於食品、進行製劑化而 達成。 可將上述含薑黃組成物含於例如：果汁、清涼飲料、 佘、濟、麵類、豆漿、豆腐、沙拉油、調味汁、優格、果 凍、布丁、撒飯調味料、嬰兒用奶粉、糖果、蛋糕、麵包、 餅干]點心、燒烤點心、醬烤年糕片、小碎塊年糕、水 產加工品、醬料等調味料等而製成食品。本發明之含薑黃 、、且成物亦可作為食品輔助劑或食品添加劑添加於各種食 品，而製成健康食品或營養輔助食品等。 又，本發明之含薑黃組成物，可依常法之製劑化技術， 與糊精、乳糖、澱粉等賦形劑及香料、色素等加工成片劑、 錠劑、顆粒等，並以明膠等被覆而製劑化成膠囊。 11 1277422 於食品中，本發明之含薑黃組成物之含量，依食品種 類及狀態而較難統一規定，但通常以薑黃計算為100mg以 上，較佳為400mg以上。當配合量未達5〇mg時，恐無法 期望獲得經口攝取之效果。本發明之含薑黃組成物本身具 有風味，因此可考慮以使食品風味變好之目的下設定其含 量0 實施例 以下根據實施例詳細說明本發明。但本發明不受此等 之限制。 f施例1含薑黃組成物 取新鮮秋薑黃（Cwcwma /⑽g(2)l〇kg，切片、乾燥、粉 碎得薑黃粉1.32kg(薑黃素含量4%)。 將量汽粕25%、鯊稀62%、作為安定劑之甘油脂肪酸 酯6.5%及蜜蠟6·5%，攪拌2小時製得薑黃與鯊烯配合比 例約3 : 7之混合液（薑黃素含量1%)。 f施例2含薑黃組成物 將以與實施例1相同方法製得之薑黃粉lkg，以6〇% 乙醇水溶液10L萃取3次（於室溫下、攪拌丨小時），所得 萃取液經濃縮後進行冷凍乾燥，而得薑黃之乙醇萃取冷凍 乾燥粉末163g(薑黃素含量25%)。 將此薑黃乙醇萃取粉4%、鯊烯83%、作為安定劑之 甘油脂肪酸酯6.5%及蜜蠟6·5%，攪拌2小時製得薑黃與 鯊烯配合比例約3 ·· 7(以薑黃粉計算）之混合液（薑黃素含量 1 %) ° ' 12 1277422 實施例j含薑黃組成物 將以與實施例1相同方法製付之薑黃粉1 kg，以丙_ 10L萃取3次（於室溫下、攪拌1小時），所得萃取液經濃 縮後進行冷凍乾燥，而得薑黃之丙_萃取冷束乾燥粉末 179g(薑黃素含量22%)。Curcuma zedoaria (遂藏术), gas Curcuma xanthorrhiza (yellow turmeric). The turmeric-containing composition according to any one of the above 1 to 4, wherein the squalene is an unsaturated hydrocarbon contained in a deep-sea fish. 6. The turmeric-containing composition according to the above 5, wherein the squalene is an unsaturated hydrocarbon present in the liver oil of shark fish. 7. The turmeric-containing composition according to any one of the above 1 to 4, wherein the thirty-carbon burn is obtained by reducing unsaturated hydrocarbons contained in deep-sea fish or unsaturated hydrocarbons present in shark liver oil. hydrocarbon. 8. The turmeric-containing composition according to any one of the above 1 to 4, wherein the trifluorocarbon is a synthetic triacontane synthesized by using a geranium acetone and an acetylene compound as a raw material. 9. The turmeric-containing composition according to any one of the above 1 to 8, wherein the raw material containing pepper is further used as an active ingredient. 1 〇 The turmeric-containing composition according to the above 9, wherein the piperine-containing raw material is pepper and/or pupa. 11. The turmeric-containing composition according to any one of the above 1 to 10, wherein the 1277422 is further compounded with dietary fiber as an active ingredient. 12. The turmeric-containing composition according to the above 11, wherein the edible fiber is a water-soluble dietary fiber. 13. The turmeric-containing composition according to any one of the above items i to 12, which is ingested for the protective action or improvement of liver function. 14. The turmeric-containing composition according to any one of the above items 1-3, which is ingested for preventing and/or treating liver dysfunction. A food comprising the turmeric-containing composition according to any one of the above 1 to 14. A preparation according to any one of the capsule, lozenge or syrup containing the yellow composition of any one of the above 1 to 14. The novel turmeric-containing composition of the present invention is a food or auxiliary preparation composed of a composition of hai, which has excellent liver function protection and improvement effect by combining turmeric with squalene or tri- & Shows excellent liver function. The liver function of the novel turmeric-containing composition of the present invention is further enhanced by the addition of piperine. Further, since the novel three-page composition of the present invention has no side effects at all, it is extremely practical. L 1 throwing type turmeric ' used in the present invention may be a dried pulverized product of collected turmeric, and :: an organic solvent extract or a dried product thereof. The organic solvent can be used to make the organic solvent extract of the two tomb yellows known per se, and J is prepared by a known method. Drying, evaporation or drying, heating and drying, etc. === You can also use the method of self-occupation, as long as it can effectively return 8 1277422 to collect the curcumin component of curcumin, there is no particular limitation. q The type of turmeric used in the present invention can be exemplified by > c (10) (four), - autumn j yellow), (chun turmeric), Cwr (3) π (for scutellaria), or Cwcwwa A rrrr / ^ a (yellow turmeric). Among them, /(10) (autumn turmeric) is particularly good. Synthetic is a kind of acyclic three secrets, which is rich in the oil of the party fish liver oil. When it absorbs oxygen, it becomes viscous oil. W can be used directly in the liver oil-rich or can be refined using shark. Sharks can also use unsaturated hydrocarbons contained in deep-sea fish. Among them, the use of unsaturated hydrocarbons present in the liver oil of the party and fish is particularly preferred. Triacontane, a metabolite of squalene, can be obtained by reducing unsaturated hydrocarbons in deep-sea fishes or unsaturated hydrocarbons present in t fish liver oil. Further, the triacontane may be a synthetic triacontane synthesized by using aroma of acetone and an acetylene compound. Piperine, known as the spicy component of pepper, acts to increase the bioavailability of curcumin in the turmeric component. For the piperine-containing raw material containing piperine, a spice such as pepper, long pepper, or a combination thereof may be used, and it is preferred to use the sputum. It is a spice that is often used in Okinawa cuisine, also known as hip hop, gray thorns, thorns, etc. (all of which are Japanese common names). Its origin is in Japan: it is a rush, especially in the Yaeyama area, and there are many sellers as commodities. The invention may also be purchased for use in such products. Alternatively, you can use the seeds of the corpse (10) or the Ρφπ reiro/rac/wm (dry pluck) as a squid, and the household (per "/grwm (pepper) seeds 1277422 Drying and pulverizing as a pepper. 艮Used, cut-off dimension, think of ingredients that are usually not decomposed by human digestive enzymes, including water-soluble dietary fiber contained in seaweed and water-insoluble dietary fiber contained in mites. In the present invention, it is preferred to use a water-soluble dietary fiber capable of suppressing absorption of sugar, fat, cholesterol, etc., and particularly, alginic acid or alginate (sodium salt, potassium salt, etc.), indigestible dextrin, etc., but In the present invention, it can be used as long as it contains edible fiber. The above-mentioned turmeric, t-ene and/or triacontane, and piperine and/or dietary fiber can be suitably blended by a conventional formulation technique. In the turmeric-containing composition of the invention, the ratio of turmeric to squalene or tridecane is 2:8 to 5:5, and preferably 3:7 to 4:6, more preferably 3.5:6.5. The compounding ratio can be appropriately determined in consideration of the curcumin content of turmeric. When the turmeric-containing composition further contains a piperine-containing raw material, the mixing ratio of the amount of the page to the piperine-containing raw material is 1 〇: 1 to 1: 1, and preferably 5:1 to 2:1, especially 3: i Preferably, the blending ratio can be appropriately determined by considering the amount of flavin and the content of the piperine of the piperine-containing raw material. When the yellow component of the present invention further contains dietary fiber, the blending amount of the edible fiber is difficult to be uniform. It is stipulated, but it can be blended with synthetic fiber (2g~30g, preferably 4g~15g, especially better). The compounding amount can be considered in the composition of the turmeric content and the type of dietary fiber. ¥决疋. In addition, the amount of edible fiber can also be increased by increasing the total amount without changing the content of turmeric, and it is increased. 1277422 The turmeric-containing composition of the present invention is not Damage to its liver function protection and change " effect range can be combined with various pharmaceutically acceptable carriers, specifically ° can be combined with, for example, glycerin fatty acid esters and beeswax and other stabilizers; cellulose = which organisms, starch and its derivatives Natural and synthetic Molecular and other shaping J, known as acid and its salts, natural and synthetic waxes and other lubricants; sugars; sour agents; spices, etc. 'The novel turmeric-containing composition of the present invention can be prepared according to the conditions of use. The square & is made into a solid such as a powder (9), a granule, a granule, a microparticle, a gel, or a sheet; or a liquid such as a paste or a syrup. The novel turmeric-containing composition of the present invention is for the liver. It is ingested for the protective action and the improvement of the function. In addition, it is taken in order to prevent and/or treat liver dysfunction. The novel turmeric-containing composition of the present invention preferably is orally ingested, and the turmeric may be used. The composition is contained in a food product and is formulated. The turmeric-containing composition can be contained, for example, in a fruit juice, a refreshing drink, a glutinous rice, a noodle, a soy milk, a tofu, a salad oil, a sauce, a yogurt, a jelly, or the like. Foods such as puddings, rice seasonings, baby milk powder, candy, cakes, breads, biscuits, snacks, barbecue snacks, sauces, rice cakes, small pieces of rice cakes, processed fish products, sauces, etc. The turmeric containing the composition of the present invention can be added to various foods as a food adjuvant or a food additive to prepare a health food or a nutritional supplement. Further, the turmeric-containing composition of the present invention can be processed into tablets, troches, granules, etc. with gelatin, lactose, starch and other excipients, perfumes, pigments, etc. according to the formulation technique of the conventional method, and gelatin, etc. Covered and formulated into capsules. 11 1277422 In the food, the content of the turmeric-containing composition of the present invention is difficult to be uniformly defined depending on the type and state of the food, but it is usually 100 mg or more, preferably 400 mg or more, in terms of turmeric. When the compounding amount is less than 5 〇 mg, the effect of oral ingestion may not be expected. Since the turmeric-containing composition of the present invention itself has a flavor, it is conceivable to set the content thereof for the purpose of improving the flavor of the food. EXAMPLES Hereinafter, the present invention will be described in detail based on examples. However, the invention is not limited by these. f Example 1 containing turmeric composition Take fresh autumn turmeric (Cwcwma / (10) g (2) l 〇 kg, sliced, dried, crushed turmeric powder 1.32kg (curcumin content 4%). The amount of steam is 25%, shark thin 62%, glycerin fatty acid ester as a stabilizer, 6.5%, and beeswax 6.5%, stirred for 2 hours to obtain a mixture of turmeric and squalene in a ratio of about 3:7 (curcumin content of 1%). 2 The turmeric-containing composition The turmeric powder lkg obtained in the same manner as in Example 1 was extracted three times with 10 L of a 6 % aqueous ethanol solution (at room temperature, stirred for several hours), and the resulting extract was concentrated and then freeze-dried. And turmeric extract 163g of lyophilized powder (curcumin content 25%). This turmeric ethanol extract powder 4%, squalene 83%, glycerin fatty acid ester as a stabilizer 6.5% and beeswax 6.5% , stirring for 2 hours to obtain a mixture of turmeric and squalene in a ratio of about 3 · · 7 (calculated as turmeric powder) (curcumin content of 1%) ° ' 12 1277422 Example j containing turmeric composition will be with Example 1 1 kg of turmeric powder prepared by the same method, extracted 3 times with propylene 10 L (at room temperature, stirring for 1 hour), and the obtained extract was concentrated. After freeze-drying, to give the prop _ turmeric extract powder 179g cold bundle dried (curcuminoid content of 22%).
將此薑黃之丙酮萃取粉4.5%、鯊烯82.5%、作為安定 劑之甘油脂肪酸醋6 · 5 %及蜜蟻6 · 5 %，擾拌2小時製得墓 黃與鯊烯配合比例約3 ·· 7 (以量黃粉計算）之混合液（薑黃素 含量1 %)。 實施例4辅助製劑 將實施例1〜3含薑黃組成物之薑黃與鯊烯混合液 250mg，加工充填於軟膠囊製得軟膠囊劑。 實施例5食品 將實施例1〜3含薑黃組成物之薑黃與黨烯混合液 1 〇g，添加於市售天然乳酪1 〇〇g，加熱至沸點以上攪拌混 合製得含有薑黃與鯊烯之食品。The turmeric acetone extract powder 4.5%, squalene 82.5%, glycerin fatty acid vinegar 6 5 % as a stabilizer and 6 · 5 % honey ants, disturbed for 2 hours to obtain a ratio of tomb yellow and squalene about 3 · · 7 (calculated as yellow powder) (curcumin content 1%). Example 4 Auxiliary Formulations 250 mg of a mixture of turmeric and squalene containing turmeric compositions of Examples 1 to 3 were processed and filled in soft capsules to obtain a soft capsule. Example 5 Foods The turmeric and the ketone mixture containing the turmeric composition of Examples 1 to 3 was added in an amount of 1 〇g, and was added to a commercially available natural cheese 1 〇〇g, and heated to a boiling point or higher and stirred to obtain a turmeric and squalene. food.
實驗例1 飼料 將實施例1之混合液加入大鼠飼料（CRF —丨：天然酵 母）製仔量黃素含ϊ 0_2。/〇之飼料。又，將實施例1製得薑 黃粉之薑黃素含量0.2% (叢烯含量，之飼料及紧烯含量 2% (薑黃素含量0%)之飼料混合，製成比較組。對照組為 未"j、、加之飼料（CRF 1 ·天然酵母）。此等飼料供下述之試 驗0 13 1277422 方法 早斯特系白色大鼠（雄性、4週齡）在一定條件下（溫度·· 24士、濕度：55±10%、照明·· 12小時）適應3日後， 分別傲食依上述方法製得之飼料（試驗組、比較組及對照組） 7日。於帛6日除正常組外’均投予D—半乳糖胺生理食 鹽水溶液（35mg/ml)350mg/kg於腹腔内，並於〇 —半乳糖 胺投予後22小時’以戊巴比妥納麻醉下剖腹採血。 結果 使用上述方法取得之血液，測定血液中GpT及 活性，作為肝功能之指標。數值以平均值及標準偏差表示， 差異顯著性測定以t -試驗進行。 GPT活性之測定結果示於表丨，G〇T活性之測定結果 示於表2。 表1Experimental Example 1 Feed The mixture of Example 1 was added to a rat feed (CRF - 丨: natural yeast) to prepare a flavonoid containing ϊ 0_2. /〇 feed. Further, the curcumin content of turmeric powder obtained in Example 1 was 0.2% (the cedar content, the feed and the feed content of 2% (curcumin content 0%) were mixed, and the comparison group was made. The control group was not " ; j, plus feed (CRF 1 · natural yeast). These feeds are available for the following test 0 13 1277422 Method Early white white rats (male, 4 weeks old) under certain conditions (temperature · 24 士Humidity: 55±10%, illumination·12 hours) After 3 days of adaptation, the feeds prepared by the above method (test group, comparison group and control group) were respectively 7 days. On the 6th day, except for the normal group D-galactosamine physiological saline solution (35 mg/ml) 350 mg/kg was administered intraperitoneally, and laparoscopic blood was collected under pentobarbital anesthesia 22 hours after administration of sputum-galactosamine. The blood obtained was measured for GpT and activity in blood as an indicator of liver function. The values were expressed as mean and standard deviation, and the difference significance was measured by t-test. The results of GPT activity are shown in Table 丨, G〇T activity The measurement results are shown in Table 2. Table 1
GPT活性之差異顯著性測定（t -試驗） 實施例1(薑黃+鯊烯）組之GPT活性，與對照組、比 較例（僅薑黃）組及比較例（僅鯊烯）組比較時，其之上升受到 抑制，於5 %顯著水準平均上為顯著差異。 1277422 表2 組別 個體數 GOT活性平均 值(IU/L) 標準偏差 實施例1(薑黃+鯊烯)組 7 859.8 + 89.212 比較例(僅薑黃)組 7 1,677.8 + 120.013 比較例(僅第、烯)組 7 4,968.1 ±247.047 對照組 7 5,070.9 +259.025 正常組 7 128.9 +2.43 GOT活性之差異顯著性測定（t -試驗） 實施例1 (薑黃+鯊烯）組之GOT活性，與對照組、比 較例（僅薑黃）組及比較例（僅鯊烯）組比較時，其之上升受到 抑制，於5%顯著水準平均上為顯著差異。 實施例6食品（醬烤年糕片） 將以與實施例1相同方法製得之薑黃粉15g，加入鯊 烯25g、蓽撥5g、食用纖維200g、食鹽2〇g及米粉末3〇〇g， 再加適量水攪拌，製造薑黃、鯊烯、蓽撥、食用纖維之配 合比例約3:5: 1:40(以薑黃粉計算）之糊狀物。將此拉 伸、細切、乾燥後以烘箱燒烤製成醬烤年糕片（薑黃素含量 0.1%)。 此醬烤年糕片1包18g中含有薑黃45〇mg、鯊烯 750mg、食用纖維6g、及蓽撥150mg。 A…施例7食品（小碎塊年糕） 將以與實施例1相同方法所製得之薑黃粉9g，加入鯊 烯15g、蓽撥3g、食鹽6g及海帶粉6g攪拌，製得薑黃y 鯊烯、蓽撥、食用纖維之配合比例約3 : 5 ••丨：1(以薑今 粉計算）之糊狀物。將此迅速混入3〇〇g糯米搗製之年糕中， 充分揉搓混和後拉伸並於4。(：放置丨夜以上。將此取出細 15 1277422 切、乾燥後燒烤製成小碎塊年糕。 此小碎塊年糕丨包18 75〇mg、食用3有量貝450mg、鯊烯 g艮用纖維200叫、及蓽撥150mg。 广P月之含薑黃組成物，藉由含薑黃外再含鯊烯，而 無副作用且具有優異之肝功能保護及改善作用，故該組成 物可作為食品或輔助製劑利用。X，本發明之含薑土组成 物含有胡椒鹼時，且有更優显 K，、成 〃有更優異之肝功能保護及改善效果， J S作風味良好之健廉合口 €康食°口利用。再者，本發明之含薑黃 制作含有食用纖維時，具有糖、脂肪、膽固醇之吸收抑 剩作用’可作為減肥食品利用。 【圖式簡單說明】 無 【主要元件符號說明】 無Significant difference in GPT activity (t-test) GPT activity in the Example 1 (turmeric + squalene) group was compared with the control group, the comparative example (turmeric only) group, and the comparative example (squalene only) group. The rise was suppressed and was significantly different on a 5% significant level. 1277422 Table 2 Mean GOT activity average (IU/L) Standard deviation Example 1 (Curcuma + squalene) group 7 859.8 + 89.212 Comparative example (turmeric only) group 7 1,677.8 + 120.013 Comparative example (only, ene Group 7 4,968.1 ± 247.047 Control group 7 5,070.9 +259.025 Normal group 7 128.9 +2.43 Significant difference in GOT activity (t - test) GOT activity of Example 1 (turmeric + squalene) group, with control group, comparative example When the (only turmeric) group and the comparative example (squalene only) group were compared, the increase was suppressed, and the average level was significantly different at 5%. Example 6 Food (Sauce Roasted Rice Cake Pieces) 15 g of turmeric powder obtained in the same manner as in Example 1 was added, 25 g of squalene, 5 g of squalene, 200 g of edible fiber, 2 g of salt, and 3 g of rice powder. Add a suitable amount of water and stir to prepare a paste of turmeric, squalene, sorghum, and dietary fiber in a ratio of about 3:5: 1:40 (calculated as turmeric powder). This was stretched, finely cut, dried, and then roasted in an oven to prepare a sauce roast rice cake piece (curcumin content 0.1%). This sauce roast rice cake piece contains 18 g of turmeric 45 g, squalene 750 mg, dietary fiber 6 g, and 150 mg. A...Example 7 Food (small pieces of rice cake) 9 g of turmeric powder obtained in the same manner as in Example 1 was added with squalene 15 g, 3 g of squalene, 6 g of salt and 6 g of kelp powder to obtain a turmeric y shark. The blend ratio of ene, plucked, and dietary fiber is about 3:5 ••丨:1 (calculated as ginger powder). This was quickly mixed into a 3 〇〇g glutinous rice cake, fully blended and then stretched at 4. (: Place the day and night. Take this out of the fine 15 1277422, cut, dry and bake to make a small piece of rice cake. This small piece of rice cake is wrapped with 18 75〇mg, edible 3 quantity of shellfish 450mg, squalene fiber 200, and 150mg. The turmeric composition of the broad P month, with squalene containing turmeric, without side effects and excellent liver function protection and improvement, so the composition can be used as food or auxiliary Formulation utilization. X, the ginger-containing soil composition of the present invention contains piperine, and has a better K, and has better liver function protection and improvement effect, and JS has a good flavor and a healthy joint. In addition, when the turmeric-containing preparation of the present invention contains edible fiber, it has the effect of absorbing sugar, fat, and cholesterol, which can be used as a diet food. [Simple description of the figure] No [Main component symbol description] None