KR20060054339A - Turmeric-containing composition - Google Patents

Abstract

It is intended to provide a novel composition containing turmeric which is capable of fully exhibiting usefulness in protecting and improving liver functions. Namely, a turmeric-containing composition characterized by containing turmeric together with squalene or squalane as the active ingredients. This turmeric-containing composition may further contain piperine and/or dietary fiber. As a result, this novel composition has a remarkable effect of protecting and improving liver functions and a synergistic protecting and improving effect can be established compared with the cases where these ingredients are each employed alone.

Description

Turmeric-containing composition {TURMERIC-CONTAINING COMPOSITION}

The present invention relates to a novel turmeric containing composition. More specifically, a novel turmeric-containing composition based on a mixture of turmeric and squalene or squalene, and a new turmeric-containing composition in which piperine and / or plant fibers are mixed. It is about.

The present invention is based on the usefulness of the novel turmeric containing composition in the protection and improvement of liver function.

This application claims priority from Japanese Patent Application No. 2003-325276 and Japanese Patent Application No. 2004-188519, which are incorporated herein by reference.

Conventionally, amino acid preparations, glutathione, hepatic hydrolysates, herbal medicines and the like are used as hepatitis function improving agents, but the effects are alleviated and the effects are excellent. As a plant-derived composition, it is known that ginseng, Maria azami, turmeric, etc. have an effect on improving gastric function, but the effect is not sufficient.

On the other hand, squalene and squalene are components of deep sea shark liver oil, which are said to have the effects of cell reactivation, immune enhancing, antioxidant, analgesic, bactericidal, and invasive. No report of improvement can be found.

In addition, edible oils and fats containing an oil-soluble ingredient eluted from turmeric have been disclosed (Japanese Patent Laid-Open No. 2001-86931), but it contains curcumin, squalene or squalene as an active ingredient and improves liver function. There are no reports of compositions showing effect.

Piperine is a pungent ingredient of pepper, and it has been reported that piperine increases the biological effectiveness of curcumin in turmeric (Guido Shoba et al . Planta Medica 64 (1998) 353-356). It has been disclosed to combine curcumin with piperine as an active ingredient to prevent and treat inflammatory bowel disease (Japanese Patent Laid-Open No. 2001-86931). There are no reports of such compositions containing three components of curcumin, squalene or squalene, piperine.

Patent Document 2: Japanese Patent Laid-Open No. 2003-55202

Turmeric contains curcumin and essential oils, and has been used as a medicine or tonic for a long time as a herbal medicine for hepatitis, gastroenteritis cholangitis, cholelithiasis and gastritis. However, curcumin and essential oil components, which are active ingredients of turmeric, are hydrophobic, so absorption is poor, and the effect of improving liver function cannot be said to be sufficient as that of other plant-derived compositions. The problem of this invention is providing the composition which can fully exhibit the usefulness in liver function protection and improvement function by providing a novel turmeric containing composition.

In order to solve the above problems, the present inventors have reviewed the combination of turmeric with squalene or squalene, and as a result, the novel composition has a significant liver function protection and improvement effect, and furthermore, to use them alone. The present invention has been completed by finding that synergistically the effect of protecting and improving liver function is increased.

That is, this invention is as follows.

1. The turmeric containing composition which mixes turmeric with squalene or squalene, and mixes turmeric with squalene or squalene with a ratio of 2: 8-5: 5.

2. The turmeric containing composition of item 1, wherein the turmeric is a dry ground powder or an organic solvent extract or dried product.

3. The turmeric-containing composition according to item 2, wherein the organic solvent extract contains curcumin, which is a component of turmeric.

4. The turmeric-containing composition according to any one of items 1 to 3, wherein the turmeric is autumn turmeric, spring turmeric, Curcuma zedoaria or Curcuma xanthorrhiza .

5. The turmeric-containing composition according to any one of items 1 to 4, wherein squalene is an unsaturated hydrocarbon contained in fish of deep sea acid.

6. The turmeric containing composition of item 5, wherein squalene is an unsaturated hydrocarbon present in the liver oil of sharks.

7. The turmeric-containing composition according to any one of items 1 to 4, wherein squalene is an unsaturated hydrocarbon obtained by reducing unsaturated hydrocarbons contained in fish of deep sea acid or liver oil of shark fish.

8. The turmeric-containing composition according to any one of items 1 to 4, wherein squalene is a synthetic squalene obtained by synthesizing a geranyl acetone and an acetylene compound as raw materials.

9. The turmeric-containing composition according to any one of items 1 to 8, further comprising a pipelin-containing material as an active ingredient.

10. The turmeric-containing composition according to item 9, wherein the piperine-containing material is pepper and / or piper retrofractum (or collectively referred to as Hihats ).

11. The turmeric-containing composition according to any one of items 1 to 10, further comprising plant fiber as an active ingredient.

12. The turmeric-containing composition according to item 11, wherein the plant fiber is a water soluble plant fiber.

13. The turmeric-containing composition according to any one of items 1 to 12, which is ingested for protecting or improving liver function.

14. The turmeric-containing composition according to any one of items 1 to 13, which is ingested for the prevention and / or treatment of liver failure.

15. A food product comprising the turmeric-containing composition according to any one of claims 1 to 14.

16. A formulation made from a formulation of any of capsules, tablets or syrups comprising the turmeric containing composition of any of claims 1-14.

 The novel turmeric-containing composition of the present invention has excellent liver function protection and amelioration by combining turmeric with squalene or squalene, and the food and supplement preparations made from the composition It shows excellent liver function protection and improvement. The liver function protection and amelioration of the novel turmeric containing composition of the present invention is further enhanced by incorporating pipelin. Moreover, the novel turmeric-containing composition of the present invention has very high effectiveness since there are no side effects.

The turmeric used in the present invention may be a dry pulverized product of the collected turmeric, or an organic solvent extract thereof or a dried product thereof. The organic solvent can use acetone, ethanol, etc. suitably. Turmeric organic solvent extracts are known per se and can be prepared by known means. Drying may be used in addition to freeze drying, drying by natural drying, or heating drying. The treatment is not particularly limited as long as curcumin, which is a component of turmeric, can be efficiently recovered.

The type of turmeric used in the present invention is autumn turmeric ( Curcuma longa ), Curcuma aromatica , Curcuma zedoaria ) or Curcuma xanthorrhiza . Particularly preferred turmeric is Curcuma longa .

Squalene is one of the acyclic triterpenes and is a colorless oil that is often found in fish liver oils. Oxygen is absorbed into the viscous oil. Squalane may be used as it is, natural products containing a large amount of fatty oil or the like, or may be purified. Squalene may use unsaturated hydrocarbons contained in the fish of the deep sea. Especially preferably, unsaturated hydrocarbons present in the liver oil of sharks are used.

Squalane is a metabolite of squalene, which can be obtained by reducing unsaturated hydrocarbons contained in deep-sea fish, or unsaturated hydrocarbons present in liver oil of sharks.

The squalene may be a synthetic squalene obtained by synthesizing a geranyl acetone and an acetylene compound as raw materials.

Piperine is known as a spicy ingredient of pepper and acts to increase the bioavailability of curcumin, which is a component of turmeric.

As a piperin-containing material including piperine, spices such as pepper, piper retrofractum, or a combination thereof can be used. Among them, piper retrofraction is preferable. Pfeiffer Retrofractum is a spice that is frequently used in Okinawan cuisine and is also called Pivats, Piparts, and Pachipa. In Japan, Okinawa is the main province in the province of Palzhong, and many of them come to the market as commodities. In the present invention, these products can be obtained and used. Or Hi Hearts includes, for example pilbal (Piper longum ) or Piper retrofractum dried and ground fruit may be used.

Plant fiber generally refers to a component that is not decomposed by human digestive enzymes, and there are plant fibers contained in water-soluble plant fibers and flesh products contained in seaweed. In the present invention, it is preferable to use a water-soluble vegetable fiber which inhibits absorption of sugars, fats, cholesterol, and the like, and alginic acid or alginate (sodium salt, potassium salt, etc.), indigestible dextrin, and the like are suitable. In the present invention, even ones such as those containing plant fibers can be used.

Such turmeric and squalene or squalene, and also piperine and / or plant fibers are suitably blended by conventional formulation techniques.

In the turmeric containing composition of the present invention, the blending ratio of turmeric, squalene or squalene is 2: 8 to 5: 5, more preferably 3: 7 to 4: 6, and more preferably For example, 3.5: 6.5. This compounding ratio is suitably determined in consideration of curcumin content of turmeric.

In the case where the turmeric-containing composition of the present invention further includes a piperine-containing material, the blending ratio of the piperine-containing material to turmeric is 10: 1 to 1: 1, more preferably 5: 1 to 2: 1. , More preferably 3: 1. This compounding ratio is suitably determined in consideration of curcumin content of turmeric and the piperine content of the piperine-containing material.

In the case where the turmeric-containing composition of the present invention further contains plant fibers, the blending amount of plant fibers is difficult to define uniformly, but the daily intake of plant fibers is 2 g to 30 g, more preferably 4 g to 15 g, and more preferably It can mix | blend so that it may become 6 g. This amount is appropriately determined in consideration of the curcumin content in the composition, the type of plant fiber, and the like.

In addition, the amount of plant fiber can be increased by increasing the total volume without changing the content of turmeric-squaraine-Hihatsu.

In addition, the turmeric-containing composition of the present invention may be formulated with various pharmaceutically acceptable carriers in a range that does not impair the effect of protecting and improving liver function, and specifically, stabilizers such as glycerin fatty acid esters and meatloaf. Excipients such as cellulose and its derivatives, starch and its leading edges and synthetic polymers, stearic acid and its salts, lubricants such as lead and synthetic wax oils, sugars, sour flavors and fragrances.

The novel turmeric-containing composition of the present invention may be solid, such as powder form, particle form, granule form, fine grain form, gum form, trorch form, or paste form or syrup form by a known preparation method according to the conditions to be used. It can be liquid.

The novel turmeric-containing compositions of the present invention are ingested for the protection or amelioration of liver function. It is also taken for the prevention and / or treatment of liver failure. The novel turmeric-containing composition of the present invention is preferably ingested orally, which can be achieved by containing or formulating the turmeric-containing composition in food.

The turmeric containing composition is, for example, juice. Soft drinks, tea, soups, tofu, soy milk, miso (natto), salad oil, dressing, yogurt, jelly, pudding, furigake, baby formula, candy, cakes, bread, cookies, snaps, baked sweets, senbei sweets, It can also be contained in seasonings, such as fried foods, a processed fish product, a sauce, etc., and can also be used as food. The turmeric containing composition of this invention can be added to various foods as a food supplement or a food additive, and can be made into a health food, a nutritional supplement, etc.

In addition, the turmeric-containing composition of the present invention is processed into pellets, tablets, granules, or the like with excipients such as dextrin, lactose, starch, etc., flavorings, pigments, etc., or coated with gelatin to form capsules by a conventional formulation method. It is also possible.

Although the turmeric containing composition in the foodstuff of this invention cannot be prescribed | regulated uniformly according to the kind and state of a foodstuff, it is usually 100 mg or more, preferably 400 mg or more as turmeric. If the amount is less than 50 mg, there is a fear that the effect of oral intake cannot be expected. Since the turmeric containing composition of this invention has its own flavor, it is also possible to set content, considering the objective of improving the flavor of food.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, this invention is not limited to these.

Example  One: curcuma  Containing composition

Raw Curcuma 10 kg of longa ) was sliced, dried and pulverized to obtain 1.32 kg of turmeric powder (curcumin content 4%).

Add 25% turmeric powder, 62% squalene, and 6.5% glycerin fatty acid ester and 6.5% mildew as stabilizer, and stir for 2 hours. %) Was prepared.

Example  2: Turmeric  Composition

1 kg of turmeric powder obtained in the same manner as in Example 1 was extracted three times (10 ° C, stirred for 1 hour) in 10% of 60% ethanol aqueous solution (condensation at room temperature, 1 hour). The extract was concentrated and freeze-dried powder of turmeric ethanol extract (curcumin Content 25%) 163g was obtained.

Add 4% of this ethanol extract powder, 83% squalene, and 6.5% glyceline fatty acid ester as a stabilizer and 6.5% meatloaf and stir for 2 hours, and mix the turmeric and squalene with a ratio of about 3: 7 (turmeric powder) A mixed liquid (curcumin content 1%) was prepared.

Example  3: Turmeric  Composition

1 kg of turmeric powder obtained in the same manner as in Example 1 was extracted three times with 10 L of acetone (after stirring at room temperature for 1 hour), followed by concentration and freeze-drying of the turmeric acetone extract (22% curcumin content). 179 g was obtained.

4.5% of this acetone extract powder, 82.5% squalene, and 6.5% glycerin fatty acid ester and 6.5% meatloaf as a stabilizer were added and stirred for 2 hours, and the mixture ratio of turmeric and squalene was about 3: 7 (calculated turmeric powder). A mixed liquid (curcumin content 1%) was prepared.

Example  4: additive ( Supplement Formulation

250 mg of turmeric and squalene mixed solution, which are the turmeric-containing compositions of Examples 1 to 3, were filled into a soft capsule to prepare a soft capsule.

Example  5: food

10 g of turmeric and squalene mixtures, which are the turmeric-containing compositions of Examples 1 to 3, were added to 100 g of commercially available natural cheese to perform superheat stirring, to prepare turmeric and squalene containing foods.

Experimental Example  One

Feed: A feed having a curcumin content of 0.2% was prepared by adding the mixed solution of Example 1 to the feed of rats (CRF-1: Oriental Yeast). As a comparative group, a curcumin content (% curcumin content 0%) and a curcumin content 2% feed (curcumin content 0%) were prepared by mixing turmeric powder obtained in Example 1. The control group was made with no additives (CRF-1: Oriental Yeast). Their feed was provided for the next test.

Method: Wistar rats (male, 4 weeks old) were acclimated for 3 days under constant conditions (temperature 24 ± 2 ° C., humidity 55 ± 10%, illumination: 12 hours), and then prepared as described above. Feed (test group, control group, and control group) was taken for 7 days each. On the 6th day, the normal group was removed, and 350 mg / kg of D-GARAKUTOSAMUN physiological saline solution (35 mg / ml) was administered intraperitoneally, and 22 hours after the administration of D-Garakutosa, nenbutal The blood was collected and opened under anesthesia.

Results: The blood thus obtained was used to measure the activity of GPT and GOT in blood as an indicator of liver function. Values are expressed as mean and standard error, and significant difference test was performed by t-test.

Table 1 shows the results of measuring GPT activity and Table 2 shows the results of GOT activity.

group Number of individuals GPT Active Average (IU / L) Standard Deviation Example 1 (turmeric + squaraine) 7 599 ± 91.80 Comparative Example (Turmeric Bay) 7 1,165.2 ± 123.59 Comparative Example (Sukuwaren Bay) 7 1,936.2 ± 288.34 Control 7 1,996.7 ± 286.00 Normal 7 20.7 ± 2.43

Significance test of GPT activity (t-test)

Example 1 (turmeric + squalene) group GPT activity is suppressed in comparison with those of the control group, Comparative Example (only turmeric) group and Comparative Example (squalene group), at a significance level of 5% There was a significant difference in the mean.

group Number of individuals GOT active average value (IU / L) Standard Deviation Example 1 (turmeric + squaraine) 7 859.8 ± 89.212 Comparative Example (Turmeric Bay) 7 1,677.8 ± 120.013 Comparative Example (Sukuwaren Bay) 7 4,968.1 ± 247.047 Control group 7 5,070.9 ± 259.025 Normal 7 128.9 ± 2.43

Significance test of GOT activity (t-test)

Example 4 (turmeric + squaraine) group GOT activity is suppressed in comparison with those of the control group, Comparative Example (only turmeric) group and Comparative Example (Squalane only) group, at a significance level of 5% There was a significant difference in the mean.

Example  6: food ( Senbei sweets )

15 g of turmeric powder obtained in the same manner as in Example 1, 25 g of squalene, 5 g of piper retrofractum, 200 g of plant fiber, 20 g of salt, and 300 g of rice flour were added, followed by stirring with a suitable amount of water. And a blending ratio of plant fiber of about 3: 5: 1: 40 (turmeric powder equivalent) was prepared. This was elongated, chopped, dried, and baked into oven-baked senbei (curcumin 0.1%).

One 18g of senbei sweets contained 450mg of turmeric, 750mg of squalene, and 150mg of Pfeiffer Retrofratum 6g of plant fiber.

Example  7: Food (frying)

9 g of turmeric powder obtained in the same manner as in Example 1, 15 g of squalene, 3 g of piper retrofractum, 6 g of salt, and 6 g of kelp were added and stirred, and the blending ratio of turmeric, squaraine and pivat was about 3: 5: 1: A paste of 1 (turmeric powder equivalent) was prepared. It was attached to 300 g of glutinous rice, quickly mixed with rice cake, kneaded well and elongated, and left overnight at 4 ° C.

Take out, chopped and dried, and baked to prepare a frying pan.

One 18 g of fried frying contains 450 mg of turmeric, 750 mg of squalene, and 200 mg of plant fiber 200 mg Pfeiffer Retrofratum.

The turmeric-containing composition of the present invention contains squalene in addition to turmeric, so that it is not adhered and has excellent liver function protection and improvement, so that the composition can be used as a food and supplement preparation. In addition, as a turmeric-containing composition of the present invention, when piperine is contained, it has better liver function protection and improvement effect, and can be used as a healthy food with a good flavor. Has the effect of inhibiting the absorption of sugars, fats and cholesterol and can be used in diet foods and the like.

Claims (16)

Turmeric-containing composition, characterized in that the combination of turmeric and squalene (squalene) or squalene (squalane), the ratio of turmeric and squalene or squalene (squalane) is 2: 8 ~ 5: 5. 2. The turmeric-containing composition according to claim 1, wherein the turmeric is a dry ground powder or an organic solvent extract or dried product. 3. The turmeric-containing composition according to claim 2, wherein the organic solvent extract contains curcumin, which is a component of turmeric. Wherein the first to third according to any one of items, turmeric fall turmeric, turmeric spring, ahchul (Curcuma zedoaria) or greater kyuma nagging chair (Curcuma turmeric-containing composition, characterized in that any one of xanthorrhiza ). The turmeric-containing composition according to any one of claims 1 to 4, wherein squalene is an unsaturated hydrocarbon contained in the fish of the deep sea. 6. The turmeric-containing composition according to claim 5, wherein squalene is an unsaturated hydrocarbon present in the liver oil of sharks. The turmeric-containing composition according to any one of claims 1 to 4, wherein squalene is an unsaturated hydrocarbon which is obtained by reducing unsaturated hydrocarbons contained in fish of deep sea or in the liver oil of sharks. . 5. The turmeric-containing composition according to any one of claims 1 to 4, wherein squalene is a synthetic squalene obtained by synthesizing a geranyl acetone and an acetylene compound as raw materials. The turmeric-containing composition according to any one of claims 1 to 8, further comprising a pipelin-containing material as an active ingredient. 10. The turmeric-containing composition according to claim 9, wherein the piperine-containing material is pepper and / or piper retrofractum. The turmeric-containing composition according to any one of claims 1 to 10, further comprising plant fibers as an active ingredient. 12. The turmeric content composition of claim 11, wherein the plant fiber is a water soluble plant fiber. 13. The turmeric-containing composition according to any one of claims 1 to 12, which is ingested for protecting or improving liver function. The turmeric-containing composition according to any one of claims 1 to 13, which is ingested for the prevention and / or treatment of liver failure. Food containing the turmeric containing composition of any one of Claims 1-14. A formulation comprising any of the formulations of a capsule, tablet or syrup comprising the turmeric-containing composition of any one of claims 1-14.