CN100394977C - Turmeric-containing composition - Google Patents
Turmeric-containing composition Download PDFInfo
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- CN100394977C CN100394977C CNB2004800209308A CN200480020930A CN100394977C CN 100394977 C CN100394977 C CN 100394977C CN B2004800209308 A CNB2004800209308 A CN B2004800209308A CN 200480020930 A CN200480020930 A CN 200480020930A CN 100394977 C CN100394977 C CN 100394977C
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- rhizoma curcumae
- curcumae longae
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Abstract
It is intended to provide a novel composition containing turmeric which is capable of fully exhibiting usefulness in protecting and improving liver functions. Namely, a turmeric-containing composition characterized by containing turmeric together with squalene or squalane as the active ingredients. This turmeric-containing composition may further contain piperine and/or dietary fiber. As a result, this novel composition has a remarkable effect of protecting and improving liver functions and a synergistic protecting and improving effect can be established compared with the cases where these ingredients are each employed alone.
Description
Technical field
The present invention system contains the Rhizoma Curcumae Longae constituent about a kind of novelty.In detail, be to be that the novelty of main component contains the Rhizoma Curcumae Longae constituent, and the novelty of remix piperine and/or edible fiber contain the Rhizoma Curcumae Longae constituent about mixture with Rhizoma Curcumae Longae and zamene or three decanes.The present invention is that the serviceability that contains the liver function-protecting of Rhizoma Curcumae Longae constituent and improve function according to novelty constitutes.
Background technology
About hepatic function remedial agent in the past, be to use amino acid preparation, bran Guang sweet (glutathione), liver hydrolysate, Chinese medicine etc., effect excellence person is very few but its effect relaxes.As for constituent from plant, improve effect though claim Tienchi-Ginseng, Herba Silybi mariani (Milk thistle), Rhizoma Curcumae Longae etc. to have liver function, its effect does not still claim fully.
On the other hand, zamene and three decanes are the liver oil composition of deep-sea shark, though weighing-appliance has effects such as cell activation effect, immunologic facilitation effect, antioxidation, analgesic effect, bactericidal action, osmosis, does not see that it improves the report of effect relevant for liver function.
Though disclosed the edible oil and fat (patent documentation 1) that contain by the turmeric oil soluble components of Rhizoma Curcumae Longae extracting, do not see to contain to show that as effective ingredient liver function improves the report of the constituent of effect with curcumin, zamene or three decanes again.
Piperine is the pungency component of Fructus Piperis, has report to point out that piperine can promote the biological effectiveness of the contained curcumin of Rhizoma Curcumae Longae (non-patent literature 1).Cooperate curcumin and piperine as effective ingredient simultaneously, with prevention, therapeutic agent also revealed (patent documentation 1) as the inflammatory bowel disease patient.Yet, do not see and contain curcumin, zamene or 3 kinds of reports that become the constituent of branch such as three decanes, piperine.
Patent documentation 1: the spy opens 2001-86931
Patent documentation 2: the spy opens 2003-55202
Non-patent literature 1:Guido Shoba et al.Planta Medica 64 (1998): 353-356
Summary of the invention
Rhizoma Curcumae Longae contains curcumin and derived essential oil etc., from ancient times promptly as a kind of Chinese medicine and as uses such as the curative of hepatitis, kidney inflammation, biliary tract inflammation, cholelithiasis and gastritis etc. or the medicines that keeps healthy.Yet because the effective ingredient curcumin of Rhizoma Curcumae Longae and derived essential oil are hydrophobicity and absorbability is poor, effect is identical with other constituents from plant can't to deserve to be called enough so its liver function is improved.The present invention's problem, what be to provide novelty contains the Rhizoma Curcumae Longae constituent, and using provides the constituent that can give full play to the liver protecting function and improve function.
The inventor is for solving above-mentioned problem; discussion cooperates Rhizoma Curcumae Longae with zamene or three decanes result; find that novel constituent has apparent liver function-protecting and improves effect, and find to use more separately these more can multiplicity ground increase liver function-protecting and improve effect, and finish the present invention.
That is the present invention is made of following:
1. one kind contains the Rhizoma Curcumae Longae constituent, it is characterized by Rhizoma Curcumae Longae is cooperated with zamene or three decanes, and the ratio that cooperates of Rhizoma Curcumae Longae and zamene or three decanes is 2: 8～5: 5.
As above-mentioned 1 contain the Rhizoma Curcumae Longae constituent, wherein, Rhizoma Curcumae Longae is that xeraphium minces or organic solvent extraction thing or its dry thing.
As above-mentioned 2 contain the Rhizoma Curcumae Longae constituent, wherein, contain the curcumin that Rhizoma Curcumae Longae becomes branch in the organic solvent extraction thing.
As above-mentioned 1～3 each contain the Rhizoma Curcumae Longae constituent, wherein, Rhizoma Curcumae Longae is Curcuma longa (autumn Rhizoma Curcumae Longae), Curcuma aromatica (spring Rhizoma Curcumae Longae), Curcuma zedoaria (Rhizoma Curcumae) or Curcumaxanthorrhiza (xanthorrhiza Rhizoma Curcumae Longae).
As above-mentioned 1～4 each contain the Rhizoma Curcumae Longae constituent, wherein, zamene is the contained unsaturated hydrocarbons of abyssal fishes.
As above-mentioned 5 contain the Rhizoma Curcumae Longae constituent, wherein, zamene is for being present in the unsaturated hydrocarbons in the shark class liver oil.
As above-mentioned 1～4 each contain the Rhizoma Curcumae Longae constituent, wherein, three decanes are for the unsaturated hydrocarbons that abyssal fishes are contained or be present in unsaturated hydrocarbons in the shark class liver oil, the saturated hydrocarbons that reduction forms.
As above-mentioned 1～4 each contain the Rhizoma Curcumae Longae constituent, wherein, three decanes are for being synthetic three decanes of the synthetic gained of raw material with Herba Pelargonii Graveolentis grass acetone and acetylide.
As above-mentioned 1～8 each contain the Rhizoma Curcumae Longae constituent, wherein, further cooperate and contain the piperine raw material as effective ingredient.
As above-mentioned 9 contain the Rhizoma Curcumae Longae constituent, wherein, containing the piperine raw material is Fructus Piperis and/or Fructus Piperis Longi.
11. as above-mentioned 1～10 each contain the Rhizoma Curcumae Longae constituent, wherein, further matched fiber is as effective ingredient.
12. as above-mentioned 11 contain the Rhizoma Curcumae Longae constituent, wherein, edible fiber is a water solutable edible fiber.
13. as above-mentioned 1～12 each contain the Rhizoma Curcumae Longae constituent, it has been the protective effect of liver function or improvement effect and be ingested.
14. as above-mentioned 1～13 each contain the Rhizoma Curcumae Longae constituent, it has been prevention and/or treatment hepatic insufficiency and be ingested.
15. a food, its contain as above-mentioned 1～14 each contain the Rhizoma Curcumae Longae constituent.
16. a preparation, it is made to contain as above-mentioned 1～14 each arbitrary dosage form of the capsule that contains the Rhizoma Curcumae Longae constituent, lozenge or syrup.
The present invention's novelty contains the Rhizoma Curcumae Longae constituent, by Rhizoma Curcumae Longae is cooperated with zamene or three decanes, and for having excellent liver function-protecting and improve effect person, and by food or auxiliary agent that this constituent constitutes, also manifest the liver function-protecting of excellence and improve effect.The present invention's novelty contains the liver function-protecting of Rhizoma Curcumae Longae constituent and improves effect, more strengthens because of cooperating piperine again.And the present invention's novelty contains the Rhizoma Curcumae Longae constituent owing to have no side effect fully, so practicality is high.
The specific embodiment
Organic solvent extraction thing or its dry thing are minced, also be can be to Rhizoma Curcumae Longae used herein, the xeraphium that can be the Rhizoma Curcumae Longae of collection.Organic solvent can suitably use acetone, ethanol etc.The organic solvent extraction thing of Rhizoma Curcumae Longae can be according to known method modulation originally as known person.Drying except that lyophilization, also can be utilized natural evaporation drying or heat drying etc.Its processing method is as long as composition curcumin person that can the efficient recovery Rhizoma Curcumae Longae is not particularly limited.
Rhizoma Curcumae Longae kind used herein can be given an example as Curcuma longa (autumn Rhizoma Curcumae Longae), Curcumaaromatica (spring Rhizoma Curcumae Longae), Curcuma zedoaria (Rhizoma Curcumae) or Curcuma xanthorrhiza (xanthorrhiza Rhizoma Curcumae Longae).Serve as special good wherein with Curcuma longa (autumn Rhizoma Curcumae Longae).
Zamene is a kind of of non-annularity triterpene, is the water white oil that is rich in shark class liver oil.Then become viscous oil when absorbing oxygen.Zamene can directly use the natural goods that is rich in liver oil etc., maybe can use refining zamene.Zamene also can use the contained unsaturated hydrocarbons of abyssal fishes.Wherein the unsaturated hydrocarbons that is present in the shark class liver oil with use serves as special good.
Three decanes are the metabolite of zamene, can or be present in the unsaturated hydrocarbons reduction in the shark class liver oil and make unsaturated hydrocarbons that abyssal fishes contained.Again, also to can be with Herba Pelargonii Graveolentis grass acetone and acetylide be synthetic three decanes of the synthetic gained of raw material to three decanes.
Piperine is known as the pungency component of Fructus Piperis, and it act as and improves the organism utilization rate that Rhizoma Curcumae Longae becomes the curcumin of branch.
What contain piperine contains the piperine raw material, can use spices such as Fructus Piperis, Fructus Piperis Longi (Indian long pepper) or its combination, wherein to use Fructus Piperis Longi preferable.Fructus Piperis Longi for often being used in the spice of Okinawa cooking, claims again that plucked string instrument with a fretted fingerboard is breathed out now, tufa sour jujube, plucked string instrument with a fretted fingerboard China sour jujube etc. the Japanese popular name of Fructus Piperis Longi (more than be).Its place of production is Okinawa in Japan, especially based on area, eightfold mountain, as commodity and commercially available person is a lot of.The present invention also can buy these commodity and use.Perhaps, also seed drying, the pulverizing of Piper longum (Fructus Piperis Longi) or Piper retrofractum (plan Fructus Piperis Longi) can be used as Fructus Piperis Longi, and seed drying, the pulverizing of Piper nigrum (Fructus Piperis) are used as Fructus Piperis.
Edible fiber, meaning usually wherein to be had contained water-insoluble edible fibers such as contained water solutable edible fiber of Sargassum and frumentum by the composition of human consumption ferment decomposition.In the present invention, the water solutable edible fiber that can suppress the absorption of sugar, fat, cholesterol etc. with use is good, especially suitableeer with alginic acid or alginate (sodium salt, potassium salt etc.), indigestible dextrins etc., but in the present invention as long as the person all can use in order to contain the edible fiber.
As above-mentioned Rhizoma Curcumae Longae and zamene and/or three decanes, and piperine and/or edible fiber, can suitably cooperate by the preparation technology of well-established law.
The present invention contains in the Rhizoma Curcumae Longae constituent, and Rhizoma Curcumae Longae is 2: 8～5: 5 with the ratio that cooperates of zamene or three decanes, and is good with 3: 7～4: 6, especially with 3.5: 6.5 for better.This cooperation ratio can be considered the curcumin content of Rhizoma Curcumae Longae and suitably decision.
During the containing the Rhizoma Curcumae Longae constituent and further contain the piperine raw material of the present invention, Rhizoma Curcumae Longae is 10: 1～1: 1 to the cooperation ratio that contains the piperine raw material, and with 5: 1～2: 1 be good, especially with 3: 1 for better.This cooperation ratio can be considered the curcumin content of Rhizoma Curcumae Longae and contain the content of piperine of piperine raw material and suitably decision.
During the containing the Rhizoma Curcumae Longae constituent and further contain edible fiber of the present invention, the difficult unified regulation of edible fiber use level, but can fit in the daily intake (2g～30g is good with 4g～15g, especially with 6g for better) of edible fiber.This use level can be considered Rhizoma Curcumae Longae content in the constituent and edible fiber kind etc. and suitably decision.Again, the use level of edible fiber also can give increment by full dose is increased under the content that does not change Rhizoma Curcumae Longae-zamene-Fructus Piperis Longi.
Again, the present invention contains the Rhizoma Curcumae Longae constituent, can cooperate the various carriers of pharmaceutically allowing in the effective scope not damaging its liver function-protecting and improve, and particularly, for example can cooperate tranquilizers such as fatty acid glyceride and Apis cerana Fabricius; Excipient such as natural and synthetic high polymer such as cellulose and derivant thereof, starch and derivant thereof; Lubricants such as stearic acid and its esters, natural and synthetic wax class; Saccharide; Acidic flavoring agent; Spice etc.
The present invention's novelty contains the Rhizoma Curcumae Longae constituent, can be in response to service condition according to known modulator approach, make solid, shaped such as powdery, granular, graininess, microgranular, gel, lamellar; Or pasty state, syrupy shape etc. are aqueous.
The present invention's novelty contains the Rhizoma Curcumae Longae constituent, has been the protective effect of liver function and improvement effect and be ingested.Again, in order to prevent and/or to treat hepatic insufficiency and absorb.The present invention's novelty contains the Rhizoma Curcumae Longae constituent, with oral uptake be good better, be contained in food, carry out preparationization and reach but this mat contains the Rhizoma Curcumae Longae constituent with this.
The above-mentioned Rhizoma Curcumae Longae constituent that contains for example can be contained in: fruit juice, refreshment drink, tea, soup, Noodles, bean milk, bean curd, salad oil, sauce, yogurt, fruit jelly, pudding, remove flavouring agents such as the roasting new year cake sheet of meal flavouring agent, milk powder for baby, confection, cake, bread, cookies, biscuit, barbecue dessert, beans, fine grained chippings new year cake, aquatic products processing product, sauce etc. and food prepared therefrom.The present invention contains the Rhizoma Curcumae Longae constituent, also can be used as food adjuvant or food additive and makes an addition to various food, and make health food or dietary supplement etc.
Again, the present invention contains the Rhizoma Curcumae Longae constituent, can be according to the preparation technology of well-established law, be processed into tablet, lozenge, granule etc. with excipient such as dextrin, lactose, starch and spice, pigment etc., and with linings such as gelatin and preparation changes into capsule.
In food, the present invention's the content that contains the Rhizoma Curcumae Longae constituent according to food variety and state and difficult unified regulation, but is calculated as more than the 100mg with Rhizoma Curcumae Longae usually, is preferably more than the 400mg.When use level does not reach 50mg, probably can't expect to obtain the effect of oral uptake.The present invention's the Rhizoma Curcumae Longae constituent that contains itself has local flavor, therefore can consider so that set its content under the purpose that flavour of food products improves.
Embodiment
Followingly describe the present invention in detail according to embodiment.But the present invention is not subjected to these restriction.
Embodiment 1Contain the Rhizoma Curcumae Longae constituent
Get fresh autumn Rhizoma Curcumae Longae (Curcuma longa) 10kg, section, dry, pulverize curcuma powder 1.32kg (curcumin content 4%).
With curcuma powder 25%, zamene 62%, as the fatty acid glyceride 6.5% and the Apis cerana Fabricius 6.5% of tranquilizer, stir and made Rhizoma Curcumae Longae in 2 hours and cooperate about 3: 7 mixed liquor of ratio (curcumin content 1%) with zamene.
Embodiment 2Contain the Rhizoma Curcumae Longae constituent
Will be with the curcuma powder 1kg that makes with embodiment 1 same procedure, with 60% ethanol water 10L extraction 3 times (under room temperature, stirred 1 hour), the gained extract carries out lyophilization after concentrating, and gets the alcohol extraction lyophilization powder 163g (curcumin content 25%) of Rhizoma Curcumae Longae.
With this Rhizoma Curcumae Longae alcohol extraction powder 4%, zamene 83%, as the fatty acid glyceride 6.5% and the Apis cerana Fabricius 6.5% of tranquilizer, stir and made Rhizoma Curcumae Longae cooperates about 3: 7 of ratio (calculating with curcuma powder) with zamene mixed liquor (curcumin content 1%) in 2 hours.
Embodiment 3Contain the Rhizoma Curcumae Longae constituent
Will be with the curcuma powder 1kg that makes with embodiment 1 same procedure, with acetone 10L extraction 3 times (under room temperature, stirred 1 hour), the gained extract carries out lyophilization after concentrating, and gets the acetone extract lyophilization powder 179g (curcumin content 22%) of Rhizoma Curcumae Longae.
With the acetone extract powder 4.5% of this Rhizoma Curcumae Longae, zamene 82.5%, as the fatty acid glyceride 6.5% and the Apis cerana Fabricius 6.5% of tranquilizer, stir and made Rhizoma Curcumae Longae cooperates about 3: 7 of ratio (calculating with curcuma powder) with zamene mixed liquor (curcumin content 1%) in 2 hours.
Embodiment 4Auxiliary agent
Embodiment 1～3 is contained the Rhizoma Curcumae Longae and the zamene mixed liquor 250mg of Rhizoma Curcumae Longae constituent, and the processing filling makes soft capsule in soft capsule.
Embodiment 5Food
Embodiment 1～3 is contained the Rhizoma Curcumae Longae and the zamene mixed liquor 10g of Rhizoma Curcumae Longae constituent, make an addition to commercially available natural cheese 100g, be heated to mix more than the boiling point and make the food that contains Rhizoma Curcumae Longae and zamene.
Experimental example 1
Feedstuff
The mixed liquor of embodiment 1 is added rat feed (CRF-1: unartificial yeast) make the feedstuff of curcumin content 0.2%.Again, embodiment 1 is made the feedstuff of curcumin content 0.2% (zamene content 0%) of curcuma powder and the feedstuff of zamene content 2% (curcumin content 0%) and mix, make comparable group.Matched group is the feedstuff (CRF-1: unartificial yeast) of not interpolation.These feedstuffs are for following test.
Method
West be white rat (male, 4 week ages) under certain condition (temperature: 24 ± 2 ℃, humidity: 55 ± 10%, illumination: 12 hours) adapt to 3 after, the feedstuff (test group, comparable group and matched group) that makes according to said method of feeding is 7 respectively.In the 6th day except that normal group, all throw and give D-galactosamine normal saline solution solution (35mg/ml) 350mg/kg, and throw in D-galactosamine and to give back 22 hours, with the blood sampling of cutting open the belly under the pentobarbital sodium anesthesia in intraperitoneal.
The result
The blood that uses said method to obtain is measured GPT and GOT activity in the blood, as the index of liver function.Numerical value represents that with meansigma methods and standard deviation showing property of difference mensuration is carried out with the t-test.
The measurement result of GPT activity is shown in table 1, and the measurement result of GOT activity is shown in table 2.
Table 1
| Group | Number of individuals | The active meansigma methods (IU/L) of GPT | Standard deviation |
| Embodiment 1 (Rhizoma Curcumae Longae+zamene) group | 7 | 599 | ±91.80 |
| Comparative example (only Rhizoma Curcumae Longae) group | 7 | 1,165.2 | ±123.59 |
| Comparative example (only zamene) group | 7 | 1,936.2 | ±288.34 |
| Matched group | 7 | 1,996.7 | ±286.00 |
| Normal group | 7 | 20.7 | ±2.43 |
Showing property of the difference mensuration of GPT activity (t-test)
The GPT activity of embodiment 1 (Rhizoma Curcumae Longae+zamene) group, when comparing with matched group, comparative example (only Rhizoma Curcumae Longae) group and comparative example (only zamene) group, liter is suppressed on it, is showing level in 5% and is on average going up to showing difference.
Table 2
| Group | Number of individuals | The active meansigma methods (IU/L) of GOT | Standard deviation |
| Embodiment 1 (Rhizoma Curcumae Longae+zamene) group | 7 | 859.8 | ±89.212 |
| Comparative example (only Rhizoma Curcumae Longae) group | 7 | 1,677.8 | ±120.013 |
| Comparative example (only zamene) group | 7 | 4,968.1 | ±247.047 |
| Matched group | 7 | 5,070.9 | ±259.025 |
| Normal group | 7 | 128.9 | ±2.43 |
Showing property of the difference mensuration of GOT activity (t-test)
The GOT activity of embodiment 1 (Rhizoma Curcumae Longae+zamene) group, when comparing with matched group, comparative example (only Rhizoma Curcumae Longae) group and comparative example (only zamene) group, liter is suppressed on it, is showing level in 5% and is on average going up to showing difference.
Embodiment 6Food (beans is baked the new year cake sheet)
Will be with the curcuma powder 15g that makes with embodiment 1 same procedure, add zamene 25g, Fructus Piperis Longi 5g, edible fiber 200g, Sal 20g and rice flour end 300g, add suitable quantity of water again and stir, about 3: 5: 1 of the cooperation ratio of manufacturing Rhizoma Curcumae Longae, zamene, Fructus Piperis Longi, edible fiber: the pastel of 40 (calculating) with curcuma powder.With this stretching, fritter, dry back makes the roasting new year cake sheet (curcumin content 0.1%) of beans with the baking oven barbecue.
Contain Rhizoma Curcumae Longae 450mg, zamene 750mg, edible fiber 6g among the roasting new year cake sheet 1 bag 18g of this beans, reach Fructus Piperis Longi 150mg.
Embodiment 7Food (fine grained chippings new year cake)
Will be with the curcuma powder 9g obtained with embodiment 1 same procedure, add zamene 15g, Fructus Piperis Longi 3g, Sal 6g and Thallus Laminariae (Thallus Eckloniae) powder 6g and stir, make about 3: 5: 1 of the cooperation ratio of Rhizoma Curcumae Longae, zamene, Fructus Piperis Longi, edible fiber: the pastel of 1 (calculating) with curcuma powder.This is sneaked into rapidly in the new year cake of 300g Oryza glutinosa ramming, fully rub mixed after-drawing and place more than 1 night in 4 ℃.With this taking-up fritter, dry after burning bake becomes the fine grained chippings new year cake.
Among this fine grained chippings new year cake 1 bag 18g, contain Rhizoma Curcumae Longae 450mg, zamene 750mg, edible fiber 200mg, reach Fructus Piperis Longi 150mg.
The present invention contains the Rhizoma Curcumae Longae constituent, contains zamene outward again by containing Rhizoma Curcumae Longae, and the liver function-protecting and the improvement effect that have no side effect and have excellence, so this constituent can be used as food or auxiliary agent utilization.Again, during the containing the Rhizoma Curcumae Longae constituent and contain piperine of the present invention, have more excellent liver function-protecting and improve effect, can be used as the health food utilization of excellent flavor.Moreover, during the containing the Rhizoma Curcumae Longae constituent and contain edible fiber of the present invention, have the absorption inhibitory action of sugar, fat, cholesterol, can be used as the diet food utilization.
Claims (8)
- One kind prevent and/or treat hepatic insufficiency contain the Rhizoma Curcumae Longae compositions, it is that Rhizoma Curcumae Longae is cooperated with zamene or three decanes, and the ratio that cooperates of Rhizoma Curcumae Longae and zamene or three decanes is 2: 8～5: 5.
- 2. contain the Rhizoma Curcumae Longae compositions according to claim 1, wherein, this Rhizoma Curcumae Longae is that xeraphium minces or organic solvent extraction thing or its dry thing.
- 3. as containing the Rhizoma Curcumae Longae compositions as described in the claim 2, wherein, contain the curcumin that Rhizoma Curcumae Longae becomes branch in this organic solvent extraction thing.
- 4. contain the Rhizoma Curcumae Longae compositions according to claim 1, wherein, this Rhizoma Curcumae Longae is autumn Rhizoma Curcumae Longae (Curcumalonga), spring Rhizoma Curcumae Longae (Curcuma aromatica), Rhizoma Curcumae (Curcuma zedoaria) or xanthorrhiza Rhizoma Curcumae Longae (Curcuma xanthorrhiza).
- 5. contain the Rhizoma Curcumae Longae compositions according to claim 1, wherein, this zamene is the unsaturated hydrocarbons that abyssal fishes contain.
- 6. as containing the Rhizoma Curcumae Longae compositions as described in the claim 5, wherein, this zamene system is present in the unsaturated hydrocarbons in the shark class liver oil.
- 7. contain the Rhizoma Curcumae Longae compositions according to claim 1, wherein, this three decane is the unsaturated hydrocarbons that abyssal fishes are contained or be present in the saturated hydrocarbons that the unsaturated hydrocarbons reduction in the shark class liver oil forms.
- 8. contain the Rhizoma Curcumae Longae compositions according to claim 1, wherein, this three decane is to be synthetic three decanes of the synthetic gained of raw material with Herba Pelargonii Graveolentis grass acetone and acetylide.
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