TWI225412B - Liposome-entrapped polynucleotide composition and method - Google Patents
Liposome-entrapped polynucleotide composition and method Download PDFInfo
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- TWI225412B TWI225412B TW087109984A TW87109984A TWI225412B TW I225412 B TWI225412 B TW I225412B TW 087109984 A TW087109984 A TW 087109984A TW 87109984 A TW87109984 A TW 87109984A TW I225412 B TWI225412 B TW I225412B
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- fat
- polynucleotide
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- solvent
- fatty
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
- A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
Landscapes
- Health & Medical Sciences (AREA)
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- Genetics & Genomics (AREA)
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- Biotechnology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Dispersion Chemistry (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
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| US5049097P | 1997-06-23 | 1997-06-23 |
Publications (1)
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| TWI225412B true TWI225412B (en) | 2004-12-21 |
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| TW087109984A TWI225412B (en) | 1997-06-23 | 1998-06-22 | Liposome-entrapped polynucleotide composition and method |
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| US (1) | US6120798A (OSRAM) |
| EP (1) | EP1017365B1 (OSRAM) |
| JP (1) | JP2002508765A (OSRAM) |
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| AU (1) | AU7983798A (OSRAM) |
| CA (1) | CA2294579C (OSRAM) |
| DE (1) | DE69820465T2 (OSRAM) |
| DK (1) | DK1017365T3 (OSRAM) |
| ES (1) | ES2212305T3 (OSRAM) |
| TW (1) | TWI225412B (OSRAM) |
| WO (1) | WO1998058630A1 (OSRAM) |
Families Citing this family (84)
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| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| US7309692B1 (en) * | 1996-07-08 | 2007-12-18 | Board Of Regents, The University Of Texas System | Inhibition of chronic myelogenous leukemic cell growth by liposomal-antisense oligodeoxy-nucleotides targeting to GRB2 or CRK1 |
| US6977244B2 (en) | 1996-10-04 | 2005-12-20 | Board Of Regents, The University Of Texas Systems | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US6056973A (en) * | 1996-10-11 | 2000-05-02 | Sequus Pharmaceuticals, Inc. | Therapeutic liposome composition and method of preparation |
| US7262173B2 (en) * | 1997-03-21 | 2007-08-28 | Georgetown University | Chemosensitizing with liposomes containing oligonucleotides |
| US6559129B1 (en) * | 1997-03-21 | 2003-05-06 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
| US6126965A (en) * | 1997-03-21 | 2000-10-03 | Georgetown University School Of Medicine | Liposomes containing oligonucleotides |
| US20030229040A1 (en) * | 1997-03-21 | 2003-12-11 | Georgetown University | Cationic liposomal delivery system and therapeutic use thereof |
| US7285288B1 (en) | 1997-10-03 | 2007-10-23 | Board Of Regents, The University Of Texas System | Inhibition of Bcl-2 protein expression by liposomal antisense oligodeoxynucleotides |
| US7704962B1 (en) | 1997-10-03 | 2010-04-27 | Board Of Regents, The University Of Texas System | Small oligonucleotides with anti-tumor activity |
| EP1150658B1 (en) * | 1999-02-08 | 2004-08-04 | Alza Corporation | Method for controlling liposome size |
| US7223406B2 (en) | 2000-07-21 | 2007-05-29 | The Regents Of The University Of California | Methods and compositions for preventing and treating male erectile dysfunction and female sexual arousal disorder |
| WO2002007757A2 (en) | 2000-07-21 | 2002-01-31 | Lue Tom F | Prevention and treatment of sexual arousal disorders |
| US20020146829A1 (en) * | 2000-11-29 | 2002-10-10 | Aventis Pharmaceuticals Products Inc. | Neutral and anionic colloidal particles for gene delivery |
| US6610322B1 (en) * | 2000-12-20 | 2003-08-26 | Brian Charles Keller | Self forming, thermodynamically stable liposomes and their applications |
| US20030077829A1 (en) * | 2001-04-30 | 2003-04-24 | Protiva Biotherapeutics Inc.. | Lipid-based formulations |
| KR100411234B1 (ko) * | 2001-08-14 | 2003-12-18 | 한국과학기술원 | 올리고뉴클레오티드 혼성화 미셀 및 그의 제조방법 |
| EP1460898A4 (en) * | 2002-01-03 | 2006-05-24 | Univ Texas | WT1 ANTISENSE OLIGOS FOR THE INHIBITION OF BREAST CANCER |
| KR100466254B1 (ko) * | 2002-02-25 | 2005-01-14 | 한국과학기술원 | 세포내 전달을 위한 올리고뉴클레오티드와 친수성 고분자로 구성되는 유전자 전달용 접합체, 고분자 전해질 복합 미셀 및 그의 제조방법 |
| EP1509203B1 (en) * | 2002-05-15 | 2016-04-13 | California Pacific Medical Center | Delivery of nucleic acid-like compounds |
| US20030219696A1 (en) * | 2002-05-23 | 2003-11-27 | Moreland Gerald W. | Method and apparatus for preventing backflow in dental saliva evacuators |
| JP4975964B2 (ja) | 2002-06-26 | 2012-07-11 | メディゲーネ アクチエンゲゼルシャフト | 脂肪親和性化合物から成る陽イオン性リポソームの製法 |
| EP1519714B1 (en) * | 2002-06-28 | 2010-10-20 | Protiva Biotherapeutics Inc. | Method and apparatus for producing liposomes |
| AU2002953285A0 (en) * | 2002-12-12 | 2003-01-02 | Protech Research Pty Ltd | Yeast treatment |
| US20070178066A1 (en) | 2003-04-21 | 2007-08-02 | Hall Frederick L | Pathotropic targeted gene delivery system for cancer and other disorders |
| ES2366617T3 (es) | 2003-04-21 | 2011-10-21 | Epeius Biotechnologies Corporation | Métodos y composiciones para el tratamiento de transtornos. |
| CA2566079A1 (en) * | 2004-05-12 | 2005-12-01 | Terrence L. Scott | Nucleic acid microspheres, production and delivery thereof |
| WO2006133022A2 (en) | 2005-06-03 | 2006-12-14 | The Johns Hopkins University | Compositions and methods for decreasing microrna expression for the treatment of neoplasia |
| US20070087045A1 (en) * | 2005-10-14 | 2007-04-19 | Industrial Technology Research Institute | Lipid carrier and method of preparing the same |
| WO2007080902A1 (ja) | 2006-01-11 | 2007-07-19 | Kyowa Hakko Kogyo Co., Ltd. | 眼球において標的遺伝子の発現を抑制する組成物および眼球における疾患の治療剤 |
| US20110091377A1 (en) | 2007-05-11 | 2011-04-21 | The Johns Hopkins University | Biomarkers for melanoma |
| PL208054B1 (pl) * | 2007-09-06 | 2011-03-31 | Akademia Medyczna Im Piastow Śląskich We Wrocławiu | Kompozycja lipidowa do wytwarzania lipidowego nośnika dla leków genetycznych i jej zastosowanie |
| CA2710983A1 (en) * | 2007-12-27 | 2009-10-01 | The Ohio State University Research Foundation | Lipid nanoparticle compositions and methods of making and using the same |
| WO2009137095A2 (en) | 2008-05-08 | 2009-11-12 | The Johns Hopkins University | Compositions and methods for modulating an immune response |
| WO2010013815A1 (ja) | 2008-08-01 | 2010-02-04 | 協和発酵キリン株式会社 | 標的遺伝子の発現を抑制する組成物 |
| JP2012520683A (ja) | 2009-03-19 | 2012-09-10 | メルク・シャープ・エンド・ドーム・コーポレイション | 低分子干渉核酸（ｓｉＮＡ）を用いた結合組織増殖因子（ＣＴＧＦ）遺伝子発現のＲＮＡ干渉媒介性阻害 |
| WO2010107958A1 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION 6 (STAT6) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| WO2010107957A2 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF GATA BINDING PROTEIN 3 (GATA3) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
| CA2755773A1 (en) | 2009-03-19 | 2010-09-23 | Merck Sharp & Dohme Corp. | Rna interference mediated inhibition of btb and cnc homology 1, basic leucine zipper transcription factor 1 (bach 1) gene expression using short interfering nucleic acid (sina) |
| WO2010111468A2 (en) | 2009-03-27 | 2010-09-30 | Merck Sharp & Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE NERVE GROWTH FACTOR BETA CHAIN (NGFß) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (SINA) |
| EP2411520A2 (en) | 2009-03-27 | 2012-02-01 | Merck Sharp&Dohme Corp. | RNA INTERFERENCE MEDIATED INHIBITION OF THE THYMIC STROMAL LYMPHOPOIETIN (TSLP) GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA) |
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| US5855911A (en) * | 1995-08-29 | 1999-01-05 | Board Of Regents, The University Of Texas System | Liposomal phosphodiester, phosphorothioate, and P-ethoxy oligonucleotides |
| FR2751222B1 (fr) * | 1996-07-16 | 1998-10-09 | Capsulis | Compositions contenant au moins un acide nucleique et leurs applications dans le domaine biomedical, en particulier en therapie genique |
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1998
- 1998-06-22 ES ES98930447T patent/ES2212305T3/es not_active Expired - Lifetime
- 1998-06-22 CA CA002294579A patent/CA2294579C/en not_active Expired - Fee Related
- 1998-06-22 AU AU79837/98A patent/AU7983798A/en not_active Abandoned
- 1998-06-22 TW TW087109984A patent/TWI225412B/zh not_active IP Right Cessation
- 1998-06-22 JP JP50493699A patent/JP2002508765A/ja not_active Abandoned
- 1998-06-22 EP EP98930447A patent/EP1017365B1/en not_active Expired - Lifetime
- 1998-06-22 WO PCT/US1998/012937 patent/WO1998058630A1/en not_active Ceased
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- 1998-06-22 DE DE69820465T patent/DE69820465T2/de not_active Expired - Fee Related
- 1998-06-22 AT AT98930447T patent/ATE255882T1/de not_active IP Right Cessation
- 1998-06-23 US US09/103,341 patent/US6120798A/en not_active Expired - Lifetime
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| DK1017365T3 (da) | 2004-03-29 |
| ATE255882T1 (de) | 2003-12-15 |
| CA2294579C (en) | 2007-10-09 |
| ES2212305T3 (es) | 2004-07-16 |
| EP1017365B1 (en) | 2003-12-10 |
| US6120798A (en) | 2000-09-19 |
| DE69820465D1 (de) | 2004-01-22 |
| DE69820465T2 (de) | 2004-09-16 |
| WO1998058630A1 (en) | 1998-12-30 |
| EP1017365A1 (en) | 2000-07-12 |
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