TWI223599B - Evaluation method of matrix metalloprotease inhibitory activity - Google Patents

Evaluation method of matrix metalloprotease inhibitory activity Download PDF

Info

Publication number
TWI223599B
TWI223599B TW089109933A TW89109933A TWI223599B TW I223599 B TWI223599 B TW I223599B TW 089109933 A TW089109933 A TW 089109933A TW 89109933 A TW89109933 A TW 89109933A TW I223599 B TWI223599 B TW I223599B
Authority
TW
Taiwan
Prior art keywords
film
sample
activity
inhibitory activity
mmp
Prior art date
Application number
TW089109933A
Other languages
English (en)
Chinese (zh)
Inventor
Ryuji Maekawa
Takayuki Yoshioka
Ryoichi Nemori
Yutaka Tamura
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Application granted granted Critical
Publication of TWI223599B publication Critical patent/TWI223599B/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/81—Protease inhibitors
    • G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96486—Metalloendopeptidases (3.4.24)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Enzymes And Modification Thereof (AREA)
TW089109933A 1999-05-24 2000-05-23 Evaluation method of matrix metalloprotease inhibitory activity TWI223599B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP14330899 1999-05-24
JP21214599 1999-07-27

Publications (1)

Publication Number Publication Date
TWI223599B true TWI223599B (en) 2004-11-11

Family

ID=26475073

Family Applications (1)

Application Number Title Priority Date Filing Date
TW089109933A TWI223599B (en) 1999-05-24 2000-05-23 Evaluation method of matrix metalloprotease inhibitory activity

Country Status (9)

Country Link
US (1) US6627411B2 (fr)
EP (1) EP1181939B1 (fr)
JP (1) JP4070409B2 (fr)
AT (1) ATE328111T1 (fr)
AU (1) AU4779800A (fr)
DE (1) DE60028372T2 (fr)
ES (1) ES2265345T3 (fr)
TW (1) TWI223599B (fr)
WO (1) WO2000071167A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001054399A (ja) * 1999-08-18 2001-02-27 Fuji Photo Film Co Ltd プロテアーゼ阻害作用を有する医薬の有効性の判定方法
AUPQ826500A0 (en) 2000-06-21 2000-07-13 Novapharm Research (Australia) Pty Limited Enzyme detection and measurement
JP2006516548A (ja) 2002-12-30 2006-07-06 アンジオテック インターナショナル アクツィエン ゲゼルシャフト 迅速ゲル化ポリマー組成物からの薬物送達法
ATE433115T1 (de) * 2004-07-28 2009-06-15 Hoffmann La Roche Timp-2 als ziel/marker des versagens von beta- zellen

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4373993A (en) * 1992-05-14 1993-12-13 Ohio State University Research Foundation, The Treatment of vascular leakage syndrome and collagenase induced disease by administration of matrix metalloproteinase inhibitors
WO1994005807A1 (fr) * 1992-08-28 1994-03-17 Dickson Robert B Metalloproteinase decomposant les matrices
DE69721507T2 (de) 1996-02-29 2004-03-25 Fuji Photo Film Co., Ltd., Minami-Ashigara Verfahren zur analyse von proteasen und dünne membran zur verwendung in diesem verfahren
JPH1045632A (ja) * 1996-07-26 1998-02-17 Meiji Milk Prod Co Ltd 腸管免疫系に対して免疫応答誘導能を有 する蛋白質由来ペプチド類の検索方法
JPH11127896A (ja) * 1997-10-24 1999-05-18 Fuji Photo Film Co Ltd 乾式多層分析素子

Also Published As

Publication number Publication date
WO2000071167A1 (fr) 2000-11-30
DE60028372D1 (de) 2006-07-06
EP1181939B1 (fr) 2006-05-31
JP4070409B2 (ja) 2008-04-02
DE60028372T2 (de) 2007-05-03
ES2265345T3 (es) 2007-02-16
EP1181939A4 (fr) 2004-09-27
ATE328111T1 (de) 2006-06-15
AU4779800A (en) 2000-12-12
EP1181939A9 (fr) 2002-04-24
US6627411B2 (en) 2003-09-30
EP1181939A1 (fr) 2002-02-27
US20030157585A1 (en) 2003-08-21

Similar Documents

Publication Publication Date Title
Zhang et al. Autophagy preserves the osteogenic ability of periodontal ligament stem cells under high glucose conditions in rats
Li et al. Detection of matrix metallopeptidase 13 for monitoring stem cell differentiation and early diagnosis of osteoarthritis by fluorescent light‐up probes with aggregation‐induced emission characteristics
AU2008341105A1 (en) Novel devices for the detection of the presence and/or activity of proteases in biological samples
ES2484696T3 (es) Método de identificación de inhibidores de paraqueratosis epidérmica
Siar et al. Epithelial-to-mesenchymal transition in ameloblastoma: focus on morphologically evident mesenchymal phenotypic transition
Ghazaryan et al. The antitumor efficacy of monomeric disintegrin obtustatin in S-180 sarcoma mouse model
TWI223599B (en) Evaluation method of matrix metalloprotease inhibitory activity
JP2958327B2 (ja) 異常上皮細胞剥離の検出方法
RU2694882C1 (ru) Способ прогнозирования рецидива эндометриоидных кист яичника
Borrowman et al. Cutaneous nodular amyloidosis masquerading as a foot callus
Russell et al. B-glucuronidase activity of gastric juice in gastric carcinoma.
JPH07503323A (ja) 選択的なマーカーとしてアルストニンを用いる細胞診断方法及び前記のマーカーを含有する診断キット
Buonvino et al. Modelling the disease: H2S-sensitivity and drug-resistance of triple negative breast cancer cells can be modulated by embedding in isotropic micro-environment
RU2612082C1 (ru) Способ прогнозирования направленности патологического процесса при раке головки поджелудочной железы
EP0231005B1 (fr) Trousse et procédé pour la détermination de l'activité de prolifération des tumeurs humaines
EP1085097B1 (fr) Procédé pour le jugement de l'éfficacité des inhibiteurs de protéases
Fakhouri High Throughput 3D Hydrogel Cell and Tissue Encapsulation Assay to Measure Matrix Metalloproteinase and Metabolic Activity
Dai et al. Co-Expression Pattern of Artemis Serine 516 Phosphorylation with Indicators Involving in Differentiation, Proliferation and Apoptosis of Human Anagen Hair Follicles: An Immunofluorescence Double-Staining Study
McDowell et al. Exogenous APN protects normal tissues from radiation-induced oxidative damage and fibrosis in mice and prostate cancer patients with higher levels of APN have less radiation-induced toxicities
US20130273519A1 (en) Composition for treating blood and set of diagnostic kit comprising the same to detect autoimmune disease
KR100502440B1 (ko) 비정상적 상피세포의 박리를 측정하는 방법
US20050250164A1 (en) Design of novel drug screens based on the newly found role of dystroglycan proteolysis in tumor cell growth
Griffith et al. Exploration into chronic wounds on the left lower leg yields unlikely diagnosis
Celli et al. Endoplasmic reticulum Ca.
Watkins An investigation into minichromosomal maintenance proteins (MCMs) for the diagnosis of prostate cancer, as a possible alternative to prostate specific antigen (PSA)

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees