TW542723B - Oral composition - Google Patents
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542723 A7 B7 五、發明說明（1 ) 本發明之背景 本發明之領域 本發明係關於一種含有丹寧的口腔用組成物，且特別 是關於一種含有丹寧並混合有甘草精萃出物以降低由丹寧 導生出來之苦味的口腔用組成物，因而可提供一於使用時 具有較佳口感的含丹寧口腔用組成物。 先前技藝之說明 丹寧配用在口腔用組成物內係爲已知（日本專利公開 公報59—152311)。由於丹寧具有天然苦味，因 此配用有丹寧之口腔用組成物於使用時具有口感上之障礙 〇 尤其是當將一種由對於口腔疾病具有醫學攻效之生藥 導生出之含丹寧的組份配用一 口腔用組成物，以使得該含 丹寧之組份的添加量足以產生一令人滿意的醫學攻效，卻 由於內含丹寧之苦味而使口感變得較差。因此，蘊釀出改 善含丹寧之口腔用組成物口感的需要。 本發明之摘要 本發明之目的在於提供一種含丹寧之口腔用組成物， 其中由丹寧導生出之苦味被降到最低且其使用時具較佳口 感。 根據本發明之上述目的可藉由一含有丹寧混合以甘草 精萃出物的口腔用組成物而達成。 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再本頁) 一再士542723 A7 B7 V. Description of the invention (1) Field of the invention The present invention relates to an oral composition containing tannins, and in particular to a tannin-containing and mixed liquorice extract to reduce The bitter oral composition derived from tannins can provide a tannin-containing oral composition having a better taste when used. Description of the prior art It is known that tannins are used in oral compositions (Japanese Patent Laid-Open Publication 59-152311). Because tannins have a natural bitter taste, oral compositions containing tannins have a mouthfeel barrier when used. Especially when a tannin-containing group derived from a biopharmaceutical that has medical effects on oral diseases is used. An oral composition is formulated so that the amount of the tannin-containing component is sufficient to produce a satisfactory medical effect, but the taste is poor due to the bitterness of the tannin. Therefore, there is a need to improve the taste of oral compositions containing tannins. SUMMARY OF THE INVENTION The object of the present invention is to provide an oral composition containing tannins, in which the bitterness induced by tannins is minimized and has a good taste when used. The above object according to the present invention can be achieved by an oral composition containing tannin blended with licorice extract. This paper size applies to China National Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before this page)
一σι、雪 1 — I I I I 經濟部智慧財產局員工消費合作社印製 -4- 542723 A7 _^ B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（2 ) 本發明之詳細說明 ， 根據本發明之口腔用組成物含有丹寧及甘草精萃出物 〇 丹寧可廣泛的分級爲兩類，包括可水解的丹寧，其中 掊醯基或其衍生物係接合至糖或環狀多元醇，及包括稠含 丹寧，其包含黃烷- 3 -醇或其衍生物的冷凝物。該稠合 丹寧係黃烷- 3 -醇或其衍生物之冷凝物，例如兒茶酸， 表兒茶酸，表兒茶酸掊酸鹽，表掊兒茶酸，表掊兒茶酸掊 酸鹽等。此類型之丹寧通常可由生藥或植物取得。本發明 中所使用的丹寧可爲任一種。在此，使用稠合丹寧較佳， 尤其是以含丹寧組份形成或由生藥或植物之萃出物形式。 在生藥中，以得自兒茶，春黃菊，猶牛兒苗，茶葉，薄荷 ’蛇麻，粟子，蜂花，桃子，迷送香，鼠尾草，及草苺虎 耳草者爲最佳。於製備方法中，分子量及稠合程度並非絕 對的。 丹寧或含丹寧組份（或萃出物）於口腔用組成物中的 含量範圍宜爲由〇·〇〇〇〇〇1至〇.01%重量（於 下文中簡化爲％)，最好爲由0.00001至 0 〇〇1%之丹寧。如果含量少於〇·〇〇〇〇〇1% ，丹寧的功效無法令人滿意的顯現。在另外一方面，當含 量超過0 · 0 1 %時，該組成物會因丹寧而顯色。如此會 造成視覺上或想像或喜好觀點上的負面影響。 本發明之口腔用組成物係配含有甘草精萃出物。甘草 (請先閱讀背面之注意事項再本頁) 再 訂---------族一 σι, snow 1 — IIII Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs -4- 542723 A7 _ ^ B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (2) Detailed description of the invention, according to this The oral composition of the invention contains tannin and licorice extract. Tannin can be broadly classified into two types, including hydrolysable tannin, in which the fluorenyl group or its derivative is linked to a sugar or a cyclic polyol, And includes thick tannins containing condensate of flavan-3-ol or its derivatives. The condensate of the fused tannin-flavan-3 alcohol or its derivatives, such as catechin, epicatechin, epicatechin, catechin, epicatechin, epicatechin Acid salt etc. Tannins of this type are usually obtained from crude drugs or plants. Any of the tannins used in the present invention may be used. Here, the use of fused tannins is preferred, especially in the form of tannin-containing components or extracts of crude drugs or plants. Among the crude drugs, those derived from catechin, chamomile, hemp seedlings, tea leaves, mint 'hops, millet, bee flowers, peaches, mimosa, sage, and strawberry saxifraga are the best. In the preparation method, the molecular weight and the degree of condensation are not absolute. The content of tannin or a tannin-containing component (or extract) in the oral composition should preferably range from 0.0000 to 0.01% by weight (hereinafter, it is simplified to%), and most It is better to have tannin from 0.00001 to 0.001%. If the content is less than 0.0000%, the effect of tannin cannot be satisfied. On the other hand, when the content exceeds 0.01%, the composition may develop color due to tannin. This can have a negative impact on vision or imagination or preference. The oral composition of the present invention contains a licorice extract. Licorice (Please read the notes on the back before this page)
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -5- 542723 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（3 ) 精萃出物的含量範圍宜爲組成物之0 . 0 0 1至0 . 2 % 。如果含量少於0 · 0 0 1 %，丹寧的功效無法令人滿意 的顯現。而當含量超過0 · 2 %時，甘草精的口味在喜好 觀點上會對組成物造成負面影響。 根據本發明之口腔用組成物可視潔牙劑之形式製成， 例如，牙膏，牙粉，潔牙液等，漱口水及口腔用冷凍劑。 在此，爲此目的而經常使用之成份亦可拌入該口腔用組成 物中。 例如，磨鈾劑，其包括矽石磨鈾劑，例如沈澱的矽石 ，矽膠，矽酸鋁，矽酸锆等，磷酸氫鈣二水合物及酐，焦 磷酸鈣，磷酸鈣，磷灰石氫氧化物，磷灰石氟化物，無鈣 磷灰石，四元磷酸鈣，八元磷酸鈣，碳酸鈣，氫氧化鋁， 氧化鋁，碳酸鎂，三元磷酸鎂，不溶的偏磷酸鎂，不溶的 偏磷酸鈣，二氧化鈦，沸石，矽酸鋁，矽酸锆，全成樹脂 磨蝕刻等。這些可單獨使用或合倂使用。於一潔牙組成物 中，其含量範圍通亨爲〇至9 0%，宜爲1 0至80%。 濕潤劑之實施例包括甘油，山梨糖醇，丙烯乙二醇， 聚乙烯乙二醇等。這些可單獨使用或合倂使用。其含量範 圍通常爲組成物的1 0至8 0 %。 黏合劑之實施例包括羧酸甲基纖維素鈉，角叉菜，羥 基乙基纖維素，藻朊酸鈉，黃蓍膠，聚丙烯酸鈉，蝗蟲豆 膠，CarbopQle ©，瓜拉膠，蒙脫土等。這些可單獨使用或 合倂使用。含量範圍通常爲〇至5%。 可調配之表面活性劑包括陰離子表面活性劑，陽離子 (請先閱讀背面之注意事項再本頁) 再· 1!111This paper size applies to Chinese National Standard (CNS) A4 (210 X 297 mm) -5- 542723 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (3) The content of the extract should be in the appropriate range It is from 0.01 to 0.2% of the composition. If the content is less than 0.001%, the effects of tannins cannot be satisfied. When the content exceeds 0.2%, the taste of licorice extract will negatively affect the composition from the viewpoint of preference. The composition for oral cavity according to the present invention can be made in the form of dentifrice, for example, toothpaste, tooth powder, dentifrice, etc., mouthwash and oral cryogen. Here, ingredients often used for this purpose can also be mixed into the oral composition. For example, uranium grinding agents, including silica uranium grinding agents, such as precipitated silica, silica gel, aluminum silicate, zirconium silicate, etc., calcium hydrogen phosphate dihydrate and anhydride, calcium pyrophosphate, calcium phosphate, apatite Hydroxide, apatite fluoride, calcium-free apatite, tetrabasic calcium phosphate, octabasic calcium phosphate, calcium carbonate, aluminum hydroxide, aluminum oxide, magnesium carbonate, magnesium tribasic phosphate, insoluble magnesium metaphosphate, Insoluble calcium metaphosphate, titanium dioxide, zeolite, aluminum silicate, zirconium silicate, etc. These can be used alone or in combination. The content of the dentifrice composition ranges from 0 to 90%, preferably from 10 to 80%. Examples of humectants include glycerin, sorbitol, propylene glycol, polyethylene glycol, and the like. These can be used alone or in combination. Its content usually ranges from 10 to 80% of the composition. Examples of binders include sodium carboxymethyl cellulose, carrageenan, hydroxyethyl cellulose, sodium alginate, tragacanth, sodium polyacrylate, locust bean gum, CarbopQle ©, guar gum, montmorillonite Soil etc. These can be used alone or in combination. The content range is usually 0 to 5%. Adjustable surfactants include anionic surfactants, cations (please read the precautions on the back first, then this page) · 1! 111
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -6 - 542723 A7 B7 五、發明說明（4 ) 表面活性劑，非離子性表面活性劑等。特選實例包括月桂 基硫酸鈉’ α -鏈烯磺酸鹽，N -醯基各胺酸鹽’ 2 -烷 基一 Ν -羧甲基一 Ν~羥基乙基咪唑啉甜菜鹼，Ν -醯基 牛磺酸鹽，蔗糖脂肪酸酯，醇醯胺，聚氧代乙烯氫化蓖麻 油，聚甘油脂肪酸酯，普朗尼（Pluronic )，聚氧代乙烯山 梨糖醇酐單硬脂酸鹽等。該表面活性劑可單獨使用或合倂 使用。含量範圍通常爲〇至5%。 甜味劑之實施例包括糖精鈉，史提凡塞（stevioside ) 。史提凡（ste^a )萃出物，對位甲氧基肉桂醛，新橙皮 基二氫查耳酮，紫蘇子等。防腐劑包括，例如對位氧代苯 甲酸酯，苯甲酸鈉等。 增香劑之實施例爲經常使用於口腔用組成物中者，且 包括天然增香劑或主要的油類，例如薄荷油（peppermint oil )，薄荷油（spearmint oil )，茴香油，桉樹油，冬青 油，山扁豆油，丁子香油，百里油，鼠尾草油，檸檬油， 橘子油，琴^荷油（mint oil )，砂仁油，完妥油，紅橘油， 萊姆油’薰衣草油，迷迭香油，月桂油，春黃菊油，竟蒿 子油，馬佳油（majoram oil )，月桂樹油，檸檬草油，牛 至油’松針油，橙油，玫瑰油，茉莉油，鳶尾混凝物，無 水薄荷’無水玫瑰，橘子花等；增香劑成份，例如薄荷， 香芹酮’茴香腦，桉樹腦，水楊酸甲酯，肉桂醛，丁子香 酚’百里酚，沈香醇，醋酸里哪醇，攀烯，薄荷酮，醋酸 盖酯，蒎烯，辛基醛，檸檬醛，蒲勒酮，乙烯醋酸酐，茴 香醛等；及化合物增香劑，其包括各組成份，例如醋酸乙 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） (請先閱讀背面之注意事項再 訂---------This paper size applies to China National Standard (CNS) A4 specifications (210 X 297 mm) -6-542723 A7 B7 V. Description of the invention (4) Surfactants, non-ionic surfactants, etc. Specific examples include sodium lauryl sulfate, α-alkenesulfonate, N-fluorenyl amine salt, 2-alkyl-N-carboxymethyl-N ~ hydroxyethylimidazoline betaine, N-fluorenyl Taurate, sucrose fatty acid ester, melamine, polyoxyethylene hydrogenated castor oil, polyglycerol fatty acid ester, Pluronic, polyoxyethylene sorbitan monostearate, etc. This surfactant can be used alone or in combination. The content range is usually 0 to 5%. Examples of sweeteners include sodium saccharin, stevioside. Stefan (a) extracts, para-methoxycinnamaldehyde, neo orange peel dihydrochalcone, perilla seed, etc. Preservatives include, for example, para-oxobenzoate, sodium benzoate, and the like. Examples of flavoring agents are those often used in oral compositions, and include natural flavoring agents or major oils, such as peppermint oil, spearmint oil, fennel oil, eucalyptus oil, Holly oil, lentil oil, sesame oil, thyme oil, sage oil, lemon oil, orange oil, mint oil, ammonium oil, perfect oil, red tangerine oil, lime oil ' Lavender oil, rosemary oil, laurel oil, chamomile oil, sage oil, majoram oil, laurel oil, lemongrass oil, oregano oil 'pine needle oil, orange oil, rose oil, jasmine oil, iris Coagulation, anhydrous mint 'anhydrous rose, orange flower, etc .; flavoring ingredients such as mint, carvone's anise brain, eucalyptus brain, methyl salicylate, cinnamaldehyde, eugenol' thymol, Shen Balsamic alcohol, linalyl acetate, pannene, menthol, caprylate acetate, pinene, octyl aldehyde, citral, prolesone, ethylene acetic anhydride, anisaldehyde, etc .; and compound flavoring agents, which include components , Such as the ethyl acetate paper standard applicable to the Chinese national standard Standard (CNS) A4 (210 X 297 mm) (Please read the precautions on the back before ordering ---------
經濟部智慧財產局員工消費合作社印製 542723 A7 B7 五、發明說明（5 ) 酯，丁酸乙酯，烯丙基環己烷丙酸酯，氨茴酸甲酯，縮水 甘油酸乙基甲基苯酯，香草醛，十一烷酸內酯，己醛，乙 醇’丙醇，丁醇，異戊醇，己醇，二甲基硫化物，環待（ cyclothem )，糠醛，三甲基吡嗪，乳酸，乙酯，硫代醋酸 乙酯等，其中亦可含有前述增香劑組份及/或天然增香劑 或主要的油類，例如草苺香料，蘋果香味，香蕉香料，鳳 梨香料，葡萄香料，芒果香料，熱帶水果香料，奶油香料 ’牛奶香料，綜合水果香料等。這些增香劑可以有效含量 來單獨或合倂使用。需知增香劑並非局限於實施例中所提 及者。 其他於組成物中有用的有效成份包括氟化物，例如氟 化鈉，氟化鉀，氟化亞錫，氟化緦，單氟磷酸鈉等，可溶 之磷酸化合物，例如磷酸之鉀鹽或鈉鹽，氯羥基鋁尿囊素 ’月檜醇，維生素C，溶菌酶氯化物，甘草酸及其鹽類， 氯化鈉，川艾克米酸（tranexamicacid) ε -胺基己酸， 醋酸dl —生素酯，α —雙拜醇（α — bisabolol)，異丙 基甲基苯醇，氯化己啶鹽，十六烷基吡啶氯化物，甘菊環 ，甘草酸，銅化合物，例如，氯吡啉鈉酮化物，萄糖酸銅 等，乳酸鋁，氯化緦，硝酸鉀，小檗鹼，氧肟酸及其衍生 物，三聚磷酸鈉，沸石，異構酶，澱粉酶，甲氧基乙烯， 馬來酐共聚物，表二氫膽固醇，苯並噻安氯化物（ benzethonium chlonde )，二氫膽固醇，三氯碳醯替苯胺， 檸檬酸鋅，女貞軟化萃出物，水芹（phlellodendron)萃出 物，丁子香萃出物，迷迭香，黃岑及紅花及其混合物。 (請先閱讀背面之注意事項再 衣·1 再IPir本頁 訂---------^ 經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -8- 542723 A7 ____B7_____ 五、發明說明（6 ) 這些組成份的含量係爲有效含量且係在此技藝中常用 的範圍內而不會阻礙本發明之功效者。 本發明中含有丹寧混合有甘草精萃出物的口腔用組成 物實質上沒有任何丹寧的苦味，使用時口感很好且具高的 業價値。 實施例 本發明特別地可藉著實施例來說明，其其不能用來限 定本發明。比較實施例亦有說明到。於實施例及比較實施 例中，百分比係以重量計。於這些實施例及比較實施例中 ，苦味之評估係根據在1 0個實驗組別中進行之澀味的器 官感覺評估的結果。該評估標準顯示於表1中。 表1 (請先閱讀背面之注意事項再ΙΡτ本頁) 訂·丨 經濟部智慧財產局員工消費合作社印製 評估標準 判 斷 1 0個實驗組別中對 於澀味具負面答案 的組別數 10個實驗組別中對\ 於澀味具肯定答案 的組別數 ◎:完全沒有苦味 1〇 〇 〇：一點苦味或沒 8至9 1至2 有苦味 △:稍微有苦味 6至7 3至4 X :有相當苦味 0至5 5至1〇 -9- 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 542723 A7 五、發明說明（7 ) 於下列實施例及比較實施例中，所使用之鼠尾草卒出 物含0·3%丹寧，且所使用之迷迭香萃出物含0·2% 丹寧。Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 542723 A7 B7 V. Description of the invention (5) Ester, ethyl butyrate, allyl cyclohexanepropionate, methyl anthracene, ethyl methyl glycidate Phenyl ester, vanillin, undecanolactone, hexanal, ethanol 'propanol, butanol, isoamyl alcohol, hexanol, dimethyl sulfide, cyclothem, furfural, trimethylpyrazine , Lactic acid, ethyl ester, ethyl thioacetate, etc., which may also contain the aforementioned flavoring agent components and / or natural flavoring agents or major oils, such as strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape Spices, Mango Spices, Tropical Fruit Spices, Creamy Spices' Milk Spices, Comprehensive Fruit Spices, etc. These flavoring agents can be used alone or in combination in effective amounts. It should be noted that the flavoring agent is not limited to those mentioned in the examples. Other effective ingredients useful in the composition include fluorides, such as sodium fluoride, potassium fluoride, stannous fluoride, rhenium fluoride, sodium monofluorophosphate, etc., soluble phosphate compounds, such as potassium or sodium phosphate Salt, aluminum chlorohydroxyallantoin's lunitol, vitamin C, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, tranexamicacid ε-aminocaproic acid, dl acetate Biotin esters, α-bisabolol, isopropylmethyl benzyl alcohol, hexamidine chloride salt, cetylpyridine chloride, chamomile ring, glycyrrhizic acid, copper compounds, for example, clopyridine Sodium ketone, copper gluconate, etc., aluminum lactate, europium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, isomerase, amylase, methoxyethylene , Maleic anhydride copolymer, epidihydrocholesterol, benzethonium chlonde, dihydrocholesterol, trichlorocarbamidine, zinc citrate, softening extract of Ligustrum lucidum, phlellodendron Extract, gerbera extract, rosemary, yellow censum and safflower mixture. (Please read the precautions on the back first, and then re-print IPir on this page --------- ^ Printed by the Intellectual Property Bureau Staff Consumer Cooperatives of the Ministry of Economy This paper is printed in accordance with China National Standard (CNS) A4 specifications ( 210 X 297 mm) -8- 542723 A7 ____B7_____ 5. Description of the invention (6) The content of these components is effective content and is within the range commonly used in this technique without hindering the efficacy of the present invention. The present invention The oral composition containing tannin mixed with licorice extract does not substantially have any bitterness of tannin, and has a good mouthfeel and high commercial value when used. Examples The present invention can be specifically explained by way of examples. It can not be used to limit the present invention. The comparative examples are also explained. In the examples and comparative examples, the percentages are based on weight. In these examples and comparative examples, the bitterness evaluation is based on 1 Results of the astringent organoleptic evaluation performed in 0 experimental groups. The evaluation criteria are shown in Table 1. Table 1 (Please read the precautions on the back before Ipτ page) Eliminate Cooperatives printed evaluation criteria to judge the number of groups with negative answers to astringency in 10 experimental groups. The number of groups with positive answers to astringent in 10 experimental groups: No bitterness at all. : A little bitter taste or no 8 to 9 1 to 2 bitter taste △: Slight bitter taste 6 to 7 3 to 4 X: quite bitter taste 0 to 5 5 to 1-10-9- This paper size applies Chinese National Standard (CNS) A4 Specifications (210 X 297 mm) 542723 A7 V. Description of the invention (7) In the following examples and comparative examples, the sage extract used contained 0.3% tannin, and the rosemary used Fragrant extract contains 0.2% tannin.
經濟部智慧財產局員工消費合作社印製 C實施例1及比較實施例1、2〕牙膏 組成份（％ ) 比較實施例 實施例 1 2 1 草萃出物 0.05 0 . 0 5 至ϋ精萃出物 0 . 1 矽酸酐 2〇 2 0 2 0 甘油 3 5 3 5 3 5 黃蓍膠 0 . 6 0 . 6 0 . 6 复名葉 0.2 0 . 2 〇.2 月桂基硫酸鈉 1 . 5 1 . 5 1.5 糖精鈉 一 0 . 1 0 . 1 0 . 1 增香劑 1 . 5 1 . 5 1 . 5 純水 平衡 平衡 平衡 全部 1〇0 10 0 1〇0 苦味 ◎ X ◎ 由表2之結果顯示比較實施例1之牙膏（不含任何鼠 尾草萃出物）不具苦味。而當鼠尾草萃出物配用到組成物 中時變得有苦味（比較實施例2 )。當如實施例1中所示 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -10- (請先閱讀背面之注意事項再本頁) :再 ------訂.-------- 542723 A7 _B7_ 五、發明說明（8 ) 再配用甘草精萃出物時，苦味降到最低，且口感顯著改進 (請先閱讀背面之注意事項再本頁) 再士 I=口- 1Example 1 and Comparative Examples 1, 2 printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs, toothpaste composition (%) Comparative Example Example 1 2 1 Grass extract 0.05 0. 05 to ϋ extract Substance 0.1 Silicic anhydride 20202 0 Glycerin 3 5 3 5 3 5 tragacanth 0.60 0.62 0.6 Multiple leaves 0.2 0.2. 2 Sodium lauryl sulfate 1.5 1. 5 1.5 Saccharin Sodium-0.1. 1. 1. 1. 1 Flavoring agent 1. 5 1. 5 1. 5 Pure water balance balance balance all 1 0 0 0 0 0 1 0 Bitterness ◎ X ◎ The results shown in Table 2 The toothpaste of Comparative Example 1 (without any sage extract) was not bitter. When the sage extract was added to the composition, it became bitter (Comparative Example 2). When as shown in Example 1, this paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -10- (Please read the precautions on the back before this page): Then ------ Order. -------- 542723 A7 _B7_ V. Description of the invention (8) When the licorice extract is used, the bitterness is reduced to a minimum and the taste is significantly improved (please read the precautions on the back and then this page) ) Farewell I = Mouth-1
經濟部智慧財產局員工消費合作社印製 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 542723 7 7 A β 五、發明說明（9 )〔實施例2至1 6〕牙膏 經濟部智慧財產局員工消費合作社印製 組成份(％) 實 施 例 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 鼠尾草萃出物 0.01 0.05 0.1 0.06 0,04 0.02 0.1 0.01 迷迭香萃出物 0.05 0.09 0.1 0.2 0.8 0.15 0.05 0.06 0.05 甘草精萃出物 0.05 0.1 0.02 0.06 0.08 0.1 0.09 0.02 0.03 0.04 0.08 0.07 0.09 0.1 0.01 液態石腊 1 7 1.5 2 8 5 2 凡士林 0.5 0.8 1.5 1.2 角鯊烯 3 1.5 0.5 角鯊烯 1.5 焦碳酸鈉 2 3 1 0.5 2 焦磷酸鉀 3 5 0.5 1.5 5 三聚磷酸鈉 2 1 0.5 0.8 1 乳酸鋁 1.2 1.2 尿囊素 0.5 0.4 1.2 0.2 植酸 0.8 0.5 酒石酸 0.5 0.8 5 ΐ夕酉干 10 20 15 10 10 15 5 磷酸氫鈣 45 40 35 45 氫氧化鋁 45 40 35 碳酸鈣 40 35 丙烯乙二醇 3 2 3 5 10 2 3 4 3 5 2,5 3 5 3 4 甘油（（85%) 25 23 15 58 20 35 25 25 20 山梨糖醇(70%) 30 50 30 40 30 40 30 羧酸甲基纖維 1.2 1 1.2 1.5 0.6 1.2 1.5 1 素 黃蓍膠 0.8 1.2 0.6 0.9 0.6 0.6 1 角叉菜膠 0.4 0.5 0.2 0.3 0.8 0.3 0.5 0.6 0.2 月桂醯基乳酸 0.3 0.4 0.1 0.2 0.4 0.1 0.2 鈉 月桂基硫酸鈉 1 1.5 1.2 0.5 1.2 1.5 1 1.8 2 0.5 1.2 1.5 2 1.5 1.5 川艾克米酸 0.05 0.05 0.05 0.05 0.05 ε-胺基己酸 0.05 0.05 0.05 甘草酸二鉀 0,05 0.05 氟化鈉 0.21 0.21 0.21 0.21 0.21 單氟磷酸鈉 0.76 0.76 0.76 0.76 栝樓素 0.05 0.05 0.05 糖精鈉 0.1 0.2 0.1 0.3 0.4 0.2 0.3 0.5 0.15 0.25 0.2 0.3 0.25 0.4 0.15 增香劑 1.2 1 1.3 0.6 1 1.2 1 0.6 0.8 1.5 1 1.2 1.5 1.3 0,8 純水 平衡 平衡 平衡 平衡 平衡 平 平衡 平 平 平 平 平 平 平 平 衡 衡 衡 衡 衡 衡 衡 衡 衡 全部 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 苦味評估 〇 ◎ 〇 ◎ 〇 〇 ◎ ◎ 〇 ◎ ◎ 〇 ◎ 〇 〇 (請先閱讀背面之注意事項再本頁) Μ 再女 -m emmet Mail m n n ^ a i n i·— n =口Printed by the Employees' Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs. The paper size is applicable to the Chinese National Standard (CNS) A4 (210 X 297 mm) 542723 7 7 A β 5. Description of the invention (9) [Examples 2 to 16] Toothpaste Printed Composition (%) of the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs Example 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Sage extract 0.01 0.05 0.1 0.06 0,04 0.02 0.1 0.01 Rosemary Fragrant extract 0.05 0.09 0.1 0.2 0.8 0.15 0.05 0.06 0.05 Licorice extract 0.05 0.1 0.02 0.06 0.08 0.1 0.09 0.02 0.03 0.04 0.08 0.07 0.09 0.1 0.01 Liquid paraffin 1 7 1.5 2 8 5 2 Vaseline 0.5 0.8 1.5 1.2 Angle shark Ene 3 1.5 0.5 squalene 1.5 sodium pyrocarbonate 2 3 1 0.5 2 potassium pyrophosphate 3 5 0.5 1.5 5 sodium tripolyphosphate 2 1 0.5 0.8 1 aluminum lactate 1.2 1.2 allantoin 0.5 0.4 1.2 0.2 phytic acid 0.8 0.5 tartaric acid 0.5 0.8 5 ΐxi ΐ dried 10 20 15 10 10 15 5 calcium hydrogen phosphate 45 40 35 45 Aluminum hydroxide 45 40 35 Calcium carbonate 40 35 Propylene glycol 3 2 3 5 10 2 3 4 3 5 2, 5 3 5 3 4 Glycerin ((85%) 25 23 15 58 20 35 25 25 20 Yamanashi Sugar alcohol (70%) 30 50 30 40 30 40 30 Carboxymethyl fiber 1.2 1 1.2 1.5 0.6 1.2 1.5 1 Carrageenan 0.8 1.2 0.6 0.9 0.6 0.6 1 Carrageenan 0.4 0.5 0.2 0.3 0.8 0.3 0.5 0.6 0.2 Lauryl lactate 0.3 0.4 0.1 0.2 0.4 0.1 0.2 Sodium lauryl sulfate 1 1.5 1.2 0.5 1.2 1.5 1 1.8 2 0.5 1.2 1.5 2 1.5 1.5 Chuanximic acid 0.05 0.05 0.05 0.05 0.05 ε-Aminocaproic acid 0.05 0.05 0.05 Dipotassium glycyrrhizinate 0,05 0.05 Sodium fluoride 0.21 0.21 0.21 0.21 0.21 Sodium monofluorophosphate 0.76 0.76 0.76 0.76 Taurol 0.05 0.05 0.05 Saccharin sodium 0.1 0.2 0.1 0.3 0.4 0.2 0.3 0.5 0.15 0.25 0.2 0.3 0.25 0.4 0.15 Flavoring agent 1.2 1 1.3 0.6 1 1.2 1 0.6 0.8 1.5 1 1.2 1.5 1.3 0,8 Pure water balance Balance balance Balance balance Balanced Balanced Balanced Balanced Balanced Balance Balanced Balance Balanced Balance Balanced Balance Balanced Balance All Balanced 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 100 Bitterness evaluation ○ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ◎ ○ 〇 (please first (Please read the notes on the back, and then this page) Ｍ 再 女 -m emmet Mail mnn ^ aini · — n = 口
線 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 542723 A7 B7Line This paper size is applicable to China National Standard (CNS) A4 (210 X 297 mm) 542723 A7 B7
五、發明說明（1Q 〔實施例1 7〕牙粉（苦味評估 :◎) 甘草精萃出物 0 . 〇5 鼠尾草萃出物 〇· 〇1 焦磷酸鈉 3 丁基對苯 〇· 0 2 碳酸鈣 7 0 山梨糖醇 2 甘油 8 糖精鈉 0 . 〇8 月桂基硫酸鈉 2 增香齊ij 1 純水 平衡 全部 0 0 . 0 % (請先閱讀背面之注意事項再本頁) 經濟部智慧財產局員工消費合作社印製 〔實施例1 8〕漱口水（苦味評估：〇） 甘草精萃出物 〇 迷迭香萃出物 〇 焦磷酸鈉 5 乙醇 10. 甘油 8.0 糖精鈉 0.1 聚乙烯氫化箆麻油 1 .〇 苯甲酸鈉 0.3 增香劑 0.5 0 2% 〇V. Description of the invention (1Q [Example 17] Tooth powder (bitterness evaluation: ◎) Licorice extract 0.05 sage extract 0.0 · 1 sodium pyrophosphate 3 butyl-p-benzene 0.02 Calcium Carbonate 7 0 Sorbitol 2 Glycerin 8 Saccharin Sodium 0. 008 Sodium Lauryl Sulfate 2 Flavored Qi ij 1 Pure Water Balance All 0 0. 0% (Please read the precautions on the back before this page) Wisdom of the Ministry of Economy Printed by the Consumer Cooperative of the Property Bureau [Example 18] Mouthwash (bitterness evaluation: 0) Licorice extract 0 Rosemary extract 0 Sodium pyrophosphate 5 Ethanol 10. Glycerin 8.0 Saccharin sodium 0.1 Polyvinyl hydride Sesame oil 1.0 Sodium benzoate 0.3 Flavoring agent 0.5 0 2% 〇
—訂---------Λ 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -13- 542723 A7 B7 五、發明說明（11 純水_ 平衡 全部 〇.0 % 〔實 甘草 鼠尾 乳酸 乙醇 山梨 糖精 普朗 苯甲 檸檬 增香 純水 施例1 9漱口水（苦味評估 精萃出物 草萃出物 鋁 糖醇 鈉 尾 F 1 2 7 酸鈉 酸鈉 劑 • @ ) 0.05% 0 . 1 0 . 5 5 ·〇 10.0 0 . 1 2 . 0 0 . 3 〇.5 〇.4 平衡 (請先閱讀背面之注意事項再ιρι本頁) 再 訂---------^ 全部 0 0 . 0 % 實施例2 0〕漱口水（苦味評估：◎)—Order --------- Λ This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) -13- 542723 A7 B7 V. Description of the invention (11 pure water _ balance all 〇. 0% [Liquorice sage tail lactic acid ethanol sorbose saccharin plum benzoin lemon flavored pure water Example 1 9 Mouthwash (bitterness evaluation extract grass extract sodium aluminol tail F 1 2 7 sodium sodium • @) 0.05% 0. 1 0. 5 5 · 〇10.0 0. 1 2. 0 0. 3 0. 5 0. 4 Balance (please read the precautions on the back first and then this page) Re-order ----- ---- ^ All 0 0. 0% Example 2 0] Mouthwash (bitterness evaluation: ◎)
經濟部智慧財產局員工消費合作社印製 甘草精萃出物 迷迭香萃出物 尿囊素 乙醇 甘油 糖精鈉 〇 〇 〇 1 % 0 8 〇 〇 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） -14 - 542723 A7 B7 五、發明說明（12 ) 聚氧化乙烯氫化Μ麻油 苯甲酸鈉 增香齊ij 純水 _ 1 . 2 〇.3 Ο . 5 平衡_ 全部 1〇0 ·〇％ 〔實施例2 1〕口腔冷凍劑（苦味評估：◎) 經濟部智慧財產局員工消費合作社印製 甘草精萃出物 〇 〇 8 % 鼠尾草萃出物 〇 • 〇 6 迷迭香萃出物 0 • 0 2 焦磷酸鈉 2 • 〇 乙醇 3 0 • 〇 甘油 1 5 〇 糖精鈉 〇 3 聚氧代乙烯氫化篦麻油 3 * 〇 增香齊[J 1 * 〇 純水 平衡 全部 1 0 〇 .0 % 〔實施例2 2〕潔牙劑 (苦味評估： ◎ ) 磷酸二元鈉 4 5 % 丙烯乙二醇 3 山梨糖醇 1 6 甘油 1 5 -15- --------訂·-------i (請先閱讀背面之注意事項再本頁) 太Printed by licorice extract, rosemary extract, allantoin, ethanol, glycerol and saccharin sodium from the Intellectual Property Bureau of the Intellectual Property Bureau of the Ministry of Economic Affairs, this paper standard applies to China National Standard (CNS) A4 ( 210 X 297 mm) -14-542723 A7 B7 V. Description of the invention (12) Polyethylene oxide hydrogenated M sesame oil sodium benzoate flavored Qi ij pure water _ 1. 2 〇.3 〇 .5 balance _ all 1 0 · 〇% [Example 2 1] Oral refrigerant (bitterness evaluation: ◎) Liquorice extract printed by the Consumer Cooperative of Intellectual Property Bureau of the Ministry of Economic Affairs 〇8% sage extract 〇 • 〇6 rosemary extract Output 0 • 0 2 Sodium pyrophosphate 2 • 〇 Ethanol 3 0 • 〇 Glycerin 15 〇 Sodium saccharin 〇 3 Polyoxyethylene hydrogenated ramie oil 3 * 〇Fragrance Qi [J 1 * 〇 pure water balance all 1 0 〇 .0% [Example 2 2] Dentifrice (bitterness evaluation: ◎) Dibasic sodium phosphate 4 5% Propylene glycol 3 Sorbitol 1 6 Glycerol 1 5 -15 --------- Order · ------- i (Please read the precautions on the back before this page) too
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 542723 A7 B7 經濟部智慧財產局員工消費合作社印製 五、發明說明（13 ) 黃蓍膠 聚丙烯酸鈉 羧酸甲基纖維素鈉 苯甲酸鈉 月桂基硫酸鈉 糖精鈉 對位苯 增香劑A (與一說明如下之組成物） 栝樓素 甘草亭酸 川艾克米酸 水芹萃出物 乙糖醇 肉豆蔻醯二乙醇醯胺 聚乙烯基吡咯烷酮 蘆薈萃出物 百里萃出物· 女貞丘魯布（acutilobum ) 野玫瑰萃出物 山金車萃出物 茴香萃出物 兒茶萃出物 春黃菊萃出物 〇 〇 〇 〇 〇 0 (請先閱讀背面之注意事項再ιρι本頁) 〇 〇 〇 〇 〇 〇 〇 〇 〇 萃出物〇 〇 〇 〇 〇 〇 0 〇 〇 0 0 2 0 0 3 〇0 1 0 0 2 〇〇1 0 0 1 0 0 1 〇〇1 — 訂---------iaThis paper size applies to China National Standard (CNS) A4 (210 X 297 mm) 542723 A7 B7 Printed by the Consumer Cooperatives of the Intellectual Property Bureau of the Ministry of Economic Affairs 5. Description of the invention (13) Xanthan gum sodium polyacrylate carboxylic acid methyl fiber Sodium Benzoate Sodium Lauryl Sulfate Sodium Saccharin Sodium Paraben Flavoring Agent A (with a composition as described below) Glycyrrhizin glycyrrhizin acid Chuanxi Acemic acid Cress extract Ethyl alcohol Myristic Diethanol Phenylvinylpyrrolidone aloe extract thyme extract · Ligustrum lucidum (acutilobum) wild rose extract arnica extract fennel extract catechin extract chamomile extract. 〇〇〇〇〇0 (Please read the precautions on the back before tiling this page) 〇〇〇〇〇〇〇〇〇 Extract 〇〇〇〇〇〇〇 〇 〇 0 0 2 0 0 3 〇 0 1 0 0 2 〇〇1 0 0 1 0 0 1 〇〇1 — subscription ----- ia
本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） ^16- 542723 A7 B7 五、發明說明（14 搌牛兒苗 0 . 〇 〇 1 茶葉萃出物 〇. 〇 〇 1 蛇麻萃出物 〇 . 〇 〇 1 粟子萃出物 〇 . 〇 〇 1 蜂花萃出物 〇 . 〇 〇 1 桃子萃出物 〇 . 〇 〇 1 草莓虎耳萃出物 〇· 〇 〇 1 迷迭香萃出物 0 · 1 鼠尾草萃出物 〇 . 1 春黃菊萃出物 0 . 1 黃岑之乾萃出物 〇. 1 甘草精萃出物 〇 . 1 藍色1號（染料） 〇· 〇 〇 〇 1 綠色3號（染料） 〇 . 〇 〇 〇 3 水 平衡 全部 10 〇 〇 % (請先閱讀背面之注意事項再 i 再ml本頁This paper size applies the Chinese National Standard (CNS) A4 specification (210 X 297 mm) ^ 16- 542723 A7 B7 V. Description of the invention (14 Yak seedlings 0. 〇01 tea extract 〇. 〇〇1 snake Hemp extract 〇〇〇〇1 Millet extract 〇〇〇〇1 Bee extract 〇〇 〇〇1 Peach extract 〇〇〇〇1 Strawberry tiger ear extract 〇 〇〇1 Rosemary Fragrant extract 0. 1 sage extract 0.1. Chamomile extract 0.1 dry extract of Huangcen 0.1. Licorice extract 0.1 blue 1 (dye) 〇 · 〇 〇〇1 Green No. 3 (dye) 〇 〇〇〇3 water balance of all 100% (please read the precautions on the back before i again on this page
------訂--------I------ Order -------- I
經濟部智慧財產局員工消費合作社印製 增香劑A 薄荷醇 薄荷油（Peppermint iol) 薄荷油（Spearmint oil) 曰本薄荷油 桉樹油 冬青油 4 7 .0 % 1.0 .0 •〇 •〇 本紙張尺度適用中國國家標準（CNS)A4規格（210 X 297公釐） 542723 A7 B7 五、發明說明（15 ) 經濟部智慧財產局員工消費合作社印製 香芹酮 2 . 〇 茴香腦 1〇 .〇 茴香油 1 . 〇 蘋果增香劑 3 . 〇 草莓香料 2 . 〇 百里油 〇· 2 小豆蔻油 〇· 2 丁子香油 〇. 2 熟羊皮油 0 · 2 山扁豆油 0 . 5 橘子油 0 · 2 檸檬油 0 · 2 萊姆油 0 . 2 芫荽油 〇· 2 酒礦油 0 · 2 玫瑰油 0 . 1 鳶尾混凝物 〇. 1 紫羅蘭葉油 〇. 1 熏衣草油 〇· 1 綜合水果增香劑 3 . 〇 乙醇 平衡 全部 1 0〇_ 0 % (請先閱讀背面之注意事項再ΙΡϋ本頁)Printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs A flavoring agent A Peppermint iol Peppermint oil Japanese peppermint oil eucalyptus holly oil 4 7.0% 1.0 .0 • 〇 • 〇Paper The scale is applicable to the Chinese National Standard (CNS) A4 specification (210 X 297 mm) 542723 A7 B7 V. Description of the invention (15) Carvone printed by the Consumer Cooperative of the Intellectual Property Bureau of the Ministry of Economic Affairs 2. fennel brain 10. fennel Oil 1. Apple flavoring agent 3. Strawberry flavor 2.0 Berry oil 0.2 Cardamom oil 0.2 Dried sesame oil 0.2 Cooked sheepskin oil 0.2 Mangosteen oil 0.5 Orange oil 0.2 Lemon oil 0.2 Lime oil 0.2 Emu oil 0.2 Liquor mineral oil 0.2 Rose oil 0.1 Iris coagulate 0.1 Violet leaf oil 0.1 Lavender oil 0.1 Comprehensive fruit Fragrance 3. 〇 Ethanol balance of all 100% 0% (please read the precautions on the back first and then this page)
訂· _Order · _
本紙張尺度適用中國國家標準（CNS)A4規格（210 x 297公釐） -18-This paper size applies to China National Standard (CNS) A4 (210 x 297 mm) -18-
Claims (1)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP34718497 | 1997-12-02 | ||
| JP25463398A JP3570482B2 (en) | 1997-12-02 | 1998-08-25 | Dentifrice composition and method for suppressing bitterness |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW542723B true TW542723B (en) | 2003-07-21 |
Family
ID=26541767
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW87119495A TW542723B (en) | 1997-12-02 | 1998-11-24 | Oral composition |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JP3570482B2 (en) |
| TW (1) | TW542723B (en) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4754671B2 (en) * | 1999-11-30 | 2011-08-24 | 花王株式会社 | Cosmetics |
| JP4261744B2 (en) * | 2000-07-05 | 2009-04-30 | 小林製薬株式会社 | Oral composition |
| WO2003035092A1 (en) * | 2001-10-26 | 2003-05-01 | Angiolab Inc. | Composition containing horse chestnut extract for anti-angiogenic and matrix metalloproteinase inhibitory activity |
| JP2003160459A (en) * | 2001-11-22 | 2003-06-03 | Kansai Koso Kk | Methionase activity inhibitor and composition for oral cavity |
| JP4499382B2 (en) * | 2003-08-21 | 2010-07-07 | 日本メナード化粧品株式会社 | Lipolysis accelerator |
| GB0501654D0 (en) * | 2005-01-26 | 2005-03-02 | Veritron Ltd | Stabilised plant extract |
| JP2006282562A (en) * | 2005-03-31 | 2006-10-19 | Kobayashi Pharmaceut Co Ltd | Agent for periodontosis compounded with aesculus hippocastanum l. extract component |
| JP5963383B2 (en) * | 2005-06-06 | 2016-08-03 | 株式会社明治 | Oral care composition |
| KR101180267B1 (en) * | 2010-05-06 | 2012-09-06 | 이차용 | Oral spray composition containing Chamomile |
| CN106474051B (en) | 2011-03-21 | 2022-07-08 | 博任达生化科技（上海）有限公司 | Reverse temperature-sensitive reversible hydrogel composition |
| KR20180133220A (en) * | 2017-06-05 | 2018-12-13 | 라이온 가부시키가이샤 | Oral composition |
| JP2018203714A (en) * | 2017-06-05 | 2018-12-27 | ライオン株式会社 | Oral composition |
| WO2020186258A1 (en) * | 2019-03-14 | 2020-09-17 | IntraMont Technologies, Inc. | Preparations for the prevention of illnesses acquired via the oral cavity and pharynx |
| JP7031253B2 (en) * | 2017-11-29 | 2022-03-08 | ライオン株式会社 | Toothpaste composition |
| CN111603415B (en) * | 2019-02-22 | 2023-12-19 | 好维股份有限公司 | Oral care compositions comprising hops extract and uses thereof |
-
1998
- 1998-08-25 JP JP25463398A patent/JP3570482B2/en not_active Expired - Fee Related
- 1998-11-24 TW TW87119495A patent/TW542723B/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JPH11222419A (en) | 1999-08-17 |
| JP3570482B2 (en) | 2004-09-29 |
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| GD4A | Issue of patent certificate for granted invention patent | ||
| MM4A | Annulment or lapse of patent due to non-payment of fees |