TW526206B - Reshaped human antibody to human medulloblastoma cells - Google Patents
Reshaped human antibody to human medulloblastoma cells Download PDFInfo
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- TW526206B TW526206B TW083110754A TW83110754A TW526206B TW 526206 B TW526206 B TW 526206B TW 083110754 A TW083110754 A TW 083110754A TW 83110754 A TW83110754 A TW 83110754A TW 526206 B TW526206 B TW 526206B
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- 208000000172 Medulloblastoma Diseases 0.000 title abstract 5
- 150000001413 amino acids Chemical group 0.000 claims description 125
- 238000011049 filling Methods 0.000 claims description 71
- 210000002706 plastid Anatomy 0.000 claims description 69
- 210000001185 bone marrow Anatomy 0.000 claims description 55
- 201000000053 blastoma Diseases 0.000 claims description 49
- 201000008184 embryoma Diseases 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 41
- 108010089804 glycyl-threonine Proteins 0.000 claims description 36
- 239000013604 expression vector Substances 0.000 claims description 34
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- DHBKYZYFEXXUAK-ONGXEEELSA-N Ala-Phe-Gly Chemical compound OC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)C)CC1=CC=CC=C1 DHBKYZYFEXXUAK-ONGXEEELSA-N 0.000 claims description 19
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- SOEGEPHNZOISMT-BYPYZUCNSA-N Gly-Ser-Gly Chemical compound NCC(=O)N[C@@H](CO)C(=O)NCC(O)=O SOEGEPHNZOISMT-BYPYZUCNSA-N 0.000 claims description 19
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- 108010063718 gamma-glutamylaspartic acid Proteins 0.000 claims description 4
- XKUKSGPZAADMRA-UHFFFAOYSA-N glycyl-glycyl-glycine Chemical compound NCC(=O)NCC(=O)NCC(O)=O XKUKSGPZAADMRA-UHFFFAOYSA-N 0.000 claims description 4
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3053—Skin, nerves, brain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Cell Biology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP29107893 | 1993-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW526206B true TW526206B (en) | 2003-04-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW083110754A TW526206B (en) | 1993-11-19 | 1994-11-18 | Reshaped human antibody to human medulloblastoma cells |
Country Status (5)
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|---|---|
| US (3) | US6214973B1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP0729976A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU7949394A (cg-RX-API-DMAC7.html) |
| TW (1) | TW526206B (cg-RX-API-DMAC7.html) |
| WO (1) | WO1995014041A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4134497A (en) * | 1996-09-03 | 1998-03-26 | Chugai Seiyaku Kabushiki Kaisha | Anti-integrin alpha3 antibody complexes |
| DK2208784T3 (da) * | 2001-06-22 | 2013-03-18 | Chugai Pharmaceutical Co Ltd | Celleproliferationsinhibitorer indeholdende anti-glypican-3-antistof |
| EP1425390B1 (en) * | 2001-08-13 | 2012-02-01 | University of Florida Research Foundation, Inc. | Materials and methods to promote repair of nerve tissue |
| KR101591223B1 (ko) * | 2005-12-12 | 2016-02-04 | 에이씨 이뮨 에스.에이. | 치료적 특성을 갖는 베타 1-42 특이적인 단일클론성 항체 |
| SG173385A1 (en) * | 2006-07-14 | 2011-08-29 | Ac Immune S A Ch | Humanized antibody against amyloid beta |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
| US20090155249A1 (en) * | 2007-06-12 | 2009-06-18 | Ac Immune S.A. | Humanized antibody igg1 |
| EP2650308A3 (en) * | 2007-10-05 | 2014-11-12 | Genentech, Inc. | Use of anti-amyloid beta antibody in ocular diseases |
| NZ585110A (en) * | 2007-10-05 | 2012-09-28 | Genentech Inc | Method and compositions for diagnosis and treatment of amyloidosis |
| PL2238166T3 (pl) | 2007-10-05 | 2014-07-31 | Genentech Inc | Zastosowanie przeciwciała anty-Beta amyloidowego w chorobach oczu |
| EP2248826B1 (en) | 2008-01-10 | 2013-06-12 | Shionogi&Co., Ltd. | Antibody directed against pcrv |
| MX341369B (es) | 2010-07-30 | 2016-08-17 | Genentech Inc * | Anticuerpo anti-beta-amiloide humanizado seguro y funcional. |
| CA2937034A1 (en) | 2014-02-03 | 2015-08-06 | National Cancer Center | Anti-tissue factor monoclonal antibody |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| AU2019277546A1 (en) | 2018-05-31 | 2020-12-17 | Shionogi & Co., Ltd. | Nav1.7 monoclonal antibody |
| TW202039575A (zh) | 2018-12-27 | 2020-11-01 | 日商鹽野義製藥股份有限公司 | 新穎之抗ｃｃｒ８抗體 |
| JPWO2022004760A1 (cg-RX-API-DMAC7.html) | 2020-06-30 | 2022-01-06 | ||
| MX2024004393A (es) | 2021-11-01 | 2024-04-30 | Shionogi & Co | Nuevo anticuerpo monoclonal nav1.7. |
| EP4534672A1 (en) | 2022-06-03 | 2025-04-09 | Shionogi & Co., Ltd | Antibody that binds to cannabinoid type 1 receptors |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6147500A (ja) * | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| US5132405A (en) * | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL162181A (en) | 1988-12-28 | 2006-04-10 | Pdl Biopharma Inc | A method of producing humanized immunoglubulin, and polynucleotides encoding the same |
| GB8928874D0 (en) * | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| HU218140B (hu) * | 1991-04-25 | 2000-06-28 | Chugai Seiyaku Kabushiki Kaisha | Humán interleukin-6-receptorral szembeni átalakított humán antitest |
| CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
| DE4225853A1 (de) * | 1992-08-05 | 1994-02-10 | Behringwerke Ag | Granulozytenbindende Antikörperfragmente, ihre Herstellung und Verwendung |
-
1994
- 1994-10-19 AU AU79493/94A patent/AU7949394A/en not_active Abandoned
- 1994-10-19 WO PCT/JP1994/001763 patent/WO1995014041A1/ja not_active Ceased
- 1994-10-19 EP EP94930341A patent/EP0729976A1/en not_active Withdrawn
- 1994-10-19 US US08/646,265 patent/US6214973B1/en not_active Expired - Lifetime
- 1994-11-18 TW TW083110754A patent/TW526206B/zh active
-
2000
- 2000-12-29 US US09/749,873 patent/US20030023045A1/en not_active Abandoned
-
2004
- 2004-05-06 US US10/839,799 patent/US7563599B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| EP0729976A4 (cg-RX-API-DMAC7.html) | 1996-10-16 |
| US20050249726A1 (en) | 2005-11-10 |
| US7563599B2 (en) | 2009-07-21 |
| AU7949394A (en) | 1995-06-06 |
| US6214973B1 (en) | 2001-04-10 |
| US20030023045A1 (en) | 2003-01-30 |
| EP0729976A1 (en) | 1996-09-04 |
| WO1995014041A1 (en) | 1995-05-26 |
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