TW448174B - 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection - Google Patents

9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection Download PDF

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Publication number
TW448174B
TW448174B TW087109086A TW87109086A TW448174B TW 448174 B TW448174 B TW 448174B TW 087109086 A TW087109086 A TW 087109086A TW 87109086 A TW87109086 A TW 87109086A TW 448174 B TW448174 B TW 448174B
Authority
TW
Taiwan
Prior art keywords
deoxy
methyl
hydrazine
carbamate
oxolactide
Prior art date
Application number
TW087109086A
Other languages
English (en)
Chinese (zh)
Inventor
Yong-Jin Wu
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Application granted granted Critical
Publication of TW448174B publication Critical patent/TW448174B/zh

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
TW087109086A 1997-06-11 1998-06-08 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection TW448174B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4934997P 1997-06-11 1997-06-11

Publications (1)

Publication Number Publication Date
TW448174B true TW448174B (en) 2001-08-01

Family

ID=21959341

Family Applications (1)

Application Number Title Priority Date Filing Date
TW087109086A TW448174B (en) 1997-06-11 1998-06-08 9-oxime erythromycin derivatives, the preparation process thereof and pharmaceutical composition for treating bacterial infection or protozoa infection

Country Status (31)

Country Link
EP (1) EP0988308A1 (no)
JP (1) JP2000513026A (no)
KR (1) KR20010013660A (no)
CN (1) CN1259135A (no)
AP (1) AP9801253A0 (no)
AR (1) AR012244A1 (no)
AU (1) AU7226798A (no)
BG (1) BG103947A (no)
BR (1) BR9810021A (no)
CA (1) CA2293335A1 (no)
CO (1) CO4940506A1 (no)
CZ (1) CZ9904388A3 (no)
EA (1) EA199901016A1 (no)
GT (1) GT199800074A (no)
HN (1) HN1998000073A (no)
HR (1) HRP980316A2 (no)
HU (1) HUP0002252A3 (no)
ID (1) ID24529A (no)
IL (1) IL132767A0 (no)
IS (1) IS5251A (no)
MA (1) MA26505A1 (no)
NO (1) NO996108L (no)
OA (1) OA11225A (no)
PA (1) PA8451801A1 (no)
PE (1) PE79899A1 (no)
PL (1) PL337606A1 (no)
TN (1) TNSN98083A1 (no)
TR (1) TR199902995T2 (no)
TW (1) TW448174B (no)
WO (1) WO1998056800A1 (no)
ZA (1) ZA985018B (no)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HN1998000159A (es) * 1997-10-29 1999-02-09 Monsanto Co Derivados de 9- amino - 3 ceto eritromicina
ATE298761T1 (de) 1998-09-22 2005-07-15 Pfizer Prod Inc Carbamat- und carbazatketolidantibiotika
FR2786188B1 (fr) * 1998-11-24 2002-10-31 Hoechst Marion Roussel Inc Nouveaux derives de l'erythromycine, leur procede de preparation et leur applicaion comme medicaments
US6258785B1 (en) 1998-12-02 2001-07-10 Pfizer Inc. Crystalline 9-E-(O-methyl)oxime of 11, 12-dideoxy-3-de(2,6-dideoxy-3-C-methyl-3-O-methyl-α-L-ribohexopyranosyloxy)-6-O-methyl-12,11-(iminocarbonyl-(2-(3-(4-(3-pyridinyl)1H-imadazol-1-yl)propyl)hydrazono))-3-oxoerythromycin
EP1298138B1 (en) * 1998-12-10 2006-11-02 Pfizer Products Inc. Carbamate and Carbazate Ketolide Antibiotics
US6284732B1 (en) * 1998-12-18 2001-09-04 Bio-Rad Laboratories, Inc. Peptides and peptide analogues designed from HFE protein and their uses in the treatment of iron overload diseases
ATE340183T1 (de) * 1999-04-16 2006-10-15 Kosan Biosciences Inc Antiinfektiöse makrolidderivate
HUP0201516A3 (en) 1999-05-24 2003-03-28 Pfizer Prod Inc 13-methyl-erythromycin derivatives, process for their preparation and pharmaceutical compositions containing them
WO2000075156A1 (en) * 1999-06-07 2000-12-14 Abbott Laboratories 6-o-carbamate ketolide derivatives
ID27331A (id) * 1999-09-29 2001-03-29 Pfizer Prod Inc Pembuatan antibiotik-antibiotik ketolida karbamat
EP1439186A3 (en) * 1999-12-29 2004-11-03 Pfizer Products Inc. Intermediates for novel antibacterial and prokinetic macrolides
EP1114826A3 (en) * 1999-12-29 2001-10-31 Pfizer Products Inc. Novel antibacterial and prokinetic macrolides
US6946446B2 (en) 2000-02-24 2005-09-20 Abbott Laboratories Anti-infective agents useful against multidrug-resistant strains of bacteria
US6403776B1 (en) 2000-07-05 2002-06-11 Pfizer Inc. Synthesis of carbamate ketolide antibiotics
WO2003090761A1 (en) * 2002-04-25 2003-11-06 Abbott Laboratories 9-oxime macrolide antibacterials
US7091196B2 (en) 2002-09-26 2006-08-15 Rib-X Pharmaceuticals, Inc. Bifunctional heterocyclic compounds and methods of making and using same
EP1638549A4 (en) * 2003-03-10 2011-06-15 Optimer Pharmaceuticals Inc NEW ANTIBACTERIAL AGENTS
EP1723159B1 (en) 2004-02-27 2019-06-12 Melinta Therapeutics, Inc. Macrocyclic compounds and methods of making and using the same
EP2214484A4 (en) 2007-10-25 2013-01-02 Cempra Pharmaceuticals Inc PROCESS FOR PREPARING ANTIBACTERIAL MAKROLIDE AGENTS
US8796232B2 (en) 2008-10-24 2014-08-05 Cempra Pharmaceuticals, Inc. Methods for treating resistant diseases using triazole containing macrolides
US9937194B1 (en) 2009-06-12 2018-04-10 Cempra Pharmaceuticals, Inc. Compounds and methods for treating inflammatory diseases
AU2010292010B2 (en) 2009-09-10 2016-01-07 Cempra Pharmaceuticals, Inc. Methods for treating malaria, tuberculosis and MAC diseases
CN102146085B (zh) * 2010-02-09 2014-03-26 北京理工大学 一种9-肟醚酮内酯衍生物、制备方法及其药物组合物
CN103080122A (zh) 2010-03-22 2013-05-01 森普拉制药公司 大环内脂的结晶形式及其用途
US9051346B2 (en) 2010-05-20 2015-06-09 Cempra Pharmaceuticals, Inc. Process for preparing triazole-containing ketolide antibiotics
JP6042334B2 (ja) 2010-09-10 2016-12-14 センプラ ファーマシューティカルズ，インコーポレイテッド 疾患治療のための水素結合形成フルオロケトライド
CN104470527B (zh) 2012-03-27 2019-05-28 森普拉制药公司 用于施用大环内酯抗生素的肠胃外制剂
WO2014152326A1 (en) 2013-03-14 2014-09-25 Cempra Pharmaceuticals, Inc. Methods for treating respiratory diseases and formulations therefor
US9751908B2 (en) 2013-03-15 2017-09-05 Cempra Pharmaceuticals, Inc. Convergent processes for preparing macrolide antibacterial agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL114589A (en) * 1990-11-21 1999-12-22 Roussel Uclaf Intermediates for the preparation of the history of erythromycin
US5527780A (en) * 1992-11-05 1996-06-18 Roussel Uclaf Erythromycin derivatives
FR2718450B1 (fr) * 1994-04-08 1997-01-10 Roussel Uclaf Nouveaux dérivés de l'érythromycine, leur procédé de préparation et leur application comme médicaments.

Also Published As

Publication number Publication date
KR20010013660A (ko) 2001-02-26
HN1998000073A (es) 1999-01-08
BG103947A (en) 2000-07-31
TNSN98083A1 (fr) 2005-03-15
BR9810021A (pt) 2000-09-19
NO996108L (no) 2000-02-10
PE79899A1 (es) 1999-08-25
AP9801253A0 (en) 1999-12-04
HUP0002252A3 (en) 2002-01-28
AR012244A1 (es) 2000-09-27
NO996108D0 (no) 1999-12-10
CA2293335A1 (en) 1998-12-17
CZ9904388A3 (cs) 2002-10-16
GT199800074A (es) 1999-11-27
EA199901016A1 (ru) 2000-06-26
ID24529A (id) 2000-07-20
IS5251A (is) 1999-11-16
EP0988308A1 (en) 2000-03-29
AU7226798A (en) 1998-12-30
HRP980316A2 (en) 1999-04-30
TR199902995T2 (xx) 2000-02-21
PA8451801A1 (es) 2000-05-24
PL337606A1 (en) 2000-08-28
HUP0002252A2 (hu) 2000-12-28
ZA985018B (en) 1999-12-10
IL132767A0 (en) 2001-03-19
OA11225A (en) 2003-07-17
JP2000513026A (ja) 2000-10-03
WO1998056800A1 (en) 1998-12-17
CO4940506A1 (es) 2000-07-24
MA26505A1 (fr) 2004-12-20
CN1259135A (zh) 2000-07-05

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