TW299234B - - Google Patents

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Publication number
TW299234B
TW299234B TW082100772A TW82100772A TW299234B TW 299234 B TW299234 B TW 299234B TW 082100772 A TW082100772 A TW 082100772A TW 82100772 A TW82100772 A TW 82100772A TW 299234 B TW299234 B TW 299234B
Authority
TW
Taiwan
Prior art keywords
weight
composition
formulation
relative humidity
water
Prior art date
Application number
TW082100772A
Other languages
English (en)
Chinese (zh)
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Application granted granted Critical
Publication of TW299234B publication Critical patent/TW299234B/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/008Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy comprising drug dissolved or suspended in liquid propellant for inhalation via a pressurized metered dose inhaler [MDI]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/12Aerosols; Foams
    • A61K9/124Aerosols; Foams characterised by the propellant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW082100772A 1992-02-06 1993-02-05 TW299234B (forum.php)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB929202519A GB9202519D0 (en) 1992-02-06 1992-02-06 Medicaments

Publications (1)

Publication Number Publication Date
TW299234B true TW299234B (forum.php) 1997-03-01

Family

ID=10709929

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082100772A TW299234B (forum.php) 1992-02-06 1993-02-05

Country Status (30)

Country Link
US (2) US5695744A (forum.php)
EP (1) EP0625046B1 (forum.php)
JP (1) JP3675474B2 (forum.php)
CN (1) CN1048394C (forum.php)
AP (1) AP419A (forum.php)
AT (1) ATE157875T1 (forum.php)
AU (1) AU667074B2 (forum.php)
BG (1) BG61862B1 (forum.php)
CA (1) CA2128688A1 (forum.php)
CZ (1) CZ281942B6 (forum.php)
DE (1) DE69313825T2 (forum.php)
DK (1) DK0625046T3 (forum.php)
ES (1) ES2106360T3 (forum.php)
GB (1) GB9202519D0 (forum.php)
GE (1) GEP19991820B (forum.php)
GR (1) GR3025363T3 (forum.php)
HU (2) HUT68986A (forum.php)
IL (1) IL104628A (forum.php)
IS (1) IS1622B (forum.php)
MX (1) MX9300620A (forum.php)
MY (1) MY108748A (forum.php)
NO (1) NO306453B1 (forum.php)
NZ (1) NZ246889A (forum.php)
OA (1) OA10091A (forum.php)
RO (1) RO118173B1 (forum.php)
RU (1) RU2120285C1 (forum.php)
SK (1) SK279291B6 (forum.php)
TW (1) TW299234B (forum.php)
WO (1) WO1993015741A1 (forum.php)
ZA (1) ZA93800B (forum.php)

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US7105152B1 (en) 1991-12-18 2006-09-12 3M Innovative Properties Company Suspension aerosol formulations
US7101534B1 (en) 1991-12-18 2006-09-05 3M Innovative Properties Company Suspension aerosol formulations
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US6932962B1 (en) * 1994-12-22 2005-08-23 Astrazeneca Ab Aerosol drug formulations containing hydrofluoroalkanes and alkyl saccharides
US6013245A (en) * 1995-01-26 2000-01-11 Glaxo Group Limited Aerosol formulation containing beclomethasone dipropionate and 1,1,1,2,3,3,3-heptafluoro-n-propane as propellant
US5874481A (en) * 1995-06-07 1999-02-23 Alliance Pharmaceutical Corp. Fluorochemical solutions for the delivery of lipophilic pharmaceutical agents
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PL193282B1 (pl) * 1997-01-14 2007-01-31 Lohmann Therapie Syst Lts System terapeutyczny do kontrolowanego uwalniania substancji czynnych w przewodzie żołądkowo-jelitowym
US6054487A (en) * 1997-03-18 2000-04-25 Basf Aktiengesellschaft Methods and compositions for modulating responsiveness to corticosteroids
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US6129905A (en) * 1997-04-21 2000-10-10 Aeropharm Technology, Inc. Aerosol formulations containing a sugar as a dispersant
US5891419A (en) * 1997-04-21 1999-04-06 Aeropharm Technology Limited Environmentally safe flunisolide aerosol formulations for oral inhalation
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US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
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CN1138536C (zh) * 1998-03-05 2004-02-18 日本新药株式会社 油/水型脂肪乳或其冻干组合物的应用
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US6458338B1 (en) 1998-09-22 2002-10-01 Aeropharm Technology Incorporated Amino acid stabilized medicinal aerosol formulations
US6136294C1 (en) * 1998-09-22 2002-09-24 Aeropharm Technology Inc Amino acid stabilized medical aerosol formulation
IT1303692B1 (it) * 1998-11-03 2001-02-23 Chiesi Farma Spa Procedimento per la preparazione di sospensioni di particelle difarmaci da somministrare per inalazione.
US7074388B2 (en) * 1998-12-10 2006-07-11 Kos Life Science, Inc. Water stabilized medicinal aerosol formulation
US20060171899A1 (en) * 1998-12-10 2006-08-03 Akwete Adjei Water-stabilized aerosol formulation system and method of making
US6261539B1 (en) * 1998-12-10 2001-07-17 Akwete Adjei Medicinal aerosol formulation
US6540983B1 (en) 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6540982B1 (en) * 2000-01-25 2003-04-01 Aeropharm Technology Incorporated Medical aerosol formulation
US6548049B1 (en) 2000-05-01 2003-04-15 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6447750B1 (en) 2000-05-01 2002-09-10 Aeropharm Technology Incorporated Medicinal aerosol formulation
US6565833B1 (en) 2000-05-01 2003-05-20 Aeropharm Technology Incorporated Medicinal aerosol formulation
US8404217B2 (en) 2000-05-10 2013-03-26 Novartis Ag Formulation for pulmonary administration of antifungal agents, and associated methods of manufacture and use
US7871598B1 (en) 2000-05-10 2011-01-18 Novartis Ag Stable metal ion-lipid powdered pharmaceutical compositions for drug delivery and methods of use
ES2525087T5 (es) 2000-05-10 2018-06-28 Novartis Ag Polvos basados en fosfolípidos para administración de fármacos
AU2001247123A1 (en) * 2000-07-19 2002-02-05 Aeropharm Technology, Inc. A medicinal aerosol formulation
US20020076382A1 (en) * 2000-08-04 2002-06-20 Kaplan Leonard W. Formulations of mometasone and a bronchodilator for pulmonary administration
US6455028B1 (en) 2001-04-23 2002-09-24 Pharmascience Ipratropium formulation for pulmonary inhalation
GB0208742D0 (en) 2002-04-17 2002-05-29 Bradford Particle Design Ltd Particulate materials
MXPA04005865A (es) 2001-12-19 2004-09-13 Nektar Therapeutics Suministro de aminoglucosidos a los pulmones.
EP1415647A1 (en) * 2002-10-23 2004-05-06 CHIESI FARMACEUTICI S.p.A. "Long-acting beta-2 agonists ultrafine formulations"
US7582284B2 (en) 2002-04-17 2009-09-01 Nektar Therapeutics Particulate materials
AU2007231727B2 (en) * 2002-09-03 2010-12-16 Kos Life Sciences, Inc. Water stabilized medicinal aerosol formulation
ME00420B (me) * 2003-03-20 2011-12-20 Boehringer Ingelheim Pharmaceuticals Inc Formulacija, za inhalator u kojem se odmjerava doza, u kojoj se kao propelenti koriste hidro-fluoro-alkani
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AR041873A1 (es) * 2003-10-30 2005-06-01 Pablo Cassara Srl Lab Una formulacion farmaceutica en aerosol adecuada para la inhalacion oral o nasal que contienen glucocorticoides en solucion estable al almacenamiento; un metodo para estabilzar formulaciones y uso de un agente estabilizante
US20050238632A1 (en) * 2004-04-23 2005-10-27 Alburty David S Propellant formulations
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
PL1809243T5 (pl) * 2004-07-02 2022-12-27 Boehringer Ingelheim International Gmbh Preparaty aerozolowe w postaci zawiesin z tg 227 ea jako propelent aerozolowy
GB0417481D0 (en) * 2004-08-05 2004-09-08 Etiologics Ltd Combination therapy
WO2006085102A1 (en) 2005-02-11 2006-08-17 Argenta Discovery Limited Combination of methylxanthine compounds and steroids to treat chronic respiratory diseases
US9084799B2 (en) 2005-02-11 2015-07-21 Pulmagen Therapeutics (Synergy) Limited Inhaled combination therapy
DE102006017320A1 (de) 2006-04-11 2007-10-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Aerosolsuspensionsformulierungen mit TG 227 ea oder TG 134 a als Treibmittel
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DK2425820T3 (en) 2007-02-11 2015-07-13 Map Pharmaceuticals Inc A method for the therapeutic administration of DHE in order to enable quick relief of migraine, while minimizing the adverse event profile
RU2504402C1 (ru) * 2012-11-20 2014-01-20 Шолекс Девелопмент Гмбх Ингаляционный состав в форме аэрозоля для лечения бронхиальной астмы и хронической обструктивной болезни легких

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WO1992006675A1 (en) * 1990-10-18 1992-04-30 Minnesota Mining And Manufacturing Company Aerosol formulation comprising beclomethasone 17,21 dipropionate

Also Published As

Publication number Publication date
CA2128688A1 (en) 1993-08-19
GB9202519D0 (en) 1992-03-25
IS1622B (is) 1996-10-18
US5695744A (en) 1997-12-09
MX9300620A (es) 1993-08-01
GR3025363T3 (en) 1998-02-27
AP419A (en) 1995-10-24
JP3675474B2 (ja) 2005-07-27
HU9402301D0 (en) 1994-10-28
IL104628A0 (en) 1993-06-10
BG61862B1 (bg) 1998-08-31
SK279291B6 (sk) 1998-09-09
AP9300484A0 (en) 1993-04-30
HUT68986A (en) 1995-08-28
CN1078633A (zh) 1993-11-24
JPH07503476A (ja) 1995-04-13
DE69313825T2 (de) 1998-02-05
RU2120285C1 (ru) 1998-10-20
EP0625046B1 (en) 1997-09-10
NZ246889A (en) 1996-11-26
AU667074B2 (en) 1996-03-07
BG98897A (bg) 1995-02-28
US5688782A (en) 1997-11-18
WO1993015741A1 (en) 1993-08-19
AU3452593A (en) 1993-09-03
ES2106360T3 (es) 1997-11-01
NO942923L (no) 1994-08-05
OA10091A (en) 1996-12-18
GEP19991820B (en) 1999-11-05
SK92494A3 (en) 1995-04-12
HU211696A9 (en) 1995-12-28
ATE157875T1 (de) 1997-09-15
RO118173B1 (ro) 2003-03-28
ZA93800B (en) 1993-10-06
IL104628A (en) 1998-12-27
IS3974A (is) 1993-08-07
CZ281942B6 (cs) 1997-04-16
DE69313825D1 (de) 1997-10-16
CN1048394C (zh) 2000-01-19
MY108748A (en) 1996-11-30
NO942923D0 (forum.php) 1994-08-05
DK0625046T3 (da) 1998-04-27
EP0625046A1 (en) 1994-11-23
HK1009588A1 (en) 1999-06-04
NO306453B1 (no) 1999-11-08
CZ184694A3 (en) 1995-03-15

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