|
US6346614B1
(en)
*
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
US6645943B1
(en)
|
1994-10-25 |
2003-11-11 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US6608035B1
(en)
|
1994-10-25 |
2003-08-19 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
CA2246229C
(en)
|
1996-02-14 |
2011-08-23 |
Isis Pharmaceuticals Inc. |
Sugar-modified gapped oligonucleotides
|
|
US20030036516A1
(en)
*
|
1997-09-10 |
2003-02-20 |
Sudhir Agrawal |
Method for using oligonucleotides having modified cpg dinucleotides
|
|
WO1999050409A1
(en)
*
|
1998-04-01 |
1999-10-07 |
Hybridon, Inc. |
Mixed-backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US20040063618A1
(en)
*
|
2002-09-30 |
2004-04-01 |
Muthiah Manoharan |
Peptide nucleic acids having improved uptake and tissue distribution
|
|
US20040186071A1
(en)
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
US20030220486A1
(en)
*
|
1999-04-01 |
2003-11-27 |
Wen-Qiang Zhou |
Mixed backbone oligonucleotides containing pops blocks to obtain reduced phosphorothioate content
|
|
US7276489B2
(en)
*
|
2002-10-24 |
2007-10-02 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5′ ends
|
|
US20050196382A1
(en)
*
|
2002-09-13 |
2005-09-08 |
Replicor, Inc. |
Antiviral oligonucleotides targeting viral families
|
|
JP2005538186A
(ja)
*
|
2002-09-13 |
2005-12-15 |
レプリコール インコーポレーティッド |
非配列相補性の抗ウイルス性オリゴヌクレオチド
|
|
AU2004206820B2
(en)
*
|
2003-01-16 |
2010-06-10 |
Idera Pharmaceuticals, Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by utilizing modified immunostimulatory dinucleotides
|
|
AU2004241093B2
(en)
*
|
2003-05-16 |
2009-08-27 |
Idera Pharmaceuticals, Inc. |
Synergistic treatment of cancer using immunomers in conjunction with chemotherapeutic agents
|
|
CN102604957B
(zh)
|
2003-06-11 |
2015-10-07 |
艾德拉药物股份有限公司 |
稳定的免疫调节寡核苷酸
|
|
EP2363141A1
(en)
|
2003-07-15 |
2011-09-07 |
Idera Pharmaceuticals, Inc. |
Compsition comprising two oligonucleotides linked directly at their 3'ends wherein at leat one oligonucleotide has an accessible 5'end and the compound further comprising IL-2 used for synergistically stimulating an immune response in a patient.
|
|
WO2005060377A2
(en)
|
2003-12-08 |
2005-07-07 |
Hybridon, Inc. |
Modulation of immunostimulatory properties by small oligonucleotide-based compounds
|
|
WO2005081847A2
(en)
*
|
2004-02-20 |
2005-09-09 |
Hybridon, Inc. |
Potent mucosal immune response induced by modified immunomodulatory oligonucleotides
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
EE200700003A
(et)
*
|
2004-06-15 |
2007-06-15 |
Idera Pharmaceuticals, Inc. |
Immunostimuleeriv oligonukleotiid ning selle kasutamine
|
|
US7427405B2
(en)
*
|
2004-06-15 |
2008-09-23 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory oligonucleotide multimers
|
|
US7935811B2
(en)
|
2004-11-22 |
2011-05-03 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing compositions
|
|
US7923207B2
(en)
|
2004-11-22 |
2011-04-12 |
Dharmacon, Inc. |
Apparatus and system having dry gene silencing pools
|
|
US20060166234A1
(en)
|
2004-11-22 |
2006-07-27 |
Barbara Robertson |
Apparatus and system having dry control gene silencing compositions
|
|
WO2006063252A2
(en)
|
2004-12-09 |
2006-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering rnas
|
|
ES2319332T3
(es)
|
2005-05-05 |
2009-05-06 |
Antisense Pharma Gmbh |
Uso terapeutico de oligonucleotidos antisentido tgf-beta 2'.
|
|
ES2450593T3
(es)
*
|
2005-07-01 |
2014-03-25 |
Index Pharmaceuticals Ab |
Método inmunoestimulante
|
|
DK2179737T3
(da)
|
2005-07-01 |
2013-11-11 |
Index Pharmaceuticals Ab |
Modulering af respons på steroider
|
|
WO2007050034A1
(en)
*
|
2005-10-28 |
2007-05-03 |
Index Pharmaceuticals Ab |
Composition and method for the prevention, treatment and/or alleviation of an inflammatory disease
|
|
US7470674B2
(en)
*
|
2005-11-07 |
2008-12-30 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
AU2005338035B2
(en)
|
2005-11-07 |
2012-06-07 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
US7776834B2
(en)
*
|
2005-11-07 |
2010-08-17 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory properties of oligonucleotide-based compounds comprising modified immunostimulatory dinucleotides
|
|
US7786089B2
(en)
*
|
2005-12-20 |
2010-08-31 |
Idera Pharmaceuticals, Inc. |
Immunostimulatory activity of immune modulatory oligonucleotides (IMO™) containing different lengths of palindromic segments
|
|
MX2008008278A
(es)
*
|
2005-12-20 |
2008-10-01 |
Idera Pharmaceuticals Inc |
Agonistas sinteticos novedosos de receptores tipo toll que contienen modificaciones de dinucleotido cg.
|
|
HUE037173T2
(hu)
|
2006-08-08 |
2018-08-28 |
Univ Bonn Rheinische Friedrich Wilhelms |
5'-Foszfát-oligonukleotidok szerkezete és alkalmazása
|
|
US8809514B2
(en)
|
2006-09-22 |
2014-08-19 |
Ge Healthcare Dharmacon, Inc. |
Tripartite oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
EP2338499A1
(en)
|
2006-10-10 |
2011-06-29 |
Gunther Hartmann |
5' triphosphate oligonucleotide induces anti-viral response
|
|
ES2641290T3
(es)
|
2007-11-20 |
2017-11-08 |
Ionis Pharmaceuticals, Inc |
Modulación de la expresión de CD40
|
|
US8188060B2
(en)
|
2008-02-11 |
2012-05-29 |
Dharmacon, Inc. |
Duplex oligonucleotides with enhanced functionality in gene regulation
|
|
US9738680B2
(en)
|
2008-05-21 |
2017-08-22 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
5′ triphosphate oligonucleotide with blunt end and uses thereof
|
|
ES2646097T3
(es)
|
2009-08-27 |
2017-12-12 |
Idera Pharmaceuticals, Inc. |
Composición para inhibir la expresión de genes y sus usos
|
|
US20120270930A1
(en)
|
2009-10-29 |
2012-10-25 |
Academisch Ziekenhuis Leiden H.O.D.N. Lumc |
Methods and compositions for dysferlin exon-skipping
|
|
WO2011109427A2
(en)
|
2010-03-01 |
2011-09-09 |
Alnylam Pharmaceuticals, Inc. |
Improving the biological activity of sirna through modulation of its thermodynamic profile
|
|
EP2453017A1
(en)
|
2010-11-12 |
2012-05-16 |
Antisense Pharma GmbH |
Oligonucleotides for use in prophylaxis and/or treatment of TGF-beta1 and TGF-beta2, TGF-beta2 and TGF-beta3, TGF-beta1 and TGF-beta3, or TGF-beta1, TGF-beta2, and TGF-beta3 mRNA overexpressing diseases
|
|
EP3260540A1
(en)
|
2010-11-12 |
2017-12-27 |
The General Hospital Corporation |
Polycomb-associated non-coding rnas
|
|
US9920317B2
(en)
|
2010-11-12 |
2018-03-20 |
The General Hospital Corporation |
Polycomb-associated non-coding RNAs
|
|
US8877722B2
(en)
|
2011-03-25 |
2014-11-04 |
Idera Pharmaceuticals, Inc. |
Compositions for inhibiting gene expression and uses thereof
|
|
EP2508530A1
(en)
|
2011-03-28 |
2012-10-10 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Purification of triphosphorylated oligonucleotides using capture tags
|
|
EP3533873A1
(en)
|
2011-09-14 |
2019-09-04 |
Translate Bio MA, Inc. |
Multimeric oligonucleotide compounds
|
|
EA201492116A1
(ru)
|
2012-05-16 |
2015-05-29 |
Рана Терапьютикс, Инк. |
Композиции и способы для модулирования экспрессии mecp2
|
|
CA2873794A1
(en)
|
2012-05-16 |
2013-11-21 |
Rana Therapeutics Inc. |
Compositions and methods for modulating smn gene family expression
|
|
CN104583401A
(zh)
|
2012-05-16 |
2015-04-29 |
Rana医疗有限公司 |
用于调节atp2a2表达的组合物和方法
|
|
EP2850188A4
(en)
|
2012-05-16 |
2016-01-20 |
Rana Therapeutics Inc |
COMPOSITIONS AND METHOD FOR MODULATING THE EXPRESSION OF THE HEMOGLOBIN GENE FAMILIES
|
|
US10837014B2
(en)
|
2012-05-16 |
2020-11-17 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating SMN gene family expression
|
|
US10058623B2
(en)
|
2012-05-16 |
2018-08-28 |
Translate Bio Ma, Inc. |
Compositions and methods for modulating UTRN expression
|
|
WO2014030066A2
(en)
|
2012-08-22 |
2014-02-27 |
Bernitz Mats Nilsson |
Methods for identifying nucleic acid sequences
|
|
US20150247141A1
(en)
|
2012-09-14 |
2015-09-03 |
Rana Therapeutics, Inc. |
Multimeric oligonucleotide compounds
|
|
EP2712870A1
(en)
|
2012-09-27 |
2014-04-02 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Novel RIG-I ligands and methods for producing them
|
|
AU2015330731B2
(en)
|
2014-10-10 |
2020-07-09 |
Idera Pharmaceuticals, Inc. |
Treatment of cancer using TLR9 agonist with checkpoint inhibitors
|
|
WO2016070060A1
(en)
|
2014-10-30 |
2016-05-06 |
The General Hospital Corporation |
Methods for modulating atrx-dependent gene repression
|
|
WO2016130943A1
(en)
|
2015-02-13 |
2016-08-18 |
Rana Therapeutics, Inc. |
Hybrid oligonucleotides and uses thereof
|
|
EP3271460A4
(en)
|
2015-03-17 |
2019-03-13 |
The General Hospital Corporation |
RNA INTERACTOM OF POLYCOMB REPRESSIVE COMPLEX 1 (PRC1)
|
|
EP3337516A4
(en)
|
2015-08-21 |
2019-04-03 |
Pfizer Inc |
THERAPEUTIC NANOPARTICLES WITH A THERAPEUTIC PROCESS AND METHOD FOR THE PRODUCTION AND USE THEREOF
|
|
AR125267A1
(es)
|
2021-04-01 |
2023-06-28 |
Biogen Ma Inc |
Administración de ácido nucleico al sistema nervioso central
|
|
WO2025088117A1
(en)
|
2023-10-25 |
2025-05-01 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Ribonucleic acid construct capable of inducing an immune response, as well as pharmaceutical composition and kit comprising same
|
|
WO2025158069A1
(en)
|
2024-01-25 |
2025-07-31 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
CONSTRUCT COMPRISING mRNA-STRAND AND RETINOIC ACID-INDUCIBLE GENE I (RIG-I)-LIGAND(S), PHARMACEUTICAL COMPOSITION AND KIT COMPRISING THE SAME
|