TW233299B - - Google Patents

Info

Publication number
TW233299B
TW233299B TW082104966A TW82104966A TW233299B TW 233299 B TW233299 B TW 233299B TW 082104966 A TW082104966 A TW 082104966A TW 82104966 A TW82104966 A TW 82104966A TW 233299 B TW233299 B TW 233299B
Authority
TW
Taiwan
Prior art keywords
lactol
deoxy
difluoro
contacting
adjusting
Prior art date
Application number
TW082104966A
Other languages
English (en)
Chinese (zh)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25415642&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TW233299(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of TW233299B publication Critical patent/TW233299B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
TW082104966A 1992-06-22 1993-06-22 TW233299B (Sortimente)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,301 US5401861A (en) 1992-06-22 1992-06-22 Low temperature process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (1)

Publication Number Publication Date
TW233299B true TW233299B (Sortimente) 1994-11-01

Family

ID=25415642

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082104966A TW233299B (Sortimente) 1992-06-22 1993-06-22

Country Status (15)

Country Link
US (1) US5401861A (Sortimente)
EP (1) EP0576229B1 (Sortimente)
JP (1) JP3379994B2 (Sortimente)
KR (1) KR100312389B1 (Sortimente)
AT (1) ATE161264T1 (Sortimente)
BR (1) BR9302428A (Sortimente)
CA (1) CA2098886C (Sortimente)
DE (1) DE69315752T2 (Sortimente)
DK (1) DK0576229T3 (Sortimente)
ES (1) ES2112389T3 (Sortimente)
GR (1) GR3026210T3 (Sortimente)
HU (1) HU216840B (Sortimente)
IL (1) IL106076A (Sortimente)
MX (1) MX9303710A (Sortimente)
TW (1) TW233299B (Sortimente)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3485225D1 (de) * 1983-08-18 1991-12-05 Beecham Group Plc Antivirale guanin-derivate.
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
MY164523A (en) * 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
IL153020A0 (en) 2000-05-26 2003-06-24 Idenix Cayman Ltd Methods and compositions for treating flaviviruses and pestiviruses
CN101172993A (zh) * 2002-06-28 2008-05-07 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2′－c－甲基－3′－o－l－缬氨酸酯核糖呋喃基胞苷
US7608600B2 (en) * 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
CN1678326A (zh) * 2002-06-28 2005-10-05 埃迪尼克斯(开曼)有限公司 用于治疗黄病毒感染的2'－c－甲基－3'－o－l－缬氨酸酯核糖呋喃基胞苷
KR20050088079A (ko) 2002-11-15 2005-09-01 이데닉스 (케이만) 리미티드 2'-분지형 뉴클레오시드 및 플라비비리다에 돌연변이
MXPA05006230A (es) * 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
AU2005256963A1 (en) * 2004-06-23 2006-01-05 Centre National De La Recherche Scientifique 5-aza-7-deazapurine derivatives for treating infections with flaviviridae
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
KR100578616B1 (ko) * 2004-07-23 2006-05-10 한미약품 주식회사 Ｄ-에리트로-2,2-다이플루오로-2-데옥시-1-옥소라이보스화합물의 제조방법
EP1781678A4 (en) 2004-07-29 2012-04-25 Hanmi Holdings Co Ltd 1-alpha-halo-2,2-difluoro-2-deoxy-d-ribofuranose derivatives and process for the preparation thereof
KR100699099B1 (ko) * 2004-07-29 2007-03-22 한미약품 주식회사 1-α-할로-2,2-다이플루오로-2-데옥시-Ｄ-라이보퓨라노스유도체 및 이의 제조방법
BRPI0514718A (pt) * 2004-12-30 2008-07-01 Hanmi Pharm Ind Co Ltd método para a preparação de 2'-desoxi-2', 2'-diflúor-citidina
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
ATE458743T1 (de) * 2005-03-04 2010-03-15 Fresenius Kabi Oncology Ltd Zwischenprodukt und verfahren zur herstellung von an beta-anomeren angereicherten 2'-desoxy,2',2'- difluor-d-ribufuranosylnukleosiden
JP4516863B2 (ja) * 2005-03-11 2010-08-04 株式会社ケンウッド 音声合成装置、音声合成方法及びプログラム
JP5091126B2 (ja) * 2005-06-03 2012-12-05 シノファーム タイワン，リミテッド α−アノマーが濃厚な２−デオキシ−２，２−ジフロロ−Ｄ−リボフラノシルスルホネートの製造方法およびβヌクレオシドを製造するためのその使用
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP5254033B2 (ja) * 2005-12-23 2013-08-07 イデニク プハルマセウティカルス，インコーポレイテッド 分岐型ヌクレオシドを調製するための合成中間体の製造方法
KR101357409B1 (ko) 2006-11-03 2014-02-03 에스티팜 주식회사 2′-데옥시-2′,2′-디플루오로시티딘의 제조방법
KR100858842B1 (ko) 2007-03-23 2008-09-22 동우신테크 주식회사 키랄아민을 이용한 광학활성 옥소라이보스유도체의제조방법
EP2139884B1 (en) * 2007-03-23 2013-12-04 Dongwoo Syntech Co., Ltd. Process for preparing of 2'-deoxy-2'2'-difluorocytidine
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
CN109796506A (zh) * 2019-01-28 2019-05-24 江苏八巨药业有限公司 一种吉西他滨关键中间体的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE179713T1 (de) * 1987-08-28 1999-05-15 Lilly Co Eli Verfahren zur selektiven isolierung von beta-2'- desoxy-2'2'-difluorocytidin oder seiner salze
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
CA2098886C (en) 2005-08-09
KR940005655A (ko) 1994-03-22
ES2112389T3 (es) 1998-04-01
HU9301827D0 (en) 1993-09-28
HU216840B (hu) 1999-09-28
CA2098886A1 (en) 1993-12-23
DE69315752D1 (de) 1998-01-29
ATE161264T1 (de) 1998-01-15
MX9303710A (es) 1994-01-31
BR9302428A (pt) 1994-01-11
IL106076A0 (en) 1993-10-20
JPH0656866A (ja) 1994-03-01
IL106076A (en) 2002-02-10
DE69315752T2 (de) 1998-04-23
EP0576229A1 (en) 1993-12-29
US5401861A (en) 1995-03-28
KR100312389B1 (ko) 2002-06-20
HUT64552A (en) 1994-01-28
JP3379994B2 (ja) 2003-02-24
DK0576229T3 (da) 1998-01-19
EP0576229B1 (en) 1997-12-17
GR3026210T3 (en) 1998-05-29

Similar Documents

Publication Publication Date Title
TW233299B (Sortimente)
GR3024975T3 (en) Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonates
EP0352756A3 (en) Selectable aperture module
TW224102B (Sortimente)
AU5333190A (en) Carton forming apparatus with servo control
TW233300B (Sortimente)
KR960008800B1 (en) Movable window, particularly for an automobile
GR3022477T3 (en) Stereoselective process for preparing beta-anomer enriched 2-deoxy-2, 2-difluoro-d-ribofuranosyl-3, 5-hydroxy protected-1-alkyl and aryl sulfonate intermediates.
GR3029572T3 (en) Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates
GR3018063T3 (en) Process for preparation of phosphatidylcholine derivatives.
HUT40133A (en) Process for producing thieno- and furo/2,3-c/ pyrrole derivatives
DE3670844D1 (de) 2,4-dioxopyrrolo(2,3-c)pyrrole.
EP0454494A3 (en) Calicheamicinone, derivatives and analogs thereof and methods of making the same
IL82503A0 (en) Process for the promination of biphenols
AU575134B2 (en) 4,7-dihydropyrazolo (3,4-b) pyridine derivatives
GB8801669D0 (en) Isomerisation process
PT91333A (pt) Processo para a preparacao de um complexo de rodio
YU123987A (en) Controlling circuit for stimmulator, controlled by inclination
HUT42081A (en) Process for preparing 2,3-dichloro-thiophene
SE8902698D0 (sv) Baerregel foer takpannor
IE862786L (en) BENZOPYRANO (2,3-c) PYRROLE COMPOUNDS

Legal Events

Date Code Title Description
MM4A Annulment or lapse of patent due to non-payment of fees