TW223637B - - Google Patents

Info

Publication number
TW223637B
TW223637B TW082100448A TW82100448A TW223637B TW 223637 B TW223637 B TW 223637B TW 082100448 A TW082100448 A TW 082100448A TW 82100448 A TW82100448 A TW 82100448A TW 223637 B TW223637 B TW 223637B
Authority
TW
Taiwan
Prior art keywords
antirheumatic
chem
iii
image
active ingredient
Prior art date
Application number
TW082100448A
Other languages
English (en)
Chinese (zh)
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of TW223637B publication Critical patent/TW223637B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/06—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4
    • C07D475/08—Heterocyclic compounds containing pteridine ring systems with a nitrogen atom directly attached in position 4 with a nitrogen atom directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
TW082100448A 1992-01-27 1993-01-27 TW223637B (US07229986-20070612-C00198.png)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP5305192 1992-01-27
JP7510692 1992-02-13
JP10832092 1992-03-16
JP11512692 1992-03-24

Publications (1)

Publication Number Publication Date
TW223637B true TW223637B (US07229986-20070612-C00198.png) 1994-05-11

Family

ID=27462860

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082100448A TW223637B (US07229986-20070612-C00198.png) 1992-01-27 1993-01-27

Country Status (10)

Country Link
US (2) US6559149B1 (US07229986-20070612-C00198.png)
EP (1) EP0632038B1 (US07229986-20070612-C00198.png)
KR (1) KR100248324B1 (US07229986-20070612-C00198.png)
AT (1) ATE204576T1 (US07229986-20070612-C00198.png)
AU (1) AU3367693A (US07229986-20070612-C00198.png)
CA (1) CA2128205C (US07229986-20070612-C00198.png)
DE (1) DE69330639T2 (US07229986-20070612-C00198.png)
ES (1) ES2161713T3 (US07229986-20070612-C00198.png)
TW (1) TW223637B (US07229986-20070612-C00198.png)
WO (1) WO1993015077A1 (US07229986-20070612-C00198.png)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU3367693A (en) * 1992-01-27 1993-09-01 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
AU5715894A (en) * 1992-12-25 1994-07-19 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
KR100400509B1 (ko) * 1995-03-27 2004-04-03 쥬가이 세이야쿠 가부시키가이샤 메토트렉세이트유도체를함유하는약제
US7276506B2 (en) * 1998-12-28 2007-10-02 4 Aza Bioscience Nv Immunosuppressive effects of pteridine derivatives
AU2001256733A1 (en) * 2000-05-16 2001-11-26 Takeda Chemical Industries Ltd. Melanin-concentrating hormone antagonist
US20070032477A1 (en) * 2003-10-17 2007-02-08 Waer Mark J A Pteridine derivatives useful for making pharmaceutical compositions
US20060039985A1 (en) * 2004-04-27 2006-02-23 Bennett David B Methotrexate compositions
US7601834B2 (en) * 2005-02-22 2009-10-13 Savvipharm Inc Compositions and methods of reducing side effects and toxicity of methotrexate when given as orotate derivatives
PT1954292E (pt) 2005-11-28 2014-08-04 Verrow Pharmaceuticals Inc Composições úteis para reduzir a nefrotoxicidade e métodos para a sua utilização
WO2007098089A2 (en) * 2006-02-17 2007-08-30 Novacea, Inc. Treatment of hyperproliferative diseases with methotrexate n-oxide and analogs
WO2008009079A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. Substituted pteridines useful for the treatment and prevention of viral infections
AU2008237934B2 (en) 2007-04-11 2014-03-27 Merck & Cie 18F-labelled folates
CA2742909C (en) 2008-11-19 2017-12-19 Pola Chemical Industries Inc. Anti-wrinkle agents
PL3097102T3 (pl) 2015-03-04 2018-04-30 Gilead Sciences Inc Związki 4,6-diamino-pirydo[3,2-d]pirymidyny modulujące działanie receptora toll-podobnego
EP3507288B1 (en) 2016-09-02 2020-08-26 Gilead Sciences, Inc. 4,6-diamino-pyrido[3,2-d]pyrimidine derivaties as toll like receptor modulators
EP3507276B1 (en) 2016-09-02 2021-11-03 Gilead Sciences, Inc. Toll like receptor modulator compounds
TW202212339A (zh) 2019-04-17 2022-04-01 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202210480A (zh) 2019-04-17 2022-03-16 美商基利科學股份有限公司 類鐸受體調節劑之固體形式
TW202115056A (zh) 2019-06-28 2021-04-16 美商基利科學股份有限公司 類鐸受體調節劑化合物的製備方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI812775L (fi) * 1980-09-12 1982-03-13 Farmos Oy Foerfarande foer framstaellning av n-/4-/(2,4-diamino-6-pteridinyl)-metyl/metylamino/benzoyl/glutaminsyra och derivat daerav
US4490529A (en) * 1983-09-06 1984-12-25 Dana-Farber Cancer Institute, Inc. Cysteic acid and homocysteic acid analogues of methotrexate and aminopterin
ATE187455T1 (de) * 1990-08-14 1999-12-15 Chugai Pharmaceutical Co Ltd Methotrexatderivate mit antirheumatischer aktivität
JP3124592B2 (ja) * 1990-08-14 2001-01-15 中外製薬株式会社 新規メトトレキセート誘導体
AU3367693A (en) * 1992-01-27 1993-09-01 Chugai Seiyaku Kabushiki Kaisha Methotrexate derivative
JP3207285B2 (ja) * 1992-01-27 2001-09-10 中外製薬株式会社 新規メトトレキセート誘導体
JP3274532B2 (ja) * 1992-03-24 2002-04-15 中外製薬株式会社 抗リウマチ剤

Also Published As

Publication number Publication date
CA2128205C (en) 2004-03-30
CA2128205A1 (en) 1993-08-05
US20030171376A1 (en) 2003-09-11
WO1993015077A1 (en) 1993-08-05
EP0632038B1 (en) 2001-08-22
US6559149B1 (en) 2003-05-06
EP0632038A4 (en) 1995-02-22
EP0632038A1 (en) 1995-01-04
DE69330639T2 (de) 2002-07-04
ES2161713T3 (es) 2001-12-16
ATE204576T1 (de) 2001-09-15
KR100248324B1 (ko) 2000-04-01
AU3367693A (en) 1993-09-01
DE69330639D1 (de) 2001-09-27

Similar Documents

Publication Publication Date Title
TW223637B (US07229986-20070612-C00198.png)
IL96882A0 (en) Uracil derivatives and pesticides containing the same as active ingredient
AU628138B2 (en) Triazine derivative and herbicide containing the same as active ingredient
EP0705833A4 (en) DC-89 DERIVATIVES
CA2064634A1 (en) 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
IL99106A0 (en) Novel tricyclic compound or salts thereof,method for producing the same and antimicrobial agent containing the same
AU7415387A (en) Imidazolesulfonamide derivatives and herbicides
AU657397B2 (en) 3,4-diaryl-(5H)-furan-2-one based compounds with fungicidal activity
AU6117698A (en) Antiviral agents
AU5715894A (en) Methotrexate derivative
HU9503388D0 (en) Anxiolytic agent
EP0659752A4 (US07229986-20070612-C00198.png)
GR3025084T3 (en) Acrylic derivatives of 2-thiazolypyrroles having a fungicidal activity