TW202417465A - 環肽或其鹽及ｍｄｍｘ抑制劑 - Google Patents

環肽或其鹽及ｍｄｍｘ抑制劑 Download PDF

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Publication number
TW202417465A
TW202417465A TW112131447A TW112131447A TW202417465A TW 202417465 A TW202417465 A TW 202417465A TW 112131447 A TW112131447 A TW 112131447A TW 112131447 A TW112131447 A TW 112131447A TW 202417465 A TW202417465 A TW 202417465A
Authority
TW
Taiwan
Prior art keywords
cyclic peptide
group
acid
bonded
salt
Prior art date
Application number
TW112131447A
Other languages
English (en)
Chinese (zh)
Inventor
金子麻依
田村崇
鈴木晃生
津村享佑
大橋紀之
公地將大
橋本一彥
宮原建太
堀込弘記
Original Assignee
日商富士軟片股份有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 日商富士軟片股份有限公司 filed Critical 日商富士軟片股份有限公司
Publication of TW202417465A publication Critical patent/TW202417465A/zh

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K4/00—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW112131447A 2022-08-23 2023-08-22 環肽或其鹽及ｍｄｍｘ抑制劑 TW202417465A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2022132147 2022-08-23
JP2022-132147 2022-08-23

Publications (1)

Publication Number Publication Date
TW202417465A true TW202417465A (zh) 2024-05-01

Family

ID=90013421

Family Applications (1)

Application Number Title Priority Date Filing Date
TW112131447A TW202417465A (zh) 2022-08-23 2023-08-22 環肽或其鹽及ｍｄｍｘ抑制劑

Country Status (5)

Country Link
US (1) US20250179120A1 (https=)
EP (1) EP4578868A4 (https=)
JP (1) JPWO2024043250A1 (https=)
TW (1) TW202417465A (https=)
WO (1) WO2024043250A1 (https=)

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5605602B2 (ja) 2007-03-26 2014-10-15 国立大学法人 東京大学 環状ペプチド化合物の合成方法
EP2647721B1 (en) * 2010-12-03 2019-02-27 The University of Tokyo Peptide with safer secondary structure, peptide library, and production methods for same
TW202446781A (zh) * 2011-12-28 2024-12-01 日商中外製藥股份有限公司 胜肽化合物之製造方法
EP2819688A4 (en) * 2012-02-15 2015-10-28 Aileron Therapeutics Inc TRIAZOL AND THIOETHER-COUPLED PEPTIDOMIMETIC MACROCYCLES
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
JP6754997B2 (ja) 2013-08-26 2020-09-16 国立大学法人 東京大学 大環状ペプチド、その製造方法、及び大環状ペプチドライブラリを用いるスクリーニング方法
EP3126375B1 (en) 2014-04-02 2023-12-13 University of Rochester Macrocyclic peptidomimetics for alpha-helix mimicry
IL293239A (en) 2019-11-21 2022-07-01 Unnatural Products Inc Cell-permeable cyclic peptides and their uses
US11939403B2 (en) * 2020-07-02 2024-03-26 The Regents Of The University Of California Peptide-peptoid scaffolds
JP7057003B1 (ja) * 2021-02-26 2022-04-19 国立大学法人東京工業大学 予測装置、学習済みモデルの生成装置、予測方法、学習済みモデルの生成方法、予測プログラム、及び学習済みモデルの生成プログラム
TW202313092A (zh) * 2021-05-26 2023-04-01 美商非自然產物公司 細胞可穿透環狀肽及其用途
TW202417032A (zh) * 2022-08-23 2024-05-01 日商富士軟片股份有限公司 環肽或其鹽及ｍｄｍｘ抑制劑
JPWO2024043251A1 (https=) * 2022-08-23 2024-02-29

Also Published As

Publication number Publication date
US20250179120A1 (en) 2025-06-05
EP4578868A4 (en) 2025-12-17
WO2024043250A1 (ja) 2024-02-29
EP4578868A1 (en) 2025-07-02
JPWO2024043250A1 (https=) 2024-02-29

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