TW202334125A - Cdk4抑制劑之固體形式 - Google Patents

Cdk4抑制劑之固體形式 Download PDF

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Publication number
TW202334125A
TW202334125A TW112102545A TW112102545A TW202334125A TW 202334125 A TW202334125 A TW 202334125A TW 112102545 A TW112102545 A TW 112102545A TW 112102545 A TW112102545 A TW 112102545A TW 202334125 A TW202334125 A TW 202334125A
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TW
Taiwan
Prior art keywords
ppm
cancer
solid
crystalline form
values
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TW112102545A
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English (en)
Chinese (zh)
Inventor
衛斯理 德韋特 克拉克
茱蒂絲 蓋兒 迪奧
布萊恩 馬修 薩瑪斯
Original Assignee
美商輝瑞大藥廠
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Application filed by 美商輝瑞大藥廠 filed Critical 美商輝瑞大藥廠
Publication of TW202334125A publication Critical patent/TW202334125A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Fats And Perfumes (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW112102545A 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式 TW202334125A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US202063078636P 2020-09-15 2020-09-15
US63/078,636 2020-09-15
US202163240268P 2021-09-02 2021-09-02
US63/240,268 2021-09-02

Publications (1)

Publication Number Publication Date
TW202334125A true TW202334125A (zh) 2023-09-01

Family

ID=78000744

Family Applications (2)

Application Number Title Priority Date Filing Date
TW112102545A TW202334125A (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式
TW110134168A TWI809503B (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式

Family Applications After (1)

Application Number Title Priority Date Filing Date
TW110134168A TWI809503B (zh) 2020-09-15 2021-09-14 Cdk4抑制劑之固體形式

Country Status (18)

Country Link
US (1) US20230357211A1 (cg-RX-API-DMAC7.html)
EP (2) EP4578450A3 (cg-RX-API-DMAC7.html)
JP (2) JP7260606B2 (cg-RX-API-DMAC7.html)
KR (1) KR20230069983A (cg-RX-API-DMAC7.html)
CN (1) CN116507620B (cg-RX-API-DMAC7.html)
AU (1) AU2021345531B2 (cg-RX-API-DMAC7.html)
CA (1) CA3195063A1 (cg-RX-API-DMAC7.html)
DK (1) DK4214202T3 (cg-RX-API-DMAC7.html)
ES (1) ES3022913T3 (cg-RX-API-DMAC7.html)
FI (1) FI4214202T3 (cg-RX-API-DMAC7.html)
HU (1) HUE070846T2 (cg-RX-API-DMAC7.html)
MX (1) MX2023003054A (cg-RX-API-DMAC7.html)
PL (1) PL4214202T3 (cg-RX-API-DMAC7.html)
PT (1) PT4214202T (cg-RX-API-DMAC7.html)
SI (1) SI4214202T1 (cg-RX-API-DMAC7.html)
TW (2) TW202334125A (cg-RX-API-DMAC7.html)
WO (1) WO2022058871A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA202303655B (cg-RX-API-DMAC7.html)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2022002415A (es) 2019-08-26 2022-03-22 Arvinas Operations Inc Metodos de tratamiento del cancer de mama con derivados de tetrahidronaftaleno como degradadores del receptor de estrogenos.
KR20240112931A (ko) * 2021-12-02 2024-07-19 화이자 인코포레이티드 암 치료를 위한 cdk4 억제제
KR20250040736A (ko) 2022-07-29 2025-03-24 화이자 인코포레이티드 암의 치료를 위한 kat6 억제제를 포함하는 투여 요법
CN120981721A (zh) 2023-03-30 2025-11-18 辉瑞大药厂 Kat6a作为用kat6a抑制剂治疗的预测性生物标志物和相关治疗方法
WO2024201340A1 (en) 2023-03-30 2024-10-03 Pfizer Inc. Kat6a as a predictive biomarker for treatment of breast cancer with a cdk4 inhibitor and an antiestrogen and methods of treatment thereof
WO2024246825A1 (en) 2023-06-02 2024-12-05 Pfizer Inc. Combinations of estrogen receptor degraders and cdk4 inhibitors
WO2024246824A1 (en) 2023-06-02 2024-12-05 Pfizer Inc. Methods and modified dosing regimens comprising a cdk4 inhibitor for the treatment of cancer
TW202513069A (zh) 2023-07-21 2025-04-01 美商冰洲石生物科技公司 作為週期蛋白依賴性激酶抑制劑之胺基嘧啶衍生物
WO2025104624A1 (en) 2023-11-14 2025-05-22 Pfizer Inc. Synthesis of 1,5-anhydro-3-({5-chloro-4-[4-fluoro-2-(2-hydroxypropan-2-yl)-1-(propan-2-yl)-1h-benzimidazol-6-yl]pyrimidin-2-yl}amino)-2,3-dideoxy-d-threo-pentitol
WO2025202854A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors and combinations with cdk2 inhibitors or further agents for use in the treatment of cancer
WO2025202900A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Cdk4 inhibitors for use in the treatment of mantle cell lymphoma
WO2025202871A1 (en) 2024-03-27 2025-10-02 Pfizer Inc. Methods for identifying biomarkers of treatment response and use thereof with a cdk4 inhibitor

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
EP3484871B1 (en) * 2016-07-13 2023-06-07 Syros Pharmaceuticals, Inc. Piperidine derivatives as inhibitors of cyclin dependent kinase 7 (cdk7)
CR20190062A (es) 2016-08-15 2019-05-22 Pfizer Inhibidores de cdk2/4/6
RS66650B1 (sr) 2018-04-26 2025-04-30 Pfizer 2-amino-piridin ili 2-amino-pirimidin derivati kao inhibitori kinaza zavisnih od clklina

Also Published As

Publication number Publication date
SI4214202T1 (sl) 2025-05-30
JP2022186995A (ja) 2022-12-15
JP7260606B2 (ja) 2023-04-18
DK4214202T3 (da) 2025-03-31
EP4214202B1 (en) 2025-02-26
MX2023003054A (es) 2023-04-05
CN116507620A (zh) 2023-07-28
PT4214202T (pt) 2025-04-11
JP2022049005A (ja) 2022-03-28
CN116507620B (zh) 2025-11-18
ZA202303655B (en) 2024-09-25
TW202216698A (zh) 2022-05-01
US20230357211A1 (en) 2023-11-09
EP4578450A3 (en) 2025-07-16
PL4214202T3 (pl) 2025-05-19
AU2021345531B2 (en) 2024-02-29
WO2022058871A1 (en) 2022-03-24
TWI809503B (zh) 2023-07-21
EP4578450A2 (en) 2025-07-02
BR112023004713A2 (pt) 2023-04-18
ES3022913T3 (en) 2025-05-29
KR20230069983A (ko) 2023-05-19
AU2021345531A1 (en) 2023-04-20
FI4214202T3 (fi) 2025-04-25
HUE070846T2 (hu) 2025-07-28
CA3195063A1 (en) 2022-03-24
JP7291839B2 (ja) 2023-06-15
EP4214202A1 (en) 2023-07-26

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