TW202330006A - 氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物 - Google Patents
氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物 Download PDFInfo
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Abstract
本發明之組合物包含下述之成分(1)、成分(2)、成分(3)及成分(4)作為有效成分:
成分(1):選自由炙甘草、甘草、山藥、大棗、膠飴及人參所組成之群中之至少1種生藥;
成分(2):選自由薑黃、龍眼肉、莪朮、雞血藤、絲瓜絡、三棱、紅花及劉寄奴所組成之群中之至少1種生藥;
成分(3):選自由茶葉、薄荷、桑葉、菊花及香鼓所組成之群中之至少1種生藥;
成分(4):選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、蔥白、酸棗仁、柏子仁、車前子、車前草、薏苡仁、玉米鬚、地膚子、冬瓜子、扁蓄、金錢草、肉桂、乾薑、小茴香、蜀椒、胡椒、刺五加及艾葉所組成之群中之至少2種生藥。
Description
本發明係關於一種氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物。
於作為代表性之傳統醫學體系之中國醫學及起源於其之漢方醫學中,作為解釋身體狀況、體質及所攝取之食品、醫藥品所造成之影響之基本概念,「氣血水」論已成體系。其為如下理念,即,例舉氣、血、水之三要素作為構成身體之要素,作為其等不足、流動不暢等失衡之結果來分類身體狀況、體質。
其中,「氣」係指生物體之能量,認為其係有其能而無其形者,循行於經絡中游走全身而滋養並保護所有臟腑以維持生命。於西洋醫學上,可解釋為「氣」主要與神經系統、內分泌系統等生物體之訊息傳遞系統之功能相關。「氣」之異常包括因氣之產生障礙或消耗過多而導致氣不足之「氣虛」、表示氣自下半身上升至上半身之狀態之「氣上沖(氣逆)」、氣郁滯於各種部位之「氣鬱」,與各種健康異常相關聯地進行理解(非專利文獻1、2)。
又,「血」於現象上係指血液,其係亦包含其功能之概念。認為「血」藉由「氣」之作用而遊走全身,為各組織帶來所需之營養,係塑造身形之源泉。「血」之異常包括血量發生不足之病情即「血虛」、阻礙血之流通導致淤滯之病情即「淤血」,與各種健康異常相關聯地進行理解(非專利文獻1、2)。
認為氣虛、即「氣」不足係基於胃腸功能及消化吸收功能下降者,其係指虛弱無力,無法活躍地活動之狀態。作為與此相伴之不適症狀,可例舉:倦怠感、精力下降、易疲勞感、慢性疲勞、白天嗜睡、食慾不振、易感染性(容易感冒)、發育不良、怕冷、四肢冰冷、乏力感、腹瀉、水腫、消化不良、消瘦、皮膚乾燥、多汗、以情緒抑鬱為代表之精神不穩定、易出血、腎氣不足即排尿功能異常引起之尿量異常、頻尿、遺尿、尿失禁、夜尿等(非專利文獻1~4)。
又,推定血虛、即「血」量不足係因血液、免疫系統之異常而陷入不足者,作為與此相伴之不適症狀,可例舉:貧血、免疫功能下降、注意力下降、失眠、睡眠障礙、易脫髮、眼睛疲勞、皮膚乾燥及粗燥、指甲異常、肌肉抽搐、知覺異常、月經過少、月經不調、面色不佳等(非專利文獻1、2)。
於漢方醫學中,以辯證論治為原則,即,辨明疾病之原因,並投予與其相對應之處方。針對氣虛及/或血虛相關症狀,提出有各種漢方藥(混合生藥)。例如,針對氣虛相關症狀,可例舉四君子湯,針對血虛相關症狀,可例舉四物湯等(非專利文獻1、2)。該等漢方藥含有多種生藥成分,應按照醫師之處方服用。
[先前技術文獻]
[非專利文獻]
[非專利文獻1]柴原直利,漢方醫藥中之基本用語,Pharmacia,第47卷第5號(2011),p408-412
[非專利文獻2]松田邦夫、稻木一元(編輯),臨床醫生用之漢方(基礎篇)(1987),Current Therapy股份有限公司,p12-14
[非專利文獻3]仙頭正四郎,系統中醫學講座 摘要 第4期,氣血津液之生理功能與失調,中醫臨床,第23卷第3號(2002),p46-54
[非專利文獻4]山田光胤、橋本竹二郎(作者),福島普德(編輯),圖說 東洋醫學<湯液篇I 漢方開設>(1984),東京印書館股份有限公司,p27-28
[發明所欲解決之問題]
本發明之目的在於提供一種氣虛及/或血虛相關症狀之預防、改善或緩和用之包含生藥成分之組合物。
[解決問題之技術手段]
本發明人等為實現上述目的而反覆進行了銳意研究,結果發現,藉由選定並調配特定之歸經及性味之生藥群,可預防、改善或緩和氣虛及/或血虛相關症狀。本發明係基於本見解進一步反覆研究而完成者,提供一種含有生藥成分之新穎組合物。
即,本發明例如如下所述。
[1]
一種組合物,其包含下述之成分(1)、成分(2)、成分(3)及成分(4)作為效成分:
成分(1):選自由炙甘草、甘草、山藥、大棗、膠飴及人參所組成之群中之至少1種生藥;
成分(2):選自由薑黃、龍眼肉、莪朮、雞血藤、絲瓜絡、三棱、紅花及劉寄奴所組成之群中之至少1種生藥;
成分(3):選自由茶葉、薄荷、桑葉、菊花及香鼓所組成之群中之至少1種生藥;
成分(4):選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、蔥白、酸棗仁、柏子仁、車前子、車前草、薏苡仁、玉米鬚、地膚子、冬瓜子、扁蓄、金錢草、肉桂、乾薑、小茴香、蜀椒、胡椒、刺五加及艾葉所組成之群中之至少2種生藥。
[2]
如[1]所記載之組合物,其用於預防、改善或緩和氣虛及/或血虛相關症狀。
[3]
如[2]所記載之組合物,其中氣虛及/或血虛相關症狀為選自由慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、失眠、及睡眠障礙所組成之群中之至少1種。
[4]
如[1]至[3]中任一項所記載之組合物,其係食品組合物或醫藥組合物。
[5]
一種預防、改善或緩和氣虛及/或血虛相關症狀之方法,其包括將如[1]至[4]中任一項所記載之組合物施予給需要其之對象之步驟。
[6]
如[1]至[4]中任一項所記載之組合物,其用於預防、改善或緩和氣虛及/或血虛相關症狀。
[7]
一種如[1]至[4]中任一項所記載之組合物之用途,其係用於製造氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物。
[8]
一種如[1]至[4]中任一項所記載之組合物之用途,其係用於氣虛及/或血虛相關症狀之預防、改善或緩和。
[發明之效果]
本發明之組合物可藉由調配特定之歸經及性味之生藥,而產生氣並作用於與抵抗力、虛弱相關之中焦,養氣補氣虛,又,藉由所補之氣之作用補血虛,並且協同地表現出精神穩定作用,預防、改善或緩和氣虛及/或血虛相關各種症狀。尤其對慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、失眠、睡眠障礙等症狀有效。
「氣」表示生物體之能量,認為其主要與神經系統、內分泌系統等生物體之訊息傳遞系統之功能相關。「氣虛」係指生物體之能量不足之狀態。認為其為虛弱無力,無法活躍地活動之狀態,係基於胃腸功能及消化吸收功能下降者。作為氣虛相關症狀,可例舉:慢性疲勞、易疲勞感、倦怠感、乏力感、精力下降、精神不穩定、腹瀉、尿量異常、頻尿、遺尿、尿失禁、夜尿、白天嗜睡、食慾不振、易感染性、發育不良、怕冷、四肢冰冷、水腫、消化不良、消瘦、皮膚乾燥、多汗、易出血等。
認為「血虛」係指血液、免疫系統之功能衰退之狀態。作為血虛相關症狀,可例舉:貧血、免疫力下降、注意力下降、失眠、睡眠障礙、易脫髮、眼睛疲勞、皮膚乾燥及粗燥、指甲異常、肌肉抽搐、知覺異常、月經過少、月經不調、四肢冰冷、易疲勞、易感染性、面色不佳等。
於本說明書中,氣虛及/或血虛相關症狀(病變或身體不適)主要為氣虛相關症狀,進而指由氣虛引起之血虛相關各種症狀。更具體而言,可例舉選自由慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、失眠、睡眠障礙所組成之群中之至少1種,可較佳地例舉慢性疲勞、易疲勞感、倦怠感、精力下降、失眠、睡眠障礙等,可尤佳地例舉慢性疲勞、易疲勞感、倦怠感、精力下降等。此處,「尿量異常」係指尿量較少或較多,尤其係指尿量較少。氣虛及/或血虛相關症狀進而可包含乏力感、腹瀉、頻尿、食慾不振、尿失禁、四肢冰冷、怕冷、易感染性、多汗、面色不佳等。
氣虛及/或血虛相關諸症狀亦存在因除氣虛及/或血虛以外之原因引起之情況。例如,存在因細菌性、毒物、藥物等引起腹瀉等症狀之情況,又,存在因短暫性肌肉痛、過度疲勞、營養不足或暴食等引起倦怠感等症狀之情況。然而,於此種情形時,若該等特定之原因消失,則症狀通常會恢復。另一方面,由於氣虛及/或血虛係與「氣」及/或「血」之不足相關者,故而多為慢性症狀,又,多數情況下無法想到特定之明顯原因。因此,若上述例舉之氣虛及/或血虛相關諸症狀中之至少1種(例如至少2種、至少3種、至少4種、至少5種、至少6種、或至少7種)持續1週以上、2週以上、4週以上、3個月以上、6個月以上或1年以上時間,則為氣虛及/或血虛相關症狀之可能性較高,進而,於沒有想到該等症狀之直接原因之情形時,為氣虛及/或血虛之可能性更高。更確實而言,基於中國醫學,可診斷是否為氣虛及/或血虛。
本實施方式之組合物包含成分(1)、成分(2)、成分(3)、及成分(4)作為有效成分。成分(1)、成分(2)、成分(3)及成分(4)分別包含一組具有特定之歸經及性味之生藥。各生藥之歸經、性味及功效如下所述。又,各生藥可使用通常已知之來源及部位,詳細內容如下所述。
此處,歸經為中國醫學(中醫學)中使用之概念之一,係指生藥作用於人體之哪一部分,表示發揮藥效之作用部位。歸經包含所謂之「五臟」,即「肝、心、脾、肺、腎」,但中國醫學上之五臟與解剖學上之器官不一致,更意指人體之「功能」。肝與自主神經、情緒、運動神經、婦科系統、及肝臟相關,存儲血液並進行控制以使氣血順暢流動。心與包括腦、心臟之循環系統相關,具有使血液全身循環並進行滋養之作用。脾與消化系統、過敏、及水分代謝之一部分相關,消化吸收飲食物,生成作為身體之根本之「氣血水」。肺與呼吸系統、皮膚、水分代謝之一部分、及過敏相關,與脾協作生成「氣」,散佈全身,調節水之循環,保護身體免受外邪侵害,與免疫力關係密切。腎與生殖系統、泌尿系統、內分泌系統、老化或發育相關,存儲生命能量之源,控制全身之水之代謝,生成尿並再吸收。於中國醫藥中,認為五臟共同地生成或存儲人體之精氣,亦控制精神活動。
性味(亦稱為「氣味」)係表示生藥之性質之一種分類體系,每種味道均與五臟相關,又,味道本身均有其各自之作用。最通常而言,藉由「寒、涼、平、溫、熱」之五性來表示使人體變冷或變暖之性質,又,藉由「辛、甘、酸、苦、鹹」之五味來表示攝取時之味道,並且亦為功效之指標。亦存在於五味中進而加入「淡、澀」之情況。「熱」及「溫」具有驅寒暖身,促進興奮、活躍之作用,另一方面,「寒」及「涼」具有清熱、解毒、鎮靜安神之作用,「平」係指既不溫亦不冷之性質。「寒」亦存在視程度進而分為「大寒」、「寒」、「微寒」之情況。「辛」與肺相關,具有發汗、行氣、宣散之作用。「甘」與脾相關,具有補益或緩和之作用。「酸」與肝相關,具有收斂之作用。「苦」與心相關,具有清熱、燥濕、瀉下之作用。「鹹」與腎相關,具有軟堅潤下之作用。性味亦存在視程度細分為「大寒」、「微苦」等之情況。
大致所有之生藥均設定有歸經及性味,對於歸經及/或性味一致之生藥,其功效亦相同之傾向較強,其為有助於龐大之生藥之功效、處方設計之體系化之技術思想之代表性者。
又,作為生藥之分類,可例舉:辛涼解表藥、清熱瀉火藥、催吐藥、導瀉藥、利水滲濕藥、祛風濕藥、祛寒藥、清熱藥、鎮咳去痰藥、理氣藥、補氣藥、理血藥、養血藥、活血化瘀藥、補養藥、芳香開竅藥、鎮靜鎮痙藥、收澀藥、消化藥、驅蟲藥、及外用藥等。
<成分(1)>
成分(1)係歸經為「脾」之生藥,具體而言,為選自由炙甘草、甘草、山藥、大棗、膠飴及人參所組成之群中之至少1種。該等生藥中,就容易獲取(供給穩定性)之觀點而言,較佳為選自由炙甘草、甘草、山藥、大棗及膠飴所組成之群中之至少1種,就以較少之原料生藥量發揮效果之觀點而言,較佳為選自由炙甘草、甘草及大棗所組成之群中之至少1種。作為成分(1),可為至少1種生藥、至少2種生藥、至少3種生藥、或至少4種生藥。
炙甘草為將烏拉爾甘草(Glycyrrhiza uralensis Fisch.)或西班牙甘草(Glycyrrhiza glabra L.)之乾燥根及莖直接或塗抹蜂蜜烘製而得者,性味為平、甘,歸經為十二經,功效為補中益氣、潤肺、祛痰止咳、緩急止痛、清熱解毒、調和藥性。主成分為三萜糖苷、黃烷酮糖苷。
甘草為將烏拉爾甘草(Glycyrrhiza uralensis Fisch.)或西班牙甘草(Glycyrrhiza glabra L.)之根及莖之乾燥而得者,性味為平、甘,歸經為十二經,功效為補中益氣、潤肺、祛痰止咳、緩急止痛、清熱解毒、調和藥性。主成分為三萜糖苷、黃烷酮糖苷。
山藥為將去除山芋(Dioscorea japonica Thunb.)或長芋(Dioscorea batatas Decne.)之周皮後之根莖(根托)乾燥而得者,性味為平、甘,歸經為脾、肺、腎,功效為補脾止瀉、養陰扶脾、養肺益陰、止咳、補腎固精、縮尿、止帶。主成分為多糖類(澱粉、糖蛋白質)。
大棗為將紅棗(Zizyphus jujuba Mill. var. inermis (Bunge) Rehder)之果實乾燥而得者,性味為微溫、甘,歸經為脾、胃、心、肝,功效為補脾和胃、養營安神、緩和藥性。主成分為果糖、葡萄糖。
膠飴為將玉米(Zea mays L.)、木薯(Manihot esculenta Crantz)、馬鈴薯(Solanum tuberosum L.)、甘薯(Ipomoea batatas (L.) Poir.)、或水稻(Oryza sativa L.)之澱粉或去除水稻之種皮後之種子水解並進行糖化而得者,性味為微溫、甘,歸經為脾、胃、肺,功效為補虛建中、緩急止痛、潤肺止咳。主成分為麥芽糖。
人參為將朝鮮人參(Panax ginseng C.A. Mey.)之去除鬚根後之根或將其輕輕漂燙並乾燥而得者,性味為微溫、甘、微苦,歸經為肺、脾,功效為補氣固脫、補脾氣、益肺氣、生津止渴。主成分為皂苷、類黃酮。
<成分(2)>
成分(2)係歸經為「肝」或「脾」之生藥,具體而言,為選自由薑黃、龍眼肉、莪朮、雞血藤、絲瓜絡、三棱、紅花及劉寄奴所組成之群中之至少1種。該等生藥中,就容易獲取(供給穩定性)之觀點而言,較佳為選自由薑黃、龍眼肉、莪朮、雞血藤、絲瓜絡及紅花所組成之群中之至少1種,就功效之觀點而言,更佳為選自由薑黃、莪朮、雞血藤及紅花所組成之群中之至少1種,尤佳為選自由薑黃、莪朮及雞血藤所組成之群中之至少1種。作為成分(2),可為至少1種生藥、至少2種生藥、至少3種生藥、或至少4種生藥。
薑黃為對薑黃(Curcuma longa L.)之根莖直接進行傳統漂燙或對去除軟木層後之物進行傳統漂燙並乾燥而得者,性味為溫、苦、辛,歸經為脾、肝,功效為破血行氣、通經止痛、祛風勝濕。主成分為精油、多酚、澱粉。
龍眼肉為將龍眼(Euphoria longana Lam)之假種皮乾燥而得者,性味為平、甘,歸經為心、脾,功效為養心血、安神、補脾氣。主成分為糖類、有機酸。
莪朮為對莪朮(Curcuma zedoaria Roscoe、Curcuma phaeocaulis Valeton、Curcuma Kwangsiensis S. G. Lee et C. F. Liang)之根莖進行傳統漂燙並乾燥而得者,性味為溫、苦、辛,歸經為肝、脾,功效為行氣破血、消積止痛。主成分為精油、多酚、澱粉。
雞血藤為將密花豆(Spatholobus suberectus Dunn)之蔓性莖乾燥而得者,性味為溫、苦、微甘,歸經為肝、腎,功效為活血補血、舒筋通絡。主成分為酚性化合物、鐵分、胺基酸。
絲瓜絡為將絲瓜(Luffa cylindrica (L.) M. Roem.)成熟果實之維管束乾燥而得者,性味為平、甘,歸經為肺、胃、肝,功效為行血通絡。主成分為多糖類、酚性化合物。
三棱為去除黑三棱(Sparganium stoloniferum (Graebn.) Buch.-Ham. ex Juz.)之塊莖之外皮並乾燥而得者,性味為平、苦,歸經為肝、脾,功效為破血行氣、消積止痛。主成分為精油、澱粉。
紅花為將紅花(Carthamus tinctorius L.)之管狀花直接壓榨或將去除大部分之黃色色素後之物有時壓榨而製成板狀者,性味為溫、辛,歸經為心、肝,功效為活血通經、祛瘀止痛。主成分為類黃酮。
劉寄奴為將奇蒿(Artemisia anomala S. Moore)之整株乾燥而得者,性味為溫、辛、苦,歸經為心、肝、脾、肺、腎、膀胱,功效為破血通經、消脹止痛、止血消腫、清熱利濕、下氣除脹。主成分為精油。
<成分(3)>
成分(3)係歸經為「肺」,性味為「涼」、「寒」或「微寒」之生藥,具體而言,為選自由茶葉、薄荷、桑葉、菊花及香鼓所組成之群中之至少1種。該等生藥中,就以較少之原料生藥量發揮效果之觀點而言,較佳為選自由茶葉、薄荷及桑葉所組成之群中之至少1種,就風味之觀點而言,更佳為選自由茶葉及桑葉所組成之群中之至少1種。作為成分(3),可為至少1種生藥、至少2種生藥、至少3種生藥、或至少4種生藥。
茶葉為將茶(Camellia sinensis (L.) Kuntze)之葉(通常帶有枝尖)乾燥而得者,性味為微寒、苦、微甘,歸經為心、肺、肝、腎、脾、胃,功效為祛風、清爽頭目、清熱降火、解暑、解熱毒、止瀉、利水。主成分為生物鹼、類黃酮、單寧。
薄荷為將薄荷(Mentha arvensis L. var. piperascens Malinv.)之地上部分乾燥而得者,性味為涼、辛,歸經為肺、肝,功效為疏散風熱、清頭目、利咽喉、透疹止癢、疏肝解鬱、辟穢。主成分為精油。
桑葉為將白桑(Morus alba L.)之葉乾燥而得者,性味為寒、苦、甘,歸經為肺、肝,功效為疏散風熱、清肺潤燥、止咳、平肝陽、明目。主成分為類黃酮、礦物質。
菊花為將杭菊(Chrysanthemum morifolium Ramat.)或寒菊(Chrysanthemum indicum L.)之頭花乾燥而得者,性味為涼、甘、微苦,歸經為肺、肝,功效為疏散風熱、明目、平肝陽。主成分為類黃酮、倍半萜。
香鼓為將大豆(Glycine max (L.) Merr. subsp. Max)之成熟種子蒸製醱酵並乾燥而得者,性味為涼、辛、甘、微鹹,歸經為肺、胃,功效為疏散解表、宣鬱除煩。主成分為脂肪、蛋白質。
<成分(4)>
成分(4)係歸經為「腎」、「脾」或「胃」之生藥,具體而言,為選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、蔥白、酸棗仁、柏子仁、車前子、車前草、薏苡仁、玉米鬚、地膚子、冬瓜子、扁蓄、金錢草、肉桂、乾薑、小茴香、蜀椒、胡椒、刺五加及艾葉所組成之群中之至少2種。成分(4)為產生氣,並具有使與抵抗力、虛弱相關之中焦溫暖之作用之生藥。若僅調配1種構成成分(4)之生藥,則溫中焦之作用有限,與成分(3)拮抗,無法充分發揮本發明之效果,但藉由調配2種構成成分(4)之生藥可充分溫中焦,可期待與其他成分之作用協同地作用,來發揮本發明之效果。再者,所謂中焦為三焦之一,於中國醫學中,認為三焦並非單一之形態器官,而為一個功能單位,分為:「上焦」,其指橫膈膜以上之胸部;「中焦」,其指橫膈膜至肚臍之間之腹部;及「下焦」,其指胃以下之部位。中焦係包含脾、胃,藉由參與營養物之消化、運輸而產生氣,成為抵抗力之源泉,並且與虛弱相關之三焦。
該等生藥中,就容易獲取(供給穩定性)之觀點而言,較佳為選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、車前子、車前草、薏苡仁、玉米鬚、地膚子、肉桂、乾薑、小茴香及刺五加所組成之群中之至少2種,就功效之觀點而言,更佳為選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、肉桂、乾薑、小茴香及刺五加所組成之群中之至少2種,尤佳為選自由補骨脂、蓽撥、肉桂、乾薑及刺五加所組成之群中之至少2種。作為成分(4),可為至少2種、至少3種、至少4種、或至少5種生藥。
又,就製品加工容易性之觀點而言,成分(4)較佳為選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、芫荽、車前草、薏苡仁、玉米鬚、地膚子、肉桂、小茴香及刺五加所組成之群中之至少2種(例如至少3種、至少4種、或至少5種生藥)。
陳皮為行氣藥,為將溫州蜜柑(Citrus unshiu (Swingle) Marcow.)或椪柑(Citrus reticulata Blanco)之成熟果皮乾燥而得者,性味為溫、辛、苦,歸經為脾、肺,功效為理氣健脾、燥濕化痰。主成分為精油、類黃酮。
補骨脂為助陽藥,為將補骨脂(Psoralea corylifolia L.)之成熟果實乾燥而得者,性味為大溫、辛、苦、澀,歸經為腎、脾,功效為補腎壯陽、固精縮尿、溫脾止瀉、溫腎納氣、平喘。主成分為精油、有機酸、類黃酮。
木瓜為祛風濕藥,為將榠櫨(Chaenomeles sinensis (Thouin) Koehne)或長春木瓜(Chaenomeles speciosa (Sweet) Nakai)之接近成熟或已成熟之附果乾燥而得者,性味為溫、酸,歸經為肝、脾,功效為平肝舒筋、和中祛濕。主成分為皂苷、有機酸、單寧。
蓽撥為散寒藥,為將印度長胡椒(Piper longum L.)之接近成熟或成熟果穗乾燥而得者,性味為熱、辛,歸經為胃、大腸,功效為溫中散寒,行氣止痛。主成分為精油、生物鹼。
桂枝為辛溫解表藥,為將肉桂(Cinnamomum cassia Blume)之小枝乾燥而得者,性味為溫、辛、甘,歸經為肺、心、脾、肝、腎、膀胱,功效為發汗解肌、溫通經脈、通陽化氣、平衡降逆。主成分為精油、單寧。
紫蘇為辛溫解表藥,為將紫蘇(Perilla frutescens (L.) Britton var. crispa (Benth.) W. Deane)之葉及枝尖乾燥而得者,性味為溫、辛,歸經為肺、脾、胃,功效為散寒解表、理氣寬中、行氣安胎、解魚蟹毒。主成分為精油、花青素糖苷、類黃酮。
生薑為辛溫解表藥,為將生薑(Zingiber officinale Roscoe)之根莖有時去除周皮後之物乾燥而得者,性味為微溫、辛,歸經為肺、脾、胃,功效為散寒解表、溫胃止嘔、化痰行水、解毒。主成分為精油、辛辣成分、澱粉。
芫荽為辛溫解表藥,為將胡荽(Coriandrum sativum L.)之整株乾燥而得者,性味為溫、辛,歸經為肺、胃,功效為解表透疹、開胃消食。主成分為精油、萜烯。
蔥白為辛溫解表藥,為將蔥(Allium fistulosum L.9之鱗莖乾燥而得者,性味為溫、辛,歸經為肺、胃,功效為散寒解表、通陽散寒。主成分為精油、含硫化合物。
酸棗仁為養心安神藥,為將酸棗(Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H.F.Chow)之成熟種子乾燥而得者,性味為平、甘、酸,歸經為心、肝、膽、脾,功效為補肝寧心、收斂止汗。主成分為三萜、皂苷、類黃酮。
柏子仁為養心安神藥,為將側柏(Platycladus orientalis (L.) Franco)之成熟種子乾燥並去除種皮而得者,性味為平、甘,歸經為心、脾、肝、腎,功效為養心安神、益陰止汗、益脾潤腸。主成分為脂肪油、皂苷。
車前子為利水滲濕藥,為將車前草(Plantago asiatica L.)之成熟種子乾燥而得者,性味為寒、甘、淡,歸經為肝、腎、肺、小腸,功效為清熱利水、滲濕止瀉、清肝明目、化痰止咳。主成分為黏液性多糖類、環烯醚萜苷。
車前草為利水滲濕藥,為將車前(Plantago asiatica L.)之花期之整株乾燥而得者,性味為寒、甘、淡,歸經為肝、腎、肺、小腸,功效為清熱利水、滲濕止瀉、清肝明目、化痰止咳。主成分為環烯醚萜苷、類黃酮。
薏苡仁為利水滲濕藥,為將薏苡(Coix lacryma-jobi var. ma-yuen (Rom.Caill.) Stapf)之成熟種子乾燥並去除種皮而得者,性味為微寒、甘、淡,歸經為脾、胃、肺,功效為清利濕熱、祛濕舒筋除痺、排膿消腫、健脾止瀉。主成分為澱粉、蛋白質。
玉米鬚為利水滲濕藥,為將玉米(Zea mays L.)之花柱乾燥而得者,性味為平、甘,歸經為肝、腎、膀胱、心、小腸,功效為利水消腫、退黃。主成分為皂苷、類黃酮。
地膚子為利水滲濕藥,為將地膚(Kochia scoparia (L.) Schrad.)之成熟果實乾燥而得者,性味為寒、辛、苦,歸經為腎、膀胱,功效為清濕熱、利小便、祛風止癢。主成分為三萜皂苷。
冬瓜子為利水滲濕藥,為將冬瓜(Benincasa cerifera Savi)或Benincasa cerifera Savi forma emarginata K. Kimura et Sugiyama之成熟種子乾燥而得者,性味為微寒、甘,歸經為肺、胃、大腸、小腸,功效為清熱、利水消腫。主成分為脂肪酸、生物鹼。
扁蓄為利水滲濕藥,為將萹蓄(Polygonum aviculare L.)之地上部分乾燥而得者,性味為平、苦,歸經為胃、膀胱,功效為利水通淋、殺蟲止癢。主成分為黃酮苷、單寧。
金錢草為利水滲濕藥,為將金錢草(Lysimachia christinae Hance)之整株乾燥而得者,性味為微寒、甘、鹹、淡,歸經為肝、膽、腎、膀胱,功效為利水通淋、排石止痛、清熱祛濕、退黃。主成分為精油、單寧。
肉桂為散寒藥,為將肉桂(Cinnamomum cassia Blume)之樹皮或去除一部分周皮後之樹皮乾燥而得者,性味為大熱、辛、甘,歸經為肝、腎、心、脾、胃,功效為溫中補陽、散寒止痛、溫通經脈。主成分為精油、單寧。
乾薑為散寒藥,為將生薑(Zingiber officinale Roscoe)之根莖燙漂或蒸製並乾燥而得者,性味為大熱、大辛,歸經為心、肺、脾、胃,功效為溫中散寒、回陽通脈、溫肺化痰、化飲。主成分為精油、辛辣成分、澱粉。
小茴香為散寒藥,為將茴香(Foeniculum vulgare Mill.)之成熟果實乾燥而得者,性味為溫、辛,歸經為肝、腎、脾、胃,功效為散寒止痛、理氣和胃。主成分為精油。
蜀椒為散寒藥,為華北山椒(Zanthoxylum bungeanum Maxim.)或冬山椒(Zanthoxylum armatum DC. var. subtrifoliatum (Franch.) Kitam.)之成熟果皮,且儘可能去除經分離之種子並乾燥而得者,性味為熱、辛,歸經為脾、胃、腎,功效為散寒止痛、燥濕、解毒驅蟲。主成分為精油、辛辣成分。
胡椒為散寒藥,為將胡椒(Piper nigrum L.)之接近成熟或成熟果實乾燥而得者,性味為熱、辛,歸經為胃、大腸,功效為溫中散寒、行氣止痛。主成分為精油、生物鹼。
刺五加為祛風濕藥,為將刺五加(Eleutherococcus senticosus (Rupr. et Maxim.) Maxim.)之根、根莖乾燥而得者,性味為溫、辛、苦,歸經為肝、腎,功效為舒風濕、補肝腎、強筋骨、利水消腫。主成分為皂苷、木聚糖。
艾葉為散寒藥,為將艾蒿(Artemisia princeps Pamp.)或山地蒿(Artemisia montana (Nakai) Pamp.)之葉及枝尖乾燥而得者,性味為溫、苦、辛,歸經為肝、脾、腎,功效為散寒除濕、止痛、溫經止痛。主成分為精油、脂肪酸、單寧。
作為本實施方式之組合物中所含之成分(1)、成分(2)、成分(3)及成分(4)之生藥可為生藥本身,亦可為將生藥切碎或粉碎而得者,或者,亦可為生藥之萃取物。於本申請說明書中,生藥之萃取物較佳為利用製藥上可容許之水性溶劑,例如水(包括熱水)、乙醇或水與乙醇之混合溶劑對生藥進行提取而得者。生藥萃取物可為藉由公知之提取方法而製作者,亦可為一般之軟萃取物或萃取物粉末、萃取物顆粒。
作為本實施方式之組合物中所含之成分(1)、成分(2)、成分(3)及成分(4)之生藥之調配量可依據攝取者之體重、年齡、症狀等各種條件適當設定,只要為足以發揮氣虛及/或血虛相關症狀之預防、改善或緩和之量即可,以每日劑量之生藥之重量(於萃取物之情形時,為所使用之生藥之重量(生藥換算重量))(g/天)進行規定。
以各生藥之日劑量計,作為成分(1),可例舉:炙甘草3~6 g、甘草3~6 g、山藥9~30 g、大棗3~9 g、膠飴30~60 g及人參3~9 g。作為成分(2),可例舉:薑黃3~9 g、龍眼肉6~12 g、莪朮3~9 g、雞血藤9~15 g、絲瓜絡6~15 g、三棱3~9 g、紅花3~9 g及劉寄奴9~15。作為成分(3),可例舉:茶葉3~15 g、薄荷1.5~6 g、桑葉3~9 g、菊花6~12 g及香鼓9~15 g。作為成分(4),可例舉:陳皮3~9 g、補骨脂3~9 g、木瓜3~9 g、蓽撥1.5~6 g、桂枝3~10 g、紫蘇6~12 g、生薑3~9 g、芫荽3~6 g、蔥白3~9 g、酸棗仁9~15 g、柏子仁6~15 g、車前子3~9 g、車前草3~9 g、薏苡仁9~30 g、玉米鬚15~30 g、地膚子9~15 g、冬瓜子15~30 g、扁蓄9~30 g、金錢草15~30 g、肉桂1.5~5 g、乾薑3~9 g、小茴香3~9 g、蜀椒3~6 g、胡椒1.5~3 g、刺五加3~9 g及艾葉3~6 g。於使用多種生藥作為成分(1)、成分(2)、成分(3)、或成分(4)之情形時,各生藥之日劑量可適當減量。
本實施方式之組合物為氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物。本實施方式之組合物實現:藉由成分(1)作用於脾來生氣補氣,並且除所補之氣之作用以外,成分(2)有助於造血並使血液循環,藉此亦補血虛。進而,成分(4)產生氣並使與抵抗力、虛弱相關之中焦溫暖,藉此增強補氣之作用,並且,藉由成分(3)適當地獲取溫寒之平衡,且協同地表現精神穩定作用。如此,可藉由包括成分(1)、成分(2)、成分(3)及成分(4),來預防、改善或緩和氣虛及/或血虛相關各種症狀。
氣虛及/或血虛相關症狀為選自慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、失眠、睡眠障礙中之至少1種、至少2種、至少3種、至少4種或至少5種,尤佳為選自由慢性疲勞、易疲勞感、倦怠感、精力下降、失眠、睡眠障礙所組成之群中之至少1種、至少2種、至少3種、至少4種或至少5種。又,上述至少1種症狀較佳為持續1週以上、2週以上、4週以上、3個月以上、6個月以上或1年以上時間之症狀。
本實施方式之組合物較佳為食品組合物或醫藥組合物。本實施方式之組合物中所含之各生藥未收錄於日本藥典生藥等中,由於無使用限制,故而可用於醫療及食品兩者。因此,本實施方式之組合物可製成功能性食品等食品組合物。因此,具有無需醫師之處方就可輕鬆地預防、改善或緩和不適症狀或身體不適之優點。
食品組合物可為作為食品而可能之任意形態。例如,可例舉:乳製品;醱酵食品(酸乳酪、乾酪等);飲料類(如咖啡、果汁、茶飲料之清涼飲料、碳酸飲料、乳飲料、乳酸菌飲料、含乳酸菌飲料、酸乳飲料、如日本酒、果酒、洋酒之酒等);塗抹醬類(乳蛋糕乳脂等);糊類(水果泥等);西式點心類(甜甜圈、餡餅、奶油泡芙、口香糖、糖果、凍膠劑、曲奇、蛋糕、巧克力、布丁等);日式點心類(大福、年糕、日式甜饅頭、長崎蛋糕、餡蜜、羊羹等);冰點心類(冰淇淋、冰棒、果子露冰激淩等);食品類(咖喱、牛肉蓋飯、雜燴粥、粥、味噌湯、湯、肉醬、意麵、醃菜、果醬等);調味料類(調味醬、鮮味調味料、香松、湯料等)等。該食品組合物亦可於商業店鋪中作為菜肴提供,又,亦可採取預製食品、軟罐頭食品、冷凍食品、其他一般食品組合物之包裝形態等,以一般流通形態提供。
上述各種形態之食品組合物除作為有效成分之成分(1)、成分(2)、成分(3)、及成分(4)以外,只要不影響有效成分之作用,亦可包含作為食品所容許之成分。例如,可例舉:各種一般食材、澱粉、明膠、植物油脂、動物油脂、加工油脂等、羧甲基纖維素、阿拉伯樹膠、刺槐豆膠、黃耆膠、刺梧桐樹膠、魔芋葡甘露聚糖、三仙膠、瓊脂、鹿角菜膠、聚丙烯酸、角豆膠、海藻酸、環糊精等膠化劑、調味料、甜味料、香辛料、著色料、保存劑、抗氧化劑、水、清涼劑、結合劑、甜味料、崩解劑、潤滑劑、著色料、香料、穩定劑、防腐劑、緩釋調整劑、界面活性劑、溶解劑、濕潤劑等。
本實施方式之食品組合物可以進而發揮複合之效果為目的,適當任意地調配具有功能性之食品材料。例如,可適當任意地調配除成分(1)、成分(2)、成分(3)、及成分(4)以外之各種生藥、各種益生菌、各種寡醣、維生素、礦物質等營養成分、類黃酮類、醌類、多酚類、胺基酸、核酸、必需脂肪酸、其他公知之功能性食品材料。
各種形態之食品組合物之製法並無特別限定,可適當遵循公知之方法。又,亦可添加能夠減少生藥特有之味道及氣味之成分或對其進行處理。
本實施方式之食品組合物亦可為以保健、健康維持、健康促進等為目的之食品,例如健康食品、功能性標示食品、營養輔助食品、補充品、特定保健用食品或營養功能食品等。於本實施方式之食品組合物為補充品之情形時,例如可為錠劑、膠囊劑、顆粒劑、液劑、散劑、飲劑、凍膠劑等形態。本實施方式之食品組合物可直接攝取,亦可混入飲食、零食、飲料等中攝取。
本實施方式之食品組合物中之作為有效成分之成分(1)、成分(2)、成分(3)、及成分(4)之含量並無特別限定,又,亦視食品組合物之形態而異。例如,於食品組合物之形態為錠劑、膠囊劑、顆粒劑、液劑、散劑、棒狀凍膠劑等補充品形態之情形時,可例舉食品組合物中之各生藥之總重量典型地為該食品組合物之超過0~100重量%,例如10~80質量%。又,於食品組合物之形態為各種飲料、凍膠劑、食品類、軟罐頭食品類等一般食品形態之情形時,可例舉食品組合物中之各生藥之總重量典型地為該食品組合物之0.05~25質量%。若考慮味道或量,則較佳為將食品組合物中之有效成分之調配量抑制至最低限度,於此情形時,相較於直接使用生藥進行調配,較佳為使用生藥萃取物。由於本實施方式之食品組合物中所含之生藥為通常用作食品之作用緩和者,故而其攝取量並無特別限定。若本實施方式之食品組合物之攝取量為包括上述生藥之日劑量之量,則可獲得所需之氣虛及/或血虛相關症狀之預防、改善或緩和效果。
本實施方式之醫藥組合物可為飲劑、糖漿、凍膠劑、凍乾粉、錠劑、膠囊劑、丸劑、散劑、細粒劑、顆粒劑等劑型,又,除作為有效成分之成分(1)、成分(2)、成分(3)、及成分(4)以外,例如亦可包括藥學上可容許之成分,例如賦形劑、結合材料、潤滑劑、崩解劑、乳化劑、界面活性劑、基劑、增溶劑、懸浮劑。
本實施方式之組合物亦可與其他組合物併用。例如,可將本實施方式之組合物與用於治療氣虛及/或血虛相關症狀之非處方藥、例如維生素B群或肝臟水解物等併用,藉此由最低限度之非處方藥之使用來消除不適症狀。
組合物之攝取可為每日1次,亦可分為複數次,例如2次、3次或4次攝取。於複數次攝取之情形時,只要以每日之合計量為日劑量之方式攝取即可。本實施方式之組合物之攝取時機並無特別限定,於每日攝取1次之情形時,可於起床後、餐前、餐間、餐後、就寢前等任意時間攝取,於每日攝取複數次之情形時,可於起床後、餐前、餐間、餐後、就寢前中之2個、3個或4個以上時機攝取。又,亦可與飲食同時攝取。
本實施方式之組合物可持續1週以上、2週以上、4週以上、3個月以上、6個月以上或1年以上時間攝取。由於本實施方式之組合物為安全之生藥成分,故而即便長期攝取亦安全,並且,藉由長期服用,可逐漸改善體質並逐漸緩和或改善氣虛及/或血虛相關症狀。
一實施方式之方法為包括將上述本實施方式之組合物施予給需要其之對象之步驟的、預防、改善或緩和氣虛及/或血虛相關症狀之方法。此處,對象為具有氣虛及/或血虛相關症狀之主觀察覺,或基於中國醫學診斷為氣虛及/或血虛之對象。組合物以上述日劑量施予(例如投予)對象。投予時間並無特別限定,可為1週以上、2週以上、4週以上、3個月以上、6個月以上或1年以上。
一實施方式之組合物為氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物,該組合物可為上述本實施方式之組合物。此處,使用方法(攝取量、攝取時間)如上所述。
一實施方式之用途為上述本實施方式之組合物之用途,其係用於製造氣虛及/或血虛相關症狀之預防、改善或緩和用之組合物。又,另一實施方式之用途為上述本實施方式之組合物之用途,其係用於氣虛及/或血虛相關症狀之預防、改善或緩和。此處,使用方法(攝取量、攝取時間)如上所述。組合物可為食品組合物或醫藥組合物,該組合物可以包含有效量之成分(1)、成分(2)、成分(3)及成分(4)之生藥或生藥萃取物之方式按照常規方法製造,如有需要,亦可使其包含上述其他成分。
以下,為進一步詳細地說明本發明而例舉實施例。然而,本發明不受該等實施例等任何限定。
[實施例]
<試驗例1>
(對氣虛及/或血虛相關身體不適造成影響之評估試驗)
對主觀察覺氣虛及/或血虛相關日常身體不適之18歲以上64歲以下之日本男女19人(實施例1)、18人(實施例2及比較例1)或14人(實施例3)實施單盲前後比較試驗,研究本發明之效果。
(組合物)
實施例1、實施例2、實施例3及比較例1之生藥組成及單次使用量示於表1中。按照作為原料生藥記載於表2中之生藥之單次量之比例調配原料生藥,用常水進行沸騰提取,並進行過濾、濃縮、殺菌,添加適量糊精後利用噴霧乾燥器進行乾燥,獲得混合植物萃取物粉末。將所得之萃取物中與作為原料生藥記載於表2中之生藥量相當之實施例1之萃取物粉末6.0 g、實施例2之萃取物粉末15.0 g、實施例3之萃取物粉末7.2 g或比較例1之萃取物粉末6.0 g製成1天量之食品組合物。
[表1]
成分(1)/g | 成分(2)/g | 成分(3)/g | 成分(4)/g | |
實施例1 | 炙甘草/3 | 薑黃/3 | 茶葉/3 | 陳皮/3 補骨脂/3 木瓜/3 蓽撥/1.5 刺五加/3 |
實施例2 | 膠飴/10 山藥/9 | 莪朮/3 | 菊花/6 | 乾薑/3 芫荽/3 |
實施例3 | 山藥/9 炙甘草/3 | 紅花/3 | 薄荷/1.5 | 紫蘇/6 肉桂/3 薏苡仁/9 玉米鬚/15 |
比較例1 | 膠飴/3 | 莪朮/3 | 菊花/6 | 乾薑/3 |
使受驗者連續2週(14天)每日1次於早餐前將實施例1、2、3或比較例1之萃取物粉末之日劑量(實施例1:2.0 g、實施例2:5.0 g、實施例3:2.4 g、比較例1:2.0 g)溶解於約150 cc之熱水中攝取。於攝取前及攝取2週結束時,以所有受驗者為對象實施不適症狀問卷調查,評估症狀之改善度。攝取前之不適症狀問卷調查針對表2中記載之症狀群之各者設定「感受強烈(1)」、「稍有感受(2)」、「未感受到(3)」之3個等級之評分,評估有無主觀察覺各症狀。攝取結束時之不適症狀問卷調查針對表2中記載之症狀群之各者,設定「明顯好轉(1)」、「有所好轉(2)」、「無變化(3)」、「有所惡化(4)」、「明顯惡化(5)」之5個等級之評分,評估各症狀有無改善。將攝取前問卷調查之評分為1或2之受驗者中攝取結束時問卷調查之評分為4或5之受驗者之比率(%)作為改善率,並將改善率為10%以上之不適症狀判定為該萃取物具有改善效果,將改善率為30%以上之不適症狀判定為該萃取物具有顯著之改善效果。
(結果)
將結果示於表2中。根據表2,與攝取了含有包含1種生藥之成分(1)、包含1種生藥之成分(2)及包含1種生藥之成分(3)、且僅含有1種構成成分(4)之生藥之比較例1之生藥萃取物之受驗者相比,於攝取了含有包含1種生藥之成分(1)、包含1種生藥之成分(2)、包含1種生藥之成分(3)及包含5種生藥之成分(4)之實施例1、含有包含2種生藥之成分(1)、包含1種生藥之成分(2)、包含1種生藥之成分(3)及包含2種生藥之成分(4)之實施例2、或含有包含2種生藥之成分(1)、包含1種生藥之成分(2)、包含1種生藥之成分(3)及包含4種生藥之成分(4)之實施例3之生藥萃取物之受驗者中,可觀察到慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、失眠、睡眠障礙之改善。除上述效果以外,藉由攝取實施例1之生藥萃取物,可觀察到乏力感、食慾不振、腹瀉、尿失禁、頻尿、四肢冰冷、怕冷、易感染性、多汗、面色不佳之改善,藉由攝取實施例2之生藥萃取物,可觀察到乏力感、腹瀉、頻尿之改善,藉由攝取實施例3之生藥萃取物,可觀察到怕冷之改善。即,基於成分(1)、成分(2)、成分(3)及成分(4)之協同作用,於氣虛及/或血虛相關所有症狀中可確認到預防、改善或緩和效果。
[表2]
群 | 項目 | 慢性疲勞 | 易疲勞、 易喘息(易疲勞感) | 身體沉重、疲倦(倦怠感) | 身體、手腳麻木、 乏力感 | 精力下降 | 無食慾、胃灼熱 (食慾不振) | 腹瀉 | 尿量較少(尿量異常) | 漏尿(尿失禁) | 排尿次數較多(頻尿) | 手腳發冷(四肢冰冷感) | 體溫較低(發冷) | 易身體狀況不佳 | 易感冒(易感染性) | 感冒之症狀(惡寒 、鼻涕、咳嗽) | 睡眠差(失眠) | 睡眠較淺 、半夜醒來(睡眠障礙) | 盜汗較多 | 多汗 | 面色慘白(面色不佳) |
實施例 1 | 改善率(%) | 47 | 58 | 50 | 50 | 17 | 33 | 25 | 50 | 25 | 20 | 13 | 25 | 33 | 20 | 17 | 40 | 56 | 25 | 33 | 50 |
改善 | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ○ | ||||||||||||
實施例 2 | 改善率(%) | 36 | 20 | 33 | 33 | 27 | 0 | 25 | 100 | 0 | 50 | 0 | 0 | 0 | 0 | 0 | 38 | 33 | 0 | 0 | 0 |
改善 | ○ | ○ | ○ | ||||||||||||||||||
實施例 3 | 改善率(%) | 23 | 11 | 20 | 0 | 13 | 0 | 0 | 100 | 0 | 0 | 0 | 50 | 0 | 0 | 0 | 43 | 20 | 0 | 0 | 0 |
改善 | ○ | ○ | ○ | ○ | ○ | ||||||||||||||||
比較例 1 | 改善率(%) | 25 | 9 | 25 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 29 | 13 | 0 | 0 | 0 |
改善 | ○ | ○ | ○ | ○ | |||||||||||||||||
-:對實施例1不實施該問卷調查 :有顯著之改善效果 ○:有改善效果 |
Claims (4)
- 一種組合物,其包含下述之成分(1)、成分(2)、成分(3)及成分(4)作為有效成分: 成分(1):選自由炙甘草、甘草、山藥、大棗、膠飴及人參所組成之群中之至少1種生藥; 成分(2):選自由薑黃、龍眼肉、莪朮、雞血藤、絲瓜絡、三棱、紅花及劉寄奴所組成之群中之至少1種生藥; 成分(3):選自由茶葉、薄荷、桑葉、菊花及香鼓所組成之群中之至少1種生藥; 成分(4):選自由陳皮、補骨脂、木瓜、蓽撥、桂枝、紫蘇、生薑、芫荽、蔥白、酸棗仁、柏子仁、車前子、車前草、薏苡仁、玉米鬚、地膚子、冬瓜子、扁蓄、金錢草、肉桂、乾薑、小茴香、蜀椒、胡椒、刺五加及艾葉所組成之群中之至少2種生藥。
- 如請求項1之組合物,其用於預防、改善或緩和氣虛及/或血虛相關症狀。
- 如請求項2之組合物,其中氣虛及/或血虛相關症狀為選自由慢性疲勞、易疲勞感、倦怠感、精力下降、尿量異常、頻尿、失眠、及睡眠障礙所組成之群中之至少1種。
- 如請求項1至3中任一項之組合物,其係食品組合物或醫藥組合物。
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