TW202327654A - 含有il-31拮抗劑作為有效成分之異位性皮膚炎的預防用及/或治療用醫藥組合物 - Google Patents
含有il-31拮抗劑作為有效成分之異位性皮膚炎的預防用及/或治療用醫藥組合物 Download PDFInfo
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| TW110129891A TWI826814B (zh) | 2015-04-14 | 2016-04-13 | 含有il-31拮抗劑作為有效成分之異位性皮膚炎的預防用及/或治療用醫藥組合物 |
| TW105111451A TWI738648B (zh) | 2015-04-14 | 2016-04-13 | 含有ｉｌ－３１拮抗劑作為有效成分之異位性皮膚炎的預防用及／或治療用醫藥組合物 |
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| TW105111451A TWI738648B (zh) | 2015-04-14 | 2016-04-13 | 含有ｉｌ－３１拮抗劑作為有效成分之異位性皮膚炎的預防用及／或治療用醫藥組合物 |
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| WO2017126488A1 (ja) * | 2016-01-18 | 2017-07-27 | 持田製薬株式会社 | 乾癬治療用組成物および治療方法 |
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| SG11202007558YA (en) * | 2018-02-09 | 2020-09-29 | Nestle Skin Health Sa | Nemolizumab in the treatment of atopic dermatitis with moderate to severe excoriation |
| TWI840360B (zh) | 2018-05-21 | 2024-05-01 | 日商中外製藥股份有限公司 | 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器 |
| WO2020142625A2 (en) * | 2019-01-03 | 2020-07-09 | Invetx Inc. | Compositions for increasing half-life of a therapeutic agent in canines and methods of use |
| BR112022002771A2 (pt) * | 2019-08-29 | 2022-08-09 | Kindred Biosciences Inc | Anticorpos anti-il31 para uso veterinário |
| CN110563844A (zh) * | 2019-09-04 | 2019-12-13 | 华中农业大学 | 一种抗犬白介素31受体的多克隆抗体及其应用 |
| CA3156713A1 (en) | 2019-11-20 | 2021-05-27 | Daisuke Kameoka | Antibody-containing preparation |
| US20230047844A1 (en) * | 2020-01-24 | 2023-02-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Compounds and methods for treating or reducing pruritus |
| WO2022113316A1 (ja) * | 2020-11-30 | 2022-06-02 | マルホ株式会社 | 線維化の進行抑制剤 |
| TW202304510A (zh) * | 2021-04-07 | 2023-02-01 | 瑞士商葛德瑪控股公司 | 結節性癢疹之治療 |
| CN115181183B (zh) * | 2022-06-23 | 2023-11-03 | 恺佧生物科技(上海)有限公司 | 一种il-31ra抗体以及其构建方法 |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH575014A5 (enrdf_load_html_response) | 1973-05-25 | 1976-04-30 | Alusuisse | |
| JPS5328498Y2 (enrdf_load_html_response) | 1973-08-17 | 1978-07-18 | ||
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| BR9204244A (pt) | 1992-10-26 | 1994-05-03 | Cofap | Ferro fundido cinzento |
| FI952658A0 (fi) | 1992-12-01 | 1995-05-31 | Protein Design Labs Inc | L-selektiinin kanssa reaktiivisia humanisoituja vasta-aineita |
| FR2729855A1 (fr) | 1995-01-26 | 1996-08-02 | Oreal | Utilisation d'un antagoniste de cgrp dans une composition cosmetique, pharmaceutique ou dermatologique et composition obtenue |
| US5876950A (en) | 1995-01-26 | 1999-03-02 | Bristol-Myers Squibb Company | Monoclonal antibodies specific for different epitopes of human GP39 and methods for their use in diagnosis and therapy |
| DE69633973T2 (de) | 1995-09-11 | 2005-12-22 | Kyowa Hakko Kogyo Co., Ltd. | Antikörper gegen die alpha-kette von humanem interleukin 5 rezeptor |
| EP0852951A1 (de) | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
| CN1241944A (zh) | 1996-12-05 | 2000-01-19 | 乔治敦大学 | 具有抗病毒活性的鼠尾草种类的提取物 |
| JPH11101542A (ja) | 1997-09-29 | 1999-04-13 | Sanyo Electric Co Ltd | 冷蔵庫 |
| AU764653B2 (en) | 1998-04-30 | 2003-08-28 | Tanox, Inc. | G-CSF receptor agonist antibodies and screening method therefor |
| FR2780062B1 (fr) | 1998-06-17 | 2000-07-28 | Rhone Poulenc Rorer Sa | Anticorps monoclonaux diriges contre la proteine g3bp, et leurs utilisations |
| CA2330547A1 (en) | 1998-06-24 | 1999-12-29 | Chugai Research Institute For Molecular Medicine, Inc. | Novel hemopoietin receptor proteins |
| AU776910B2 (en) | 1998-12-08 | 2004-09-23 | Merck Patent Gesellschaft Mit Beschrankter Haftung | Modifying protein immunogenicity |
| WO2000075314A1 (fr) | 1999-06-02 | 2000-12-14 | Chugai Research Institute For Molecular Medicine, Inc. | Proteine receptrice d'hemopoietine |
| ES2254224T3 (es) | 1999-09-27 | 2006-06-16 | Chugai Seiyaku Kabushiki Kaisha | Nueva proteina del receptor de hematopoyetina, nr12. |
| CN1326880A (zh) | 2000-06-06 | 2001-12-19 | 周伟中 | 双层站台火车站 |
| US20030096339A1 (en) | 2000-06-26 | 2003-05-22 | Sprecher Cindy A. | Cytokine receptor zcytor17 |
| ES2593002T3 (es) | 2000-06-26 | 2016-12-05 | Zymogenetics, Inc. | Receptor ZCYTOR17 de citocina |
| WO2002077230A1 (fr) | 2001-03-26 | 2002-10-03 | Chugai Seiyaku Kabushiki Kaisha | Variants d'epissage nr10 |
| EP1754719A3 (en) | 2001-04-05 | 2007-05-16 | Immuno-Biological Laboratories Co., Ltd. | Anti-osteopontin antibody and use thereof |
| JP4795641B2 (ja) | 2002-01-18 | 2011-10-19 | ザイモジェネティクス， インコーポレイテッド | 新規サイトカインｚｃｙｔｏｒ１７リガンド |
| AU2003280410B8 (en) | 2002-01-18 | 2009-04-23 | Zymogenetics, Inc. | Cytokine receptor zcytor17 multimers |
| DK1485477T3 (da) | 2002-02-25 | 2009-08-10 | Genentech Inc | Hidtil ukendt type-1-cytokinreceptor GLM-R |
| CN100563709C (zh) | 2002-05-01 | 2009-12-02 | 舍林股份公司 | 作为抗凝剂的新的靶向组织因子的抗体 |
| US7579000B2 (en) | 2002-05-01 | 2009-08-25 | Bayer Schering Pharma Ag | Tissue factor targeted antibodies as anticoagulants |
| TW200407335A (en) | 2002-07-22 | 2004-05-16 | Chugai Pharmaceutical Co Ltd | Non-neutralizing antibody to inhibit the inactivation of activated protein C |
| KR100499989B1 (ko) | 2002-12-27 | 2005-07-07 | 네오바이오다임 주식회사 | 아사이알로 α1-산 당단백질에 대한 단일클론 항체, 이 항체를 포함하는 아사이알로 α1-산 당단백질에 대한 단일클론 항체, 이 항체를 포함하는 면역크로마토그래피 스트립 및 이 스트립를 이용한 아사이알로 α1-산 당단백질 측정방법 |
| US20040223970A1 (en) | 2003-02-28 | 2004-11-11 | Daniel Afar | Antibodies against SLC15A2 and uses thereof |
| AU2004229311B2 (en) | 2003-03-04 | 2009-07-09 | Alexion Pharmaceuticals, Inc. | Method of treating autoimmune disease by inducing antigen presentation by tolerance inducing antigen presenting cells |
| CA2519057A1 (en) | 2003-03-24 | 2004-10-07 | Zymogenetics, Inc. | Anti-il-20 antibodies and binding partners and methods of using in inflammation |
| ZA200606461B (en) | 2004-02-12 | 2008-02-27 | Lexicon Pharmaceuticals Inc | Gene disruptions, compositions and methods relating thereto |
| KR100624013B1 (ko) | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
| AU2005259992A1 (en) | 2004-06-25 | 2006-01-12 | Medimmune, Llc | Increasing the production of recombinant antibodies in mammalian cells by site-directed mutagenesis |
| EP1671642A1 (en) | 2004-12-15 | 2006-06-21 | Universite D'angers | Compositions comprising (ant)agonists of oncostatin M (OSM), IL-31 and IFN-gamma for modulating keratinocyte migration and functions via a receptor containing OSMRbeta as a subunit, and applications thereof. |
| NO346624B1 (no) | 2004-12-28 | 2022-11-07 | Univ Di Genova | Monoklonale antistoff mot NKG2A |
| EP1848737B1 (en) | 2005-01-28 | 2016-05-18 | ZymoGenetics, Inc. | Homogeneous preparations of il-31 |
| AU2006214404B2 (en) | 2005-02-14 | 2012-03-08 | Bristol-Myers Squibb Company | Methods of treating skin disorders using an IL-31RA antagonist |
| US20060188499A1 (en) | 2005-02-14 | 2006-08-24 | Leung Donald Y | Methods of treating diseases which are mediated by cutaneous lymphocyte antigen positive cells |
| PE20061323A1 (es) | 2005-04-29 | 2007-02-09 | Rinat Neuroscience Corp | Anticuerpos dirigidos contra el peptido amiloide beta y metodos que utilizan los mismos |
| US8003108B2 (en) | 2005-05-03 | 2011-08-23 | Amgen Inc. | Sclerostin epitopes |
| ES2561628T3 (es) | 2005-05-06 | 2016-02-29 | Zymogenetics, Inc. | Anticuerpos monoclonales IL-31 y métodos de uso |
| EP1991581A2 (en) | 2006-01-10 | 2008-11-19 | Zymogenetics, Inc. | Methods of treating pain and inflammation in neuronal tissue using il-31 antagonists |
| EP3101033B1 (en) | 2006-01-12 | 2019-01-02 | Alexion Pharmaceuticals, Inc. | Antibodies to ox-2/cd200 and uses thereof |
| JP5033868B2 (ja) | 2006-03-23 | 2012-09-26 | バイオアークティック ニューロサイエンス アーベー | 改良型プロトフィブリル選択的抗体及びその使用 |
| DK2047863T3 (da) | 2006-06-08 | 2013-09-16 | Chugai Pharmaceutical Co Ltd | Middel til forebyggelse eller behandling af inflammatoriske sygdomme |
| EP2032602B1 (en) | 2006-06-15 | 2013-03-27 | The Board of Trustees of the University of Arkansas | Monoclonal antibodies that selectively recognize methamphetamine and methamphetamine like compounds |
| WO2008028192A2 (en) | 2006-09-01 | 2008-03-06 | Zymogenetics, Inc. | Variable region sequences of il-31 monoclonal antibodies and methods of use |
| EP2089057A2 (en) | 2006-12-11 | 2009-08-19 | Wyeth | Methods and compositions for treating and monitoring treatment of il-13-associated disorders |
| CN101600456A (zh) * | 2006-12-11 | 2009-12-09 | 惠氏公司 | 治疗il-13相关疾病和监测il-13相关疾病治疗的方法和组合物 |
| DE602008004296D1 (de) | 2007-02-14 | 2011-02-17 | Vaccinex Inc | Humanisierte anti-cd100-antikörper |
| JP2010518856A (ja) | 2007-02-23 | 2010-06-03 | シェーリング コーポレイション | 操作された抗−ＩＬ−２３ｐ１９抗体 |
| EP2138576A4 (en) | 2007-03-16 | 2011-02-23 | Kyowa Hakko Kirin Co Ltd | ANTI-CLAUDIN-4 ANTIBODY |
| GB0708002D0 (en) | 2007-04-25 | 2007-06-06 | Univ Sheffield | Antibodies |
| JP2010531340A (ja) | 2007-07-10 | 2010-09-24 | エフ．ホフマン−ラ ロシュ アーゲー | 新規処方物 |
| ES2566957T3 (es) | 2007-09-26 | 2016-04-18 | Chugai Seiyaku Kabushiki Kaisha | Región constante de anticuerpo modificado |
| PE20091205A1 (es) | 2007-09-26 | 2009-09-09 | Chugai Pharmaceutical Co Ltd | Anticuerpo anti-receptor de il-6 |
| JP5334319B2 (ja) | 2007-09-26 | 2013-11-06 | 中外製薬株式会社 | Ｃｄｒのアミノ酸置換により抗体の等電点を改変する方法 |
| JP5682995B2 (ja) | 2007-12-05 | 2015-03-11 | 中外製薬株式会社 | 抗ｎｒ１０抗体、およびその利用 |
| KR101595134B1 (ko) | 2007-12-05 | 2016-02-17 | 추가이 세이야쿠 가부시키가이샤 | 소양증 치료제 |
| ES2570853T3 (es) | 2007-12-07 | 2016-05-20 | Zymogenetics Inc | Moléculas de anticuerpo humanizadas específicas para IL-31 |
| KR20160062207A (ko) * | 2008-12-05 | 2016-06-01 | 추가이 세이야쿠 가부시키가이샤 | 항ｎｒ１０ 항체 및 그의 이용 |
| JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
| WO2010148253A2 (en) | 2009-06-17 | 2010-12-23 | Zystor Therapeutics, Inc. | Formulations for lysosomal enzymes |
| EP2735315B1 (en) | 2011-07-19 | 2019-10-02 | Chugai Seiyaku Kabushiki Kaisha | Stable protein-containing preparation containing argininamide or valinamide |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| SI2892927T1 (sl) | 2012-09-07 | 2018-10-30 | Regeneron Pharmaceuticals,Inc | Metode zdravljenja atopijskega dermatitisa z dajanjem antagonista Il-4R |
| US9198898B2 (en) * | 2013-06-24 | 2015-12-01 | Tigercat Pharma, Inc. | Use of NK-1 receptor antagonists in pruritus |
| JP5650871B1 (ja) * | 2013-06-28 | 2015-01-07 | 中外製薬株式会社 | そう痒を伴う疾患に罹患した患者のｉｌ−３１アンタゴニストによる治療に対する応答を予測する方法 |
| TW202327654A (zh) | 2015-04-14 | 2023-07-16 | 日商中外製藥股份有限公司 | 含有il-31拮抗劑作為有效成分之異位性皮膚炎的預防用及/或治療用醫藥組合物 |
| WO2018156367A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
| GB201703063D0 (en) | 2017-02-24 | 2017-04-12 | Arecor Ltd | Stabilized antibody protein solutions |
| WO2018191414A1 (en) | 2017-04-11 | 2018-10-18 | Kiniksa Pharmaceuticals, Ltd. | Stable anti-osmr antibody formulation |
| TWI840360B (zh) | 2018-05-21 | 2024-05-01 | 日商中外製藥股份有限公司 | 密封於玻璃容器之凍結乾燥的製劑、套組、製造凍結乾燥製劑的方法、防止或減低凍結乾燥製劑的玻璃容器成霧的方法、及容器內面經過硫酸銨處理或ｖｉｓｔ處理之玻璃容器 |
| CA3156713A1 (en) | 2019-11-20 | 2021-05-27 | Daisuke Kameoka | Antibody-containing preparation |
| JP6799831B1 (ja) | 2020-09-01 | 2020-12-16 | 中外製薬株式会社 | Ｉｌ−３１アンタゴニストを有効成分として含有する、透析そう痒症の予防用及び／又は治療用医薬組成物 |
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