TW202320731A - 清洗組成物及其製造方法 - Google Patents
清洗組成物及其製造方法 Download PDFInfo
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Abstract
本發明提供一種能夠抑制蛋白質分解酶、脂質分解酶的酶活性的降低,且使用性亦優異的清洗組成物。
本發明的清洗組成物含有:
(A)高級脂肪酸及/或其鹽;
(B)蛋白質分解酶及/或脂質分解酶;
(C)多元醇;以及
(D)水;
上述(C)的含量,相對於清洗組成物總量,為25~60質量%;
上述(D)的含量,相對於清洗組成物總量,為5~30質量%;
含有甘油及/或山梨醇作為上述(C);
上述甘油及/或山梨醇的含量,相對於清洗組成物總量,為10~60質量%。
Description
本發明係關於清洗組成物。更詳細而言,係關於能夠抑制蛋白質分解酶、脂質分解酶的活性降低,且穩定地保持該分解酶的活性之清洗組成物及其製造方法。
以往,以去除源自角質、汗腺分泌物等皮膚的髒污為目的,有人提出摻合了酶之清洗組成物。例如,專利文獻1中,揭示摻合了源自微生物的蛋白質分解酶之潔顏粉。
〔先前技術文獻〕
〔專利文獻〕
專利文獻1:日本特開2009-256211號公報
〔發明所欲解決之課題〕
蛋白質分解酶等酶,若在水的存在下保存一定時間則酶活性會降低或失去活性。在清洗組成物中,為了維持酶活性,通常必須極度減少清洗組成物所含之水的含量。然而,若極度減少清洗組成物所含之水的含量,則使用性會有問題。有例如清洗組成物與水的親和性降低,使用時的水溶性惡化之傾向、填充於管型的容器時的吐出性降低之傾向等使用性會有問題。另一方面,為了防止酶失去活性,亦有例如將粉末狀的潔顏料作成1次使用量的包裝之產品規格,但亦有許多以容納於管型的容器等形式方以便使用這樣的需求。
因此,本發明提供能夠抑制酶活性的降低,且使用性亦優異的清洗組成物。
〔解決課題之手段〕
本案發明人鑑於上述事情而重複仔細研究的結果,意外地發現:與蛋白質分解酶、脂質分解酶一起摻合高級脂肪酸及/或其鹽、特定的多元醇、及水,將該多元醇及水的含量控制在特定範圍,藉此能夠提供能夠抑制蛋白質分解酶、脂質分解酶的酶活性的降低,且使用性亦優異的清洗組成物。
即,本發明提供以下[1]~[10]。
[1]一種清洗組成物,其含有:(A)高級脂肪酸及/或其鹽、(B)蛋白質分解酶及/或脂質分解酶、(C)多元醇、以及(D)水;上述(C)的含量,相對於清洗組成物總量,為25~60質量%;上述(D)的含量,相對於清洗組成物總量,為5~30質量%;含有甘油及/或山梨醇作為上述(C);上述甘油及/或山梨醇的含量,相對於清洗組成物總量,為10~60質量%。
[2]如[1]記載之清洗組成物,其中上述(A)為碳數12~18的高級脂肪酸及/或其鹽。
[3]如[1]或[2]記載之清洗組成物,其中上述(B)為未固定化之狀態的蛋白質分解酶及/或脂質分解酶。
[4]如[1]至[3]中任一項記載之清洗組成物,其中上述(B)為鹼性蛋白質分解酶及/或鹼性脂質分解酶。
[5]如[1]至[4]中任一項記載之清洗組成物,其含有甘油作為上述(C)。
[6]如[1]至[5]中任一項記載之清洗組成物,其中上述(D)的含量,相對於清洗組成物總量,為15~30質量%。
[7]如[1]至[6]中任一項記載之清洗組成物,其進一步含有(E)pH調整劑。
[8]如[1]至[7]中任一項記載之清洗組成物,其中清洗組成物的pH為8.0~12.0。
[9]如[1]至[8]中任一項記載之清洗組成物,其係填充於管型的容器。
[10]一種如[1]至[8]中任一項記載之清洗組成物之製造方法,其具有以下步驟:在含有加熱至60℃以上之上述(C)與(D)之相I中,添加含有在60~80℃加熱溶解之(A)之相II並攪拌後,經過冷卻步驟,在55℃以下添加(B)。
〔發明的效果〕
根據本發明,能夠提供能夠抑制酶活性的降低,且使用性亦優異的清洗組成物。
針對本發明的實施形態詳細地說明。但是,本發明未限定於以下的實施形態。
本說明書中使用「X~Y」(X、Y為任意數字)記載之數值範圍,只要未特別說明,則意指「X以上Y以下」。本說明書中階段性地記載之數值範圍,能夠將某一階段的數值範圍的上限值或下限值,與另一階段的數值範圍的上限值或下限值任意地組合。又,本說明書中記載之數值範圍中,其數值範圍的上限值或下限值,亦能夠置換為實施例或製劑例所示之值。
又,本說明書中「α及/或β」(α、β為任意構成或成分),只要未特別說明,則意指「僅α」、「僅β」、「α及β兩者」的3種組合。
<清洗組成物>
本發明的實施形態之清洗組成物,含有(A)高級脂肪酸及/或其鹽、(B)蛋白質分解酶及/或脂質分解酶、(C)多元醇、以及(D)水;上述(C)的含量,相對於清洗組成物總量,為25~60質量%;上述(D)的含量,相對於清洗組成物總量,為5~30質量%;含有甘油及/或山梨醇作為上述(C);上述甘油及/或山梨醇的含量,相對於清洗組成物總量,為10~60質量%。
〔(A)高級脂肪酸及/或其鹽〕
本發明的實施形態之清洗組成物所使用之(A)成分,通常只要為外用組成物及/或化妝品所使用之高級脂肪酸及/或其鹽,則能夠沒有特別限制地使用。
就(A)成分而言,可列舉例如:碳數10以上的高級脂肪酸及/或其鹽。就(A)成分的具體例而言,可列舉但未限定於例如:癸酸、月桂酸、肉豆蔻酸、十五酸、棕櫚酸、十七酸、硬脂酸、花生酸、二十二酸等直鏈狀飽和脂肪酸;十一烯酸、棕櫚油酸、油酸、亞麻油酸、次亞麻油酸、牛油酸(vaccenic acid)、反油酸(elaidic acid)、蓖麻油酸、芹子酸、花生油酸、二十碳五烯酸、二十二碳六烯酸等不飽和脂肪酸;異棕櫚酸、異硬脂酸等支鏈狀脂肪酸;椰子油脂肪酸、牛脂脂肪酸、棕櫚仁油脂肪酸等混合脂肪酸;12-羥基硬脂酸、及此等的鹽等。此等能夠單獨使用、或者併用2種以上。
就高級脂肪酸的鹽而言,可列舉但未限定於例如:鉀鹽、鈣鹽、鋰鹽、鈉鹽、鎂鹽等金屬鹽;銨鹽、烷基銨鹽等銨鹽;單乙醇胺鹽、二乙醇胺鹽、三乙醇胺鹽、胺基甲基丙醇鹽、胺基丁三醇鹽等胺鹽等。
上述(A)成分之中,考量顯著地發揮本發明的效果之觀點,較佳為含有選自碳數12~18的高級脂肪酸及該等的鹽構成之群組中之1種以上作為(A)成分。考量更顯著地發揮本發明的效果之觀點,較佳為含有選自月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸及該等的鹽構成之群組中之1種以上作為(A)成分。又,亦較佳為含有選自月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸及該等的鹽構成之群組中之2種以上作為(A)成分,亦較佳為含有選自月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸及該等的鹽構成之群組中之3種以上作為(A)成分。
此外,高級脂肪酸鹽,可以高級脂肪酸鹽的形式摻合於清洗組成物,又,亦可分別獨立摻合高級脂肪酸與鹼,在該組成物中形成高級脂肪酸鹽。
(A)成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,考量顯著地發揮本發明的效果之觀點,相對於清洗組成物總量,例如較佳為10~40質量%,更佳為12~38質量%,進一步更佳為15~36質量%,特佳為20~35質量%。
本發明的實施形態之清洗組成物中,含有選自月桂酸、肉豆蔻酸、棕櫚酸、硬脂酸、及該等的鹽構成之群組中之2種以上作為(A)成分時,該等各成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,例如係如以下。
月桂酸及/或其鹽的含量,相對於清洗組成物總量,例如為1~35質量%、2~15質量%、3~12質量%、4~10質量%等。肉豆蔻酸及/或其鹽的含量,相對於清洗組成物總量,例如為1~35質量%、2~15質量%、3~12質量%、4~10質量%等。棕櫚酸及/或其鹽的含量,相對於清洗組成物總量,例如為1~35質量%、3~30質量%、5~20質量%、8~18質量%等。硬脂酸及/或其鹽的含量,相對於清洗組成物總量,例如為1~35質量%、1.5~30質量%、2~20質量%、3~10質量%等。
〔(B)蛋白質分解酶及/或脂質分解酶〕
本發明的實施形態之清洗組成物所使用之(B)成分,通常只要為外用組成物及/或化妝品所使用之蛋白質分解酶、脂質分解酶,則能夠沒有特別限制地使用。此等能夠單獨使用、或者併用2種以上。
就蛋白質分解酶而言,可為酸性、中性、或鹼性的蛋白質分解酶的任一者,又,可為源自動物、源自植物、或源自微生物的蛋白質分解酶等的任一者。就蛋白質分解酶的具體例而言,可列舉例如:木瓜酶、木瓜凝乳酶(chymopapain)、鳳梨酶(bromelain)、無花果酶(ficin)、胃蛋白酶等源自植物的蛋白質分解酶;胰蛋白酶、胰凝乳蛋白酶(chymotrypsin)、胰酶(pancreatin)等源自動物的蛋白質分解酶;細菌等微生物產生之源自微生物的蛋白質分解酶等。就源自微生物的蛋白質分解酶而言,可列舉例如:桿菌屬(Bacillus)、類芽孢桿菌屬(Paenibacillus)、地芽胞桿菌屬(Geobacillus)、麴菌屬(Aspergillus)、酒麴菌屬(Rhizopus)、根黏菌屬(Rhizomucor)、鏈黴菌屬(Streptomyces)等微生物產生之蛋白質分解酶等。此等能夠單獨使用、或者併用2種以上。
上述蛋白質分解酶之中,考量顯著地發揮本發明的效果之觀點,較佳為源自微生物的蛋白質分解酶、源自植物的蛋白質分解酶,更佳為桿菌屬(Bacillus)的微生物生產之蛋白質分解酶。
就脂質分解酶而言,可為酸性、中性、或鹼性的脂質分解酶的任一者,又,可為源自動物、源自植物、或源自微生物的脂質分解酶等的任一者。就脂質分解酶的具體例而言,可列舉例如:脂酶、磷脂酶、植酸酶等。就源自微生物的脂質分解酶而言,可列舉例如:酒麴菌屬(Rhizopus)、麴菌屬(Aspergillus)、毛黴屬(Mucour)、地絲菌屬(Geotrichum)、念珠菌屬(Candida)、假單胞菌屬(Pseudomonas)、青黴菌屬(Penicillium)、有色桿菌屬(Chromobacterium)等微生物產生之脂質分解酶等。此等能夠單獨使用、或者併用2種以上。此等之中,考量顯著地發揮本發明的效果之觀點,較佳為源自微生物的脂質分解酶。
就(B)成分的市售品而言,可列舉例如:「Bioprase(註冊商標)〔例如:Bioprase XL-416F〕」、「蛋白酶〔例如:Protease CL-15〕」(以上為NagaseChemteX公司製);「Protease N」、「Protease S」、「PAPAIN W-40」(以上為天野製藥公司製);「BIOSOAK」(大和化成公司製);「Alcalase(註冊商標)」、「Esperase(註冊商標)」、「Savinase(註冊商標)」、「Durazyme(註冊商標)」、「Subtilisin A」(以上為諾維賽姆日本公司製);「Lilipase(註冊商標)〔例如:Lilipase A-10D〕」(Nagase ChemteX公司製)等。
(B)成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,考量顯著地發揮本發明的效果之觀點,較佳為摻合量係使得清洗組成物的酶活性成為0.01~5.0U/g之量,更佳為0.1~4.0U/g,進一步更佳為0.5~3.0U/g,特佳為1.0~2.0U/g。
此外,上述單位「U/g」中所謂的「U(單位)」,係表示蛋白質分解酶或脂質分解酶具有之活性,1單位係定義為在最適合條件下(溫度30℃、化學反應最會進行的酸度)每分鐘能夠使1微莫耳(μmol)的基質變化之酶量(每分鐘1微莫耳)。
(B)成分的含量,能夠因應其酶活性(U/g)、其他成分的種類、量、劑型等適當設定,未特別限定,例如為0.01~5質量%、0.05~3質量%、0.08~2質量%、0.1~1質量%等。
(B)成分可為固定化之狀態,即藉由固定化於載體等方法來固定化之酶;或未固定化之狀態,即未藉由固定化於載體等方法來固定化之酶的任一者。就使酶固定化之載體而言,通常可列舉酶的固定化所使用之周知的載體。可列舉例如:各種離子交換樹脂等有機高分子化合物、陶瓷等無機多孔質等。又,就將酶予以固定化之方法而言,能夠採用周知的各種方法。可列舉例如:包埋固定化法、無機載體共價鍵結法、有機載體共價鍵結法、物理吸附法等。本發明即使為酶活性容易降低的未固定化之酶,考量能夠有效地抑制酶活性的降低之點有用性仍特別高。
〔(C)多元醇〕
就本發明的實施形態之清洗組成物所使用之(C)成分而言,通常能夠使用外用組成物及/或化妝品所使用之多元醇。(C)成分的價數(羥基的數量)未特別限制,例如為2~20價,較佳為2~10價,更佳為2~6價,進一步更佳為2~4價。又,(C)成分的分子量,未特別限制,例如為分子量50~1000,較佳為分子量50~600,更佳為分子量75~300。
就(C)成分的具體例而言,可列舉例如:甘油、山梨醇、二甘油、三甘油、丙二醇、二丙二醇、乙二醇、二乙二醇、異戊二醇、丁二醇、丙二醇、木糖醇、赤藻糖醇(erythritol)、甘露醇、戊二醇、己二醇、辛二醇、癸二醇、新戊二醇、聚乙二醇等。
就上述聚乙二醇而言,可列舉例如:平均分子量150~1000的聚乙二醇。具體而言,可列舉:聚乙二醇200(PEG-4)、聚乙二醇300(PEG-6)、聚乙二醇400(PEG-8)、聚乙二醇600(PEG-12)、聚乙二醇1000(PEG-20)等。此外,該平均分子量,例如能夠依據準藥品原料規格2006 聚乙二醇的項目中記載的平均分子量試驗求得。
上述(C)成分,能夠單獨使用、或者併用2種以上,考量發揮本發明的效果之觀點,本發明的實施形態之清洗組成物,必須含有甘油或山梨醇作為(C)成分。
本發明的實施形態之清洗組成物中之(C)成分的含量,考量發揮本發明的效果之觀點,相對於清洗組成物總量,必須為25~60質量%,且甘油及/或山梨醇的含量,相對於清洗組成物總量,必須為10~60質量%。
甘油及/或山梨醇的含量,考量顯著地發揮本發明的效果之觀點,相對於清洗組成物總量,例如較佳為12~55質量%,更佳為15~50質量%,進一步更佳為18~45質量%。
就本發明的實施形態之清洗組成物中之(C)成分而言,考量更進一步提高本發明的效果(尤其是提高水溶性的效果)之觀點,較佳為含有甘油。甘油的含量,考量顯著地發揮本發明的效果(尤其是提高水溶性的效果)之觀點,相對於清洗組成物總量,例如較佳為12~50質量%,更佳為14~45質量%,進一步更佳為16~35質量%。
就本發明的實施形態之清洗組成物中之(C)成分而言,考量更進一步提高本發明的效果(尤其是提高水溶性的效果)之觀點,相對於(C)成分總量之甘油的含量,例如較佳為50質量%以上,更佳為60質量%以上。上限值未特別限制,例如為99.8質量%。
本發明的實施形態之清洗組成物,可為僅含有甘油及/或山梨醇作為(C)成分者,又,亦可為併用甘油及/或山梨醇、以及其他多元醇(即,甘油及山梨醇以外的多元醇)者。就該其他多元醇而言,未特別限制,考量顯著地發揮本發明的效果之觀點,例如較佳為含有選自二甘油、三甘油、丙二醇、二丙二醇、乙二醇、二乙二醇、異戊二醇、丁二醇、及平均分子量為150~1000(更佳為平均分子量為150~600,進一步更佳為150~300)的聚乙二醇構成之群組中之1種以上,更佳為含有選自二甘油、二丙二醇、及丁二醇構成之群組中之1種以上。此等之中,考量更進一步提高本發明的效果(尤其是提高水溶性的效果)之觀點,進一步更佳為併用選自二甘油、二丙二醇、及丁二醇構成之群組中之1種以上與甘油。
本發明的實施形態之清洗組成物中,上述其他多元醇的含量,相對於清洗組成物總量,為0~50質量%。又,上述其他多元醇的含量,能夠在上述範圍內適當設定而未受限定,例如可為5~40質量%、8~30質量%、10~20質量%等。
(A)成分及(C)成分的合計含量〔(A)+(C)〕,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,考量顯著地發揮本發明的效果之觀點,相對於清洗組成物總量,例如較佳為40~90質量%,更佳為45~80質量%,進一步更佳為50~75質量%。
〔(D)水〕
本發明的實施形態之清洗組成物所使用之(D)成分,通常只要為外用組成物及/或化妝品所使用之水,則能夠沒有特別限制地使用。例如較宜使用純水。
(D)成分的含量,考量發揮本發明的效果之觀點,相對於清洗組成物總量,必須為5~30質量%。又,考量更進一步提高本發明的效果(尤其是提高水溶性的效果)之觀點,(D)成分的含量,例如相對於清洗組成物總量,較佳為10~30質量%,更佳為15~30質量%,進一步更佳為20~30質量%。
〔(E)pH調整劑〕
本發明的實施形態之清洗組成物中,除了上述(A)~(D)成分之外,適合使用(E)pH調整劑。就pH調整劑而言,未特別限制,可列舉例如:氫氧化鉀、氫氧化鈉、碳酸鈉等無機鹼;三乙醇胺、二異丙醇胺、三異丙醇胺等有機鹼;鹽酸、硫酸等無機酸;乳酸、乳酸鈉、檸檬酸、檸檬酸鈉、琥珀酸、琥珀酸鈉等有機酸等。此等能夠單獨使用、或者併用2種以上。此等之中,較佳為氫氧化鉀、氫氧化鈉。
(E)成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.1~10質量%、0.3~8質量%、0.5~7質量%等。
〔其他成分〕
本發明的實施形態之清洗組成物,在不損及本發明的效果之範圍,能夠摻合上述(A)~(E)成分以外的成分。本發明的實施形態之清洗組成物,能夠摻合但未限定於例如:基劑、界面活性劑、增黏劑、防腐劑/保存劑、抗氧化劑、螯合劑、著色劑、香料等。此等能夠單獨使用、或者併用2種以上。
就基劑而言,可列舉例如:乙醇、異丙醇等低級醇;液態石蠟、鯊烯、膠化烴(Plastibase等)、地蠟、輕質液態石蠟等烴;甲基聚矽氧烷、交聯型甲基聚矽氧烷、高聚合甲基聚矽氧烷、環狀聚矽氧、烷基改性聚矽氧、交聯型烷基改性聚矽氧、胺基改性聚矽氧、聚醚改性聚矽氧、聚甘油改性聚矽氧、交聯型聚醚改性聚矽氧、交聯型烷基聚醚改性聚矽氧、聚矽氧/烷基鏈共改性聚醚改性聚矽氧、聚矽氧/烷基鏈共改性聚甘油改性聚矽氧、聚醚改性支鏈聚矽氧、聚甘油改性支鏈聚矽氧、丙烯酸聚矽氧、苯基改性聚矽氧、聚矽氧樹脂等聚矽氧油;椰子油、橄欖油、米糠油、乳木果油(shea butter)、玫瑰果油、杏仁油等油脂;荷荷芭油(jojoba oil)、蜂蠟、小燭樹蠟(candelilla wax)、及羊毛脂等蠟類;鯨蠟醇、鯨蠟硬脂醇、硬脂醇、二十二醇、辛基十二醇、異硬脂醇、植物固醇(phytosterol)、及膽固醇等高級醇;二㗁烷;肉豆蔻酸異丙酯、肉豆蔻酸辛基十二酯、棕櫚酸異丙酯、棕櫚酸鯨蠟酯、異壬酸異壬酯、及四-2-乙基己酸新戊四醇等酯類等。此等能夠單獨使用、或者併用2種以上。
基劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為1~30質量%,較佳為3~25質量%,更佳為5~20質量%。
就界面活性劑(但是,高級脂肪酸鹽除外)而言,可列舉例如:非離子性界面活性劑、陰離子性界面活性劑、陽離子性界面活性劑、兩性界面活性劑、源自天然的界面活性劑等。界面活性劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為1~30質量%、5~25質量%、10~20質量%等。
就非離子性界面活性劑而言,可列舉例如:山梨醇酐單異硬脂酸酯、山梨醇酐單月桂酸酯、山梨醇酐單棕櫚酸酯、山梨醇酐單硬脂酸酯、二甘油山梨醇酐五-2-乙基己酯、二甘油山梨醇酐四-2-乙基己酯等山梨醇酐脂肪酸酯類;親油型單硬脂酸甘油酯、自乳化型單硬脂酸甘油酯、單硬脂酸甘油酯蘋果酸等甘油脂肪酸酯類;單硬脂酸聚甘油酯、單異硬脂酸聚甘油酯、二異硬脂酸聚甘油酯、單月桂酸聚甘油酯、單油酸聚甘油酯、單肉豆蔻酸聚甘油酯等聚甘油脂肪酸酯類;單硬脂酸丙二醇等丙二醇脂肪酸酯類;二硬脂酸乙二醇、單硬脂酸乙二醇、二硬脂酸三乙二醇、單硬脂酸聚乙二醇(2E.O.)、單硬脂酸聚乙二醇(4E.O.)、單硬脂酸聚乙二醇(9E.O.)、單硬脂酸聚乙二醇(10E.O.)、單硬脂酸聚乙二醇(23E.O.)、單硬脂酸聚乙二醇(25E.O.)、單硬脂酸聚乙二醇(32E.O.)、單硬脂酸聚乙二醇(40E.O.)、單硬脂酸聚乙二醇(45E.O.)、單硬脂酸聚乙二醇(55E.O.)、單硬脂酸聚乙二醇(75E.O.)、單硬脂酸聚乙二醇(140E.O.)、二硬脂酸聚乙二醇(140E.O.)、二硬脂酸聚乙二醇(250E.O.)等乙二醇脂肪酸酯類;聚氧乙烯硬化蓖麻油40(HCO-40)、聚氧乙烯硬化蓖麻油50(HCO-50)、聚氧乙烯硬化蓖麻油60(HCO-60)、聚氧乙烯硬化蓖麻油80(HCO-80)等硬化蓖麻油衍生物;單月桂酸聚氧乙烯(20)山梨醇酐(聚山梨醇酯20)、單硬脂酸聚氧乙烯(20)山梨醇酐(聚山梨醇60)、單油酸聚氧乙烯(20)山梨醇酐(聚山梨醇酯80)、異硬脂酸聚氧乙烯(20)山梨醇酐等聚氧乙烯山梨醇酐脂肪酸酯類;辛酸N-甲基乙醇醯胺、癸酸N-甲基乙醇醯胺、月桂酸N-甲基乙醇醯胺、月桂酸N-乙基乙醇醯胺、月桂酸N-甲基丙醇醯胺、月桂酸N-乙基丙醇醯胺、月桂酸N-甲基異丙醇醯胺、月桂酸N-乙基異丙醇醯胺、肉豆蔻酸N-甲基乙醇醯胺、棕櫚酸N-甲基乙醇醯胺、椰子油脂肪酸N-甲基乙醇醯胺、椰子油脂肪酸N-乙基乙醇醯胺、椰子油脂肪酸N-甲基丙醇醯胺、椰子油脂肪酸N-乙基丙醇醯胺、椰子油脂肪酸N-甲基異丙醇醯胺、椰子油脂肪酸N-乙基異丙醇醯胺、椰子油脂肪酸二乙醇醯胺、棕櫚仁油脂肪酸N-甲基乙醇醯胺、棕櫚仁油脂肪酸N-乙基乙醇醯胺、硬脂酸N-甲基乙醇醯胺、硬脂酸N-乙基乙醇醯胺、油酸N-甲基乙醇醯胺、油酸N-乙基乙醇醯胺等脂肪酸烷醇醯胺;聚氧乙烯單椰子油脂肪酸甘油酯;甘油烷基醚;己基葡萄糖苷、辛基葡萄糖苷、壬基葡萄糖苷、癸基葡萄糖苷、月桂基葡萄糖苷、肉豆蔻基葡萄糖苷、鯨蠟硬脂基葡萄糖苷、十六基葡萄糖苷、十八基葡萄糖苷、椰子油烷基葡萄糖苷等烷基葡萄糖苷;聚氧乙烯月桂基醚、聚氧乙烯鯨蠟基醚、聚氧乙烯硬脂基醚、聚氧乙烯油基醚、聚氧乙烯二十二基醚等聚氧化烯烷基醚;月桂基PEG-9聚二甲基矽氧基乙基二聚二甲基矽氧烷、PEG-9聚二甲基矽氧基乙基二聚二甲基矽氧烷等聚矽氧系界面活性劑等。
此等之中,較佳為甘油脂肪酸酯類、乙二醇脂肪酸酯類、烷基葡萄糖苷,更佳為自乳化型單硬脂酸甘油酯、二硬脂酸乙二醇、單硬脂酸聚乙二醇(環氧乙烷的平均加成莫耳數為2~400,較佳為10~300,更佳為100~150)、二硬脂酸聚乙二醇(環氧乙烷的平均加成莫耳數為2~400,較佳為100~300)、月桂基葡萄糖苷。
非離子性界面活性劑的HLB值(Hydrophile-Lipophile Balance值),未特別限定,例如為8~19,考量顯著地發揮本發明的效果之觀點,較佳為9~18,更佳為9.5~17。
上述HLB值,係表示親水性-親油性的平衡之指標,係例如以小田/幸村等人之下述(式1)所計算者。
HLB值=(Σ無機性值/Σ有機性值)×10 ...(式1)
Σ無機性值/Σ有機性值係稱為IOB(Inorganic-Organic Balance),能夠依據就各種原子及每個官能基設定之「無機性值」、「有機性值」,藉由累計構成界面活性劑等有機化合物之原子及官能基的「無機性值」、「有機性值」來算出(參照甲田善生著,「有機概念圖-基礎與應用-」,第11~17頁,三共出版,1984年發行)。
非離子性界面活性劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如較佳為1~20質量%、1.5~15質量%、2~12質量%、2.5~10質量%、2.5~8質量%等。
就陰離子性界面活性劑而言,可列舉例如:月桂基硫酸鈉、月桂基硫酸三乙醇胺、月桂醇聚醚硫酸鈉(sodium laureth sulfate)、肉豆蔻基硫酸鈉、硬脂基硫酸鈉、油基硫酸鈉、鯨蠟基硫酸鈉等烷基硫酸酯鹽;聚氧乙烯月桂基醚硫酸鈉、聚氧乙烯肉豆蔻基醚硫酸鈉等聚氧乙烯烷基醚硫酸鹽;肉豆蔻醯基甲基牛磺酸鈉、棕櫚醯基甲基牛磺酸鈉、硬脂醯基甲基牛磺酸鈉、油醯基甲基牛磺酸鈉、椰子油脂肪酸甲基牛磺酸鈉等N-醯基甲基牛磺酸鹽;磺基琥珀酸二辛基鈉、磺基琥珀酸月桂基二鈉等磺基琥珀酸烷基鹽;磺基琥珀酸聚氧乙烯月桂基二鈉等磺基琥珀酸聚氧乙烯烷基鹽;月桂基磷酸鈉、鯨蠟基磷酸鈉、鯨蠟基磷酸二乙醇胺等單烷基磷酸酯鹽;聚氧乙烯月桂基醚磷酸鈉、聚氧乙烯鯨蠟基醚磷酸鈉、聚氧乙烯油基醚磷酸鈉、聚氧乙烯烷基苯基醚磷酸鈉、聚氧乙烯烷基苯基醚磷酸三乙醇胺等聚氧乙烯烷基醚磷酸酯鹽;月桂醯基肌胺酸鉀、月桂醯基肌胺酸三乙醇胺、肉豆蔻醯基肌胺酸鈉、椰子油脂肪酸肌胺酸鈉等N-醯基肌胺酸鹽;月桂醯基甲基丙胺酸鈉、月桂醯基甲基丙胺酸三乙醇胺、肉豆蔻醯基甲基丙胺酸鈉、椰子油脂肪酸甲基丙胺酸鈉等N-醯基-N-甲基-β-丙胺酸鹽;月桂基二醇乙酸鈉(十二烷-1,2-二醇乙酸鈉)、月桂基二醇乙酸鉀、肉豆蔻基二醇乙酸鈉、肉豆蔻基二醇乙酸鉀、棕櫚基二醇乙酸鈉、棕櫚基二醇乙酸鉀、硬脂基二醇乙酸鈉、硬脂基二醇乙酸鉀、二十二基二醇乙酸鈉、二十二基二醇乙酸鉀等烷基醚二醇乙酸鹽等。
就陽離子性界面活性劑而言,可列舉例如:硬脂基三甲基氯化銨、烷基三甲基氯化銨、鯨蠟基三甲基氯化銨、二十二基三甲基氯化銨、二十二基二甲基羥乙基氯化銨、硬脂基二甲基苄基氯化銨、二硬脂基二甲基氯化銨、二鯨蠟基甲基氯化銨、鯨蠟基三乙基甲基硫酸銨、硬脂基三甲基溴化銨、鯨蠟基三甲基溴化銨等。
就兩性界面活性劑而言,可列舉例如:月桂基羥基磺基甜菜鹼、月桂酸醯胺丙基甜菜鹼、2-烷基-N-羧甲基-N-羥乙基咪唑啉鎓甜菜鹼、月桂基二甲基胺基乙酸甜菜鹼、N-月桂醯基-N’-羧甲基-N’-羥乙基乙二胺鈉、月桂醯胺丙基羥基磺基甜菜鹼、月桂酸醯胺丙基二甲基胺氧化物、羥烷基(C12-14)羥乙基肌胺酸、椰子油脂肪酸醯胺丙基甜菜鹼等。
就源自天然的界面活性劑而言,可列舉例如:卵磷脂、氫化卵磷脂、皂素、表面活性素鈉、膽酸等。
就增黏劑而言,可列舉例如:膠類(結蘭膠、黃原膠、菌核膠、刺槐豆膠、生物糖膠、羅望子膠、木梨籽、阿拉伯膠、塔拉膠、瓜爾膠、半乳聚糖、阿拉伯膠、黃蓍膠等)、卡拉膠、卡德蘭膠、琥珀聚醣、類肝素物質、海藻酸類(海藻酸、海藻酸鈉、海藻酸丙二醇等)、洋菜(包含洋菜糖)、明膠、果膠、聚三葡萄糖、甘露聚糖、乙烯基系增黏劑(聚乙烯醇、聚乙烯吡咯啶酮、聚乙烯甲基醚、羧乙烯聚合物等)、纖維素系增黏劑(甲基纖維素、乙基纖維素、羥乙基纖維素、羥甲基纖維素、羥丙基纖維素、羥丙基甲基纖維素、羧甲基纖維素、羧乙基纖維素、疏水化羥丙基甲基纖維素等)、聚葡萄糖、糊精、丙烯酸甲基丙烯酸烷酯共聚物、聚丙烯酸鈉、膨土、糊精脂肪酸酯、二甲基二硬脂基銨鋰膨潤石、聚乙二醇、聚乙烯二醇(macrogol)、(丙烯酸羥乙酯/丙烯醯基二甲基牛磺酸鈉)共聚物、(丙烯醯基二甲基牛磺酸銨/乙烯基吡咯啶酮)共聚物等。
增黏劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.01~3質量%,更佳為0.05~1質量%。
就防腐劑/保存劑而言,可列舉例如:異丙基甲基酚、氯丁醇、苄醇、苯乙醇、苯甲酸、苯甲酸鈉、脫水乙酸、脫水乙酸鈉、對羥基苯甲酸異丁酯、對羥基苯甲酸異丙酯、對羥基苯甲酸丁酯、對羥基苯甲酸乙酯、對羥基苯甲酸丙酯、對羥基苯甲酸苄酯、對羥基苯甲酸甲酯(methyl paraben)、苯氧基乙醇、乙基己基甘油、癸酸甘油酯、戊二醇、己二醇、氯苯甘醚(chlorphenesin)等。
防腐劑/保存劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~2.5質量%,較佳為0.005~2質量%,更佳為0.01~1質量%。
就抗氧化劑而言,可列舉例如:二丁基羥基甲苯(BHT)、丁基羥基大茴香醚、山梨酸、焦亞硫酸鈉、異抗壞血酸(erythorbic acid)、L-半胱胺酸鹽酸鹽等。抗氧化劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~2.5質量%,較佳為0.005~2質量%,更佳為0.01~1質量%。
就螯合劑而言,可列舉例如:EDTA/二鈉鹽、EDTA/鈣/二鈉鹽等。
螯合劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~2.5質量%,較佳為0.005~2質量%,更佳為0.01~1質量%。
就著色劑而言,可列舉例如:無機顏料、天然色素等。
著色劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~1質量%,較佳為0.005~0.1質量%,更佳為0.01~0.05質量%。
就香料而言,可列舉例如:薄荷腦、樟腦、冰片、香葉醇、桉樹腦、大茴香腦、檸檬烯、丁香酚等類萜類。
香料的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物整體,例如為0.001~2.5質量%,較佳為0.005~2質量%,更佳為0.01~1質量%。
本發明的實施形態之清洗組成物,在不損及本發明的效果之範圍,能夠含有其他有效成分。就有效成分的具體例而言,可列舉但未限定於例如:保濕成分、去角質劑、血液循環促進劑、收斂成分、紫外線吸收成分、抗菌成分、消炎劑、維生素類、肽或其衍生物、胺基酸或其衍生物、細胞活化成分等。此等能夠單獨使用、或者併用2種以上。
就保濕成分而言,可列舉例如:乳酸鈉、脲、吡咯啶酮甲酸鈉等天然保濕因子;洋甘菊萃取物、金縷梅萃取物、茶萃取物、紫蘇萃取物、薏苡仁(鳩麥)萃取物、雷公根葉萃取物、海藻萃取物、枇杷葉萃取物、紫草萃取物、越橘葉萃取物、珊瑚草萃取液、白柳樹皮萃取物、迷迭香萃取物、大豆萃取物、豆芽萃取物、陳皮萃取物、柑橘萃取物、葡萄柚萃取物、檸檬萃取物、虎耳草萃取物、雪絨花萃取物等植物萃取物等。
保濕成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~20質量%,較佳為0.01~15質量%,更佳為0.05~10質量%。
就去角質劑而言,可列舉例如:杏核粉末、杏仁殼粉末、氯化鈉顆粒、橄欖核粉末、海水乾燥物顆粒、小燭樹蠟、核桃殼粉末、櫻桃核粉末、珊瑚粉末、碳粉末(泡桐碳、備長碳、竹碳、柏木碳、椰子殼碳及此等的活性碳、以及此等的藥用碳)、榛殼粉末、聚乙烯粉末、矽酸酐、高嶺土等。
去角質劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.01~15質量%,較佳為0.05~10質量%,更佳為0.1~5質量%。
就血液循環促進劑而言,可列舉例如:乙醯膽鹼、魚石脂、咖啡因、辣椒素、斑螫酊、γ-穀醇、薑酊、薑酮、千金藤素、當藥萃取物、單寧酸、辣椒酊、托拉唑啉(tolazoline)、菸鹼酸生育酚、菸鹼酸苄酯等。
血液循環促進劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.005~3質量%,更佳為0.01~1質量%。
就收斂成分而言,可列舉例如:硫酸鋅、羥基鋁、氯化鋁、磺基石碳酸鋅及單寧酸等。
收斂成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~20質量%,較佳為0.01~15質量%,更佳為0.1~10質量%。
就紫外線吸收成分而言,可列舉例如:辛基三𠯤酮、二乙基胺基羥基苄醯基苯甲酸己酯、二甲氧基亞苄基二側氧基咪唑啶丙酸辛酯、對甲氧基桂皮酸2-乙基己酯、三級丁基甲氧基二苄醯基甲烷、苯基苯并咪唑磺酸、甲氧基桂皮酸辛酯、甲氧基桂皮酸乙基己酯等。
紫外線吸收成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為1~30質量%,較佳為3~25質量%,更佳為5~20質量%。
就抗菌成分而言,可列舉例如:異丙基甲基酚、氯己定(chlorhexidine)、殺藻胺(benzalkonium chloride)、雷佛奴爾(acrinol)、氯化苯索寧(benzethonium chloride)、甲酚、葡萄糖酸及其衍生物、優碘、碘化鉀、碘、三氯卡班(triclocarban)、三氯沙(triclosan)、感光素101號、感光素201號、對羥基苯甲酸酯、苯氧基乙醇、鹽酸烷基二胺基甘胺酸、吡羅克酮乙醇胺(piroctone olamine)、咪可納唑(miconazole)等。
抗菌成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~2.5質量%,較佳為0.005~2質量%,更佳為0.01~1質量%。
就消炎劑而言,可列舉例如:非類固醇系消炎劑、或類固醇系消炎劑等。具體而言,可列舉:甘草酸、甘草次酸、甘草次酸硬脂酯、尿囊素、ε-胺基己酸、水楊酸、水楊酸甲酯、水楊酸二醇、吲哚美辛(indometacin)、聯苯乙酸(felbinac)、布洛芬(ibuprofen)、布洛芬匹康醇(ibuprofen piconol)、酮洛芬(ketoprofen)、丁苯羥酸(bufexamac)、氟苯胺酸丁酯(butyl flufenamate)、苄達(bendazac)、匹洛西卡(piroxicam)、舒洛芬(suprofen)、薁、癒創木烯(guaiazulene)、乙酸地塞米松戊酸酯(dexamethasone acetate valerate)、地塞米松(dexamethasone)、乙酸普賴蘇穠戊酸酯(普賴蘇穠戊酸酯乙酸酯,Prodnisolone Acetate Valerate)、普賴蘇穠乙酸酯(prednisolone acetate)、普賴蘇穠(prednisolone)、乙酸皮質醇(hydrocortisone acetate)、皮質醇(hydrocortisone)、吾非那美(ufenamate)、丁苯羥酸(bufexamac)、及此等的鹽等。
消炎劑的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.005~4.5質量%,更佳為0.01~3質量%。
就維生素類而言,可列舉例如:dl-α-生育酚、d-δ-生育酚、琥珀酸dl-α-生育酚、琥珀酸dl-α-生育酚鈣等維生素E類;核黃素、黃素單核苷酸、黃素腺嘌呤二核苷酸、核黃素丁酸酯、核黃素四丁酸酯、核黃素5’-磷酸酯鈉、核黃素四菸鹼酸酯等維生素B2類;dl-α-生育酚菸鹼酸酯、菸鹼酸苄酯、菸鹼酸甲酯、菸鹼酸β-丁氧基乙酯、菸鹼酸1-(4-甲基苯基)乙酯等菸鹼酸類;抗壞血酸-A、L-抗壞血酸2-葡萄糖苷、抗壞血酸硬脂酸酯、抗壞血酸棕櫚酸酯、L-抗壞血酸二棕櫚酸酯等維生素C類;甲基橙皮苷、麥角鈣化醇(ergocalciferol)、膽鈣化醇(cholecalciferol)等維生素D類;葉醌(phylloquinone)、金合歡醌(farnoquinone)等維生素K類;γ-穀醇、二苄醯基硫胺素、二苄醯基硫胺素鹽酸鹽、硫胺素鹽酸鹽、硫胺素鯨蠟基鹽酸鹽、硫胺素硫氰酸鹽、硫胺素月桂基鹽酸鹽、硫胺素硝酸鹽、硫胺素單磷酸鹽、硫胺素離胺酸鹽、硫胺素三磷酸鹽、硫胺素單磷酸酯磷酸鹽、硫胺素單磷酸酯、硫胺素二磷酸酯、硫胺素二磷酸酯鹽酸鹽、硫胺素三磷酸酯、硫胺素三磷酸酯單磷酸鹽等維生素B1類;鹽酸吡哆醇、乙酸吡哆醇、鹽酸吡哆醛、5’-磷酸吡哆醛、鹽酸吡哆胺等維生素B6類;氰鈷胺素、羥鈷胺、脫氧腺苷鈷胺等維生素B12類;葉酸、喋醯基麩胺酸等葉酸類;菸鹼酸、菸鹼酸醯胺等菸鹼酸類;泛酸、泛酸鈣、泛酸基醇(泛醇)、D-泛酸、D-泛雙硫醇、輔酶A、泛酸基乙基醚等泛酸類;生物素、生物胞素(biocytin)等生物素類;抗壞血酸、抗壞血酸鈉、脫氫抗壞血酸、抗壞血酸磷酸酯鈉、抗壞血酸磷酸酯鎂等抗壞血酸衍生物之維生素C類;視黃醇、氫化視黃醇、棕櫚酸視黃醇等維生素A類;肉鹼、阿魏酸、α-硫辛酸、乳清酸等類維生素因子等。
維生素類的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~25質量%,較佳為0.01~20質量%,更佳為0.05~15質量%。
就肽或其衍生物而言,可列舉例如:角蛋白分解肽、水解角蛋白、膠原蛋白、源自魚的膠原蛋白、去端膠原蛋白(atelocollagen)、明膠、彈性蛋白、彈性蛋白分解肽、膠原蛋白分解肽、水解膠原蛋白、羥丙基氯化銨水解膠原蛋白、彈性蛋白分解肽、貝殼素分解肽、水解貝殼素、絲蛋白分解肽、水解絲、月桂醯基水解絲鈉、大豆蛋白水解肽、水解大豆蛋白、小麥蛋白、小麥蛋白分解肽、水解小麥蛋白、酪蛋白分解肽、醯化肽(棕櫚醯基寡肽、棕櫚醯基五肽、棕櫚醯基四肽等)等。
肽或其衍生物的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.01~3質量%,更佳為0.05~1質量%。
就胺基酸或其衍生物而言,可列舉例如:甜菜鹼(三甲基甘胺酸)、脯胺酸、羥基脯胺酸、精胺酸、離胺酸、絲胺酸、甘胺酸、丙胺酸、苯基丙胺酸、β-丙胺酸、蘇胺酸、麩胺酸、麩醯胺酸、天冬醯胺酸、天冬胺酸、半胱胺酸、胱胺酸、甲硫胺酸、白胺酸、異白胺酸、纈胺酸、組胺酸、牛磺酸、γ-胺基丁酸、γ-胺基-β-羥基丁酸、肉鹼、肌肽、肌酸等。
胺基酸或其衍生物的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.01~3質量%,更佳為0.05~1質量%。
就細胞活化成分而言,可列舉例如:乙醇酸、乳酸等α-羥基酸類;單寧;類黃酮、皂素、感光素301號等。
細胞活化成分的含量,能夠因應其他成分的種類、量、劑型等適當設定,未特別限定,相對於清洗組成物總量,例如為0.001~5質量%,較佳為0.01~3質量%,更佳為0.05~1質量%。
[清洗組成物的pH]
本發明的實施形態之清洗組成物的pH,能夠因應劑型等適當設定,未特別限定,例如較佳為pH8.0~12.0。又,本發明的實施形態之清洗組成物的pH,考量抑制酶活性的降低之觀點,更佳為pH9.0~11.5,進一步更佳為pH9.0~11.0。
此外,上述pH係使用pH計(例如:pH METER F-52(堀場公司製))在室溫(23℃)測定。
[黏度]
本發明的實施形態之清洗組成物的黏度(25℃),能夠因應劑型等適當設定,未特別限定,考量填充於管型的容器時容易吐出,或不會從指尖、手掌滴落而容易起泡之觀點,較佳為30,000~2,000,000mPa.s,更佳為60,000~1,800,000mPa.s,進一步較佳為100,000~1,500,000mPa.s,進一步更佳為150,000~1,300,000mPa.s,最佳為150,000~1,000,000mPa.s。
上述黏度(25℃),係指依據日本藥典第17版的一般試驗法中記載的黏度測定法,利用單一圓筒形旋轉黏度計(布氏黏度計)測定之黏度。具體而言,係指使用TV-10M(東機產業公司製)測定之值,轉子、旋轉速度等條件的選定,係依據本機的操作說明書,測定25℃之黏度。更具體而言,係使用M4轉子,在旋轉速度0.3rpm、測定時間180秒鐘的條件下,測定25℃之黏度。
以下記載關於單一圓筒形旋轉黏度計之說明。單一圓筒形旋轉黏度計,係測定以一定角速度使液體中的圓筒旋轉時的轉矩之黏度計。事先藉由使用黏度計校正用標準液實驗性地確定裝置常數KB,利用下式算出液體的黏度η。
η=KB×T/ω
η:液體的黏度(mPa.s)
KB:裝置常數(rad/cm
3)
ω:角速度(rad/s)
T:作用於圓筒面之轉矩(10
-7N.m)
<本發明的有用性>
蛋白質分解酶、脂質分解酶,若在水的存在下保存一定時間則酶活性會降低或失去活性,因此為了在清洗組成物中維持酶活性,通常必須極度減少清洗組成物所含之水的含量。若極度減少清洗組成物所含之水的含量,則有清洗組成物與水的親和性會降低,在使用時水溶性變差之傾向,或有清洗組成物本身變得過硬而填充於管型的容器時的吐出性降低之傾向等使用性惡化的情況。從而,一邊維持蛋白質分解酶、脂質分解酶的酶活性,一邊提供使用性優異的清洗組成物是極為困難的。
本發明的實施形態之清洗組成物,藉由解決上述困難的課題,能夠抑制蛋白質分解酶、脂質分解酶的酶活性的降低,穩定地保持酶活性,且考量能夠提供使用性優異的清洗組成物之點是有用的。
具體而言,本發明的實施形態之清洗組成物,與蛋白質分解酶、脂質分解酶一起摻合高級脂肪酸及/或其鹽、特定的多元醇、以及水,並將該多元醇與水的含量控制在特定範圍,藉此能夠抑制蛋白質分解酶、脂質分解酶的酶活性的降低,穩定地持續酶活性,因此能夠藉由分解角質、皮脂而有效地清洗皮膚等。即,本發明的實施形態之清洗組成物,例如即使在製造後經過規定時間後,仍能夠維持蛋白質分解酶、脂質分解酶的酶活性,因此在使用時,成為角質去除效果、皮脂去除效果等清洗效果優異者。
而且,本發明的實施形態之清洗組成物,例如使用時的水溶性良好,因此成為使用性優異者。
考量更進一步提高本發明的有用性之觀點,就本發明的較佳實施形態而言,可列舉例如:使清洗組成物的pH成為(B)成分的最適合pH附近。藉此,成為角質去除效果、皮脂去除效果等清洗效果更進一步優異者。
此外,上述所謂(B)成分的最適合pH附近,係意指清洗組成物的pH為(B)成分的最適合pH的±2.0,較佳為±1.5,進一步更佳為±1.0。又,所謂(B)成分的最適合pH,係意指顯示最大酶活性之pH,能夠藉由周知的方法來測定。能夠但未限定於例如:對於5mL的0.6質量%牛奶酪蛋白,加入1mL的(B)成分〔例如:Bioprase (註冊商標)XL-416F(NagaseChemteX公司製)〕,使用pH調整劑將pH調整至4.0~12.0之間,使其在30℃反應10分鐘時,將酶的相對活性成為最高之pH定為最適合pH。
又,考量更進一步提高本發明的有用性之觀點,就本發明的較佳實施形態而言,可列舉例如:含有鹼性蛋白質分解酶(鹼性蛋白酶)及/或鹼性脂質分解酶(鹼性脂酶)作為(B)成分,使清洗組成物的pH成為9.0以上。藉此,成為角質去除效果、皮脂去除效果等清洗效果更進一步優異者。此外,所謂鹼性蛋白質分解酶(鹼性蛋白酶),係意指最適合pH位於鹼性區域之蛋白質分解酶,例如:最適合pH為9.0以上的蛋白質分解酶。又,所謂鹼性脂質分解酶(鹼性脂酶),係意指最適合pH位於鹼性區域之脂質分解酶,例如:最適合pH為9.0以上的脂質分解酶。就本發明的更佳實施形態而言,可列舉:使用最適合pH為9.0~11.0的鹼性蛋白質分解酶及/或鹼性脂質分解酶,將清洗組成物的pH設定為9.0~11.0。
本發明的實施形態之清洗組成物中,抑制蛋白質分解酶、脂質分解酶的酶活性的降低之效果,例如:能夠藉由比較清洗組成物的剛製備時測定之酶活性、與在規定時間保存後測定之酶活性來評價。就具體的一例而言,能夠藉由後述實施例中記載的方法來評價。就本發明的實施形態之清洗組成物而言,較佳為根據後述實施例中記載的方法或以此為基準之方法求得之酶活性殘留率為70%以上,更佳為80%以上,進一步更佳為90%以上。
[製劑型態]
本發明的實施形態之清洗組成物,係摻合上述各成分,並因應需要摻合進一步的成分,依照常法,製備成各種形態。製劑型態未特別限定,可為沐浴皂、洗手皂、潔顏劑、洗髮精等任意的劑型。再者,可為清潔劑、二合一洗髮精、潤髮乳等形態。又,本發明的實施形態之清洗組成物,可為凝膠狀、糊狀等任意的形狀。
[用途]
本發明的實施形態之清洗組成物,適合作為皮膚用清洗組成物、毛髮用清洗組成物使用。其中,本發明的實施形態之清洗組成物,用於去除皮膚(包含頭皮)的油脂、汗等體液、髒污等是有用的,其中,能夠特別適合作為臉用清洗組成物(潔顏劑)使用。就本發明的實施形態之清洗組成物的使用方法而言,例如:將清洗組成物與水混合並以手掌起泡而塗布於皮膚等來使用。
[容器]
本發明的實施形態之清洗組成物,能夠因應使用目的及用途,填充於適當選擇之容器來使用。就該容器而言,可列舉例如:瓶型、管型、罐型、分配器型、小袋、及吸嘴袋等。又,就構成容器之材料而言,可列舉例如:聚對苯二甲酸乙二酯、聚丙烯、聚乙烯(HDPE、LDPE、LLDPE等)、ABS樹脂、乙烯-乙烯醇樹脂、聚苯乙烯、玻璃、及金屬(鋁等)、及此等的混合物。又,由此等材料成形之容器,考慮到強度、柔軟性、耐候性、或成分的穩定性等,例如能夠對容器表面施予各種塗布處理。又,亦能夠將由上述材料成形之薄膜等予以積層以成形容器。
此等各種容器之中,較佳為藉由使用者以手握住容器並施加壓力而可將容器的內容物(清洗組成物)擠出來使用的容器,例如較佳為管型的容器、瓶型的容器。其中,考量顯著地發揮本發明的效果之觀點,特佳為管型的容器。就管型的容器而言,能夠使用周知的管型的容器(例如,參照但未特別限定於日本特開2000-272643號公報、日本特開2004-148628號公報、日本特開2005-022682號公報等)。就管型的容器的具體的一例而言,可列舉例如:具有容納清洗組成物之本體、與蓋子之容器。該本體具有:將聚乙烯等合成樹脂製的單層或積層薄片(薄片的總厚度例如為約0.1~1mm左右)予以捲繞,使兩端部重合並熱封而形成圓筒狀之身體部、將該身體部的一端予以熱封成扁平狀所形成之底部密封部、與設於該身體部的另一端之頭部。該頭部具有肩部、與設於該肩部的大約中央之排出口部,該排出口部係開關自由地被蓋子被覆。使用者可藉由以手握住該身體部並施加壓力而將容器的內容物(清洗組成物)擠出來使用,因此考量能夠提供使用性優異的清洗組成物之點是極為有用的。又,填充於管型的容器之清洗組成物,係阻隔性和衛生面亦優異,且重量輕、攜帶性亦優異,因此考量此等的點亦是極為有用的。
<酶活性的降低的抑制方法>
就本發明的其他實施形態而言,亦適合提供作為抑制酶活性的降低之方法。例如,適合提供作為含有以下步驟之抑制酶活性的降低之方法:在藉由混合(A)高級脂肪酸及/或其鹽、(B)蛋白質分解酶及/或脂質分解酶、(C)多元醇、以及(D)水來抑制酶活性的降低之方法中,相對於清洗組成物總量,將上述(C)多元醇的含量調配成25~60質量%,同時相對於清洗組成物總量,將作為上述(C)的甘油及/或山梨醇的含量調配成10~60質量%之步驟;與相對於清洗組成物總量,將(D)水的含量調配成5~30質量%之步驟。
<製造方法>
本發明的實施形態之清洗組成物之製造方法,未特別限制,能夠依常法來製造。例如,能夠加入(A)~(D)、因應需要的其他成分,將此等予以混合藉此來製造。
就本發明的實施形態之清洗組成物的適合製造方法而言,可列舉例如:至少具有將含有(C)與(D)之相I、及含有(A)之相II予以混合、攪拌,並冷卻之步驟之製造方法。具體而言,例如適合為具有在含有加熱至60℃以上之(C)與(D)之相I中,添加含有在60~80℃加熱溶解之(A)之相II並攪拌後,經過冷卻步驟,在55℃以下添加(B)之步驟之製造方法。
更具體而言,首先,將(C)及(D)加熱至60℃以上來製備相I。該加熱溫度能夠在60℃以上的範圍中適當設定,例如較佳為60~85℃,更佳為70~80℃。此外,相I中可含有(C)及(D)以外的成分。
接著,將(A)予以加熱熔融來製備相II。該加熱溫度能夠在60~80℃的範圍中適當設定,例如較佳為70~80℃。此外,相II中可含有(A)以外的成分。
對於上述所得之相I添加相II並攪拌,將所得之混合物予以冷卻後,添加(B)。具體而言,例如:一邊攪拌相I,一邊慢慢地添加相II並攪拌,所得之混合物冷卻至55℃以下後,一邊攪拌混合物一邊添加(B)。前述冷卻後的溫度,能夠在55℃以下的範圍中適當設定,考量顯著地發揮本發明的效果之觀點,較佳為30~55℃,更佳為32~45℃。添加(B)後將混合物予以攪拌直到均勻,可得到本發明的實施形態之清洗組成物。
〔實施例〕
以下,進一步詳細地說明本發明,但本發明未限定於此等。此外,顯示實施例等之表1、表2及製劑例的含量的單位為質量%,為全部換算為純成分之值。又,各組成物的合計量為100質量%。
藉由常法製備下述表1、表2所示之配方的清洗組成物(實施例1~9、比較例1~5),如下述般評價酶活性及使用性。
[表1]
(質量%)
※1 Bioprase(註冊商標) XL-416F(Nagase ChemteX公司製,純成分含量20%。表中所示之含量為純成分之蛋白質分解酶的含量。)
※2 Plantacare(註冊商標) 1200UP(BASF公司製,純成分含量52%。表中所示之含量為純成分之月桂基葡萄糖苷的含量。)
※3 RHEODOL(註冊商標) MS-165V(花王公司製)
實施例1 | 實施例2 | 實施例3 | 實施例4 | 實施例5 | 比較例1 | 比較例2 | 比較例3 | 比較例4 | 比較例5 | ||
A成分 | 月桂酸 | 5 | 5 | 5 | 7 | 5 | 5 | 5 | 5 | 5 | 5 |
肉豆蔻酸 | 9 | 9 | 9 | 7 | 9 | 9 | 9 | 9 | 9 | 9 | |
棕櫚酸 | 10 | 10 | 10 | 14 | 10 | 10 | 10 | 10 | 10 | 10 | |
硬脂酸 | 4 | 4 | 4 | - | 4 | 4 | 4 | 4 | 4 | 4 | |
B成分 | 蛋白質分解酶 ※1 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 | 0.12 |
C成分 | 甘油 | 40.3 | 40.3 | 30.3 | 20.3 | 0.3 | 0.3 | 5.3 | 20.3 | 20.3 | 10.3 |
山梨醇 | - | - | - | - | 30 | - | - | - | - | - | |
丁二醇 | - | 17.3 | 5 | 4 | 5 | 40 | 35 | 10 | 5 | 5 | |
二甘油 | - | - | 5 | 4 | 5 | - | - | - | - | - | |
二丙二醇 | - | - | - | 4 | - | - | - | - | - | - | |
丙二醇 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | 0.18 | |
D成分 | 純水 | 22.5 | 5.2 | 22.5 | 29.1 | 22.5 | 22.5 | 22.5 | 32.5 | 37.5 | 47.5 |
E成分 | 氫氧化鉀 | 5.4 | 5.4 | 5.4 | 6.5 | 5.4 | 5.4 | 5.4 | 5.4 | 5.4 | 5.4 |
氫氧化鈉 | - | - | - | 0.3 | - | - | - | - | - | - | |
月桂基葡萄糖苷 ※2 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | 2.5 | |
自乳化型單硬脂酸甘油酯 ※3 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
合計量 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | 100 | |
pH(23℃) | 9.5 | 9.5 | 9.2 | 9.6 | 9.1 | 9.3 | 9.3 | 9.0 | 9.1 | 9.1 | |
評價 | 酶活性殘留率 | ◎ | ◎ | ◎ | ◎ | ◎ | × | × | × | × | × |
水溶性 | ○ | ○ | ◎ | ◎ | △ | - | - | - | - | - |
[表2]
(質量%)
※1 Bioprase XL-416F
(NagaseChemteX公司製,純成分含量20%。表中所示之含量為純成分之蛋白質分解酶的含量。)
※2 Plantacare 1200UP
(BASF公司製,純成分含量52%。表中所示之含量為純成分之月桂基葡萄糖苷的含量。)
※3 RHEODOL MS-165V(花王公司製)
實施例6 | 實施例7 | 實施例8 | 實施例9 | ||
A成分 | 月桂酸 | 5 | 5 | 5 | 5 |
肉豆蔻酸 | 9 | 9 | 9 | 9 | |
棕櫚酸 | 10 | 10 | 10 | 10 | |
硬脂酸 | 4 | 4 | 4 | 4 | |
B成分 | 蛋白質分解酶 ※1 | 0.12 | 0.12 | 0.12 | 0.12 |
C成分 | 甘油 | 40.3 | 40.3 | 40.3 | 40.3 |
丙二醇 | 0.18 | 0.18 | 0.18 | 0.18 | |
D成分 | 純水 | 24.9 | 23.9 | 21.6 | 20.9 |
E成分 | 氫氧化鉀 | 3 | 4 | 6.3 | 7 |
月桂基葡萄糖苷 ※2 | 2.5 | 2.5 | 2.5 | 2.5 | |
自乳化型硬脂酸甘油酯 ※3 | 1 | 1 | 1 | 1 | |
合計量 | 100 | 100 | 100 | 100 | |
pH(23℃) | 7.0 | 8.9 | 10.0 | 12.0 | |
評價 | 酶活性殘留率 | ◎ | ◎ | ◎ | △ |
水溶性 | △ | ◎ | ◎ | ◎ |
<酶活性評價試驗>
使用Pierce Protease Assay Kit(賽默飛世爾科技公司製),依照規定的程序,利用以下方法來評價在40℃保存1個月後之酶活性。
首先,分別準備定量用緩衝液(50mM硼酸鹽,pH8.5)、將10mg的冷凍乾燥琥珀醯化酪蛋白溶解於5mL的上述定量用緩衝液而得之琥珀醯化酪蛋白溶液、及將100μL的TNBSA(三硝基苯磺酸)原液加至14.9mL的上述定量用緩衝液而得之TNBSA稀釋標準溶液(TNBSA Working Solution)。
接著,對於100μL的上述定量用緩衝液加入50μL的實施例1的清洗組成物並混合,在25℃的條件下靜置20分鐘後,進一步加入50μL的TNBSA稀釋標準溶液並混合,再次在25℃靜置20分鐘,製備對照用樣品。使用吸光度測定器(SH-9000Lab,科羅娜電氣公司製)測定控制用樣品剛製備時450nm的吸光度(A
CT)。
又,對於100μL的上述琥珀醯化酪蛋白溶液加入50μL的實施例1的清洗組成物並混合,在25℃的條件下靜置20分鐘後,進一步加入50μL的TNBSA稀釋標準溶液並混合,再次在25℃靜置20分鐘,製備測定用樣品。使用吸光度測定器(SH-9000Lab,科羅娜電氣公司製)分別測定測定用樣品剛製備時450nm的吸光度(A1)、及在40℃保存1個月後在450nm的吸光度(A2)。
依據下述式求出實施例1的酶活性殘留率,依據以下基準進行評價。將其結果示於表1。
[式] 酶活性殘留率(%)=[A2-A
CT]/[A1-A
CT]×100
(評價基準)
◎(優異)....酶活性殘留率為90%以上
○(良好) ....酶活性殘留率為70%以上且未達90%
△(好) ....酶活性殘留率為50%以上且未達70%
×(差) ....酶活性殘留率未達50%
利用與上述相同的方法來評價實施例2~9、比較例1~5的酶活性殘留率。將其結果示於表1、表2。
<使用性評價試驗(水溶性)>
在20mL的燒杯中裝入1g的實施例1的清洗組成物後,投入10g的水(23℃)。放入四氟乙烯樹脂製轉子(直徑5mm,全長15mm,亞速旺公司製),使用磁攪拌器(HE-16GX6,小池精密機器製作所公司製)在300rpm條件下進行攪拌,依據下述評價基準進行水溶性的評價。將其結果示於表1。
此外,下述評價基準中所謂的溶解時間,係意指從開始上述攪拌到以目視觀察清洗組成物的結塊消失為止的時間。
(評價基準)
◎(優異)....溶解時間未達5分鐘
○(良好) ....溶解時間為5分鐘以上且未達10分鐘
△(好) ....溶解時間為10分鐘以上
利用與上述相同的方法評價實施例2~9的水溶性。將其結果示於表1、表2。此外,在表中以「-」表示未評價水溶性者。
如表1、表2所示,確認了本發明的實施例1~9,即使在40℃保存1個月後,酶活性殘留率仍高,仍維持酶活性。
另一方面,確認了甘油及/或山梨醇的含量少的比較例1及2、水的含量多的比較例3及4、以及多元醇的含量少且水的含量多的比較例5,在40℃保存1個月後,酶活性殘留率顯著降低,未保持酶活性。
如表1、表2所示,確認了本發明的實施例1~9係水溶性優異。
依據以上,確認了如本發明,根據含有(A)高級脂肪酸及/或其鹽、(B)蛋白質分解酶及/或脂質分解酶、(C)多元醇、以及(D)水,相對於清洗組成物總量(C)的含量為25~60質量%,相對於清洗組成物總量(D)的含量為5~30質量%,含有甘油及/或山梨醇作為上述(C),相對於清洗組成物總量甘油及/或山梨醇的含量為10~60質量%之清洗組成物,能夠抑制(B)蛋白質分解酶、脂質分解酶的酶活性的降低。又,確認了本發明的清洗組成物係水溶性優異。
此外,實施例1~9的組成物之蛋白質分解酶的酶活性(U/g)皆為1.5(U/g)。該酶活性(U/g)係在5mL的0.6質量%牛奶酪蛋白(pH7.5,M/25磷酸緩衝液)中加入1mL的(B)蛋白質分解酶〔Bioprase (註冊商標)XL-416F(NagaseChemteX公司製)〕,使其在30℃反應10分鐘時,將每1分鐘相當於1μg的酪胺酸之弗林顯色作為TCA(三氯乙酸)可溶性成分游離之活性當作1單位所測定之值。
以下顯示本發明的製劑例。
此外,所有的製劑例皆保持酶活性,顯示良好的酶活性。
<潔顏劑1(填充於管型的容器之潔顏劑)>
水 30質量%
甘油 17質量%
1,3-丁二醇 8.85質量%
蛋白質分解酶 0.1質量%
脂質分解酶 0.1質量%
糊精 1.9質量%
丙二醇 0.15質量%
月桂酸 5質量%
肉豆蔻酸 10質量%
棕櫚酸 13質量%
硬脂酸 5質量%
高嶺土 1質量%
氫氧化鉀 6質量%
抗壞血酸 1質量%
羥丙基甲基纖維素 0.5質量%
香料 0.3質量%
聚四級銨鹽-7 0.1質量%
合計量 100質量%
pH(23℃) 9.2
水溶性 ◎
※蛋白質分解酶:Bioprase (註冊商標)XL-416F(NagaseChemteX公司製)
※脂質分解酶:Lilipase(註冊商標)A-10D(NagaseChemteX公司製)
<潔顏劑2(填充於管型的容器之潔顏劑)>
水 15質量%
甘油 30質量%
PEG-8 12.955質量%
丙二醇 0.075質量%
蛋白質分解酶 0.05質量%
脂質分解酶 0.05質量%
糊精 0.95質量%
月桂酸 5質量%
肉豆蔻酸 9質量%
棕櫚酸 10質量%
硬脂酸 4質量%
焦亞硫酸鈉 0.02質量%
氫氧化鉀 5質量%
月桂基葡萄糖苷 6質量%
羥丙基甲基纖維素 0.5質量%
香料 0.3質量%
自乳化型單硬脂酸甘油酯 1質量%
聚四級銨鹽-10 0.1質量%
合計量 100質量%
pH(23℃) 9.2
水溶性 ◎
※蛋白質分解酶:Bioprase (註冊商標)XL-416F(NagaseChemteX公司製)
※脂質分解酶:Lilipase(註冊商標)A-10D(NagaseChemteX公司製)
<潔顏劑3(填充於管型的容器之潔顏劑)>
月桂酸 5質量%
肉豆蔻酸 9質量%
棕櫚酸 10質量%
硬脂酸 4質量%
蛋白質分解酶 0.12質量%
甘油 39質量%
丙二醇 0.18質量%
純水 24.4質量%
氫氧化鉀 3.5質量%
月桂基葡萄糖苷 2.5質量%
自乳化型硬脂酸甘油酯 1質量%
絲胺酸 0.1質量%
1,3-丙二醇 1質量%
枇杷葉萃取物 0.1質量%
越橘葉萃取物 0.1質量%
合計量 100質量%
pH(23℃) 8.0
水溶性 ○
※蛋白質分解酶:Bioprase XL-416F(NagaseChemteX公司製)
<潔顏劑4(填充於管型的容器之潔顏劑)>
月桂酸 5質量%
肉豆蔻酸 9質量%
棕櫚酸 10質量%
硬脂酸 4質量%
蛋白質分解酶 0.12質量%
甘油 39.4質量%
丙二醇 0.18質量%
純水 21.2質量%
氫氧化鉀 6.7質量%
月桂基葡萄糖苷 2.5質量%
自乳化型硬脂酸甘油酯 1質量%
三甲基甘胺酸 0.1質量%
海藻糖 0.5質量%
紫草葉萃取物 0.1質量%
茶葉萃取物 0.1質量%
葡萄柚萃取物 0.1質量%
合計量 100質量%
pH(23℃) 11.0
水溶性 ◎
※蛋白質分解酶:Bioprase XL-416F(NagaseChemteX公司製)
<潔顏劑5(填充於管型的容器之潔顏劑)>
月桂酸 8質量%
肉豆蔻酸 8質量%
棕櫚酸 12質量%
油酸 1.5質量%
蛋白質分解酶 0.12質量%
甘油 33.5質量%
丙二醇 0.18質量%
純水 25質量%
氫氧化鉀 6.5質量%
氫氧化鈉 0.3質量%
月桂基葡萄糖苷 2.5質量%
自乳化型硬脂酸甘油酯 1質量%
絲胺酸 0.5質量%
海藻糖 0.5質量%
枇杷葉萃取物 0.1質量%
檸檬萃取物 0.1質量%
茶葉萃取物 0.2質量%
合計量 100質量%
pH(23℃) 9.5
水溶性 ◎
※蛋白質分解酶:Bioprase XL-416F(NagaseChemteX公司製)
<潔顏劑6(填充於管型的容器之潔顏劑)>
月桂酸 8質量%
肉豆蔻酸 8質量%
棕櫚酸 12質量%
異硬脂酸 1.5質量%
蛋白質分解酶 0.12質量%
甘油 34.289質量%
丙二醇 0.18質量%
純水 25質量%
氫氧化鉀 6.5質量%
氫氧化鈉 0.3質量%
月桂基葡萄糖苷 2.5質量%
自乳化型硬脂酸甘油酯 1質量%
三甲基甘胺酸 0.5質量%
海藻萃取物 0.01質量%
枇杷葉萃取物 0.001質量%
葡萄柚萃取物 0.1質量%
合計量 100質量%
pH(23℃) 9.5
水溶性 ◎
※蛋白質分解酶:Bioprase XL-416F(NagaseChemteX公司製)
<液體沐浴乳>
水 25質量%
甘油 35質量%
乙醇 18.75質量%
蛋白質分解酶 0.1質量%
丙二醇 0.15質量%
月桂酸 7質量%
肉豆蔻酸 5質量%
棕櫚酸 2質量%
氫氧化鉀 4質量%
椰子油脂肪酸二乙醇醯胺 1質量%
羥丙基甲基纖維素 0.6質量%
香料 0.3質量%
碳 1質量%
聚四級銨鹽-10 0.1質量%
合計量 100質量%
pH(23℃) 10.0
水溶性 ◎
※蛋白質分解酶:Bioprase (註冊商標)XL-416F(NagaseChemteX公司製)
上述實施例、製劑例中,顯示本發明之具體的形態,但上述實施例、製劑例僅為例示,並非限定性地解釋者。對於發明所屬技術領域中具有通常知識者來說顯而易見的各種變形,被劃在本發明的範圍內。
〔產業上的可利用性〕
本發明的清洗組成物,適合作為皮膚用清洗組成物、毛髮用清洗組成物使用。其中,能夠特別適合作為臉用清洗組成物(潔顏劑)使用。
Claims (10)
- 一種清洗組成物,其含有: (A)高級脂肪酸及/或其鹽; (B)蛋白質分解酶及/或脂質分解酶; (C)多元醇;以及 (D)水; 該(C)的含量,相對於清洗組成物總量,為25~60質量%; 該(D)的含量,相對於清洗組成物總量,為5~30質量%; 含有甘油及/或山梨醇作為該(C); 該甘油及/或山梨醇的含量,相對於清洗組成物總量,為10~60質量%。
- 如請求項1之清洗組成物,其中該(A)為碳數12~18的高級脂肪酸及/或其鹽。
- 如請求項1或2之清洗組成物,其中該(B)為未固定化之狀態的蛋白質分解酶及/或脂質分解酶。
- 如請求項1或2之清洗組成物,其中該(B)為鹼性蛋白質分解酶及/或鹼性脂質分解酶。
- 如請求項1或2之清洗組成物,其含有甘油作為該(C)。
- 如請求項1或2之清洗組成物,其中該(D)的含量,相對於清洗組成物總量,為15~30質量%。
- 如請求項1或2之清洗組成物,其進一步含有(E)pH調整劑。
- 如請求項1或2之清洗組成物,其中清洗組成物的pH為8.0~12.0。
- 如請求項1或2之清洗組成物,其係填充於管型的容器。
- 一種如請求項1之清洗組成物之製造方法,其具有以下步驟: 在含有加熱至60℃以上之該(C)與(D)之相I中,添加含有在60~80℃加熱溶解之(A)之相II並攪拌後,經過冷卻步驟,在55℃以下添加(B)。
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JP3380156B2 (ja) * | 1998-03-02 | 2003-02-24 | 株式会社資生堂 | 酵素配合組成物 |
JP2004307360A (ja) * | 2003-04-02 | 2004-11-04 | Kose Corp | 洗浄料組成物 |
JP4397269B2 (ja) * | 2004-04-26 | 2010-01-13 | 関西酵素株式会社 | 蛋白分解酵素安定化剤、化粧料及び洗浄剤 |
JP5210693B2 (ja) | 2008-04-11 | 2013-06-12 | 持田製薬株式会社 | 酵素配合洗顔パウダー |
JP2013006789A (ja) * | 2011-06-24 | 2013-01-10 | Nicostar Beautech Kk | 安定なタンパク質分解酵素含有液状化粧料 |
JP2013221012A (ja) * | 2012-04-17 | 2013-10-28 | Nicostar Beautech Kk | 安定なタンパク質分解酵素含有液状化粧料 |
JP6125896B2 (ja) * | 2013-05-14 | 2017-05-10 | 富士フイルム株式会社 | 皮膚洗浄料 |
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