TW202317574A - Cdk2抑制劑 - Google Patents

Cdk2抑制劑 Download PDF

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Publication number
TW202317574A
TW202317574A TW111123974A TW111123974A TW202317574A TW 202317574 A TW202317574 A TW 202317574A TW 111123974 A TW111123974 A TW 111123974A TW 111123974 A TW111123974 A TW 111123974A TW 202317574 A TW202317574 A TW 202317574A
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TW
Taiwan
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group
alkyl
cancer
independently selected
halo
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TW111123974A
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English (en)
Chinese (zh)
Inventor
道格拉斯 威爾遜
尼爾 二世 比富爾科
娜塔莎 布魯傑孟
約瑟夫 金
艾曼紐 裴洛拉
菲利浦 D 雷姆斯頓
里查德 瓦格斯
史蒂文 馬克 溫洛斯基
Original Assignee
美商纜圖藥品公司
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Publication of TW202317574A publication Critical patent/TW202317574A/zh

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50Pyridazines; Hydrogenated pyridazines
    • A61K31/501Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D519/00Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05Isotopically modified compounds, e.g. labelled

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
TW111123974A 2021-06-28 2022-06-27 Cdk2抑制劑 TW202317574A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163215901P 2021-06-28 2021-06-28
US63/215,901 2021-06-28

Publications (1)

Publication Number Publication Date
TW202317574A true TW202317574A (zh) 2023-05-01

Family

ID=82655170

Family Applications (1)

Application Number Title Priority Date Filing Date
TW111123974A TW202317574A (zh) 2021-06-28 2022-06-27 Cdk2抑制劑

Country Status (19)

Country Link
US (3) US11932648B2 (enExample)
EP (1) EP4363423A1 (enExample)
JP (1) JP2024524373A (enExample)
KR (1) KR20240046167A (enExample)
CN (1) CN117897384A (enExample)
AR (1) AR126251A1 (enExample)
AU (1) AU2022301047A1 (enExample)
CA (1) CA3223223A1 (enExample)
CL (1) CL2023003965A1 (enExample)
CO (1) CO2024000237A2 (enExample)
CR (1) CR20230598A (enExample)
DO (1) DOP2023000280A (enExample)
EC (1) ECSP24006831A (enExample)
IL (1) IL309118A (enExample)
MX (1) MX2024000230A (enExample)
PE (1) PE20250123A1 (enExample)
TW (1) TW202317574A (enExample)
UY (1) UY39832A (enExample)
WO (1) WO2023278326A1 (enExample)

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JP2026501701A (ja) * 2023-01-04 2026-01-16 ブループリント メディシンズ コーポレイション Cdk2阻害剤の固体形態
CN120813586A (zh) * 2023-01-04 2025-10-17 缆图药品公司 Cdk2抑制剂
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UY40638A (es) 2023-02-17 2024-08-30 Novartis Ag Inhibidores de quinasa dependientes de ciclina (cdk2)
WO2025188779A1 (en) 2024-03-04 2025-09-12 Blueprint Medicines Corporation Cdk2 inhibitors for treatment of cancer
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WO2026038120A1 (en) * 2024-08-12 2026-02-19 Novartis Ag Synthesis and crystalline forms of a cdk2 inhibitor
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EP4646416A1 (en) 2023-01-04 2025-11-12 Blueprint Medicines Corporation Cdk2 inhibitors
CN120813586A (zh) 2023-01-04 2025-10-17 缆图药品公司 Cdk2抑制剂
CN121311229A (zh) 2023-02-10 2026-01-09 缆图药品公司 用于治疗癌症的cdk2抑制剂blu-222
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Also Published As

Publication number Publication date
AU2022301047A1 (en) 2024-01-04
CL2023003965A1 (es) 2024-12-06
US20240383902A1 (en) 2024-11-21
CN117897384A (zh) 2024-04-16
WO2023278326A1 (en) 2023-01-05
DOP2023000280A (es) 2024-03-28
AR126251A1 (es) 2023-10-04
US11970498B2 (en) 2024-04-30
US20230159535A1 (en) 2023-05-25
EP4363423A1 (en) 2024-05-08
CA3223223A1 (en) 2023-01-05
US11932648B2 (en) 2024-03-19
KR20240046167A (ko) 2024-04-08
US20230322791A1 (en) 2023-10-12
PE20250123A1 (es) 2025-01-16
ECSP24006831A (es) 2024-07-31
MX2024000230A (es) 2024-04-01
UY39832A (es) 2023-01-31
US12545684B2 (en) 2026-02-10
IL309118A (en) 2024-02-01
CO2024000237A2 (es) 2024-02-05
CR20230598A (es) 2024-04-25
JP2024524373A (ja) 2024-07-05

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