TW202315883A - 適用於口服的glp-1及gip受體共促效劑 - Google Patents

適用於口服的glp-1及gip受體共促效劑 Download PDF

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Publication number
TW202315883A
TW202315883A TW111150185A TW111150185A TW202315883A TW 202315883 A TW202315883 A TW 202315883A TW 111150185 A TW111150185 A TW 111150185A TW 111150185 A TW111150185 A TW 111150185A TW 202315883 A TW202315883 A TW 202315883A
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compound
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amino
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TW111150185A
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Chinese (zh)
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派屈克 J 克內爾
布萊恩 菲南
理查 帝馬奇
拉斯 林德羅史
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丹麥商諾佛 儂迪克股份有限公司
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Publication of TW202315883A publication Critical patent/TW202315883A/zh

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/542Carboxylic acids, e.g. a fatty acid or an amino acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/605Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
TW111150185A 2020-07-22 2021-07-22 適用於口服的glp-1及gip受體共促效劑 TW202315883A (zh)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US202063055026P 2020-07-22 2020-07-22
US63/055,026 2020-07-22
EP20192414 2020-08-24
EP20192414.9 2020-08-24
US202163156988P 2021-03-05 2021-03-05
US63/156,988 2021-03-05

Publications (1)

Publication Number Publication Date
TW202315883A true TW202315883A (zh) 2023-04-16

Family

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Family Applications (2)

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TW110126883A TWI801942B (zh) 2020-07-22 2021-07-22 適用於口服的glp-1及gip受體共促效劑
TW111150185A TW202315883A (zh) 2020-07-22 2021-07-22 適用於口服的glp-1及gip受體共促效劑

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US (4) US20230272029A1 (enExample)
EP (1) EP4185607A1 (enExample)
JP (2) JP7581385B2 (enExample)
KR (2) KR20230029480A (enExample)
CN (1) CN116157143A (enExample)
AU (1) AU2021312323A1 (enExample)
BR (1) BR112023000270A2 (enExample)
CA (1) CA3184717A1 (enExample)
CL (1) CL2023000087A1 (enExample)
CO (1) CO2023000097A2 (enExample)
IL (1) IL299701A (enExample)
MX (1) MX2023000303A (enExample)
PE (1) PE20231841A1 (enExample)
TW (2) TWI801942B (enExample)
WO (1) WO2022018186A1 (enExample)

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WO2025114501A1 (en) 2023-11-30 2025-06-05 Novo Nordisk A/S Tri-agonists of the glp-1, gip, and amylin receptors
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Also Published As

Publication number Publication date
KR102446310B1 (ko) 2022-09-23
JP2023534131A (ja) 2023-08-08
US20230120597A1 (en) 2023-04-20
KR20220012840A (ko) 2022-02-04
US20220125940A1 (en) 2022-04-28
CN116157143A (zh) 2023-05-23
WO2022018186A1 (en) 2022-01-27
JP2025020197A (ja) 2025-02-12
PE20231841A1 (es) 2023-11-21
MX2023000303A (es) 2023-02-09
BR112023000270A2 (pt) 2023-01-31
CA3184717A1 (en) 2022-01-27
KR20230029480A (ko) 2023-03-03
US20220177538A1 (en) 2022-06-09
US20230272029A1 (en) 2023-08-31
TWI801942B (zh) 2023-05-11
JP7581385B2 (ja) 2024-11-12
IL299701A (en) 2023-03-01
EP4185607A1 (en) 2023-05-31
AU2021312323A1 (en) 2023-02-02
TW202208411A (zh) 2022-03-01
CL2023000087A1 (es) 2023-07-07
CO2023000097A2 (es) 2023-03-27
US11779648B2 (en) 2023-10-10

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