TW202248218A - 細胞介素結合物 - Google Patents
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Abstract
本發明係關於包含與延伸重組多肽(XTEN)連接之生物活性蛋白質(諸如細胞介素)的組合物,編碼該等組合物之分離核酸及含有該等核酸之載體及宿主細胞,及使用此類組合物治療相關病症及病況之方法。
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序列表之電腦可讀形式隨此申請案以電子方式提交申請且以全文引用之方式併入本申請案中。序列表包含在2021年6月14日創建之文件中,其文件名為「776-601_20-1836-WO_ST25_FINAL.txt」且大小為988 kb。
參考敍述
本申請案主張於2020年6月25日提交之美國臨時專利申請案第63/044,335號,標題為「CYTOKINE CONJUGATES」;於2021年6月7日提交之美國臨時專利申請案第63/197,875號,標題為「CYTOKINE CONJUGATES」;及於2021年6月7日提交之美國臨時專利申請案第63/197,944號,標題為「CYTOKINE CONJUGATES」之優先權,以上所有申請案之全部內容以引用之方式併入本文中。
細胞介素可用於治療多種疾病或病況,諸如癌症、發炎性病況、自體免疫性病況、類風濕性關節炎、多發性硬化、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症(Alzheimer's disease)、精神分裂症、病毒感染(例如,慢性C型肝炎、AIDS)、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症。然而,細胞介素之治療效用可能由於細胞毒性、短半衰期、需要重複或頻繁給藥及引起患者之非所需免疫反應的潛在性而受到限制。
臨床環境中之大部分細胞介素產品極其有效。諸如IL-2及IL-12及IFN-a之介白素為細胞介素,其主要由免疫系統細胞產生以信號傳導及組織免疫反應。在癌症中,細胞介素促進免疫系統將腫瘤細胞識別為異常及對宿主有害之能力。細胞介素進一步增加TME增殖,增強其存活且引導多種免疫細胞類型來浸潤TME且促進有效抗腫瘤免疫反應,導致腫瘤細胞殺死及腫瘤清除。此限制細胞介素在治療環境中,尤其在抗癌適應症中之實際應用。
尤其介白素-12(IL12)已公認為具有作為用於腫瘤免疫療法之理想有效負載之潛能。其可活化免疫系統之先天性及適應性組分。IL12刺激IFN-γ之產生且活化NK細胞以及CD8+及CD4+ T細胞。另外,此細胞介素亦誘導抗血管生成趨化介素、腫瘤細胞外基質之重塑及MHC I類分子表現之刺激,使其成為極具吸引力之抗癌候選物。然而,雖然研究人員已展示令人鼓舞的臨床前資料,但此細胞介素之嚴重毒性概況已阻止了劑量遞增,且顯著抑制了作為抗癌劑之臨床潛力。儘管自1996年首次進行人類IL12臨床試驗以來,多個臨床試驗一直在進行,但FDA批准之IL12產品仍然遙遙無期。
此對可克服治療指數挑戰以使用細胞介素作為抗癌劑的新策略提出了相當大的未滿足需求。若如IL12之細胞介素之效力可被安全地利用且可控制毒性挑戰,則此等藥劑可充當針對廣泛範圍之癌症之潛在用途的強大治療劑。
本揭示案包括可解決一或多個缺點或可提供一或多個優點之細胞介素相關組合物及相關方法。在一個態樣中,本文揭示一種融合蛋白,其包含:
(a) 延伸重組多肽(extended recombinant polypeptide,XTEN),其特徵在於:
i. 其包含至少12個胺基酸;
ii. XTEN序列之至少90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%的胺基酸殘基係選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P);及
iii. 其具有4至6個選自G、A、S、T、E及P之不同胺基酸;及
(b) 與該XTEN連接之細胞介素。
在一些實施例中,融合蛋白進一步包含釋放區段,其中該釋放區段(RS)與選自
表 6 至表 7中所闡述之序列的序列具有至少88%、至少94%或100%序列一致性。在一些實施例中,融合蛋白具有XTEN-RS-細胞介素或細胞介素-RS-XTEN之自N端至C端的結構排列。
在一些實施例中,細胞介素係選自由介白素、趨化介素、干擾素、腫瘤壞死因子、群落刺激因子或TGF-β超家族成員組成之群。在一些實施例中,細胞介素係選自由以下組成之群的介白素:IL1、IL2、IL3、IL4、IL5、IL6、IL7、IL8、IL9、IL10、IL11、IL12、IL13、IL14、IL15、IL16及IL17。在一些實施例中,細胞介素與選自
表 3或
表 A之序列具有至少90%序列一致性。在一些實施例中,細胞介素為IL-12或IL-12變異體。在一些實施例中,細胞介素包含第一細胞介素片段(Cy1)及第二細胞介素片段(Cy2)。在一些實施例中,Cy1及Cy2中之一者包含與介白素-12次單元β具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的胺基酸序列。在一些實施例中,Cy1及Cy2中之另一者包含與介白素-12次單元α具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的胺基酸序列。在一些實施例中,第一細胞介素片段(Cy1)包含與序列
SEQ ID NO. 5具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列。在一些實施例中,第二細胞介素片段(Cy2)包含與序列
SEQ ID NO. 6具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列。在一些實施例中,細胞介素包含位於第一細胞介素片段(Cy1)及第二細胞介素片段(Cy2)之間的連接子。在一些實施例中,細胞介素為包含與
SEQ ID NO. 7具有至少90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列的IL-12變異體。
在一些實施例中,XTEN序列由多個非重疊序列模體組成,其中該等序列模體選自
表 2 a 至表 2 b之序列模體。在一些實施例中,XTEN具有40至3000個胺基酸,或100至3000個胺基酸。在一些實施例中,XTEN與
表 2 a 至表 2 b中所闡述之序列具有至少90%、至少91%、至少92%、至少93%、至少94%、至少95%、至少96%、至少97%、至少98%或至少99%或100%序列一致性。
在一些實施例中,其中當連接至融合蛋白中之XTEN時,細胞介素與相應細胞介素受體之結合活性的特徵在於半最大有效濃度(EC50)比當未與XTEN連接時在活體外結合分析中測定之表徵細胞介素的相應結合活性的EC50大至少1.2倍、大至少1.4倍、大至少1.6倍、大至少1.8倍、大至少2.0倍、大至少3.0倍、大至少4.0倍、大至少5.0倍、大至少6.0倍、大至少7.0倍、大至少8.0倍、大至少9.0倍或大至少10.0倍。在一些實施例中,細胞介素可為介白素12(IL-12)且相應細胞介素受體可為介白素12受體(IL-12R)。在一些實施例中,活體外結合分析可利用基因工程改造之報導基因細胞株,該細胞株經組態成以報導蛋白的成比例表現對該細胞介素與該相應細胞介素受體之結合作出反應。在一些實施例中,活體外結合分析可為報導基因活性分析。
在另一態樣中,本揭示案提供一種組合物,其包含本文所揭示之融合蛋白及至少一種醫藥學上可接受之載劑。
在另一態樣中,本揭示案提供一種本發明組合物之用途,其用於製備用於治療有需要之個體之疾病的藥劑。
在一相關態樣中,本揭示案提供一種治療或預防個體之疾病或病況的方法,該方法包含向個體投與治療有效量之融合蛋白或包含該融合蛋白之組合物,以上所有均揭示於本文中。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況或發炎性或自體免疫性疾病。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況。可用本發明融合物及組合物治療之疾病或病況包括(但不限於)癌症、類風濕性關節炎、多發性硬化症、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症、精神分裂症、病毒感染、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況。必要時,本發明融合物及組合物可與治療有效量之至少一種免疫檢查點抑制劑結合使用。必要時,投與模式可為經靜脈內、皮下或經口遞送。
以引用之方式進行之併入
本說明書中所提及之所有公開案、專利及專利申請案均以引用之方式併入本文中,其引用的程度如同各個別公開案、專利或專利申請案經特定及個別地指示以引用的方式併入一般。
雖然細胞介素仍可能為強力治療劑,但即使在低濃度下,此等藥劑亦產生限制其在臨床環境中之實際應用的副作用。本揭示案利用細胞介素學相關組合物及相關方法之治療潛力,同時控制彼等強力化合物之有害影響。更特定言之,本揭示案係關於稱為
Xten化
蛋白酶
活化細胞
介素(XPAC)之特定BPXTEN分子,其在存在於腫瘤微環境中之蛋白酶存在下條件性活化。本申請案係關於用於製備XPAC之方法及組合物。雖然本揭示案提供具有IL12之某些實例,但應理解,本揭示案廣泛適用於任何細胞介素,其活性應較佳減弱直至其在作用部位處提供之時為止。XPAC提供一種可由IL12在T細胞及NK細胞介導之發炎反應中之作用而產生的有效克服腫瘤誘導之免疫抑制的方法。
如上文所指出,細胞介素為強效免疫促效劑,然而,此強力類別化合物之相對狹窄治療窗限制了其在治療環境中的應用前景。其具有短半衰期,極其強效,且產生顯著不合需要的全身性效應及毒性。另外,藉由需要投與大量細胞介素進一步窄化治療窗,以便在腫瘤或腫瘤微環境中在細胞介素作用之預期部位處達成細胞介素之所需水準。因此,細胞介素迄今為止未能在臨床環境中達到其用於治療腫瘤的潛力。
本發明妨礙細胞介素在腫瘤學中之臨床用途的克服毒性及短半衰期缺點。本發明之XPAC含有具有受體促效劑活性之細胞介素多肽。但在XPAC之上下文中,細胞介素受體促效劑活性減弱且循環半衰期延長。XPAC包括蛋白酶裂解位點,其藉由與細胞介素活性之所需位點(例如腫瘤)相關之蛋白酶裂解,且通常富集或選擇性存在於所需活性位點處。因此,XPAC優先(或選擇性地)且在所要作用部位處有效地裂解。此將細胞介素活性實質上限制至所需活性位點,諸如腫瘤微環境。在所需活性位點,諸如在腫瘤微環境中之蛋白酶裂解自XPAC釋放細胞介素形式,其作為細胞介素受體促效劑的活性比連接有XTEN分子的XPAC高得多。自XPAC裂解XTEN後釋放之細胞介素形式典型地具有短半衰期,其通常實質上類似於天然存在之細胞介素的半衰期。此有利地限制細胞介素對腫瘤微環境之活性。儘管XPAC之半衰期延長,但毒性顯著降低或消除,因為循環XPAC減弱且活性細胞介素靶向腫瘤微環境。本文所描述之XPAC首次能夠投與有效治療劑量之細胞介素來治療具有基本上限於腫瘤微環境之細胞介素活性的腫瘤,且顯著減少或消除細胞介素之非所需全身效應及毒性。
在描述本發明之實施例之前,應理解,此類實施例僅藉助於實例提供,且本文所描述之本發明之實施例的各種替代方案可用於實踐本發明。熟習此項技術者可在不背離本發明之情況下想到許多變化形式、改變及取代。
除非另有定義,否則本文中所使用之所有技術及科學術語具有與一般熟習本發明所屬之技術者通常所理解相同之意義。儘管類似或等效於本文所描述之彼等方法及材料可用於實踐或測試本發明,但合適的方法及材料描述如下。在衝突之情況下,將以專利說明書(包括定義)為準。另外,材料、方法及實例僅為說明性的,且不意欲為限制性的。熟習此項技術者可在不背離本發明之情況下想到許多變化形式、改變及取代。
定義
如本文所使用,除非另外規定,否則以下術語具有歸屬於其之意義。
除非上下文另外明確指示,否則如本說明書及申請專利範圍中所用,單數形式「一(a/an)」及「該」包括複數個參考物。舉例而言,術語「一個細胞」包括複數個細胞,包括其混合物。
術語「細胞介素」為熟習此項技術者所熟知,且係指由尤其免疫系統之細胞分泌且為免疫調節劑之一類免疫調節蛋白中之任一者。可用於本文中所揭示之XPAC中的細胞介素多肽包括但不限於:介白素,諸如IL-1、IL-1.α.、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9、IL-10、IL-11、IL-12、IL-13、IL-14、IL-15、IL-16、IL-17、IL-18、IL-21及IL-25;轉型生長因子,諸如TGF-.α.及TGF-.β.(例如TGFβ1、TGFβ2、TGFβ3);干擾素,諸如干擾素-.α.、干擾素-.β.、干擾素-.γ.、干擾素-κ及干擾素-ω;腫瘤壞死因子,諸如腫瘤壞死因子α及淋巴毒素;趨化介素(例如C--X--C模體趨化介素10(CXCL10)、CCL19、CCL20、CCL21);及顆粒球群落刺激因子(GM-CS);以及其保留受體促效劑活性的功能片段。「趨化介素」為此項技術中之術語,其係指具有在鄰近反應性細胞中誘導定向趨化性之能力的一個小細胞介素家族中之任一者。
如本文所用,術語「可活化」、「活化」、「誘導」及「可誘導」係指作為XPAC之一部分的蛋白質(亦即細胞介素)結合其受體且在XTEN自XPAC裂解後實現活性的能力。
熟習此項技術者應理解術語「半衰期延長」用以意謂與作為XPAC之一部分的細胞介素相比,XPAC藉由例如改變其大小(例如高於腎臟過濾截止值)、形狀、流體動力學半徑、電荷或吸收、生物分佈、代謝及消除之參數來增加血清半衰期且改善pK。
術語「多肽」、「肽」及「蛋白質」在本文中可互換使用,係指任何長度之胺基酸之聚合物。聚合物可為直鏈或分支鏈,其可包含經修飾之胺基酸,且其可間雜有非胺基酸。術語亦涵蓋已經修飾之胺基酸聚合物,例如藉由二硫鍵形成、醣基化、脂質化、乙醯化、磷酸化或任何其他操縱,諸如與標記組分結合。
如本文所用,術語「胺基酸」係指天然及/或非天然或合成胺基酸,包括但不限於甘胺酸及D或L光學異構物兩者,及胺基酸類似物及肽類比物。標準單字母或三字母編碼用於指示胺基酸。
術語「天然L-胺基酸」意謂甘胺酸(G)、脯胺酸(P)、丙胺酸(A)、纈胺酸(V)、白胺酸(L)、異白胺酸(I)、甲硫胺酸(M)、半胱胺酸(C)、苯丙胺酸(F)、酪胺酸(Y)、色胺酸(W)、組胺酸(H)、離胺酸(K)、精胺酸(R)、麩醯胺酸(Q)、天冬醯胺(N)、麩胺酸(E)、天冬胺酸(D)、絲胺酸(S)及蘇胺酸(T)之L光學異構物形式。
應用於序列且如本文所用之術語「非天然存在之」意謂不具有針對哺乳動物中發現之野生型或天然存在之序列之對應物、不與其互補或不與其具有較高程度之同源性的多肽或聚核苷酸序列。舉例而言,當適當地比對時,非天然存在之多肽可相比於天然序列共有不超過99%、98%、95%、90%、80%、70%、60%、50%或甚至更少胺基酸序列一致性。
術語「親水性」及「疏水性」係指物質與水具有之親和力的程度。親水性物質對於水具有強親和力,傾向於溶解於水中、與水混合或藉由水潤濕,而疏水性物質對於水基本上不具有親和力,傾向於排斥水且不吸收水且傾向於不溶解於水中或與水混合或藉由水潤濕。胺基酸可基於其疏水性來表徵。已開發出多種標度。實例為由Levitt, M等人, J Mol Biol (1976) 104:59開發之標度,其列舉於Hopp, TP等人, Proc Natl Acad Sci U S A (1981) 78:3824中。「親水性胺基酸」之實例係精胺酸、離胺酸、蘇胺酸、丙胺酸、天冬醯胺以及麩醯胺酸。備受關注的為親水性胺基酸天冬胺酸、麩胺酸及絲胺酸及甘胺酸。「疏水性胺基酸」之實例為色胺酸、酪胺酸、苯丙胺酸、甲硫胺酸、白胺酸、異白胺酸及纈胺酸。
「片段」係天然生物活性蛋白之截斷形式,其保留治療活性及/或生物活性之至少一部分。「變異體」為與天然生物活性蛋白具有序列同源性的蛋白質,其保留生物活性蛋白之至少一部分治療活性及/或生物活性。舉例而言,變異體蛋白可與參考生物活性蛋白共有至少70%、75%、80%、85%、90%、95%、96%、97%、98%或99%胺基酸序列一致性。如本文所用,術語「生物活性蛋白部分」包括經過故意修飾之蛋白質,如例如藉由定點誘變、插入或偶然經由突變來進行修飾。
「宿主細胞」包括可為或已為本發明載體之受體的單獨細胞或細胞培養物。宿主細胞包括單一宿主細胞之後代。由於自然、偶然或目的性突變,後代可能未必與原始母細胞完全相同(在形態或總DNA互補序列之基因體方面)。宿主細胞包括經本發明之載體活體內轉染之細胞。
當用於描述本文所揭示之不同多肽時,「經分離」意謂已識別及分離及/或自其天然環境之組分回收的多肽。其天然環境之污染組分為將通常干擾多肽之診斷或治療用途之材料,且可包括酶、激素及其他蛋白質或非蛋白質溶質。如熟習此項技術者所顯而易知,非天然存在之聚核苷酸、肽、多肽、蛋白質、抗體或其片段不需要「分離」以將其與其天然存在之對應體區分開。另外,「濃縮」、「分離」或「稀釋」之聚核苷酸、肽、多肽、蛋白質、抗體或其片段可與其天然存在之對應體區分開,因為每體積之濃度或分子數一般大於其天然存在之對應體的濃度或分子數。一般而言,將藉由重組方式製得且表現於宿主細胞中之多肽視為「經分離」。
「經分離」聚核苷酸或多肽編碼核酸或其他多肽編碼核酸為經鑑別且與在多肽編碼核酸之天然來源中通常與其相關聯之至少一種雜質核酸分子分離的核酸分子。經分離之多肽編碼核酸分子不呈其於自然界中所發現之形式或設定。經分離之多肽編碼核酸分子因此與其存在於天然細胞中時之特定多肽編碼核酸分子區分開。然而,經分離之多肽編碼核酸分子包括細胞中所含之多肽編碼核酸分子,該等細胞通常在例如核酸分子所處之染色體或染色體外位置不同於天然細胞之情況下表現多肽。
「嵌合」蛋白質含有至少一種融合多肽,其在與天然存在不同之序列位置包含至少一個區。區可通常存在於獨立蛋白質中且在融合多肽中結合在一起;或其可通常存在於相同蛋白質中,但在融合多肽中以新排列形式置放。嵌合蛋白可例如藉由化學合成,或藉由產生及轉譯肽區以所需關係編碼之聚核苷酸而產生。
在本文中,「結合(Conjugated)」、「連接(linked)」、「融合(fused)」及「融合(fusion)」可互換地使用。此等術語係指藉由包括化學結合或重組手段之任何手段使多於兩種化學元素或組分接合在一起。舉例而言,若啟動子或強化子影響序列之轉錄,則啟動子或強化子可操作地連接於編碼序列。一般而言,「可操作地連接」意謂連接之DNA序列為連續的,且在閱讀相內或框內。「框內融合」係指兩個或更多個開放閱讀框架(ORF)以維持原始ORF之適當閱讀框架的方式接合以形成連續較長ORF。因此,所得重組融合蛋白為單一蛋白質,其含有兩個或更多個對應於由原始ORF編碼之多肽的區段(該等區段在自然界中通常不如此接合)。術語「連接(link/linked/linking)」以最廣泛意義使用,且特定言之意欲以直接或間接方式包括治療劑之部分與治療劑之另一部分的共價及非共價連接。如本文在治療劑之上下文中所用之術語「直接連接」一般係指其中部分與另一部分連接或附接而無介入繫鏈之結構。如本文在治療劑之上下文中所用之術語「間接連結」一般係指其中治療劑之部分經由介入繫鏈與治療劑之另一部分連接或附接之結構。
在多肽之上下文中,「線性序列」或「序列」為呈至羧基末端方向之多肽中之胺基酸次序,其中序列中彼此相鄰之殘基在多肽之一級結構中為連續的。「部分序列」為已知沿一個或兩個方向包含額外殘基之多肽之一部分的線性序列。
「異源」意謂衍生自與其所比較的實體的其餘部分在基因型上不同的實體。舉例而言,自其天然編碼序列移除且以可操作地連接至除天然序列以外之編碼序列的甘胺酸富集序列為異源甘胺酸富集序列。應用於聚核苷酸、多肽之術語「異源」意謂聚核苷酸或多肽衍生自與其所比較之實體之其餘部分在基因型上不同的實體。
術語「聚核苷酸」、「核酸」、「核苷酸」及「寡核苷酸」可互換使用。其指任何長度之核苷酸(去氧核糖核苷酸或核糖核苷酸)之聚合物形式,或其類似物。聚核苷酸可具有任何三維結構,且可執行任何已知或未知的功能。以下為聚核苷酸之非限制性實例:基因或基因片段之編碼或非編碼區、根據連接分析所定義之基因座(loci/locus)、外顯子、內含子、信使RNA(mRNA)、轉移RNA、核糖體RNA、核糖核酸酶、cDNA、重組聚核苷酸、分支聚核苷酸、質體、載體、經分離之任何序列DNA、經分離之任何序列RNA、核酸探針及引子。聚核苷酸可包含經修飾之核苷酸,諸如甲基化核苷酸及核苷酸類似物。若存在,可在聚合物組裝之前或之後賦予核苷酸結構之修飾。核苷酸序列可能間雜有非核苷酸組分。可在聚合之後,諸如藉由與標記組分結合而進一步修飾聚核苷酸。
術語「聚核苷酸之補體」指示與參考序列相比具有互補鹼基序列及相反定向之聚核苷酸分子,使得其可與參考序列以完整保真度雜交。
應用於聚核苷酸之「重組」意謂聚核苷酸為可包括活體外選殖、限制及/或接合步驟之各種組合,及引起可潛在地在宿主細胞中表現之構築體的其他程序的產物。
術語「基因」或「基因片段」在本文中可互換使用。其係指含有至少一個能夠在經轉錄及轉譯之後編碼特定蛋白質之開放閱讀框架的聚核苷酸。基因或基因片段可為基因體或cDNA,只要聚核苷酸含有至少一個可覆蓋整個編碼區或其區段之開放閱讀框架即可。「融合基因」為由至少兩種連接在一起之異源聚核苷酸構成之基因。
「同源」或「同源性」係指兩個或更多個聚核苷酸序列之間或兩個或更多個多肽序列之間的序列類似性或互換性。當使用諸如BestFit之程式來測定兩種不同胺基酸序列之間的序列一致性、類似性或同源性時,可使用預設設定,或可選擇適當計分矩陣,諸如blosum45或blosum80以使一致性、類似性或同源性評分最佳化。較佳地,同源聚核苷酸為在如本文所定義之嚴格條件下雜交且與彼等序列相比,具有至少70%、較佳地至少80%、更佳地至少90%、更佳地95%、更佳地97%、更佳地98%且甚至更佳地99%序列一致性之彼等聚核苷酸。
術語「嚴格條件」或「嚴格雜交條件」包括指聚核苷酸將在相比於其他序列可偵測地更大的程度上雜交至其靶序列(例如超過背景至少2倍)之條件。一般而言,雜交之嚴格程度在某種程度上表現為與進行洗滌步驟的溫度及鹽濃度有關。通常,嚴格條件將係,在pH 7.0至8.3且溫度至少約為30℃下,鹽濃度小於約1.5 M Na離子,通常約為0.01至1.0 M Na離子濃度(或其他鹽)。對於短聚核苷酸(例如,10至50個核苷酸),至少約為60℃。對於長聚核苷酸(例如,大於50個核苷酸),例如,「嚴格條件」可包括在37℃下在50%甲醯胺、1 M NaCl、1% SDS中雜交,以及在60至65℃下在0.1×SSC/1% SDS中洗滌三次,各15分鐘。替代地,可使用約65℃、60℃、55℃或42℃的溫度。SSC濃度可在約0.1至2×SSC之間變化,其中SDS以約0.1%存在。此類洗滌溫度通常對於特定序列在界定離子強度及pH下選擇為低於熱熔點©約5℃至20℃。Tm為50%之目標序列雜交至完全匹配探針之溫度(在界定離子強度及pH下)。計算Tm之方程式及用於核酸雜交之條件為熟知的且可見於Sambrook,J.等人 (1989) Molecular Cloning: A Laboratory Manual , 第2 版, 第1-3卷,Cold Spring Harbor Press, Plainview N.Y.;特別參見第2卷及第9章。通常,阻斷試劑用於阻斷非特異性雜交。此類阻斷試劑包括例如約100-200 µg/ml之經剪切及變性之鮭魚精子DNA。亦可在特定環境下使用有機溶劑,諸如濃度為約35-50% v/v之甲醯胺,諸如用於RNA:DNA雜交。此等洗滌條件之有用變化形式將為一般熟習此項技術者顯而易知。
應用於聚核苷酸序列之術語「一致性百分比」及「一致性%」係指使用標準化算法比對之至少兩個聚核苷酸序列之間的殘基匹配之百分比。此類演算法可以標準化及可再現方式在進行比較之序列中插入間隙以使兩個序列之間的比對最佳化,且因此達成兩個序列之更有意義的比較。一致性百分比可在整個界定聚核苷酸序列之長度上量測,例如如由特定SEQ ID編號所定義,或可在較短長度上量測,例如在獲自較大界定聚核苷酸序列之片段,例如至少45、至少60、至少90、至少120、至少150、至少210或至少450個連續殘基之片段的長度上量測。此類長度僅為例示性的,且應理解,由本文在表格、圖式或序列表中顯示之序列所支持之任何片段長度可用於描述可量測百分比一致性之長度。
相對於本文中所鑑別之多肽序列的「百分比(%)胺基酸序列一致性」定義為在對比序列且必要時引入間隙以實現最大序列一致性百分比之後,與第二參考多肽序列或其部分之胺基酸殘基一致的查詢序列中之胺基酸殘基的百分比,且不考慮任何保守取代作為序列一致性之一部分。出於判定胺基酸序列一致性百分比之目的,可以在此項技術內之各種方式達成比對,例如使用公開可獲得的電腦軟體,諸如BLAST、BLAST-2、ALIGN或Megalign(DNASTAR)軟體。熟習此項技術者可測定用於量測比對之適當參數,包括用於達成所比較序列之全長內之最大比對所需的任何演算法。一致性百分比可在整個界定多肽序列之長度上量測,例如如由特定SEQ ID編號所定義,或可在較短長度上量測,例如在獲自較大界定多肽序列之片段,例如至少15、至少20、至少30、至少40、至少50、至少70或至少150個連續殘基之片段的長度上量測。此類長度僅為例示性的,且應理解,由本文在表格、圖式或序列表中顯示之序列所支持之任何片段長度可用於描述可量測百分比一致性之長度。
如本文在多肽之上下文中所用的術語「非重複性」係指肽或多肽序列中缺乏或具有有限程度之內部同源性。術語「基本上非重複」可意謂例如序列中存在少數或不存在四個連續胺基酸之實例,該等胺基酸為一致胺基酸類型或多肽具有10或更小的子序列分值(下文所定義)或不存在構成多肽序列之序列模體之N端至C端的次序之模式。如本文在多肽之上下文中所用的術語「重複性」係指肽或多肽序列中內部同源性之程度。相比之下,「重複」序列可以含有短胺基酸序列的多個一致複本。舉例而言,相關多肽序列可分成n聚體序列且可計數一致序列之數目。高度重複序列含有大部分一致序列,而非重複序列含有少數一致序列。在多肽之上下文中,序列可含有具有規定或可變長度或模體之較短序列的多個複本,其中模體本身具有非重複序列,使得全長多肽基本上非重複。量測非重複性之多肽長度可在3個胺基酸至約200個胺基酸、約6至約50個胺基酸或約9至約14個胺基酸之間變化。用於聚核苷酸序列之上下文中之「重複性」係指序列之內部同源性程度,諸如給定長度之一致核苷酸序列的頻率。重複性可例如藉由分析相同序列之頻率來量測。
「載體」為較佳在適當宿主中自主複製之核酸分子,其將插入之核酸分子傳遞至宿主細胞中及/或之間。術語包括主要用於將DNA或RNA插入至細胞中之載體、主要用於複製DNA或RNA之載體的複製品及用於DNA或RNA轉錄及/或轉譯之表現載體。亦包括提供超過一種以上功能之載體。「表現載體」為當引入至適當宿主細胞中時,可經轉錄及轉譯成多肽之聚核苷酸。「表現系統」通常意謂由可用以產生所需表現產物之表現載體構成的適合的宿主細胞。
應用於多肽之「血清降解抗性」係指多肽耐受血液或其組分中之降解的能力,其通常涉及血清或血漿中之蛋白酶。可藉由組合蛋白質與人類(或視需要未小鼠、大鼠、猴)血清或血漿,通常在數天(例如0.25、0.5、1、2、4、8、16天)範圍內,通常在約37℃下量測血清降解抗性。此等時間點之樣品可在西方墨點分析上運行且蛋白質用抗體偵測。抗體可為蛋白質中之標籤。若蛋白質在西方墨點分析上顯示單一譜帶,其中蛋白質之大小與注射之蛋白質相同,則未發生降解。在此例示性方法中,如由西方墨點法或等效技術判定的50%蛋白質降解之時間點為蛋白質之血清降解半衰期或「血清半衰期」。
如本文中所使用之術語「t
1 / 2」意指被計算為ln(2)/K
el之終末半衰期。K
el為藉由對數濃度對比時間曲線之終端線性部分的線性回歸所計算的終端消除速率常數。半衰期通常係指活有機體中沈積之投與物質的一半數量藉由正常生物過程代謝或消除所需的時間。術語「t
1 / 2」、「終末半衰期」、「消除半衰期」及「循環半衰期」在本文中可互換使用。
「表觀分子量因數」或「表觀分子量」係指由特定胺基酸序列展現之表觀分子量相對增加或減小的量度的相關術語。使用尺寸排阻層析法(SEC)及類似方法(與球狀蛋白質標準物相比)測定表觀分子量且以「表觀kD」單元量測。表觀分子量因數為表觀分子量與實際分子量之間的比率;後者係藉由基於胺基酸組合物,相加組合物中之每種類型的胺基酸的分子量來計算。
「流體動力學半徑」或「斯托克斯半徑(Stokes radius)」為溶液中之分子的有效半徑(以nm為單位之R
h),藉由假設其為在溶液中移動且受溶液之黏度抵抗之物體來量測。在本發明之實施例中,XTEN融合蛋白之流體動力學半徑量測與『表觀分子量因數』相關,其為更直觀的量測。蛋白質之「流體動力學半徑」影響其於水溶液中之擴散速率以及其在大分子凝膠中遷移之能力。蛋白質之流體動力學半徑係藉由其分子量以及其結構(包括形狀及緊密性)來測定。測定流體動力學半徑之方法為此項技術中熟知,諸如藉由使用尺寸排阻層析法(SEC),如美國專利第6,406,632號及第7,294,513號中所描述。大多數蛋白質具有球狀結構,其為最緊密三維結構,蛋白質可具有最小流體動力學半徑。一些蛋白質採用無規及開放、非結構化或『線性』構形且因此具有與類似分子量之典型球狀蛋白相比大得多的流體動力學半徑。
「生理條件」係指活宿主中之條件集合以及活體外條件,包括模擬活個體之彼等條件之溫度、鹽濃度、pH。已建立用於活體外分析之生理學相關條件的宿主。一般而言,生理緩衝液含有生理濃度之鹽且經調節至約6.5至約7.8,且較佳地約7.0至約7.5範圍內之中性pH。多種生理緩衝液在Sambrook等人中列出。(1989年)。生理學相關溫度在約25℃至約38℃範圍內,且較佳在約35℃至約37℃範圍內。
「反應性基團」為可耦合至第二反應性基團之化學結構。反應性基團之實例為胺基、羧基、硫氫基、羥基、醛基、疊氮基。一些反應性基團可經活化以促進與第二反應性基團偶合。活化之實例為羧基與碳化二亞胺之反應、羧基轉化為活化酯或羧基轉化為疊氮化物官能基。
「控釋劑」、「緩釋劑」、「儲庫型長效製劑(depot formulation)」或「持續釋放劑」可互換地使用,係指能夠使本發明之多肽釋放持續時間相對於當在無藥劑存在下投與多肽時釋放持續時間延長的藥劑。本發明之不同實施例可具有不同釋放速率,產生不同治療量。
術語「抗原」、「目標抗原」或「免疫原」在本文中可互換使用,係指抗體片段或基於抗體片段之治療劑結合至或具有結合特異性之結構或結合決定子。
如本文所用之術語「有效負載」係指具有生物或治療活性之蛋白質或肽序列;小分子之藥效團的對應物。有效負載之實例包括但不限於細胞介素、酶、激素及血液及生長因子。有效負載可進一步包含遺傳融合或化學結合部分,諸如化學治療劑、抗病毒化合物、毒素或造影劑。此等結合部分可經由可能為可裂解或不可裂解之連接子接合至多肽之其餘部分。
如本文所用,術語「拮抗劑」包括部分或完全阻斷、抑制或中和本文所揭示之天然多肽之生物活性的任何分子。鑑定多肽之拮抗劑的方法可包含使天然多肽與候選拮抗劑分子接觸及量測通常與天然多肽相關之一或多種生物活性的可偵測變化。在本發明之上下文中,拮抗劑可包括蛋白質、核酸、碳水化合物、抗體或任何其他降低生物活性蛋白之效應的分子。
術語「促效劑」以最廣泛意義使用且包括任何模擬本文所揭示之天然多肽之生物活性的分子。適合之促效劑分子特別包括促效劑抗體或抗體片段、天然多肽之片段或胺基酸序列變異體、肽、有機小分子等。鑑別天然多肽之促效劑的方法可包含使天然多肽與候選促效劑分子接觸及量測通常與天然多肽相關之一或多種生物活性的可偵測變化。
出於本文中之目的,「活性」係指與相應天然生物活性蛋白之組分一致的融合蛋白的組分的作用或效應,其中「生物活性」係指活體外或活體內生物功能或效應,包括但不限於受體結合、拮抗劑活性、促效劑活性或細胞或生理學反應。
如本文所用,「治療(treatment/treating)」或「緩解」或「改善」在本文中可互換使用。此等術語係指獲得有益或所希望之結果之方法,該等結果包括但不限於治療益處及/或預防益處。「治療益處」意謂根除或減輕所治療的潛在病症。因此,舉例而言,治療係指減輕疾病或病況或疾病或病況之症狀的影響之方法。因此,在所揭示之方法中,治療可指至少約10%、至少約20%、至少約30%、至少約40%、至少約50%、至少約60%、至少約70%、至少約80%、至少約90%或實質上完全降低已建立之疾病或病況或疾病或病況之症狀的嚴重程度。舉例而言,若個體之疾病之一或多種症狀相較於對照組減少10%,則將用於治療疾病之方法視為治療。因此,與天然或對照水準相比,降低可為10%、20%、30%、40%、50%、60%、70%、80%、90%、100%或10%與100%之間的任何降低百分比。此外,治療益處係藉由與潛在病症病況相關之一或多種生理症狀之根除或改善,使得在個體中觀測到改良來達成,儘管如此,個體仍可能罹患潛在病症。出於預防益處,組合物可向處於罹患特定疾病或病況之風險下的個體投與,或向報導疾病之一或多種生理症狀但可能尚未作出此疾病之診斷的個體投與。應理解,治療未必係指疾病、病況或疾病或病況之症狀之治癒或完全去除。
如本文所用,「治療效應」係指生理效應,包括但不限於治癒、緩解、改善或預防人類或其他動物之疾病或病況,或以其他方式增強人類或動物之物理或精神健康,其除誘導產生針對生物活性蛋白質所具有之抗原決定基之抗體的能力以外,由本發明之融合多肽引起。治療有效量之確定完全在熟習此項技術者之能力範圍內,尤其根據本文所提供之詳細揭示內容來確定。
如本文中所用,術語「治療有效量」及「治療有效劑量」係指單獨或作為融合蛋白組合物之一部分的生物活性蛋白之量,當以一個或重複劑量向個體投與時能夠對疾病狀態或病況之任何症狀、態樣、量測參數或特徵具有任何可偵測的有益作用。此類作用不必絕對有益。疾病或病況可指病症或疾病。
如本文所用,術語「治療有效劑量方案」係指單獨或作為融合蛋白組合物之一部分連續投與劑量之生物活性蛋白的排程,其中劑量以治療有效量給予以對疾病狀態或病況之任何症狀、態樣、量測參數或特徵產生持續有益作用。
如本文所用,疾病或病症之術語「預防(prevent/preventing/prevention)」係指例如投與嵌合多肽或編碼嵌合多肽之核酸序列的操作,該操作發生在個體開始展示一或多種疾病或病症之症狀之前或大約相同的時間,其抑制或延遲疾病或病症之一或多種症狀的發作或惡化。
如本文所用,提及「減少」、「降低」或「抑制」包括與適合對照水準相比,改變至少約10%、至少約20%、至少約30%、至少約40%、至少約50%、至少約60%、至少約70%、至少約80%、至少約90%或以上。此類術語可包括(但未必包括)功能或特性(諸如促效劑活性)之完全消除。
「減弱之細胞介素受體促效劑」為一種細胞介素受體促效劑,其與細胞介素受體之天然存在促效劑相比,具有降低之受體促效劑活性。與受體之天然存在促效劑相比,減弱之細胞介素促效劑可具有至少約10倍、至少約50倍、至少約100倍、至少約250倍、至少約500倍、至少約1000倍或更低之促效劑活性。當含有如本文所描述之細胞介素多肽之XPAC描述為「減弱」或具有「減弱之活性」時,其意謂XPAC為減弱之細胞介素受體促效劑。
一般技術
除非另外指明,否則本發明之實踐採用免疫學、生物化學、化學、分子生物學、微生物學、細胞生物學、基因體學及重組DNA之習知技術,該等技術在此項技術之技能內。參見Sambrook, J.等人., 「Molecular Cloning: A Laboratory Manual」, 第3版, Cold Spring Harbor Laboratory Press, 2001;「Current protocols in molecular biology」, F. M. Ausubel,等人編.,1987;「Methods in Enzymology」系列, Academic Press, San Diego, CA.;「PCR 2: a practical approach」, M.J. MacPherson, B.D. Hames及G.R. Taylor編., Oxford University Press, 1995;「Antibodies, a laboratory manual」 Harlow, E.及Lane, D.編., Cold Spring Harbor Laboratory,1988;「Goodman & Gilman's The Pharmacological Basis of Therapeutics」, 第11版, McGraw-Hill, 2005;及Freshney, R.I., 「Culture of Animal Cells: A Manual of Basic Technique」, 第4版, John Wiley & Sons, Somerset, NJ, 2000,其內容以引用方式全文併入本文。
用於XPAC之細胞介素
一般而言,細胞介素之治療用途很大程度上受到其全身毒性限制。例如,TNF最初由於其誘導一些腫瘤出血性壞死之能力及其對不同腫瘤株系之活體外細胞毒素作用而被發現,但其隨後被證明具有強促炎性活性,其可在過度產生條件之情況下危險地影響人體。由於全身毒性係在人類中使用藥理學活性量之細胞介素的基本問題,因此現在評估新穎衍生物及治療策略,旨在降低此類生物效應子之毒性效應同時保持其治療功效。
用於產生XPAC之較佳細胞介素為介白素-12(IL-12)。IL-12為兩個獨立編碼次單元(p35及p40)之二硫鍵連接的異二聚體,其共價連接以產生所謂的生物活性異二聚體(p70)分子。除形成異二聚體(IL-12及IL-23)之外,p40次單元亦作為單體(p40)及同二聚體(p40
2)分泌。此項技術中已知,用連接p35與p40次單元之連接子合成呈單鏈之異二聚體保持異二聚體之完整生物活性。IL-12在對感染之早期發炎反應及Th1細胞產生中起關鍵作用,其促進細胞介導之免疫性。已發現IL-12之過度產生可能對宿主有害,因為其涉及多種自體免疫性發炎疾病(例如MS、關節炎、1型糖尿病)之發病機制。
IL-12受體(IL-12R)為異二聚錯合物,其由在活化T細胞及自然殺手細胞表面上表現之IL-12Rβ1及IL-12Rβ2鏈組成。IL-12Rβ1鏈結合至IL-12p40次單元,而IL-12p35結合IL-12Rβ2賦予胞內信號傳導能力。經由IL-12R之信號轉導誘發詹納斯激酶(Janus kinase,Jak2)及酪胺酸激酶(Tyk2)磷酸化,磷酸化且活化信號轉導與轉錄活化因子(STAT)1、STAT3、STAT4及STATS。IL-12之特異性細胞效應主要係由於STAT4之活化。IL-12誘導自然殺手及T細胞產生細胞介素,特別係干擾素(IFN)γ,其介導IL-12之許多促炎性活性,包括CD4+T細胞向Th1表型之分化。
IL-2在免疫系統中發揮刺激及調節功能兩者,且與共同γ鏈細胞介素家族之其他成員一起,係免疫穩態的核心。IL-2藉由結合至IL-2受體(IL-2R)來介導其作用,該等受體由任一由IL-2Rα(CD25)、IL-2Rβ(CD122)及IL-2R-γ(γ-c,CD132鏈或二聚體βγ IL-2R構成之三聚體受體組成。IL-2R變異體均能夠在IL-2結合時傳輸信號。然而,與二聚體βγ IL-2R(3)相比,三聚體αβγIL-2R對IL-2之親和力高約10至100倍,暗示CD25賦予IL2與其受體之結合高親和力但對於信號轉導並不至關重要。在活化T細胞及CD4 +叉頭框P3(FoxP3)+ T調節細胞(Treg)上發現三聚體IL-2R,其在活體外及活體內對IL-2敏感。反之,抗原經歷之(記憶)CD8+、CD44高記憶表型(MP)CD8+及自然殺手(NK)細胞具有高水準的二聚體βγIL-2R,且此等細胞亦活體外及活體內對IL-2產生劇烈反應。
高親和力IL-2R的表現對於賦予T細胞以對活體內短暫可用的低濃度IL-2起反應為至關重要的。IL-2Rα表現在初始及記憶T細胞上不存在,但在抗原活化之後經誘導。IL-2Rβ組成性地由NK、NKT及記憶CD8+ T細胞表現,但在抗原活化之後亦在初始T細胞上誘導。γ-鏈受嚴格調控的程度低得多且由所有淋巴細胞組成性表現。一旦高親和力IL-2R由抗原誘導,則IL-2R信號傳導在某種程度上經由Il2ra轉錄之Stat5依賴性調節來上調IL-2Rα之表現。此過程表示維持高親和力IL-2R表現及維持IL-2信號傳導同時仍保持IL-2來源的一種機制。
介白素-15(IL-15)(細胞介素4-α-螺旋束家族之另一成員)亦已顯現為用於治療癌症的免疫調節劑。IL-15起初經由IL-15Rα捕獲,其表現於抗原呈現樹突狀細胞、單核球及巨噬細胞上。IL-15展現較寬泛活性且經由IL-15/IL-2-R-β(CD122)及共同γ鏈(CD132)經由信號傳導來誘導T、B及自然殺手(NK)細胞之分化及增殖。其亦增強CD8+ T細胞之溶胞活性且誘導持久的抗原經歷之CD8+CD44記憶T細胞。IL-15刺激B細胞分化及免疫球蛋白合成且誘導樹突狀細胞成熟。其並不刺激免疫抑制性T調節細胞(Treg)。因此,在腫瘤微環境中選擇性增強IL-15活性可增強先天性及特異性免疫性且對抗腫瘤。
介白素-7(IL-7)亦屬於IL-2/IL-15家族,為充分表徵之多效性細胞介素,且由基質細胞、上皮細胞、內皮細胞、纖維母細胞、平滑肌細胞及角質細胞表現,且在活化後由樹突狀細胞表現(Alpdogan等人, 2005)。儘管其最初描述為前驅體B淋巴球之生長及分化因子,但後續研究已展示IL-7極其涉及T淋巴球發育及分化。介白素-7信號傳導對最佳CD8 T細胞功能、穩態及記憶建立至關重要(Schluns等人, 2000);其為大部分T細胞亞群之存活期所需的,且其表現已經提議對於調節T細胞數目至關重要。
IL-7在細胞毒性化療後在癌症患者中增強免疫復原方面具有潛在作用。IL-7療法增強免疫復原且可藉由促進較少數目之近期胸腺遷移細胞的外周擴張來增強甚至有限胸腺功能。因此,IL-7療法可潛在地修復已由細胞毒性化療耗盡之患者之免疫系統且可為XPAC生產之有吸引力的候選物。
調節性T細胞主動抑制免疫系統活化且預防病理性自身反應性及隨之而來的自體免疫性疾病。研發選擇性地活化調節性T細胞以用於治療自體免疫性疾病之藥物及方法為大量研究的主題,且直至本發明研發出可在發炎部位處選擇性地傳遞活性介白素之前,已在很大程度上失敗。調節性T細胞(Treg)係抑制其他免疫細胞之活性的一類CD4+CD25+ T細胞。Treg對免疫系統穩態為的核芯,且在維持自體抗原耐受性及調節針對外來抗原之免疫反應中起主要作用。多種自體免疫性及發炎性疾病,包括1型糖尿病(T1D)、全身性紅斑性狼瘡症(SLE)及移植物抗宿主病(GVHD)已展示出在Treg細胞數目或Treg功能山的不足。
因此,對提高Treg細胞之數目及/或功能之療法的研發存在極大關注。一種方法為使用低劑量介白素-2(IL-2)治療。Treg細胞特徵性地表現高親和力IL-2受體之高構成性水準,IL2Rαβγ由次單元IL2Rα(CD25)、IL2Rβ(CD122)及IL2Rγ(CD132)組成,且Treg細胞生長已被顯示依賴於IL-2。反之,使用IL-2亦實現免疫活化,且已審批通過重組IL-2(Proleukin®)來治療某些癌症。高劑量IL-2用於治療患有轉移性黑色素瘤及轉移性腎細胞癌之患者,對總存活率具有長期影響。
低劑量IL-2治療慢性GVHD及HCV相關之自體免疫性血管炎患者的臨床試驗證明Treg水準及臨床功效之徵象增加。使用所謂低劑量IL-2之基本原理為利用高IL-2親和力之三聚體IL-2受體,該三聚體IL-2受體組成性表現於Treg上,而留下不表現處於不活化狀態下之高親和力受體的其他T細胞。在此等試驗中所用之IL-2之重組形式的Proleukin®(Prometheus Laboratories, San Diego, Calif.)與高毒性相關。高劑量下之阿地介白素(aldesleukin)經批准用於治療轉移性黑色素瘤及轉移性腎癌,但其副作用極嚴重以至於其僅在能夠獲得重症監護之醫院環境中推薦其使用。
自體免疫性疾病中IL-2之臨床試驗已採用較低劑量之IL-2以靶向Treg細胞,因為Treg細胞由於其IL2R α之表現而對比許多其他免疫細胞類型更低濃度之IL-2起反應。然而,即使此等較低劑量亦會產生安全性及耐受性問題,且所用治療已長期或在間歇性5天治療過程中採用每日皮下注射。因此,需要增強Treg細胞數目及功能之自體免疫性疾病療法,該自體免疫性疾病療法比IL-2更特定地靶向Treg細胞,其為安全且更可耐受的,且以更低頻率投與。IL-2之此低治療窗在整個其他細胞介素療法中發揮作用。
改良針對自體免疫性疾病之基於細胞介素之療法的治療指數的一種方法係使用相對於其他免疫細胞對Treg細胞具有選擇性之IL-2變異體。IL-2受體表現於多種不同免疫細胞類型,包括T細胞、NK細胞、嗜伊紅血球及單核球上,且此廣泛表現模式可能有助於其對免疫系統的多效性作用及高全身毒性。特定言之,活化T效應細胞表現IL2Rαβγ,肺部上皮細胞亦如此。但活化T效應細胞直接與下調及控制免疫反應的目標背道而馳,且活化肺上皮細胞導致IL-2之已知劑量限制性副作用,包括肺水腫。實際上,高劑量IL-2免疫療法之主要副作用為血管滲漏症候群(VLS),其導致血管內流體在諸如肺及肝之器官中積累,隨後出現肺水腫及肝細胞損傷。除停服IL-2之外,不存在VLS之療法。為了避免VLS,已在患者中測試低劑量IL-2方案,然而以次最佳的治療結果為代價。
利用除IL-2以外之介白素細胞介素進行治療之情況甚至有限。IL-15呈現類似於IL-2之免疫細胞刺激活性但無相同抑制作用,因此使得其為一種有前景的免疫治療候選物。重組人類IL-15用於治療轉移性惡性黑色素瘤或腎細胞癌之臨床試驗表明免疫細胞分佈、增殖及活化發生顯著變化且表明潛在的抗腫瘤活性。已知IL-15療法與非所要及毒性效應相關聯,諸如惡化某些白血病、移植物抗宿主病、低血壓、血小板減少症及肝損傷。
IL-7促進胸腺中之淋巴球發育且維持初始及記憶T細胞穩態在外周中的存活。此外,其對淋巴結(LN)之器官發生及用於維持募集至次級淋巴器官(SLO)中之經活化T細胞至關重要。在IL-7之臨床試驗中,接受IL-7之患者展示CD4+及CD8+ T細胞兩者之增加,調節性T細胞數目無顯著增加,如FoxP3表現所監測。在2006、2008及2010年報導之臨床試驗中,向患有不同種類之癌症(諸如轉移性黑色素瘤或肉瘤)之患者皮下注射不同劑量之IL-7。除短暫發熱及輕度紅斑外,幾乎未見毒性。CD4+及CD8+ T細胞兩者之循環水準顯著增加且Treg數目減少。IL-7療法後TCR基因譜多樣性增加。然而,未充分評估IL-7之抗腫瘤活性。結果表明IL-7療法可增強及拓寬免疫反應。
IL-12為多效性細胞介素,其在先天性及適應性免疫性之間產生互連。IL-12首先描述為由PMA誘導之EBV轉化之B細胞株分泌的因子。基於其作用,IL-12已被指定為細胞毒性淋巴球成熟因子及自然殺手細胞刺激因子。由於彌合了先天性及適應性免疫,且有效刺激了IFNγ(一種協調抗癌防禦自然機制的細胞介素)的產生,IL-12似乎為人類腫瘤免疫療法的理想候選物。然而,在臨床研究中與IL-12全身投與相關之嚴重副作用以及此細胞介素的非常狹窄的治療指數顯著地阻礙了此細胞介素在癌症患者的使用。IL-12療法(其中細胞介素的遞送係腫瘤靶向的,其可能會減少IL-12療法的一些先前問題)的方法目前正在癌症的臨床試驗中。
IL-2作為促效劑直接使用以結合IL-2R且調節免疫反應在治療學上存在問題,因為其充分記載的治療風險,例如其短血清半衰期及高毒性。此等風險亦限制了其他細胞介素的治療性開發及使用。需要降低此等風險的新型細胞介素。本文所揭示的包含條件性活性IL-12及其他細胞介素之組合物及方法,該等細胞介素經設計以解決與習知細胞介素療法相關之風險且提供許多所需免疫調節療法。
細胞介素,包括介白素(例如IL-2、IL-7、IL-12、IL-15、IL-18、IL-21、IL-23)、干擾素(IFNS,包括IFNα、IFNβ及IFNγ)、腫瘤壞死因子(例如TNFα、淋巴毒素)、轉型生長因子(例如TNFβ1l、TGFβ2、TGFβ3)、趨化介素(C-X-C模體趨化介素10(CXCL10)、CCL19、CCL20、CCL21)及顆粒球巨噬細胞群落刺激因子(GM-CS)在向患者投與時具有極強的效力。用此等分子形成XPAC可使其更容易用於治療環境。
如本文所用,「趨化介素」意謂在鄰近反應性細胞細胞介素中誘導定向趨化性之能力的小細胞介素家族,可提供強有力療法,但伴隨有難以在臨床上控制且已限制細胞介素之臨床用途的非所需效應。本揭示案係關於可用於具有減少或消除不合需要的效應之患者中的細胞介素之新穎形式。特定言之,本揭示案係關於醫藥組合物,其包括嵌合多肽(XPAC)、編碼XPAC之核酸及前述之醫藥調配物,改醫藥調配物含有細胞介素或細胞介素之活性片段或突變蛋白,該等細胞介素與相應細胞介素相比具有降低之細胞介素受體活化活性。然而,在所選條件下或在所選生物環境中,嵌合多肽活化其同源受體,通常具有與相應天然存在之細胞介素相同或更高的效力。如本文所描述,此通常使用細胞介素阻斷部分來實現,該部分在一般條件下而非在所選條件下阻斷或抑制細胞介素、其活性片段或突變蛋白之受體活化功能,諸如存在於細胞介素活性的所需位點(例如,炎症部位或腫瘤)之彼等。
雖然本申請案使用IL-12作為例示性細胞介素進行例示,但熟習此項技術者應瞭解本文所提供之教示內容可容易地適於且描述且能夠使用由其他細胞介素、片段及突變蛋白形成之XPAC,諸如IL-2、IL-7、IL-12、IL-15、IL-18、IL-21、IL-23、IFNα、IFNβ、IFNγ、TNFα、淋巴毒素、TGF-β1、TGFβ2、TGFβ3、GM-CSF、CXCL10、CCL19、CCL20、CCL21及前述任一者之功能片段或突變蛋白。
各種元素確保本發明之XPAC中之細胞介素之遞送及活性優先在所需細胞介素活性位點,且經由XTEN化嚴重限制細胞介素之全身性曝露,此允許相關細胞介素之血清半衰期延長。在此血清半衰期延長策略中,XPAC可循環延長時間(優先1至2週或更多週),但已裂解XTEN序列之活化版本具有細胞介素之典型血清半衰期。
藉由與XPAC比較,由於分佈至全身細胞外空間,靜脈內投與之潛在細胞介素之血清半衰期僅為約10分鐘。隨後,細胞介素藉由腎代謝,半衰期為2.5小時。
在本發明之一些實施例中,XPAC包含釋放區段,其在作用部位處裂解(例如藉由發炎特異性或腫瘤特異性蛋白酶),由此在所需部位釋放細胞介素之全部活性,且亦將其與未裂解(XPAC)版本的半衰期延長分離。在此類實施例中,完全活性及游離細胞介素將具有極不同的藥物動力學(pK)特性--半衰期為數小時而不為數週。另外,對活性細胞介素之暴露限於所需細胞介素活性之部位(例如發炎性部位或腫瘤微環境),且全身性暴露於活性細胞介素以及相關毒性及副作用降低。
自細胞介素產生XPAC為一種優雅機制,藉由其改良細胞介素作為免疫刺激劑(例如用於治療癌症)的用途。舉例而言,在此態樣中,細胞介素(例如IL-2、IL-7、IL-12、IL-15、IL-18、IL-21、IL-23、IFNα、IFNβ及IFNγ、TNFα、淋巴毒素、TGFβ1、TGFβ2、TGFβ3、GM-CSF、CXCL10、CCL19、CCL20及CCL21)之藥物動力學及/或藥效動力學可調整以最大限度地活化效應細胞(例如效應T細胞、NK細胞)及/或細胞毒性免疫反應促進細胞(例如誘導樹突狀細胞成熟)在所要活性部位,諸如在腫瘤或腫瘤微環境中,但較佳不為全身性的。
因此,本文提供包含XPAc之醫藥組合物,該XPAc由至少一種細胞介素多肽構成,諸如介白素(例如IL-2、IL-7、IL-12、IL-15、IL-18、IL-21、IL-23)、干擾素(IFNS,包括IFNα、IFNβ及IFNγ)、腫瘤壞死因子(例如TNFα、淋巴毒素)、轉型生長因子(例如TNFβ1、TGFβ2、TGFβ3)、趨化介素(例如CXCL10、CCL19、CCL20、CCL21)及顆粒球巨噬細胞群落刺激因子(GM-CS)及前述任一者之功能片段或突變蛋白。
較佳地,包括於本文中所揭示之XPAC中的細胞介素多肽(包括功能片段)不經突變或經工程改造以改變天然存在之細胞介素的特性,包括受體結合親和力及特異性或血清半衰期。然而,可接受胺基酸序列自天然存在(包括野生型)細胞介素之變化以促進選殖及達成所需表現量。
延伸重組多肽
本發明提供包含延伸重組多肽(「XTEN」或「XTENs」)之組合物。在一些實施例中,XTEN一般為延伸長度的多肽,其具有主要由小親水性胺基酸構成之非天然存在之實質上非重複序列,其中該序列在生理條件下具有較低程度或無二級或三級結構。
在本發明之一個態樣中,揭示適用作融合搭配物的XTEN多肽組合物,其可連接至生物活性蛋白(「BP」),產生BPXTEN融合蛋白(例如單體融合物)。XTEN可具有作為融合蛋白搭配物之效用,因為當連接至生物活性蛋白以產生融合蛋白時,其可賦予某些化學及醫藥特性。此類所需特性包括但不限於增強的藥物動力學參數及溶解度特徵,以及下文所描述之其他特性。此類融合蛋白組合物可具有治療某些疾病、病症或病況之效用,如本文所描述。如本文所用,「XTEN」特異性排除抗體或抗體片段,諸如單鏈抗體、輕鏈或重鏈之Fc片段。
在一些實施例中,XTEN為以單一序列形式使用時具有大於約100至約3000個胺基酸殘基、較佳大於400至約3000個殘基之長多肽,且當超過一個XTEN單元用於單一融合蛋白或結合物中時累積地具有大於約400至約3000個胺基酸殘基。在其他情況下,在不需要增加融合蛋白之半衰期但其中需要增加生物活性蛋白質融合搭配物之溶解度或其他物理/化學特性的情況下,可將短於100個胺基酸殘基,諸如約96個、或約84個、或約72個、或約60個、或約48個、或約36個胺基酸殘基之XTEN序列併入至具有BP之融合蛋白組合物中以實現特性。
XTEN與生物活性蛋白連接以產生本發明融合蛋白之選擇準則一般係關於XTEN之物理/化學特性及構形結構的屬性,該等屬性又可用於賦予融合蛋白增強之醫藥學及藥物動力學特性。本發明之XTEN可呈現以下有利特性中之一或多者:構形可撓性、增之水溶性、高程度之蛋白酶抗性、較低免疫原性、與哺乳動物受體之低結合及增加的流體動力(或斯托克(Stokes))半徑;可使其特別適用作融合蛋白搭配物之特性。包含可藉由XTEN增強之BP之融合蛋白的特性之非限制性實例包括增加之總體溶解度及/或代謝穩定性、降低之蛋白水解敏感性、降低之免疫原性、皮下或肌肉內投與時降低之吸收速率及增強之藥物動力學特性(諸如終末半衰期及曲線下面積(AUC)),在皮下或肌肉內注射之後較慢之吸收(相比於不連接至XTEN之BP),使得C
max較低,此轉而可引起BP之副作用的減少,總體而言,相較於不連接至XTEN之對應的BP組分,此可引起向個體投與之BPXTEN組合物之融合蛋白保持在治療窗內的時間段增加。
此項技術中已知多種用於測定蛋白質(諸如包含本發明XTEN之融合蛋白組合物)之物理/化學特性之方法及分析;特性,諸如二級或三級結構、溶解度、蛋白質聚集、熔融特性、污染及水含量。此類方法包括分析型離心、EPR、HPLC-離子交換、HPLC-尺寸排阻層析法、逆相HPLC、光散射、毛細電泳法、圓二色性、差示掃描熱量測定、螢光、HPLC-離子交換、HPLC-尺寸排阻、IR、NMR、拉曼光譜法(Raman spectroscopy)、折射法及UV/可見光譜法。其他方法揭示於Arnau等人, Prot Expr and Purif (2006) 48, 1-13中。在本發明中應用此等方法將在熟習此項技術者之掌握範圍內。
典型地,融合蛋白之XTEN組分經設計以在生理條件下表現得類似變性肽序列,儘管聚合物長度延伸。變性描述由肽主鏈之較大構形自由表徵的肽在溶液中之狀態。大部分肽及蛋白質在高濃度之變性劑存在下或在高溫下採用變性構形。呈變性構形之肽具有例如特徵性圓二色性(CD)譜且特徵在於不具有長程相互作用(如由NMR所測定)。「變性構形」及「非結構化構形」在本文中同義地使用。在一些情況下,本發明提供XTEN序列,其在生理條件下可類似於基本上不含二級結構之變性序列。在其他情況下,XTEN序列在生理條件下可基本上不含二級結構。如在此上下文中所用,「基本上不含」意謂XTEN序列之小於50%的XTEN胺基酸殘基有助於促成二級結構,如藉由本文所描述之手段量測或測定。如在此上下文中所使用之「基本上不含」意謂XTEN序列之至少約60%、或約70%、或約80%、或約90%、或約95%或至少約99%的XTEN胺基酸殘基不促成二級結構,如藉由本文所描述之手段量測或測定。
此項技術中已建立多種方法來辨別給定多肽中二級及三級結構之存在或不存在。特定言之,二級結構可以分光光度法,例如藉由「遠UV」光譜區(190-250 nm)中之圓二色性光譜法來量測。二級結構元件,諸如α-螺旋及β-摺疊,各自產生CD光譜之特徵性形狀及量值。二級結構亦可經由某些電腦程式或算法針對多肽序列預測,諸如熟知的Chou-Fasman演算法(Chou, P. Y.,等人 (1974)
Biochemistry, 13: 222-45)及Garnier-Osguthorpe-Robson(「GOR」)演算法(Garnier J, Gibrat JF, Robson B. (1996), GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol 266:540-553),如美國專利申請公開案第20030228309A1號中所描述。對於給定序列,演算法可預測存在一些二級結構或根本不存在,表示為形成例如α-螺旋或β-摺疊之序列之殘基的總數及/或百分比或預測導致無規捲曲形成之序列(其不具有二級結構)之殘基的百分比。
在一些情況下,本發明融合蛋白組合物中使用之XTEN序列可具有在0%至小於約5%範圍內的α-螺旋百分比,如藉由Chou-Fasman演算法所測定。在其他情況下,融合蛋白組合物之XTEN序列可具有在0%至小於約5%範圍內的β-摺疊百分比,如藉由Chou-Fasman演算法所測定。在一些情況下,融合蛋白組合物之XTEN序列可具有在0%至小於約5%範圍內之α-螺旋百分比及在0%至小於約5%範圍內之β-摺疊百分比,如藉由Chou-Fasman演算法所測定。在較佳實施例中,融合蛋白組合物之XTEN序列將具有小於約2%之α-螺旋百分比及小於約2%之β-摺疊百分比。在其他情況下,融合蛋白組合物之XTEN序列可具有高程度之無規捲曲百分比,如藉由GOR演算法所測定。在一些實施例中,XTEN序列可具有至少約80%、更佳至少約90%、更佳至少約91%、更佳至少約92%、更佳至少約93%、更佳至少約94%、更佳至少約95%、更佳至少約96%、更佳至少約97%、更佳至少約98%、且最佳至少約99%無規捲曲,如藉由GOR演算法所測定。
非重複序列
本發明組合物之XTEN序列可為基本上非重複的。一般而言,重複胺基酸序列具有聚集或形成高階結構之趨勢,如藉由天然重複序列(諸如膠原蛋白及白胺酸拉鏈)所例示,或形成接觸,從而產生結晶或假晶結構。相比之下,非重複序列聚集之低趨勢使得能夠設計具有相對較低帶電胺基酸頻率之長序列XTEN,若序列以其他方式重複,則該等帶電胺基酸將可能聚集。典型地,BPXTEN融合蛋白包含大於約100至約3000個胺基酸殘基,較佳大於400至約3000個殘基之XTEN序列,其中序列為基本上非重複的。在一個實施例中,XTEN序列可具有大於約100至約3000個胺基酸殘基,較佳大於400至約3000個胺基酸殘基,其中除非胺基酸為絲胺酸,否則序列中不存在三個相鄰胺基酸為相同胺基酸類型,在此情況下不超過三個相鄰胺基酸為絲胺酸殘基。在前述實施例中,XTEN序列將基本上為非重複的。
多肽或基因之重複性程度可藉由電腦程式或演算法或藉由此項技術中已知之其他方式量測。多肽序列中之重複性可例如藉由測定在多肽內出現之給定長度之較短序列的次數來評估。舉例而言,200個胺基酸殘基之多肽具有192個重疊9-胺基酸序列(或9聚體「框架」)及198個3聚體框架,但唯一9聚體或3聚體序列之數目將視序列內之重複量而定。可生成評分(下文中稱為「子序列評分」),其反映整個多肽序列中之子序列之重複程度。在本發明之上下文中,「子序列評分」意指多肽之200個連續胺基酸序列中各唯一3聚體框架發生次數之和除以200個胺基酸序列中唯一3聚體子序列的絕對數。在一些實施例中,本發明提供各自包含XTEN之BPXTEN,其中XTEN可具有小於12、更佳小於10、更佳小於9、更佳小於8、更佳小於7、更佳小於6且最佳小於5之子序列評分。在此段落中所描述之上文實施例中,具有小於約10(例如9、8、7等)之子序列分數的XTEN將為「基本上非重複的」。
XTEN之非重複特徵可賦予具有BP之融合蛋白與具有重複序列之多肽相比更大程度的溶解度及更少的聚集趨勢。此等特性可以促進包含XTEN之醫藥製劑的調配,該等醫藥製劑含有極高的藥物濃度,在一些情況下超過100 mg/ml。
此外,實施例之XTEN多肽序列經設計以具有較低程度之內部重複性,以便在向哺乳動物投與時降低或基本上消除免疫原性。由很大程度上限於三個胺基酸(諸如甘胺酸、絲胺酸及麩胺酸)之短重複模體構成之多肽序列在向哺乳動物投與時可引起相對較高的抗體效價,儘管此等序列中不存在所預測的T細胞抗原決定基。此可以由多肽之重複性質引起,因為已顯示,具有重複抗原決定基(包括蛋白質聚集物、交聯免疫原及重複碳水化合物)的免疫原具有高度免疫原性且可以引起例如B細胞受體之交聯,從而引起B細胞活化。(Johansson, J.,等人 (2007) Vaccine, 25 :1676-82;Yankai, Z.,等人 (2006) Biochem Biophys Res Commun, 345 :1365-71;Hsu, C. T.,等人 (2000) Cancer Res, 60:3701-5);Bachmann MF,等人 Eur J Immunol. (1995) 25(12):3445-3451)。
例示性序列模體
本發明涵蓋XTEN,其可包含多個較短序列之單元或模體,其中模體之胺基酸序列為非重複的。在設計XTEN序列時,發現儘管使用「建構組元(building block)」方法使用多聚化以創建XTEN序列的序列模體庫,但非重複準則可能被滿足。因此,雖然XTEN序列可由少至四種不同類型之序列模體之多個單元組成,因為模體本身一般由非重複胺基酸序列組成,但整個XTEN序列呈現基本上非重複。
在一個實施例中,XTEN可具有大於約100至約3000個胺基酸殘基、較佳大於400至約3000個殘基之非重複序列,其中XTEN序列的至少約80%、或至少約85%、或至少約90%、或至少約95%、或至少約97%、或約100%由非重疊序列模體組成,其中該等模體中之每一者具有約9至36個胺基酸殘基。在其他實施例中,XTEN序列之至少約80%、或至少約85%、或至少約90%、或至少約95%、或至少約97%、或約100%由非重疊序列模體組成,其中該等模體中之每一者具有9至14個胺基酸殘基。在另其他實施例中,XTEN序列組分之至少約80%、或至少約85%、或至少約90%、或至少約95%、或至少約97%、或約100%由非重疊序列模體組成,其中該等模體中之每一者具有12個胺基酸殘基。在此等實施例中,較佳地,序列模體主要由小親水性胺基酸構成,使得整個序列具有非結構化可撓性特徵。XTEN中可包括之胺基酸之實例為例如精胺酸、離胺酸、蘇胺酸、丙胺酸、天冬醯胺、麩醯胺酸、天冬胺酸、麩胺酸、絲胺酸及甘胺酸。由於密碼子最佳化、編碼序列模體之組裝聚核苷酸、蛋白質表現、表現蛋白質之電荷分佈及溶解度以及二級及三級結構等變量的測試,發現具有增強特徵之XTEN組合物主要包括甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)殘基,其中序列經設計為基本上非重複的。在一較佳實施例中,XTEN序列主要具有四至六種類型之胺基酸,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)或脯胺酸(P),其以基本上非重複序列排列,該序列長度大於約100至約3000個胺基酸殘基,較佳大於400至約3000個殘基。在一些實施例中,XTEN可具有大於約100至約3000個胺基酸殘基,較佳大於400至約3000個殘基之序列,其中至少約80%之序列由非重疊序列模體組成,其中該等模體中之每一者具有9至36個胺基酸殘基,其中該等模體中之每一者由4至6種類型的胺基酸組成,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中全長XTEN中任一種胺基酸類型的含量不超過30%。在其他實施例中,XTEN序列之至少約90%由非重疊序列模體組成,其中該等模體中之每一者具有9至36個胺基酸殘基,其中該等模體中之每一者由4至6種類型的胺基酸組成,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中全長XTEN中任一種胺基酸類型的含量不超過30%。在其他實施例中,XTEN序列之至少約90%由非重疊序列模體組成,其中該等模體中之每一者具有12個由4至6種類型的胺基酸組成的胺基酸殘基,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中全長XTEN中任一種胺基酸類型的含量不超過30%。在又其他實施例中,XTEN序列之至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%至約100%由非重疊序列模體組成,其中該等模體中之每一者具有12個胺基酸殘基,該等殘基由甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)組成,且其中全長XTEN中任一種胺基酸類型的含量不超過30%。
在另其他實施例中,XTEN包含超過約100至約3000個胺基酸殘基、較佳超過400至約3000個胺基酸殘基之非重複序列,其中序列之至少約80%、或至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%由具有9至14個胺基酸殘基的非重疊序列模體組成,其中該等模體由4至6種類型之胺基酸組成,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中任何一個模體中之任何兩個連續胺基酸殘基之序列在序列模體中重複不超過兩次。在其他實施例中,XTEN序列之至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%由具有12個胺基酸殘基的非重疊序列模體組成,其中該等模體由4至6種類型之胺基酸組成,該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中任何一個序列模體中之任何兩個連續胺基酸殘基之序列在序列模體中重複不超過兩次。在其他實施例中,XTEN序列之至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%由具有12個胺基酸殘基的非重疊序列模體組成,其中該等模體由甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)組成,且其中任何一個序列模體中之任何兩個連續胺基酸殘基之序列在序列模體中重複不超過兩次。在又其他實施例中,XTEN由12個胺基酸序列模體組成,其中該等胺基酸選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P),且其中任何一個序列模體中之任何兩個連續胺基酸殘基之序列在序列模體中重複不超過兩次,且其中全長XTEN中任一種胺基酸類型的含量不超過30%。在此段落中所描述之上文前述實施例中,XTEN序列將為基本上非重複的。
在一些情況下,本發明提供包含大於約100至約3000個胺基酸殘基、較佳大於400至約3000個殘基之非重複XTEN序列的組合物,其中序列之至少約80%、或至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%至約100%由選自
表 1之胺基酸序列的兩個或更多個非重疊序列模體的多個單元組成。在一些情況下,XTEN包含非重疊序列模體,其中序列之約80%、或至少約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%至約100%由選自
表 1之單一模體家族的兩個或更多個非重疊序列組成,使得產生「家族」序列,其中整個序列保持基本上非重複的。因此,在此等實施例中,XTEN序列包含多個單元之非重疊序列模體,該等非重疊序列模體為
表 1之序列的AD模體家族、或AE模體家族、或AF模體家族、或AG模體家族、或AM模體家族、或AQ模體家族、或BC家族、或BD家族。在其他情況下,XTEN包含來自
表 1之模體家族中之兩個或更多個的模體序列。
在一些實施例中,在本發明之組合物(例如融合蛋白)包含延伸重組多肽(XTEN)時,XTEN之特徵可在於:(i)包含至少12個胺基酸;(ii)XTEN序列之至少90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%的胺基酸殘基選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P);及(iii)其具有選自G、A、S、T、E及P之4至6種不同胺基酸。在一些實施例中,XTEN序列可由多種非重疊序列模體組成,其中該等序列模體(例如各自獨立地)選自
表 2 a- 2 b之序列模體。在一些實施例中,XTEN可具有40至3,000個胺基酸,或100至3,000個胺基酸。XTEN可(例如各自獨立地)具有至少(約)40個、至少(約)50個、至少(約)100個、至少(約)150個、至少(約)200個、至少(約)300個、至少(約)400個、至少(約)500個、至少(約)600個、至少(約)700個、至少(約)800個、至少(約)900個、至少(約)1,000個胺基酸、至少(約)1,500個胺基酸、至少(約)2,000個胺基酸、至少(約)2,500個胺基酸、至少(約)3,000個胺基酸或前述任一者之範圍之間。在一些實施例中,XTEN可與
表 2 a- 2 b中闡述之序列具有至少90%、至少91%、至少92%、至少93%、至少94%、至少95%、至少96%、至少97%、至少98%或至少99%或100%序列一致性。
表1:12個胺基酸之XTEN序列模體及模體家族
*表示個別模體序列,其在以各種排列在一起使用時產生「家族序列」
模體家族 * | SEQ ID NO: | 模體序列 |
AD | 182 | GESPGGSSGSES |
AD | 183 | GSEGSSGPGESS |
AD | 184 | GSSESGSSEGGP |
AD | 185 | GSGGEPSESGSS |
AE, AM | 186 | GSPAGSPTSTEE |
AE, AM, AQ | 187 | GSEPATSGSETP |
AE, AM, AQ | 188 | GTSESATPESGP |
AE, AM, AQ | 189 | GTSTEPSEGSAP |
AF, AM | 190 | GSTSESPSGTAP |
AF, AM | 191 | GTSTPESGSASP |
AF, AM | 192 | GTSPSGESSTAP |
AF, AM | 193 | GSTSSTAESPGP |
AG, AM | 194 | GTPGSGTASSSP |
AG, AM | 195 | GSSTPSGATGSP |
AG, AM | 196 | GSSPSASTGTGP |
AG, AM | 197 | GASPGTSSTGSP |
AQ | 198 | GEPAGSPTSTSE |
AQ | 199 | GTGEPSSTPASE |
AQ | 200 | GSGPSTESAPTE |
AQ | 201 | GSETPSGPSETA |
AQ | 202 | GPSETSTSEPGA |
AQ | 203 | GSPSEPTEGTSA |
BC | 881 | GSGASEPTSTEP |
BC | 882 | GSEPATSGTEPS |
BC | 883 | GTSEPSTSEPGA |
BC | 884 | GTSTEPSEPGSA |
BD | 885 | GSTAGSETSTEA |
BD | 886 | GSETATSGSETA |
BD | 887 | GTSESATSESGA |
BD | 888 | GTSTEASEGSAS |
在彼等實施例中,其中BPXTEN融合蛋白之XTEN組分具有小於100%之胺基酸,該等胺基酸由選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)之四至六種胺基酸組成,或具有小於100%之由表1之序列模體組成的序列,或與來自
表 2 a- 2 b之XTEN具有小於100%序列一致性,其他胺基酸殘基可選自14種天然L-胺基酸中的任何其他一種。其他胺基酸可散佈在整個XTEN序列中,可位於序列模體內或之間,或可集中在XTEN序列之一或多個短片段中。在其中BPXTEN之XTEN組分包含除甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)以外之胺基酸的此類情況下,較佳地,胺基酸不為疏水性殘基且不應實質上賦予XTEN組分之二級結構。因此,在前述之一較佳實施例中,除甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)以外,包含其他胺基酸之BPXTEN融合蛋白之XTEN組分將具有序列,該序列如藉由Chou-Fasman演算法所量測具有小於5%之促成α-螺旋及β-摺疊的殘基且如藉由GOR演算法所量測具有將具有至少90%的無規捲曲形成。
序列長度
在特定特徵中,本發明涵蓋包含具有延伸長度序列之XTEN多肽的BPXTEN組合物。本發明利用增加非重複非結構化多肽之長度增強XTEN之非結構化性質以及包含XTEN之融合蛋白的生物及藥物動力學特性的發現。如實例中更充分地描述,XTEN之長度的成比例增加,即使藉由單一家族序列模體(例如
表 1之四個AE模體)之固定重複次序產生,與較短XTEN長度相比可產生具有更高無規捲曲形成百分比(如藉由GOR演算法測定)的序列。另外,發現如實例中所描述,與具有較短序列長度之非結構化多肽搭配物的融合蛋白相比,增加非結構化多肽融合搭配物之長度可使得融合蛋白的終末半衰期不成比例地增加。
預期包括於本發明之BPXTEN中之XTEN的非限制性實例呈現於
表 2 a- 2 b中。因此,本發明提供BPXTEN組合物,其中融合蛋白之XTEN序列長度大於約100至約3000個胺基酸殘基,且在一些情況下大於400至約3000個胺基酸殘基,其中相比於不連接至XTEN之有效負載,XTEN賦予BPXTEN增強的藥物動力學特性。在一些情況下,本發明之BPXTEN組合物之XTEN序列的長度可為約100個、或約144個、或約288個、或約401個、或約500個、或約600個、或約700個、或約800個、或約900個、或約1000個、或約1500個、或約2000個、或約2500個或至多約3000個胺基酸殘基。在其他情況下,XTEN序列之長度可為約100至150個、約150至250個、約250至400個、401至約500個、約500至900個、約900至1500個、約1500至2000個或約2000至約3000個胺基酸殘基。在一個實施例中,BPXTEN可包含XTEN序列,其中該序列與選自
表 2 a- 2 b之XTEN相比呈現至少約80%序列一致性,或替代地81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性。在一些情況下,XTEN序列經設計以作為BPXTEN之N端組分用於最佳化表現。在前述之一個實施例中,XTEN序列與AE912或AM923之序列具有至少90%序列一致性。在前述之另一實施例中,XTEN具有實例14至17中所描述之N端殘基。
在其他情況下,BPXTEN融合蛋白可包含第一及第二XTEN序列,其中XTEN序列中之殘基的累積總計大於約400至約3000個胺基酸殘基。在前述之實施例中,BPXTEN融合蛋白可包含第一及第二XTEN序列,其中該等序列各自展現與選自
表 2 a- 2 b之至少第一或額外第二XTEN至少約80%序列一致性,或替代地81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性。BPXTEN組合物中使用超過一個XTEN之實例包括但不限於具有連接至至少一個BP之N端及C端兩者之XTEN的構築體。
如下文更充分地描述,本發明提供如下方法,其中藉由選擇XTEN之長度以賦予投與個體之融合蛋白的目標半衰期來設計BPXTEN。在一些情況下,可藉由選擇XTEN之長度以賦予投與個體之生物多肽的目標掩蔽效應來設計BPXTEN。一般而言,相比於較短XTEN,併入至BPXTEN組合物中之較長XTEN長度產生較長半衰期。然而,在另一實施例中,BPXTEN融合蛋白可經設計以包含具有較長序列長度之XTEN,其經選擇以在向個體皮下或肌肉內投與之後賦予較慢全身性吸收率。在此類情況下,與不連接至XTEN之BP的可比劑量相比,C
max降低,由此促成將BPXTEN保持在組合物之治療窗內的能力。因此,除本文所描述之其他物理/化學特性以外,XTEN賦予所投與之BPXTEN的儲庫型特性。
表2A:例示性XTEN多肽
表2B. 例示性XTEN多肽
淨電荷
XTEN 名稱 | SEQ ID NO: | 胺基酸序列 |
AE144 | 204 | GSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGSEPATSGSETPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAP |
AF144 | 205 | GTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGSTSESPSGTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSSTAESPGPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAP |
AE288 | 206 | GTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
AF504 | 207 | GASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSXPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSXPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSP |
AF540 | 208 | GSTSSTAESPGPGSTSSTAESPGPGSTSESPSGTAPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAP |
AD576 | 209 | GSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSGGEPSESGSSGSGGEPSESGSSGSGGEPSESGSSGSSESGSSEGGPGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSEGSSGPGESSGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSEGSSGPGESS |
AE576 | 210 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP |
AF576 | 211 | GSTSSTAESPGPGSTSSTAESPGPGSTSESPSGTAPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASP |
AD836 | 212 | GSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSGGEPSESGSSGSEGSSGPGESSGSSESGSSEGGPGSGGEPSESGSSGSEGSSGPGESSGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGSGGEPSESGSSGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSEGSSGPGESSGSEGSSGPGESSGSGGEPSESGSSGSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSEGSSGPGSSESGSSEGGPGSGGEPSESGSSGSEGSSGPGESSGSEGSSGPGESSGSEGSSGPGESSGSGGEPSESGSSGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGESPGGSSGSESGSGGEPSESGSSGSSESGSSEGGPGESPGGSSGSESGSGGEPSESGSSGESPGGSSGSESGSGGEPSESGSS |
AE864 | 213 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
AF864 | 214 | GSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGPXXXGASASGAPSTXXXXSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSP |
AG864 | 215 | GASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSP |
AM875 | 216 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP |
AE912 | 217 | MAEPAGSPTSTEEGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
AM923 | 218 | MAEPAGSPTSTEEGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP |
AM1296 | 219 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGPEPTGPAPSGGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASASGAPSTGGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGASPGTSSTGSPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGSSTPSGATGSPGASPGTSSTGSPGSSTPSGATGSPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAP |
BC 864 | 220 | GTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSEPATSGTEPSGTSEPSTSEPGAGSGASEPTSTEPGTSEPSTSEPGAGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSGASEPTSTEPGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSEPSTSEPGAGSGASEPTSTEPGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGTSEPSTSEPGAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSA |
BD864 | 221 | GSETATSGSETAGTSESATSESGAGSTAGSETSTEAGTSESATSESGAGSETATSGSETAGSETATSGSETAGTSTEASEGSASGTSTEASEGSASGTSESATSESGAGSETATSGSETAGTSTEASEGSASGSTAGSETSTEAGTSESATSESGAGTSESATSESGAGSETATSGSETAGTSESATSESGAGTSTEASEGSASGSETATSGSETAGSETATSGSETAGTSTEASEGSASGSTAGSETSTEAGTSESATSESGAGTSTEASEGSASGSETATSGSETAGSTAGSETSTEAGSTAGSETSTEAGSETATSGSETAGTSESATSESGAGTSESATSESGAGSETATSGSETAGTSESATSESGAGTSESATSESGAGSETATSGSETAGSETATSGSETAGTSTEASEGSASGSTAGSETSTEAGSETATSGSETAGTSESATSESGAGSTAGSETSTEAGSTAGSETSTEAGSTAGSETSTEAGTSTEASEGSASGSTAGSETSTEAGSTAGSETSTEAGTSTEASEGSASGSTAGSETSTEAGSETATSGSETAGTSTEASEGSASGTSESATSESGAGSETATSGSETAGTSESATSESGAGTSESATSESGAGSETATSGSETAGTSESATSESGAGSETATSGSETAGTSTEASEGSASGTSTEASEGSASGSTAGSETSTEAGSTAGSETSTEAGSETATSGSETAGTSESATSESGAGTSESATSESGAGSETATSGSETAGSETATSGSETAGSETATSGSETAGTSTEASEGSASGTSESATSESGAGSETATSGSETAGSETATSGSETAGTSESATSESGAGTSESATSESGAGSETATSGSETA |
SEQ ID NO. | 例示性用途 | 胺基酸序列 |
889(先前 8001) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGftabTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA |
890(先前 8002) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGPTESGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA |
891(先前 8003) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA |
892(先前 8004) | N端XTEN | ASSPAGSPTSTESGTSESATPESGPGTETEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
893(先前 8005) | N端XTEN | ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGESPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
894(先前 8006) | N端XTEN | ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGEEPATSGSTPEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
895(先前 8007) | N端XTEN | ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
896(先前 8008) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG |
897(先前 8009) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPG |
898(先前 8010) | N端XTEN | SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSTPAESGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESAS |
899(先前 8011) | C端XTEN | SAGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSTETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTATESPEGSAPGTSESATPESGPGTSTEPSEGSAPGTSAESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTESAS |
900(先前 8012) | N端XTEN | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPATSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESASPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
901(先前 8013) | N端XTEN | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSESATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
902(先前 8014) | N端XTEN(帶有His標籤) | SPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
903(先前 8015) | C端XTEN | PGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTESTPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGEPEA |
904(先前 8016) | C端XTEN | TPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSESATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESA |
905(先前 8017) | C端XTEN | GTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESASPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGP |
906(先前 8018 ) | C端XTEN | GSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSTETGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATS |
907(先前 8019 ) | C端XTEN | EGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESASPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESAT |
908(先前 8020) | N端 | ASSPAGSPTSTESGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSTPAESGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGGSAP |
在其他情況下,XTEN多肽可具有藉由併入具有淨電荷之胺基酸殘基及/或減少XTEN序列中之疏水性胺基酸之比例賦予的非結構化特徵。總體淨電荷及淨電荷密度可藉由調節XTEN序列中帶電荷胺基酸之含量來控制。在一些情況下,組合物之XTEN之淨電荷密度可高於+0.1或低於-0.1個電荷/殘基。在其他情況下,XTEN之淨電荷可為約0%、約1%、約2%、約3%、約4%、約5%、約6%、約7%、約8%、約9%、約10%、約11%、約12%、約13%、約14%、約15%、約16%、約17%、約18%、約19%或約20%或更多。
由於人類或動物中之大部分組織及表面具有淨負電荷,因此XTEN序列可經設計以具有淨負電荷以使含有XTEN之組合物與各種表面(諸如血管、健康組織或各種受體)之間的非特異性相互作用最小化。不受特定理論束縛,XTEN可由於XTEN多肽之個別胺基酸之間的靜電推斥而採用開放構形,該等個別胺基酸個別地攜帶高淨負電荷且分佈在整個XTEN多肽序列中。XTEN之延伸序列長度中之淨負電荷的此類分佈可產生非結構化構形,其轉而可引起流體動力學半徑之有效增加。因此,在一個實施例中,本發明提供XTEN,其中XTEN序列含有約8、10、15、20、25或甚至約30%麩胺酸。本發明之組合物之XTEN一般不具有帶正電荷之胺基酸或具有低含量之帶正電荷之胺基酸。在一些情況下,XTEN可具有小於約10%的帶正電荷之胺基酸殘基,或小於約7%、或小於約5%、或小於約2%的帶正電荷之胺基酸殘基。然而,本發明涵蓋如下構築體,其中可將有限數目之具有正電荷之胺基酸(諸如離胺酸)併入XTEN中以允許離胺酸之ε胺與肽上之反應性基團、連接子橋或藥物或小分子上之反應性基團之間的結合,以結合至XTEN主鏈。在前述內容中,可構築融合蛋白,其包含XTEN、生物活性蛋白、外加適用於治療疾病或病症之化學治療劑,其中併入至XTEN組分中之藥劑之分子的最大數目藉由離胺酸或具有併入至XTEN中之反應側鏈的其他胺基酸(例如半胱胺酸)的數目測定。
在一些情況下,XTEN序列可包含由諸如絲胺酸或甘胺酸之其他殘基分離的帶電荷殘基,其可引起較佳的表現或純化行為。基於淨電荷,本發明組合物之XTEN可具有1.0、1.5、2.0、2.5、3.0、3.5、4.0、4.5、5.0、5.5、6.0或甚至6.5之等電點(pI)。在較佳實施例中,XTEN將具有1.5與4.5之間的等電點。在此等實施例中,併入至本發明之BPXTEN融合蛋白組合物中之XTEN將在生理條件下攜帶淨負電荷,其可促成非結構化構形及XTEN組分與哺乳動物蛋白質及組織之結合減少。
因為疏水性胺基酸可賦予多肽結構,所以本發明提供XTEN中之疏水性胺基酸之含量通常將小於5%、或小於2%、或小於1%疏水性胺基酸含量。在一個實施例中,BPXTEN融合蛋白之XTEN組分中甲硫胺酸及色胺酸之胺基酸含量通常小於5%,或小於2%,且最佳小於1%。在另一實施例中,XTEN將具有一序列,該序列具有小於10%帶正電荷之胺基酸殘基,或小於約7%、或小於約5%、或小於約2%帶正電荷之胺基酸殘基,甲硫胺酸及色胺酸殘基之總和將小於2%,且天冬醯胺及麩醯胺酸殘基之總和將小於總XTEN序列之10%。
低免疫原性
在另一態樣中,本發明提供XTEN序列具有較低程度之免疫原性或基本上為非免疫原性的組合物。若干因素可促成XTEN之低免疫原性,例如非重複序列、非結構化構形、高程度之溶解度、低程度或缺乏自體聚集、低程度或缺乏序列內之蛋白水解位點,及低程度或缺乏XTEN序列中之構形抗原決定基。
構形抗原決定基由蛋白質表面之區域形成,該表面由蛋白質抗原之多個非連續胺基酸序列構成。蛋白質之精確摺疊使此等序列帶入定義明確的穩定空間組態或抗原決定基,可藉由宿主體液免疫系統將其識別為「外來」,使得產生針對蛋白質之抗體或觸發細胞介導之免疫反應。在後一情況中,個體對蛋白質之免疫反應很大程度上受T細胞抗原決定基識別影響,該T細胞抗原決定基識別為個體之HLA-DR同種異型的肽結合特異性的功能。MHC II類肽錯合物藉由T細胞表面上之同源T細胞受體與某些其他共受體(諸如CD4分子)之交叉結合的接合可在T細胞內誘導活化狀態。活化引起細胞介素釋放,進一步活化諸如B細胞之其他淋巴球以產生抗體或活化T殺手細胞作為完整細胞免疫反應。
肽結合給定MHC II類分子在APC(抗原呈現細胞)之表面上呈現的能力視多種因素而定;最值得注意的為其主要序列。在一個實施例中,可藉由設計抵抗在抗原呈現細胞中之抗原加工的XTEN序列及/或選擇不能很好地結合MHC受體之序列來達成較低程度之免疫原性。本發明提供具有基本上非重複XTEN多肽之BPXTEN融合蛋白,其經設計以減少與MHC II受體之結合以及避免形成針對T細胞受體或抗體結合之抗原決定基,從而產生較低程度之免疫原性。免疫原性之避免在某種程度上為XTEN序列之構形可撓性之直接結果;例如由於胺基酸殘基之選擇及次序而缺乏二級結構。舉例而言,備受關注的係在水溶液中或在可產生構形抗原決定基之生理條件下具有適應緊密摺疊之構形的低趨勢的序列。使用習知治療實踐及給藥投與包含XTEN之融合蛋白通常不會導致形成針對XTEN序列的中和抗體,且亦可降低BPXTEN組合物中BP融合搭配物之免疫原性。
在一個實施例中,本發明融合蛋白中使用之XTEN序列可基本上不含由人類T細胞識別之抗原決定基。先前已揭示出於產生較少免疫原性蛋白質之目的之此類抗原決定基的消除;參見例如以引用的方式併入本文中之WO 98/52976、WO 02/079232及WO 00/3317。已描述人類T細胞抗原決定基之分析(Stickler, M.,等人 (2003)
J Immunol Methods, 281: 95-108)。備受關注的係可在不產生T細胞抗原決定基或非人類序列下進行寡聚的肽序列。此可以藉由測試此等序列的直接重複來檢測T細胞抗原決定基的存在以及6至15聚體的發生,且特別係非人類的9聚體序列的發生,且隨後改變XTEN序列的設計以消除或破壞抗原決定基序列。在一些情況下,XTEN序列藉由經預測以結合MHC受體之XTEN的抗原決定基的數目的限制而基本上為非免疫原性的。隨著能夠結合至MHC受體之抗原決定基的數目減少,T細胞活化之潛力以及T細胞輔助功能亦隨之減少,B細胞活化或上調減少,及抗體產生減少。較低程度之所預測的T細胞抗原決定基可藉由抗原決定基預測演算法,諸如TEPITOPE(Sturniolo, T.,等人 (1999) Nat Biotechnol, 17: 555-61)來確定。蛋白質內指定肽框架之TEPITOPE評分為彼肽框架與多個最常見人類MHC對偶基因之結合的K
d(解離常數、親和力、解離速率)之對數,如Sturniolo, T.等人 (1999)
Nature Biotechnology17:555)中所揭示。評分範圍至少為20個對數,從約10到約-10(對應於10e
10K
d至10e
- 10K
d的結合約束),且可藉由避免疏水性胺基酸來降低,該等胺基酸可以在MHC上的肽顯示期間用作錨定殘基,諸如M、I、L、V、F。在一些實施例中,併入至BPXTEN中之XTEN組分在TEPITOPE評分下不具有所預測的T細胞抗原決定基,該TEPITOPE評分為約-5或更大、或-6或更大、或-7或更大、或-8或更大、或TEPITOPE評分為-9或更大。如本文所用,「-9或更大」之評分將涵蓋10至-9(包括端點)之TEPITOPE得分,但將不涵蓋-10之得分,因為-10小於-9。
在另一實施例中,本發明XTEN序列(包括併入至本發明BPXTEN融合蛋白中之彼等XTEN序列)可藉由限制來自XTEN之序列的已知蛋白水解位點,減少XTEN至可結合至MHC II受體之小肽中的加工而呈現基本上非免疫原性。在另一實施例中,XTEN序列可藉由使用基本上不含二級結構之序列而呈現為基本上非免疫原性的,該序列由於結構之高熵而賦予針對多種蛋白酶之抗性。因此,減少之TEPITOPE評分及自XTEN消除已知蛋白水解位點可使XTEN組合物(包括BPXTEN融合蛋白組合物之XTEN)基本上不能結合於哺乳動物受體,包括免疫系統之彼等受體。在一個實施例中,BPXTEN融合蛋白之XTEN可具有>100 nM K
d的與哺乳動物受體之結合,或大於500 nM K
d,或大於1 µM K
d的與哺乳動物細胞表面或循環多肽受體之結合。
另外,XTEN之非重複序列及相應抗原決定基之缺乏可限制B細胞結合至XTEN或由XTEN活化的能力。重複序列經識別且可甚至與少數B細胞形成多價接觸,且由於多個T細胞非依賴性受體之交聯,可刺激B細胞增殖及抗體產生。相比之下,雖然XTEN可在其延伸序列上與許多不同B細胞接觸,但由於序列缺乏重複性,各個別B細胞可僅與個別XTEN進行一次或少數接觸。因此,XTEN通常可具有低得多的刺激B細胞增殖的趨勢,且因此具有免疫反應。在一個實施例中,相比於未融合之對應BP,BPXTEN可具有降低之免疫原性。在一個實施例中,向哺乳動物投與至多三個非經腸劑量之BPXTEN可產生血清稀釋度為1:100而非稀釋度為1:1000之可偵測的抗BPXTEN IgG。在另一實施例中,向哺乳動物投與至多三個非經腸劑量之BPXTEN可產生血清稀釋度為1:100而非稀釋度為1:1000之可偵測的抗BP IgG。在另一實施例中,向哺乳動物投與至多三個非經腸劑量之BPXTEN可產生血清稀釋度為1:100而非稀釋度為1:1000之可偵測的抗XTEN IgG。在前述實施例中,哺乳動物可為小鼠、大鼠、兔或食蟹獼猴。
相對於具有高度重複性之序列,具有非重複序列之XTEN的額外特徵可為非重複XTEN與抗體形成較弱接觸。抗體係多價分子。舉例而言,IgG具有兩個相同結合位點且IgMs含有10個相同結合位點。因此,針對重複序列之抗體可以與此類具有高親合力之重複序列形成多價接觸,其可以影響此類重複序列之效能及/或消除。相比之下,針對非重複XTEN之抗體可產生單價相互作用,導致免疫清除的可能性降低,使得BPXTEN組合物可在循環中保持增加之時間段。
增加之流體動力學半徑
在另一態樣中,本發明提供XTEN,其中XTEN多肽可具有高流體動力學半徑,該高流體動力學半徑賦予併入XTEN之BPXTEN融合蛋白的對應增加之表觀分子量。相比於不連接至XTEN之BP,XTEN連接至BP序列可產生可具有增加之流體動力學半徑、增加之表觀分子量及增加之表觀分子量因子的BPXTEN組合物。舉例而言,在其中需要延長半衰期之治療應用中,組合物(其中具有高流體動力學半徑之XTEN併入至包含一或多種BP之融合蛋白中)可有效地擴大超過約3-5 nm之腎小球孔徑(對應於約70 kDA之表觀分子量)的組合物的流體動力學半徑(Caliceti. 2003. Pharmacokinetic and biodistribution properties of poly(ethylene glycol)-protein conjugates. Adv Drug Deliv Rev 55:1261-1277),使得循環蛋白質之腎清除率降低。蛋白質之流體動力學半徑係藉由其分子量以及其結構(包括形狀及緊密性)來測定。不受特定理論束縛,XTEN可由於肽之個別電荷之間的靜電推斥或序列中特定胺基酸賦予的固有可撓性而採用開放構形,該等胺基酸缺乏賦予二級結構的潛力。與具有二級及/或三級結構的具有可比序列長度及/或分子量的多肽(諸如典型的球狀蛋白)相比,XTEN多肽的開放、延伸及非結構化構形可具有更大的成比例流體動力學半徑。測定流體動力學半徑之方法為此項技術中熟知,諸如藉由使用尺寸排阻層析法(SEC),如美國專利第6,406,632號及第7,294,513號中所描述。增加XTEN的長度會導致流體動力學半徑、表觀分子量及表觀分子量因子的參數成比例增加,從而允許將BPXTEN調適為表觀分子量或流體動力學半徑之所需特徵性截止值。因此,在某些實施例中,BPXTEN融合蛋白可經組態具有XTEN,使得融合蛋白可具有至少約5 nm、或至少約8 nm、或至少約10 nm、或12 nm、或至少約15 nm之流體動力學半徑。在前述實施例中,XTEN在BPXTEN融合蛋白中賦予的大流體動力學半徑可導致所得融合蛋白之腎清除率降低,導致終末半衰期相應增加、平均滯留時間增加及/或腎清除率降低。
在另一實施例中,所選擇長度及序列之XTEN可選擇性地併入至BPXTEN中以產生在生理條件下將具有至少約100 kDa、至少約150 kDa、或至少約300 kDa、或至少約400 kDa、或至少約500 kDA、或至少約600 kDa、或至少約700 kDA、或至少約800 kDa、或至少約900 kDa、或至少約1000 kDa、或至少約1200 kDa、或至少約1500 kDa、或至少約1800 kDa、或至少約2000 kDa、或至少約2300 kDa或更多之表觀分子量的融合蛋白。在另一實施例中,所選擇長度及序列之XTEN可選擇性地連接至BP以產生在生理條件下BPXTEN融合蛋白具有至少三個、或者至少四個、或者至少五個、或者至少六個、或者至少八個、或者至少10個、或者至少15個、或至少20個表觀分子量因子或更多之表觀分子量因子。在另一實施例中,在生理條件下,相對於融合蛋白之實際分子量,BPXTEN融合蛋白具有約4至約20、或為約6至約15、或為約8至約12、或為約9至約10的表觀分子量因子。
BPXTEN融合蛋白組合物之生物活性蛋白
本發明部分地係關於包含生物活性蛋白質及XTEN之融合蛋白組合物及其用於治療個體之疾病、病症或病況的用途。
在一個態樣中,本發明提供至少一種共價連接至包含一或多個延伸重組多肽(「XTEN」)之融合蛋白的第一生物活性蛋白(下文中稱為「BP」),產生XTEN融合蛋白組合物(下文中稱為「BPXTEN」)。如下文更充分地描述,融合蛋白可視情況包括間隔子序列,該等間隔子序列可進一步包含裂解序列以在受到蛋白酶作用時自融合蛋白釋放BP。
如本文所用,術語「BPXTEN」意欲涵蓋包含一或兩個有效負載區之融合多肽,該等有效負載區各自包含介導一或多個生物或治療活性之生物活性蛋白及至少一個包含至少一個XTEN多肽之其他區。
本發明組合物之BP,特定言之揭示於表6中之彼等BP以及其對應核酸及胺基酸序列在此項技術中已熟知,且描述及序列可在公共資料庫中獲得,該等公共資料庫諸如化學文摘服務資料庫(例如CAS登記)、GenBank、通用蛋白質資源(UniProt)及訂閱提供之資料庫,諸如GenSeq(例如Derwent)。聚核苷酸序列可為編碼給定BP的野生型聚核苷酸序列(例如,全長或成熟),或在一些情況下,該序列可為野生型聚核苷酸序列的變異體(例如,編碼野生型生物活性蛋白的聚核苷酸),其中聚核苷酸的DNA序列已經最佳化,例如以用於在特定物種中表現;或編碼野生型蛋白質之變異體的聚核苷酸,諸如定點突變體或對偶基因變異體。本領域技術人員完全有能力使用野生型或共識cDNA序列或BP的密碼子最佳化變異體,使用此項技術中已知之方法及/或結合本文提供的指導及方法,創建本發明所涵蓋的BPXTEN構築體,且在實例中更充分地描述。
用於包括在本發明之BPXTEN中的BP可包括任何具有生物學、治療性、預防性或診斷相關或功能的蛋白質,或適用於在向個體投與時介導生物活性或預防或改善疾病、病症或病況。備受關注的係尋求增加藥物動力學參數、增加溶解度、增加穩定性或某種其他增強之醫藥特性的BP,或增加終末半衰期之彼等BP將改良療效、安全性或引起降低給藥頻率及/或改良患者順應性。因此,考慮到各種目標製備BPXTEN融合蛋白組合物,包括例如相較於不連接至XTEN之BP,藉由增加活體內暴露或當向個體投與時增加將BPXTEN保持在治療窗內之時長來改良生物活性化合物之治療功效。
本發明之BP可為天然的全長蛋白,或可為保留天然蛋白之生物活性之至少一部分的生物活性蛋白之片段或序列變異體。
在一個實施例中,併入至本發明組合物中之BP可為具有與自然界中發現之蛋白質對應之序列的重組多肽。在另一實施例中,BP可為保留天然BP之生物活性之至少一部分的天然序列之序列變異體、片段、同源物及模擬物。在非限制性實例中,BP可為展現出與選自表6之蛋白質序列至少約80%序列一致性,或替代地81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的序列。在一個實施例中,BPXTEN融合蛋白可包含連接至XTEN之單一BP分子(如下文更充分地描述)。在另一實施例中,BPXTEN可包含第一BP及相同BP之第二分子,產生包含連接至一或多個XTEN之兩個BP(例如兩個IL-1ra分子或兩個IL-10分子)的融合蛋白。生物活性蛋白(包括作為治療劑之彼等)通常為展現短儲存期限之不穩定分子,尤其當在水溶液中調配時。另外,多種生物活性肽及蛋白質溶解度有限,或在重組產生期間變得聚集,需要複雜的溶解及再摺疊程序。各種化學聚合物可連接至此類蛋白質以改變其特性。備受關注的係具有可撓性構形且在水溶液中充分水合之親水性聚合物。經常使用之聚合物為聚乙二醇(PEG)。此等聚合物傾向於具有相對於其分子量之較大流體動力學半徑(Kubetzko, S.,等人 (2005) Mol Pharmacol, 68: 1439-54),且可產生增強之藥物動力學特性。視連接點而定,聚合物傾向於與其連接之蛋白質具有有限相互作用,使得聚合物修飾之蛋白質保留其相關功能。然而,聚合物與蛋白質之化學結合需要複雜的多步驟過程。通常,蛋白質組分需要在化學結合步驟之前產生及純化。另外,結合步驟可引起需要分離之異質產品混合物的形成,引起顯著的產品損失。或者,此類混合物可用作最終醫藥產品,但難以標準化。一些實例為當前市售用作混合物之聚乙二醇化干擾素-α產品(Wang, B. L.,等人 (1998) J Submicrosc Cytol Pathol, 30: 503-9;Dhalluin, C.,等人 (2005) Bioconjug Chem, 16: 504-17)。此類混合物難以可再現地製造及表徵,因為其含有具有降低的或無治療活性之異構物。
一般而言,當用於活體內時或當用於活體外分析中時,BP將對給定目標或另一所需生物特徵展現結合特異性。舉例而言,BP可為促效劑、受體、配位體、拮抗劑、酶或激素。備受關注的係所使用或已知適用於疾病或病症的BP,其中天然BP具有相對短的終末半衰期且其藥物動力學參數的增強(其視情況可藉由裂解間隔子序列自融合蛋白質釋放)將允許不太頻繁的給藥或增強的藥理學效應。亦關注在最小有效劑量或血液濃度(C
min)與最大耐受劑量或血液濃度(C
max)之間具有窄治療窗之BP。在此類情況下,BP與包含選擇XTEN序列之融合蛋白的連接可引起此等特性之改良,使得相比於不連接至XTEN之BP,其更適用作治療劑或預防劑。
BP可為細胞介素。本發明組合物所涵蓋之細胞介素可在治療各種治療性或疾病類別中具有效用,包括(但不限於)癌症、類風濕性關節炎、多發性硬化症、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症、精神分裂症
、病毒感染(例如,慢性C型肝炎、AIDS)、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症。細胞介素可尤其適用於治療發炎性病況及自體免疫性病況。
BP可為一或多種細胞介素。細胞介素係指可影響細胞行為之由細胞釋放的蛋白質(例如趨化介素、干擾素、淋巴介質、介白素及腫瘤壞死因子)。細胞介素可由廣泛範圍之細胞產生,包括(但不限於)免疫細胞,諸如巨噬細胞、B淋巴球、T淋巴球、微神經膠質細胞及肥大細胞,以及內皮細胞、纖維母細胞及各種基質細胞。給定細胞介素可由超過一種類型之細胞產生。細胞介素可涉及產生全身或局部免疫調節效應。
某些細胞介素可充當促炎性細胞介素。促炎性細胞介素係指參與誘導或放大發炎反應之細胞介素。促炎性細胞介素可與免疫系統之各種細胞(諸如嗜中性球及白血球)起作用以產生免疫反應。某些細胞介素可充當抗炎細胞介素。抗炎細胞介素係指涉及減少發炎性反應之細胞介素。在一些情況下,抗炎細胞介素可調節促炎性細胞介素反應。一些細胞介素可充當促炎性細胞介素及抗炎細胞介素兩者。
可藉由本發明之系統及組合物調節之細胞介素之實例包括但不限於淋巴介質、單核因子及除了人類生長激素之外的傳統多肽激素。細胞介素尤其包括副甲狀腺激素;甲狀腺素;胰島素;胰島素原;鬆弛素;鬆弛素原;糖蛋白激素,諸如促卵泡激素(FSH)、促甲狀腺激素(TSH)及促黃體生成激素(LH);肝生長因子;纖維母細胞生長因子;促乳素;胎盤催乳激素;腫瘤壞死因子-α;苗勒氏管抑制物質(mullerian-inhibiting substance);小鼠促性腺激素相關肽;抑制素;活化素;血管內皮生長因子;整合素;血小板生成素(TPO);神經生長因子,諸如NGF-β;血小板生長因子;轉型生長因子(TGF),諸如TGF-α、TGF-β、TGF-β1、TGF-β2及TGF-β3;類胰島素生長因子-I及類胰島素生長因子-II;紅血球生成素(EPO);Flt-3L;幹細胞因子(SCF);骨性誘導因子;干擾素(IFN),諸如IFN-α、IFN-β及IFN-γ;群落刺激因子(CSF),諸如巨噬細胞-CSF(M-CSF);顆粒球-巨噬細胞-CSF(GM-CSF);顆粒球-CSF(G-CSF);巨噬細胞刺激因子(MSP);介白素(IL),諸如IL-1、IL-1a、IL-1b、IL-1RA、IL-18、IL-2、IL-3、IL-4、IL-5、IL-6、IL-7、IL-8、IL-9、IL-10、IL-11、IL-12、IL-12b、IL-13、IL-14、IL-15、IL-16、IL-17、IL-20;腫瘤壞死因子,諸如CD154、LT-β、TNF-α、TNF-β、4-1BBL、APRIL、CD70、CD153、CD178、GITRL、LIGHT、OX40L、TALL-1、TRAIL、TWEAK、TRANCE;及其他多肽因子,包括LIF、抑瘤素M(OSM)及kit配位體(kit ligand,KL)。細胞介素受體係指結合細胞介素之受體蛋白。細胞介素受體可為膜結合的及可溶的。
目標聚核苷酸可編碼細胞介素。細胞介素之非限制性實例包括4-1BBL、活化素βA、活化素βB、活化素βC、活化素βE、青蒿素(ARTN)、BAFF/BLyS/TNFSF138、BMP10、BMP15、BMP2、BMP3、BMP4、BMP5、BMP6、BMP7、BMP8a、BMP8b、骨形態生成蛋白1(BMP1)、CCL1/TCA3、CCL11、CCL12/MCP-5、CCL13/MCP-4、CCL14、CCL15、CCL16、CCL17/TARC、CCL18、CCL19、CCL2/MCP-1、CCL20、CCL21、CCL22/MDC、CCL23、CCL24、CCL25、CCL26、CCL27、CCL28、CCL3、CCL3L3、CCL4、CCL4L1/LAG-1、CCL5、CCL6、CCL7、CCL8、CCL9、CD153/CD30L/TNFSF8、CD40L/CD154/TNFSF5、CD40LG、CD70、CD70/CD27L/TNFSF7、CLCF1、c-MPL/CD110/ TPOR、CNTF、CX3CL1、CXCL1、CXCL10、CXCL11、CXCL12、CXCL13、CXCL14、CXCL15、CXCL16、CXCL17、CXCL2/MIP-2、CXCL3、CXCL4、CXCL5、CXCL6、CXCL7/Ppbp、CXCL9、EDA-A1、FAM19A1、FAM19A2、FAM19A3、FAM19A4、FAM19A5、Fas配位體/FASLG/CD95L/CD178、GDF10、GDF11、GDF15、GDF2、GDF3、GDF4、GDF5、GDF6、GDF7、GDF8、GDF9、膠質細胞株系源性神經營養因子(GDNF)、生長分化因子1(GDF1)、IFNA1、IFNA10、IFNA13、IFNA14、IFNA2、IFNA4、IFNA5/IFNaG、IFNA7、IFNA8、IFNB1、IFNE、IFNG、IFNZ、IFNω/IFNW1、IL11、IL18、IL18BP、IL1A、IL1B、IL1F10、IL1F3/IL1RA、IL1F5、IL1F6、IL1F7、IL1F8、IL1F9、IL1RL2、IL31、IL33、IL6、IL8/CXCL8、抑制素-A、抑制素-B、瘦素、LIF、LTA/TNFB/TNFSF1、LTB/TNFC、神經營養素(NRTN)、OSM、OX-40L/TNFSF4/CD252、珀瑟芬(persephin,PSPN)、RANKL/OPGL/TNFSF11(CD254)、TL1A/TNFSF15、TNFA、TNF-α/TNFA、TNFSF10/TRAIL/APO-2L(CD253)、TNFSF12、TNFSF13、TNFSF14/LIGHT/CD258、XCL1及XCL2。在一些實施例中,目標基因編碼免疫檢查點抑制劑。此類免疫檢查點抑制劑之非限制性實例包括PD-1、CTLA-4、LAG3、TIM-3、A2AR、B7-H3、B7-H4、BTLA、IDO、KIR及VISTA。在一些實施例中,目標基因編碼T細胞受體(TCR)α、β、γ及/或δ鏈。
在一些情況下,細胞介素可為趨化介素。趨化介素可選自以下之群,其包括但不限於:ARMCX2、BCA-1/CXCL13、CCL11、CCL12/MCP-5、CCL13/MCP-4、CCL15/MIP-5/MIP-1δ、CCL16/HCC-4/NCC4、CCL17/TARC、CCL18/PARC/MIP-4、CCL19/MIP-3b、CCL2/MCP-1、CCL20/MIP-3α/MIP3A、CCL21/6Ckine、CCL22/MDC、CCL23/MIP 3、CCL24/伊紅趨素-2/MPIF-2、CCL25/TECK、CCL26/伊紅趨素-3、CCL27/CTACK、CCL28、CCL3/Mip1a、CCL4/MIP1B、CCL4L1/LAG-1、CCL5/RANTES、CCL6/C10、CCL8/MCP-2、CCL9、CML5、CXCL1、CXCL10/Crg-2、CXCL12/SDF-1β、CXCL14/BRAK、CXCL15/Lungkine、CXCL16/SR-PSOX、CXCL17、CXCL2/MIP-2、CXCL3/GROγ、CXCL4/PF4、CXCL5、CXCL6/GCP-2、CXCL9/MIG、FAM19A1、FAM19A2、FAM19A3、FAM19A4/TAFA4、FAM19A5、Fractalkine/CX3CL1、I-309/CCL1/TCA-3、IL-8/CXCL8、MCP-3/CCL7、NAP-2/PPBP/CXCL7、XCL2及Armo IL10。
表 3提供本發明之BPXTEN融合蛋白所涵蓋之此類BRP序列之非限制性清單。本發明BPXTEN組合物之代謝蛋白質可為展現出與選自
表 3之蛋白質序列至少約80%序列一致性,或替代地81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的蛋白質。
表3:用於結合的細胞介素
表A.例示性介白素-12(IL-12)或其片段之胺基酸序列
蛋白質名稱 (同義詞 ) | 序列 |
抗CD3 | 參見 美國專利第 5 , 885 , 573 號及第 6 , 491 , 916 號 |
IL-1ra,人類全長 | MEICRGLRSHLITLLLFLFHSETICRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE(SEQ ID NO: 152) |
IL-1ra,犬 | METCRCPLSYLISFLLFLPHSETACRLGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGSNTKLEEKLDVVPVEPHAVFLGIHGGKLCLACVKSGDETRLQLEAVNITDLSKNKDQDKRFTFILSDSGPTTSFESAACPGWFLCTALEADRPVSLTNRPEEAMMVTKFYFQKE(SEQ ID NO: 153) |
IL-1ra,兔 | MRPSRSTRRHLISLLLFLFHSETACRPSGKRPCRMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNAKLEERIDVVPLEPQLLFLGIQRGKLCLSCVKSGDKMKLHLEAVNITDLGKNKEQDKRFTFIRSNSGPTTTFESASCPGWFLCTALEADQPVSLTNTPDDSIVVTKFYFQED(SEQ ID NO: 154) |
IL-1ra,大鼠 | MEICRGPYSHLISLLLILLFRSESAGHIPAGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNTKLEEKIDMVPIDFRNVFLGIHGGKLCLSCVKSGDDTKLQLEEVNITDLNKNKEEDKRFTFIRSETGPTTSFESLACPGWFLCTTLEADHPVSLTNTPKEPCTVTKFYFQED(SEQ ID NO: 155) |
IL-1ra,小鼠 | MEICWGPYSHLISLLLILLFHSEAACRPSGKRPCKMQAFRIWDTNQKTFYLRNNQLIAGYLQGPNIKLEEKIDMVPIDLHSVFLGIHGGKLCLSCAKSGDDIKLQLEEVNITDLSKNKEEDKRFTFIRSEKGPTTSFESAACPGWFLCTTLEADRPVSLTNTPEEPLIVTKFYFQEDQ(SEQ ID NO: 156) |
阿那白滯素 | MRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDE(SEQ ID NO: 157) |
IL-10 | MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN(SEQ ID NO: 158) |
名稱 | SEQ ID NO. | 胺基酸序列 |
介白素 - 12 次單元 β ( IL- 12 p 40 ) | 5 | MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRS |
介白素 - 12 次單元 α ( IL- 12 p 35 ) | 6 | RVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA |
IL- 12 變異體 | 7 | MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGGGGSGGGGSGGGGSRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA |
表 A提供介白素-12序列(或其片段)之非限制性清單。本發明之本發明之BPXTEN組合物可含有胺基酸序列,其展現出與選自
表 A之蛋白質序列至少約80%序列一致性,或替代地81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性。
在一些實施例中,在本發明之組合物(諸如融合蛋白)包含細胞介素時,細胞介素可選自由以下組成之群:介白素、趨化介素、干擾素、腫瘤壞死因子、群落刺激因子或轉型生長因子β(TGF-β)超家族成員。在一些實施例中,細胞介素係可為選自由以下組成之群的介白素:IL1、IL2、IL3、IL4、IL5、IL6、IL7、IL8、IL9、IL10、IL11、IL12、IL13、IL14、IL15、IL16及IL17。在一些實施例中,細胞介素可具有與選自
表 3或
表 A之序列至少(約)80%、至少(約)81%、至少(約)82%、至少(約)83%、至少(約)84%、至少(約)85%、至少(約)86%、至少(約)87%、至少(約)88%、至少(約)89%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性。在一些實施例中,細胞介素可具有與選自
表 3之序列至少(約)80%、至少(約)81%、至少(約)82%、至少(約)83%、至少(約)84%、至少(約)85%、至少(約)86%、至少(約)87%、至少(約)88%、至少(約)89%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性。在一些實施例中,細胞介素可具有與選自
表 A之序列至少(約)80%、至少(約)81%、至少(約)82%、至少(約)83%、至少(約)84%、至少(約)85%、至少(約)86%、至少(約)87%、至少(約)88%、至少(約)89%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性。在一些實施例中,細胞介素可為IL-12或IL-12變異體。在一些實施例中,細胞介素可包含第一細胞介素片段(Cy1)及第二細胞介素片段(Cy2)。在一些實施例中,Cy1及Cy2中之一者可包含與介白素-12次單元β具有至少70%序列一致性之胺基酸序列。在一些實施例中,Cy1及Cy2中之另一者可包含與介白素-12次單元α具有至少(約)70%、至少(約)75%、至少(約)80%、至少(約)85%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性之胺基酸序列。在一些實施例中,第一細胞介素片段(Cy1)可包含與序列
SEQ ID NO. 5具有至少(約)70%、至少(約)75%、至少(約)80%、至少(約)85%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性之胺基酸序列。在一些實施例中,第二細胞介素片段(Cy2)可包含與序列
SEQ ID NO. 6具有至少(約)70%、至少(約)75%、至少(約)80%、至少(約)85%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性之胺基酸序列。在一些實施例中,細胞介素可包含位於第一細胞介素片段(Cy1)及第二細胞介素片段(Cy2)之間的連接子。在一些實施例中,細胞介素可為包含與
SEQ ID NO. 7具有至少(約)70%、至少(約)75%、至少(約)80%、至少(約)85%、至少(約)90%、至少(約)91%、至少(約)92%、至少(約)93%、至少(約)94%、至少(約)95%、至少(約)96%、至少(約)97%、至少(約)98%、至少(約)99%或100%序列一致性之胺基酸序列的IL-12變異體。連接子可為GS連接子(諸如GGGGS)
1(SEQ ID NO: 273)、(GGGGS)
2(SEQ ID NO: 273)、(GGGGS)
3(SEQ ID NO: 273)、(GGGGS)
4(SEQ ID NO: 273)、(GGGGS)
5(SEQ ID NO: 273)等)。
「IL-1ra」意謂人類IL-1受體拮抗劑蛋白質及其物種及序列變異體,包括序列變異體阿那白滯素(Kineret®),其具有成熟IL-1ra之生物活性之至少一部分。人類IL-1ra為152個胺基酸殘基之成熟醣蛋白。IL-1ra之抑制作用由其與I型IL-1受體之結合而產生。蛋白質之天然分子量為25 kDa,且分子顯示與IL-1α(19%)及IL-1ß(26%)之有限序列同源性。阿那白滯素為非醣化重組人類IL-1ra且藉由添加N端甲硫胺酸而不同於內源性人類IL-1ra。阿那白滯素之商業化版本以Kineret®出售。其以與天然IL-1ra及IL-1b相同親合力與IL-1受體結合,但並不導致受體活化(信號轉導),該效應歸因於IL-1ra上僅存在一個受體結合模體,而IL-1α及IL-1ß上存在兩個此類模體。阿那白滯素具有153個胺基酸且大小為17.3 kD,且報導半衰期為大致4至6小時。
IL-1產量增加已報導於具有各種病毒、細菌、真菌及寄生蟲感染;血管內凝血;高劑量IL-2療法;實體腫瘤;白血病;阿茲海默氏症;HIV-1感染;自體免疫疾病;外傷(手術);血液透析;缺血性疾病(心肌梗塞);非感染性肝炎;哮喘;UV輻射;閉合性顱腦損傷;胰臟炎;腹膜炎;移植物抗宿主病;移植排斥之患者;以及費勁運動之後的健康個體中。患有阿茲海默氏症之患者中IL-1b產量增加與IL 1在澱粉樣蛋白前驅蛋白釋放中之作用之間存在關聯。IL-1亦與疾病相關,該等疾病諸如2型糖尿病、肥胖症、高血糖、高胰島素血症、1型糖尿病、胰島素抗性、視網膜神經退化性過程、以胰島素抗性為特徵之疾病狀態及病況、急性心肌梗塞(AMI)、急性冠狀動脈症候群(ACS)、動脈粥樣硬化、慢性發炎性病症、類風濕性關節炎、退化性椎間盤疾病、類肉瘤病、克羅恩氏病(Crohn's disease)、潰瘍性結腸炎、妊娠期糖尿病、食慾亢進、飽腹感不足、代謝障礙、胰高血糖素瘤、氣道分泌病症、骨質疏鬆症、中樞神經系統疾病、再狹窄、神經退化性疾病、腎衰竭、充血性心力衰竭、腎病症候群、肝硬化、肺水腫、高血壓、需要減少食物攝入量的病症、腸激躁症候群、心肌梗塞、中風、手術後代謝變化、休眠心肌、糖尿病心肌病、尿鈉排泄不足、尿鉀濃度過高、與中毒性高血容量相關的病況或病症、多囊性卵巢症候群、呼吸窘迫、慢性皮膚潰瘍、腎病、左心室收縮功能障礙、胃腸道腹瀉、手術後傾倒症候群、腸激躁症候群、危重病多發性神經病(CIPN)、全身性發炎反應症候群(SIRS)、血脂異常、局部缺血後再灌注損傷及冠心病風險因素(CHDRF)症候群。本發明之含IL-1ra融合蛋白可在治療前述疾病及病症中之任一者中發現特定用途。IL-1ra已經選殖,如美國專利第5,075,222號及第6,858,409號中所描述。
在一些情況下,BP可為IL-10。IL-10可為有效的抗炎細胞介素,其抑制促炎性細胞介素及趨化介素之產生。IL-10為主要的TH2型細胞介素中之一者,其增加體液免疫反應且減少細胞介導之免疫反應。IL-10可適用於治療自體免疫性疾病及發炎性疾病,諸如類風濕性關節炎、多發性硬化症、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症、精神分裂症、過敏性哮喘、視網膜神經退化性過程及糖尿病。
在一些情況下,IL-10可經修飾以改良穩定性且減少質子遷移降解。修飾可為一或多個醯胺鍵取代。在一些情況下,IL-10主鏈內之一或多個醯胺鍵可經取代以實現上述效應。IL-10中之一或多個醯胺鍵(—CO—NH—)可經醯胺鍵的同電子排列體鍵取代,諸如—CH2NH—、—CH2S—、—CH2CH2-、—CH═CH-(順式及反式)、—COCH2-、—CH(OH)CH2—或—CH2SO—。此外,IL-10中之醯胺鍵亦可經減少之同電子排列體假肽鍵置換。參見Couder等人 (1993) Int. J. Peptide Protein Res. 41:181-184,其以全文引用之方式併入本文中。
一或多種酸性胺基酸,包括天冬胺酸、麩胺酸、高麩胺酸、酪胺酸、烷基、芳基、芳基烷基及2,4-二胺基丙二酸之雜芳基磺醯胺、鳥胺酸或離胺酸及經四唑取代之烷基胺基酸;及側鏈醯胺殘基,諸如天冬醯胺、麩醯胺酸及天冬醯胺或麩醯胺酸之烷基或芳族取代衍生物;以及含羥基胺基酸,包括絲胺酸、蘇胺酸、高絲胺酸、2,3-二胺基丙酸、以及絲胺酸或蘇胺酸之烷基或芳族取代衍生物。
IL-10中之一或多個疏水性胺基酸(諸如丙胺酸、白胺酸、異白胺酸、纈胺酸、正白胺酸、(S)-2-胺基丁酸、(S)-環己基丙胺酸或其他簡單α-胺基酸)可經胺基酸取代,該等胺基酸包括但不限於來自C1-C10碳之脂族側鏈,包括分支鏈、環狀及直鏈烷基、烯基或炔基取代。
在一些情況下,IL-10之一或多個疏水性胺基酸,諸如可經芳族取代之疏水性胺基酸的取代,包括苯丙胺酸、色胺酸、酪胺酸、磺基酪胺酸、聯苯丙胺酸、1-萘基丙胺酸、2-萘基丙胺酸、2-苯并噻吩基丙胺酸、3-苯并噻吩基丙胺酸、組胺酸、包括胺基、烷基胺基、二烷基胺基、氮雜、鹵化(氟、氯、溴或碘)或烷氧基(來自C1-C4)取代之以上所列的芳族胺基酸形式,其說明性實例有:2-、3-或4-胺基苯丙胺酸、2-、3-或4-氯苯丙胺酸、2-、3-或4-甲基苯丙胺酸、2-、3-或4-甲氧基苯丙胺酸、5-胺基-、5-氯-、5-甲基-或5-甲氧基色胺、2'-、3'-或4'-胺基-、2'-、3'-或4'-氯-、2、3或4-聯苯丙胺酸、2'-、3'-或4'-甲基-、2-、3-或4-聯苯丙胺酸及2-或3-吡啶丙胺酸。
IL-10中之一或多個疏水性胺基酸(諸如苯丙胺酸、色胺酸、酪胺酸、磺基酪胺酸、聯苯丙胺酸、1-萘基丙胺酸、2-萘基丙胺酸、2-苯并噻吩基丙胺酸、3-苯并噻吩基丙胺酸、組胺酸、包括胺基、烷基胺基、二烷基胺基、氮雜、鹵化(氟、氯、溴或碘)或烷氧基可取代之芳族胺基酸包括:2-、3-或4-胺基苯丙胺酸、2-、3-或4-氯苯丙胺酸、2-、3-或4-甲基苯丙胺酸、2-、3-或4-甲氧基苯丙胺酸、5-胺基-、5-氯-、5-甲基-或5-甲氧基色胺、2'-、3'-或4'-胺基-、2'-、3'-或4'-氯-、2、3或4-聯苯丙胺酸、2'-、3'-或4'-甲基-、2-、3-或4-聯苯丙胺酸及2-或3-吡啶丙胺酸。
包含鹼性側鏈之胺基酸,包括精胺酸、離胺酸、組胺酸、鳥胺酸、2,3-二胺基丙酸、高精胺酸,包括先前胺基酸之烷基、烯基或芳基取代衍生物,可經取代。實例為N-ε-異丙基-離胺酸、3-(4-四氫吡啶基)-甘胺酸、3-(4-四氫吡啶基)-丙胺酸、N,N-γ,γ'-二乙基-高精胺酸、α-甲基-精胺酸、α-甲基-2,3-二胺基丙酸、α-甲基-組胺酸及α-甲基-鳥胺酸,其中烷基佔據α-碳的前R位置。經修飾之IL-10可包含由烷基、芳族、雜芳族、鳥胺酸或2,3-二胺基丙酸、羧酸或許多熟知活化衍生物中之任一者的任何組合形成之醯胺,該等衍生物諸如酸氯化物、活性酯、活性氮雜內酯及相關衍生物、離胺酸及鳥胺酸。
在一些情況下,IL-10可包含一或多種天然存在之L-胺基酸、合成之L-胺基酸及/或胺基酸之D-鏡像異構物。IL-10多肽可包含以下胺基酸中之一或多者:ω-胺基癸酸、ω-胺基十四酸、環己基丙胺酸、α,γ-二胺基丁酸、α,β-二胺基丙酸、δ-胺基戊酸、三級丁基丙胺酸、三級丁基甘胺酸、N-甲基異白胺酸、苯基甘胺酸、環己基丙胺酸、正白胺酸、萘基丙胺酸、鳥胺酸、瓜胺酸、4-氯苯丙胺酸、2-氟苯丙胺酸、吡啶丙胺酸、3-苯并噻吩丙胺酸、羥脯胺酸、β-丙胺酸、鄰胺基苯甲酸、間胺基苯甲酸、對胺基苯甲酸、間胺基甲基苯甲酸、2,3-二胺基丙酸、α-胺基異丁酸、N-甲基甘胺酸(肌胺酸)、3-氟苯丙胺酸、4-氟苯丙胺酸、青黴胺、1,2,3,4-四氫異喹啉-3-甲酸、β-2-噻吩丙胺酸、甲硫胺酸亞碸、高精胺酸、N-乙醯基離胺酸、2,4-二胺基丁酸、rho-胺基苯丙胺酸、N-甲基纈胺酸、高半胱胺酸、高絲胺酸、ε-胺基己酸、ω-胺基己酸、ω-胺基庚酸、ω-胺基辛酸及2,3-二胺基丁酸。
IL-10可包含半胱胺酸殘基或半胱胺酸,其可經由二硫鍵充當另一肽之連接子或提供IL-10多肽之環化。引入半胱胺酸或半胱胺酸類似物之方法為此項技術中已知;參見例如美國專利第8,067,532號。IL-10多肽可環化。其他環化方式包括引入肟連接子或羊毛硫胺酸連接子;參見例如美國專利第8,044,175號。可使用及/或引入可形成環化鍵之胺基酸(或非胺基酸部分)之任何組合。環化鍵可以由胺基酸(或胺基酸及—(CH2)n-CO—或—(CH2)n-C6H4—CO—)與允許引入橋的官能基的任何組合生成。一些實例為二硫化物、二硫化物模擬物,諸如—(CH2)n-脲橋、硫縮醛、硫醚橋(胱硫醚或羊毛硫胺酸)及含有酯及醚之橋。
IL-10可經N-烷基、芳基或主鏈交聯取代以構築內醯胺及其他環狀結構、C端羥甲基衍生物、o-修飾衍生物、N端修改衍生物,包括經取代之醯胺,諸如烷基醯胺及醯肼。在一些情況下,IL-10多肽為逆轉錄類似物。
IL-10可為一種IL-10,其可為天然蛋白質、肽片段IL-10或經修飾之肽,其具有天然IL-10之至少一部分生物活性。IL-10可經修飾以改良細胞內攝取。一個此類修飾可為蛋白質轉導域之連接。蛋白質轉導域可連接至IL-10之C端。或者,蛋白質轉導域可連接至IL-10之N端。蛋白質轉導域可經由共價鍵連接至IL-10。蛋白質轉導域可選自
表 9中所列之序列中之任一者。
表9. 例示性蛋白轉導域
BPXTEN結構組態及屬性
胺基酸序列 |
YGRKKRRQRRR(SEQ ID NO: 8) |
RRQRRTSKLMKR(SEQ ID NO: 9) |
GWTLNSAGYLLGKINLKALAALAKKIL(SEQ ID NO: 10) |
KALAWEAKLAKALAKALAKHLAKALAKALKCEA(SEQ ID NO: 11) |
RQIKIWFQNRRMKWKK(SEQ ID NO: 12) |
YGRKKRRQRRR(SEQ ID NO: 13) |
RKKRRQRRR(SEQ ID NO: 14) |
YGRKKRRQRRR(SEQ ID NO: 15) |
RKKRRQRR(SEQ ID NO: 16) |
YARAAARQARA(SEQ ID NO: 17) |
THRLPRRRRRR(SEQ ID NO: 18) |
GGRRARRRRRR(SEQ ID NO: 19) |
本發明組合物之BP不限於天然、全長多肽,且亦包括重組型式以及生物學及/或藥理學活性變異體或其片段。舉例而言,應瞭解,在GP中可進行各種胺基酸取代以在不背離本發明之精神的情況下產生關於BP之生物活性或藥理學特性的變異體。多肽序列中胺基酸之保守取代之實例展示於
表 4中。然而,在與本文所揭示之特定序列相比BP之序列一致性小於100%的BPXTEN的實施例中,本發明涵蓋其他19種天然L-胺基酸中之任一者取代給定BP之給定胺基酸殘基,其可在BP之序列內的任何位置處,包括相鄰胺基酸殘基。若任何一個取代引起生物活性發生不合需要的變化,則可採用替代性胺基酸中之一者且藉由本文所描述之方法或使用例如於美國專利第5,364,934號中所闡述保守及非保守突變的任何技術及指南(其內容以全文引用之方式併入),或使用熟習此項技術者通常已知之方法評估構築體。另外,變異體亦可包括例如多肽,其中在BP之全長天然胺基酸序列的N端或C端添加或刪除一或多個胺基酸殘基,其保留了天然肽的至少一部分生物活性。
表4:例示性保守胺基酸取代
BPXTEN融合蛋白組態
初始殘基 | 例示性取代 |
Ala(A) | val ; leu ; ile |
Arg(R) | lys ; gin ; asn |
Asn(N) | gin ; his ; Iys ; arg |
Asp(D) | glu |
Cys(C) | ser |
Gln(Q) | asn |
Glu(E) | asp |
Gly(G) | pro |
His(H) | asn : gin: Iys : arg |
xIle(I) | leu ; val ; met ; ala ; phe :正白胺酸 |
Leu(L) | 正白胺酸: ile : val ; met ; ala : phe |
Lys(K) | arg : gin : asn |
Met(M) | leu ; phe ; ile |
Phe(F) | leu : val : ile ; ala |
Pro(P) | gly |
Ser(S) | thr |
Thr(T) | ser |
Trp(W) | tyr |
Tyr(Y) | trp : phe : thr : ser |
Val(V) | ile ; leu ; met ; phe ; ala ;正白胺酸 |
本發明提供包含連接至一或多種XTEN多肽之BP的BPXTEN融合蛋白組合物,該一或多個XTEN多肽適用於預防、治療、介導或改善與葡萄糖穩態、胰島素抗性或肥胖症相關之疾病、病症或病況。在一些情況下,BPXTEN為具有連接至一或多個XTEN多肽之BP的單體融合蛋白。在其他情況下,BPXTEN組合物可包括連接至一或多個XTEN多肽之兩個BP分子。本發明涵蓋BPXTEN,其包含(但不限於)選自
表 3或
表 A(或其片段或序列變異體)之BP及選自
表 2 a- 2 b之XTEN或其序列變異體。在一些情況下,對應BP之生物活性的至少一部分藉由完整的BPXTEN保持。在其他情況下,BP組分藉由併入間隔子序列內之可選裂解序列裂解至BPXTEN中而變得具有生物活性或在其自XTEN釋放後具有活性增加,下文更充分描述。
在一些實施例中,BPXTEN融合蛋白組合物包含(a)XTEN(諸如本文所揭示之XTEN)及(b)連接至XTEN之細胞介素。
在BPXTEN組合物之一個實施例中,本發明提供一種式I之融合蛋白:
(BP)-(S)
x-(XTEN) I
其中在每次出現時,BP獨立地為如上文所描述之生物活性蛋白;S為可視情況包括裂解序列之具有1至約50個胺基酸殘基之間的間隔子序列(如下文更充分地描述);x為0或1;且XTEN為如上文所描述之延伸重組多肽。當BP針對所需生物活性需要游離N端時,或當其中BP之C端連接至融合蛋白降低生物活性時且當需要降低所投與之BPXTEN的生物活性及/或副作用時,實施例具有特定效用。
在BPXTEN組合物之另一實施例中,本發明提供式II之融合蛋白(如上文所描述之組分):
(XTEN)-(S)
x-(BP) II
其中在每次出現時,BP獨立地為如上文所描述之生物活性蛋白;S為可視情況包括裂解序列之具有1至約50個胺基酸殘基之間的間隔子序列(如下文更充分地描述);x為0或1;且XTEN為如上文所描述之延伸重組多肽。當BP針對所需生物活性需要游離C端時,或當其中BP之N端連接至融合蛋白降低生物活性時且當需要降低所投與之BPXTEN的生物活性及/或副作用時,實施例具有特定效用。
因此,具有單一BP及單一XTEN之BPXTEN可至少具有以下組態排列,各排列以N端至C端定向列出:BP-XTEN;XTEN-BP;BP-S-XTEN;或XTEN-S-BP。
在另一實施例中,本發明提供一種經分離之融合蛋白,其中該融合蛋白為式III之融合蛋白:
(BP)-(S)
x-(XTEN)-(S)
y-(BP)-(S)
z-(XTEN)
zIII
其中在每次出現時,BP獨立地為如上文所描述之生物活性蛋白;S為可視情況包括裂解序列之具有1至約50個胺基酸殘基之間的間隔子序列(如下文更充分地描述);x為0或1;y為0或1;z為0或1;且XTEN為如上文所描述之延伸重組多肽。
在另一實施例中,本發明提供一種經分離之融合蛋白,其中該融合蛋白為式IV之融合蛋白(如上文所描述之組分):
(XTEN)
x-(S)
y-(BP)-(S)
z-(XTEN)-(BP) IV
在另一實施例中,本發明提供一種經分離之融合蛋白,其中該融合蛋白為式V之融合蛋白(如上文所描述之組分):
(BP)
x-(S)
x-(BP)-(S)
y-(XTEN) V
在另一實施例中,本發明提供一種經分離之融合蛋白,其中該融合蛋白為式VI之融合蛋白(如上文所描述之組分):
(XTEN)-(S)
x-(BP)-(S)
y-(BP) VI
在另一實施例中,本發明提供一種經分離之融合蛋白,其中該融合蛋白為式VII之融合蛋白(如上文所描述之組分):
(XTEN)-(S)
x-(BP)-(S)
y-(BP)-(XTEN) VII
在一些情況下,BP可包含第一片段及第二細胞介素片段,且XTEN定位於第一片段與第二片段之間。必要時,BP可為細胞介素。在一些情況下,細胞介素可為IL-10。
在式I-VII之融合蛋白之前述實施例中,與不連接至XTEN之對應BP且以可比劑量向個體投與相比,向有需要之個體投與治療有效劑量之實施例之融合蛋白可產生,在融合蛋白之治療窗內花費之至少兩倍或至少三倍或至少四倍或至少五倍或更多倍的時間增益。
本發明涵蓋之融合蛋白中任何間隔子序列組視情況存在。可提供間隔子以增強融合蛋白自宿主細胞之表現或以降低位阻,使得BP組分可假定其所需三級結構及/或與其目標分子適當地相互作用。關於間隔子及識別所需間隔子之方法,參見例如George,等人. (2003) Protein Engineering 15:871-879,特定地以引用的方式併入本文中。在一個實施例中,間隔子包含一或多個長度在1至50個胺基酸殘基之間,或長度在約1至25個殘基,或長度在約1至10個殘基之間的肽序列。不包括裂解位點之間隔子序列可包含20種天然L胺基酸中之任一者,且將較佳包含空間上不受阻之親水性胺基酸,其可包括(但不限於)甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P)。在一些情況下,間隔子可為聚甘胺酸或聚丙胺酸,或主要為甘胺酸及丙胺酸殘基之組合的混合物。不包括裂解序列之間隔子多肽基本上不含二級結構。在一個實施例中,BPXTEN融合蛋白組合物中之一個或兩個間隔子序列可各自進一步含有可相同或可不同之裂解序列,其中裂解序列可由蛋白酶作用以自融合蛋白釋放BP。
在一些情況下,將裂解序列併入至BPXTEN中經設計以准許釋放在自XTEN釋放後變得活性或更具活性之BP。裂解序列足夠接近BP序列進行定位,通常在BP序列末端之18個胺基酸內,或12個胺基酸內,或6個胺基酸內,或2個胺基酸內定位,使得裂解之後連接至BP之任何殘留殘基不會明顯地干擾BP之活性(例如結合至受體),但提供足夠的蛋白酶以能夠實現裂解序列之裂解。在一些實施例中,裂解位點為序列,其可藉由對於哺乳動物個體而言為內源性的蛋白酶裂解以使得BPXTEN可在投與個體之後裂解。在此類情況下,BPXTEN可充當BP之前藥或循環儲存物。本發明涵蓋之裂解位點之實例包括(但不限於)可藉由哺乳動物內源性蛋白酶裂解之多肽序列,該哺乳動物內源性蛋白酶選自FXIa、FXIIa、激肽釋放素、FVIIa、FIXa、FXa、FIIa(凝血酶)、彈性蛋白酶-2、顆粒酶B、MMP-12、MMP-13、MMP-17或MMP-20,或藉由非哺乳動物蛋白酶裂解之多肽序列,該等非哺乳動物蛋白酶諸如TEV、腸激酶、PreScission™蛋白酶(鼻病毒3C蛋白酶)及分選酶A。已知由前述蛋白酶裂解之序列係此項技術中已知的。例示性裂解序列及序列內之切割位點以及序列變異體提供於
表 5中。舉例而言,凝血酶(活化凝血因子II)作用於序列LTPRSLLV(SEQ ID NO: 230)[Rawlings N.D.,等人 (2008)
Nucleic Acids Res.,
36: D320],其將在序列中之位置4處的精胺酸之後進行切割。類似地,其他序列併入至由內源性蛋白酶起作用之BPXTEN中將提供BP的持續釋放,在某些情況下,BP可能自BPXTEN之「前藥」形式為BP提供更高程度的活性。
在一些情況下,僅切割位點之兩側側接的兩個或三個胺基酸(總共四個至六個胺基酸)將併入裂解序列中。在其他情況下,已知裂解序列對於已知序列中之任一個或兩個或三個胺基酸可具有一或多個缺失或插入或一個或兩個或三個胺基酸取代,其中缺失、插入或取代導致對蛋白酶的敏感性降低或增強,但缺乏敏感性,從而得到調適自XTEN釋放BP之速率的能力。例示性取代展示於
表 5中。
表5:蛋白酶裂解序列
↓表示裂解位點
NA:不適用
*斜線之前、之間或之後的多個胺基酸之清單指示可在該位置經取代之替代性胺基酸;「-」指示任何胺基酸可經中間欄中指示之相應胺基酸取代。
作用於序列上之蛋白酶 | SEQ ID NO | 例示性裂解序列 | SEQ ID NO | 最小切割位點 * |
FXIa | 274 | KLTR↓ VVGG | 869 | KD/FL/T/R↓ VA/VE/GT/GV |
FXIIa | 275 | TMTR↓ IVGG | NA | NA |
激肽釋放酶 | 276 | SPFR↓ STGG | 870 | -/-/FL/RY↓ SR/RT/-/- |
FVIIa | 277 | LQVR↓ IVGG | NA | NA |
FIXa | 278 | PLGR↓ IVGG | 871 | -/-/G/R↓ -/-/-/- |
FXa | 279 | IEGR↓ TVGG | 872 | IA/E/GFP/R↓ STI/VFS/-/G |
FIIa(凝血酶) | 280 | LTPR↓ SLLV | 873 | -/-/PLA/R↓ SAG/-/-/- |
彈性蛋白酶-2 | 281 | LGPV↓ SGVP | 874 | -/-/-/VIAT↓ -/-/-/- |
顆粒酶-B | 282 | VAGD↓ SLEE | 875 | V/-/-/D↓ -/-/-/- |
MMP-12 | 283 | GPAG↓ LGGA | 876 | G/PA/-/G↓ L/-/G/- |
MMP-13 | 284 | GPAG↓ LRGA | 877 | G/P/-/G↓ L/-/GA/- |
MMP-17 | 285 | APLG↓ LRLR | 878 | -/PS/-/-↓ LQ/-/LT/- |
MMP-20 | 286 | PALP↓ LVAQ | NA | NA |
TEV | 287 | ENLYFQ↓ G | 879 | ENLYFQ↓ GS |
腸激酶 | 288 | DDDK↓ IVGG | 288 | DDDK↓ IVGG |
蛋白酶3C(PreScission TM) | 867 | LEVLFQ↓ GP | 867 | LEVLFQ↓ GP |
分選酶A | 868 | LPKT↓ GSES | 880 | L/P/KEAD/T↓ G/-/EKS/S |
在另一態樣中,本發明提供包含多個釋放區段(RS)之融合蛋白,其中各RS序列選自
表 6中所闡述之序列組,且RS藉由選自甘胺酸、絲胺酸、丙胺酸及蘇胺酸之1至6個胺基酸彼此連接。在一個實施例中,融合蛋白包含第一RS及不同於第一RS之第二RS,其中各RS序列選自
表 6中所闡述之序列組,且RS藉由選自甘胺酸、絲胺酸、丙胺酸及蘇胺酸之1至6個胺基酸彼此連接。在另一實施例中,融合蛋白包含第一RS、不同於第一RS之第二RS及不同於第一RS及第二RS之第三RS,其中各RS序列選自
表 6中所闡述之序列組,且第一及第二及第三RS藉由選自甘胺酸、絲胺酸、丙胺酸及蘇胺酸之1至6個胺基酸彼此連接。特定預期融合蛋白之多個RS可串接以形成序列,其可藉由不同裂解速率或劈裂效率之多個蛋白酶裂解。在另一實施例中,本揭示案提供融合蛋白,其包含選自表6及7中所闡述之序列組的RS1及RS2以及選自本揭示案的XTEN1及XTEN2,其中RS1融合於XTEN1與結合部分之間且RS2融合於XTEN2與結合部分之間。經考慮與健康組織或當在正常循環中時相比,此類組合物將更易於由表現多種蛋白酶之患病目標組織裂解,其結果為攜帶結合部分之所得片段將更易於穿透目標組織(例如腫瘤),且具有增強的結合及連接目標細胞及效應細胞(或僅在融合蛋白經設計為具有單一結合部分之情況下為目標細胞)之能力。在一些實施例中,在本揭示案之組合物(諸如融合蛋白)包含釋放區段的情況下,釋放區段(RS)可與選自
表 6 - 7中闡述之序列的序列具有至少82%、至少88%、至少94%或100%序列一致性。在一些實施例中,本揭示案之組合物(諸如融合蛋白)可具有自XTEN-RS-細胞介素或細胞介素-RS-XTEN之N端至C端的結構排列。
表6. 釋放區段序列.
表7. 釋放區段序列
名稱 | 構築體 ID | 胺基酸序列 |
BSRS-4 | AC1602 | LAGRSDNHSPLGLAGS(SEQ ID NO: 20) |
BSRS-5 | AC1603 | LAGRSDNHVPLSLSMG(SEQ ID NO: 21) |
BSRS-6 | AC1604 | LAGRSDNHEPLELVAG(SEQ ID NO: 22) |
BSRS-A1-1 | AC1605 | ASGRSTNAGPSGLAGP(SEQ ID NO: 23) |
BSRS-A2-1 | AC1606 | ASGRSTNAGPQGLAGQ(SEQ ID NO: 24) |
BSRS-A3-1 | AC1607 | ASGRSTNAGPPGLTGP(SEQ ID NO: 25) |
VP-1 | AC1608 | ASSRGTNAGPAGLTGP(SEQ ID NO: 26) |
RSR-1752 | AC1609 | ASSRTTNTGPSTLTGP(SEQ ID NO: 27) |
RSR-1512 | AC1610 | AAGRSDNGTPLELVAP(SEQ ID NO: 28) |
RSR-1517 | AC1611 | EAGRSANHEPLGLVAT(SEQ ID NO: 29) |
VP-2 | AC1612 | ASGRGTNAGPAGLTGP(SEQ ID NO: 30) |
RSR-1018 | AC1613 | LFGRNDNHEPLELGGG(SEQ ID NO: 31) |
RSR-1053 | AC1614 | TAGRSDNLEPLGLVFG(SEQ ID NO: 32) |
RSR-1059 | AC1615 | LDGRSDNFHPPELVAG(SEQ ID NO: 33) |
RSR-1065 | AC1616 | LEGRSDNEEPENLVAG(SEQ ID NO: 34) |
RSR-1167 | AC1617 | LKGRSDNNAPLALVAG(SEQ ID NO: 35) |
RSR-1201 | AC1618 | VYSRGTNAGPHGLTGR(SEQ ID NO: 36) |
RSR-1218 | AC1619 | ANSRGTNKGFAGLIGP(SEQ ID NO: 37) |
RSR-1226 | AC1620 | ASSRLTNEAPAGLTIP(SEQ ID NO: 38) |
RSR-1254 | AC1621 | DQSRGTNAGPEGLTDP(SEQ ID NO: 39) |
RSR-1256 | AC1622 | ESSRGTNIGQGGLTGP(SEQ ID NO: 40) |
RSR-1261 | AC1623 | SSSRGTNQDPAGLTIP(SEQ ID NO: 41) |
RSR-1293 | AC1624 | ASSRGQNHSPMGLTGP(SEQ ID NO: 42) |
RSR-1309 | AC1625 | AYSRGPNAGPAGLEGR(SEQ ID NO: 43) |
RSR-1326 | AC1626 | ASERGNNAGPANLTGF(SEQ ID NO: 44) |
RSR-1345 | AC1627 | ASHRGTNPKPAILTGP(SEQ ID NO: 45) |
RSR-1354 | AC1628 | MSSRRTNANPAQLTGP(SEQ ID NO: 46) |
RSR-1426 | AC1629 | GAGRTDNHEPLELGAA(SEQ ID NO: 47) |
RSR-1478 | AC1630 | LAGRSENTAPLELTAG(SEQ ID NO: 48) |
RSR-1479 | AC1631 | LEGRPDNHEPLALVAS(SEQ ID NO: 49) |
RSR-1496 | AC1632 | LSGRSDNEEPLALPAG(SEQ ID NO: 50) |
RSR-1508 | AC1633 | EAGRTDNHEPLELSAP(SEQ ID NO: 51) |
RSR-1513 | AC1634 | EGGRSDNHGPLELVSG(SEQ ID NO: 52) |
RSR-1516 | AC1635 | LSGRSDNEAPLELEAG(SEQ ID NO: 53) |
RSR-1524 | AC1636 | LGGRADNHEPPELGAG(SEQ ID NO: 54) |
RSR-1622 | AC1637 | PPSRGTNAEPAGLTGE(SEQ ID NO: 55) |
RSR-1629 | AC1638 | ASTRGENAGPAGLEAP(SEQ ID NO: 56) |
RSR-1664 | AC1639 | ESSRGTNGAPEGLTGP(SEQ ID NO: 57) |
RSR-1667 | AC1640 | ASSRATNESPAGLTGE(SEQ ID NO: 58) |
RSR-1709 | AC1641 | ASSRGENPPPGGLTGP(SEQ ID NO: 59) |
RSR-1712 | AC1642 | AASRGTNTGPAELTGS(SEQ ID NO: 60) |
RSR-1727 | AC1643 | AGSRTTNAGPGGLEGP(SEQ ID NO: 61) |
RSR-1754 | AC1644 | APSRGENAGPATLTGA(SEQ ID NO: 62) |
RSR-1819 | AC1645 | ESGRAANTGPPTLTAP(SEQ ID NO: 63) |
RSR-1832 | AC1646 | NPGRAANEGPPGLPGS(SEQ ID NO: 64) |
RSR-1855 | AC1647 | ESSRAANLTPPELTGP(SEQ ID NO: 65) |
RSR-1911 | AC1648 | ASGRAANETPPGLTGA(SEQ ID NO: 66) |
RSR-1929 | AC1649 | NSGRGENLGAPGLTGT(SEQ ID NO: 67) |
RSR-1951 | AC1650 | TTGRAANLTPAGLTGP(SEQ ID NO: 68) |
RSR-2295 | AC1761 | EAGRSANHTPAGLTGP(SEQ ID NO: 69) |
RSR-2298 | AC1762 | ESGRAANTTPAGLTGP(SEQ ID NO: 70) |
RSR-2038 | AC1679 | TTGRATEAANLTPAGLTGP(SEQ ID NO: 71) |
RSR-2072 | AC1680 | TTGRAEEAANLTPAGLTGP(SEQ ID NO: 72) |
RSR-2089 | AC1681 | TTGRAGEAANLTPAGLTGP(SEQ ID NO: 73) |
RSR-2302 | AC1682 | TTGRATEAANATPAGLTGP(SEQ ID NO: 74) |
RSR-3047 | AC1697 | TTGRAGEAEGATSAGATGP(SEQ ID NO: 75) |
RSR-3052 | AC1698 | TTGEAGEAANATSAGATGP(SEQ ID NO: 76) |
RSR-3043 | AC1699 | TTGEAGEAAGLTPAGLTGP(SEQ ID NO: 77) |
RSR-3041 | AC1700 | TTGAAGEAANATPAGLTGP(SEQ ID NO: 78) |
RSR-3044 | AC1701 | TTGRAGEAAGLTPAGLTGP(SEQ ID NO: 79) |
RSR-3057 | AC1702 | TTGRAGEAANATSAGATGP(SEQ ID NO: 80) |
RSR-3058 | AC1703 | TTGEAGEAAGATSAGATGP(SEQ ID NO: 81) |
RSR-2485 | AC1763 | ESGRAANTEPPELGAG(SEQ ID NO: 82) |
RSR-2486 | AC1764 | ESGRAANTAPEGLTGP(SEQ ID NO: 83) |
RSR-2488 | AC1688 | EPGRAANHEPSGLTEG(SEQ ID NO: 84) |
RSR-2599 | AC1706 | ESGRAANHTGAPPGGLTGP(SEQ ID NO: 85) |
RSR-2706 | AC1716 | TTGRTGEGANATPGGLTGP(SEQ ID NO: 86) |
RSR-2707 | AC1717 | RTGRSGEAANETPEGLEGP(SEQ ID NO: 87) |
RSR-2708 | AC1718 | RTGRTGESANETPAGLGGP(SEQ ID NO: 88) |
RSR-2709 | AC1719 | STGRTGEPANETPAGLSGP(SEQ ID NO: 89) |
RSR-2710 | AC1720 | TTGRAGEPANATPTGLSGP(SEQ ID NO: 90) |
RSR-2711 | AC1721 | RTGRPGEGANATPTGLPGP(SEQ ID NO: 91) |
RSR-2712 | AC1722 | RTGRGGEAANATPSGLGGP(SEQ ID NO: 92) |
RSR-2713 | AC1723 | STGRSGESANATPGGLGGP(SEQ ID NO: 93) |
RSR-2714 | AC1724 | RTGRTGEEANATPAGLPGP(SEQ ID NO: 94) |
RSR-2715 | AC1725 | ATGRPGEPANTTPEGLEGP(SEQ ID NO: 95) |
RSR-2716 | AC1726 | STGRSGEPANATPGGLTGP(SEQ ID NO: 96) |
RSR-2717 | AC1727 | PTGRGGEGANTTPTGLPGP(SEQ ID NO: 97) |
RSR-2718 | AC1728 | PTGRSGEGANATPSGLTGP(SEQ ID NO: 98) |
RSR-2719 | AC1729 | TTGRASEGANSTPAPLTEP(SEQ ID NO: 99) |
RSR-2720 | AC1730 | TYGRAAEAANTTPAGLTAP(SEQ ID NO: 100) |
RSR-2721 | AC1731 | TTGRATEGANATPAELTEP(SEQ ID NO: 101) |
RSR-2722 | AC1732 | TVGRASEEANTTPASLTGP(SEQ ID NO: 102) |
RSR-2723 | AC1733 | TTGRAPEAANATPAPLTGP(SEQ ID NO: 103) |
RSR-2724 | AC1734 | TWGRATEPANATPAPLTSP(SEQ ID NO: 104) |
RSR-2725 | AC1735 | TVGRASESANATPAELTSP(SEQ ID NO: 105) |
RSR-2726 | AC1736 | TVGRAPEGANSTPAGLTGP(SEQ ID NO: 106) |
RSR-2727 | AC1737 | TWGRATEAPNLEPATLTTP(SEQ ID NO: 107) |
RSR-2728 | AC1738 | TTGRATEAPNLTPAPLTEP(SEQ ID NO: 108) |
RSR-2729 | AC1739 | TQGRATEAPNLSPAALTSP(SEQ ID NO: 109) |
RSR-2730 | AC1740 | TQGRAAEAPNLTPATLTAP(SEQ ID NO: 110) |
RSR-2731 | AC1741 | TSGRAPEATNLAPAPLTGP(SEQ ID NO: 111) |
RSR-2732 | AC1742 | TQGRAAEAANLTPAGLTEP(SEQ ID NO: 112) |
RSR-2733 | AC1743 | TTGRAGSAPNLPPTGLTTP(SEQ ID NO: 113) |
RSR-2734 | AC1744 | TTGRAGGAENLPPEGLTAP(SEQ ID NO: 114) |
RSR-2735 | AC1745 | TTSRAGTATNLTPEGLTAP(SEQ ID NO: 115) |
RSR-2736 | AC1746 | TTGRAGTATNLPPSGLTTP(SEQ ID NO: 116) |
RSR-2737 | AC1747 | TTARAGEAENLSPSGLTAP(SEQ ID NO: 117) |
RSR-2738 | AC1748 | TTGRAGGAGNLAPGGLTEP(SEQ ID NO: 118) |
RSR-2739 | AC1749 | TTGRAGTATNLPPEGLTGP(SEQ ID NO: 119) |
RSR-2740 | AC1750 | TTGRAGGAANLAPTGLTEP(SEQ ID NO: 120) |
RSR-2741 | AC1751 | TTGRAGTAENLAPSGLTTP(SEQ ID NO: 121) |
RSR-2742 | AC1752 | TTGRAGSATNLGPGGLTGP(SEQ ID NO: 122) |
RSR-2743 | AC1753 | TTARAGGAENLTPAGLTEP(SEQ ID NO: 123) |
RSR-2744 | AC1754 | TTARAGSAENLSPSGLTGP(SEQ ID NO: 124) |
RSR-2745 | AC1755 | TTARAGGAGNLAPEGLTTP(SEQ ID NO: 125) |
RSR-2746 | AC1756 | TTSRAGAAENLTPTGLTGP(SEQ ID NO: 126) |
RSR-2747 | AC1757 | TYGRTTTPGNEPPASLEAE(SEQ ID NO: 127) |
RSR-2748 | AC1758 | TYSRGESGPNEPPPGLTGP(SEQ ID NO: 128) |
RSR-2749 | AC1759 | AWGRTGASENETPAPLGGE(SEQ ID NO: 129) |
RSR-2750 | AC1760 | RWGRAETTPNTPPEGLETE(SEQ ID NO: 130) |
RSR-2751 | AC1765 | ESGRAANHTGAEPPELGAG(SEQ ID NO: 131) |
RSR-2754 | AC1801 | TTGRAGEAANLTPAGLTES(SEQ ID NO: 132) |
RSR-2755 | AC1802 | TTGRAGEAANLTPAALTES(SEQ ID NO: 133) |
RSR-2756 | AC1803 | TTGRAGEAANLTPAPLTES(SEQ ID NO: 134) |
RSR-2757 | AC1804 | TTGRAGEAANLTPEPLTES(SEQ ID NO: 135) |
RSR-2758 | AC1805 | TTGRAGEAANLTPAGLTGA(SEQ ID NO: 136) |
RSR-2759 | AC1806 | TTGRAGEAANLTPEGLTGA(SEQ ID NO: 137) |
RSR-2760 | AC1807 | TTGRAGEAANLTPEPLTGA(SEQ ID NO: 138) |
RSR-2761 | AC1808 | TTGRAGEAANLTPAGLTEA(SEQ ID NO: 139) |
RSR-2762 | AC1809 | TTGRAGEAANLTPEGLTEA(SEQ ID NO: 140) |
RSR-2763 | AC1810 | TTGRAGEAANLTPAPLTEA(SEQ ID NO: 141) |
RSR-2764 | AC1811 | TTGRAGEAANLTPEPLTEA(SEQ ID NO: 142) |
RSR-2765 | AC1812 | TTGRAGEAANLTPEPLTGP(SEQ ID NO: 143) |
RSR-2766 | AC1813 | TTGRAGEAANLTPAGLTGG(SEQ ID NO: 144) |
RSR-2767 | AC1814 | TTGRAGEAANLTPEGLTGG(SEQ ID NO: 145) |
RSR-2768 | AC1815 | TTGRAGEAANLTPEALTGG(SEQ ID NO: 146) |
RSR-2769 | AC1816 | TTGRAGEAANLTPEPLTGG(SEQ ID NO: 147) |
RSR-2770 | AC1817 | TTGRAGEAANLTPAGLTEG(SEQ ID NO: 148) |
RSR-2771 | AC1818 | TTGRAGEAANLTPEGLTEG(SEQ ID NO: 149) |
RSR-2772 | AC1819 | TTGRAGEAANLTPAPLTEG(SEQ ID NO: 150) |
RSR-2773 | AC1820 | TTGRAGEAANLTPEPLTEG(SEQ ID NO: 151) |
名稱 | 胺基酸序列 | 名稱 | 胺基酸序列 |
RSN-0001 | GSAPGSAGGYAELRMGGAIATSGSETPGT(SEQ ID NO: 335) | RSC-0001 | GTAEAASASGGSAGGYAELRMGGAIPGSP(SEQ ID NO: 583) |
RSN-0002 | GSAPGTGGGYAPLRMGGGAATSGSETPGT(SEQ ID NO: 336) | RSC-0002 | GTAEAASASGGTGGGYAPLRMGGGAPGSP(SEQ ID NO: 584) |
RSN-0003 | GSAPGAEGGYAALRMGGEIATSGSETPGT(SEQ ID NO: 337) | RSC-0003 | GTAEAASASGGAEGGYAALRMGGEIPGSP(SEQ ID NO: 585) |
RSN-0004 | GSAPGGPGGYALLRMGGPAATSGSETPGT(SEQ ID NO: 338) | RSC-0004 | GTAEAASASGGGPGGYALLRMGGPAPGSP(SEQ ID NO: 586) |
RSN-0005 | GSAPGEAGGYAFLRMGGSIATSGSETPGT(SEQ ID NO: 339) | RSC-0005 | GTAEAASASGGEAGGYAFLRMGGSIPGSP(SEQ ID NO: 587) |
RSN-0006 | GSAPGPGGGYASLRMGGTAATSGSETPGT(SEQ ID NO: 340) | RSC-0006 | GTAEAASASGGPGGGYASLRMGGTAPGSP(SEQ ID NO: 588) |
RSN-0007 | GSAPGSEGGYATLRMGGAIATSGSETPGT(SEQ ID NO: 341) | RSC-0007 | GTAEAASASGGSEGGYATLRMGGAIPGSP(SEQ ID NO: 589) |
RSN-0008 | GSAPGTPGGYANLRMGGGAATSGSETPGT(SEQ ID NO: 342) | RSC-0008 | GTAEAASASGGTPGGYANLRMGGGAPGSP(SEQ ID NO: 590) |
RSN-0009 | GSAPGASGGYAHLRMGGEIATSGSETPGT(SEQ ID NO: 343) | RSC-0009 | GTAEAASASGGASGGYAHLRMGGEIPGSP(SEQ ID NO: 591) |
RSN-0010 | GSAPGGTGGYGELRMGGPAATSGSETPGT(SEQ ID NO: 344) | RSC-0010 | GTAEAASASGGGTGGYGELRMGGPAPGSP(SEQ ID NO: 592) |
RSN-0011 | GSAPGEAGGYPELRMGGSIATSGSETPGT(SEQ ID NO: 345) | RSC-0011 | GTAEAASASGGEAGGYPELRMGGSIPGSP(SEQ ID NO: 593) |
RSN-0012 | GSAPGPGGGYVELRMGGTAATSGSETPGT(SEQ ID NO: 346) | RSC-0012 | GTAEAASASGGPGGGYVELRMGGTAPGSP(SEQ ID NO: 594) |
RSN-0013 | GSAPGSEGGYLELRMGGAIATSGSETPGT(SEQ ID NO: 347) | RSC-0013 | GTAEAASASGGSEGGYLELRMGGAIPGSP(SEQ ID NO: 595) |
RSN-0014 | GSAPGTPGGYSELRMGGGAATSGSETPGT(SEQ ID NO: 348) | RSC-0014 | GTAEAASASGGTPGGYSELRMGGGAPGSP(SEQ ID NO: 596) |
RSN-0015 | GSAPGASGGYTELRMGGEIATSGSETPGT(SEQ ID NO: 349) | RSC-0015 | GTAEAASASGGASGGYTELRMGGEIPGSP(SEQ ID NO: 597) |
RSN-0016 | GSAPGGTGGYQELRMGGPAATSGSETPGT(SEQ ID NO: 350) | RSC-0016 | GTAEAASASGGGTGGYQELRMGGPAPGSP(SEQ ID NO: 598) |
RSN-0017 | GSAPGEAGGYEELRMGGSIATSGSETPGT(SEQ ID NO: 351) | RSC-0017 | GTAEAASASGGEAGGYEELRMGGSIPGSP(SEQ ID NO: 599) |
RSN-0018 | GSAPGPGIGPAELRMGGTAATSGSETPGT(SEQ ID NO: 352) | RSC-0018 | GTAEAASASGGPGIGPAELRMGGTAPGSP(SEQ ID NO: 600) |
RSN-0019 | GSAPGSEIGAAELRMGGAIATSGSETPGT(SEQ ID NO: 353) | RSC-0019 | GTAEAASASGGSEIGAAELRMGGAIPGSP(SEQ ID NO: 601) |
RSN-0020 | GSAPGTPIGSAELRMGGGAATSGSETPGT(SEQ ID NO: 354) | RSC-0020 | GTAEAASASGGTPIGSAELRMGGGAPGSP(SEQ ID NO: 602) |
RSN-0021 | GSAPGASIGTAELRMGGEIATSGSETPGT(SEQ ID NO: 355) | RSC-0021 | GTAEAASASGGASIGTAELRMGGEIPGSP(SEQ ID NO: 603) |
RSN-0022 | GSAPGGTIGNAELRMGGPAATSGSETPGT(SEQ ID NO: 356) | RSC-0022 | GTAEAASASGGGTIGNAELRMGGPAPGSP(SEQ ID NO: 604) |
RSN-0023 | GSAPGEAIGQAELRMGGSIATSGSETPGT(SEQ ID NO: 357) | RSC-0023 | GTAEAASASGGEAIGQAELRMGGSIPGSP(SEQ ID NO: 605) |
RSN-0024 | GSAPGPGGPYAELRMGGTAATSGSETPGT(SEQ ID NO: 358) | RSC-0024 | GTAEAASASGGPGGPYAELRMGGTAPGSP(SEQ ID NO: 606) |
RSN-0025 | GSAPGSEGAYAELRMGGAIATSGSETPGT(SEQ ID NO: 359) | RSC-0025 | GTAEAASASGGSEGAYAELRMGGAIPGSP(SEQ ID NO: 607) |
RSN-0026 | GSAPGTPGVYAELRMGGGAATSGSETPGT(SEQ ID NO: 360) | RSC-0026 | GTAEAASASGGTPGVYAELRMGGGAPGSP(SEQ ID NO: 608) |
RSN-0027 | GSAPGASGLYAELRMGGEIATSGSETPGT(SEQ ID NO: 361) | RSC-0027 | GTAEAASASGGASGLYAELRMGGEIPGSP(SEQ ID NO: 609) |
RSN-0028 | GSAPGGTGIYAELRMGGPAATSGSETPGT(SEQ ID NO: 362) | RSC-0028 | GTAEAASASGGGTGIYAELRMGGPAPGSP(SEQ ID NO: 610) |
RSN-0029 | GSAPGEAGFYAELRMGGSIATSGSETPGT(SEQ ID NO: 363) | RSC-0029 | GTAEAASASGGEAGFYAELRMGGSIPGSP(SEQ ID NO: 611) |
RSN-0030 | GSAPGPGGYYAELRMGGTAATSGSETPGT(SEQ ID NO: 364) | RSC-0030 | GTAEAASASGGPGGYYAELRMGGTAPGSP(SEQ ID NO: 612) |
RSN-0031 | GSAPGSEGSYAELRMGGAIATSGSETPGT(SEQ ID NO: 365) | RSC-0031 | GTAEAASASGGSEGSYAELRMGGAIPGSP(SEQ ID NO: 613) |
RSN-0032 | GSAPGTPGNYAELRMGGGAATSGSETPGT(SEQ ID NO: 366) | RSC-0032 | GTAEAASASGGTPGNYAELRMGGGAPGSP(SEQ ID NO: 614) |
RSN-0033 | GSAPGASGEYAELRMGGEIATSGSETPGT(SEQ ID NO: 367) | RSC-0033 | GTAEAASASGGASGEYAELRMGGEIPGSP(SEQ ID NO: 615) |
RSN-0034 | GSAPGGTGHYAELRMGGPAATSGSETPGT(SEQ ID NO: 368) | RSC-0034 | GTAEAASASGGGTGHYAELRMGGPAPGSP(SEQ ID NO: 616) |
RSN-0035 | GSAPGEAGGYAEARMGGSIATSGSETPGT(SEQ ID NO: 369) | RSC-0035 | GTAEAASASGGEAGGYAEARMGGSIPGSP(SEQ ID NO: 617) |
RSN-0036 | GSAPGPGGGYAEVRMGGTAATSGSETPGT(SEQ ID NO: 370) | RSC-0036 | GTAEAASASGGPGGGYAEVRMGGTAPGSP(SEQ ID NO: 618) |
RSN-0037 | GSAPGSEGGYAEIRMGGAIATSGSETPGT(SEQ ID NO: 371) | RSC-0037 | GTAEAASASGGSEGGYAEIRMGGAIPGSP(SEQ ID NO: 619) |
RSN-0038 | GSAPGTPGGYAEFRMGGGAATSGSETPGT(SEQ ID NO: 372) | RSC-0038 | GTAEAASASGGTPGGYAEFRMGGGAPGSP(SEQ ID NO: 620) |
RSN-0039 | GSAPGASGGYAEYRMGGEIATSGSETPGT(SEQ ID NO: 373) | RSC-0039 | GTAEAASASGGASGGYAEYRMGGEIPGSP(SEQ ID NO: 621) |
RSN-0040 | GSAPGGTGGYAESRMGGPAATSGSETPGT(SEQ ID NO: 374) | RSC-0040 | GTAEAASASGGGTGGYAESRMGGPAPGSP(SEQ ID NO: 622) |
RSN-0041 | GSAPGEAGGYAETRMGGSIATSGSETPGT(SEQ ID NO: 375) | RSC-0041 | GTAEAASASGGEAGGYAETRMGGSIPGSP(SEQ ID NO: 623) |
RSN-0042 | GSAPGPGGGYAELAMGGTRATSGSETPGT(SEQ ID NO: 376) | RSC-0042 | GTAEAASASGGPGGGYAELAMGGTRPGSP(SEQ ID NO: 624) |
RSN-0043 | GSAPGSEGGYAELVMGGARATSGSETPGT(SEQ ID NO: 377) | RSC-0043 | GTAEAASASGGSEGGYAELVMGGARPGSP(SEQ ID NO: 625) |
RSN-0044 | GSAPGTPGGYAELLMGGGRATSGSETPGT(SEQ ID NO: 378) | RSC-0044 | GTAEAASASGGTPGGYAELLMGGGRPGSP(SEQ ID NO: 626) |
RSN-0045 | GSAPGASGGYAELIMGGERATSGSETPGT(SEQ ID NO: 379) | RSC-0045 | GTAEAASASGGASGGYAELIMGGERPGSP(SEQ ID NO: 627) |
RSN-0046 | GSAPGGTGGYAELWMGGPRATSGSETPGT(SEQ ID NO: 380) | RSC-0046 | GTAEAASASGGGTGGYAELWMGGPRPGSP(SEQ ID NO: 628) |
RSN-0047 | GSAPGEAGGYAELSMGGSRATSGSETPGT(SEQ ID NO: 381) | RSC-0047 | GTAEAASASGGEAGGYAELSMGGSRPGSP(SEQ ID NO: 629) |
RSN-0048 | GSAPGPGGGYAELTMGGTRATSGSETPGT(SEQ ID NO: 382) | RSC-0048 | GTAEAASASGGPGGGYAELTMGGTRPGSP(SEQ ID NO: 630) |
RSN-0049 | GSAPGSEGGYAELQMGGARATSGSETPGT(SEQ ID NO: 383) | RSC-0049 | GTAEAASASGGSEGGYAELQMGGARPGSP(SEQ ID NO: 631) |
RSN-0050 | GSAPGTPGGYAELNMGGGRATSGSETPGT(SEQ ID NO: 384) | RSC-0050 | GTAEAASASGGTPGGYAELNMGGGRPGSP(SEQ ID NO: 632) |
RSN-0051 | GSAPGASGGYAELEMGGERATSGSETPGT(SEQ ID NO: 385) | RSC-0051 | GTAEAASASGGASGGYAELEMGGERPGSP(SEQ ID NO: 633) |
RSN-0052 | GSAPGGTGGYAELRPGGPIATSGSETPGT(SEQ ID NO: 386) | RSC-0052 | GTAEAASASGGGTGGYAELRPGGPIPGSP(SEQ ID NO: 634) |
RSN-0053 | GSAPGEAGGYAELRAGGSAATSGSETPGT(SEQ ID NO: 387) | RSC-0053 | GTAEAASASGGEAGGYAELRAGGSAPGSP(SEQ ID NO: 635) |
RSN-0054 | GSAPGPGGGYAELRLGGTIATSGSETPGT(SEQ ID NO: 388) | RSC-0054 | GTAEAASASGGPGGGYAELRLGGTIPGSP(SEQ ID NO: 636) |
RSN-0055 | GSAPGSEGGYAELRIGGAAATSGSETPGT(SEQ ID NO: 389) | RSC-0055 | GTAEAASASGGSEGGYAELRIGGAAPGSP(SEQ ID NO: 637) |
RSN-0056 | GSAPGTPGGYAELRSGGGIATSGSETPGT(SEQ ID NO: 390) | RSC-0056 | GTAEAASASGGTPGGYAELRSGGGIPGSP(SEQ ID NO: 638) |
RSN-0057 | GSAPGASGGYAELRNGGEAATSGSETPGT(SEQ ID NO: 391) | RSC-0057 | GTAEAASASGGASGGYAELRNGGEAPGSP(SEQ ID NO: 639) |
RSN-0058 | GSAPGGTGGYAELRQGGPIATSGSETPGT(SEQ ID NO: 392) | RSC-0058 | GTAEAASASGGGTGGYAELRQGGPIPGSP(SEQ ID NO: 640) |
RSN-0059 | GSAPGEAGGYAELRDGGSAATSGSETPGT(SEQ ID NO: 393) | RSC-0059 | GTAEAASASGGEAGGYAELRDGGSAPGSP(SEQ ID NO: 641) |
RSN-0060 | GSAPGPGGGYAELREGGTIATSGSETPGT(SEQ ID NO: 394) | RSC-0060 | GTAEAASASGGPGGGYAELREGGTIPGSP(SEQ ID NO: 642) |
RSN-0061 | GSAPGSEGGYAELRHGGAAATSGSETPGT(SEQ ID NO: 395) | RSC-0061 | GTAEAASASGGSEGGYAELRHGGAAPGSP(SEQ ID NO: 643) |
RSN-0062 | GSAPGTPGGYAELRMPGGIATSGSETPGT(SEQ ID NO: 396) | RSC-0062 | GTAEAASASGGTPGGYAELRMPGGIPGSP(SEQ ID NO: 644) |
RSN-0063 | GSAPGASGGYAELRMAGEAATSGSETPGT(SEQ ID NO: 397) | RSC-0063 | GTAEAASASGGASGGYAELRMAGEAPGSP(SEQ ID NO: 645) |
RSN-0064 | GSAPGGTGGYAELRMVGPIATSGSETPGT(SEQ ID NO: 398) | RSC-0064 | GTAEAASASGGGTGGYAELRMVGPIPGSP(SEQ ID NO: 646) |
RSN-0065 | GSAPGEAGGYAELRMLGSAATSGSETPGT(SEQ ID NO: 399) | RSC-0065 | GTAEAASASGGEAGGYAELRMLGSAPGSP(SEQ ID NO: 647) |
RSN-0066 | GSAPGPGGGYAELRMIGTIATSGSETPGT(SEQ ID NO: 400) | RSC-0066 | GTAEAASASGGPGGGYAELRMIGTIPGSP(SEQ ID NO: 648) |
RSN-0067 | GSAPGSEGGYAELRMYGAIATSGSETPGT(SEQ ID NO: 401) | RSC-0067 | GTAEAASASGGSEGGYAELRMYGAIPGSP(SEQ ID NO: 649) |
RSN-0068 | GSAPGTPGGYAELRMSGGAATSGSETPGT(SEQ ID NO: 402) | RSC-0068 | GTAEAASASGGTPGGYAELRMSGGAPGSP(SEQ ID NO: 650) |
RSN-0069 | GSAPGASGGYAELRMNGEIATSGSETPGT(SEQ ID NO: 403) | RSC-0069 | GTAEAASASGGASGGYAELRMNGEIPGSP(SEQ ID NO: 651) |
RSN-0070 | GSAPGGTGGYAELRMQGPAATSGSETPGT(SEQ ID NO: 404) | RSC-0070 | GTAEAASASGGGTGGYAELRMQGPAPGSP(SEQ ID NO: 652) |
RSN-0071 | GSAPGANHTPAGLTGPGARATSGSETPGT(SEQ ID NO: 405) | RSC-0071 | GTAEAASASGGANHTPAGLTGPGARPGSP(SEQ ID NO: 653) |
RSN-0072 | GSAPGANTAPEGLTGPSTRATSGSETPGT(SEQ ID NO: 406) | RSC-0072 | GTAEAASASGGANTAPEGLTGPSTRPGSP(SEQ ID NO: 654) |
RSN-0073 | GSAPGTGAPPGGLTGPGTRATSGSETPGT(SEQ ID NO: 407) | RSC-0073 | GTAEAASASGGTGAPPGGLTGPGTRPGSP(SEQ ID NO: 655) |
RSN-0074 | GSAPGANHEPSGLTEGSPRATSGSETPGT(SEQ ID NO: 408) | RSC-0074 | GTAEAASASGGANHEPSGLTEGSPRPGSP(SEQ ID NO: 656) |
RSN-0075 | GSAPGANTEPPELGAGTERATSGSETPGT(SEQ ID NO: 409) | RSC-0075 | GTAEAASASGGANTEPPELGAGTERPGSP(SEQ ID NO: 657) |
RSN-0076 | GSAPGASGPPPGLTGPPGRATSGSETPGT(SEQ ID NO: 410) | RSC-0076 | GTAEAASASGGASGPPPGLTGPPGRPGSP(SEQ ID NO: 658) |
RSN-0077 | GSAPGASGTPAPLGGEPGRATSGSETPGT(SEQ ID NO: 411) | RSC-0077 | GTAEAASASGGASGTPAPLGGEPGRPGSP(SEQ ID NO: 659) |
RSN-0078 | GSAPGPAGPPEGLETEAGRATSGSETPGT(SEQ ID NO: 412) | RSC-0078 | GTAEAASASGGPAGPPEGLETEAGRPGSP(SEQ ID NO: 660) |
RSN-0079 | GSAPGPTSGQGGLTGPESRATSGSETPGT(SEQ ID NO: 413) | RSC-0079 | GTAEAASASGGPTSGQGGLTGPESRPGSP(SEQ ID NO: 661) |
RSN-0080 | GSAPGSAGGAANLVRGGAIATSGSETPGT(SEQ ID NO: 414) | RSC-0080 | GTAEAASASGGSAGGAANLVRGGAIPGSP(SEQ ID NO: 662) |
RSN-0081 | GSAPGTGGGAAPLVRGGGAATSGSETPGT(SEQ ID NO: 415) | RSC-0081 | GTAEAASASGGTGGGAAPLVRGGGAPGSP(SEQ ID NO: 663) |
RSN-0082 | GSAPGAEGGAAALVRGGEIATSGSETPGT(SEQ ID NO: 416) | RSC-0082 | GTAEAASASGGAEGGAAALVRGGEIPGSP(SEQ ID NO: 664) |
RSN-0083 | GSAPGGPGGAALLVRGGPAATSGSETPGT(SEQ ID NO: 417) | RSC-0083 | GTAEAASASGGGPGGAALLVRGGPAPGSP(SEQ ID NO: 665) |
RSN-0084 | GSAPGEAGGAAFLVRGGSIATSGSETPGT(SEQ ID NO: 418) | RSC-0084 | GTAEAASASGGEAGGAAFLVRGGSIPGSP(SEQ ID NO: 666) |
RSN-0085 | GSAPGPGGGAASLVRGGTAATSGSETPGT(SEQ ID NO: 419) | RSC-0085 | GTAEAASASGGPGGGAASLVRGGTAPGSP(SEQ ID NO: 667) |
RSN-0086 | GSAPGSEGGAATLVRGGAIATSGSETPGT(SEQ ID NO: 420) | RSC-0086 | GTAEAASASGGSEGGAATLVRGGAIPGSP(SEQ ID NO: 668) |
RSN-0087 | GSAPGTPGGAAGLVRGGGAATSGSETPGT(SEQ ID NO: 421) | RSC-0087 | GTAEAASASGGTPGGAAGLVRGGGAPGSP(SEQ ID NO: 669) |
RSN-0088 | GSAPGASGGAADLVRGGEIATSGSETPGT(SEQ ID NO: 422) | RSC-0088 | GTAEAASASGGASGGAADLVRGGEIPGSP(SEQ ID NO: 670) |
RSN-0089 | GSAPGGTGGAGNLVRGGPAATSGSETPGT(SEQ ID NO: 423) | RSC-0089 | GTAEAASASGGGTGGAGNLVRGGPAPGSP(SEQ ID NO: 671) |
RSN-0090 | GSAPGEAGGAPNLVRGGSIATSGSETPGT(SEQ ID NO: 424) | RSC-0090 | GTAEAASASGGEAGGAPNLVRGGSIPGSP(SEQ ID NO: 672) |
RSN-0091 | GSAPGPGGGAVNLVRGGTAATSGSETPGT(SEQ ID NO: 425) | RSC-0091 | GTAEAASASGGPGGGAVNLVRGGTAPGSP(SEQ ID NO: 673) |
RSN-0092 | GSAPGSEGGALNLVRGGAIATSGSETPGT(SEQ ID NO: 426) | RSC-0092 | GTAEAASASGGSEGGALNLVRGGAIPGSP(SEQ ID NO: 674) |
RSN-0093 | GSAPGTPGGASNLVRGGGAATSGSETPGT(SEQ ID NO: 427) | RSC-0093 | GTAEAASASGGTPGGASNLVRGGGAPGSP(SEQ ID NO: 675) |
RSN-0094 | GSAPGASGGATNLVRGGEIATSGSETPGT(SEQ ID NO: 428) | RSC-0094 | GTAEAASASGGASGGATNLVRGGEIPGSP(SEQ ID NO: 676) |
RSN-0095 | GSAPGGTGGAQNLVRGGPAATSGSETPGT(SEQ ID NO: 429) | RSC-0095 | GTAEAASASGGGTGGAQNLVRGGPAPGSP(SEQ ID NO: 677) |
RSN-0096 | GSAPGEAGGAENLVRGGSIATSGSETPGT(SEQ ID NO: 430) | RSC-0096 | GTAEAASASGGEAGGAENLVRGGSIPGSP(SEQ ID NO: 678) |
RSN-1517 | GSAPEAGRSANHEPLGLVATATSGSETPGT(SEQ ID NO: 431) | RSC-1517 | GTAEAASASGEAGRSANHEPLGLVATPGSP(SEQ ID NO: 679) |
BSRS-A1-2 | GSAPASGRSTNAGPSGLAGPATSGSETPGT(SEQ ID NO: 432) | BSRS-A1-3 | GTAEAASASGASGRSTNAGPSGLAGPPGSP(SEQ ID NO: 680) |
BSRS-A2-2 | GSAPASGRSTNAGPQGLAGQATSGSETPGT(SEQ ID NO: 433) | BSRS-A2-3 | GTAEAASASGASGRSTNAGPQGLAGQPGSP(SEQ ID NO: 681) |
BSRS-A3-3 | GSAPASGRSTNAGPPGLTGPATSGSETPGT(SEQ ID NO: 434) | BSRS-A3-3 | GTAEAASASGASGRSTNAGPPGLTGPPGSP(SEQ ID NO: 682) |
VP-1 | GSAPASSRGTNAGPAGLTGPATSGSETPGT(SEQ ID NO: 435) | VP-1 | GTAEAASASGASSRGTNAGPAGLTGPPGSP(SEQ ID NO: 683) |
RSN-1752 | GSAPASSRTTNTGPSTLTGPATSGSETPGT(SEQ ID NO: 436) | RSC-1752 | GTAEAASASGASSRTTNTGPSTLTGPPGSP(SEQ ID NO: 684) |
RSN-1512 | GSAPAAGRSDNGTPLELVAPATSGSETPGT(SEQ ID NO: 437) | RSC-1512 | GTAEAASASGAAGRSDNGTPLELVAPPGSP(SEQ ID NO: 685) |
RSN-1517 | GSAPEAGRSANHEPLGLVATATSGSETPGT(SEQ ID NO: 438) | RSC-1517 | GTAEAASASGEAGRSANHEPLGLVATPGSP(SEQ ID NO: 686) |
VP-2 | GSAPASGRGTNAGPAGLTGPATSGSETPGT(SEQ ID NO: 439) | VP-2 | GTAEAASASGASGRGTNAGPAGLTGPPGSP(SEQ ID NO: 687) |
RSN-1018 | GSAPLFGRNDNHEPLELGGGATSGSETPGT(SEQ ID NO: 440) | RSC-1018 | GTAEAASASGLFGRNDNHEPLELGGGPGSP(SEQ ID NO: 688) |
RSN-1053 | GSAPTAGRSDNLEPLGLVFGATSGSETPGT(SEQ ID NO: 441) | RSC-1053 | GTAEAASASGTAGRSDNLEPLGLVFGPGSP(SEQ ID NO: 689) |
RSN-1059 | GSAPLDGRSDNFHPPELVAGATSGSETPGT(SEQ ID NO: 442) | RSC-1059 | GTAEAASASGLDGRSDNFHPPELVAGPGSP(SEQ ID NO: 690) |
RSN-1065 | GSAPLEGRSDNEEPENLVAGATSGSETPGT(SEQ ID NO: 443) | RSC-1065 | GTAEAASASGLEGRSDNEEPENLVAGPGSP(SEQ ID NO: 691) |
RSN-1167 | GSAPLKGRSDNNAPLALVAGATSGSETPGT(SEQ ID NO: 444) | RSC-1167 | GTAEAASASGLKGRSDNNAPLALVAGPGSP(SEQ ID NO: 692) |
RSN-1201 | GSAPVYSRGTNAGPHGLTGRATSGSETPGT(SEQ ID NO: 445) | RSC-1201 | GTAEAASASGVYSRGTNAGPHGLTGRPGSP(SEQ ID NO: 693) |
RSN-1218 | GSAPANSRGTNKGFAGLIGPATSGSETPGT(SEQ ID NO: 446) | RSC-1218 | GTAEAASASGANSRGTNKGFAGLIGPPGSP(SEQ ID NO: 694) |
RSN-1226 | GSAPASSRLTNEAPAGLTIPATSGSETPGT(SEQ ID NO: 447) | RSC-1226 | GTAEAASASGASSRLTNEAPAGLTIPPGSP(SEQ ID NO: 695) |
RSN-1254 | GSAPDQSRGTNAGPEGLTDPATSGSETPGT(SEQ ID NO: 448) | RSC-1254 | GTAEAASASGDQSRGTNAGPEGLTDPPGSP(SEQ ID NO: 696) |
RSN-1256 | GSAPESSRGTNIGQGGLTGPATSGSETPGT(SEQ ID NO: 449) | RSC-1256 | GTAEAASASGESSRGTNIGQGGLTGPPGSP(SEQ ID NO: 697) |
RSN-1261 | GSAPSSSRGTNQDPAGLTIPATSGSETPGT(SEQ ID NO: 450) | RSC-1261 | GTAEAASASGSSSRGTNQDPAGLTIPPGSP(SEQ ID NO: 698) |
RSN-1293 | GSAPASSRGQNHSPMGLTGPATSGSETPGT(SEQ ID NO: 451) | RSC-1293 | GTAEAASASGASSRGQNHSPMGLTGPPGSP(SEQ ID NO: 699) |
RSN-1309 | GSAPAYSRGPNAGPAGLEGRATSGSETPGT(SEQ ID NO: 452) | RSC-1309 | GTAEAASASGAYSRGPNAGPAGLEGRPGSP(SEQ ID NO: 700) |
RSN-1326 | GSAPASERGNNAGPANLTGFATSGSETPGT(SEQ ID NO: 453) | RSC-1326 | GTAEAASASGASERGNNAGPANLTGFPGSP(SEQ ID NO: 701) |
RSN-1345 | GSAPASHRGTNPKPAILTGPATSGSETPGT(SEQ ID NO: 454) | RSC-1345 | GTAEAASASGASHRGTNPKPAILTGPPGSP(SEQ ID NO: 702) |
RSN-1354 | GSAPMSSRRTNANPAQLTGPATSGSETPGT(SEQ ID NO: 455) | RSC-1354 | GTAEAASASGMSSRRTNANPAQLTGPPGSP(SEQ ID NO: 703) |
RSN-1426 | GSAPGAGRTDNHEPLELGAAATSGSETPGT(SEQ ID NO: 456) | RSC-1426 | GTAEAASASGGAGRTDNHEPLELGAAPGSP(SEQ ID NO: 704) |
RSN-1478 | GSAPLAGRSENTAPLELTAGATSGSETPGT(SEQ ID NO: 457) | RSC-1478 | GTAEAASASGLAGRSENTAPLELTAGPGSP(SEQ ID NO: 705) |
RSN-1479 | GSAPLEGRPDNHEPLALVASATSGSETPGT(SEQ ID NO: 458) | RSC-1479 | GTAEAASASGLEGRPDNHEPLALVASPGSP(SEQ ID NO: 706) |
RSN-1496 | GSAPLSGRSDNEEPLALPAGATSGSETPGT(SEQ ID NO: 459) | RSC-1496 | GTAEAASASGLSGRSDNEEPLALPAGPGSP(SEQ ID NO: 707) |
RSN-1508 | GSAPEAGRTDNHEPLELSAPATSGSETPGT(SEQ ID NO: 460) | RSC-1508 | GTAEAASASGEAGRTDNHEPLELSAPPGSP(SEQ ID NO: 708) |
RSN-1513 | GSAPEGGRSDNHGPLELVSGATSGSETPGT(SEQ ID NO: 461) | RSC-1513 | GTAEAASASGEGGRSDNHGPLELVSGPGSP(SEQ ID NO: 709) |
RSN-1516 | GSAPLSGRSDNEAPLELEAGATSGSETPGT(SEQ ID NO: 462) | RSC-1516 | GTAEAASASGLSGRSDNEAPLELEAGPGSP(SEQ ID NO: 710) |
RSN-1524 | GSAPLGGRADNHEPPELGAGATSGSETPGT(SEQ ID NO: 463) | RSC-1524 | GTAEAASASGLGGRADNHEPPELGAGPGSP(SEQ ID NO: 711) |
RSN-1622 | GSAPPPSRGTNAEPAGLTGEATSGSETPGT(SEQ ID NO: 464) | RSC-1622 | GTAEAASASGPPSRGTNAEPAGLTGEPGSP(SEQ ID NO: 712) |
RSN-1629 | GSAPASTRGENAGPAGLEAPATSGSETPGT(SEQ ID NO: 465) | RSC-1629 | GTAEAASASGASTRGENAGPAGLEAPPGSP(SEQ ID NO: 713) |
RSN-1664 | GSAPESSRGTNGAPEGLTGPATSGSETPGT(SEQ ID NO: 466) | RSC-1664 | GTAEAASASGESSRGTNGAPEGLTGPPGSP(SEQ ID NO: 714) |
RSN-1667 | GSAPASSRATNESPAGLTGEATSGSETPGT(SEQ ID NO: 467) | RSC-1667 | GTAEAASASGASSRATNESPAGLTGEPGSP(SEQ ID NO: 715) |
RSN-1709 | GSAPASSRGENPPPGGLTGPATSGSETPGT(SEQ ID NO: 468) | RSC-1709 | GTAEAASASGASSRGENPPPGGLTGPPGSP(SEQ ID NO: 716) |
RSN-1712 | GSAPAASRGTNTGPAELTGSATSGSETPGT(SEQ ID NO: 469) | RSC-1712 | GTAEAASASGAASRGTNTGPAELTGSPGSP(SEQ ID NO: 717) |
RSN-1727 | GSAPAGSRTTNAGPGGLEGPATSGSETPGT(SEQ ID NO: 470) | RSC-1727 | GTAEAASASGAGSRTTNAGPGGLEGPPGSP(SEQ ID NO: 718) |
RSN-1754 | GSAPAPSRGENAGPATLTGAATSGSETPGT(SEQ ID NO: 471) | RSC-1754 | GTAEAASASGAPSRGENAGPATLTGAPGSP(SEQ ID NO: 719) |
RSN-1819 | GSAPESGRAANTGPPTLTAPATSGSETPGT(SEQ ID NO: 472) | RSC-1819 | GTAEAASASGESGRAANTGPPTLTAPPGSP(SEQ ID NO: 720) |
RSN-1832 | GSAPNPGRAANEGPPGLPGSATSGSETPGT(SEQ ID NO: 473) | RSC-1832 | GTAEAASASGNPGRAANEGPPGLPGSPGSP(SEQ ID NO: 721) |
RSN-1855 | GSAPESSRAANLTPPELTGPATSGSETPGT(SEQ ID NO: 474) | RSC-1855 | GTAEAASASGESSRAANLTPPELTGPPGSP(SEQ ID NO: 722) |
RSN-1911 | GSAPASGRAANETPPGLTGAATSGSETPGT(SEQ ID NO: 475) | RSC-1911 | GTAEAASASGASGRAANETPPGLTGAPGSP(SEQ ID NO: 723) |
RSN-1929 | GSAPNSGRGENLGAPGLTGTATSGSETPGT(SEQ ID NO: 476) | RSC-1929 | GTAEAASASGNSGRGENLGAPGLTGTPGSP(SEQ ID NO: 724) |
RSN-1951 | GSAPTTGRAANLTPAGLTGPATSGSETPGT(SEQ ID NO: 477) | RSC-1951 | GTAEAASASGTTGRAANLTPAGLTGPPGSP(SEQ ID NO: 725) |
RSN-2295 | GSAPEAGRSANHTPAGLTGPATSGSETPGT(SEQ ID NO: 478) | RSC-2295 | GTAEAASASGEAGRSANHTPAGLTGPPGSP(SEQ ID NO: 726) |
RSN-2298 | GSAPESGRAANTTPAGLTGPATSGSETPGT(SEQ ID NO: 479) | RSC-2298 | GTAEAASASGESGRAANTTPAGLTGPPGSP(SEQ ID NO: 727) |
RSN-2038 | GSAPTTGRATEAANLTPAGLTGPATSGSETPGT(SEQ ID NO: 480) | RSC-2038 | GTAEAASASGTTGRATEAANLTPAGLTGPPGSP(SEQ ID NO: 728) |
RSN-2072 | GSAPTTGRAEEAANLTPAGLTGPATSGSETPGT(SEQ ID NO: 481) | RSC-2072 | GTAEAASASGTTGRAEEAANLTPAGLTGPPGSP(SEQ ID NO: 729) |
RSN-2089 | GSAPTTGRAGEAANLTPAGLTGPATSGSETPGT(SEQ ID NO: 482) | RSC-2089 | GTAEAASASGTTGRAGEAANLTPAGLTGPPGSP(SEQ ID NO: 730) |
RSN-2302 | GSAPTTGRATEAANATPAGLTGPATSGSETPGT(SEQ ID NO: 483) | RSC-2302 | GTAEAASASGTTGRATEAANATPAGLTGPPGSP(SEQ ID NO: 731) |
RSN-3047 | GSAPTTGRAGEAEGATSAGATGPATSGSETPGT(SEQ ID NO: 484) | RSC-3047 | GTAEAASASGTTGRAGEAEGATSAGATGPPGSP(SEQ ID NO: 732) |
RSN-3052 | GSAPTTGEAGEAANATSAGATGPATSGSETPGT(SEQ ID NO: 485) | RSC-3052 | GTAEAASASGTTGEAGEAANATSAGATGPPGSP(SEQ ID NO: 733) |
RSN-3043 | GSAPTTGEAGEAAGLTPAGLTGPATSGSETPGT(SEQ ID NO: 486) | RSC-3043 | GTAEAASASGTTGEAGEAAGLTPAGLTGPPGSP(SEQ ID NO: 734) |
RSN-3041 | GSAPTTGAAGEAANATPAGLTGPATSGSETPGT(SEQ ID NO: 487) | RSC-3041 | GTAEAASASGTTGAAGEAANATPAGLTGPPGSP(SEQ ID NO: 735) |
RSN-3044 | GSAPTTGRAGEAAGLTPAGLTGPATSGSETPGT(SEQ ID NO: 488) | RSC-3044 | GTAEAASASGTTGRAGEAAGLTPAGLTGPPGSP(SEQ ID NO: 736) |
RSN-3057 | GSAPTTGRAGEAANATSAGATGPATSGSETPGT(SEQ ID NO: 489) | RSC-3057 | GTAEAASASGTTGRAGEAANATSAGATGPPGSP(SEQ ID NO: 737) |
RSN-3058 | GSAPTTGEAGEAAGATSAGATGPATSGSETPGT(SEQ ID NO: 490) | RSC-3058 | GTAEAASASGTTGEAGEAAGATSAGATGPPGSP(SEQ ID NO: 738) |
RSN-2485 | GSAPESGRAANTEPPELGAGATSGSETPGT(SEQ ID NO: 491) | RSC-2485 | GTAEAASASGESGRAANTEPPELGAGPGSP(SEQ ID NO: 739) |
RSN-2486 | GSAPESGRAANTAPEGLTGPATSGSETPGT(SEQ ID NO: 492) | RSC-2486 | GTAEAASASGESGRAANTAPEGLTGPPGSP(SEQ ID NO: 740) |
RSN-2488 | GSAPEPGRAANHEPSGLTEGATSGSETPGT(SEQ ID NO: 493) | RSC-2488 | GTAEAASASGEPGRAANHEPSGLTEGPGSP(SEQ ID NO: 741) |
RSN-2599 | GSAPESGRAANHTGAPPGGLTGPATSGSETPGT(SEQ ID NO: 494) | RSC-2599 | GTAEAASASGESGRAANHTGAPPGGLTGPPGSP(SEQ ID NO: 742) |
RSN-2706 | GSAPTTGRTGEGANATPGGLTGPATSGSETPGT(SEQ ID NO: 495) | RSC-2706 | GTAEAASASGTTGRTGEGANATPGGLTGPPGSP(SEQ ID NO: 743) |
RSN-2707 | GSAPRTGRSGEAANETPEGLEGPATSGSETPGT(SEQ ID NO: 496) | RSC-2707 | GTAEAASASGRTGRSGEAANETPEGLEGPPGSP(SEQ ID NO: 744) |
RSN-2708 | GSAPRTGRTGESANETPAGLGGPATSGSETPGT(SEQ ID NO: 497) | RSC-2708 | GTAEAASASGRTGRTGESANETPAGLGGPPGSP(SEQ ID NO: 745) |
RSN-2709 | GSAPSTGRTGEPANETPAGLSGPATSGSETPGT(SEQ ID NO: 498) | RSC-2709 | GTAEAASASGSTGRTGEPANETPAGLSGPPGSP(SEQ ID NO: 746) |
RSN-2710 | GSAPTTGRAGEPANATPTGLSGPATSGSETPGT(SEQ ID NO: 499) | RSC-2710 | GTAEAASASGTTGRAGEPANATPTGLSGPPGSP(SEQ ID NO: 747) |
RSN-2711 | GSAPRTGRPGEGANATPTGLPGPATSGSETPGT(SEQ ID NO: 500) | RSC-2711 | GTAEAASASGRTGRPGEGANATPTGLPGPPGSP(SEQ ID NO: 748) |
RSN-2712 | GSAPRTGRGGEAANATPSGLGGPATSGSETPGT(SEQ ID NO: 501) | RSC-2712 | GTAEAASASGRTGRGGEAANATPSGLGGPPGSP(SEQ ID NO: 749) |
RSN-2713 | GSAPSTGRSGESANATPGGLGGPATSGSETPGT(SEQ ID NO: 502) | RSC-2713 | GTAEAASASGSTGRSGESANATPGGLGGPPGSP(SEQ ID NO: 750) |
RSN-2714 | GSAPRTGRTGEEANATPAGLPGPATSGSETPGT(SEQ ID NO: 503) | RSC-2714 | GTAEAASASGRTGRTGEEANATPAGLPGPPGSP(SEQ ID NO: 751) |
RSN-2715 | GSAPATGRPGEPANTTPEGLEGPATSGSETPGT(SEQ ID NO: 504) | RSC-2715 | GTAEAASASGATGRPGEPANTTPEGLEGPPGSP(SEQ ID NO: 752) |
RSN-2716 | GSAPSTGRSGEPANATPGGLTGPATSGSETPGT(SEQ ID NO: 505) | RSC-2716 | GTAEAASASGSTGRSGEPANATPGGLTGPPGSP(SEQ ID NO: 753) |
RSN-2717 | GSAPPTGRGGEGANTTPTGLPGPATSGSETPGT(SEQ ID NO: 506) | RSC-2717 | GTAEAASASGPTGRGGEGANTTPTGLPGPPGSP(SEQ ID NO: 754) |
RSN-2718 | GSAPPTGRSGEGANATPSGLTGPATSGSETPGT(SEQ ID NO: 507) | RSC-2718 | GTAEAASASGPTGRSGEGANATPSGLTGPPGSP(SEQ ID NO: 755) |
RSN-2719 | GSAPTTGRASEGANSTPAPLTEPATSGSETPGT(SEQ ID NO: 508) | RSC-2719 | GTAEAASASGTTGRASEGANSTPAPLTEPPGSP(SEQ ID NO: 756) |
RSN-2720 | GSAPTYGRAAEAANTTPAGLTAPATSGSETPGT(SEQ ID NO: 509) | RSC-2720 | GTAEAASASGTYGRAAEAANTTPAGLTAPPGSP(SEQ ID NO: 757) |
RSN-2721 | GSAPTTGRATEGANATPAELTEPATSGSETPGT(SEQ ID NO: 510) | RSC-2721 | GTAEAASASGTTGRATEGANATPAELTEPPGSP(SEQ ID NO: 758) |
RSN-2722 | GSAPTVGRASEEANTTPASLTGPATSGSETPGT(SEQ ID NO: 511) | RSC-2722 | GTAEAASASGTVGRASEEANTTPASLTGPPGSP(SEQ ID NO: 759) |
RSN-2723 | GSAPTTGRAPEAANATPAPLTGPATSGSETPGT(SEQ ID NO: 512) | RSC-2723 | GTAEAASASGTTGRAPEAANATPAPLTGPPGSP(SEQ ID NO: 760) |
RSN-2724 | GSAPTWGRATEPANATPAPLTSPATSGSETPGT(SEQ ID NO: 513) | RSC-2724 | GTAEAASASGTWGRATEPANATPAPLTSPPGSP(SEQ ID NO: 761) |
RSN-2725 | GSAPTVGRASESANATPAELTSPATSGSETPGT(SEQ ID NO: 514) | RSC-2725 | GTAEAASASGTVGRASESANATPAELTSPPGSP(SEQ ID NO: 762) |
RSN-2726 | GSAPTVGRAPEGANSTPAGLTGPATSGSETPGT(SEQ ID NO: 515) | RSC-2726 | GTAEAASASGTVGRAPEGANSTPAGLTGPPGSP(SEQ ID NO: 763) |
RSN-2727 | GSAPTWGRATEAPNLEPATLTTPATSGSETPGT(SEQ ID NO: 516) | RSC-2727 | GTAEAASASGTWGRATEAPNLEPATLTTPPGSP(SEQ ID NO: 764) |
RSN-2728 | GSAPTTGRATEAPNLTPAPLTEPATSGSETPGT(SEQ ID NO: 517) | RSC-2728 | GTAEAASASGTTGRATEAPNLTPAPLTEPPGSP(SEQ ID NO: 765) |
RSN-2729 | GSAPTQGRATEAPNLSPAALTSPATSGSETPGT(SEQ ID NO: 518) | RSC-2729 | GTAEAASASGTQGRATEAPNLSPAALTSPPGSP(SEQ ID NO: 766) |
RSN-2730 | GSAPTQGRAAEAPNLTPATLTAPATSGSETPGT(SEQ ID NO: 519) | RSC-2730 | GTAEAASASGTQGRAAEAPNLTPATLTAPPGSP(SEQ ID NO: 767) |
RSN-2731 | GSAPTSGRAPEATNLAPAPLTGPATSGSETPGT(SEQ ID NO: 520) | RSC-2731 | GTAEAASASGTSGRAPEATNLAPAPLTGPPGSP(SEQ ID NO: 768) |
RSN-2732 | GSAPTQGRAAEAANLTPAGLTEPATSGSETPGT(SEQ ID NO: 521) | RSC-2732 | GTAEAASASGTQGRAAEAANLTPAGLTEPPGSP(SEQ ID NO: 769) |
RSN-2733 | GSAPTTGRAGSAPNLPPTGLTTPATSGSETPGT(SEQ ID NO: 522) | RSC-2733 | GTAEAASASGTTGRAGSAPNLPPTGLTTPPGSP(SEQ ID NO: 770) |
RSN-2734 | GSAPTTGRAGGAENLPPEGLTAPATSGSETPGT(SEQ ID NO: 523) | RSC-2734 | GTAEAASASGTTGRAGGAENLPPEGLTAPPGSP(SEQ ID NO: 771) |
RSN-2735 | GSAPTTSRAGTATNLTPEGLTAPATSGSETPGT(SEQ ID NO: 524) | RSC-2735 | GTAEAASASGTTSRAGTATNLTPEGLTAPPGSP(SEQ ID NO: 772) |
RSN-2736 | GSAPTTGRAGTATNLPPSGLTTPATSGSETPGT(SEQ ID NO: 525) | RSC-2736 | GTAEAASASGTTGRAGTATNLPPSGLTTPPGSP(SEQ ID NO: 773) |
RSN-2737 | GSAPTTARAGEAENLSPSGLTAPATSGSETPGT(SEQ ID NO: 526) | RSC-2737 | GTAEAASASGTTARAGEAENLSPSGLTAPPGSP(SEQ ID NO: 774) |
RSN-2738 | GSAPTTGRAGGAGNLAPGGLTEPATSGSETPGT(SEQ ID NO: 527) | RSC-2738 | GTAEAASASGTTGRAGGAGNLAPGGLTEPPGSP(SEQ ID NO: 775) |
RSN-2739 | GSAPTTGRAGTATNLPPEGLTGPATSGSETPGT(SEQ ID NO: 528) | RSC-2739 | GTAEAASASGTTGRAGTATNLPPEGLTGPPGSP(SEQ ID NO: 776) |
RSN-2740 | GSAPTTGRAGGAANLAPTGLTEPATSGSETPGT(SEQ ID NO: 529) | RSC-2740 | GTAEAASASGTTGRAGGAANLAPTGLTEPPGSP(SEQ ID NO: 777) |
RSN-2741 | GSAPTTGRAGTAENLAPSGLTTPATSGSETPGT(SEQ ID NO: 530) | RSC-2741 | GTAEAASASGTTGRAGTAENLAPSGLTTPPGSP(SEQ ID NO: 778) |
RSN-2742 | GSAPTTGRAGSATNLGPGGLTGPATSGSETPGT(SEQ ID NO: 531) | RSC-2742 | GTAEAASASGTTGRAGSATNLGPGGLTGPPGSP(SEQ ID NO: 779) |
RSN-2743 | GSAPTTARAGGAENLTPAGLTEPATSGSETPGT(SEQ ID NO: 532) | RSC-2743 | GTAEAASASGTTARAGGAENLTPAGLTEPPGSP(SEQ ID NO: 780) |
RSN-2744 | GSAPTTARAGSAENLSPSGLTGPATSGSETPGT(SEQ ID NO: 533) | RSC-2744 | GTAEAASASGTTARAGSAENLSPSGLTGPPGSP(SEQ ID NO: 781) |
RSN-2745 | GSAPTTARAGGAGNLAPEGLTTPATSGSETPGT(SEQ ID NO: 534) | RSC-2745 | GTAEAASASGTTARAGGAGNLAPEGLTTPPGSP(SEQ ID NO: 782) |
RSN-2746 | GSAPTTSRAGAAENLTPTGLTGPATSGSETPGT(SEQ ID NO: 535) | RSC-2746 | GTAEAASASGTTSRAGAAENLTPTGLTGPPGSP(SEQ ID NO: 783) |
RSN-2747 | GSAPTYGRTTTPGNEPPASLEAEATSGSETPGT(SEQ ID NO: 536) | RSC-2747 | GTAEAASASGTYGRTTTPGNEPPASLEAEPGSP(SEQ ID NO: 784) |
RSN-2748 | GSAPTYSRGESGPNEPPPGLTGPATSGSETPGT(SEQ ID NO: 537) | RSC-2748 | GTAEAASASGTYSRGESGPNEPPPGLTGPPGSP(SEQ ID NO: 785) |
RSN-2749 | GSAPAWGRTGASENETPAPLGGEATSGSETPGT(SEQ ID NO: 538) | RSC-2749 | GTAEAASASGAWGRTGASENETPAPLGGEPGSP(SEQ ID NO: 786) |
RSN-2750 | GSAPRWGRAETTPNTPPEGLETEATSGSETPGT(SEQ ID NO: 539) | RSC-2750 | GTAEAASASGRWGRAETTPNTPPEGLETEPGSP(SEQ ID NO: 787) |
RSN-2751 | GSAPESGRAANHTGAEPPELGAGATSGSETPGT(SEQ ID NO: 540) | RSC-2751 | GTAEAASASGESGRAANHTGAEPPELGAGPGSP(SEQ ID NO: 788) |
RSN-2754 | GSAPTTGRAGEAANLTPAGLTESATSGSETPGT(SEQ ID NO: 541) | RSC-2754 | GTAEAASASGTTGRAGEAANLTPAGLTESPGSP(SEQ ID NO: 789) |
RSN-2755 | GSAPTTGRAGEAANLTPAALTESATSGSETPGT(SEQ ID NO: 542) | RSC-2755 | GTAEAASASGTTGRAGEAANLTPAALTESPGSP(SEQ ID NO: 790) |
RSN-2756 | GSAPTTGRAGEAANLTPAPLTESATSGSETPGT(SEQ ID NO: 543) | RSC-2756 | GTAEAASASGTTGRAGEAANLTPAPLTESPGSP(SEQ ID NO: 791) |
RSN-2757 | GSAPTTGRAGEAANLTPEPLTESATSGSETPGT(SEQ ID NO: 544) | RSC-2757 | GTAEAASASGTTGRAGEAANLTPEPLTESPGSP(SEQ ID NO: 792) |
RSN-2758 | GSAPTTGRAGEAANLTPAGLTGAATSGSETPGT(SEQ ID NO: 545) | RSC-2758 | GTAEAASASGTTGRAGEAANLTPAGLTGAPGSP(SEQ ID NO: 793) |
RSN-2759 | GSAPTTGRAGEAANLTPEGLTGAATSGSETPGT(SEQ ID NO: 546) | RSC-2759 | GTAEAASASGTTGRAGEAANLTPEGLTGAPGSP(SEQ ID NO: 794) |
RSN-2760 | GSAPTTGRAGEAANLTPEPLTGAATSGSETPGT(SEQ ID NO: 547) | RSC-2760 | GTAEAASASGTTGRAGEAANLTPEPLTGAPGSP(SEQ ID NO: 795) |
RSN-2761 | GSAPTTGRAGEAANLTPAGLTEAATSGSETPGT(SEQ ID NO: 548) | RSC-2761 | GTAEAASASGTTGRAGEAANLTPAGLTEAPGSP(SEQ ID NO: 796) |
RSN-2762 | GSAPTTGRAGEAANLTPEGLTEAATSGSETPGT(SEQ ID NO: 549) | RSC-2762 | GTAEAASASGTTGRAGEAANLTPEGLTEAPGSP(SEQ ID NO: 797) |
RSN-2763 | GSAPTTGRAGEAANLTPAPLTEAATSGSETPGT(SEQ ID NO: 550) | RSC-2763 | GTAEAASASGTTGRAGEAANLTPAPLTEAPGSP(SEQ ID NO: 798) |
RSN-2764 | GSAPTTGRAGEAANLTPEPLTEAATSGSETPGT(SEQ ID NO: 551) | RSC-2764 | GTAEAASASGTTGRAGEAANLTPEPLTEAPGSP(SEQ ID NO: 799) |
RSN-2765 | GSAPTTGRAGEAANLTPEPLTGPATSGSETPGT(SEQ ID NO: 552) | RSC-2765 | GTAEAASASGTTGRAGEAANLTPEPLTGPPGSP(SEQ ID NO: 800) |
RSN-2766 | GSAPTTGRAGEAANLTPAGLTGGATSGSETPGT(SEQ ID NO: 553) | RSC-2766 | GTAEAASASGTTGRAGEAANLTPAGLTGGPGSP(SEQ ID NO: 801) |
RSN-2767 | GSAPTTGRAGEAANLTPEGLTGGATSGSETPGT(SEQ ID NO: 554) | RSC-2767 | GTAEAASASGTTGRAGEAANLTPEGLTGGPGSP(SEQ ID NO: 802) |
RSN-2768 | GSAPTTGRAGEAANLTPEALTGGATSGSETPGT(SEQ ID NO: 555) | RSC-2768 | GTAEAASASGTTGRAGEAANLTPEALTGGPGSP(SEQ ID NO: 803) |
RSN-2769 | GSAPTTGRAGEAANLTPEPLTGGATSGSETPGT(SEQ ID NO: 556) | RSC-2769 | GTAEAASASGTTGRAGEAANLTPEPLTGGPGSP(SEQ ID NO: 804) |
RSN-2770 | GSAPTTGRAGEAANLTPAGLTEGATSGSETPGT(SEQ ID NO: 557) | RSC-2770 | GTAEAASASGTTGRAGEAANLTPAGLTEGPGSP(SEQ ID NO: 805) |
RSN-2771 | GSAPTTGRAGEAANLTPEGLTEGATSGSETPGT(SEQ ID NO: 558) | RSC-2771 | GTAEAASASGTTGRAGEAANLTPEGLTEGPGSP(SEQ ID NO: 806) |
RSN-2772 | GSAPTTGRAGEAANLTPAPLTEGATSGSETPGT(SEQ ID NO: 559) | RSC-2772 | GTAEAASASGTTGRAGEAANLTPAPLTEGPGSP(SEQ ID NO: 807) |
RSN-2773 | GSAPTTGRAGEAANLTPEPLTEGATSGSETPGT(SEQ ID NO: 560) | RSC-2773 | GTAEAASASGTTGRAGEAANLTPEPLTEGPGSP(SEQ ID NO: 808) |
RSN-3047 | GSAPTTGRAGEAEGATSAGATGPATSGSETPGT(SEQ ID NO: 561) | RSC-3047 | GTAEAASASGTTGRAGEAEGATSAGATGPPGSP(SEQ ID NO: 809) |
RSN-2783 | GSAPEAGRSAEATSAGATGPATSGSETPGT(SEQ ID NO: 562) | RSC-2783 | GTAEAASASGEAGRSAEATSAGATGPPGSP(SEQ ID NO: 810) |
RSN-3107 | GSAPSASGTYSRGESGPGSPATSGSETPGT(SEQ ID NO: 563) | RSC-3107 | GTAEAASASGSASGTYSRGESGPGSPPGSP(SEQ ID NO: 811) |
RSN-3103 | GSAPSASGEAGRTDTHPGSPATSGSETPGT(SEQ ID NO: 564) | RSC-3103 | GTAEAASASGSASGEAGRTDTHPGSPPGSP(SEQ ID NO: 812) |
RSN-3102 | GSAPSASGEPGRAAEHPGSPATSGSETPGT(SEQ ID NO: 565) | RSC-3102 | GTAEAASASGSASGEPGRAAEHPGSPPGSP(SEQ ID NO: 813) |
RSN-3119 | GSAPSPAGESSRGTTIAGSPATSGSETPGT(SEQ ID NO: 566) | RSC-3119 | GTAEAASASGSPAGESSRGTTIAGSPPGSP(SEQ ID NO: 814) |
RSN-3043 | GSAPTTGEAGEAAGLTPAGLTGPATSGSETPGT(SEQ ID NO: 567) | RSC-3043 | GTAEAASASGTTGEAGEAAGLTPAGLTGPPGSP(SEQ ID NO: 815) |
RSN-2789 | GSAPEAGESAGATPAGLTGPATSGSETPGT(SEQ ID NO: 568) | RSC-2789 | GTAEAASASGEAGESAGATPAGLTGPPGSP(SEQ ID NO: 816) |
RSN-3109 | GSAPSASGAPLELEAGPGSPATSGSETPGT(SEQ ID NO: 569) | RSC-3109 | GTAEAASASGSASGAPLELEAGPGSPPGSP(SEQ ID NO: 817) |
RSN-3110 | GSAPSASGEPPELGAGPGSPATSGSETPGT(SEQ ID NO: 570) | RSC-3110 | GTAEAASASGSASGEPPELGAGPGSPPGSP(SEQ ID NO: 818) |
RSN-3111 | GSAPSASGEPSGLTEGPGSPATSGSETPGT(SEQ ID NO: 571) | RSC-3111 | GTAEAASASGSASGEPSGLTEGPGSPPGSP(SEQ ID NO: 819) |
RSN-3112 | GSAPSASGTPAPLTEPPGSPATSGSETPGT(SEQ ID NO: 572) | RSC-3112 | GTAEAASASGSASGTPAPLTEPPGSPPGSP(SEQ ID NO: 820) |
RSN-3113 | GSAPSASGTPAELTEPPGSPATSGSETPGT(SEQ ID NO: 573) | RSC-3113 | GTAEAASASGSASGTPAELTEPPGSPPGSP(SEQ ID NO: 821) |
RSN-3114 | GSAPSASGPPPGLTGPPGSPATSGSETPGT(SEQ ID NO: 574) | RSC-3114 | GTAEAASASGSASGPPPGLTGPPGSPPGSP(SEQ ID NO: 822) |
RSN-3115 | GSAPSASGTPAPLGGEPGSPATSGSETPGT(SEQ ID NO: 575) | RSC-3115 | GTAEAASASGSASGTPAPLGGEPGSPPGSP(SEQ ID NO: 823) |
RSN-3125 | GSAPSPAGAPEGLTGPAGSPATSGSETPGT(SEQ ID NO: 576) | RSC-3125 | GTAEAASASGSPAGAPEGLTGPAGSPPGSP(SEQ ID NO: 824) |
RSN-3126 | GSAPSPAGPPEGLETEAGSPATSGSETPGT(SEQ ID NO: 577) | RSC-3126 | GTAEAASASGSPAGPPEGLETEAGSPPGSP(SEQ ID NO: 825) |
RSN-3127 | GSAPSPTSGQGGLTGPGSEPATSGSETPGT(SEQ ID NO: 578) | RSC-3127 | GTAEAASASGSPTSGQGGLTGPGSEPPGSP(SEQ ID NO: 826) |
RSN-3131 | GSAPSESAPPEGLETESTEPATSGSETPGT(SEQ ID NO: 579) | RSC-3131 | GTAEAASASGSESAPPEGLETESTEPPGSP(SEQ ID NO: 827) |
RSN-3132 | GSAPSEGSEPLELGAASETPATSGSETPGT(SEQ ID NO: 580) | RSC-3132 | GTAEAASASGSEGSEPLELGAASETPPGSP(SEQ ID NO: 828) |
RSN-3133 | GSAPSEGSGPAGLEAPSETPATSGSETPGT(SEQ ID NO: 581) | RSC-3133 | GTAEAASASGSEGSGPAGLEAPSETPPGSP(SEQ ID NO: 829) |
RSN-3138 | GSAPSEPTPPASLEAEPGSPATSGSETPGT(SEQ ID NO: 582) | RSC-3138 | GTAEAASASGSEPTPPASLEAEPGSPPGSP(SEQ ID NO: 830) |
本揭示案之RS適用於包括於重組多肽中作為治療劑,用於治療癌症、自體免疫性疾病、發炎性疾病及其他需要重組多肽之局部活化的病況。本發明組合物解決未滿足之需求且相比於注射後具活性之習知抗體治療劑或雙特異性抗體治療劑,在一或多個態樣中優良,包括增強之終末半衰期、靶向遞送及改良之治療比與減少之健康組織毒性。
在一個實施例中,併入至BPXTEN融合蛋白之BP可具有序列,其展現與
表 3或
表 A之序列至少約80%序列一致性,或替代地與
表 3或
表 A之序列相比至少約81%、或約82%、或約83%、或約84%、或約85%、或約86%、或約87%、或約88%、或約89%、或約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%或約100%序列一致性。可使用如本文所描述之分析或經量測或經測定的參數評估前述實施例之BP,且相比於對應天然BP序列保持至少約40%、或約50%、或約55%、或約60%、或約70%、或約80%、或約90%、或約95%或更大活性之彼等序列將視為適合於包涵於本發明BPXTEN中。發現保留適合活性水準之BP可連接至上文所描述之一或多個XTEN多肽。在一個實施例中,發現保留適合水準之活性的BP可連接至一或多個XTEN多肽,該XTEN多肽具有與
表 2 a- 2 b之序列至少約80%序列一致性,或替代地與
表 2 a- 2 b之序列相比至少約81%、82%、83%、84%、85%、86%、87%、88%、89%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或約100%序列一致性,得到嵌合融合蛋白。
本揭示案涵蓋選自
表 3或
表 A且連接至一個或兩個XTEN之其他BP的取代,該等XTEN可相同或不同,選自
表 2 a- 2 b。在此段落中上文所描述之前述融合蛋白中,BPXTEN融合蛋白可進一步包含來自
表 5之裂解序列;裂解序列位於BP與XTEN之間或相鄰BP之間。在一些情況下,包含裂解序列之BPXTEN亦將在BP與裂解序列或XTEN與裂解序列之間具有一或多個間隔子序列胺基酸以促進蛋白酶之獲取;該等間隔子胺基酸包含任何天然胺基酸,包括甘胺酸及丙胺酸作為較佳胺基酸。
靶向部分
在某些實施例中,經考慮本發明之XPAC亦可進一步包含允許XPAC結合至在腫瘤上表現之抗原的腫瘤靶向部分。此可藉由包括嵌合多肽(XPAC)中之另一域以影響其在體內之移動來達成。舉例而言,嵌合核酸可以編碼將多肽引導至體內之位置(例如腫瘤細胞或發炎部位)的域。例示性及適合之靶向部分域包含具有在發炎組織中過度表現之同源配位體的彼等靶向部分域,例如IL-1受體或IL-6受體。在其他實施例中,適合之靶向部分包含具有在腫瘤組織中過度表現之同源配位體的彼等靶向部分,例如Epcam、CEA或間皮素。在一些實施例中,靶向域經由連接子連接至細胞介素,該連接子在作用部位(例如藉由發炎或癌症特異性蛋白酶)裂解,使得在所需位點處釋放細胞介素之完全活性。在一些實施例中,靶向及/或保留域經由未在作用部位裂解(例如藉由炎症或癌症特異性蛋白酶)之連接子連接至介白素,使得細胞介素保留在所需位點。
尤其較佳的靶向部分靶抗原表現在病變細胞或組織(例如腫瘤或癌細胞)之表面上。適用於腫瘤靶向及保留之抗原包括(但不限於)EpCAM、EGFR、HER-2、HER-3、c-Met、FOLR1及CEA。本文所揭示之醫藥組合物亦包括包含兩個靶向及/或保留域之蛋白質,該等靶向及/或保留域結合至已知在病變細胞或組織上表現之兩種不同靶抗原。例示性抗原結合域對包括(但不限於)EGFR/CEA、EpCAM/CEA及HER-2/HER-3。
適合之靶向部分包括抗原結合域,諸如抗體及其片段,包括多株抗體、重組抗體、人類抗體、人類化抗體、單鏈可變片段(scFv)、單域抗體(諸如重γ鏈可變域(VH)、輕鏈可變域(VL)及駱駝型奈米抗體之可變域(VHH))、dAb及其類似物。其他適合之抗原結合域包括模擬抗體結合及/或結構之非免疫球蛋白蛋白質,諸如抗運載蛋白、人類泛素(affilin)、親和抗體分子、親和體、親和素(affitin)、α體(alphabody)、(avimer)、DARPin、fynomer、kunitz域肽、單功能抗體及基於其他經工程改造之骨架(諸如SpA、GroEL、纖維結合蛋白、脂質運載蛋白及CTLA4骨架)的結合域。抗原結合多肽之其他實例包括所需受體之配位體、受體之配體結合部分、凝集素及結合於一或多種靶抗原或與一或多種靶抗原締合的肽。
在一些實施例中,靶向部分特異性結合至細胞表面分子。在一些實施例中,靶向及/或保留域特異性結合至腫瘤抗原。在一些實施例中,靶向多肽特異性且獨立地結合於選自以下中之至少一者的腫瘤抗原:纖維母細胞活化蛋白α(FAPa)、滋胚層醣蛋白(5T4)、腫瘤相關鈣信號轉導子2(Trop2)、纖維結合蛋白EDB(EDB-FN,參見美國公開案20200397915)、纖維結合蛋白EIIIB域、CGS-2、EpCAM、EGFR、HER-2、HER-3、cMet、CEA及FOLR1。在一些實施例中,靶向多肽特異性且獨立地結合至兩種不同抗原,其中該等抗原中之至少一者為選自EpCAM、EGFR、HER-2、HER-3、cMet、CEA及FOLR1之腫瘤抗原。
靶向抗原可為表現於腫瘤細胞上之腫瘤抗原。腫瘤抗原為此項技術中所熟知且包括例如EpCAM、EGFR、HER-2、HER-3、c-Met、FOLR1、PSMA、CD38、BCMA及CEA。5T4、AFP、B7-H3、鈣黏素-6、CAIX、CD117、CD123、CD138、CD166、CD19、CD20、CD205、CD22、CD30、CD33、CD352、CD37、CD44、CD52、CD56、CD70、CD71、CD74、CD79b、DLL3、EphA2、FAP、FGFR2、FGFR3、GPC3、gpA33、FLT-3、gpNMB、HPV-16 E6、HPV-16 E7、ITGA2、ITGA3、SLC39A6、MAGE、間皮素、Mucl、Muc16、NaPi2b、黏附分子-4、P-鈣黏素、NY-ESO-1、PRLR、PSCA、PTK7、ROR1、SLC44A4、SLTRK5、SLTRK6、STEAP1、TIM1、Trop2、WT1。
靶向抗原可為免疫檢查點蛋白。免疫檢查點蛋白質之實例包括(但不限於)CD27、CD137、2B4、TIGIT、CD155、ICOS、HVEM、CD40L、LIGHT、TIM-1、OX40、DNAM-1、PD-L1、PD1、PD-L2、CTLA-4、CD8、CD40、CEACAM1、CD48、CD70、A2AR、CD39、CD73、B7-H3、B7-H4、BTLA、IDO1、IDO2、TDO、KIR、LAG-3、TIM-3或VISTA。
靶向抗原可為細胞表面分子,諸如蛋白質、脂質或多醣。在一些實施例中,此類抗原為腫瘤細胞、病毒感染細胞、細菌感染細胞、受損紅血球、動脈斑塊細胞、發炎或纖維化組織細胞。此類抗原可包含免疫反應調節劑,諸如包括(但不限於)顆粒球-巨噬細胞群落刺激因子(GM-CSF)、巨噬細胞群落刺激因子(M-CSF)、顆粒球群落刺激因子(G-CSF)、介白素2(IL-2)、介白素3(IL-3)、介白素12(IL-12)、介白素15(IL-15)、B7-1(CD80)、B7-2(CD86)、GITRL、CD3或GITR。
BPXTEN之藥物動力學特性
本發明提供相比於不連接至XTEN之BP具有增強之藥物動力學的BPXTEN融合蛋白,當藉由本文所描述之方法測定以組合物之劑量使用時,可達成產生藥理學效應之循環濃度,相比於不連接至XTEN之BP的可比劑量,該組合物之生物活性組分在安全範圍內保持延長時段。在此類情況下,BPXTEN保持在融合蛋白組合物之治療窗內持續延長時段。如本文所使用,「可比劑量」意謂以可比方式向個體投與之活性BP藥效團的等效莫耳/公斤劑量。在此項技術中應理解,BPXTEN融合蛋白之「可比劑量」將表示更大重量之試劑,但在融合蛋白之劑量中將具有基本上相同的BP莫耳當量及/或相對於BP將具有相同的近似莫耳濃度。
可藉由將給定XTEN連接至BP來增強之BP的藥物動力學特性,包括終末半衰期、曲線下面積(AUC)、C
max分佈體積及生物可用性。
如關於包含XTEN之融合蛋白的藥物動力學特徵的實例中更充分地描述,出人意料地發現,增加XTEN序列之長度可賦予包含XTEN之融合蛋白的終末半衰期之不成比例增加。因此,本發明提供包含XTEN之BPXTEN融合蛋白,其中XTEN可經選擇以提供向個體投與之BPXTEN組合物的靶向半衰期。在一些實施例中,本發明提供包含XTEN之單體融合蛋白,其中相比於不連接至融合蛋白之相應BP,XTEN經選擇以賦予投與之BPXTEN的終末半衰期增加,且與不連接至融合蛋白之BP相比,終末半衰期增加至少約兩倍、或至少約三倍、或至少約四倍、或至少約五倍、或至少約六倍、或至少約七倍、或至少約八倍、或至少約九倍、或至少約十倍、或至少約15倍、或至少20倍或以上。類似地,BPXTEN融合蛋白可具有AUC增加,且與不連接至融合蛋白之相應BP相比,AUC增加至少約50%、或至少約60%、或至少約70%、或至少約80%、或至少約90%、或至少約100%、或至少約150%、或至少約200%、或至少約300%。BPXTEN之藥物動力學參數可藉由標準方法測定,該等標準方法包括給藥、在時間間隔獲取血液樣品及使用ELISA、HPLC、放射性分析或此項技術中已知或如本文所描述之其他方法分析蛋白質,接著對資料進行標準計算以導出半衰期及其他PK參數。
本發明進一步提供包含第一及第二BP分子之BPXTEN,其視情況藉由可進一步包含裂解序列之間隔子序列分離或藉由第二XTEN序列分離。在一個實施例中,與不連接至融合蛋白之相應BP相比,當連接至融合蛋白時BP具有較小活性。在此類情況下,BPXTEN可經設計以使得在向個體投與時,BP組分藉由裂解序列之裂解逐漸釋放,因此其恢復活性或結合至其目標受體或配位體之能力。因此,相比於不連接至融合蛋白之BP,前述BPXTEN充當前藥或循環儲存物,產生更長的終末半衰期。
如本文所描述,在例示性實施例中,BPXTEN為XPAC,其中BP為細胞介素。在較佳實施例中,在XPAC之上下文中,細胞介素多肽之活性減弱,且在所需活性位點處(諸如在腫瘤微環境中)之蛋白酶裂解自XPAC釋放出一種細胞介素形式,其作為細胞介素受體促效劑比XPAC更具活性。舉例而言,融合多肽之細胞介素受體活化(促效劑)活性可比作為單獨分子實體之細胞介素多肽的細胞介素受體活化活性小至少約10倍、至少約50倍、至少約100倍、至少約250倍、至少約500倍或至少約1000倍。作為XPAC之一部分的細胞介素多肽在含有與細胞介素多肽基本相同的胺基酸且基本上不包括額外胺基酸且不與其他分子(藉由共價或非共價鍵)相關時,作為單獨的分子實體存在。必要時,作為單獨分子實體之細胞介素多肽可包括一些額外胺基酸序列(諸如標籤或短序列)以輔助表現及/或純化。
在其他實例中,融合多肽之細胞介素受體活化(促效劑)活性比含有由XPAC中之蛋白酶可裂解連接子裂解產生之細胞介素多肽之多肽的細胞介素受體活化活性小至少約10倍、至少約50倍、至少約100倍、至少約250倍、至少約500倍或約1000倍。換言之,含有由XPAC中蛋白酶可裂解連接子之裂解產生之細胞介素多肽之多肽的細胞介素受體活化(促效劑)活性比XPAC之細胞介素受體活化活性大至少約10倍、至少約50倍、至少約100倍、至少約250倍、至少約500倍或至少約1000倍。
BPXTEN之藥理學及醫藥特性
本發明提供包含共價連接至XTEN之BP的BPXTEN組合物,與不連接至XTEN之BP相比,可具有增強之特性,以及增強組合物之各別兩種BP組分的治療及/或生物活性或效應的方法。此外,本發明提供BPXTEN組合物,其相比於含有免疫球蛋白多肽搭配物、具有較短長度之多肽及/或具有重複序列之多肽搭配物的彼等此項技術中已知之融合蛋白具有增強之特性。另外,BPXTEN融合蛋白提供優於化學結合物(諸如聚乙二醇化構築體)之顯著優勢,尤其重組BPXTEN融合蛋白可在細菌細胞表現系統中製備之事實,其可在產品之研究及研發及製造階段兩者處減少時間及成本,且與聚乙二醇化結合物相比,產生更均質更明確的產品,且BPXTEN之產物及代謝物具有較小毒性。
作為治療劑,BPXTEN可能與不包含XTEN之治療劑相比具有許多優勢,包括例如,溶解度增加、熱穩定性增加、免疫原性降低、表觀分子量增加、腎清除率降低、蛋白分解降低、代謝降低、治療效率提高、有效治療劑量降低、生物可用性增加、以將血液水準維持在BP之治療窗內的劑量之間的時間增加、吸收速度「調適」、凍乾穩定性提高、血清/血漿穩定性增強、終末半衰期增加、在血流中之溶解度增加、中和抗體的結合減少、受體介導之清除率降低、副作用減少、保留受體/配位體結合親和力或受體/配位體活化、降解穩定性、凍融穩定性、蛋白酶穩定性、泛素化穩定性、易於投與、與其他醫藥賦形劑或載劑之相容性、在個體中之持久性、儲存穩定性增加(例如儲存期限增加)、在生物體或環境中之毒性減少等。增強之特性的淨效應為當向患有代謝疾病或病症之個體投與時,BPXTEN可引起增強之治療及/或生物效應。
在其中需要增強BP之醫藥或物理化學特性(諸如水溶性或穩定性程度)之其他情況下,第一及第二融合蛋白之第一XTEN序列及第二XTEN序列的長度及/或模體家族組合物可各自經選擇以賦予各別融合蛋白不同程度之溶解度及/或穩定性以使得BPXTEN組合物之總體醫藥特性增強。可使用本文所描述之方法構築及分析BPXTEN融合蛋白以確認物理化學特性且視需要調節XTEN以產生所需特性。在一個實施例中,BPXTEN之XTEN序列經選擇以使得融合蛋白相比於不連接至融合蛋白之BP具有大至少約25%內的水溶性,比不連接至融合蛋白之相應BP大或至少約30%、或至少約40%、或至少約50%、或至少約75%、或至少約100%、或至少約200%、或至少約300%、或至少約400%、或至少約500%或至少約1000%。在此段落中所描述之上文實施例中,融合蛋白之XTEN可與選自
表 2 a- 2 b之XTEN具有至少約80%序列一致性,或約90%、或約91%、或約92%、或約93%、或約94%、或約95%、或約96%、或約97%、或約98%、或約99%至約100%序列一致性。
在一個實施例中,本發明提供BPXTEN組合物,其與不連接至XTEN之可比劑量的相應BP相比,可在治療窗內維持BP組分持續較長時段。在此項技術中應理解,BPXTEN融合蛋白之「可比劑量」將表示更大重量之試劑,但在融合蛋白之劑量中將具有相同的BP莫耳當量及/或相對於BP將具有相同的近似莫耳濃度。
本發明亦提供選擇適合於結合之XTEN以提供所需藥物動力學特性的方法,當與劑量選擇匹配時,該等方法藉由在治療窗內維持BP之循環濃度用以增強的時間段來實現所投與組合物之增加的功效。如本文所用,「治療窗」意謂血液或血漿濃度範圍之藥物或生物製劑的量,其隨時間推移向疾病或病況提供功效或所需藥理學作用且無不可接受之毒性;介於在達成任何積極治療作用的最小量以及導致反應的最大量之間的循環血液濃度的範圍,該反應為個體即將具有毒性之前的反應(以較高劑量或濃度)。另外,治療窗一般涵蓋時間態樣;隨時間推移產生所需藥理學作用之最大及最小濃度,其不產生不可接受之毒性或不良事件。保持在個體之治療窗內的給藥組合物亦可稱為在「安全範圍」內。
劑量最佳化對於所有藥物而言為重要的,尤其對於具有狹窄治療窗之藥物而言。舉例而言,涉及葡萄糖穩態之許多肽具有狹窄治療窗。對於具有狹窄治療窗之BP,諸如升糖素或升糖素類似物,所有呈現多種症狀之患者的標準化單次劑量可能未必總係有效的。由於不同葡萄糖調節肽通常一起用於治療糖尿病個體,故必須亦考慮藉由組合及將其一起給藥來達成之各者及互動作用的效能。此等因素之考慮完全在一般熟練臨床醫師之範圍內,以測定BPXTEN之治療或藥理學有效量,而非導致不可接受之毒性且將其置於安全範圍外的量。
在多數情況下,已建立用於本發明組合物之BP組分之治療窗且其可用於公開文獻中或陳述於含有BP之經批准產品之藥物標籤上。在其他情況下,可建立治療窗。建立給定組合物之治療窗的方法已為熟習此項技術者所知(參見例如,Goodman & Gilman's The Pharmacological Basis of Therapeutics, 第11版, McGraw-Hill (2005))。舉例而言,藉由在患有目標疾病或病症之個體中使用劑量遞增研究確定功效或所需藥理學效應、不良事件之出現及循環血液水準之確定,可確定給定個體或個體群體之治療窗用於給定藥物或生物製劑或生物製劑之組合。劑量遞增研究可經由個體或個體群組中之代謝研究評估BPXTEN之活性,該等個體或個體群組監視如此項技術中已知或如本文所描述之生理或生物化學參數以獲得與代謝疾病或病症相關之一或多個參數,或與特定適應症之有益結果相關之臨床參數,以及觀測及/或所量測以測定無效劑量、不良事件、最大耐受劑量等之參數,以及建立確定或衍生的循環血液水準之藥物動力學參數的量測。結果可隨後與所投與之劑量及治療劑之與前述所測定之參數或作用水準一致的血液濃度相關。藉由此等方法,一系列劑量及血液濃度可與最小有效劑量以及出現所需作用之最大劑量及血液濃度及超過以上則產生毒性相關,由此為所給藥之治療劑建立治療窗。大於最大值之融合蛋白之血液濃度(或如藉由BP組分所量測)將視為在治療窗或安全範圍外。因此,藉由前述方法,將確立C
min血液水準,低於該水準則BPXTEN融合蛋白將不具有所需藥理學作用,且將確立C
max血液水準,其在達到將引發不可接受之副作用、毒性或不良事件之濃度之前將表示最高循環濃度,使其置於BPXTEN之安全範圍外。在確立此類濃度下,給藥之頻率及劑量可藉由量測C
max及C
min來進一步最佳化,以提供適當劑量及給藥頻率以使融合蛋白保持在治療窗內。熟習此項技術者可藉由本文所揭示之手段或藉由此項技術中已知之其他方法證實所投與之BPXTEN在治療窗中保持所需間隔、或需要調節XTEN之劑量或長度或序列。此外,確定治療窗內之保持BPXTEN之適當劑量及給藥頻率會建立治療有效劑量方案;使用治療有效劑量之融合蛋白向有需要之個體投與多個連續劑量的排程會產生保持在治療窗內之連續C
max峰值及/或C
min谷值,且引起與目標疾病、病症或病況相關的至少一種量測參數的改良。在一些情況下,與不連接至XTEN且以可比劑量投與之相應BP相比,以適當劑量向個體投與之BPXTEN可使BPXTEN融合蛋白的血液濃度在治療窗內維持至少約兩倍長的時間;與不連接至XTEN且以可比劑量投與之相應BP相比,維持或者至少約三倍長、或者至少約四倍長、或者至少約五倍長、或者至少約六倍長、或者至少約七倍長、或者至少約八倍長、或者至少約九倍長、或至少約十倍長或更長的時間。如本文所用,「適當劑量」意謂在向個體投與時將在治療窗內產生所需治療或藥理學效應及血液濃度的藥物或生物製劑的劑量。
在一個實施例中,與不連接至融合蛋白且以可比劑量方案向個體投與之相應融合蛋白的生物活性蛋白相比,以治療有效劑量方案投與之BPXTEN在融合蛋白之血液水準的至少兩個連續C
max峰值及/或C
min谷值之間產生至少約三倍長、或者至少約四倍長、或者至少約五倍長、或者至少約六倍長、或者至少約七倍長、或者至少約八倍長、或者至少約九倍長、或至少約十倍長的時間增益。在另一實施例中,與不連接至融合蛋白且使用BP之治療有效劑量方案向個體投與之相應生物活性蛋白組分相比,使用較不頻繁給藥或較低莫耳總劑量之醫藥組合物的融合蛋白以治療有效劑量方案中投與之BPXTEN使一個、或兩個、或三個或更多個量測參數產生可比的改良。所量測之參數可包括本文所揭示之臨床、生化或生理參數中之任一者,或此項技術中已知用於評定患有葡萄糖或胰島素相關病症、代謝疾病或病症、凝血或出血病症或生長激素相關病症之個體的其他參數。
本發明之BPXTEN組合物之活性,包括功能特徵或生物及藥理學活性及結果參數,可藉由此項技術中已知用於量測所需特徵之任何適合的篩選分析測定。包含BP組分之BPXTEN多肽的活性及結構可藉由本文所描述之分析或藉由此項技術中已知之方法量測以確定溶解度、結構及生物活性之保持程度。可進行分析以允許測定BPXTEN對BP受體或配位體的結合特徵,包括結合常數(K
d)、EC
50值以及配位體-受體錯合物解離之半衰期(T
1 / 2)。結合親和力可例如藉由競爭型結合分析量測,該競爭型結合分析偵測特異性結合至受體或配位體之能力的變化。另外,諸如流式細胞量測術或表面電漿子共振之技術可用於偵測結合事件。分析可包含可溶受體分子,或可測定與細胞表現受體之結合。此類分析可包括基於細胞之分析,包括關於增殖、細胞死亡、細胞凋亡及細胞遷移之分析。其他可能的分析可測定所表現之多肽的受體結合,其中該分析可包含可溶性受體分子,或可測定與細胞表現之受體的結合。BPXTEN對於相應BP之目標受體或配位體之結合親和力可使用結合或競爭性結合分析進行分析,諸如藉由晶片結合受體或結合蛋白之Biacore分析或如美國專利5,534,617中所描述之ELISA分析、本文實例中所描述之分析、放射性受體分析或此項技術中已知之其他分析。另外,可使用競爭性ELISA結合分析比較BP序列變異體(以單一組分或以BPXTEN融合蛋白形式分析)與天然BP以測定其與天然BP或其某一部分是否具有相同結合特異性及親和力,使得其適用於包括於BPXTEN中。
本發明提供經分離之BPXTEN,其中BPXTEN對於BP目標受體或配位體之結合親和力可為未結合於XTEN之天然BP對目標受體或配位體的親和力的至少約10%、或至少約20%、或至少約30%、或至少約40%、或至少約50%、或至少約60%、或至少約70%、或至少約80%、或至少約90%、或至少約95%、或至少約99%、或至少約100%或更多。在一些情況下,本發明BPXTEN與該BPXTEN之天然受體或配位體之間的結合親和力K
d為BPXTEN與天然受體或配位體之間的親和力的至少約10
- 4M、或者至少約10
- 5M、或者至少約10
- 6M、或至少約10
- 7M。
在一些實施例中,在本揭示案之組合物(諸如融合蛋白)包含細胞介素之情況下,細胞介素(當連接至融合蛋白中之XTEN時)與相應細胞介素受體之結合活性可藉由半最大有效濃度(EC50)表徵,該半最大有效濃度比表徵細胞介素(當不連接至XTEN時)的相應結合活性的EC50大至少(約)1.1倍、大至少(約)1.2倍、大至少(約)1.3倍、大至少(約)1.4倍、大至少(約)1.5倍、大至少(約)1.6倍、大至少(約)1.7倍、大至少(約)1.8倍、大至少(約)1.9倍或大至少(約)2.0倍。在一些實施例中,細胞介素(當連接至融合蛋白中之XTEN時)與相應細胞介素受體之結合活性可藉由半最大有效濃度(EC50)表徵,該半最大有效濃度比表徵細胞介素(當不連接至XTEN時)的相應結合活性的EC50大(約)1.1倍、大(約)1.2倍、大(約)1.3倍、大(約)1.4倍、大(約)1.5倍、大(約)1.6倍、大(約)1.7倍、大(約)1.8倍、大(約)1.9倍或大(約)2.0倍,或介於上述兩者之間的範圍。在一些實施例中,可在活體外結合分析中測定EC50值。在一些實施例中,細胞介素可為介白素12(IL-12),且相應細胞介素受體可為介白素12受體(IL-12R)。在一些實施例中,活體外結合分析可利用基因工程改造之報導基因細胞株,該細胞株經組態成以報導蛋白的成比例表現對該細胞介素與該相應細胞介素受體之結合作出反應。術語「EC
50」一般係指實現活性物質最大生物反應之一半所需的濃度,且可一般藉由ELISA或基於細胞之分析測定,包括本文所描述之實例的方法。在一些實施例中,活體外結合分析可為報導基因活性分析(諸如
實例 8中所揭示之分析)。舉例而言,例示性報導基因活性分析可基於經基因工程改造之細胞,其藉由穩定地引入所關注受體及所關注信號傳導路徑之相關基因,使得與經工程改造之受體結合觸發引起經工程化基因路徑之活化的信號級聯產生以及後續產生標籤多肽(諸如酶)。
在其他情況下,本發明提供經分離之BPXTEN,其中融合蛋白經設計而以高親和力結合至目標受體,由此產生對天然配位體的拮抗活性。此類BPXTEN之非限制性實例為IL-1raXTEN,其經組態以結合至IL-1受體,使得結合之組合物實質上干擾IL-1α及/或IL-1β與IL-1受體的結合。在某些情況下,拮抗劑BPXTEN(諸如但不限於IL-1raXTEN)對天然配體與目標受體之結合的干擾可為至少約1%、或約10%、或約20%、或約30%、或約40%、或約50%、或約60%、或約70%、或約80%、或約90%、或約95%、或約99%、或約100%。在其他實施例中,本發明提供經分離之BPXTEN融合蛋白(諸如但不限於IL-1raXTEN),其中相比於藉由天然配位體誘發之彼等,經分離之融合蛋白與細胞受體之結合引發小於20%、或小於10%、或小於5%的具有結合之BPXTEN拮抗劑之細胞的信號傳導路徑的活化。在其他情況下,拮抗性BPXTEN組合物以約10 nM或更小、約5 nM或更小、約1 nM或更小、約500 pM或更小、約250 pM或更小、約100 pM或更小、約50 pM或更小或約25 pM或更小之解離常數結合至目標受體。拮抗性BPXTEN之特定構築體之非限制性實例可包括IL-1ra-AM875、IL-1ra-AE864或IL-1ra-AM1296。
在一些情況下,本發明之BPXTEN融合蛋白在已知的或與使用天然BP治療及預防代謝病況及病症有關的活體外生物活性或藥理學效應方面,保留未與融合蛋白連接之相應BP的生物活性的至少約10%、或約20%、30%、40%、50%、60%、70%、80%、90%、95%、98%或99%。在前述實施例之一些情況下,BP組分之活性可由完整的BPXTEN融合蛋白顯現,而在其他情況下,BP組分之活性將主要藉由作用於併入至BPXTEN融合蛋白中之裂解序列的蛋白酶的作用下,自融合蛋白中裂解及釋放時顯現。在前述內容中,如
圖 3 A- 圖 3 E中所說明,BPXTEN可經設計以在當連接至XTEN時降低BP組分對受體或配位體之結合親和力,但當經由併入至BPXTEN序列中之裂解序列的裂解自XTEN釋放時具有增加之親和力,如上文所更充分描述。
在其他情況下,BPXTEN經設計以在連接至XTEN時降低BP組分之結合親和力,以例如藉由降低受體介導之清除率或降低歸因於所投與之組合物的毒性或副作用來增加向個體投與之BPXTEN的終末半衰期。在不連接至XTEN之BP的毒理學無效劑量或血液濃度較低(意謂天然肽具有導致副作用之高可能性)的情況下,本發明提供其中融合蛋白經組態以降低BP組分之生物效能或活性的BPXTEN融合蛋白。
在一些情況下,已發現相比於BPXTEN之活性,BPXTEN可經組態以具有基本上降低之結合親和力(以Kd表示)及相應降低之生物活性,其中組態不引起相應BP組分之結合親和力降低,且此類組態就具有顯示長終末半衰期且保留足夠程度之生物活性的組合物而言為有利的。與XTEN結合至C端之構築體相比,將單一XTEN連接至BP(例如IL-10)之C端可產生針對其目標受體之顯著結合親和力的保留,將XTEN連接至N端降低其結合親和力及相應生物活性。在另一實例中,如實例中所描述,已發現,雖然BP連接至XTEN分子之C端並不實質上干擾與BP受體之結合,但將第二XTEN添加至相同分子之C端(將第二XTEN置放至hGH之C端)降低分子與BP受體之親和力,且亦使得相比於XTEN-BP組態,XTEN-BP-XTEN組態的終末半衰期增加。降低BP與其目標受體之結合親和力的能力可視對於特定BP具有游離N端或C端之要求而定。因此,本發明提供一種藉由產生具有包含至少第一生物活性蛋白及一或多個XTEN之組分的特定N端至C端組態的單鏈融合蛋白構築體來增加BPXTEN之終末半衰期的方法,其中生物活性蛋白及XTEN組分之第一N端至C端組態中的融合蛋白與第二N端至C端組態中之BPXTEN相比具有減少的受體介導之清除率(RMC)及相應的終末半衰期增加。在以上之一個實施例中,BPXTEN經N端至C端組態成BP-XTEN。在以上另一實施例中,BPXTEN經組態成XTEN-BP。在以上另一實施例中,BPXTEN經組態成XTEN-BP-XTEN。在後一實施例中,兩個XTEN分子可相同或其可具有不同序列組成或長度。具有兩個連接至單一BP之XTEN的前述實施例之非限制性實例。具有一個連接至一個XTEN之BP的前述實施例之非限制性實例包括AM875-IL-1ra、AE864-IL-1ra、AM875-IL10或AE864-IL10。本發明涵蓋其他此類構築體,其中來自
表 3或
表 A之BP及來自
表 2 a- 2 b之XTEN取代前述實例之相應組分,且經組態以使得構築體與相應組分之替代組態相比,具有降低之受體介導之清除率。
在一些情況下,該方法提供經組態之BPXTEN,其中經減少之受體介導之清除率可使得終末半衰期與第二組態(其中RMC不減少)中之BPXTEN的半衰期相比增加至少兩倍、或至少三倍、或至少四倍、或至少五倍。本發明利用BP配位體,其中由於降低之締合速率或增加之解離速率而降低對受體之結合親和力可藉由阻礙N端或C端且使用彼末端作為與組合物之另一多肽之鍵聯(無論另一BP、XTEN或間隔子序列)來實現。BPXTEN融合蛋白之特定組態的選擇可降低與受體之結合親和力的程度,使得可達成受體介導之清除率的降低。一般而言,受體活化與RMC耦合以使得多肽與其受體在無活化的情況下之結合不產生RMC,而受體活化產生RMC。然而,在一些情況下,尤其在配位體具有增加之解離速率時,配位體可仍然能夠充分結合以起始細胞信號傳導而不觸發受體介導之清除率,其中最終結果為BPXTEN保持生物可用。在此類情況下,經組態之BPXTEN與產生較高程度之RMC的彼等組態相比具有增加之半衰期。
在需要降低結合親和力以便降低受體介導之清除率但需要保持至少一部分生物活性之情況下,應清楚,仍然必須維持足以獲得所需受體活化之結合親和力。因此,在一個實施例中,本發明提供經組態BPXTEN,以使得與其中結合親和力不降低之組態中之相應BPXTEN相比,經組態BPXTEN對於目標受體之結合親和力為結合親和力的約0.01%至40%,或約0.1%至30%,或約1%至20%範圍內。與其中BP組分與目標受體之結合親和力不降低之組態中之相應BPXTEN的結合親和力相比,或與不連接至融合蛋白之BP相比,在可比條件下測定,經組態之BXTEN的結合親和力因此較佳降低至少約80%、或至少約85%、或至少約90%、或至少約95%、或至少約99%、或至少約99.9%、或至少約99.99%。以不同方式表現,經組態之BPXTEN之BP組分可具有結合親和力,該結合親和力小至其中BP組分之結合親和力不降低之組態中之BPXTEN的相應BP組分的結合親和力的約0.01%、或至少約0.1%、或至少約1%、或至少約2%、或至少約3%、或至少約4%、或至少約5%、或至少約10%、或至少約20%。在此段落中所描述之上文前述實施例中,與對應天然BP或具有其中相應BP組分之結合親和力不降低之組態的BPXTEN相比,經組態之BPXTEN對目標受體之結合親和力將「基本上降低」。因此,本發明提供組合物及藉由組態BPXTEN以產生RMC降低之組合物的方法,以便能夠結合及活化足夠數目之受體以獲得所需活體內生物反應,同時避免活化更多獲得此類反應所需數目的受體。在一個實施例中,BPXTEN經組態以使得本發明BP在BPXTEN之N端處,其中與經組態有連接至XTEN之C端之本發明BP且天然BP之生物活性之至少一部分保留的BPXTEN相比,所投與之BPXTEN的RMC降低。在另一實施例中,BPXTEN經組態以使得本發明BP在BPXTEN之C端處,其中與經組態有本發明BP位於BPXTEN之N端處且天然BP之生物活性之至少一部分保留的BPXTEN相比,所投與之BPXTEN的RMC降低。在另一實施例中,BPXTEN經N端至C端組態為XTEN-BP-XTEN,其中與經組態有一個XTEN且天然BP之生物活性之至少一部分保留的BPXTEN相比,所投與之BPXTEN的RMC降低。熟習此項技術者將顯而易見,本發明涵蓋實現此特性之其他組態;例如添加BP之第二分子或間隔子序列。在此段落中所描述之上文前述實施例中,與其中BP組分之結合親和力及RMC不降低之經組態的BPXTEN相比,BPXTEN的半衰期可為增加至少約50%、或至少約75、或至少約100%、或至少約150%、或至少約200%、或至少約300%。在此段落中所描述之上文前述實施例中,與不連接至XTEN之BP相比或與其中BP組分對受體保持與天然BP相當之結合親和力的BPXTEN組態相比,增加之半衰期可准許較高劑量及降低之給藥頻率。
特定活體內及離體生物分析亦可用於評估待併入至BPXTEN中之各經組態之BPXTEN及/或BP組分的生物活性。舉例而言,胰臟β細胞之胰島素分泌及/或轉錄的增加可藉由此項技術中已知之方法量測。組織之葡萄糖攝取亦可藉由諸如葡萄糖夾鉗檢定及其類似者之方法評估。適合於評估所投與之BPXTEN融合蛋白在治療代謝疾病及病症中之活性的其他活體內及離體參數包括空腹葡萄糖含量、餐後葡萄糖含量、葡萄糖穩態、對口服葡萄糖耐受性測試之反應、胰島素攻擊之反應、HA
1 c、熱量攝入、飽腹感、胃排空速率、胰臟分泌、胰島素分泌、外周組織胰島素敏感度、β細胞質量、β細胞破壞、血脂含量或曲線、身體質量指數或體重。基於此等分析或此項技術中已知之其他分析之結果,可確認或調節(若需要)及再分析BPXTEN組態或組合物以確認目標結合親和力或生物活性。
用於量測所表現蛋白質之物理及結構特性的特定分析及方法為此項技術中已知的,包括用於測定特性,諸如蛋白質聚集、溶解度、二級及三級結構、熔融特性、污染及水含量等之方法。此類方法包括分析型離心、EPR、HPLC-離子交換、HPLC-尺寸排阻層析法、逆相HPLC、光散射、毛細電泳法、圓二色性、差示掃描熱量測定、螢光、HPLC-離子交換、HPLC-尺寸排阻、IR、NMR、拉曼光譜法(Raman spectroscopy)、折射法及UV/可見光譜法。其他方法揭示於Arnau等人, Prot Expr and Purif (2006) 48, 1-13中。在本發明中應用此等方法將在熟習此項技術者之掌握範圍內。
本發明之組合物之用途
在另一態樣中,本發明提供一種用於在由BP介導之疾病、病症或病況中達成有益效應之方法。本發明解決BP之缺點及/或侷限性,其在最小有效劑量與最大耐受劑量之間具有相對短的終末半衰期及/或狹窄治療窗。
在一個實施例中,本發明提供一種在個體中達成有益效應之方法,其包含向個體投與治療或預防有效量之BPXTEN的步驟。有效量可在幫助治療疾病或病症方面產生有益效應。在一些情況下,實現有益效應之方法可包括投與治療有效量之BPXTEN融合蛋白組合物以治療患病之個體。
在一個實施例中,該方法包含向有需要之個體投與治療有效量之醫藥組合物,該醫藥組合物包含BPXTEN融合蛋白組合物,該組合物包含連接至XTEN序列之BP及至少一種醫藥學上可接受之載劑,與由投與包含與不連接至XTEN且以可比劑量投與之BP的醫藥組合物介導的效應相比,使得由BP組分介導之至少一個參數,生理條件或臨床結果的改善更大。在一個實施例中,醫藥組合物以治療有效劑量投與。在另一實施例中,醫藥組合物使用多個連續劑量在給藥期時長內使用治療有效劑量方案(如本文所定義)投與。
由於如本文所描述之BPXTEN之增強PK參數,與不連接至XTEN之相應BP相比,可使用更長的劑量之間的間隔來投與BP以預防、治療、緩解、逆轉或改善代謝疾病、病症或病況之症狀或臨床異常或延長所治療個體之存活期。
本發明之方法可包括投與連續劑量之治療有效量之BPXTEN持續足以達成及/或維持所需參數或臨床效應之時間段,且治療有效量之此類連續劑量建立針對BPXTEN之治療有效劑量方案;例如融合蛋白組合物之連續投與劑量的排程,其中該等劑量係以治療有效量給與以對任何臨床徵象或症狀、態樣、所量測之代謝疾病狀態或病況之參數或特徵(包括但不限於本文所描述之彼等)產生持久有益效應。
BPXTEN之治療有效量可根據諸如個體之疾病狀態、年齡、性別及體重以及抗體或抗體部分在個體中引發所需反應之能力等因素而變化。治療有效量亦為BPXTEN之治療有益效應超過其任何毒性或有害效應的量。預防有效量係指達成所需預防結果必需之時間段所需的BPXTEN之量。
對於本發明方法,較長效的BPXTEN組合物較佳,以改良患者便利性,以增加劑量之間的時間間隔及減少達成持續效應所需之藥物的量。在一個實施例中,治療方法包含向有需要之個體投與治療有效劑量之BPXTEN,與不連接至融合蛋白且以可比劑量向個體投與之相應BP組分相比,其產生在針對組合物之融合蛋白建立之治療窗內花費的時間增益。在一些情況下,治療窗內花費之時間增益與不連接至融合蛋白且以可比劑量向個體投與之相應BP組分相比為至少約三倍、或至少約四倍、或至少約五倍、或至少約六倍、或至少約八倍、或至少約10倍、或至少約20倍、或至少約40倍。該等方法進一步提供使用治療有效劑量方案向有需要之個體投與多個連續劑量之BPXTEN,與不連接至融合蛋白且使用針對BP建立之劑量方案投與的相應BP組分相比,可在融合蛋白之血液水準的連續C
max峰值及/或C
min谷值之間產生時間增益。在前述實施例中,與不連接至融合蛋白且使用針對BP建立之劑量方案投與的相應BP組分相比,連續C
max峰值及/或C
min谷值之間的花費之時間增益可為至少約三倍、或至少約四倍、或至少約五倍、或至少約六倍、或至少約八倍、或至少約10倍、或至少約20倍或至少約40倍。在此段落中所描述之上文所描述之實施例中,與不連接至融合蛋白且以可比單位劑量或劑量方案向個體投與之相應BP組分相比,使用較低莫耳單位劑量之融合蛋白投與融合蛋白可使得參數(本文中揭示為適用於評估本發明疾病、病況或病症)中之至少一者得到改善。
在一個實施例中,BPXTEN可具有使得臨床、生物化學或生理參數中之一者得到改善之活性,該活性大於不連接至XTEN之BP組分的活性,使用相同分析或基於所量測臨床參數來測定。在另一實施例中,BPXTEN可在兩個或更多個臨床或代謝相關參數(例如糖尿病個體中之葡萄糖穩態及體重控制,或血友病個體中之凝血酶原及出血時間減少,或生長激素缺乏個體中之肌肉質量及骨密度增加)中具有活性,各自由不同BP中之一者介導,該等BP共同地產生與不連接至XTEN之BP組分相比增強的效應,使用相同分析或基於所量測臨床參數來測定。在另一實施例中,投與BPXTEN可使得臨床或生化或生理參數中之一或多者中之活性的持續時間比不連接至XTEN之單一BP組分中之一者的活性的持續時間要長,使用相同分析或基於所量測臨床參數來測定。
在一些實施例中,本揭示案提供一種治療或預防個體之疾病或病況的方法,該方法包含向個體投與治療有效量之融合蛋白或包含該融合蛋白之組合物,以上所有均揭示於本文中。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況或發炎性或自體免疫性疾病。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況。在一些實施例中,疾病或病況可為癌症或癌症相關疾病或病況。必要時,本發明融合物及組合物可與治療有效量之至少一種免疫檢查點抑制劑結合使用。
本發明進一步涵蓋根據本文所提供之方法使用之BPXTEN可與適用於治療以下的其他治療方法及醫藥組合物一起投與:癌症、類風濕性關節炎、多發性硬化、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症、精神分裂症
、病毒感染(例如,慢性C型肝炎、AIDS)、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症、發炎性病況及自體免疫性病況。
在一些情況下,投與BPXTEN可准許使用較低劑量之共投與的醫藥組合物來實現個體中之疾病、病症或病況的相當臨床效應或量測參數。
儘管有前述規定,但在某些實施例中,根據本發明之方法使用之BPXTEN可預防或延遲在患有葡萄糖相關疾病、代謝疾病或病症、凝血病症或生長激素缺乏或生長病症之個體中對額外治療方法或使用藥物或其他醫藥組合物的需要。在其他實施例中,BPXTEN可減少治療潛在疾病、病症或病況所需之額外治療方法或藥物或其他醫藥組合物的量、頻率或持續時間。
在另一態樣中,本發明提供一種設計具有所需藥理學或醫藥特性之BPXTEN組合物的方法。設計及製備BPXTEN融合蛋白考慮到各種目標(相比於不連接至融合蛋白之BP組分),包括改良用於治療代謝疾病或病症之治療功效,增強與BP相比融合蛋白之藥物動力學特徵,降低達成藥理學效應所需之劑量或給藥頻率,增強醫藥特性,且增強BP組分保持在治療窗內延長時段的能力。
一般而言,設計及生產融合蛋白及本發明組合物中之步驟可如圖4至6中所示,包括:(1)選擇BP(例如天然蛋白質、肽激素、具有活性之肽類似物或衍生物、肽片段等)以治療特定疾病、病症或病況;(2)選擇將賦予所得BPXTEN所需PK及物理化學特徵之XTEN(例如向個體投與組合物使得融合蛋白與不連接至XTEN之BP相比具有維持在治療窗內持續較大時段);(3)建立BPXTEN之所需N端至C端組態以達成所需功效或PK參數;(4)建立編碼經組態之BPXTEN的表現載體的設計;(5)用表現載體轉化適合之宿主;及(6)表現及回收所得融合蛋白。對於需要增加半衰期(大於16小時)或增加在治療窗內花費之時間段的彼等BPXTEN,經選擇用於併入的XTEN將一般具有至少約500個、或約576個、或約864個、或約875個、或約913個、或約924個胺基酸殘基,其中單一XTEN將併入至BPXTEN中。在另一實施例中,BPXTEN可包含前述長度之第一XTEN,及約144個、或約288個、或約576個、或約864個、或約875個、或約913個、或約924個胺基酸殘基的第二XTEN。
在其他情況下,在不需要增加半衰期但需要增加醫藥特性(例如溶解度)之情況下,BPXTEN可經設計以包括較短長度之XTEN。在前述之一些實施例中,BPXTEN可包含連接至XTEN之BP,該XTEN具有至少約24個、或約36個、或約48個、或約60個、或約72個、或約84個、或約96個胺基酸殘基,其中在生理條件下融合蛋白之溶解度比與連接至XTEN的相應BP的溶解度大至少三倍,或者比連接至XTEN之升糖素大至少四倍、或五倍、或六倍、或七倍、或八倍、或九倍、或至少10倍、或至少20倍、或至少30倍、或至少50倍、或至少60倍。在另其他情況下,其中需要含葡萄糖之BPXTEN融合蛋白的半衰期為2至6小時(例如在治療夜間低血糖中),融合蛋白可設計成具有中等長度之XTEN,該等中等長度諸如含升糖素之BPXTEN組分中約100個胺基酸、或約144個胺基酸、或約156個胺基酸、或約168個胺基酸、或約180個胺基酸、或約196個胺基酸。
在另一態樣中,本發明提供製備BPXTEN組合物以與天然BP相比改良製造簡易性、產生增加之穩定性、增加之水溶解度及/或調配簡易性的方法。在一個實施例中,本發明包括增加BP之水溶解度之方法,其包含以下步驟:將BP連接至一或多個XTEN,使得與未融合狀態下之BP相比,可在生理條件下達成呈可溶形式之所得BPXTEN的較高濃度。當併入至融合蛋白中時,促成XTEN之特性以賦予BP增加之水溶解度的因素包括XTEN融合搭配物之高溶解度及XTEN在溶液中之分子之間的低程度之自身聚集。在一些實施例中,本方法產生BPXTEN融合蛋白,其中與未稠合之BP相比,水溶解度為至少約50%、或至少約60%大、或至少約70%大、或至少約80%大、或至少約90%大、或至少約100%大、或至少約150%大、或至少約200%大、或至少約400%大、或至少約600%大、或至少約800%大、或至少約1000%大、或至少約2000%大、或至少約4000%大、或至少約6000%大。
在另一實施例中,本發明包括一種增加BP之儲存期限之方法,其包含以下步驟:將BP與經選擇之一或多個XTEN連接以使得所得BPXTEN之儲存期限與呈未融合狀態之BP相比延長。如本文所用,儲存期限係指在溶液中或在一些其他儲存調配物中之BP或BPXTEN之功能活性保持穩定而無不當活性損失的時間段。如本文所使用,「功能活性」係指藥理學效應或生物活性,諸如結合受體或配位體之、或酶活性、或顯示與BP相關之一或多種已知功能活性的能力,如此項技術中已知。降解或聚集之BP與保留在溶液中之BP相比通常具有降低之功能活性或降低之生物可用性。當併入至融合蛋白中時,促成延長BP之儲存期限之方法的能力的因素包括增加之水溶解度、減少之溶液中的自身聚集及增加之XTEN融合搭配物的熱穩定性。特定言之,XTEN聚集物之低趨向促進調配含有較高藥物濃度之BP的醫藥製劑的方法,且XTEN之熱穩定性促成BPXTEN融合蛋白之特性以長時間保持可溶及功能活性。在一個實施例中,該方法產生具有「長期」或「延長」儲存期限之BPXTEN融合蛋白,其相對於已經受相同儲存及處理條件之標準物展現出更大的活性。標準物可為未稠合之全長BP。在一個實施例中,該方法包括用一或多種醫藥學上可接受之賦形劑調配經分離之BPXTEN的步驟,該一或多種醫藥學上可接受之賦形劑增強XTEN保留其非結構化構形之能力,且使得BPXTEN在調配物中保持可溶的時間大於相應未融合之BP的時間。在一個實施例中,該方法涵蓋連接BP與XTEN以產生BPXTEN融合蛋白,使得溶液在給定時間點且當經歷與標準物相同之儲存及處理條件時,保持大於約100%之標準物之功能活性,或大於約105%、110%、120%、130%、150%或200%之標準物之功能活性,由此增強其儲存期限。
亦可就儲存之後剩餘之功能活性而言評估儲存期限,標準化為儲存開始時之功能活性。具有如藉由長期或延長之功能活性展現之長期或延長之儲存期限的本發明之BPXTEN融合蛋白當經歷相同條件持續相同時間段時,可保留不連接至XTEN之等效BP的約50%的功能活性、或約60%、70%、80%或90%更多的功能活性。舉例而言,包含融合至XTEN序列之腸促胰島素類似物-4(exendin-4)或升糖素的本發明之BPXTEN融合蛋白可在各種溫度條件下在溶液中保持其初始活性的約80%或更多,持續多達5週或更多之時段。在一些實施例中,當在80℃下加熱10分鐘時,BPXTEN在溶液中保留其初始活性的至少約50%、或約60%、或至少約70%、或至少約80%、且最佳至少約90%或更多。在其他實施例中,當在37℃下加熱或維持約7天時,BPXTEN在溶液中保留其初始活性的至少約50%、較佳至少約60%、或至少約70%、或至少約80%、或者至少約90%或更多。在另一實施例中,BPXTEN融合蛋白在約30℃至約70℃之溫度下暴露約一小時至約18小時之時段之後,保留其功能活性的至少約80%或更多。在此段落中所描述之上文前述實施例中,BPXTEN之保留活性在給定時間點與不連接至融合蛋白之相應BP之保留活性相比大至少約兩倍、或至少約三倍、或至少約四倍、或至少約五倍、或至少約六倍。
本發明之DNA序列
本發明提供編碼BPXTEN嵌合多肽之經分離聚核酸及與編碼BPXTEN嵌合多肽之聚核酸分子互補的序列,包括同源變異體。在另一態樣中,本發明涵蓋方法,該方法產生編碼BPXTEN嵌合多肽之聚核酸及與編碼BPXTEN嵌合多肽之聚核酸分子互補的序列,包括同源變異體。一般而言,且如圖4至6中所示,產生編碼BPXTEN融合蛋白之聚核苷酸序列且表現所得基因產物的方法包括組裝編碼BP及XTEN之核苷酸;將該等組分連接於框架中;將該編碼基因併入至適當表現載體中;用表現載體轉化適當宿主細胞;及使融合蛋白表現於經轉化之宿主細胞中,由此產生生物活性BPXTEN多肽。分子生物學中之標準重組技術可用於製造本發明之聚核苷酸及表現載體。
根據本發明,編碼BPXTEN之核酸序列可用於產生導引適當宿主細胞中之BPXTEN融合蛋白之表現的重組DNA分子。設想若干選殖策略適用於執行本發明,其中多者可用於產生構築體,該構築體包含編碼本發明之BPXTEN組合物之融合蛋白的基因或其互補序列。在一個實施例中,選殖策略將用於產生編碼單體BPXTEN之基因,該單體BPXTEN包含至少第一BP及至少第一XTEN多肽或其互補序列。在另一實施例中,選殖策略將用於產生編碼單體BPXTEN之基因,該單體BPXTEN包含一個BP之第一及第二分子及至少一個第一XTEN(或其互補序列),該第一XTEN將用於轉化宿主細胞以表現用於調配BPXTEN組合物之融合蛋白。在此段落中所描述之上文前述實施例中,基因可進一步包含編碼間隔子序列之核苷酸,該等間隔子序列亦可編碼裂解序列。
在設計所需XTEN序列時,發現儘管在創建XTEN編碼序列中使用「建構組元」分子方法,但仍可實現本發明組合物之XTEN的非重複性質。此藉由使用聚核苷酸編碼序列模體之庫來達成,該等聚核苷酸隨後多聚化以產生編碼XTEN序列之基因(參見圖4及5)。因此,雖然表現XTEN可由少至四種不同之序列模體之多個單元組成,因為模體本身由非重複胺基酸序列組成,但整個XTEN序列呈現非重複。因此,在一個實施例中,XTEN編碼聚核苷酸包含編碼非重複序列或模體的多個聚核苷酸,其可操作地連接於框架中且所得表現XTEN胺基酸序列非重複。
在一種方法中,首先製備含有對應於BPXTEN融合蛋白之DNA序列的構築體。編碼組合物BP之DNA可獲自使用標準方法自咸信具有BP mRNA且以可偵測水準表現之組織或分離細胞製備的cDNA庫。必要時,編碼序列可使用如Sambrook,等人, 前述中所描述之習知引物延伸程序獲得,以偵測尚未反轉錄成cDNA之mRNA的前驅體及加工中間物。因此,DNA可方便地自製備自此類來源之cDNA庫獲得。BP編碼基因亦可獲自基因體或藉由此項技術中已知之標準合成程序(例如,自動化核酸合成)使用獲自公開可獲得之資料庫、專利或文獻參考文獻的DNA序列產生。此類程序為此項技術中熟知且詳盡描述於科學及專利文獻中。舉例而言,序列可獲自化學文摘服務(CAS)登記號(由美國化學協會公開)及/或Genbank寄存編號(例如,基因座ID、NP_XXXXX及XP_XXXXX)模型蛋白質標識符,其可經由國家生物技術資訊中心(NCBI)網站獲得,於全球資訊網ncbi.nlm.nih.gov獲得,其對應於CAS登記或GenBank資料庫中含有BAP或BAP片段或變異體的胺基酸序列的條目。對於本文提供之此類序列標識符,與此等CAS及Genbank及GenSeq寄存編號中之每一者相關的概述頁面以及所引用之雜誌出版物(例如,PubMed ID編號(PMID))各自以全文引用之方式併入,尤其相對於其中所描述之胺基酸序列。在一個實施例中,BP編碼基因編碼來自
表 3或
表 A中之任一者之蛋白質或其片段或變異體。
編碼本發明BPXTEN蛋白質之BP部分的基因或聚核苷酸,在表現之融合蛋白的情況下,將包含單一BP,可接著選殖至構築體中,該構築體可為質體或其他載體,在適當的轉錄及轉譯序列的控制下,用於生物系統中的高水準蛋白質表現。在後續步驟中,編碼XTEN之第二基因或聚核苷酸藉由將其選殖至與編碼BP之基因相鄰且同框之構築體中而基因融合至編碼BP基因之N端及/或C端的核苷酸。此第二步驟可經由接合或多聚化步驟進行。在此段落中所描述之上文前述實施例中,應理解,所產生之基因構築體可替代地為編碼相應融合蛋白之相應基因的補體。
編碼XTEN之基因可在一或多個步驟中完全以合成方式或藉由與酶促過程(諸如限制酶介導之選殖、PCR及重疊延伸)組合的合成來製得。XTEN多肽可經構築使得XTEN編碼基因具有低重複性,同時所編碼之胺基酸序列具有一定程度的重複性。編碼具有非重複序列之XTEN的基因可使用基因合成之標準技術自寡核苷酸組裝。基因設計可使用使密碼子使用及胺基酸組成最佳化之演算法進行。在本發明之一個方法中,產生相對短的XTEN編碼聚核苷酸構築體之庫且接著進行組裝,如圖4及5。此可為純密碼子庫,使得各庫成員具有相同胺基酸序列,但許多不同編碼序列為可能的。此類庫可自部分隨機化寡核苷酸組裝且用於產生包含序列模體之XTEN區段的大型庫。隨機化方案可經最佳化以針對各位置以及密碼子使用來控制胺基酸選擇。
聚核苷酸庫
在另一態樣中,本發明提供編碼XTEN序列之聚核苷酸庫,該等XTEN序列可用於組裝編碼所需長度及序列之XTEN的基因。
在某些實施例中,XTEN編碼庫構築體包含編碼固定長度之多肽區段的聚核苷酸。作為初始步驟,可組裝編碼9至14個胺基酸殘基之模體的寡核苷酸庫。在一較佳實施例中,組裝編碼12個胺基酸基之模體的寡核苷酸庫。
XTEN編碼序列區段可二聚或多聚化為較長編碼序列。二聚或多聚化可藉由接合、重疊延伸、PCR組裝或此項技術中已知之類似選殖技術進行。此過程可重複多次,直至所得XTEN編碼序列已達到序列組構及所需長度,提供XTEN編碼基因。如將瞭解,編碼12個胺基酸之聚核苷酸庫可二聚為編碼36個胺基酸之聚核苷酸庫。轉而,編碼36個胺基酸之聚核苷酸庫可連續二聚為含有編碼XTEN序列之連續較長長度之聚核苷酸的庫。在一些實施例中,可以組裝編碼僅限於特定序列XTEN家族的胺基酸的聚核苷酸庫;例如
表 1之AD、AE、AF、AG、AM或AQ序列。在其他實施例中,庫可包含編碼來自
表 1之模體家族序列中之兩者或更多者的序列。庫又可用於連續二聚化或接合以獲得編碼XTEN序列,例如72、144、288、576、864、912、923、1296個胺基酸或多達約3000個胺基酸之總長度以及中等長度之聚核苷酸序列庫。在一些情況下,聚核苷酸庫序列亦可包括用作「定序島」之額外鹼基,如下文更充分描述。
圖 5為本發明之實施例中XTEN聚核苷酸構築體及BPXTEN聚核苷酸構築體之組裝中之代表性非限制性步驟的示意性流程圖。將個別寡核苷酸
501可黏接成序列模體
502,諸如12個胺基酸模體(「12聚體」),其隨後與含有BbsI及KpnI限制性位點之寡核苷酸
503 接合。使來自庫之額外序列模體黏接成12聚體,直至達成XTEN基因
504之所需長度。將XTEN基因選殖至填充(stuffer)載體中。載體可視情況編碼旗標序列
506,隨後為由BsaI、BbsI及KpnI位點側接之填充序列
507及在該種狀況下單一BP基因(在此實例中編碼腸促胰島素類似物-4)
508,產生編碼包含單一BP之BPXTEN的基因
500。用於編碼XTEN及前驅體序列之聚核苷酸的XTEN名稱及SEQ ID NO之非詳盡清單提供於
表 8中。
表8:XTEN及前驅體序列之DNA序列
XTEN 名稱 | SEQ ID NO: | DNA 序列 |
AE144 | 247 | GGTAGCGAACCGGCAACTTCCGGCTCTGAAACCCCAGGTACTTCTGAAAGCGCTACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCTGGCTCTGAAACCCCAGGTAGCCCGGCAGGCTCTCCGACTTCCACCGAGGAAGGTACCTCTACTGAACCTTCTGAGGGTAGCGCTCCAGGTAGCGAACCGGCAACCTCTGGCTCTGAAACCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAAACTCCAGGTAGCGAACCGGCTACTTCCGGTTCTGAAACTCCAGGTACCTCTACCGAACCTTCCGAAGGCAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTAGCGAACCGGCTACTTCTGGCTCTGAGACTCCAGGTACTTCTACCGAACCGTCCGAAGGTAGCGCACCA |
AF144 | 248 | GGTACTTCTACTCCGGAAAGCGGTTCCGCATCTCCAGGTACTTCTCCTAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACTGCTCCAGGTTCTACCAGCTCTACCGCTGAATCTCCTGGCCCAGGTTCTACCAGCGAATCCCCGTCTGGCACCGCACCAGGTTCTACTAGCTCTACCGCAGAATCTCCGGGTCCAGGTACTTCCCCTAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTACTCCGGAAAGCGGCTCCGCATCTCCAGGTTCTACTAGCTCTACTGCTGAATCTCCTGGTCCAGGTACCTCCCCTAGCGGCGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTACCTCCCCTAGCGGTGAATCTTCTACCGCACCA |
AE288 | 249 | GGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCA |
AE576 | 250 | GGTAGCCCGGCTGGCTCTCCTACCTCTACTGAGGAAGGTACTTCTGAAAGCGCTACTCCTGAGTCTGGTCCAGGTACCTCTACTGAACCGTCCGAAGGTAGCGCTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTAGCGAACCGGCTACTTCTGGCTCTGAGACTCCAGGTACTTCTACCGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACTGAACCGTCTGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCGGAATCCGGCCCAGGTACCTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAAGGCAGCGCTCCAGGTACCTCTACTGAACCTTCCGAGGGCAGCGCTCCAGGTACCTCTACCGAACCTTCTGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCA |
AF576 | 251 | GGTTCTACTAGCTCTACCGCTGAATCTCCTGGCCCAGGTTCCACTAGCTCTACCGCAGAATCTCCGGGCCCAGGTTCTACTAGCGAATCCCCTTCTGGTACCGCTCCAGGTTCTACTAGCTCTACCGCTGAATCTCCGGGTCCAGGTTCTACCAGCTCTACTGCAGAATCTCCTGGCCCAGGTACTTCTACTCCGGAAAGCGGTTCCGCTTCTCCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCGTCTGGCACTGCACCAGGTACCTCTACCCCTGAAAGCGGTTCCGCTTCTCCAGGTTCTACTAGCGAATCTCCTTCTGGTACCGCTCCAGGTACTTCTACCCCTGAAAGCGGCTCCGCTTCTCCAGGTTCCACTAGCTCTACCGCTGAATCTCCGGGTCCAGGTTCTACTAGCTCTACTGCAGAATCTCCTGGCCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTACTTCTACCCCTGAAAGCGGTTCTGCATCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTACCCCGGAAAGCGGCTCTGCTTCTCCAGGTACTTCTACCCCGGAAAGCGGCTCCGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGTACCGCTCCAGGTTCTACCAGCGAATCCCCGTCTGGTACTGCTCCAGGTTCTACCAGCGAATCTCCTTCTGGTACTGCACCAGGTTCTACTAGCTCTACTGCAGAATCTCCTGGCCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTACTTCTACCCCTGAAAGCGGTTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCGTCTGGCACTGCACCAGGTACCTCTACCCCTGAAAGCGGTTCCGCTTCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCGTCTGGCACTGCACCAGGTACCTCTACCCCTGAAAGCGGTTCCGCTTCTCCAGGTACTTCTCCGAGCGGTGAATCTTCTACCGCACCAGGTTCTACTAGCTCTACCGCTGAATCTCCGGGCCCAGGTACTTCTCCGAGCGGTGAATCTTCTACTGCTCCAGGTTCCACTAGCTCTACTGCTGAATCTCCTGGCCCAGGTACTTCTACTCCGGAAAGCGGTTCCGCTTCTCCAGGTTCTACTAGCGAATCTCCGTCTGGCACCGCACCAGGTTCTACTAGCTCTACTGCAGAATCTCCTGGCCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTACTTCTACCCCTGAAAGCGGTTCTGCATCTCCA |
AM875 | 252 | GGTACTTCTACTGAACCGTCTGAAGGCAGCGCACCAGGTAGCGAACCGGCTACTTCCGGTTCTGAAACCCCAGGTAGCCCAGCAGGTTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACTAGCGAATCCCCGTCTGGTACTGCTCCAGGTACTTCTACTCCTGAAAGCGGTTCCGCTTCTCCAGGTACCTCTACTCCGGAAAGCGGTTCTGCATCTCCAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCCGGCCCAGGTAGCCCGGCAGGTTCTCCGACTTCCACTGAGGAAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACCTCTACTGAACCTTCCGAAGGCAGCGCTCCAGGTACCTCTACCGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTACTTCTACTGAACCTTCCGAAGGTAGCGCTCCAGGTAGCGAACCTGCTACTTCTGGTTCTGAAACCCCAGGTAGCCCGGCTGGCTCTCCGACCTCCACCGAGGAAGGTAGCTCTACCCCGTCTGGTGCTACTGGTTCTCCAGGTACTCCGGGCAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCTACTGGCTCTCCAGGTACCTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACTCCAGGTAGCCCTGCTGGCTCTCCGACTTCTACTGAGGAAGGTAGCCCGGCTGGTTCTCCGACTTCTACTGAGGAAGGTACTTCTACCGAACCTTCCGAAGGTAGCGCTCCAGGTGCAAGCGCAAGCGGCGCGCCAAGCACGGGAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCTGAATCTCCTGGCCCAGGTTCTACTAGCGAATCTCCGTCTGGCACCGCACCAGGTACTTCCCCTAGCGGTGAATCTTCTACTGCACCAGGTACCCCTGGCAGCGGTACCGCTTCTTCCTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGCTCTCCAGGTTCTAGCCCGTCTGCATCTACCGGTACCGGCCCAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACTCCAGGTACTTCTGAAAGCGCTACTCCGGAATCCGGCCCAGGTAGCGAACCGGCTACTTCCGGCTCTGAAACCCCAGGTTCCACCAGCTCTACTGCAGAATCTCCGGGCCCAGGTTCTACTAGCTCTACTGCAGAATCTCCGGGTCCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTAGCGAACCGGCAACCTCTGGCTCTGAAACTCCAGGTAGCGAACCTGCAACCTCCGGCTCTGAAACCCCAGGTACTTCTACTGAACCTTCTGAGGGCAGCGCACCAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTACTTCTACCGAACCGTCCGAAGGCAGCGCTCCAGGTACCTCTACTGAACCTTCCGAGGGCAGCGCTCCAGGTACCTCTACCGAACCTTCTGAAGGTAGCGCACCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTTCTAGCCCGTCTGCTTCCACTGGTACTGGCCCAGGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTAGCGAACCTGCTACCTCCGGTTCTGAAACCCCAGGTACCTCTGAAAGCGCAACTCCGGAGTCTGGTCCAGGTAGCCCTGCAGGTTCTCCTACCTCCACTGAGGAAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTTCTAGCCCGTCTGCTTCCACTGGTACTGGCCCAGGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCA |
AE864 | 253 | GGTAGCCCGGCTGGCTCTCCTACCTCTACTGAGGAAGGTACTTCTGAAAGCGCTACTCCTGAGTCTGGTCCAGGTACCTCTACTGAACCGTCCGAAGGTAGCGCTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTAGCGAACCGGCTACTTCTGGCTCTGAGACTCCAGGTACTTCTACCGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACTGAACCGTCTGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCGGAATCCGGCCCAGGTACCTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAAGGCAGCGCTCCAGGTACCTCTACTGAACCTTCCGAGGGCAGCGCTCCAGGTACCTCTACCGAACCTTCTGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCA |
AF864 | 254 | GGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACTAGCGAATCCCCGTCTGGTACTGCTCCAGGTACTTCTACTCCTGAAAGCGGTTCCGCTTCTCCAGGTACCTCTACTCCGGAAAGCGGTTCTGCATCTCCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCACCAGGTTCTACTAGCGAATCTCCGTCTGGCACTGCTCCAGGTACTTCTCCTAGCGGTGAATCTTCTACCGCTCCAGGTACTTCCCCTAGCGGCGAATCTTCTACCGCTCCAGGTTCTACTAGCTCTACTGCAGAATCTCCGGGCCCAGGTACCTCTCCTAGCGGTGAATCTTCTACCGCTCCAGGTACTTCTCCGAGCGGTGAATCTTCTACCGCTCCAGGTTCTACTAGCTCTACTGCAGAATCTCCTGGCCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTACTTCTACCCCTGAAAGCGGTTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCGTCTGGCACTGCACCAGGTACCTCTACCCCTGAAAGCGGTTCCGCTTCTCCAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTACTTCTCCGAGCGGTGAATCTTCTACCGCACCAGGTTCTACTAGCTCTACCGCTGAATCTCCGGGCCCAGGTACTTCTCCGAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTACTCCTGAAAGCGGTTCTGCATCTCCAGGTTCCACTAGCTCTACCGCAGAATCTCCGGGCCCAGGTTCTACTAGCTCTACTGCTGAATCTCCTGGCCCAGGTTCTACTAGCTCTACTGCTGAATCTCCGGGTCCAGGTTCTACCAGCTCTACTGCTGAATCTCCTGGTCCAGGTACCTCCCCGAGCGGTGAATCTTCTACTGCACCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACCAGCGAATCTCCGTCTGGCACTGCACCAGGTACCTCTACCCCTGAAAGCGGTCCXXXXXXXXXXXXTGCAAGCGCAAGCGGCGCGCCAAGCACGGGAXXXXXXXXTAGCGAATCTCCTTCTGGTACCGCTCCAGGTTCTACCAGCGAATCCCCGTCTGGTACTGCTCCAGGTTCTACCAGCGAATCTCCTTCTGGTACTGCACCAGGTTCTACTAGCGAATCTCCTTCTGGTACCGCTCCAGGTTCTACCAGCGAATCCCCGTCTGGTACTGCTCCAGGTTCTACCAGCGAATCTCCTTCTGGTACTGCACCAGGTACTTCTACTCCGGAAAGCGGTTCCGCATCTCCAGGTACTTCTCCTAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACTGCTCCAGGTTCTACCAGCTCTACTGCTGAATCTCCGGGTCCAGGTACTTCCCCGAGCGGTGAATCTTCTACTGCACCAGGTACTTCTACTCCGGAAAGCGGTTCCGCTTCTCCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCACCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTACCCCGGAAAGCGGCTCTGCTTCTCCAGGTACTTCTACCCCGGAAAGCGGCTCCGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGTACCGCTCCAGGTACTTCTACCCCTGAAAGCGGCTCCGCTTCTCCAGGTTCCACTAGCTCTACCGCTGAATCTCCGGGTCCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCACCAGGTTCTACCAGCTCTACTGCTGAATCTCCGGGTCCAGGTACTTCCCCGAGCGGTGAATCTTCTACTGCACCAGGTACTTCTACTCCGGAAAGCGGTTCCGCTTCTCCAGGTACCTCCCCTAGCGGCGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTACCTCCCCTAGCGGTGAATCTTCTACCGCACCAGGTTCTACTAGCTCTACTGCTGAATCTCCGGGTCCAGGTTCTACCAGCTCTACTGCTGAATCTCCTGGTCCAGGTACCTCCCCGAGCGGTGAATCTTCTACTGCACCAGGTTCTAGCCCTTCTGCTTCCACCGGTACCGGCCCAGGTAGCTCTACTCCGTCTGGTGCAACTGGCTCTCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCA XXXX 插入兩個無序列資訊之區域。 |
AG864 | 255 | GGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTTCTAGCCCGTCTGCTTCTACTGGTACTGGTCCAGGTTCTAGCCCTTCTGCTTCCACTGGTACTGGTCCAGGTACCCCGGGTAGCGGTACCGCTTCTTCTTCTCCAGGTAGCTCTACTCCGTCTGGTGCTACCGGCTCTCCAGGTTCTAACCCTTCTGCATCCACCGGTACCGGCCCAGGTGCTTCTCCGGGCACCAGCTCTACTGGTTCTCCAGGTACCCCGGGCAGCGGTACCGCATCTTCTTCTCCAGGTAGCTCTACTCCTTCTGGTGCAACTGGTTCTCCAGGTACTCCTGGCAGCGGTACCGCTTCTTCTTCTCCAGGTGCTTCTCCTGGTACTAGCTCTACTGGTTCTCCAGGTGCTTCTCCGGGCACTAGCTCTACTGGTTCTCCAGGTACCCCGGGTAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCAACCGGCTCTCCAGGTGCTTCTCCGGGCACCAGCTCTACCGGTTCTCCAGGTACCCCGGGTAGCGGTACCGCTTCTTCTTCTCCAGGTAGCTCTACTCCGTCTGGTGCTACCGGCTCTCCAGGTTCTAACCCTTCTGCATCCACCGGTACCGGCCCAGGTTCTAGCCCTTCTGCTTCCACCGGTACTGGCCCAGGTAGCTCTACCCCTTCTGGTGCTACCGGCTCCCCAGGTAGCTCTACTCCTTCTGGTGCAACTGGCTCTCCAGGTGCATCTCCGGGCACTAGCTCTACTGGTTCTCCAGGTGCATCCCCTGGCACTAGCTCTACTGGTTCTCCAGGTGCTTCTCCTGGTACCAGCTCTACTGGTTCTCCAGGTACTCCTGGCAGCGGTACCGCTTCTTCTTCTCCAGGTGCTTCTCCTGGTACTAGCTCTACTGGTTCTCCAGGTGCTTCTCCGGGCACTAGCTCTACTGGTTCTCCAGGTGCTTCCCCGGGCACTAGCTCTACCGGTTCTCCAGGTTCTAGCCCTTCTGCATCTACTGGTACTGGCCCAGGTACTCCGGGCAGCGGTACTGCTTCTTCCTCTCCAGGTGCATCTCCGGGCACTAGCTCTACTGGTTCTCCAGGTGCATCCCCTGGCACTAGCTCTACTGGTTCTCCAGGTGCTTCTCCTGGTACCAGCTCTACTGGTTCTCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGTTCCCCAGGTAGCTCTACTCCTTCTGGTGCTACTGGCTCCCCAGGTGCATCCCCTGGCACCAGCTCTACCGGTTCTCCAGGTACCCCGGGCAGCGGTACCGCATCTTCCTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACCGGTTCCCCAGGTAGCTCTACCCCGTCTGGTGCAACCGGCTCCCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTTCTAGCCCGTCTGCTTCCACTGGTACTGGCCCAGGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTGCATCCCCGGGTACCAGCTCTACCGGTTCTCCAGGTACTCCTGGCAGCGGTACTGCATCTTCCTCTCCAGGTGCTTCTCCGGGCACCAGCTCTACTGGTTCTCCAGGTGCATCTCCGGGCACTAGCTCTACTGGTTCTCCAGGTGCATCCCCTGGCACTAGCTCTACTGGTTCTCCAGGTGCTTCTCCTGGTACCAGCTCTACTGGTTCTCCAGGTACCCCTGGTAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACTCCGTCTGGTGCTACCGGTTCTCCAGGTACCCCGGGTAGCGGTACCGCATCTTCTTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGTTCTCCAGGTACTCCGGGCAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCTACTGGCTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGCTCCCCAGGTTCTAGCCCTTCTGCATCCACCGGTACCGGTCCAGGTTCTAGCCCGTCTGCATCTACTGGTACTGGTCCAGGTGCATCCCCGGGCACTAGCTCTACCGGTTCTCCAGGTACTCCTGGTAGCGGTACTGCTTCTTCTTCTCCAGGTAGCTCTACTCCTTCTGGTGCTACTGGTTCTCCAGGTTCTAGCCCTTCTGCATCCACCGGTACCGGCCCAGGTTCTAGCCCGTCTGCTTCTACCGGTACTGGTCCAGGTGCTTCTCCGGGTACTAGCTCTACTGGTTCTCCAGGTGCATCTCCTGGTACTAGCTCTACTGGTTCTCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCTCCAGGTTCTAGCCCTTCTGCATCTACCGGTACTGGTCCAGGTGCATCCCCTGGTACCAGCTCTACCGGTTCTCCAGGTTCTAGCCCTTCTGCTTCTACCGGTACCGGTCCAGGTACCCCTGGCAGCGGTACCGCATCTTCCTCTCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGTTCCCCAGGTAGCTCTACTCCTTCTGGTGCTACTGGCTCCCCAGGTGCATCCCCTGGCACCAGCTCTACCGGTTCTCCA |
AM923 | 256 | ATGGCTGAACCTGCTGGCTCTCCAACCTCCACTGAGGAAGGTGCATCCCCGGGCACCAGCTCTACCGGTTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACCGGCTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGCTCTCCAGGTACTTCTACTGAACCGTCTGAAGGCAGCGCACCAGGTAGCGAACCGGCTACTTCCGGTTCTGAAACCCCAGGTAGCCCAGCAGGTTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACTAGCGAATCCCCGTCTGGTACTGCTCCAGGTACTTCTACTCCTGAAAGCGGTTCCGCTTCTCCAGGTACCTCTACTCCGGAAAGCGGTTCTGCATCTCCAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCCGGCCCAGGTAGCCCGGCAGGTTCTCCGACTTCCACTGAGGAAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACCTCTACTGAACCTTCCGAAGGCAGCGCTCCAGGTACCTCTACCGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTACTTCTACTGAACCTTCCGAAGGTAGCGCTCCAGGTAGCGAACCTGCTACTTCTGGTTCTGAAACCCCAGGTAGCCCGGCTGGCTCTCCGACCTCCACCGAGGAAGGTAGCTCTACCCCGTCTGGTGCTACTGGTTCTCCAGGTACTCCGGGCAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCTACTGGCTCTCCAGGTACCTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACTCCAGGTAGCCCTGCTGGCTCTCCGACTTCTACTGAGGAAGGTAGCCCGGCTGGTTCTCCGACTTCTACTGAGGAAGGTACTTCTACCGAACCTTCCGAAGGTAGCGCTCCAGGTGCAAGCGCAAGCGGCGCGCCAAGCACGGGAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCTGAATCTCCTGGCCCAGGTTCTACTAGCGAATCTCCGTCTGGCACCGCACCAGGTACTTCCCCTAGCGGTGAATCTTCTACTGCACCAGGTACCCCTGGCAGCGGTACCGCTTCTTCCTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGCTCTCCAGGTTCTAGCCCGTCTGCATCTACCGGTACCGGCCCAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACTCCAGGTACTTCTGAAAGCGCTACTCCGGAATCCGGCCCAGGTAGCGAACCGGCTACTTCCGGCTCTGAAACCCCAGGTTCCACCAGCTCTACTGCAGAATCTCCGGGCCCAGGTTCTACTAGCTCTACTGCAGAATCTCCGGGTCCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTAGCGAACCGGCAACCTCTGGCTCTGAAACTCCAGGTAGCGAACCTGCAACCTCCGGCTCTGAAACCCCAGGTACTTCTACTGAACCTTCTGAGGGCAGCGCACCAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTACTTCTACCGAACCGTCCGAAGGCAGCGCTCCAGGTACCTCTACTGAACCTTCCGAGGGCAGCGCTCCAGGTACCTCTACCGAACCTTCTGAAGGTAGCGCACCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTTCTAGCCCGTCTGCTTCCACTGGTACTGGCCCAGGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTAGCGAACCTGCTACCTCCGGTTCTGAAACCCCAGGTACCTCTGAAAGCGCAACTCCGGAGTCTGGTCCAGGTAGCCCTGCAGGTTCTCCTACCTCCACTGAGGAAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTTCTAGCCCGTCTGCTTCCACTGGTACTGGCCCAGGTGCTTCCCCGGGCACCAGCTCTACTGGTTCTCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCA |
AE912 | 257 | ATGGCTGAACCTGCTGGCTCTCCAACCTCCACTGAGGAAGGTACCCCGGGTAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCAACCGGCTCTCCAGGTGCTTCTCCGGGCACCAGCTCTACCGGTTCTCCAGGTAGCCCGGCTGGCTCTCCTACCTCTACTGAGGAAGGTACTTCTGAAAGCGCTACTCCTGAGTCTGGTCCAGGTACCTCTACTGAACCGTCCGAAGGTAGCGCTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTAGCGAACCGGCTACTTCTGGCTCTGAGACTCCAGGTACTTCTACCGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACTGAACCGTCTGAAGGTAGCGCACCAGGTACTTCTGAAAGCGCAACCCCGGAATCCGGCCCAGGTACCTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAAGGCAGCGCTCCAGGTACCTCTACTGAACCTTCCGAGGGCAGCGCTCCAGGTACCTCTACCGAACCTTCTGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTACCTCTGAAAGCGCAACTCCTGAGTCTGGCCCAGGTAGCGAACCTGCTACCTCCGGCTCTGAGACTCCAGGTACCTCTGAAAGCGCAACCCCGGAATCTGGTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACTTCTGAAAGCGCTACCCCGGAATCTGGCCCAGGTAGCGAACCGGCTACTTCTGGTTCTGAAACCCCAGGTAGCGAACCGGCTACCTCCGGTTCTGAAACTCCAGGTAGCCCAGCAGGCTCTCCGACTTCCACTGAGGAAGGTACTTCTACTGAACCTTCCGAAGGCAGCGCACCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTAGCGAACCTGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCTGGCCCAGGTACTTCTACTGAACCGTCCGAGGGCAGCGCACCA |
AM1296 | 258 | GGTACTTCTACTGAACCGTCTGAAGGCAGCGCACCAGGTAGCGAACCGGCTACTTCCGGTTCTGAAACCCCAGGTAGCCCAGCAGGTTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCAGAATCTCCTGGTCCAGGTACCTCTACTCCGGAAAGCGGCTCTGCATCTCCAGGTTCTACTAGCGAATCTCCTTCTGGCACTGCACCAGGTTCTACTAGCGAATCCCCGTCTGGTACTGCTCCAGGTACTTCTACTCCTGAAAGCGGTTCCGCTTCTCCAGGTACCTCTACTCCGGAAAGCGGTTCTGCATCTCCAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCCGGCCCAGGTAGCCCGGCAGGTTCTCCGACTTCCACTGAGGAAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTACCTCTACTGAACCTTCCGAAGGCAGCGCTCCAGGTACCTCTACCGAACCGTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTACTTCTACTGAACCTTCCGAAGGTAGCGCTCCAGGTAGCGAACCTGCTACTTCTGGTTCTGAAACCCCAGGTAGCCCGGCTGGCTCTCCGACCTCCACCGAGGAAGGTAGCTCTACCCCGTCTGGTGCTACTGGTTCTCCAGGTACTCCGGGCAGCGGTACTGCTTCTTCCTCTCCAGGTAGCTCTACCCCTTCTGGTGCTACTGGCTCTCCAGGTACCTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACTCCAGGTAGCCCTGCTGGCTCTCCGACTTCTACTGAGGAAGGTAGCCCGGCTGGTTCTCCGACTTCTACTGAGGAAGGTACTTCTACCGAACCTTCCGAAGGTAGCGCTCCAGGTCCAGAACCAACGGGGCCGGCCCCAAGCGGAGGTAGCGAACCGGCAACCTCCGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCTGAATCCGGCCCAGGTAGCCCGGCAGGTTCTCCGACTTCCACTGAGGAAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTACTTCTGAAAGCGCTACTCCTGAGTCCGGCCCAGGTAGCCCGGCTGGCTCTCCGACTTCCACCGAGGAAGGTAGCCCGGCTGGCTCTCCAACTTCTACTGAAGAAGGTTCTACCAGCTCTACCGCTGAATCTCCTGGCCCAGGTTCTACTAGCGAATCTCCGTCTGGCACCGCACCAGGTACTTCCCCTAGCGGTGAATCTTCTACTGCACCAGGTTCTACCAGCGAATCTCCTTCTGGCACCGCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACCGCACCAGGTACTTCTCCTAGCGGCGAATCTTCTACCGCACCAGGTACTTCTACCGAACCTTCCGAGGGCAGCGCACCAGGTACTTCTGAAAGCGCTACCCCTGAGTCCGGCCCAGGTACTTCTGAAAGCGCTACTCCTGAATCCGGTCCAGGTAGCGAACCGGCAACCTCTGGCTCTGAAACCCCAGGTACCTCTGAAAGCGCTACTCCGGAATCTGGTCCAGGTACTTCTGAAAGCGCTACTCCGGAATCCGGTCCAGGTACCTCTACTGAACCTTCTGAGGGCAGCGCTCCAGGTACTTCTGAAAGCGCTACCCCGGAGTCCGGTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTACCTCCCCTAGCGGCGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACCGCTCCAGGTACCTCCCCTAGCGGTGAATCTTCTACCGCACCAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTAGCCCAGCAGGTTCTCCTACCTCCACCGAGGAAGGTACTTCTACCGAACCGTCCGAGGGTAGCGCACCAGGTTCTAGCCCTTCTGCTTCCACCGGTACCGGCCCAGGTAGCTCTACTCCGTCTGGTGCAACTGGCTCTCCAGGTAGCTCTACTCCGTCTGGTGCAACCGGCTCCCCAGGTAGCTCTACCCCGTCTGGTGCTACCGGCTCTCCAGGTAGCTCTACCCCGTCTGGTGCAACCGGCTCCCCAGGTGCATCCCCGGGTACTAGCTCTACCGGTTCTCCAGGTGCAAGCGCAAGCGGCGCGCCAAGCACGGGAGGTACTTCTCCGAGCGGTGAATCTTCTACCGCACCAGGTTCTACTAGCTCTACCGCTGAATCTCCGGGCCCAGGTACTTCTCCGAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTGAAAGCGCTACTCCGGAGTCTGGCCCAGGTACCTCTACTGAACCGTCTGAGGGTAGCGCTCCAGGTACTTCTACTGAACCGTCCGAAGGTAGCGCACCAGGTTCTAGCCCTTCTGCATCTACTGGTACTGGCCCAGGTAGCTCTACTCCTTCTGGTGCTACCGGCTCTCCAGGTGCTTCTCCGGGTACTAGCTCTACCGGTTCTCCAGGTACTTCTACTCCGGAAAGCGGTTCCGCATCTCCAGGTACTTCTCCTAGCGGTGAATCTTCTACTGCTCCAGGTACCTCTCCTAGCGGCGAATCTTCTACTGCTCCAGGTACTTCTGAAAGCGCAACCCCTGAATCCGGTCCAGGTAGCGAACCGGCTACTTCTGGCTCTGAGACTCCAGGTACTTCTACCGAACCGTCCGAAGGTAGCGCACCAGGTTCTACCAGCGAATCCCCTTCTGGTACTGCTCCAGGTTCTACCAGCGAATCCCCTTCTGGCACCGCACCAGGTACTTCTACCCCTGAAAGCGGCTCCGCTTCTCCAGGTAGCCCGGCAGGCTCTCCGACCTCTACTGAGGAAGGTACTTCTGAAAGCGCAACCCCGGAGTCCGGCCCAGGTACCTCTACCGAACCGTCTGAGGGCAGCGCACCAGGTAGCCCTGCTGGCTCTCCAACCTCCACCGAAGAAGGTACCTCTGAAAGCGCAACCCCTGAATCCGGCCCAGGTAGCGAACCGGCAACCTCCGGTTCTGAAACCCCAGGTAGCTCTACCCCGTCTGGTGCTACCGGTTCCCCAGGTGCTTCTCCTGGTACTAGCTCTACCGGTTCTCCAGGTAGCTCTACCCCGTCTGGTGCTACTGGCTCTCCAGGTTCTACTAGCGAATCCCCGTCTGGTACTGCTCCAGGTACTTCCCCTAGCGGTGAATCTTCTACTGCTCCAGGTTCTACCAGCTCTACCGCAGAATCTCCGGGTCCAGGTAGCTCTACCCCTTCTGGTGCAACCGGCTCTCCAGGTGCATCCCCGGGTACCAGCTCTACCGGTTCTCCAGGTACTCCGGGTAGCGGTACCGCTTCTTCCTCTCCAGGTAGCCCTGCTGGCTCTCCGACTTCTACTGAGGAAGGTAGCCCGGCTGGTTCTCCGACTTCTACTGAGGAAGGTACTTCTACCGAACCTTCCGAAGGTAGCGCTCCA |
BC864 | 259 | GGTACTTCCACCGAACCATCCGAACCAGGTAGCGCAGGTACTTCCACCGAACCATCCGAACCTGGCAGCGCAGGTAGCGAACCGGCAACCTCTGGTACTGAACCATCAGGTAGCGGCGCATCCGAGCCTACCTCTACTGAACCAGGTAGCGAACCGGCTACCTCCGGTACTGAGCCATCAGGTAGCGAACCGGCAACTTCCGGTACTGAACCATCAGGTAGCGAACCGGCAACTTCCGGCACTGAACCATCAGGTAGCGGTGCATCTGAGCCGACCTCTACTGAACCAGGTACTTCTACTGAACCATCTGAGCCGGGCAGCGCAGGTAGCGAACCAGCTACTTCTGGCACTGAACCATCAGGTACTTCTACTGAACCATCCGAACCAGGTAGCGCAGGTAGCGAACCTGCTACCTCTGGTACTGAGCCATCAGGTAGCGAACCGGCTACCTCTGGTACTGAACCATCAGGTACTTCTACCGAACCATCCGAGCCTGGTAGCGCAGGTACTTCTACCGAACCATCCGAGCCAGGCAGCGCAGGTAGCGAACCGGCAACCTCTGGCACTGAGCCATCAGGTAGCGAACCAGCAACTTCTGGTACTGAACCATCAGGTACTAGCGAGCCATCTACTTCCGAACCAGGTGCAGGTAGCGGCGCATCCGAACCTACTTCCACTGAACCAGGTACTAGCGAGCCATCCACCTCTGAACCAGGTGCAGGTAGCGAACCGGCAACTTCCGGCACTGAACCATCAGGTAGCGAACCGGCTACCTCTGGTACTGAACCATCAGGTACTTCTACCGAACCATCCGAGCCTGGTAGCGCAGGTACTTCTACCGAACCATCCGAGCCAGGCAGCGCAGGTAGCGGTGCATCCGAGCCGACCTCTACTGAACCAGGTAGCGAACCAGCAACTTCTGGCACTGAGCCATCAGGTAGCGAACCAGCTACCTCTGGTACTGAACCATCAGGTAGCGAACCGGCTACTTCCGGCACTGAACCATCAGGTAGCGAACCAGCAACCTCCGGTACTGAACCATCAGGTACTTCCACTGAACCATCCGAACCGGGTAGCGCAGGTAGCGAACCGGCAACTTCCGGCACTGAACCATCAGGTAGCGGTGCATCTGAGCCGACCTCTACTGAACCAGGTACTTCTACTGAACCATCTGAGCCGGGCAGCGCAGGTAGCGAACCTGCAACCTCCGGCACTGAGCCATCAGGTAGCGGCGCATCTGAACCAACCTCTACTGAACCAGGTACTTCCACCGAACCATCTGAGCCAGGCAGCGCAGGTAGCGGCGCATCTGAACCAACCTCTACTGAACCAGGTAGCGAACCAGCAACTTCTGGTACTGAACCATCAGGTAGCGGCGCATCTGAGCCTACTTCCACTGAACCAGGTAGCGAACCGGCAACTTCCGGCACTGAACCATCAGGTAGCGGTGCATCTGAGCCGACCTCTACTGAACCAGGTACTTCTACTGAACCATCTGAGCCGGGCAGCGCAGGTAGCGAACCGGCAACTTCCGGCACTGAACCATCAGGTAGCGGTGCATCTGAGCCGACCTCTACTGAACCAGGTACTTCTACTGAACCATCTGAGCCGGGCAGCGCAGGTAGCGAACCAGCTACTTCTGGCACTGAACCATCAGGTACTTCTACTGAACCATCCGAACCAGGTAGCGCAGGTAGCGAACCTGCTACCTCTGGTACTGAGCCATCAGGTACTTCTACTGAACCATCCGAGCCGGGTAGCGCAGGTACTTCCACTGAACCATCTGAACCTGGTAGCGCAGGTACTTCCACTGAACCATCCGAACCAGGTAGCGCAGGTACTTCTACTGAACCATCCGAGCCGGGTAGCGCAGGTACTTCCACTGAACCATCTGAACCTGGTAGCGCAGGTACTTCCACTGAACCATCCGAACCAGGTAGCGCAGGTACTAGCGAACCATCCACCTCCGAACCAGGCGCAGGTAGCGGTGCATCTGAACCGACTTCTACTGAACCAGGTACTTCCACTGAACCATCTGAGCCAGGTAGCGCAGGTACTTCCACCGAACCATCCGAACCAGGTAGCGCAGGTACTTCCACCGAACCATCCGAACCTGGCAGCGCAGGTAGCGAACCGGCAACCTCTGGTACTGAACCATCAGGTAGCGGTGCATCCGAGCCGACCTCTACTGAACCAGGTAGCGAACCAGCAACTTCTGGCACTGAGCCATCAGGTAGCGAACCAGCTACCTCTGGTACTGAACCATCAGGTAGCGAACCGGCAACCTCTGGCACTGAGCCATCAGGTAGCGAACCAGCAACTTCTGGTACTGAACCATCAGGTACTAGCGAGCCATCTACTTCCGAACCAGGTGCAGGTAGCGAACCTGCAACCTCCGGCACTGAGCCATCAGGTAGCGGCGCATCTGAACCAACCTCTACTGAACCAGGTACTTCCACCGAACCATCTGAGCCAGGCAGCGCAGGTAGCGAACCTGCAACCTCCGGCACTGAGCCATCAGGTAGCGGCGCATCTGAACCAACCTCTACTGAACCAGGTACTTCCACCGAACCATCTGAGCCAGGCAGCGCA |
BD864 | 260 | GGTAGCGAAACTGCTACTTCCGGCTCTGAGACTGCAGGTACTAGTGAATCCGCAACTAGCGAATCTGGCGCAGGTAGCACTGCAGGCTCTGAGACTTCCACTGAAGCAGGTACTAGCGAGTCCGCAACCAGCGAATCCGGCGCAGGTAGCGAAACTGCTACCTCTGGCTCCGAGACTGCAGGTAGCGAAACTGCAACCTCTGGCTCTGAAACTGCAGGTACTTCCACTGAAGCAAGTGAAGGCTCCGCATCAGGTACTTCCACCGAAGCAAGCGAAGGCTCCGCATCAGGTACTAGTGAGTCCGCAACTAGCGAATCCGGTGCAGGTAGCGAAACCGCTACCTCTGGTTCCGAAACTGCAGGTACTTCTACCGAGGCTAGCGAAGGTTCTGCATCAGGTAGCACTGCTGGTTCCGAGACTTCTACTGAAGCAGGTACTAGCGAATCTGCTACTAGCGAATCCGGCGCAGGTACTAGCGAATCCGCTACCAGCGAATCCGGCGCAGGTAGCGAAACTGCAACCTCTGGTTCCGAGACTGCAGGTACTAGCGAGTCCGCTACTAGCGAATCTGGCGCAGGTACTTCCACTGAAGCTAGTGAAGGTTCTGCATCAGGTAGCGAAACTGCTACTTCTGGTTCCGAAACTGCAGGTAGCGAAACCGCTACCTCTGGTTCCGAAACTGCAGGTACTTCTACCGAGGCTAGCGAAGGTTCTGCATCAGGTAGCACTGCTGGTTCCGAGACTTCTACTGAAGCAGGTACTAGCGAGTCCGCTACTAGCGAATCTGGCGCAGGTACTTCCACTGAAGCTAGTGAAGGTTCTGCATCAGGTAGCGAAACTGCTACTTCTGGTTCCGAAACTGCAGGTAGCACTGCTGGCTCCGAGACTTCTACCGAAGCAGGTAGCACTGCAGGTTCCGAAACTTCCACTGAAGCAGGTAGCGAAACTGCTACCTCTGGCTCTGAGACTGCAGGTACTAGCGAATCTGCTACTAGCGAATCCGGCGCAGGTACTAGCGAATCCGCTACCAGCGAATCCGGCGCAGGTAGCGAAACTGCAACCTCTGGTTCCGAGACTGCAGGTACTAGCGAATCTGCTACTAGCGAATCCGGCGCAGGTACTAGCGAATCCGCTACCAGCGAATCCGGCGCAGGTAGCGAAACTGCAACCTCTGGTTCCGAGACTGCAGGTAGCGAAACCGCTACCTCTGGTTCCGAAACTGCAGGTACTTCTACCGAGGCTAGCGAAGGTTCTGCATCAGGTAGCACTGCTGGTTCCGAGACTTCTACTGAAGCAGGTAGCGAAACTGCTACTTCCGGCTCTGAGACTGCAGGTACTAGTGAATCCGCAACTAGCGAATCTGGCGCAGGTAGCACTGCAGGCTCTGAGACTTCCACTGAAGCAGGTAGCACTGCTGGTTCCGAAACCTCTACCGAAGCAGGTAGCACTGCAGGTTCTGAAACCTCCACTGAAGCAGGTACTTCCACTGAGGCTAGTGAAGGCTCTGCATCAGGTAGCACTGCTGGTTCCGAAACCTCTACCGAAGCAGGTAGCACTGCAGGTTCTGAAACCTCCACTGAAGCAGGTACTTCCACTGAGGCTAGTGAAGGCTCTGCATCAGGTAGCACTGCAGGTTCTGAGACTTCCACCGAAGCAGGTAGCGAAACTGCTACTTCTGGTTCCGAAACTGCAGGTACTTCCACTGAAGCTAGTGAAGGTTCCGCATCAGGTACTAGTGAGTCCGCAACCAGCGAATCCGGCGCAGGTAGCGAAACCGCAACCTCCGGTTCTGAAACTGCAGGTACTAGCGAATCCGCAACCAGCGAATCTGGCGCAGGTACTAGTGAGTCCGCAACCAGCGAATCCGGCGCAGGTAGCGAAACCGCAACCTCCGGTTCTGAAACTGCAGGTACTAGCGAATCCGCAACCAGCGAATCTGGCGCAGGTAGCGAAACTGCTACTTCCGGCTCTGAGACTGCAGGTACTTCCACCGAAGCAAGCGAAGGTTCCGCATCAGGTACTTCCACCGAGGCTAGTGAAGGCTCTGCATCAGGTAGCACTGCTGGCTCCGAGACTTCTACCGAAGCAGGTAGCACTGCAGGTTCCGAAACTTCCACTGAAGCAGGTAGCGAAACTGCTACCTCTGGCTCTGAGACTGCAGGTACTAGCGAATCTGCTACTAGCGAATCCGGCGCAGGTACTAGCGAATCCGCTACCAGCGAATCCGGCGCAGGTAGCGAAACTGCAACCTCTGGTTCCGAGACTGCAGGTAGCGAAACTGCTACTTCCGGCTCCGAGACTGCAGGTAGCGAAACTGCTACTTCTGGCTCCGAAACTGCAGGTACTTCTACTGAGGCTAGTGAAGGTTCCGCATCAGGTACTAGCGAGTCCGCAACCAGCGAATCCGGCGCAGGTAGCGAAACTGCTACCTCTGGCTCCGAGACTGCAGGTAGCGAAACTGCAACCTCTGGCTCTGAAACTGCAGGTACTAGCGAATCTGCTACTAGCGAATCCGGCGCAGGTACTAGCGAATCCGCTACCAGCGAATCCGGCGCAGGTAGCGAAACTGCAACCTCTGGTTCCGAGACTGCA |
可將XTEN編碼基因庫選殖至此項技術中已知之一或多種表現載體中。為了促進表現良好之庫成員之鑑別,可以將庫構築作為與報導蛋白之融合物。適合報導基因之非限制性實例為綠色螢光蛋白、螢光素酶、鹼性磷酸酶及β-半乳糖苷酶。藉由篩檢,吾人可鑑別可在所選宿主生物體中以高濃度表現之短XTEN序列。隨後,可產生隨機XTEN二聚體之庫且針對高表現量重複篩選。隨後,吾人可針對多種特性,諸如表現量、蛋白酶穩定性或與抗血清之結合來篩選所得構築體。
本發明之一個態樣係提供編碼融合蛋白之組分的聚核苷酸序列,其中序列之產生已進行密碼子最佳化。備受關注的係密碼子最佳化,其以改良多肽組合物之表現及改良編碼基因在生產宿主中之基因穩定性為目標。舉例而言,密碼子最佳化對於富含甘胺酸或具有極重複胺基酸序列之XTEN序列尤其重要。可使用電腦程式執行密碼子最佳化(Gustafsson, C.等人, (2004)
Trends Biotechnol,
22: 346-53),其中一些使核糖體暫停最小化(Coda基因體學公司)。在一個實施例中,可藉由構築密碼子庫來進行密碼子最佳化,其中庫之所有成員編碼相同胺基酸序列,但密碼子使用不同。此類庫可經篩選為高度表現及遺傳穩定之成員,尤其為適合於大規模生產含XTEN之產品。當設計XTEN序列時,可考慮多種特性。吾人可將編碼DNA序列中之重複性最小化。此外,可避免或最小化生產宿主很少使用之密碼子(例如
大腸桿菌中之AGG及AGA精胺酸密碼子及一種白胺酸密碼子)的使用。在
大腸桿菌之情況下,兩種甘胺酸密碼子GGA及GGG很少用於高度表現之蛋白質中。因此,編碼XTEN序列之基因的密碼子最佳化可為極其合乎需要的。具有高水準甘胺酸之DNA序列往往會具有高GC含量,其可能導致不穩定性或低表現量。因此,當可能時,較佳選擇密碼子以使XTEN編碼序列之GC含量適合於生產將用於製造XTEN的生物體。
視情況,全長XTEN編碼基因可包含一或多個定序島。在此情形下,定序島為矮拉伸序列,其與XTEN庫構築體序列不同且包括全長XTEN編碼基因中不存在或預期存在之限制位點。在一個實施例中,定序島為序列
5'-AGGTGCAAGCGCAAGCGGCGCGCCAAGCACGGGAGGT-3'(SEQ ID NO: 261)。在另一實施例中,定序島為序列
5'-AGGTCCAGAACCAACGGGGCCGGCCCCAAGCGGAGGT-3'(SEQ ID NO: 262)。
作為替代方案,吾人可構築密碼子庫,其中庫之所有成員編碼相同胺基酸序列,但其中密碼子使用不同。此類庫可經篩選為高度表現及遺傳穩定之成員,尤其為適合於大規模生產含XTEN之產品。
視情況,可在庫中對純系進行定序以消除含有不合需要之序列的分離株。短XTEN序列之初始庫可允許胺基酸序列發生一些變化。舉例而言,可將一些密碼子隨機化以使得多個親水性胺基酸可出現在特定位置。
在迭代多聚化過程期間,除篩選高水準表現以外,吾人可篩選所得庫成員之其他特徵,如溶解性或蛋白酶抗性。
一旦選擇編碼具有所需長度及特性之XTEN的基因,則藉由將其選殖至與編碼BP或鄰接於間隔子序列之基因相鄰且同框的構築體中而基因融合至編碼BP基因之N端及/或C端的核苷酸。本發明提供前述之各種排列,視待編碼之BPXTEN而定。舉例而言,如上文所描繪之編碼包含諸如藉由式III或IV體現之兩種BP之BPXTEN融合蛋白的基因,該基因將具有編碼兩種BP之聚核苷酸、至少第一XTEN及視情況存在之第二XTEN及/或間隔子序列。BP基因選殖至XTEN構築體中之步驟可經由接合或多聚化步驟進行。如
圖 2 A- 圖 2 G中所示,編碼BPXTEN融合蛋白之構築體可經設計成組分
202、BP
203及間隔子序列
204 之不同組態。在一個實施例中,如
圖 2 A中所示,構築體包含與以下次序(5'至3')BP
203及XTEN
202或反向次序之組分的單體多肽互補的聚核苷酸序列或編碼該等組分之單體多肽的聚核苷酸序列。在另一實施例中,如
圖 2 B中所示,構築體包含與以下次序(5'至3')BP
203、間隔子序列
204及XTEN
202或反向次序之組分的單體多肽互補的聚核苷酸序列或編碼該等組分之單體多肽的聚核苷酸序列。在另一實施例中,如
圖 2 C中所示,構築體
201編碼單體BPXTEN,該單體BPXTEN包含與以下次序(5'至3'):兩個BP分子
203及XTEN
202或反向次序
之組分互補的聚核苷酸序列或編碼該等組分的聚核苷酸序列。在另一實施例中,如
圖 2 D中所示,構築體包含與以下次序(5'至3'):兩個BP分子
203、間隔子序列
204及XTEN
202或反向次序之組分的單體多肽互補的聚核苷酸序列或編碼該等組分之單體多肽的聚核苷酸序列。在另一實施例中,如
圖 2 E中所示,構築體包含與以下次序(5'至3'):BP
203、間隔子序列
204 、BP
203之第二分子及XTEN
202或反向次序之組分的單體多肽互補的聚核苷酸序列或編碼該等組分之單體多肽的聚核苷酸序列。在另一實施例中,如
圖 2 F中所示,構築體包含與以下次序(5'至3'):BP
203、XTEN
202、BP
203及第二XTEN
202或反向次序之組分的單體多肽互補的聚核苷酸序列或編碼該等組分之單體多肽的聚核苷酸序列。間隔子聚核苷酸可視情況包含編碼裂解序列之序列。如熟習此項技術者將顯而易見,前述內容之其他排列係可能的。
本發明亦涵蓋包含XTEN編碼聚核苷酸變異體之聚核苷酸,該等聚核苷酸變異體與(a)來自
表 8之聚核苷酸序列或(b)與(a)之聚核苷酸互補的序列具有高百分比之序列一致性。具有高百分比序列一致性的聚核苷酸係指與前述(a)或(b)具有至少約為80%核酸序列一致性,或者至少約81%、或者至少約82%、或者至少約83%、或者至少約84%、或者至少約85%、或者至少約86%、或者至少約87%、或者至少約88%、或者至少約89%、或者至少約90%、或者至少約91%、或者至少約92%、或者至少約93%、或者至少約94%、或者至少約95%、或者至少約96%、或者至少約97%、或者至少約98%及或者至少約99%核酸序列一致性的聚核苷酸,或在嚴格條件下能與目標聚核苷酸或其補體進行雜交。
核苷酸或胺基酸序列之同源性、序列相似性或序列一致性亦可習知地藉由使用已知軟體或電腦程式,諸如BestFit或Gap成對比較程式(GCG Wisconsin Package, Genetics Computer Group, 575 Science Drive, Madison, Wis. 53711)來確定。BestFit使用Smith及Waterman的局部同源性演算法(Advances in Applied Mathematics. 1981. 2: 482-489),以發現兩個序列之間的一致性或相似性之最佳區段。Gap進行全局比對:使用Needleman及Wunsch的方法,將一個序列與另一個相似序列進行比對(Journal of Molecular Biology. 1970. 48:443-453)。當使用諸如BestFit之序列比對程式以確定序列同源性、相似性或一致性之程度時,可以使用預設設置,或可以選擇適當的計分矩陣以使一致性、相似性或同源性分數最佳化。
「互補」之核酸序列係能夠根據標準沃森-克里克(Watson-Crick)互補規則進行鹼基配對的彼等核酸序列。如本文所用,術語「互補序列」意指實質上互補的核酸序列,如上文所描述,可藉由相同的上述核苷酸進行比較評估,或如定義為能夠在嚴格條件下與編碼BPXTEN序列之聚核苷酸雜交,諸如本文所描述之彼等物。
編碼BPXTEN嵌合組合物之所得聚核苷酸可隨後個別地選殖至表現載體中。核酸序列可藉由多種程序插入至載體中。一般而言,DNA係使用此項技術中已知之技術插入至適當限制性核酸內切酶位點中。載體組分一般包括但不限於以下中之一或多者:信號序列、複製起點、一或多個標記基因、強化子元件、啟動子及轉錄終止序列。含有此等組分中之一或多者之適合之載體的構築採用熟習此項技術者已知之標準連接技術。此類程序為此項技術中熟知且詳盡描述於科學及專利文獻中。
各種載體為公開可用的。載體可例如呈質體、黏質體、病毒粒子或噬菌體形式。表現載體及選殖載體均含有使得載體能夠在一或多種所選宿主細胞中複製的核酸序列。此類載體序列對於各種細菌、酵母菌及病毒而言為熟知的。可用之適用表現載體包括例如染色體、非染色體及合成DNA序列之區段。適合之載體包括但不限於SV40及pcDNA之衍生物及已知細菌質體,諸如col EI、pCRl、pBR322、pMal-C2、pET、pGEX(如由Smith等人, Gene 57:31-40 (1988)所描述)、pMB9及其衍生物;質體,諸如RP4;噬菌體DNA,諸如噬菌體I之諸多衍生物,諸如NM98 9,以及其他噬菌體DNA,諸如M13及絲狀單股噬菌體DNA;酵母菌質體,諸如2微米質體或2 m質體之衍生物,以及著絲粒及整合酵母菌穿梭載體;適用於真核細胞之載體,諸如適用於昆蟲或哺乳動物細胞之載體;衍生自質體及噬菌體DNA之組合的載體,諸如經修飾以採用噬菌體DNA或表現控制序列之質體;及其類似物。要求為載體在所選宿主細胞中為可重複及可存活的。可按需要使用低複本數或高複本數載體。
適合用於原核宿主表現載體之啟動子包括β-內醯胺酶及乳糖啟動子系統[Chang等人, Nature, 275:615 (1978);Goeddel等人, Nature, 281:544 (1979)]、鹼性磷酸酶、色胺酸(trp)啟動子系統[Goeddel, Nucleic Acids Res., 8:4057 (1980);EP 36,776]及雜交啟動子,諸如tac啟動子[deBoer等人, Proc. Natl. Acad. Sci. USA, 80:21-25 (1983)]。用於細菌系統之啟動子亦可含有可操作地連接於編碼BPXTEN多肽之DNA的Shine-Dalgarno(S.D.)序列。
例如,在桿狀病毒表現系統中,可以使用兩種非融合轉移載體,諸如但不限於pVL941(BamHI選殖位點,獲自Summers等人, Virology 84:390-402 (1978))、pVL1393(BamHI、Smal、Xbal、EcoRI、IVotl、Xmalll、BgIII及Pstl選殖位點;Invitrogen)、pVL1392(BgIII、Pstl、NotI、XmaIII、EcoRI、Xball、Smal及BamHI選殖位點;Summers等人, Virology 84:390- 402 (1978)及Invitrogen)及pBlueBacIII(BamHI、BgIII、Pstl、Ncol及Hindi II選殖位點,帶有藍/白重組篩選,Invitrogen),以及融合轉移載體,諸如但不限於:pAc7 00(BamHI及Kpnl選殖位點,其中BamHI識別位點以起始密碼子開始;Summers等人, Virology 84:390- 402 (1978))、pAc701及pAc70-2(與pAc700相同,具有不同閱讀框)、pAc360[BamHI選殖位點,多角體蛋白起始密碼子下游的36個鹼基對;Invitrogen(1995))及pBlueBacHisA、B、C(三個不同的閱讀框,帶有BamH I、BgI II、Pstl、Nco l及Hind III選殖位點,用於ProBond純化及藍/白重組篩選斑塊的N端肽;Invitrogen(220))。
哺乳動物表現載體可包含複製起點、適合的啟動子及強化子以及任何所需核糖體結合位點、聚腺苷酸化位點、剪接供體及受體位點、轉錄終止序列及5'側接非轉錄序列。來源於SV40剪接及聚腺苷酸化位點之DNA序列可用於提供所需非轉錄遺傳元件。預期用於本發明中之哺乳動物表現載體包括具有可誘導型啟動子之載體,諸如二氫葉酸還原酶啟動子、任何帶有DHFR表現卡匣或DHFR/甲胺喋呤共擴增載體之表現載體,諸如pED(Pstl、Sail、Sbal、Smal及EcoRI選殖位點,其中載體表現選殖基因及DHFR兩者,Randal J. Kaufman, 1991, Randal J. Kaufman, Current Protocols in Molecular Biology, 16,12 (1991))。或者,麩醯胺酸合成酶/甲硫胺酸亞碸亞胺共擴增載體,諸如pEE14(Hindlll、Xball、Smal、Sbal、EcoRI及Sell選殖位點,其中載體表現麩醯胺酸合成酶及選殖基因;Celltech)。可以使用在埃-巴二氏病毒(EBV)或核抗原(EBNA)控制下指導游離體表現的載體,諸如pREP4(BamHI r SfH、Xhol、NotI、Nhel、Hindi II、NheI、PvuII及Kpnl選殖位點,構成性RSV-LTR啟動子,潮黴素可選標記;Invitrogen)pCEP4、(BamHI、SfH、Xhol、NotI、Nhel、Hindlll、Nhel、PvuII及Kpnl選殖位點,構成性hCMV即刻早期基因啟動子,潮黴素可選標記;Invitrogen)pMEP4(.Kpnl、Pvul、Nhel、Hindlll、NotI、Xhol、Sfil、BamHI選殖位點,可誘導型甲硫蛋白H a基因啟動子,潮黴素可選標記,Invitrogen)、pREP8(BamHI、Xhol、NotI、Hindlll、Nhel及Kpnl選殖位點,RSV-LTR啟動子,組胺醇可選標記;Invitrogen)、pREP9(Kpnl、Nhel、Hind lll、NotI、Xho l、Sfi l、BamH I選殖位點,RSV-LTR啟動子,G418可選標記;Invitrogen)及pEBVHis(RSV-LTR啟動子,潮黴素可選標記,可經由ProBond樹脂純化以及由腸激酶裂解的N端肽;Invitrogen)。
用於本發明之可選哺乳動物表現載體包括(但不限於)pRc/CMV(Hind lll、BstXI、NotI、Sbal及Apal選殖位點,G418選擇,Invitrogen)、pRc/RSV(Hind II、Spel、BstXI、NotI、Xbal選殖位點,G418選擇,Invitrogen)及其類似物。可用於本發明中之痘瘡病毒哺乳動物表現載體(參見,例如Randall J. Kaufman, Current Protocols in Molecular Biology 16.12 (Frederick M. Ausubel,等人, 編. Wiley 1991)包括(但不限於)pSC11(Smal選殖位點,TK-及β-gal選擇)、pMJ601(Sal l、Sma l、A flI、Narl、BspMlI、BamHI、Apal、Nhel、SacII、Kpnl及Hindlll選殖位點;TK-及-gal選擇)、pTKgptFlS(EcoRI、Pstl、SaIII、Accl、HindII、Sbal、BamHI及Hpa選殖位點,TK或XPRT選擇)等。
亦可用於本發明中之酵母表現系統包括(但不限於)非融合pYES2載體(XJbal、Sphl、Shol、NotI、GstXI、EcoRI、BstXI、BamHI、Sad、Kpnl及Hindlll選殖位點,Invitrogen)、融合pYESHisA、B、C(Xball、Sphl、Shol、NotI、BstXI、EcoRI、BamHI、Sad、Kpnl及Hindi II選殖位點,經樹脂純化以及經腸激酶裂解之N端肽,英傑)、pRS載體等。
另外,含有嵌合BPXTEN融合蛋白編碼聚核苷酸分子之表現載體可包括藥物選擇標記。此類標記有助於選殖及選擇或鑑別含有嵌合DNA分子之載體。舉例而言,賦予針對新黴素、嘌呤黴素、潮黴素、二氫葉酸還原酶(DHFR)抑制劑、鳥嘌呤磷酸核糖基轉移酶(GPT)、吉歐黴素(zeocin)及組胺醇之抗性的基因係有用的可選標記。替代地,可採用酶,諸如疱疹單純型病毒胸苷激酶(tk)或氯黴素乙醯基轉移酶(CAT)。亦可採用免疫標記。可採用任何已知可選標記,只要其能夠與編碼基因產物之核酸同時表現即可。可選標記之其他實例為熟習此項技術者所熟知且包括報導子,諸如增強型綠色螢光蛋白(EGFP)、β-半乳糖苷酶(β-gal)或氯黴素乙醯基轉移酶(CAT)。
在一個實施例中,編碼BPXTEN融合蛋白組合物之聚核苷酸可以C端融合至N端信號序列,其適用於表現宿主系統。信號序列通常在易位及分泌過程期間以蛋白分解方式自蛋白質移除,產生所定義之N端。已描述廣泛多種信號序列用於大部分表現系統,包括細菌、酵母菌、昆蟲及哺乳動物系統。各表現系統之較佳實例之非限制性清單在本文中之後。對於
大腸桿菌表現,較佳信號序列為OmpA、PhoA及DsbA。對於酵母菌表現,較佳之信號肽為ppL-α、DEX4、轉化酶信號肽、酸性磷酸酶信號肽、CPY或INU1。對於昆蟲細胞表現,較佳信號序列為sexta激脂激素前驅體、CP1、CP2、CP3、CP4、TPA、PAP或gp67。對於哺乳動物表現,較佳信號序列為IL2L、SV40、IgG κ及IgG λ。
在另一實施例中,潛在地包含表現良好之獨立蛋白質域的前導序列可融合至由蛋白酶裂解位點分離之BPXTEN序列的N端。雖然可使用在所設計蛋白水解位點處不抑制裂解之任何前導肽序列,但在較佳實施例中,序列將包含穩定、表現良好之序列,使得整個組合物之表現及摺疊不受顯著不利影響,且較佳使表現、溶解性及/或摺疊效率得到顯著改良。已在文獻中描述廣泛多種適合之前導序列。適合序列之非限制性清單包括麥芽糖結合蛋白、纖維素結合域、麩胱甘肽S轉胺酶、6xHis標籤(SEQ ID NO: 263)、旗標標籤、血球凝集素標籤及綠色螢光蛋白。前導序列亦可藉由密碼子最佳化,尤其在ATG起始密碼子後之第二密碼子位置中,藉由文獻及上文充分描述之方法進一步改良。
已知用於在特定位點裂解蛋白質之各種活體外酶方法。此類方法包括使用腸激酶(DDDK(SEQ ID NO: 264))、因子Xa(IDGR(SEQ ID NO: 265))、凝血酶(LVPRGS(SEQ ID NO: 266))、PreScission™(LEVLFQGP(SEQ ID NO: 267))、TEV蛋白酶(EQLYFQG(SEQ ID NO: 268))、3C蛋白酶(ETLFQGP(SEQ ID NO:269))、分選酶A(LPETGSEQ ID NO:909)、顆粒酶B(D/X、N/X、M/N或S/X)、內含肽、SUMO、DAPase、(TAGZyme™)、氣單胞菌屬胺基肽酶、胺基肽酶M及羧基肽酶A及B。額外方法揭示於Arnau等人, Protein Expression and Purification 48: 1-13 (2006)。
在其他實施例中,編碼具有XTEN特徵之至少約20至約60個胺基酸的最佳化聚核苷酸序列可包括在XTEN序列之N端處以促進轉譯之起始以允許在不存在輔助域之情況下在蛋白質之N端處表現XTEN融合物。在前述之優勢中,序列不需要後續裂解,由此減少製造含XTEN組合物之步驟的數目。如實例中更詳細地描述,最佳化N端序列具有非結構化蛋白質之屬性,但可包括編碼胺基酸之核苷酸鹼基,該等胺基酸經選擇以促進轉譯起始及增強表現的能力。在前述一個實施例中,最佳化聚核苷酸編碼與AE912(SEQ ID NO: 217)具有至少約90%序列一致性之XTEN序列。在以上另一實施例中,最佳化聚核苷酸編碼與AM923(SEQ ID NO: 218)具有至少約90%序列一致性之XTEN序列。
在另一個實施例中,選擇前導序列構築體之蛋白酶位點以使得其由活體內蛋白酶識別。在此實施例中,蛋白質自表現系統純化,同時藉由避免與適當蛋白酶接觸而保留前導序列。接著將全長構築體注射至患者體內。注射後,構築體與對裂解位點具有特異性之蛋白酶接觸且由蛋白酶裂解。在未裂解蛋白質之活性實質上小於裂解形式之情況下,此方法具有允許更高初始劑量同時避免毒性之有益作用,因為活性形式在活體內緩慢產生。適用於本申請案之活體內蛋白酶之一些非限制性實例包括組織激肽釋放酶、血漿激肽釋放酶、胰蛋白酶、胃蛋白酶、胰凝乳蛋白酶、凝血酶及基質金屬蛋白酶,或
表 5之蛋白酶。
以此方式,編碼單體BPXTEN融合蛋白之嵌合DNA分子在構築體內產生。視情況,此嵌合DNA分子可轉移或選殖至為更適合表現載體之另一構築體中。此時,能夠表現嵌合DNA分子之宿主細胞可經嵌合DNA分子轉化。含有相關DNA區段之載體可藉由視細胞生產宿主之類型而定的熟知方法轉移至宿主細胞中。舉例而言,氯化鈣轉染通常用於原核細胞,而磷酸鈣處理、脂質體轉染或電穿孔可用於其他細胞宿主。用於轉型哺乳動物細胞之其他方法包括使用凝聚胺、原生質體融合、脂質體、電穿孔及顯微注射。一般而言,參見,Sambrook等人, 前述。
轉化可在利用或不利用載劑(諸如表現載體)之情況下發生。隨後,經轉化之宿主細胞在適合於表現編碼BPXTEN之嵌合DNA分子的條件下培養。
本發明亦提供用於表現本文所揭示之單體融合蛋白組合物的宿主細胞。適合之真核宿主細胞之實例包括(但不限於)哺乳動物細胞,諸如VERO細胞、諸如ATCC No. CCL2之HELA細胞、CHO細胞株、COS細胞、WI38細胞、BHK細胞、HepG2細胞、3T3細胞、A549細胞、PC12細胞、K562細胞、293細胞、Sf9細胞及CvI細胞。適合之非哺乳動物真核細胞之實例包括真核微生物,諸如絲狀真菌或酵母,為適合用於編碼載體之選殖或表現宿主。
釀酒酵母為常用的低級真核宿主微生物。其他包括粟酒裂殖酵母(
Schizosaccharomyces pombe)(Beach and Nurse, Nature, 290: 140 [1981];於1985年五月2日公開之EP 139,383);克魯維酵母(
Kluyveromyces)宿主(美國專利第4,943,529號;Fleer等人,Bio/Technology, 9:968-975 (1991)),諸如例如乳酸克魯維酵母(
K. lactis)(MW98-8C、CBS683、CBS4574;Louvencourt等人, J. Bacteriol., 737 [1983])、脆壁酵母(
K.fragilis)(ATCC 12,424)、保加利亞酵母(
K.bulgaricus)(ATCC 16,045)、魏氏酵母(
K.wickeramii)(ATCC 24,178)、沃爾第酵母(
K. waltii)(ATCC 56,500)、果蠅克魯維酵母(
K. drosophilarum)(ATCC 36,906;Van den Berg等人, Bio/Technology, 8:135 (1990))、耐熱克魯維酵母(
K. thermotolerans)及馬克斯克魯維酵母(
K. marxianus);亞羅酵母屬(
yarrowia)(EP 402,226);畢赤酵母(
Pichia pastoris)(EP 183,070;Sreekrishna等人, J. Basic Microbiol., 28:265-278 [1988]);念珠菌屬(
Candida);瑞氏木黴(
Trichoderma reesia)(EP 244,234);粗糙脈孢菌(
Neurospora crassa)(Case等人, Proc. Natl. Acad. Sci. USA, 76:5259-5263 [1979]);施氏酵母(
Schwanniomyces),諸如西方施氏酵母(
Schwanniomyces occidentalis)(於1990年十月31日公開之EP 394,538);及絲狀真菌,諸如紅黴菌屬(
Neurospora)、青黴菌屬(
Penicillium)、彎頸黴屬(
Tolypocladium)(於1991年一月10日公開之WO 91/00357)及曲黴菌屬(
Aspergillus)宿主,諸如構巢麴菌(
A. nidulans)(Ballance等人, Biochem. Biophys. Res. Commun., 112:284-289 [1983];Tilburn等人, Gene, 26:205-221 [1983];Yelton等人, Proc. Natl. Acad. Sci. USA, 81: 1470-1474 [1984])及黑麴菌(
A. niger)(Kelly及Hynes, EMBO J., 4:475-479 [1985])。甲基營養型酵母在本文中為適合的且包括(但不限於)能夠在選自由漢森酵母屬(
Hansenula)、念珠菌屬、克勒克酵母屬(
Kloeckera)、畢赤酵母屬、酵母菌屬、球擬酵母屬(
Torulopsis)及紅酵母屬(
Rhodotorula)組成之屬的甲醇上生長之酵母菌。作為此類別之酵母菌之示例的特定物種之清單可發現於C. Anthony, The Biochemistry of Methylotrophs, 269 (1982)中。
可用於本發明中之其他適合細胞包括(但不限於)原核宿主細胞菌株,諸如大腸桿菌(例如菌株DH5-α)、枯草桿菌、嗜沙門氏菌屬或假單胞菌屬、鏈黴菌及葡萄球菌屬菌株。適合原核生物之非限制性實例包括來自以下屬之彼等:遊動放線菌屬(
Actinoplanes);古生球菌屬(
Archaeoglobus);蛭弧菌屬(
Bdellovibrio);螺旋體屬(
Borrelia);綠屈撓菌屬(
Chloroflexus);腸球菌屬(
Enterococcus);埃希氏菌屬(
Escherichia);乳桿菌屬(
Lactobacillus);李斯特菌屬(
Listeria);大洋芽胞桿菌屬(
Oceanobacillus);副球菌屬(
Paracoccus);假單胞菌屬(
Pseudomonas);葡萄球菌屬(
Staphylococcus);鏈黴菌屬(
Streptococcus);鏈黴菌屬(
Streptomyces);熱原體屬(
Thermoplasma)及弧菌屬(
Vibrio)。特定菌株之非限制性實例包括:閃爍古生球菌(
Archaeoglobus fulgidus);食菌蛭弧菌(
Bdellovibrio bacteriovorus);伯氏疏螺旋體(
Borrelia burgdorferi);橙色綠屈撓菌(
Chloroflexus aurantiacus);糞腸球菌(
Enterococcus faecalis);屎腸球菌(
Enterococcus faecium);約氏乳桿菌(
Lactobacillus johnsonii);植物乳桿菌(
Lactobacillus plantarum);乳酸乳球菌(
Lactococcus lactis);無害李斯特氏菌(
Listeria innocua);產單核球李斯特氏菌(
Listeria monocytogenes);伊平屋海嶺海洋芽孢桿菌(
Oceanobacillus iheyensis);產玉米黃素副球菌(
Paracoccus zeaxanthinifaciens);甲輕戊酸假單胞菌(
Pseudomonas mevalonii);金黃色葡萄球菌(
Staphylococcus aureus);表皮葡萄球菌(
Staphylococcus epidermidis);溶血性葡萄球菌(
Staphylococcus haemolyticus);無乳鏈球菌(
Streptococcus agalactiae);灰色孢鏈黴菌(
Streptomyces griseolosporeus);變形鏈球菌(
Streptococcus mutans);肺炎鏈球菌(
Streptococcus pneumoniae);化膿性鏈球菌(
Streptococcus pyogenes);嗜酸熱原體菌(
Thermoplasma acidophilum);火山熱原體菌(
Thermoplasma volcanium);霍亂弧菌(
Vibrio cholerae);副溶血弧菌(
Vibrio parahaemolyticus)及創傷弧菌(
Vibrio vulnificus)。
含有相關聚核苷酸之宿主細胞可在適於活化啟動子、選擇轉化體或擴增基因之經改造之習知養分培養基(例如Ham氏營養物混合物)中培養。培養條件(諸如溫度、pH值及其類似條件)為先前用於經選擇用於表現之宿主細胞之培養條件,且對於一般熟習此項技術者而言將顯而易見。細胞通常藉由離心採集、藉由物理或化學手段破壞且所得粗製提取物經保留以供進一步純化。對於宿主細胞分泌之組合物而言,分離來自離心之上清液且保留用於進一步純化。蛋白質表現中所用之微生物細胞可藉由任何便利方法破壞,包括凍融循環、音波處理、機械破壞或使用細胞溶解劑,其皆為熟習此項技術者所熟知。涉及細胞溶解之實施例可能需要使用含有限制在嵌合DNA分子表現之後降解的蛋白酶抑制劑的緩衝劑。適合的蛋白酶抑制劑包括(但不限於)亮抑酶肽、胃酶抑素或抑肽酶。上清液接著可在連續增加濃度之飽和硫酸銨中沈澱。
可在樣品中直接量測基因表現,例如藉由用以定量mRNA之轉錄的習知南方墨點法、北方墨點法([Thomas, Proc. Natl. Acad. Sci. USA, 77:5201-5205 (1980))、斑點雜交(dot blotting)(DNA分析)或原位雜交,使用經適當標記地探針,基於本文所提供之序列。或者,可採用能識別特定雙螺旋體,包括DNA雙螺旋體、RNA雙螺旋體及DNA-RNA混合雙螺旋體或DNA-蛋白質雙螺旋體的抗體。抗體又可經標記且可進行分析,其中雙螺旋體結合至表面,以使得在表面上形成雙螺旋體時,可偵測到結合至雙螺旋體之抗體的存在。
或者,基因表現可藉由螢光方法,諸如細胞或組織切片之免疫組織化學染色及細胞培養物或體液之分析或可選擇標記之偵測來量測,以直接定量基因產物之表現。適用於免疫組織化學染色及/或樣品流體分析之抗體可為單株或多株的,且可在任何哺乳動物中製備。適宜地,可基於本文所提供之DNA序列或針對融合至BP且編碼特異性抗體抗原決定基之外源性序列,針對天然序列BP多肽或針對合成肽來製備抗體。可選標記之實例為熟習此項技術者所熟知且包括報導子,諸如增強型綠色螢光蛋白(EGFP)、β-半乳糖苷酶(β-gal)或氯黴素乙醯基轉移酶(CAT)。
表現之BPXTEN多肽產物可經由此項技術中已知之方法或藉由本文所揭示之方法純化。可使用諸如凝膠過濾、親和純化、鹽分餾、離子交換層析法、尺寸排阻層析法、羥基磷灰石吸附層析法、疏水性相互作用層析法及凝膠電泳之程序;每一者經調適以回收及純化由各別宿主細胞產生之融合蛋白。一些表現之BPXTEN在分離及純化期間可能需要再摺疊。純化方法描述於Robert K. Scopes, Protein Purification: Principles and Practice, Charles R. Castor (編), Springer-Verlag 1994,及Sambrook,等人, 前述。多步驟純化分離亦描述於Baron,等人, Crit. Rev. Biotechnol. 10:179-90 (1990)及Below,等人, J. Chromatogr. A. 679:67-83 (1994)。
醫藥組合物
細胞介素可在治療各種治療性或疾病類別中具有效用,包括(但不限於)癌症、類風濕性關節炎、多發性硬化症、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症、精神分裂症
、病毒感染(例如,慢性C型肝炎、AIDS)、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症。
然而,細胞介素之治療效用在一些情況下可能受到限制,因為一些細胞介素,諸如IL-2、IL-12、IL15、I型干擾素(α及β)及IFN-γ在全身性遞送時可能對宿主細胞有毒。延長循環細胞介素之半衰期可為藉由減緩細胞內吸收來降低細胞毒性的方式。
本發明中之BPXTEN提供藉由細胞介素連接至XTEN而延長細胞介素之半衰期的方法及組合物。在一個實施例中,醫藥組合物包含BPXTEN融合蛋白及至少一種醫藥學上可接受之載劑。本發明之BPXTEN多肽可根據已知製備醫藥學上適用之組合物的方法進行調配,其中多肽以與醫藥學上可接受之載劑媒劑,諸如水溶液或緩衝劑、醫藥學上可接受之懸浮液及乳液之摻合物形式組合。非水溶劑之實例包括丙基乙二醇、聚乙二醇及植物油。製備治療性調配物以用於儲存,其藉由將具有所需純度之活性成分與視情況選用之生理學上可接受之載劑、賦形劑或穩定劑混合來進行(如中Remington's Pharmaceutical Sciences 第16版, Osol, A.編(1980)所描述),呈凍乾調配物或水溶液形式。
醫藥組合物可經口、鼻內、非經腸或藉由吸入療法投與,且可呈錠劑、口含錠、顆粒劑、膠囊、丸劑、安瓿、栓劑或氣霧劑形式。其亦可呈含活性成分之水性或非水性稀釋劑、糖漿劑、顆粒劑或粉劑之懸浮液、溶液及乳液形式。另外,醫藥組合物亦可含有其他醫藥學活性化合物或複數種本發明化合物。醫藥組合物經調配用於經口、真皮內、皮下、靜脈內、動脈內、腹內、腹膜內、鞘內或肌肉內投與。醫藥組合物可呈液體形式。醫藥組合物可在用於單次注射之預填充注射器中。醫藥組合物可經調配為在待投與之前復原之凍乾粉末。
更特定言之,本發明醫藥組合物可藉由任何適合途徑投與用於療法,包括經口、經直腸、經鼻、局部(包括經皮、氣霧劑、經頰及舌下)、經陰道、非經腸(包括皮下、藉由注射泵之皮下、肌內、靜脈內及真皮內)、玻璃體內及經肺。亦應瞭解,較佳途徑隨接受者之病況及年齡以及所治療之疾病而變化。
在一個實施例中,醫藥組合物經皮下投與。在此實施例中,組合物可呈在投與之前復原之凍乾粉末形式供應。組合物亦可呈液體形式供應,其可直接向患者投與。在一個實施例中,在預填充注射器中以液體形式供應組合物,使得患者可容易地自行投與組合物。
適用於本發明之延長釋放調配物可為包含基質及包衣組合物之經口調配物。適合基質材料可包括蠟(例如,巴西棕櫚蠟(camauba)、蠟、石蠟、白地蠟(ceresine)、蟲膠蠟、脂肪酸及脂肪醇)、油、硬化油或脂肪(例如,硬化菜籽油、蓖麻油、牛油、棕櫚油及豆油)及聚合物(例如,羥丙基纖維素、聚乙烯吡咯啶酮、羥丙基甲基纖維素及聚乙二醇)。其他適合基質壓片材料為微晶纖維素、粉末纖維素、羥丙基纖維素、乙基纖維素與其他載劑及填充劑。錠劑亦可含有顆粒、包衣粉末或集結粒。錠劑亦可為多層的。當活性成分具有顯著不同的藥物動力學概況時,多層錠劑尤其較佳。視情況,成品錠劑可經包覆或未經包覆。
包衣組合物可包含不可溶基質聚合物及/或水溶性材料。水溶性材料可為聚合物,諸如聚乙二醇、羥丙基纖維素、羥丙基甲基纖維素、聚乙烯吡咯啶酮、聚乙烯醇或單體材料,諸如糖(例如乳糖、蔗糖、果糖、甘露醇及其類似物)、鹽(例如氯化鈉、氯化鉀及其類似物)、有機酸(例如反丁烯二酸、丁二酸、乳酸及酒石酸)及其混合物。視情況,腸溶聚合物可併入至包衣組合物中。適合之腸溶聚合物包括羥丙基甲基纖維素、乙酸酯丁二酸酯、羥丙基甲基纖維素、聚乙酸乙烯酯鄰苯二甲酸酯、鄰苯二甲酸乙酸纖維素、偏苯三甲酸乙酸纖維素、蟲膠、玉米蛋白及含有羧基之聚甲基丙烯酸酯。可藉由添加適合之塑化劑來塑化包衣組合物,該塑化劑諸如鄰苯二甲酸二乙酯、檸檬酸酯、聚乙二醇、丙三醇、乙醯化甘油酯、乙醯化檸檬酸酯、癸二酸二丁酯以及蓖麻油。包衣組合物亦可包括填充劑,該填充劑可為不溶性材料,諸如二氧化矽、二氧化鈦、滑石、高嶺土、氧化鋁、澱粉、粉末纖維素、MCC或波拉克林鉀。可將包衣組合物作為溶液或乳膠在有機溶劑或水溶劑或其混合物中施加。可使用溶劑,諸如水、低級醇、低級氯化烴、酮或其混合物。
本發明之組合物可使用多種賦形劑調配。適合之賦形劑包括微晶纖維素(例如Avicel PH102、Avicel PH101)、聚甲基丙烯酸酯、聚(丙烯酸乙酯、甲基丙烯酸甲酯、甲基丙烯酸三甲基銨乙酯氯化物)(諸如Eudragit RS-30D)、羥丙基甲基纖維素(甲基纖維素K100M、Premium CR甲基纖維素K100M、甲基纖維素E5、Opadry®)、硬脂酸鎂、滑石、檸檬酸三乙酯、水性乙基纖維素分散液(Surelease®)及硫酸魚精蛋白。緩釋劑亦可包含載劑,該載劑可包含例如溶劑、分散介質、包衣、抗細菌劑及抗真菌劑、等張劑及吸收延遲劑。醫藥學上可接受之鹽亦可用於此等緩釋劑,例如無機酸鹽,諸如鹽酸鹽、氫溴酸鹽、磷酸鹽或硫酸鹽,以及有機酸之鹽,諸如乙酸鹽、丙酸鹽、丙二酸鹽或苯甲酸鹽。組合物亦可含有液體,諸如水、鹽水、丙三醇及乙醇,以及物質,諸如潤濕劑、乳化劑或pH緩衝劑。脂質體亦可作為載劑使用。
在另一實施例中,本發明之組合物囊封於脂質體中,其在長時間內以受控方式遞送有益活性劑方面具有效用。脂質體係封閉的雙層膜,含有包覆之水體積。脂質體亦可為具有單個膜雙層之單層囊泡或具有多個膜雙層之多層囊泡,各膜雙層藉由水層與下一個膜雙層分離。所得膜雙層之結構使得脂質之疏水性(非極性)尾部朝向雙層之中心定向,而親水性(極性)頭部朝向水相定向。在一個實施例中,脂質體可包覆有可撓性水溶性聚合物,避免由單核吞噬細胞系統之器官(主要為肝臟及脾臟)吸收。用於包圍脂質體之適合親水性聚合物包括(但不限於)PEG、聚乙烯吡咯啶酮、聚乙烯甲基醚、聚甲基
唑啉、聚乙基
唑啉、聚羥丙基
唑啉、聚羥基丙基甲基丙烯醯胺、聚甲基丙烯醯胺、聚二甲基丙烯醯胺、聚羥基丙基甲基丙烯酸酯、聚羥乙基丙烯酸酯、羥基甲基纖維素、羥基乙基纖維素、聚乙二醇、聚天冬醯胺及親水性肽序列,如美國專利第6,316,024號;第6,126,966號;第6,056,973號;第6,043,094號中所描述,該等專利之內容以全文引用之方式併入。
脂質體可由此項技術中已知之任何脂質或脂質組合構成。舉例而言,囊泡形成脂質可為天然存在之脂質或合成脂質,包括磷脂,諸如磷脂醯膽鹼、磷脂醯乙醇胺、磷脂酸、磷脂醯絲胺酸、磷脂醯甘油、磷脂醯肌醇及鞘磷脂,如美國專利第6,056,973號及第5,874,104號中所揭示。囊泡形成脂質亦可為醣脂、腦苷脂或陽離子脂質,諸如1,2-二油醯氧基-3-(三甲基胺基)丙烷(DOTAP);N-[1-(2,3,-二(十四烷基)氧基)丙基]-N,N-二甲基-N-羥乙基溴化銨(DMRIE);N-[1 [(2,3,-二油醯氧基)丙基]-N,N-二甲基-N-羥乙基溴化銨(DORIE);N-[1-(2,3-二油醯氧基)丙基]-N,N,N-三甲基氯化銨(DOTMA);3 [N-(N',N'-二甲基胺基乙烷)胺甲醯基]膽固醇(DC-Chol);或二甲基二(十八烷基)銨(DDAB),亦如美國專利第6,056,973號中所揭示。膽固醇亦可以適當範圍存在,以賦予囊泡穩定性,如美國專利第5,916,588號及第5,874,104號中所揭示。
其他脂質體技術描述於美國專利第6,759,057號;第6,406,713號;第6,352,716號;第6,316,024號;第6,294,191號;第6,126,966號;第6,056,973號;第6,043,094號;第5,965,156號;第5,916,588號;第5,874,104號;第5,215,680號;及第4,684,479號中,該等專利之內容以全文引用之方式併入。此等描述經脂質體及經脂質包覆之微泡,及其製造方法。因此,熟習此項技術者考慮到本發明之揭示內容及此等其他專利之揭示內容均可產生用於本發明多肽之延長釋放的脂質體。
對於液體調配物,所需特性為調配物的形式供應可以通過25、28、30、31、32號標準規格針以用於靜脈內、肌肉內、關節內或皮下投與。
經由經皮調配物之投與可使用此項技術中亦已知之方法進行,包括一般描述於例如美國專利第5,186,938號及6,183,770號、第4,861,800號、第6,743,211號、第6,945,952號、第4,284,444號及WO 89/09051之彼等,以全文引用的方式併入本文中。經皮貼片係具有吸收問題之多肽的尤其適用的實施例。可製造貼片以控制皮膚可滲透活性成分在12小時、24小時、3天及7天時間段內之釋放。在一個實例中,將每天2倍過量之本發明之多肽置放於非揮發性流體中。本發明之組合物係以黏稠、非揮發性液體形式提供。特定調配物經由皮膚之滲透性可藉由此項技術中之標準方法量測(例如Franz等人, J. Invest. Derm. 64:194-195 (1975))。適合之貼片之實例為被動轉移皮膚貼片、離子導入皮膚貼片或具有微針之貼片(諸如Nicoderm)。
在其他實施例中,組合物可經由鼻內、頰內或舌下途徑遞送至腦部以使得活性劑能夠經由嗅覺通道轉移至CNS中且減少全身性投與。常用於此投與途徑之裝置包括在美國專利 第6,715,485號中。經由此途徑遞送之組合物可實現增加CNS給藥或降低整體全身負擔,從而降低與某些藥物相關之全身毒性風險。可使用此項技術中已知之方法進行用於在皮下可植入裝置中遞送之醫藥組合物的製備,諸如於美國專利第3,992,518號;第5,660,848號;及第5,756,115號中所描述之彼等方法。
滲透泵可用作呈錠劑、丸劑、膠囊或可植入裝置形式之緩釋劑。滲透泵為此項技術中熟知且一般熟習此項技術者可自提供用於延長釋放藥物遞送之滲透泵經驗豐富的公司容易獲得。實例為ALZA的DUROS™;ALZA的OROS™;Osmotica Pharmaceutical的Osmodex™系統;ShireLaboratories的EnSoTrol™系統;及;Alzet™。描述滲透泵技術之專利為美國專利第6,890,918號;第6,838,093號;第6,814,979號;第6,713,086號;第6,534,090號;第6,514,532號;第6,361,796號;第6,352,721號;第6,294,201號;第6,284,276號;第6,110,498號;第5,573,776號;第4,200,0984號;及第4,088,864號,該等專利之內容以全文引用之方式併入。熟習此項技術者考慮到本發明之揭示內容及此等其他專利之揭示內容均可產生用於本發明多肽之延長釋放的滲透泵。
注射泵亦可用作緩釋試劑。此類裝置描述於美國專利第4,976,696號;第4,933,185號;第5,017,378號;第6,309,370號;第6,254,573號;第4,435,173號;第4,398,908號;第6,572,585號;第5,298,022號;第5,176,502號;第5,492,534號;第5,318,540號;及第4,988,337號中,該等專利之內容以全文引用之方式併入。熟習此項技術者考慮到本發明之揭示內容及此等其他專利之揭示內容均可產生用於本發明組合物之延長釋放的注射泵。
醫藥套組
在另一態樣中,本發明提供一種有助於使用BPXTEN多肽之套組。在一個實施例中,套組至少在第一容器中包含:(a)一定量之BPXTEN融合蛋白組合物,其足以在向有需要之個體投與時治療疾病、病況或病症;及(b)一定量之醫藥學上可接受之載劑;一起組成可供注射或用無菌水、緩衝劑或右旋糖重組的調配物;連同標識BPXTEN藥物、儲存及處理條件的標籤,以及該藥物的批准適應症表、用於預防及/或治療批准適應症的BPXTEN藥物重組及/或投與說明、適當劑量及安全資訊,以及識別藥物批次及有效期的資訊。在前述另一實施例中,套組可包含可攜載適用於BPXTEN組合物之稀釋劑的第二容器,其將向使用者提供待遞送至個體之適當濃度之BPXTEN。
實例
實例 1 : XTEN 之構築
XTEN及各種組分可如WO 2010/091122中所描述製造及組裝,其以全文引用之方式併入本文中,且尤其參考其關於XTEN序列及其製造及組裝之教示內容。
實例 2 :產生及評估 BPXTEN 之方法;作為實例之 XTEN- 細胞介素
產生及評估BPXTEN組合物之一般概要呈現於圖
6中,且形成本實例之一般描述之基礎。使用所揭示之方法及一般熟習此項技術者已知之方法連同提供於說明性實例中之指南,熟習此項技術者可產生及評估包含此項技術中已知之XTEN、BP及BP變異體的BPXTEN融合蛋白的範圍。因此,實例應理解為僅為說明性的,且無論如何不以任何方式限制方法;許多變化形式對於一般熟習此項技術者而言將為顯而易見的。在此預示性實例中,將產生與AE家族模體之XTEN連接之IL10的BPXTEN。
用於產生編碼XTEN之聚核苷酸的一般概要呈現於圖4及5中。
圖 5為本發明之一個實施例中XTEN聚核苷酸構築體之組裝中代表性步驟的示意性流程圖。將個別寡核苷酸
501黏接成序列模體
502,諸如12個胺基酸模體(「12聚體」),其隨後與含有BbsI及KpnI限制性位點之寡核苷酸
503接合。模體庫可限於特定序列XTEN家族;例如
表 1之AD、AE、AF、AG、AM或AQ序列。在此情況下,AE家族之模體(SEQ ID NO: 186-189)將用作模體庫,將該模體庫黏接成12聚體以產生「建構組元」長度;例如編碼36個胺基酸之區段。編碼XTEN序列之基因可藉由接合及多聚化「建構組元」進行組裝,直至達成XTEN基因
504之所需長度。如圖
5中所示,在此情況下XTEN長度為48個胺基酸殘基,但可藉由此方法獲得較長長度。例如,多聚化可藉由接合、重疊延伸、PCR組裝或此項技術中已知之類似選殖技術進行。可將XTEN基因選殖至填充載體中。在
圖 5中所示之實施例中,載體可編碼旗標序列
506,隨後為由BsaI、BbsI及KpnI位點側接之填充序列
507及BP基因(例如腸促胰島素類似物-4)
508,產生編碼BPXTEN
500之基因,在該種狀況下其編碼N端至C端XTEN-IL10組態之融合蛋白。
編碼IL10(或另一候選物BP)之DNA序列可方便地藉由此項技術中已知之標準程序自適當細胞來源製備之cDNA庫,自基因體庫獲得,或可使用獲自公開可用之資料庫、專利或文獻參考之DNA序列以合成方式(例如自動化核酸合成)產生。接著可以將編碼蛋白質之IL10部分的基因或聚核苷酸選殖至構築體中,諸如本文所描述之構築體中,該構築體可為質體或其他載體,在適當轉錄及轉譯序列控制下用於在生物系統中進行高水準蛋白質表現。編碼XTEN部分之第二基因或聚核苷酸(在
圖 5所示為具有48個胺基酸殘基之AE的情況下)可藉由經由接合或多聚化步驟將其選殖至與編碼IL10之基因相鄰且同框之構築體中而基因融合於編碼IL10基因之N端的核苷酸。以此方式,編碼(或與其互補)XTEN-IL10 BPXTEN融合蛋白之嵌合DNA分子將在構築體內產生。構築體可以不同組態設計以將融合搭配物之各種排列編碼為單體多肽。舉例而言,基因可經創建以按順序(N端至C端)編碼融合蛋白:IL10-XTEN;XTEN-IL10;IL10-XTEN-IL10;XTEN-IL10-XTEN;以及前述多聚體。視情況,此嵌合DNA分子可轉移或選殖至為更適合表現載體之另一構築體中。此時,能夠表現嵌合DNA分子之宿主細胞將經嵌合DNA分子轉化。含有相關DNA區段之載體可藉由熟知方法轉移至適當宿主細胞中,視細胞宿主之類型而定,如上文所描述。
含有XTEN-IL10表現載體之宿主細胞將在經修飾以適於活化啟動子之習知營養物培養基中培養。培養條件(諸如溫度、pH值及其類似條件)為先前用於經選擇用於表現之宿主細胞之培養條件,且對於一般熟習此項技術者而言將顯而易見。在表現融合蛋白之後,細胞將藉由離心收集,藉由物理或化學手段破壞,且所得粗製提取物經保留以供融合蛋白純化,如下文所描述。對於宿主細胞分泌之BPXTEN組合物而言,將分離來自離心之上清液且保留用於進一步純化。
基因表現可在樣品中直接量測,例如藉由用以定量mRNA之轉錄的習知南方墨點法、北方墨點法(Thomas, Proc. Natl. Acad. Sci. USA, 77:5201-5205 (1980))、斑點雜交(DNA分析)或原位雜交,使用經適當標記地探針,基於本文所提供之序列。或者,基因表現可藉由螢光方法,諸如細胞之免疫組織化學染色來量測,以直接定量基因產物之表現。適用於免疫組織化學染色及/或樣品流體分析之抗體可以為單株或多株的,且可在任何哺乳動物中製備。適宜地,可基於本文所提供之序列或針對融合至IL10且編碼特異性抗體抗原決定基之外源性序列,針對IL10序列多肽來製備抗體。可選標記之實例為熟習此項技術者所熟知且包括報導子,諸如增強型綠色螢光蛋白(EGFP)、β-半乳糖苷酶(β-gal)或氯黴素乙醯基轉移酶(CAT)。
XTEN-IL10多肽產物將經由此項技術中已知之方法純化。諸如凝膠過濾、親和純化、鹽分餾、離子交換層析法、尺寸排阻層析法、羥基磷灰石吸附層析法、疏水性相互作用層析法及凝膠電泳之程序皆為可用於純化之技術。純化之特定方法描述於Robert K. Scopes, Protein Purification: Principles and Practice, Charles R. Castor編, Springer-Verlag 1994,及Sambrook,等人, 前述。多步驟純化分離亦描述於Baron,等人, Crit. Rev. Biotechnol. 10:179-90 (1990)及Below,等人, J. Chromatogr. A. 679:67-83 (1994)。
如
圖 6中所示,接著將經分離之XTEN-IL10融合蛋白針對其化學及活性特性進行表徵。使用此項技術中已知之標準方法,將經分離之融合蛋白例如對於序列、純度、表觀分子量、溶解度及穩定性進行表徵。隨後將評估符合預期標準之融合蛋白的活性,其可使用本文所揭示之一或多種分析活體外或活體內量測。
另外,將XTEN-IL10融合蛋白投與一或多種動物物種以測定標準藥物動力學參數,如實例25中所描述。
藉由產生、表現及回收XTEN-IL10構築體之迭代過程,隨後使用本文所揭示之方法或此項技術中已知之其他方法進行表徵,可產生包含IL10及XTEN之BPXTEN組合物,且由一般熟習此項技術者評估以證實預期特性(諸如增強之溶解度、增強之穩定性、改良之藥物動力學及降低之免疫原性)產生與相應未融合IL10相比整體增強之治療活性。對於不具有所需特性之彼等融合蛋白,不同序列可藉由此等方法構築、表現、分離及評估以便獲得具有此類特性之組合物。
實例 3 : XTEN 融合蛋白之分析尺寸排阻層析法
對含有各種治療蛋白及增加長度之非結構化重組蛋白的融合蛋白進行尺寸排阻層析法分析。例示性分析使用TSKGel-G4000 SWXL(7.8 mm×30 cm)管柱,其中濃度為1 mg/ml之40 μg經純化之升糖素融合蛋白在20 mM磷酸鹽pH 6.8、114 mM NaCl中以0.6 ml/min之流動速率分離。使用OD214nm及OD280nm監測層析圖概況。所有分析之管柱校準使用來自BioRad之尺寸排阻校準標準進行。認為包含IL10及XTEN之融合蛋白可降低腎清除率,從而促成增加終末半衰期且相對於相應未融合生物活性蛋白改良了治療或生物效應。
實例 4 : C 端 XTEN 之釋放速率最佳化
可產生融合蛋白之變異體,其中C端XTEN之釋放速率改變。由於XTEN釋放蛋白酶之XTEN釋放速率視XTEN釋放位點之序列而定,藉由改變XTEN釋放位點中之胺基酸序列,吾人可控制XTEN釋放速率。多種蛋白酶之序列特異性為此項技術中所熟知,且記錄於若干資料庫中。在此情況下,蛋白酶之胺基酸特異性將使用受質之組合庫[Harris, J. L.等人, (2000)
Proc Natl Acad Sci U S A,
97: 7754]或藉由裂解受質混合物,如[Schellenberger, V.等人, (1993)
Biochemistry,
32: 4344]中所說明來進行映射。替代方案為藉由噬菌體展示來識別所需蛋白酶裂解序列[Matthews, D.等人, (1993)
Science,
260: 1113]。構築體將用變異體序列製成且使用用於偵測XTEN多肽之標準分析來分析XTEN釋放。
實例 5 :藉由預測演算法分析二級結構之序列
胺基酸序列可經由某些電腦程式或演算法來評估二級結構,諸如熟知的Chou-Fasman演算法(Chou, P. Y.,等人 (1974)
Biochemistry,
13: 222-45)及Garnier-Osguthorpe-Robson或(「GOR」)方法(Garnier J, Gibrat JF, Robson B. (1996). GOR method for predicting protein secondary structure from amino acid sequence. Methods Enzymol 266:540-553)。對於給定序列,演算法可預測存在一些二級結構或根本不存在,表示為形成例如α-螺旋或β-摺疊之序列之殘基的總數及/或百分比或預測導致無規捲曲形成之序列之殘基的百分比。
已使用兩個用於Chou-Fasman及GOR方法之演算法工具評估來自XTEN「家族」之若干代表性序列以評估此等序列中二級結構之程度。Chou-Fasman工具由William R.Pearson及弗吉尼亞大學的「生物支持(Biosupport)」網際網路站點提供,網址為全球資訊網.fasta.bioch.virginia.edu/fasta_www2/fasta_www.cgi?rm=misc1,因其存在於2009年6月19日。GOR工具由Pole Informatique Lyonnais在網路蛋白質序列分析網際網路站點提供,網址為全球資訊網.npsa-pbil.ibcp.fr/cgi-bin/secpred_gor4.pl,因其存在於2008年6月19日。
作為分析中之第一步驟,單一XTEN序列藉由兩種演算法進行分析。AE864組合物為具有864個胺基酸殘基之XTEN,該等胺基酸殘基由四個12個胺基酸序列模體之多個複本產生,該等胺基酸序列模體由胺基酸G、S、T、E、P及A組成。序列模體之特徵在於在模體內及在整個序列內存在限制的重複量,因為任何兩個連續胺基酸之序列任一個12個胺基酸模體中的重複不超過兩次,且全長XTEN沒有三個連續胺基酸為相同的。藉由Chou-Fasman及GOR演算法分析AF 864序列自N端之連續較長部分(後者需要最小長度為17個胺基酸)。藉由將FASTA格式序列輸入預測工具且進行分析來分析序列。分析之結果呈現於
表 10中。
結果指示,藉由周-Fasman計算,AE家族之四個模體((
表 1)不具有α-螺旋或β摺疊。類似地發現具有至多288個殘基之序列不具有α-螺旋或β摺疊。預測432個殘基序列具有少量二級結構,其中僅2個胺基酸促成α-螺旋,總百分比為0.5%。全長AF864多肽具有促成α-螺旋之相同的兩個胺基酸,總百分比為0.2%。針對無規捲曲形成之計算揭露,隨著長度增加,無規捲曲形成之百分比亦增加。序列之前24個胺基酸具有91%無規捲曲形成,其隨著長度增加,全長序列之無規捲曲形成值增加至多達99.77%。
亦分析來自其他模體家族之500個胺基酸或更長的許多XTEN序列,且顯示大部分具有大於95%無規捲曲形成。例外為具有三個連續絲胺酸殘基之一或多個實例之彼等序列,其導致預測至β摺疊形成。然而,即使此等序列仍具有約99%無規捲曲形成。
相比之下,受限於A、S及P胺基酸之84個殘基的多肽序列由Chou-Fasman演算法評估,該演算法預測了高度預測的α-螺旋。該序列具有多個重複「AA」及「AAA」序列,其α-螺旋結構之總體預測之百分比為69%。GOR演算法預測78.57%隨機捲曲形成;遠小於本發明實例分析之由胺基酸G、S、T、E、P組成的任何由12個胺基酸序列模體組成的序列。
結論:該分析支持以下結論:1)由對連續胺基酸具有有限重複性之G、S、T、E、P及A的多個序列模體產生的XTEN經預測為具有極低量之α-螺旋及β-摺疊;2)增加XTEN之長度不會明顯地增加α-螺旋或β-摺疊形成之機率;及3)藉由添加由胺基酸G、S、T、E、P及A組成之非重複12聚體逐漸增加XTEN序列之長度,使得隨機捲曲形成之百分比增加。相比之下,由受限於A、S及P之胺基酸產生的具有高度內部重複性之多肽經預測為具有高百分比之α-螺旋以及隨機捲曲形成,如藉由-Fasman算法所測定。基於藉由此等方法評估之許多序列,一般由具有受限重複性(定義為任何一個模體中不超過兩個相同連續胺基酸)且長度大於約400個胺基酸殘基之G、S、T、E、P及A之序列模體產生的XTEN預期具有極有限的二級結構。除含有三個連續絲胺酸之模體之外,咸信來自
表 1之序列模體的任何次序或組合可用於產生長度大於約400個殘基之XTEN多肽,該多肽將產生實質上不含二級結構之XTEN序列。預期此類序列具有本文所揭示之本發明之BPXTEN實施例中所描述的特徵。
表10:多肽序列之CHOU-FASMAN及GOR預測計算
*H:α-螺旋 E:β-摺疊
實例 6 :多肽序列重複性之分析
序列名稱 | SEQ ID NO: | 序列 | 殘基數目 | Chou-Fasman 計算 | GOR 計算 |
289 | GSTSESPSGTAP | 12 | 殘基總數*:H:0 E:0 百分比:H:0.0 E:0.0 | 未確定 | |
290 | GTSTPESGSASP | 12 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 未確定 | |
291 | GTSPSGESSTAP | 12 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 未確定 | |
292 | GSTSSTAESPGP | 12 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 未確定 | |
293 | GSPAGSPTSTEEGTSESATPESGP | 24 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 91.67 % | |
294 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP | 36 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 94.44% | |
295 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEE | 48 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 93.75% | |
296 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAP | 60 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 96.67% | |
297 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSE TPGSEPATSGSETP | 108 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 97.22% | |
298 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAP | 216 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 99.07% | |
299 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAP | 432 | 殘基總數:H:2 E:3 百分比:H:0.5 E :0.7 | 99.54% | |
AE864 | 300 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP | 864 | 殘基總數:H:2 E:3 百分比:H:0.2 E:0.3 | 99.77% |
AD 576 | 301 | GSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSGGEPSESGSSGSGGEPSESGSSGSGGEPSESGSSGSSESGSSEGGPGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSEGSSGPGESSGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSEGSSGPGESS | 576 | 殘基總數:H:7 E: 0百分比:H:1.2 E:0.0 | 99.65% |
AE576 | 302 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP | 576 | 殘基總數:H:2 E:0 百分比:H:0.4 E:0.0 | 99.65% |
AF540 | 303 | GSTSSTAESPGPGSTSSTAESPGPGSTSESPSGTAPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAP | 540 | 殘基總數:H:2 E: 0百分比:H:0.4 E:0.0 | 99.65 |
AF504 | 304 | GASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSP | 504 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 94.44% |
AE864 | 305 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP | 864 | 殘基總數:H:2 E:3 百分比:H:0.2 E:0.4 | 99.77% |
AF864 | 306 | GSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGPXXXGASASGAPSTXXXXSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSP | 875 | 殘基總數:H:2 E: 0百分比:H:0.2 E:0.0 | 95.20% |
AG864 | 307 | GGSPGASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSP | 868 | 殘基總數:H:0 E:0 百分比:H:0.0 E:0.0 | 94.70% |
AM875 | 308 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP | 875 | 殘基總數:H:7 E:3 百分比:H:0.8 E:0.3 | 98.63% |
AM1296 | 309 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGPEPTGPAPSGGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASASGAPSTGGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGASPGTSSTGSPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGSSTPSGATGSPGASPGTSSTGSPGSSTPSGATGSPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAP | 1318 | 殘基總數:H:7 E:0 百分比:H:0.7 E:0.0 | 99.17% |
AM923 | 310 | MAEPAGSPTSTEEGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP | 924 | 殘基總數:H:4 E: 3百分比:H:0.4 E:0.3 | 98.70% |
AE912 | 311 | MAEPAGSPTSTEEGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP | 913 | 殘基總數:H:8 E: 3 百分比:H:0.9 E:0.3 | 99.45% |
BC 864 | 312 | GTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSEPATSGTEPSGTSEPSTSEPGAGSGASEPTSTEPGTSEPSTSEPGAGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSGASEPTSTEPGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGSEPATSGTEPSGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGTSEPSTSEPGAGSGASEPTSTEPGTSTEPSEPGSAGTSTEPSEPGSAGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGSEPATSGTEPSGTSEPSTSEPGAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSAGSEPATSGTEPSGSGASEPTSTEPGTSTEPSEPGSA | 殘基總數:H:0 E: 0 百分比:H:0 E:0 | 99.77% | |
313 | ASPAAPAPASPAAPAPSAPAAAPASPAPAAPSAPAPAAPSAASPAAPSAPPAAASPAAPSAPPAASAAAPAAASAAASAPSAAA | 84 | 殘基總數:H:58 E:0 百分比:H:69.0 E:0.0 | 78.57% |
多肽胺基酸序列可藉由量化整個多肽內所出現之較短子序列之次數而評估重複性。舉例而言,200個胺基酸殘基之多肽具有192個重疊9-胺基酸子序列(或9聚體「框架」),但獨特9聚體序列之數目將視序列內之重複量而定。在本發明分析中,藉由對聚合物部分之前200個胺基酸中各3-胺基酸框架之所有唯一3聚體子序列之出現除以200個胺基酸序列內唯一3聚體子序列之絕對數進行求和來評估不同序列之重複量。所得子序列評分為多肽內之重複量程度之反映。
表 11中所示之結果指示,由2或3種胺基酸類型組成之非結構化多肽具有高子序列評分,而由內部重複性程度較低的六種胺基酸G、S、T、E、P及A之12個胺基酸模體組成的彼等非結構化多肽具有小於10,且在一些情況下,小於5的子序列評分。舉例而言,L288序列具有兩種胺基酸類型且具有短的高度重複序列,產生50.0之子序列評分。多肽J288具有三種胺基酸類型,但亦具有短重複序列,產生33.3之子序列評分。Y576亦具有三個胺基酸類型,但不由內部重複序列構成,反映在前200個胺基酸的子序列評分為15.7。W576由四種類型之胺基酸組成,但具有較高程度之內部重複量,例如「GGSG」(SEQ ID NO: 270),產生23.4之子序列評分。AD576由四種類型之12個胺基酸模體組成,該等模體各自由四種類型之胺基酸組成。因為個別模體之內部重複性程度較低,所以前200個胺基酸內之總子序列評分為13.6。相比之下,由四個模體組成之XTEN含有六種類型之胺基酸,每種胺基酸各自具有較低程度之內部重複性,具有較低子序列評分;例如AE864(6.1)、AF864(7.5)及AM875(4.5)。
結論:結果指示,12個胺基酸子序列模體(各自由四種至六種基本上非重複之胺基酸類型組成)組合成較長XTEN多肽,使得整體序列非重複。儘管每個子序列模體可能在整個序列中被多次使用,但依舊出現此情況。相比之下,由較小數目之胺基酸類型產生之聚合物產生較高子序列評分,但可定製實際序列以降低產生較低子序列評分的重複程度。
表11:多肽序列之子序列評分計算
實例 7 : TEPITOPE 評分計算
序列名稱 | SEQ ID NO: | 胺基酸序列 | 評分 |
J288 | 314 | GSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEGGSGGEG | 33.3 |
K288 | 315 | GEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEGGEGEGGGEG | 46.9 |
L288 | 316 | SSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSESSSESSESSSSES | 50.0 |
Y288 | 317 | GEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGGSEGSEGEGGSEGSEGEGSGEGSEGEGGSEGSEGEGSGEGSEGEGSEGGSEGEGGSEGSEGEGSGEGSEGEGGEGGSEGEGSEGSGEGEGSGEGSEGEGSEGSGEGEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGSEGSGEGEGGEGSGEGEGSGEGSEGEGGGEGSEGEGSGEGGEGEGSEGGSEGEGGSEGGEGEGSEGSGEGEGSEGGSEGEGSEGGSEGEGSEGSGEGEGSEGSGE | 26.8 |
Q576 | 318 | GGKPGEGGKPEGGGGKPGGKPEGEGEGKPGGKPEGGGKPGGGEGGKPEGGKPEGEGKPGGGEGKPGGKPEGGGGKPEGEGKPGGGGGKPGGKPEGEGKPGGGEGGKPEGKPGEGGEGKPGGKPEGGGEGKPGGGKPGEGGKPGEGKPGGGEGGKPEGGKPEGEGKPGGGEGKPGGKPGEGGKPEGGGEGKPGGKPGEGGEGKPGGGKPEGEGKPGGGKPGGGEGGKPEGEGKPGGKPEGGGEGKPGGKPEGGGKPEGGGEGKPGGGKPGEGGKPGEGEGKPGGKPEGEGKPGGEGGGKPEGKPGGGEGGKPEGGKPGEGGKPEGGKPGEGGEGKPGGGKPGEGGKPEGGGKPEGEGKPGGGGKPGEGGKPEGGKPEGGGEGKPGGGKPEGEGKPGGGEGKPGGKPEGGGGKPGEGGKPEGGKPGGEGGGKPEGEGKPGGKPGEGGGGKPGGKPEGEGKPGEGGEGKPGGKPEGGGEGKPGGKPEGGGEGKPGGGKPGEGGKPEGGGKPGEGGKPGEGGKPEGEGKPGGGEGKPGGKPGEGGKPEGGGEGKPGGKPGGEGGGKPEGGKPGEGGKPEG | 18.5 |
U576 | 319 | GEGKPGGKPGSGGGKPGEGGKPGSGEGKPGGKPGSGGSGKPGGKPGEGGKPEGGSGGKPGGGGKPGGKPGGEGSGKPGGKPEGGGKPEGGSGGKPGGKPEGGSGGKPGGKPGSGEGGKPGGGKPGGEGKPGSGKPGGEGSGKPGGKPEGGSGGKPGGKPEGGSGGKPGGSGKPGGKPGEGGKPEGGSGGKPGGSGKPGGKPEGGGSGKPGGKPGEGGKPGSGEGGKPGGGKPGGEGKPGSGKPGGEGSGKPGGKPGSGGEGKPGGKPEGGSGGKPGGGKPGGEGKPGSGGKPGEGGKPGSGGGKPGGKPGGEGEGKPGGKPGEGGKPGGEGSGKPGGGGKPGGKPGGEGGKPEGSGKPGGGSGKPGGKPEGGGGKPEGSGKPGGGGKPEGSGKPGGGKPEGGSGGKPGGSGKPGGKPGEGGGKPEGSGKPGGGSGKPGGKPEGGGKPEGGSGGKPGGKPEGGSGGKPGGKPGGEGSGKPGGKPGSGEGGKPGGKPGEGSGGKPGGKPEGGSGGKPGGSGKPGGKPEGGGSGKPGGKPGEGGKPGGEGSGKPGGSGKPG | 18.1 |
W576 | 320 |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| 23.4 |
Y576 | 321 | GEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGSEGSGEGEGGEGSGEGEGSGEGSEGEGGGEGSEGEGSGEGGEGEGSEGGSEGEGGSEGGEGEGSEGSGEGEGSEGGSEGEGSEGGSEGEGSEGSGEGEGSEGSGEGEGSEGSGEGEGSEGSGEGEGSEGGSEGEGGSEGSEGEGSGEGSEGEGGSEGSEGEGGGEGSEGEGSGEGSEGEGGSEGSEGEGGSEGSEGEGGEGSGEGEGSEGSGEGEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGGSEGSEGEGGSEGSEGEGGEGSGEGEGSEGSGEGEGSGEGSEGEGSEGSGEGEGSEGSGEGEGGSEGSEGEGSEGSGEGEGGEGSGEGEGSGEGSEGEGGGEGSEGEGSEGSGEGEGSEGSGEGEGSEGGSEGEGGSEGSEGEGSEGGSEGEGSEGGSEGEGSEGSGEGEGSEGSGEGEGSGEGSEGEGGSEGGEGEGSEGGSEGEGSEGGSEGEGGEGSGEGEGGGEGSEGEGSEGSGEGEGSGEGSE | 15.7 |
AD576 | 322 | GSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSSESGSSEGGPGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGSEGSSGPGESSGESPGGSSGSESGSGGEPSESGSSGSGGEPSESGSSGSGGEPSESGSSGSSESGSSEGGPGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSEGSSGPGESSGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGESPGGSSGSESGESPGGSSGSESGSSESGSSEGGPGSGGEPSESGSSGSSESGSSEGGPGSGGEPSESGSSGSGGEPSESGSSGESPGGSSGSESGSEGSSGPGESSGSSESGSSEGGPGSEGSSGPGESS | 13.6 |
AE576 | 323 | AGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP | 6.1 |
AF540 | 324 | GSTSSTAESPGPGSTSSTAESPGPGSTSESPSGTAPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAP | 8.8 |
AF504 | 325 | GASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSP | 7.0 |
AE864 | 326 | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAP | 6.1 |
AF864 | 327 | GSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGPXXXGASASGAPSTXXXXSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSTSESPSGTAPGTSTPESGSASPGSTSSTAESPGPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSP | 7.5 |
AG868 | 328 | GGSPGASPGTSSTGSPGSSPSASTGTGPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSNPSASTGTGPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSSPSASTGTGPGASPGTSSTGSPGASPGTSSTGSPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSSPSASTGTGPGTPGSGTASSSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSP | 7.5 |
AM875 | 329 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP | 4.5 |
AM1296 | 330 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGPEPTGPAPSGGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGSTSESPSGTAPGSTSESPSGTAPGTSPSGESSTAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSPSGESSTAPGTSPSGESSTAPGTSPSGESSTAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGSSTPSGATGSPGASPGTSSTGSPGASASGAPSTGGTSPSGESSTAPGSTSSTAESPGPGTSPSGESSTAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSSPSASTGTGPGSSTPSGATGSPGASPGTSSTGSPGTSTPESGSASPGTSPSGESSTAPGTSPSGESSTAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGSSTPSGATGSPGASPGTSSTGSPGSSTPSGATGSPGSTSESPSGTAPGTSPSGESSTAPGSTSSTAESPGPGSSTPSGATGSPGASPGTSSTGSPGTPGSGTASSSPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAP | 4.5 |
9聚體肽序列之TEPITOPE評分可藉由添加口袋電勢來計算,如藉由Sturniolo描述[Sturniolo, T.,等人 (1999) Nat Biotechnol, 17: 555]。在本實例中,計算個別HLA對偶基因之單獨Tepitope評分。為了計算具有序列P1-P2-P3-P4-P5-P6-P7-P8-P9之肽的TEPITOPE評分,添加
表 12中之相應個別口袋電勢。具有序列FDKLPRTSG(SEQ ID NO: 271)之9聚體肽之HLA*0101B評分將為0、-1.3、0、0.9、0、-1.8、0.09、0、0之總和。
為評定較長肽之TEPITOPE評分,吾人可針對所有9聚體序列來重複該過程。可針對由其他HLA對偶基因編碼之蛋白質重複此過程。表13至表16給出高加索人群體中高頻率出現之HLA對偶基因之蛋白質產物的口袋電勢。
藉由此方法計算之TEPITOPE評分在約-10至+10範圍內。然而,P1位置缺乏疏水性胺基酸(FKLMVWY(SEQ ID NO: 272))之9聚體肽已計算出的TEPITOPE評分在-1009至-989範圍內。此值在生物學上無意義,且反映以下事實:疏水性胺基酸充當HLA結合之錨定殘基,且P1中缺乏疏水性殘基之肽視為HLA之非結合物。因為大部分XTEN序列缺乏疏水性殘基,所以9聚體子序列之所有組合將具有在-1009至-989範圍內之TEPITOPE。此方法證實XTEN多肽可具有極少或不具有預測之T細胞抗原決定基。
表12:HLA*0101B對偶基因之口袋電勢.
表13:HLA*0301B對偶基因之口袋電勢.
表14:HLA*0401B對偶基因之口袋電勢.
表15:HLA*0701B對偶基因之口袋電勢.
表16:HLA*1501B對偶基因之口袋電勢.
表17:BP之例示性生物活性、例示性分析及較佳指示
表18:連接至XTEN之例示性BPXTEN
*序列名稱反映BP及XTEN組分之N端至C端組態
表B.例示之XTEN化IL-12構築體及參考構築體之DNA及胺基酸序列.
胺基酸 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
A | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
C | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
D | -999 | -1.3 | -1.3 | -2.4 | - | -2.7 | -2 | - | -1.9 |
E | -999 | 0.1 | -1.2 | -0.4 | - | -2.4 | -0.6 | - | -1.9 |
F | 0 | 0.8 | 0.8 | 0.08 | - | -2.1 | 0.3 | - | -0.4 |
G | -999 | 0.5 | 0.2 | -0.7 | - | -0.3 | -1.1 | - | -0.8 |
H | -999 | 0.8 | 0.2 | -0.7 | - | -2.2 | 0.1 | - | -1.1 |
I | -1 | 1.1 | 1.5 | 0.5 | - | -1.9 | 0.6 | - | 0.7 |
K | -999 | 1.1 | 0 | -2.1 | - | -2 | -0.2 | - | -1.7 |
L | -1 | 1 | 1 | 0.9 | - | -2 | 0.3 | - | 0.5 |
M | -1 | 1.1 | 1.4 | 0.8 | - | -1.8 | 0.09 | - | 0.08 |
N | -999 | 0.8 | 0.5 | 0.04 | - | -1.1 | 0.1 | - | -1.2 |
P | -999 | -0.5 | 0.3 | -1.9 | - | -0.2 | 0.07 | - | -1.1 |
Q | -999 | 1.2 | 0 | 0.1 | - | -1.8 | 0.2 | - | -1.6 |
R | -999 | 2.2 | 0.7 | -2.1 | - | -1.8 | 0.09 | - | -1 |
S | -999 | -0.3 | 0.2 | -0.7 | - | -0.6 | -0.2 | - | -0.3 |
T | -999 | 0 | 0 | -1 | - | -1.2 | 0.09 | - | -0.2 |
V | -1 | 2.1 | 0.5 | -0.1 | - | -1.1 | 0.7 | - | 0.3 |
W | 0 | -0.1 | 0 | -1.8 | - | -2.4 | -0.1 | - | -1.4 |
Y | 0 | 0.9 | 0.8 | -1.1 | - | -2 | 0.5 | - | -0.9 |
胺基酸 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
A | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
C | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
D | -999 | -1.3 | -1.3 | 2.3 | - | -2.4 | -0.6 | - | -0.6 |
E | -999 | 0.1 | -1.2 | -1 | - | -1.4 | -0.2 | - | -0.3 |
F | -1 | 0.8 | 0.8 | -1 | - | -1.4 | 0.5 | - | 0.9 |
G | -999 | 0.5 | 0.2 | 0.5 | - | -0.7 | 0.1 | - | 0.4 |
H | -999 | 0.8 | 0.2 | 0 | - | -0.1 | -0.8 | - | -0.5 |
I | 0 | 1.1 | 1.5 | 0.5 | - | 0.7 | 0.4 | - | 0.6 |
K | -999 | 1.1 | 0 | -1 | - | 1.3 | -0.9 | - | -0.2 |
L | 0 | 1 | 1 | 0 | - | 0.2 | 0.2 | - | -0 |
M | 0 | 1.1 | 1.4 | 0 | - | -0.9 | 1.1 | - | 1.1 |
N | -999 | 0.8 | 0.5 | 0.2 | - | -0.6 | -0.1 | - | -0.6 |
P | -999 | -0.5 | 0.3 | -1 | - | 0.5 | 0.7 | - | -0.3 |
Q | -999 | 1.2 | 0 | 0 | - | -0.3 | -0.1 | - | -0.2 |
R | -999 | 2.2 | 0.7 | -1 | - | 1 | -0.9 | - | 0.5 |
S | -999 | -0.3 | 0.2 | 0.7 | - | -0.1 | 0.07 | - | 1.1 |
T | -999 | 0 | 0 | -1 | - | 0.8 | -0.1 | - | -0.5 |
V | 0 | 2.1 | 0.5 | 0 | - | 1.2 | 0.2 | - | 0.3 |
W | -1 | -0.1 | 0 | -1 | - | -1.4 | -0.6 | - | -1 |
Y | -1 | 0.9 | 0.8 | -1 | - | -1.4 | -0.1 | - | 0.3 |
胺基酸 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
A | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
C | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
D | -999 | -1.3 | -1.3 | 1.4 | - | -1.1 | -0.3 | - | -1.7 |
E | -999 | 0.1 | -1.2 | 1.5 | - | -2.4 | 0.2 | - | -1.7 |
F | 0 | 0.8 | 0.8 | -0.9 | - | -1.1 | -1 | - | -1 |
G | -999 | 0.5 | 0.2 | -1.6 | - | -1.5 | -1.3 | - | -1 |
H | -999 | 0.8 | 0.2 | 1.1 | - | -1.4 | 0 | - | 0.08 |
I | -1 | 1.1 | 1.5 | 0.8 | - | -0.1 | 0.08 | - | -0.3 |
K | -999 | 1.1 | 0 | -1.7 | - | -2.4 | -0.3 | - | -0.3 |
L | -1 | 1 | 1 | 0.8 | - | -1.1 | 0.7 | - | -1 |
M | -1 | 1.1 | 1.4 | 0.9 | - | -1.1 | 0.8 | - | -0.4 |
N | -999 | 0.8 | 0.5 | 0.9 | - | 1.3 | 0.6 | - | -1.4 |
P | -999 | -0.5 | 0.3 | -1.6 | - | 0 | -0.7 | - | -1.3 |
Q | -999 | 1.2 | 0 | 0.8 | - | -1.5 | 0 | - | 0.5 |
R | -999 | 2.2 | 0.7 | -1.9 | - | -2.4 | -1.2 | - | -1 |
S | -999 | -0.3 | 0.2 | 0.8 | - | 1 | -0.2 | - | 0.7 |
T | -999 | 0 | 0 | 0.7 | - | 1.9 | -0.1 | - | -1.2 |
V | -1 | 2.1 | 0.5 | -0.9 | - | 0.9 | 0.08 | - | -0.7 |
W | 0 | -0.1 | 0 | -1.2 | - | -1 | -1.4 | - | -1 |
Y | 0 | 0.9 | 0.8 | -1.6 | - | -1.5 | -1.2 | - | -1 |
胺基酸 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
A | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
C | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
D | -999 | -1.3 | -1.3 | -1.6 | - | -2.5 | -1.3 | - | -1.2 |
E | -999 | 0.1 | -1.2 | -1.4 | - | -2.5 | 0.9 | - | -0.3 |
F | 0 | 0.8 | 0.8 | 0.2 | - | -0.8 | 2.1 | - | 2.1 |
G | -999 | 0.5 | 0.2 | -1.1 | - | -0.6 | 0 | - | -0.6 |
H | -999 | 0.8 | 0.2 | 0.1 | - | -0.8 | 0.9 | - | -0.2 |
I | -1 | 1.1 | 1.5 | 1.1 | - | -0.5 | 2.4 | - | 3.4 |
K | -999 | 1.1 | 0 | -1.3 | - | -1.1 | 0.5 | - | -1.1 |
L | -1 | 1 | 1 | -0.8 | - | -0.9 | 2.2 | - | 3.4 |
M | -1 | 1.1 | 1.4 | -0.4 | - | -0.8 | 1.8 | - | 2 |
N | -999 | 0.8 | 0.5 | -1.1 | - | -0.6 | 1.4 | - | -0.5 |
P | -999 | -0.5 | 0.3 | -1.2 | - | -0.5 | -0.2 | - | -0.6 |
Q | -999 | 1.2 | 0 | -1.5 | - | -1.1 | 1.1 | - | -0.9 |
R | -999 | 2.2 | 0.7 | -1.1 | - | -1.1 | 0.7 | - | -0.8 |
S | -999 | -0.3 | 0.2 | 1.5 | - | 0.6 | 0.4 | - | -0.3 |
T | -999 | 0 | 0 | 1.4 | - | -0.1 | 0.9 | - | 0.4 |
V | -1 | 2.1 | 0.5 | 0.9 | - | 0.1 | 1.6 | - | 2 |
W | 0 | -0.1 | 0 | -1.1 | - | -0.9 | 1.4 | - | 0.8 |
Y | 0 | 0.9 | 0.8 | -0.9 | - | -1 | 1.7 | - | 1.1 |
胺基酸 | P1 | P2 | P3 | P4 | P5 | P6 | P7 | P8 | P9 |
A | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
C | -999 | 0 | 0 | 0 | - | 0 | 0 | - | 0 |
D | -999 | -1.3 | -1.3 | -0.4 | - | -0.4 | -0.7 | - | -1.9 |
E | -999 | 0.1 | -1.2 | -0.6 | - | -1 | -0.7 | - | -1.9 |
F | -1 | 0.8 | 0.8 | 2.4 | - | -0.3 | 1.4 | - | -0.4 |
G | -999 | 0.5 | 0.2 | 0 | - | 0.5 | 0 | - | -0.8 |
H | -999 | 0.8 | 0.2 | 1.1 | - | -0.5 | 0.6 | - | -1.1 |
I | 0 | 1.1 | 1.5 | 0.6 | - | 0.05 | 1.5 | - | 0.7 |
K | -999 | 1.1 | 0 | -0.7 | - | -0.3 | -0.3 | - | -1.7 |
L | 0 | 1 | 1 | 0.5 | - | 0.2 | 1.9 | - | 0.5 |
M | 0 | 1.1 | 1.4 | 1 | - | 0.1 | 1.7 | - | 0.08 |
N | -999 | 0.8 | 0.5 | -0.2 | - | 0.7 | 0.7 | - | -1.2 |
P | -999 | -0.5 | 0.3 | -0.3 | - | -0.2 | 0.3 | - | -1.1 |
Q | -999 | 1.2 | 0 | -0.8 | - | -0.8 | -0.3 | - | -1.6 |
R | -999 | 2.2 | 0.7 | 0.2 | - | 1 | -0.5 | - | -1 |
S | -999 | -0.3 | 0.2 | -0.3 | - | 0.6 | 0.3 | - | -0.3 |
T | -999 | 0 | 0 | -0.3 | - | -0 | 0.2 | - | -0.2 |
V | 0 | 2.1 | 0.5 | 0.2 | - | -0.3 | 0.3 | - | 0.3 |
W | -1 | -0.1 | 0 | 0.4 | - | -0.4 | 0.6 | - | -1.4 |
Y | -1 | 0.9 | 0.8 | 2.5 | - | 0.4 | 0.7 | - | -0.9 |
生物活性蛋白 | 生物活性 | 例示性活性分析 | 較佳指示: |
IL-1受體拮抗劑(阿那白滯素;可溶性介白素-1受體;IRAP;KINERET;ANTRIL) | 結合IL1受體而不活化靶細胞;抑制IL1-α與IL1-β之結合;且中和IL1-α及IL1-β之生物活性。 | IL-1與YT-NCI或C3H/HeJ細胞中之IL-1受體結合之競爭(Carter等人, Nature 344: 633-638, 1990);抑制IL-1誘導之內皮細胞-白細胞黏附(Carter等人, Nature 344: 633-638, 1990);對A375-C6細胞之增殖分析,該細胞為人類黑色素瘤細胞株,對IL-1的抗增殖作用高度敏感(Murai T等人, J. Biol. Chem. 276: 6797-6806, 2001)。 | 自體免疫性疾病;關節炎;類風濕性關節炎;哮喘;糖尿病;糖尿病;GVHD;發炎性腸病;克羅恩氏病;眼部炎症;牛皮癬;敗血性休克;移植排斥反應;發炎性病症;風濕性病症;骨質疏鬆症;絕經後骨質疏鬆症;中風。 |
IL-10受體促效劑 | 結合IL10受體;促進IL-10R1與IL-10R2之間的相互作用,從而引起產生抗炎反應之下游信號傳導。 | 構形變化介導介白素-10受體2(IL-10R2)與IL-10結合及信號傳導錯合物的組裝(Yoon S.等人, J. Biol. Chem. 281: 35088 -35096, 2006)。 | 自體免疫性疾病;關節炎;類風濕性關節炎;哮喘;糖尿病;糖尿病;GVHD;發炎性腸病;克羅恩氏病;眼部炎症;牛皮癬;敗血性休克;移植排斥反應;發炎性病症;風濕性病症;骨質疏鬆症;絕經後骨質疏鬆症。 |
BPXTEN 名稱 * | SEQ ID NO: | 序列 |
IL-1ra-AE864 | 331 | MRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDEGGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
IL-1ra-AM875 | 332 | MRPSGRKSSKMQAFRIWDVNQKTFYLRNNQLVAGYLQGPNVNLEEKIDVVPIEPHALFLGIHGGKMCLSCVKSGDETRLQLEAVNITDLSENRKQDKRFAFIRSDSGPTTSFESAACPGWFLCTAMEADQPVSLTNMPDEGVMVTKFYFQEDEGGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP |
IL-10-AE864 | 333 | MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP |
AM875-IL-10 | 334 | GTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGSTSESPSGTAPGTSTPESGSASPGTSTPESGSASPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSSTPSGATGSPGTPGSGTASSSPGSSTPSGATGSPGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGASASGAPSTGGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSTSSTAESPGPGSTSESPSGTAPGTSPSGESSTAPGTPGSGTASSSPGSSTPSGATGSPGSSPSASTGTGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGSTSSTAESPGPGSTSSTAESPGPGTSPSGESSTAPGSEPATSGSETPGSEPATSGSETPGTSTEPSEGSAPGSTSSTAESPGPGTSTPESGSASPGSTSESPSGTAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSSTPSGATGSPGSSPSASTGTGPGASPGTSSTGSPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAP MHSSALLCCLVLLTGVRASPGQGTQSENSCTHFPGNLPNMLRDLRDAFSRVKTFFQMKDQLDNLLLKESLLEDFKGYLGCQALSEMIQFYLEEVMPQAENQDPDIKAHVNSLGENLKTLRLRLRRCHRFLPCENKSKAVEQVKNAFNKLQEKGIYKAMSEFDIFINYIEAYMTMKIRN |
例示之 XTEN 化 IL- 12 構築體(N端His標籤係視情況存在的) | DNA 序列 SEQ ID NO: 1 | GCATCACATCATCACCATCACCATCACCATGGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCAX’GGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCGGCGGCGGCTCTGGCGGCGGCGGCTCCGGCGGCGGCGGCTCCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCC (其中 X' 為如表 6 或 7 中所闡述之編碼釋放區段的聚核苷酸序列 ) |
例示之 XTEN 化 IL- 12 構築體(N端His標籤係視情況存在的) | 胺基酸序列 SEQ ID NO: 2 | ASHHHHHHHHGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPXGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGGGGSGGGGSGGGGSRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA (其中 X 為如表 6 或 7 中所闡述之胺基酸序列(釋放區段 )) |
參考構築體(C端His標籤係視情況存在的) | DNA 序列 ( SEQ ID NO: 3 ) | ATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCGGCGGCGGCTCTGGCGGCGGCGGCTCCGGCGGCGGCGGCTCCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCCATCATCACCATCACCATCACCAT |
參考構築體(C端His標籤係視情況存在的) | 胺基酸序列 SEQ ID NO: 4 | MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGGGGSGGGGSGGGGSRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAHHHHHHHH |
如上文在
表 B中所示,位於各例示之融合蛋白之C端或N端處的聚組胺酸標籤(His標籤)係視情況存在的。
實例 8 : IL 12 活性分析
HEK-Blue IL12報導細胞購自InvivoGen且在37℃、5% CO
2下在由DMEM、4.5 g/l葡萄糖、2 mM L-麩醯胺酸、10%(v/v)熱滅活胎牛血清、100 U/ml青黴素、100 μg/ml鏈黴素、100 μg/mlNormocin、1×HEK-Blue Selection組成的培養基中培養。對於IL12活性分析,如按照前一句所描述製備測試培養基,但不含Normocin及Selection抗生素。使測試培養基及1×PBS在水浴中升溫至37℃。藉由用預溫熱之PBS洗滌燒瓶,然後將細胞自燒瓶移走,接著在室溫下以300×g(1200 rpm)離心5分鐘,測定細胞存活率及將測試培養基中之細胞集結粒再懸浮至0.833×10e6個細胞/毫升。將九十微升(90 µL)細胞等分至96孔平透明底板(Costar,cat#3595)之各孔中。IL12測試物品在測試培養基中以10X濃度製備,其中17 nM為最高濃度,接著連續10倍稀釋至1.7 pM。隨後,將10uL 10×溶液添加至90 µL細胞中,且將板24小時培育。次日,藉由在室溫MilliQ水中將QB試劑及QB緩衝劑各自稀釋至1%(v/v)濃度來製備QuantiBlue溶液,其為分泌胚胎鹼性磷酸酶(SEAP)之偵測試劑。將混合物在室溫下培育10分鐘。隨後,將180 μL等分至96孔平底組織培養板之各孔中,且添加20 μL上清液至各孔中。在37℃、5% CO
2下培育板6小時。在不同培育時間間隔(15分鐘、30分鐘、1小時、2小時、3小時)下,使用微量盤讀取器量測650 nm處之光密度(O.D.)。藉由Excel軟體分析結果且在此自3小時時間點呈現。
如
圖 8中所示,回應於IL-12誘導之STAT4活化而產生分泌胚胎鹼性磷酸酶(SEAP)的IL-12報導細胞用增加濃度之IL-12測試物品處理24小時。使用QuantiBlue溶液量測上清液中之SEAP水準,且在650 nm之光學密度下讀取板。XTEN化IL12(SEQ ID NO: 2)組合物曲線(三角形)相對於相應去XTEN化IL12組合物曲線(菱形)偏移至少2倍,指示XTEN之掩蔽效應降低了細胞介素活性。
實例 9 : IL 12 受體結合分析
表現人類IL-12受體之HEK-Blue IL-12報導細胞(Invivogen,如實例8中所描述)用於評估IL-12構築體與IL-12受體之結合。將含有具有N端his標籤外加XTEN序列繼之以釋放區段序列之重組單鏈小鼠IL12的例示「
XTEN 化 IL 12」構築體(
SEQ ID NO: 2)(1 µM)之濃度增加,將其與隨後洗滌之50,000個293HEK-IL-12報導細胞一起培育,且藉由流式細胞測量術使用用於偵測之抗His標籤抗體螢光標記之螢光測量術監測表面結合之IL12。比較藉由XTEN化IL12之結合與含有重組單鏈小鼠IL-12及C端His標籤之參考IL-12構築體
( SEQ ID NO: 4)的結合。由於在用人類基質金屬肽酶9(MMP9)活化之後來自XTEN化IL-12釋放出His標籤,吾人不能評估IL-12在此分析中其活化形式之結合。藉由MMP9裂解釋放之XTEN片段保留His標籤,且用作結合之特異性對照。如
圖 9 A 至圖 9 B中所示,XTEN當存在於融合蛋白中時掩蔽細胞介素與其相應IL12受體之結合。當不連接至XTEN時,XTEN化IL-12展現出相比於IL12之相應結合活性降低的結合親和力,如藉由半最大有效濃度(EC50)中的增加所表徵。
實例 10 :例示性 Xten 化 IL 12 構築體
在某些例示性實施例中,使用已XTEN化四次之IL12次單元產生XTEN化IL12構築體。下表提供已XTEN化之例示性IL12 p35次單元及已XTEN化之IL12 p40次單元的核酸及胺基酸序列。
圖10A及10B展示以上兩種構築體之示意圖。HEK Blue IL12活性分析實質上如以上實例9中所描述進行。來自該等分析之資料在圖10C中整理且呈現於下表19中:
表 19 :使用 HEK Blue 分析報導之 IL 12 活性
EC50 | 掩蔽 | |
muIL12 | 25 | n/a |
(AP2551 XPAC) | 7117 | 430 |
(AP2551 PAC) | 17 | - |
(具有TG標籤之AP2552 XPAC) | 2746 | 95 |
(具有TG標籤之AP2552 PAC) | 29 | - |
此等資料清楚地表明,產生的PAC具有與重組muIL12等效的活性,正如異二聚體製劑的預期,且當不與XTEN連接時,IL12的XTEN化導致結合親和力與IL12的相應結合活性相比有所降低,如藉由半最大有效濃度(EC50)中的增加所表徵。因此,此資料展示IL12-XPAC-4X構築體展現與裸IL12相當的充分掩蔽及活性。此外,轉麩醯胺酸酶標籤之存在不影響IL12活性。
在另一分析中,比較1(AP2450)、3(AP2447)及4(AP2446)XTEN對IL12之效應(圖11A-C及表20)。
EC50(PM) | AP2446-XPAC (4XTEN) | AP2447-XPAC (3XTEN) | AP2450-XPAC (1XTEN) |
9024 | 849.5 | 1171 | |
AP2446-PAC | AP2447-PAC | AP2450-PAC | |
115.2 | 102 | 106.1 | |
摺疊掩蔽 | 78 | 8 | 11 |
關於所產生之資料,可見所有XTEN促進掩蔽,且在單一位點增加XTEN不會提供額外益處,但使用雙質體形式進行表現可提供額外XTEN添加益處。最佳構築體:選擇AP2446、AP2450、AP2407用於進一步研究。
在下一個迭代中,IL12-XPAC-4X構築體經重新設計以探究IL12異二聚體之純化及分析中之每一者的設計。三個構築體之設計展示於下表中,且構築體之示意圖展示於圖12A(由表22中所示之XP5/XP13序列構成之IL12-XPAC-4X.1)、12B(由表22中所示之XP4/XP10序列構成之IL12-XPAC-4X.2)及12C(下表22中所示之XP3/XP9序列構成之IL12-XPAC-4X.3)中作為示意圖,且如下表21所描述:
表 21 :各自包含 4 個 XTEN 序列之三個例示性 IL 12 -XPAC 的特徵
表 22 :表 21 中所示之 XPAC 之例示性 XTEN 化次單元的序列
實例 11 : IL 12 -XPAC- 4 X 測試化合物對小鼠模型之活體內效應
構築體 | 次單元 | 格式 | #XTEN | 總XTEN AA | 次單元大小 (Kda) | 總蛋白大小(Kda) |
IL12-XPAC-4X.1 | 4 | 1152 | 172 | |||
XTEN P40 | X288-P40-X288 | 2 | 93 | |||
XTEN P35 | X288-P35-X288 | 2 | 79 | |||
IL12-XPAC-4X.2 | 4 | 1152 | 172 | |||
AC3244 | X376-P40-X288 | 2 | 101 | |||
AC3247 | X376-P35-X200 | 2 | 71 | |||
IL12-XPAC-4X.3 | 4 | 1152 | 172 | |||
AC3245 | X200-P40-X288 | 2 | 85 | |||
AC3246 | X288-P35-X376 | 2 | 87 |
XP 編號 | DNA 序列 | 蛋白質序列 | 域 |
XP01 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGTGCTGCAGAGCCCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCAGAGATCGTCCTGACCCAATCCCCCGGGACCCTCAGCCTGAGCCCAGGCGAGCGTGCCACTTTGAGCTGTCGTGCATCACAGAGTGTGAGTTCCTCATTCCTGGCTTGGTACCAGCAAAAGCCCGGTCAGGCCCCGAGACTTTTGATTTACTATGCTTCCAGCCGCGCTACCGGGATCCCAGATAGATTTTCTGGGAGCGGTTCTGGTACCGATTTCACTCTGACCATCTCTAGACTCGAACCAGAAGACTTTGCAGTATATTACTGCCAACAGACCGGTCGGATCCCTCCAACTTTCGGACAGGGTACCAAGGTTGAGATCAAGGGTGCAACGCCTCCGGAGACTGGTGCTGAAACTGAGTCCCCGGGCGAGACGACCGGTGGCTCTGCTGAATCCGAACCACCGGGCGAAGGCGAGGTCCAGCTGTTGGAGAGCGGCGGTGGACTCGTGCAGCCGGGCGGTTCACTTCGTCTCAGTTGTGCTGCCTCAGGCTTCACCTTTAGCTCATTCTCAATGAGTTGGGTGAGACAGGCGCCCGGCAAGGGCCTTGAGTGGGTTAGTTCCATTTCCGGCTCCAGCGGCACTACCTACTATGCCGACTCAGTCAAAGGTAGATTTACCATCTCCCGCGATAACTCTAAGAACACCCTGTACCTGCAGATGAACTCCCTCAGGGCAGAGGATACCGCCGTGTACTATTGCGCGAAGCCCTTCCCATACTTCGACTACTGGGGTCAGGGCACCCTGGTCACTGTCAGTTCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCA (SEQ ID NO: 831) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGVLQSPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPEIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIYYASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQTGRIPPTFGQGTKVEIKGATPPETGAETESPGETTGGSAESEPPGEGEVQLLESGGGLVQPGGSLRLSCAASGFTFSSFSMSWVRQAPGKGLEWVSSISGSSGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPFPYFDYWGQGTLVTVSSGTAEAASASGEAGRSANHTPAGLTGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 849) | P40 |
XP02 | ATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA(SEQ ID NO: 832) | MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 850) | P40 |
XP03 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCACAT(SEQ ID NO: 833) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPEAGRSANHTPAGLTGPGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP(SEQ ID NO: 851) | P40 |
XP04 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 834) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEAGRSANHTPAGLTGPGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP(SEQ ID NO: 852) | P40 |
XP05 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 835) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 853) | P40 |
XP06 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 836) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPEAGRSANHTPAGLTGPGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 854) | P40 |
XP07 | GCAAGCTCCGCCACCCCCGAGTCTGGACCAGGCACCAGCACAGAGCCTTCTGAGGGAAGCGCCCCAGGCACAAGCGAGTCCGCCACCCCTGAGTCCGGACCAGGATCTGGACCAGCCACCTCTGAGAGCGCCACACCTGGCACCTCCGAGTCTGCCACACCTGAGAGCGGACCAGGATCCGAGCCAGCCACCAGCGGCTCCGAGACACCAGGCACCTCTGAAAGCGCCACTCCTGAGTCCGGACCAGGCACCTCTACAGAGCCTTCCGAGGGATCTGCCCCAGGAAGCCCAGCAGGCAGCCCAACCTCCACAGAGGAGGGCACATCCGAGTCTGCCACTCCTGAGTCTGGACCTGGAAGCGAGCCAGCCACAAGCGGAAGCGAAACACCAGGCACCTCTGAGAGCGCCACGCCTGAGTCCGGACCTGGATCTCCAGCCGGCTCTCCTACCAGCACAGAGGAGGGATCCCCAGCAGGATCCCCTACCTCTACAGAGGAGGGCACCAGCACAGAGCCAAGCGAGGGATCCGCCCCTGGCACATCCGAATCTGCCACCCCAGAGTCCGGACCTGGCACAAGCGAATCCGCCACCCCTGAGAGCGGACCAGGCACATCTGAGAGCGCCACCCCAGAGAGCGGACCTGGATCCGAGCCAGCCACATCCGGATCTGAGACCCCAGGATCCGAGCCTGCCACAAGCGGATCCGAGACCCCAGGAAGCCCTGCAGGATCTCCCACCAGCACCGAAGAAGGCACCAGCACCGAGCCCAGCGAAGGATCTGCCCCTGGCACCAGCACCGAGCCTAGCGAGGGATCCGCCCCCGGCTCCGAGCCAGCCACCTCTGGAAGTGAAACACCAGGCACCTCCGAATCTGCCACACCAGAGGCAGGCCGGTCCGCCAACCACACCCCAGCAGGACTGACAGGACCAGGCACCAGCGAATCCGCCACTCCAGAGAGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAATCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCCGATCAGAGACACGGCGTGATCGGCTCTGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCTCACAGCCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCAAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGTCTAGCTCCTCTAGCCCAGATAGCAGGGCAGTGACATGCGGAATGGCATCCCTGTCTGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATAGCGTGTCCTGCCAGGAGGACGTGACATGTCCTACCGCCGAGGAGACCCTGCCAATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCTACCAGCTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATAGCCAGGTCGAGGTGTCCTGGGAGTACCCTGACTCCTGGTCTACCCCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAACCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATAGGTACTATAATTCCTCTTGTAGCAAGTGGGCCTGCGTGCCCTGTCGGGTGAGATCTGGCACAGCTACTCCAGAAAGCGGACCAGGAGAGGCAGGCCGCAGCGCCAATCATACTCCTGCCGGACTGACAGGACCTGCAACTCCTGAGTCTGGACCCGGCAGCCCTGCAGGATCCCCCACATCTACCGAAGAAGGATCCCCAGCAGGAAGCCCTACATCCACCGAGGAGGGAAGCCCAGCAGGATCTCCCACAAGCACCGAGGAGGGCACAAGCGAGTCCGCCACGCCTGAGTCTGGACCAGGCACAAGCACCGAGCCATCCGAGGGATCTGCCCCTGGCACATCTGAAAGCGCCACTCCCGAAAGCGGACCTGGATCTGAGCCAGCCACCTCCGGATCTGAGACACCAGGCACCAGCGAGTCCGCCACACCCGAATCCGGCCCAGGCAGCGAACCTGCCACCTCTGGAAGCGAGACCCCAGGCACCTCCGAGTCTGCCACGCCCGAATCCGGACCTGGCACATCTACCGAACCTTCCGAAGGATCCGCCCCTGGCAGCCCAGCAGGATCTCCTACAAGCACTGAAGAGGGCACAAGCGAGTCCGCCACTCCAGAGTCTGGACCAGGAAGCGAGCCTGCCACCTCTGGCAGCGAGACCCCCGGCACCTCCGAGTCTGCCACCCCTGAATCTGGCCCTGGATCTCCAGCCGGGTCCCCCACATCTACCGAGGAAGGCTCCCCAGCAGGAAGCCCCACATCCACTGAAGAAGGCACAAGCACTGAACCATCCGAAGGCAGCGCCCCTGGCACAAGCGAGTCCGCCACACCAGAGTCAGGCCCTGGCACATCTGAGAGCGCCACGCCAGAGAGCGGACCTGGCACATCCCCATCTGCCACTCCTGAGAGTGGCCCCGGGTCTGAACCAGCCACAAGCGGCAGCGAAACTCCTGGCTCCGAGCCTGCCACATCTGGGTCCGAAACTCCTGGCTCCCCAGCCGGCAGCCCCACATCTACTGAGGAGGGCACAAGCACTGAACCCTCCGAGGGATCCGCCCCAGGCACATCTACCGAGCCCTCCGAAGGAAGCGCCCCAGGAAGCGAACCTGCCACCTCCGGCTCCGAAACCCCTGGCACCAGCGAATCCGCCGGAGAGCCTGAGGCC (SEQ ID NO: 837) | ASSATPESGPGTSTEPSEGSAPGTSESATPESGPGSGPATSESATPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPEAGRSANHTPAGLTGPGTSESATPESMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTATPESGPGEAGRSANHTPAGLTGPATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSPSATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAGEPEA (SEQ ID NO: 855) | P40 |
XP08 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTGAACCTGAGGCC (SEQ ID NO: 838) | EPEAGTAEAASASGGTAEAASASGEAGRSANHTPAGLTGPEAGRSANHTPAGLTGPRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGP (SEQ ID NO: 856) | P35 |
XP09 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCAGAACCTGAGGCC(SEQ ID NO: 839) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGEAGRSANHTPAGLTGPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPEPEA (SEQ ID NO: 857) | P35 |
XP10 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTGAACCTGAGGCCTAA(SEQ ID NO: 840) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGEPEA (SEQ ID NO: 858) | P35 |
XP11 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCTAA (SEQ ID NO: 841) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA (SEQ ID NO: 859) | P35 |
XP12 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGTGCTGCAGAGCCCAGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 842) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGVLQSPGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 860) | P35 |
XP13 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 843) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 861) | P35 |
XP14 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA (SEQ ID NO: 844) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPEAGRSANHTPAGLTGPGTAEAASASGRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTAEAASASGEAGRSANHTPAGLTGPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP (SEQ ID NO: 862) | P35 |
XP15 | GCAAGCTCCGCCACCCCTGAGTCTGGACCAGGCACCAGCACAGAGCCTTCCGAGGGATCTGCCCCAGGCACCAGCGAGTCCGCCACACCAGAGTCCGGACCTGGATCTGGACCAGGCACCTCTGAGAGCGCCACCCCAGGCACATCCGAGTCTGCCACCCCAGAGAGCGGACCTGGATCCGAGCCAGCCACAAGCGGATCCGAGACCCCAGGCACATCTGAAAGCGCCACTCCAGAGTCCGGACCTGGCACCTCTACAGAGCCTAGCGAGGGATCCGCCCCTGGAAGCCCAGCCGGCTCTCCTACCAGCACAGAGGAGGGCACCTCCGAGTCTGCCACACCAGAGTCTGGACCAGGAAGCGAGCCTGCCACCAGCGGCAGCGAAACTCCAGGCACATCTGAGAGCGCCACCCCTGAGTCCGGACCAGGATCTCCTGCAGGATCCCCTACCTCTACAGAGGAGGGAAGCCCAGCAGGAAGCCCCACCTCCACCGAAGAGGGCACCTCCACAGAGCCATCTGAGGGAAGCGCCCCTGGCACCTCCGAATCTGCCACACCTGAGTCCGGACCCGGCACCAGCGAATCCGCCACCCCCGAGTCTGGACCTGGCACCTCTGAAAGCGCCACACCAGAGAGCGGACCAGGATCCGAGCCTGCCACCTCCGGATCTGAGACACCAGGAAGCGAGCCAGCCACCAGCGGATCCGAGACACCAGGCTCCCCCGCCGGCTCCCCCACCTCTACAGAGGAGGGCACCAGCACCGAACCTTCCGAGGGATCCGCCCCCGGCACCAGCACCGAGCCTTCCGAAGGAAGCGCCCCAGGCTCCGAGCCAGCCACCTCTGGAAGTGAAACTCCTGGCACATCCGAATCTGCCACCCCAGAGGCAGGCAGGTCCGCCAACCACACACCAGCAGGACTGACCGGACCAGGCACAAGCGAGTCCGCCACCCCAGAGAGCCGCGTGATCCCCGTGTCCGGACCTGCAAGGTGCCTGTCTCAGAGCAGAAATCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACAGCTGTACAGCCGAGGACATCGATCACGAGGACATCACCAGAGATCAGACCAGCACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGTCCTGTCTGGCCACCCGGGAGACATCTAGCACCACAAGAGGCTCTTGCCTGCCCCCTCAGAAGACCAGCCTGATGATGACCCTGTGCCTGGGCAGCATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCATACCGCGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAACCGCGTGATGGGCTATCTGTCCTCTGCCGGCACTGCTACACCAGAGTCCGGACCAGGAGAGGCAGGCCGGTCTGCCAATCACACCCCTGCCGGACTGACCGGACCTGCAACACCAGAGTCTGGACCTGGCTCTGAGCCAGCCACCTCCGGCTCCGAGACCCCTGGCACAAGCGAATCCGCCACCCCAGAAAGCGGCCCTGGCTCCCCAGCCGGCAGCCCTACCTCTACCGAAGAAGGCAGCCCAGCAGGAAGCCCTACCTCCACCGAGGAAGGCACCTCCACAGAGCCTTCTGAGGGAAGCGCCCCCGGCACCTCTGAAAGCGCCACGCCAGAATCCGGACCAGGCACCTCCGAGTCTGCCACGCCTGAGTCCGGACCAGGCACCAGCGCCTCCGCCACACCCGAGAGCGGCCCAGGGAGCGAACCAGCCACCTCTGGAAGCGAAACCCCTGGCAGTGAACCAGCCACCTCCGGCTCTGAGACACCAGGATCCCCAGCCGGCTCACCTACCTCTACCGAGGAGGGCACCAGCACTGAACCTAGTGAGGGATCCGCCCCAGGCACCTCTACCGAACCTAGCGAAGGCAGCGCCCCTGGCTCAGAGCCAGCCACCAGCGGCAGCGAGACTCCTGGCACATCTGAAAGCGCCGGC (SEQ ID NO: 845) | ASSATPESGPGTSTEPSEGSAPGTSESATPESGPGSGPGTSESATPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPEAGRSANHTPAGLTGPGTSESATPESRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTATPESGPGEAGRSANHTPAGLTGPATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSASATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAG (SEQ ID NO: 863) | P35 |
XP16 | ATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCGGCGGCGGCTCTGGCGGCGGCGGCTCCGGCGGCGGCGGCTCCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCCGGCACAGCCGAGGCCGCTAGCGCCAGCGGCGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCA(SEQ ID NO: 846) | MWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTAEAASASGEAGRSANHTPAGLTGPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAP(SEQ ID NO: 864) | IL12 |
XP17 | GGTTCTCCAGCCGGGTCCCCAACTTCGACCGAGGAAGGGACCTCCGAGTCAGCTACCCCGGAGTCCGGTCCTGGCACCTCCACCGAACCATCGGAGGGCAGCGCCCCTGGGAGCCCTGCCGGGAGCCCTACAAGCACCGAAGAGGGCACCAGTACAGAGCCAAGTGAGGGGAGCGCCCCTGGTACTAGTACTGAACCATCCGAGGGGTCAGCTCCAGGCACGAGTGAGTCCGCTACCCCCGAGAGCGGACCGGGCTCAGAGCCCGCCACGAGTGGCAGTGAAACTCCAGGCTCAGAACCCGCCACTAGTGGGTCAGAGACTCCAGGCAGCCCTGCCGGATCCCCTACGTCCACCGAGGAGGGAACATCTGAGTCCGCAACACCCGAATCCGGTCCAGGCACCTCCACGGAACCTAGTGAAGGCTCGGCACCAGGTACAAGCACCGAACCTAGCGAGGGCAGCGCTCCCGGCAGCCCTGCCGGCAGCCCAACCTCAACTGAGGAGGGCACCAGTACTGAGCCCAGCGAGGGATCAGCACCTGGCACCAGCACCGAACCTAGCGAGGGGAGCGCCCCTGGGACTAGCGAGTCAGCTACACCAGAGAGCGGGCCTGGAACTTCTACCGAACCCAGTGAGGGATCCGCTCCAGGCACCTCCGAATCCGCAACCCCCGAATCCGGACCTGGCTCAGAGCCCGCCACCAGCGGGAGCGAAACCCCTGGCACATCCACCGAGCCTAGCGAAGGGTCCGCACCCGGCACCAGTACAGAGCCTAGCGAGGGATCAGCACCTGGCACCAGTGAATCTGCTACACCAGAGAGCGGCCCTGGAACCTCCGAGTCCGCTACCCCCGAGAGCGGGCCAGGTTCTCCTGCTGGCTCCCCCACCTCAACAGAAGAGGGGACAAGCGAAAGCGCTACGCCTGAGAGTGGCCCTGGCTCTGAGCCAGCCACCTCCGGCTCTGAAACCCCTGGCACTAGTGAGTCTGCCACGCCTGAGTCCGGACCCGGGACCTCTACTGAGCCCTCGGAGGGGAGCGCTCCTGGCACGAGTACAGAACCTTCCGAAGGAAGTGCACCGGGCACAAGCACCGAGCCTTCCGAAGGCTCTGCTCCCGGAACCTCTACCGAACCCTCTGAAGGGTCTGCACCCGGCACGAGCACCGAACCCAGCGAAGGGTCAGCGCCTGGGACCTCAACAGAGCCCTCGGAAGGATCAGCGCCTGGAAGCCCTGCAGGGAGTCCAACTTCCACGGAAGAAGGAACGTCTACAGAGCCATCAGAGGGGTCCGCACCAGGTACCAGCGAATCCGCTACTCCCGAATCTGGCCCTGGGTCCGAACCTGCCACCTCCGGCTCTGAAACTCCAGGGACCTCCGAATCTGCCACACCCGAGAGCGGCCCTGGCTCCGAGCCCGCAACATCTGGCAGCGAGACACCTGGCACCTCCGAGAGCGCAACACCCGAGAGCGGCCCTGGCACCAGCACCGAGCCATCCGAGGGATCCGCCCCAGGCACTTCTGAGTCAGCCACACCCGAAAGCGGACCAGGATCACCCGCTGGCTCCCCCACCAGTACCGAGGAGGGGTCCCCCGCTGGAAGTCCAACAAGCACTGAGGAAGGGTCCCCTGCCGGCTCCCCCACAAGTACCGAAGAGGGCACAAGTGAGAGCGCCACTCCCGAGTCCGGGCCTGGCACCAGCACAGAGCCTTCCGAGGGGTCCGCACCAGGTACCTCAGAGTCTGCTACCCCCGAGTCAGGGCCAGGATCAGAGCCAGCCACCTCCGGGTCTGAGACACCCGGGACTTCCGAGAGTGCCACCCCTGAGTCCGGACCCGGGTCCGAGCCCGCCACTTCCGGCTCCGAAACTCCCGGCACAAGCGAGAGCGCTACCCCAGAGTCAGGACCAGGAACATCTACAGAGCCCTCTGAAGGCTCCGCTCCAGGGTCCCCAGCCGGCAGTCCCACTAGCACCGAGGAGGGAACCTCTGAAAGCGCCACACCCGAATCAGGGCCAGGGTCTGAGCCTGCTACCAGCGGCAGCGAGACACCAGGCACCTCTGAGTCCGCCACACCAGAGTCCGGACCCGGATCTCCCGCTGGGAGCCCCACCTCCACTGAGGAGGGATCTCCTGCTGGCTCTCCAACATCTACTGAGGAAGGTACCTCAACCGAGCCATCCGAGGGATCAGCTCCCGGCACCTCAGAGTCGGCAACCCCGGAGTCTGGACCCGGAACTTCCGAAAGTGCCACACCAGAGTCCGGTCCCGGGACTTCAGAATCAGCAACACCCGAGTCCGGCCCTGGGTCTGAACCCGCCACAAGTGGTAGTGAGACACCAGGATCAGAACCTGCTACCTCAGGGTCAGAGACACCCGGATCTCCGGCAGGCTCACCAACCTCCACTGAGGAGGGCACCAGCACAGAACCAAGCGAGGGCTCCGCACCCGGAACAAGCACTGAACCCAGTGAGGGTTCAGCACCCGGCTCTGAGCCGGCCACAAGTGGCAGTGAGACACCCGGCACTTCAGAGAGTGCCACCCCCGAGAGTGGCCCAGGCACTAGTACCGAGCCCTCTGAAGGCAGTGCGCCAGAGGCCGGCCGGAGCGCCAACCACACCCCCGCCGGCCTGACCGGCCCTGGCACAGCCGAGGCCGCTAGCGCCAGCGGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCAGATGCCCCCGGCGAGACCGTGAACCTGACATGCGACACCCCCGAGGAGGACGATATCACCTGGACATCTGATCAGAGGCACGGCGTGATCGGAAGCGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCCCACTCTCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCTAATTATAGCGGCCGGTTCACCTGTTCCTGGCTGGTGCAGAGAAACATGGACCTGAAGTTTAATATCAAGAGCTCCTCTAGCTCCCCAGATAGCCGGGCAGTGACATGCGGAATGGCCAGCCTGTCCGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATTCTGTGAGCTGCCAGGAGGACGTGACATGTCCCACCGCCGAGGAGACACTGCCTATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCCACCTCTTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTCGAGGTGTCTTGGGAGTACCCTGACAGCTGGTCCACACCACACTCTTATTTCAGCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAATCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATCGGTACTATAATTCTAGCTGTTCCAAGTGGGCCTGCGTGCCTTGTCGGGTGAGATCTGGCGGCGGCGGCTCTGGCGGCGGCGGCTCCGGCGGCGGCGGCTCCAGAGTGATCCCCGTGAGCGGACCAGCAAGGTGCCTGTCCCAGAGCCGGAACCTGCTGAAGACCACAGACGATATGGTGAAGACCGCCCGGGAGAAGCTGAAGCACTACTCTTGTACAGCCGAGGACATCGATCACGAGGACATCACCCGGGATCAGACCTCTACACTGAAGACATGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACCCGGGAGACAAGCTCCACCACAAGAGGCAGCTGCCTGCCCCCTCAGAAGACCTCCCTGATGATGACCCTGTGCCTGGGCTCTATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGAGCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCACCAGTGGGAGAGGCAGATCCTTACAGGGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTTCCACCAGGGTGGTGACAATCAATCGCGTGATGGGCTATCTGTCTAGCGCC(SEQ ID NO: 847) | GSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSTEPSEGSAPGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGTSTEPSEGSAPGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPEAGRSANHTPAGLTGPGTAEAASASGMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGGGGSGGGGSGGGGSRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSA (SEQ ID NO: 865) | IL12 |
XP18 | GCAAGCTCCGCCACCCCAGAGTCCGGACCTGGCACCTCTACAGAGCCAAGCGAGGGATCCGCCCCAGGCACAAGCGAGTCCGCCACCCCAGAGTCTGGACCAGGAAGCGGACCTGCCACCTCTGAGAGCGCCACACCAGGCACCTCCGAGTCTGCCACACCAGAGTCCGGACCAGGATCTGAGCCTGCCACCAGCGGATCCGAGACACCTGGCACCTCTGAAAGCGCCACTCCAGAGAGCGGACCAGGCACCTCCACCGAGCCTTCTGAGGGAAGCGCCCCAGGAAGCCCTGCAGGATCCCCAACCTCTACAGAGGAGGGCACATCCGAGTCTGCCACCCCTGAGAGCGGACCAGGATCCGAGCCAGCCACAAGCGGATCCGAGACACCAGGCACCTCTGAGAGCGCCACGCCTGAATCCGGACCAGGAAGCCCAGCAGGAAGCCCCACCTCCACAGAGGAGGGATCCCCTGCAGGATCTCCAACCAGCACAGAGGAGGGCACCAGCACAGAGCCTTCCGAGGGCTCTGCCCCAGGCACATCCGAATCTGCCACTCCTGAGTCTGGACCTGGCACAAGCGAATCCGCCACCCCCGAAAGCGGACCAGGCACATCTGAGAGCGCCACCCCTGAGTCTGGCCCAGGATCTGAGCCAGCCACATCCGGCTCTGAGACCCCTGGCAGCGAACCTGCCACAAGCGGCAGCGAGACCCCTGGAAGCCCAGCAGGCTCCCCCACCTCCACCGAAGAAGGCACCAGCACAGAGCCATCTGAGGGAAGCGCCCCTGGCACCAGCACCGAACCATCCGAGGGATCTGCCCCAGGATCCGAGCCTGCCACCTCTGGCAGTGAAACCCCTGGCACCTCCGAATCTGCCACACCCGAGGCAGGCCGGTCCGCCAACCACACCCCAGCCGGCCTGACAGGACCTGGCACCAGCGAATCCGCCACTCCAGAGAGCATGTGGGAGCTGGAGAAGGACGTGTACGTGGTGGAGGTGGACTGGACACCCGATGCCCCTGGCGAGACCGTGAATCTGACATGCGACACCCCTGAGGAGGACGATATCACCTGGACATCCGATCAGAGACACGGCGTGATCGGCTCTGGCAAGACCCTGACAATCACCGTGAAGGAGTTCCTGGATGCCGGCCAGTACACATGTCACAAGGGCGGCGAGACCCTGTCTCACAGCCACCTGCTGCTGCACAAGAAGGAGAACGGCATCTGGTCCACAGAGATCCTGAAGAACTTCAAGAATAAGACCTTTCTGAAGTGCGAGGCCCCCAATTATAGCGGCAGGTTCACCTGTTCCTGGCTGGTGCAGCGCAACATGGACCTGAAGTTTAATATCAAGTCTAGCTCCTCTAGCCCTGATAGCAGGGCAGTGACATGCGGAATGGCATCCCTGTCTGCCGAGAAGGTGACCCTGGACCAGAGAGATTACGAGAAGTATAGCGTGTCCTGCCAGGAGGACGTGACATGTCCTACCGCCGAGGAGACCCTGCCAATCGAGCTGGCCCTGGAGGCCAGGCAGCAGAACAAGTACGAGAATTATTCTACCAGCTTCTTTATCCGCGACATCATCAAGCCAGATCCCCCTAAGAACCTGCAGATGAAGCCCCTGAAGAATTCCCAGGTGGAGGTGAGCTGGGAGTACCCAGACTCCTGGTCTACCCCCCACAGCTATTTCTCCCTGAAGTTCTTTGTGAGGATCCAGCGCAAGAAGGAGAAGATGAAGGAGACCGAGGAGGGCTGCAACCAGAAGGGCGCCTTTCTGGTGGAGAAGACATCCACCGAGGTGCAGTGCAAGGGAGGAAACGTGTGCGTGCAGGCACAGGATAGGTACTATAATTCCTCTTGTAGCAAGTGGGCATGCGTGCCATGTCGGGTGAGATCCGGCACAGCTACTCCTGAATCTGGACCAGGAGAGGCAGGCCGCAGCGCCAACCACACCCCTGCAGGACTGACAGGACCAGCAACCCCAGAGAGCGGACCTGGATCCCCAGCCGGCTCTCCAACAAGCACCGAAGAAGGATCTCCAGCAGGATCCCCAACATCTACCGAGGAGGGCTCCCCAGCAGGAAGCCCTACATCCACCGAGGAGGGCACAAGCGAGTCCGCCACGCCAGAGTCCGGACCAGGCACATCTACCGAACCAAGCGAAGGAAGCGCCCCTGGCACATCTGAAAGCGCCACTCCCGAAAGCGGACCAGGAAGCGAGCCAGCCACCTCCGGATCTGAGACACCAGGCACCAGCGAGTCCGCCACACCTGAGTCTGGGCCTGGCTCTGAGCCAGCCACCTCTGGAAGTGAAACCCCCGGCACCTCCGAGTCTGCCACGCCTGAGAGCGGACCAGGCACATCCACCGAGCCTAGCGAAGGCTCTGCCCCTGGCAGCCCTGCCGGCTCCCCTACATCCACTGAGGAGGGCACAAGCGAGTCCGCCACTCCTGAAAGCGGACCTGGATCCGAACCTGCCACCTCTGGAAGTGAGACCCCTGGCACCTCCGAGTCTGCCACCCCCGAATCTGGCCCTGGCTCCCCAGCAGGCTCTCCCACAAGCACCGAGGAGGGATCCCCAGCAGGATCCCCTACATCTACTGAAGAGGGCACAAGCACCGAACCTAGCGAGGGATCCGCCCCTGGCACAAGCGAGTCCGCCACACCCGAATCTGGCCCCGGCACATCTGAAAGCGCCACGCCAGAATCCGGCCCAGGCACATCCCCATCTGCCACCCCTGAGTCTGGGCCTGGGTCTGAACCTGCCACAAGCGGGAGCGAGACCCCTGGCAGCGAGCCAGCCACATCTGGATCCGAAACTCCAGGCTCCCCAGCAGGATCCCCCACAAGCACTGAAGAAGGCACAAGCACCGAGCCTAGCGAGGGGTCTGCCCCTGGCACATCTACCGAGCCCTCCGAAGGCTCCGCCCCAGGAAGCGAGCCTGCCACCTCCGGCTCTGAGACACCTGGCACCAGCGAGTCCGCCGGAGCCTCCTCCGCCACTCCTGAATCCGGACCTGGCACAAGCACTGAACCTTCCGAAGGAAGCGCCCCCGGCACATCTGAGAGCGCCACTCCAGAATCCGGACCAGGATCCGGCCCCGGCACCTCCGAGTCTGCCACTCCCGGCACCAGCGAATCCGCCACGCCTGAGTCCGGCCCTGGGAGCGAACCCGCCACCTCTGGAAGCGAAACCCCAGGCACCTCCGAATCTGCCACGCCTGAGTCTGGCCCAGGCACATCTACTGAACCTAGCGAAGGGTCTGCCCCTGGGAGCCCTGCAGGCAGCCCCACATCCACAGAAGAAGGCACAAGCGAATCCGCCACACCTGAGTCCGGACCTGGATCCGAGCCCGCCACCTCTGGCTCCGAAACTCCTGGCACCTCCGAGTCTGCCACGCCGGAATCTGGACCAGGATCTCCTGCCGGATCCCCCACAAGCACAGAAGAAGGGAGCCCTGCCGGATCCCCTACATCTACAGAAGAGGGCACAAGCACTGAGCCCTCCGAAGGGTCCGCCCCCGGCACAAGCGAGTCCGCCACGCCGGAAAGTGGCCCTGGCACATCTGAGAGCGCCACACCCGAGTCTGGGCCAGGCACATCCGAGTCTGCCACGCCAGAGTCTGGACCTGGAAGTGAACCCGCCACAAGCGGCTCCGAGACTCCTGGCAGCGAGCCTGCCACATCTGGATCCGAGACTCCTGGAAGCCCAGCAGGATCACCCACAAGCACTGAGGAGGGCACATCCACCGAGCCCAGCGAGGGATCTGCCCCTGGCACATCCACAGAACCTTCCGAAGGATCCGCCCCTGGCTCCGAACCTGCCACCTCCGGGAGCGAAACCCCAGGCACCAGCGAATCCGCCACCCCAGAGGCAGGCCGGAGCGCCAACCACACCCCCGCTGGACTGACCGGCCCTGGCACCTCTGAGAGCGCCACCCCAGAGTCTAGAGTGATCCCTGTGAGCGGACCAGCAAGGTGCCTGTCCCAGTCTAGAAATCTGCTGAAGACCACAGACGATATGGTGAAGACAGCCAGGGAGAAGCTGAAGCACTACAGCTGTACCGCCGAGGACATCGATCACGAGGACATCACACGCGATCAGACATCCACCCTGAAGACCTGCCTGCCCCTGGAGCTGCACAAGAACGAGAGCTGTCTGGCCACACGGGAGACCTCTAGCACCACAAGAGGCAGCTGCCTGCCACCCCAGAAGACATCCCTGATGATGACCCTGTGCCTGGGCAGCATCTACGAGGACCTGAAGATGTATCAGACCGAGTTCCAGGCCATCAATGCCGCCCTGCAGAACCACAATCACCAGCAGATCATCCTGGACAAGGGCATGCTGGTGGCCATCGATGAGCTGATGCAGTCCCTGAACCACAATGGCGAGACCCTGAGGCAGAAGCCTCCAGTGGGAGAGGCCGATCCCTACAGAGTGAAGATGAAGCTGTGCATCCTGCTGCACGCCTTTAGCACAAGGGTGGTGACCATCAACCGCGTGATGGGCTATCTGTCCTCTGCCGGAACAGCAACCCCTGAATCTGGACCTGGAGAGGCAGGCAGGAGCGCCAATCACACCCCAGCCGGGCTGACCGGCCCAGCAACCCCTGAGTCCGGCCCAGGGTCCGAGCCAGCCACCAGCGGCAGCGAAACTCCAGGCACCTCTGAGAGCGCCACTCCTGAGTCCGGGCCAGGATCCCCAGCAGGATCTCCTACAAGCACTGAAGAAGGGTCTCCCGCCGGCAGCCCAACATCTACTGAGGAAGGCACAAGCACTGAACCCTCCGAAGGATCCGCCCCCGGCACATCCGAGTCTGCCACTCCTGAGAGCGGACCCGGCACAAGCGAGTCCGCCACGCCTGAAAGTGGACCAGGCACATCTGCCAGCGCCACTCCAGAAAGCGGCCCTGGAAGCGAACCTGCCACATCCGGCTCCGAGACCCCCGGCTCTGAACCAGCCACAAGCGGCAGCGAAACTCCCGGAAGCCCAGCAGGATCTCCCACAAGCACTGAAGAGGGCACAAGCACGGAGCCTAGCGAAGGATCTGCCCCCGGCACAAGCACTGAACCCAGTGAAGGATCCGCCCCAGGCAGCGAACCAGCCACCTCTGGAAGCGAGACCCCTGGCACCTCCGAGTCTGCCGGAGAGCCTGAGGCCTGA (SEQ ID NO: 848) | ASSATPESGPGTSTEPSEGSAPGTSESATPESGPGSGPATSESATPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPEAGRSANHTPAGLTGPGTSESATPESMWELEKDVYVVEVDWTPDAPGETVNLTCDTPEEDDITWTSDQRHGVIGSGKTLTITVKEFLDAGQYTCHKGGETLSHSHLLLHKKENGIWSTEILKNFKNKTFLKCEAPNYSGRFTCSWLVQRNMDLKFNIKSSSSSPDSRAVTCGMASLSAEKVTLDQRDYEKYSVSCQEDVTCPTAEETLPIELALEARQQNKYENYSTSFFIRDIIKPDPPKNLQMKPLKNSQVEVSWEYPDSWSTPHSYFSLKFFVRIQRKKEKMKETEEGCNQKGAFLVEKTSTEVQCKGGNVCVQAQDRYYNSSCSKWACVPCRVRSGTATPESGPGEAGRSANHTPAGLTGPATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGSPAGSPTSTEEGTSESATPESGPGTSTEPSEGSAPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSPSATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAGASSATPESGPGTSTEPSEGSAPGTSESATPESGPGSGPGTSESATPGTSESATPESGPGSEPATSGSETPGTSESATPESGPGTSTEPSEGSAPGSPAGSPTSTEEGTSESATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSESATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESATPEAGRSANHTPAGLTGPGTSESATPESRVIPVSGPARCLSQSRNLLKTTDDMVKTAREKLKHYSCTAEDIDHEDITRDQTSTLKTCLPLELHKNESCLATRETSSTTRGSCLPPQKTSLMMTLCLGSIYEDLKMYQTEFQAINAALQNHNHQQIILDKGMLVAIDELMQSLNHNGETLRQKPPVGEADPYRVKMKLCILLHAFSTRVVTINRVMGYLSSAGTATPESGPGEAGRSANHTPAGLTGPATPESGPGSEPATSGSETPGTSESATPESGPGSPAGSPTSTEEGSPAGSPTSTEEGTSTEPSEGSAPGTSESATPESGPGTSESATPESGPGTSASATPESGPGSEPATSGSETPGSEPATSGSETPGSPAGSPTSTEEGTSTEPSEGSAPGTSTEPSEGSAPGSEPATSGSETPGTSESAGEPEA (SEQ ID NO: 866) | IL12 |
在攜帶MC38腫瘤之C27/Blk6小鼠模型中監測IL-12-XPAC-4X之毒性。使用此鼠類模型比較測試化合物對muIL12之毒性作用。測試物品在非腫瘤攜帶小鼠(D03、D13、D16及D19)中每3天進行投與。在此模型中在投與之劑量下未看到顯著毒性(如藉由體重減輕所量測)。此等資料展示於圖15B中,其展示在此等非腫瘤攜帶小鼠中,用XPAC處理之小鼠中不存在毒性之跡象,如根據體重變化所量測。然而,在用IL12處理之小鼠中,如藉由體重減輕百分比證明,存在劑量依賴性毒性。
下表展示測試rIL-12及IL-12 XPAC功效之活體內研究設計:
組編號 | 組標識 | 劑量 | 頻率 | 每日莫耳劑量 | 4 天內之莫耳劑量 | 小鼠數目 |
1 | 對照 | 稀釋劑 | 每4天 | 0 | 0 | 8 |
2 | muIL-12 | 30ug | 每日 | 516pmol | 2064pmol | 5 |
3 | muIL-12 | 50ug | 每日 | 860pmol | 3440pmol | 5 |
4 | muIL-12 | 50ug | 每4天 | 860pmol | 860pmol | 5 |
5 | IL-12-XPAC | 300ug | 每4天 | 1720pmol | 1720pmol | 5 |
6 | IL-12-XPAC | 450ug | 每4天 | 2580pmol | 2580pmol | 5 |
圖14展示自上述研究產生之腫瘤消退資料。相比於對照組(第1組)中之小鼠,用IL-12 XPAC(第5組及第6組)處理之小鼠中之腫瘤體積顯著降低。相比較地,用rIL-12(第2組、第3組及第4組)處理之小鼠中幾乎無腫瘤消退。圖15A展示前述組之毒性/體重資料,且展示由於投與測試物品而體重無變化。
實例 12 :包含腫瘤靶向域之 XTEN 化 IL 12 構築體 .
圖13展示本發明之額外例示性實施例,其中XPAC進一步包含腫瘤靶向域。儘管此圖展示一個鏈上之腫瘤靶向域,但應理解,腫瘤靶向域可存在於多於一個鏈上且可存在於其他XTEN鏈中之一者上。腫瘤靶向域之位置應使得其不干擾細胞介素之掩蔽且亦使得其能夠識別靶向腫瘤靶向域之抗原。
在例示性實施例中,腫瘤靶向域亦可經XTEN化。理想地,腫瘤靶向域為表現於腫瘤細胞上但不存在於健康組織中的腫瘤靶向域。舉例而言,在腫瘤中及在慢性發炎病況中,組織重塑及新血管生成過程暴露抗原,否則該等抗原在健康器官中幾乎不可偵測。一個實例係由纖維結合蛋白的剪接變異體表示的,醣蛋白為細胞外基質(ECM)的醣蛋白。纖維結合蛋白之外域A及B(EDA及EDB)在腫瘤中、在組織重塑之部位及在胚胎發育期間強烈表現,但原本在正常組織中未發現,雌性生殖系統除外。類似地,在藉由細胞內pH值調節之方法中,肌腱蛋白-C之剪接變異體尤其發現於經歷新生血管生成之組織及腫瘤中。因此,肌腱蛋白-C之EDA、EDB及剪接變異體代表傳遞生物活性有效負載(如細胞介素)之適合目標。
在致癌惡性腫瘤中,分子標靶可包括纖維母細胞活化蛋白(FAP)、細胞抗原(例如CEA及PSMA)或蛋白質,其在壞死病灶(諸如組蛋白)中變得可接近。在細胞介素融合物之情況下已廣泛表徵之抗體包括F8(靶向EDA-纖維結合蛋白;關於例示性EDA靶向抗體參見美國公開案20210163579)、L19(靶向EDB-纖維結合蛋白;美國公開案20200397915)、F16(靶向肌腱蛋白-C之A1域)、scFv36(靶向FAP)、hu14.18(靶向GD2神經節苷脂)、chCLL -1(靶向CD20)及抗HER2/neu。
簡言之,熟習此項技術者將引用美國公開案20200397915,其提供經設計以靶向纖維結合蛋白EDB之IL-12構築體之詳細描述。美國公開案20210163579顯示靶向纖維結合蛋白之ED-A的例示性構築體。纖維結合蛋白之ED-A已顯示為腫瘤血管生成之標記,且F8抗體已單獨用於腫瘤靶向(WO2008/12001、WO2009/0136619、WO2011/015333)或與TNF或IL2或兩者融合(Villa等人 (2008) Int. J. Cancer 122, 2405-2413;Hemmerle 等人 (2013) Br. J. Cancer 109, 1206-1213;Frey等人 (2008) J. Urol. 184, 2540-2548、WO2010/078945、WO2008/120101、WO2016/180715)與IL4融合 (WO2014/173570)、或與IL12融合(WO2013/014149)。
用於本發明之XPAC之尤佳腫瘤靶向域為US公開案20200397915中所描述之L19抗體或其功能變異體。下表23顯示L19之可變重鏈及輕鏈之序列以及來自彼等鏈之CDR序列。
表 23 :在 XPAC 中用作腫瘤結合域的例示性 L 19 抗體序列
L19 VH | EVQLLESGGGLVQPGGSLRLSCAASGFTFSSFSMSWVRQAPGKGLEWVSS ISGSSGTTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKPF PYFDYWGQGTLVTVSS (SEQ ID NO: 159) |
L19 VL | EIVLTQSPGTLSLSPGERATLSCRASQSVSSSFLAWYQQKPGQAPRLLIY YASSRATGIPDRFSGSGSGTDFTLTISRLEPEDFAVYYCQQTGRIPPTFG QGTKVEIK (SEQ ID NO: 160) |
L19 CDR1 VH | SFSMS (SEQ ID NO: 161) |
L19 CDR2 VH | SISGSSGTTYYADSVKG (SEQ ID NO: 162) |
L19 CDR3 VH | PFPYFDY (SEQ ID NO: 163) |
L19 CDR1 VL | RASQSVSSSFLA (SEQ ID NO: 164) |
L19 CDR2 VL | YASSRAT (SEQ ID NO: 165) |
L19 CDR3 VL | QQTGRIPPT (SEQ ID NO: 166) |
儘管本文已展示及描述本發明之較佳實施例,但熟習此項技術者將明白,此類實施例僅藉助於實例提供。不希望本發明受本說明書中所提供之具體實例的限制。儘管已參考前述說明書描述本發明,但本文實施例之描述及說明並不意欲以限制性意義來解釋。熟習此項技術者可在不背離本發明之情況下想到許多變化形式、改變及取代。此外,應理解,本發明之所有態樣不限於本文所闡述之取決於各種條件及變數之具體描繪、組態或相對比例。應瞭解,本文所描述之本發明實施例的各種替代方案可用於實施本發明。因此,預期本發明亦應涵蓋任何此類替代方案、修改、變化或等效物。希望以下申請專利範圍限定本發明之範圍,且從而涵蓋此申請專利範圍及其等效物之範圍內的方法及結構。
100,101,200,201,205,206:BPXTEN融合蛋白
102,202:XTEN分子
103,203:BP
104,204:間隔子序列
105:BPXTEN融合蛋白,MMP-13蛋白酶
106:BPXTEN融合蛋白,受體
107:細胞
108:核內體
109:信號傳導
500:基因
501,503:寡核苷酸
502:序列模體
504:XTEN基因
506:旗標序列
507:終止序列
508:細胞介素基因
本發明之特徵及優點可參考闡述說明性實施例之以下實施方式及隨附圖式進一步解釋。
圖 1 A- 圖 1 G展示例示性BPXTEN融合蛋白之示意性圖示(圖1A-G),所有均以N端至C端定向描繪。
圖 1 A展示兩種不同組態之BPXTEN融合蛋白(100),其各自包含單一生物活性蛋白(BP)及XTEN,其中之第一者具有連接至BP(103)之C端的XTEN分子(102),且其中之第二者具有連接至BP(103)之N端的XTEN分子。
圖 1 B展示兩種不同組態之BPXTEN融合蛋白(100),其各自包含單一BP、間隔子序列及XTEN,其中之第一者具有連接至間隔子序列(104)之C端的XTEN分子(102)及連接至BP(103)之C端的間隔子序列,且其中之第二者具有連接至間隔子序列(104)之N端的XTEN分子及連接至BP(103)之N端的間隔子序列。
圖 1 C展示兩種不同組態之BPXTEN融合蛋白(101),其各者包含單一BP之兩個分子及XTEN之一個分子,其中之第一者具有連接至第一BP之C端的XTEN且該BP連接至第二BP之C端,且其中之第二者呈相對定向,其中XTEN連接至第一BP之N端且該BP連接至第二BP之N端。
圖 1 D展示兩種不同組態之BPXTEN融合蛋白(101),其各者包含單一BP之兩個分子、間隔子序列及XTEN之一個分子,其中之第一者具有連接至間隔子序列之C端的XTEN及連接至第一BP之C端的間隔子序列且該BP連接至第二BP之C端,且其中之第二者呈相對定向,其中XTEN連接至間隔子序列之N端且間隔子序列連接至第一BP之N端且該BP連接至第二BP之N端。
圖 1 E展示兩種不同組態之BPXTEN融合蛋白(101),其各者包含單一BP之兩個分子、間隔子序列及XTEN之一個分子,其中之第一者具有連接至第一BP之C端的XTEN及連接至間隔子序列之C端的第一BP且該間隔子序列連接至第二BP分子之C端,且其中之第二者呈連接至第一BP(其連接至間隔子序列之N端,該間隔子序列轉而連接至BP之第二分子的N端)之N端的XTEN的相對組態。
圖 1 F展示兩種不同組態之BPXTEN融合蛋白(105),其各者包含單一BP之兩個分子及XTEN之兩個分子,其中之第一者具有連接至第一BP(其連接至第二XTEN之C端)之C端的第一XTEN且該第二XTEN連接至BP之第二分子的C端,且其中之第二者呈連接至第一BP(其連接至第二XTEN之N端,該第二XTEN連接至第二BP之N端)之N端的XTEN的相對組態。
圖 1 G展示在BP之N端及C端處連接至兩個XTEN之單一BP的組態(106)。
圖 2 A- 圖 2 G為編碼
圖 1 A- 圖 1 G之對應BPXTEN多肽之BPXTEN基因的例示性聚核苷酸構築體的示意圖;所有均以5'至3'定向描繪。在此等說明性實例中,基因編碼具有以下之BPXTEN融合蛋白:一個BP及XTEN(100);或兩個BP、一個間隔子序列及一個XTEN(201);兩個BP及兩個XTEN(205);或一個BP及兩個XTEN(206)。在此等繪圖中,聚核苷酸編碼以下組分:XTEN(202)、BP(203)及可包括裂解序列之間隔子胺基酸(204),其中所有序列框內連接。
圖 3 A- 圖 3 E為由內源性可用蛋白酶作用之例示性單體BPXTEN的示意性圖解,以及單體融合蛋白或反應產物結合至細胞表面上之目標受體的能力,以及隨後的細胞信號傳導的示意圖。
圖 3 A展示BPXTEN融合蛋白(101),其中BP(103)及XTEN(102)藉由含有可裂解序列之間隔子序列(104)連接,後者對MMP-13蛋白酶(105)敏感。
圖 3 B展示游離BP、間隔子序列及XTEN之反應產物。
圖 3 C展示游離BP(103)或BPXTEN融合蛋白(101)與目標受體(106)對細胞表面(107)上之BP的相互作用。在此情況下,當BP具有游離C端時展現與受體之所需結合,如游離BP(103)與受體之結合所證明,而未裂解融合蛋白不與受體緊密結合。
圖 3 D展示具有高結合親和力之游離BP(103)保持與受體(106)結合,而完整BPXTEN(101)自受體釋放。
圖 3 E展示結合之BP已內化至細胞(107)內的核內體(108)中,說明受體介導之結合之BP的清除及觸發細胞信號傳導(109),描繪為點狀細胞質。
圖 4為XTEN組裝、產生及評估中之代表性步驟的示意性流程圖。
圖 5為編碼融合蛋白之BP-XTEN聚核苷酸構築體之組裝中代表性步驟的示意性流程圖。將個別寡核苷酸
501黏接成序列模體
502,諸如12個胺基酸模體(「12聚體」),其隨後與含有BbsI及KpnI限制性位點之寡核苷酸
503接合。使來自庫之額外序列模體黏接成12聚體,直至達成XTEN基因
504之所需長度。將XTEN基因選殖至填充(stuffer)載體中。載體編碼旗標序列
506,隨後為由BsaI、BbsI及KpnI位點側接之終止序列
507及細胞介素基因
508,產生編碼用於併入至BPXTEN組合中之BP-XTEN融合物的基因
500。
圖 6為編碼融合蛋白之基因之組裝中代表性步驟的示意性流程圖,該融合蛋白包含生物活性蛋白(BP)及XTEN,其作為融合蛋白之表現及回收,以及其作為候選BPXTEN產物之評估。
圖 7示出具有胺基酸序列SEQ ID NO: 2(參見
表 B)之例示性XTEN化細胞介素(亦即「
XTEN 化 IL 12」構築體)的結構組態。例示性「
XTEN 化 IL 12」構築體包含能夠由哺乳動物蛋白酶裂解之裂解序列。在例示性「
XTEN 化 IL 12」構築體之蛋白酶裂解後,釋放相應的「
去 XTEN 化 IL 12」片段及「
XTEN 片段」。亦示出含有相同IL12部分之參考細胞介素構築體(亦即
參考 IL 12」構築體),其具有胺基酸序列SEQ ID NO: 4(參見
表 B)。
圖 8示出由於XTEN化而降低的細胞介素活性。舉例而言,相對於相應蛋白質活化、去XTEN化(未掩蔽)IL-12組合物,XTEN化(掩蔽)介白素-12(IL12)組合物(SEQ ID NO: 2)在293 HEK IL-12報導細胞中誘導信號轉導及轉錄活化子4(STAT-4)的活性至少低2倍。對XTEN化細胞介素組合物進行去XTEN化的蛋白酶處理於
圖 7中示出。XTEN化IL12之EC50(具有167.0之值)大於相應去XTEN化IL12之EC50(具有79.4之值),指示XTEN對IL12蛋白質且更一般而言對細胞介素之掩蔽能力。
圖 9 A- 圖 9 B示出細胞介素結合中之XTEN化介導的減少。舉例而言,
圖 9 A示出「XTEN化IL12」組合物(SEQ ID NO: 2)及無XTEN化之「參考IL12」組合物(SEQ ID NO: 4)與293 HEK-IL12報導細胞(HEK- Blue
TMIL-12細胞(Invivogen, San Diego, CA))之結合。「
XTEN 化 IL 12」之EC50(具有約11.8之值)大於「
參考 IL 12」之EC50(具有約4.5之值),指示XTEN干擾IL12與相應IL12受體之間的結合的能力(亦即掩蔽效應)。
圖 9 B示出「XTEN化IL12」及「參考IL12」組合物與IL12受體陰性293 HEK細胞(對照)之間缺乏結合。作為另一對照,未觀測到相應XTEN片段(參見
圖 7)與IL12報導細胞或IL12陰性對照細胞之結合。
圖 10 A- 圖 10 C 。IL12-XPAC-4X結構及活性分析。
圖 10 A展示例示性IL12-XPAC-4X之示意性結構,其中IL-12次單元上存在4個XTEN鏈。
圖 10 B展示圖10A中所示之IL12-XPAC-4X的示意圖,其中添加轉麩醯胺酸酶標籤(TG)標籤。TG標籤由箭頭展示。
圖 10 C展示來自
圖 10 A及
圖 10 B中兩個構築體的PAC及XPAC的HEK Blue活性分析。
圖 11 A- 圖 11 C 。所有XTEN掩蔽活性。
圖 11 A展示含有四個XTEN部分(AP2446)之例示性構築體的活性。
圖 11 B展示含有三個XTEN部分(AP2447)之例示性構築體的活性。
圖 11 C展示含有一個XTEN部分(AP2450)之例示性構築體的活性。
圖 12 A- 圖 12 C 。三個例示性IL12-XPAC-4X構築體之設計。
圖 12 A為AC2582/AC2585之設計,
圖 12 B為AC3244/AC3247之設計。
圖 12 C為AC3245/AC3246之設計。
圖 13展示進一步包含腫瘤結合域之例示性XPAC之示意圖。
圖 14展示來自在攜帶MC38腫瘤之C57/Blk6小鼠中進行之活體內功效研究的腫瘤消退結果。一旦確立,腫瘤用稀釋劑、三種不同濃度之rIL-12或兩種不同濃度之IL-12-XPAC治療。所展示資料支持IL-12 XPAC在產生腫瘤消退方面之功效。
圖 15 A展示自圖14中所示之攜帶腫瘤之小鼠研究獲得之毒性/體重資料。
圖 15 B展示rIL12及IL12 XPAC對非腫瘤攜帶小鼠之體重的影響。此等資料表明XPAC安全性。
<![CDATA[<110> 美商亞穆尼克斯製藥公司(Amunix Pharmaceuticals Inc.)]]> <![CDATA[<120> 細胞介素結合物]]> <![CDATA[<130> 20-1836-WO]]> <![CDATA[<150> 63/197,875]]> <![CDATA[<151> 2021-06-07]]> <![CDATA[<150> 63/197,944]]> <![CDATA[<151> 2021-06-07]]> <![CDATA[<160> 909 ]]> <![CDATA[<170> PatentIn version 3.5]]> <![CDATA[<210> 1]]> <![CDATA[<211> 4216]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> misc_feature]]> <![CDATA[<222> (2623)..(2623)]]> <![CDATA[<223> n為任何核苷酸]]> <![CDATA[<400> 1]]> gcatcacatc atcaccatca ccatcaccat ggttctccag ccgggtcccc aacttcgacc 60 gaggaaggga cctccgagtc agctaccccg gagtccggtc ctggcacctc caccgaacca 120 tcggagggca gcgcccctgg gagccctgcc gggagcccta caagcaccga agagggcacc 180 agtacagagc caagtgaggg gagcgcccct ggtactagta ctgaaccatc cgaggggtca 240 gctccaggca cgagtgagtc cgctaccccc gagagcggac cgggctcaga gcccgccacg 300 agtggcagtg aaactccagg ctcagaaccc gccactagtg ggtcagagac tccaggcagc 360 cctgccggat cccctacgtc caccgaggag ggaacatctg agtccgcaac acccgaatcc 420 ggtccaggca cctccacgga acctagtgaa ggctcggcac caggtacaag caccgaacct 480 agcgagggca gcgctcccgg cagccctgcc ggcagcccaa cctcaactga ggagggcacc 540 agtactgagc ccagcgaggg atcagcacct ggcaccagca ccgaacctag cgaggggagc 600 gcccctggga ctagcgagtc agctacacca gagagcgggc ctggaacttc taccgaaccc 660 agtgagggat ccgctccagg cacctccgaa tccgcaaccc ccgaatccgg acctggctca 720 gagcccgcca ccagcgggag cgaaacccct ggcacatcca ccgagcctag cgaagggtcc 780 gcacccggca ccagtacaga gcctagcgag ggatcagcac ctggcaccag tgaatctgct 840 acaccagaga gcggccctgg aacctccgag tccgctaccc ccgagagcgg gccaggttct 900 cctgctggct cccccacctc aacagaagag gggacaagcg aaagcgctac gcctgagagt 960 ggccctggct ctgagccagc cacctccggc tctgaaaccc ctggcactag tgagtctgcc 1020 acgcctgagt ccggacccgg gacctctact gagccctcgg aggggagcgc tcctggcacg 1080 agtacagaac cttccgaagg aagtgcaccg ggcacaagca ccgagccttc cgaaggctct 1140 gctcccggaa cctctaccga accctctgaa gggtctgcac ccggcacgag caccgaaccc 1200 agcgaagggt cagcgcctgg gacctcaaca gagccctcgg aaggatcagc gcctggaagc 1260 cctgcaggga gtccaacttc cacggaagaa ggaacgtcta cagagccatc agaggggtcc 1320 gcaccaggta ccagcgaatc cgctactccc gaatctggcc ctgggtccga acctgccacc 1380 tccggctctg aaactccagg gacctccgaa tctgccacac ccgagagcgg ccctggctcc 1440 gagcccgcaa catctggcag cgagacacct ggcacctccg agagcgcaac acccgagagc 1500 ggccctggca ccagcaccga gccatccgag ggatccgccc caggcacttc tgagtcagcc 1560 acacccgaaa gcggaccagg atcacccgct ggctccccca ccagtaccga ggaggggtcc 1620 cccgctggaa gtccaacaag cactgaggaa gggtcccctg ccggctcccc cacaagtacc 1680 gaagagggca caagtgagag cgccactccc gagtccgggc ctggcaccag cacagagcct 1740 tccgaggggt ccgcaccagg tacctcagag tctgctaccc ccgagtcagg gccaggatca 1800 gagccagcca cctccgggtc tgagacaccc gggacttccg agagtgccac ccctgagtcc 1860 ggacccgggt ccgagcccgc cacttccggc tccgaaactc ccggcacaag cgagagcgct 1920 accccagagt caggaccagg aacatctaca gagccctctg aaggctccgc tccagggtcc 1980 ccagccggca gtcccactag caccgaggag ggaacctctg aaagcgccac acccgaatca 2040 gggccagggt ctgagcctgc taccagcggc agcgagacac caggcacctc tgagtccgcc 2100 acaccagagt ccggacccgg atctcccgct gggagcccca cctccactga ggagggatct 2160 cctgctggct ctccaacatc tactgaggaa ggtacctcaa ccgagccatc cgagggatca 2220 gctcccggca cctcagagtc ggcaaccccg gagtctggac ccggaacttc cgaaagtgcc 2280 acaccagagt ccggtcccgg gacttcagaa tcagcaacac ccgagtccgg ccctgggtct 2340 gaacccgcca caagtggtag tgagacacca ggatcagaac ctgctacctc agggtcagag 2400 acacccggat ctccggcagg ctcaccaacc tccactgagg agggcaccag cacagaacca 2460 agcgagggct ccgcacccgg aacaagcact gaacccagtg agggttcagc acccggctct 2520 gagccggcca caagtggcag tgagacaccc ggcacttcag agagtgccac ccccgagagt 2580 ggcccaggca ctagtaccga gccctctgaa ggcagtgcgc canggcacag ccgaggccgc 2640 tagcgccagc ggcatgtggg agctggagaa ggacgtgtac gtggtggagg tggactggac 2700 accagatgcc cccggcgaga ccgtgaacct gacatgcgac acccccgagg aggacgatat 2760 cacctggaca tctgatcaga ggcacggcgt gatcggaagc ggcaagaccc tgacaatcac 2820 cgtgaaggag ttcctggatg ccggccagta cacatgtcac aagggcggcg agaccctgtc 2880 ccactctcac ctgctgctgc acaagaagga gaacggcatc tggtccacag agatcctgaa 2940 gaacttcaag aataagacct ttctgaagtg cgaggcccct aattatagcg gccggttcac 3000 ctgttcctgg ctggtgcaga gaaacatgga cctgaagttt aatatcaaga gctcctctag 3060 ctccccagat agccgggcag tgacatgcgg aatggccagc ctgtccgccg agaaggtgac 3120 cctggaccag agagattacg agaagtattc tgtgagctgc caggaggacg tgacatgtcc 3180 caccgccgag gagacactgc ctatcgagct ggccctggag gccaggcagc agaacaagta 3240 cgagaattat tccacctctt tctttatccg cgacatcatc aagccagatc cccctaagaa 3300 cctgcagatg aagcccctga agaattccca ggtcgaggtg tcttgggagt accctgacag 3360 ctggtccaca ccacactctt atttcagcct gaagttcttt gtgaggatcc agcgcaagaa 3420 ggagaagatg aaggagaccg aggagggctg caatcagaag ggcgcctttc tggtggagaa 3480 gacatccacc gaggtgcagt gcaagggagg aaacgtgtgc gtgcaggcac aggatcggta 3540 ctataattct agctgttcca agtgggcctg cgtgccttgt cgggtgagat ctggcggcgg 3600 cggctctggc ggcggcggct ccggcggcgg cggctccaga gtgatccccg tgagcggacc 3660 agcaaggtgc ctgtcccaga gccggaacct gctgaagacc acagacgata tggtgaagac 3720 cgcccgggag aagctgaagc actactcttg tacagccgag gacatcgatc acgaggacat 3780 cacccgggat cagacctcta cactgaagac atgcctgccc ctggagctgc acaagaacga 3840 gagctgtctg gccacccggg agacaagctc caccacaaga ggcagctgcc tgccccctca 3900 gaagacctcc ctgatgatga ccctgtgcct gggctctatc tacgaggacc tgaagatgta 3960 tcagaccgag ttccaggcca tcaatgccgc cctgcagaac cacaatcacc agcagatcat 4020 cctggacaag ggcatgctgg tggccatcga tgagctgatg cagagcctga accacaatgg 4080 cgagaccctg aggcagaagc caccagtggg agaggcagat ccttacaggg tgaagatgaa 4140 gctgtgcatc ctgctgcacg ccttttccac cagggtggtg acaatcaatc gcgtgatggg 4200 ctatctgtct agcgcc 4216 <![CDATA[<210> 2]]> <![CDATA[<211> 1406]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (875)..(875)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 2]]> Ala Ser His His His His His His His His Gly Ser Pro Ala Gly Ser 1 5 10 15 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 20 25 30 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 35 40 45 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 50 55 60 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 65 70 75 80 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 85 90 95 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr 100 105 110 Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 115 120 125 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 130 135 140 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 145 150 155 160 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 165 170 175 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 180 185 190 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 195 200 205 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 210 215 220 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 225 230 235 240 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro 245 250 255 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 260 265 270 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 275 280 285 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 290 295 300 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 305 310 315 320 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 325 330 335 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 340 345 350 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 355 360 365 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 370 375 380 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 385 390 395 400 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 405 410 415 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 420 425 430 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 435 440 445 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 450 455 460 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 465 470 475 480 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 485 490 495 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 500 505 510 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 515 520 525 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 530 535 540 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 545 550 555 560 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 565 570 575 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 580 585 590 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 595 600 605 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 610 615 620 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 625 630 635 640 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 645 650 655 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 660 665 670 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 675 680 685 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 690 695 700 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 705 710 715 720 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 725 730 735 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 740 745 750 Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 755 760 765 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 770 775 780 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 785 790 795 800 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 805 810 815 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 820 825 830 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 835 840 845 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 850 855 860 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Xaa Gly Thr Ala Glu Ala 865 870 875 880 Ala Ser Ala Ser Gly Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val 885 890 895 Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr 900 905 910 Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg 915 920 925 His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu 930 935 940 Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu 945 950 955 960 Ser His Ser His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser 965 970 975 Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu 980 985 990 Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg 995 1000 1005 Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro 1010 1015 1020 Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu 1025 1030 1035 Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser 1040 1045 1050 Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu Pro 1055 1060 1065 Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn 1070 1075 1080 Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro 1085 1090 1095 Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu 1100 1105 1110 Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr 1115 1120 1125 Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys 1130 1135 1140 Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu 1145 1150 1155 Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 1160 1165 1170 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys 1175 1180 1185 Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser 1190 1195 1200 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val 1205 1210 1215 Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys 1220 1225 1230 Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His 1235 1240 1245 Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg 1250 1255 1260 Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His 1265 1270 1275 Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 1280 1285 1290 Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr 1295 1300 1305 Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr 1310 1315 1320 Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln 1325 1330 1335 Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu 1340 1345 1350 Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro 1355 1360 1365 Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys 1370 1375 1380 Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg 1385 1390 1395 Val Met Gly Tyr Leu Ser Ser Ala 1400 1405 <![CDATA[<210> 3]]> <![CDATA[<211> 1587]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 3]]> atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg actggacacc agatgccccc 60 ggcgagaccg tgaacctgac atgcgacacc cccgaggagg acgatatcac ctggacatct 120 gatcagaggc acggcgtgat cggaagcggc aagaccctga caatcaccgt gaaggagttc 180 ctggatgccg gccagtacac atgtcacaag ggcggcgaga ccctgtccca ctctcacctg 240 ctgctgcaca agaaggagaa cggcatctgg tccacagaga tcctgaagaa cttcaagaat 300 aagacctttc tgaagtgcga ggcccctaat tatagcggcc ggttcacctg ttcctggctg 360 gtgcagagaa acatggacct gaagtttaat atcaagagct cctctagctc cccagatagc 420 cgggcagtga catgcggaat ggccagcctg tccgccgaga aggtgaccct ggaccagaga 480 gattacgaga agtattctgt gagctgccag gaggacgtga catgtcccac cgccgaggag 540 acactgccta tcgagctggc cctggaggcc aggcagcaga acaagtacga gaattattcc 600 acctctttct ttatccgcga catcatcaag ccagatcccc ctaagaacct gcagatgaag 660 cccctgaaga attcccaggt cgaggtgtct tgggagtacc ctgacagctg gtccacacca 720 cactcttatt tcagcctgaa gttctttgtg aggatccagc gcaagaagga gaagatgaag 780 gagaccgagg agggctgcaa tcagaagggc gcctttctgg tggagaagac atccaccgag 840 gtgcagtgca agggaggaaa cgtgtgcgtg caggcacagg atcggtacta taattctagc 900 tgttccaagt gggcctgcgt gccttgtcgg gtgagatctg gcggcggcgg ctctggcggc 960 ggcggctccg gcggcggcgg ctccagagtg atccccgtga gcggaccagc aaggtgcctg 1020 tcccagagcc ggaacctgct gaagaccaca gacgatatgg tgaagaccgc ccgggagaag 1080 ctgaagcact actcttgtac agccgaggac atcgatcacg aggacatcac ccgggatcag 1140 acctctacac tgaagacatg cctgcccctg gagctgcaca agaacgagag ctgtctggcc 1200 acccgggaga caagctccac cacaagaggc agctgcctgc cccctcagaa gacctccctg 1260 atgatgaccc tgtgcctggg ctctatctac gaggacctga agatgtatca gaccgagttc 1320 caggccatca atgccgccct gcagaaccac aatcaccagc agatcatcct ggacaagggc 1380 atgctggtgg ccatcgatga gctgatgcag agcctgaacc acaatggcga gaccctgagg 1440 cagaagccac cagtgggaga ggcagatcct tacagggtga agatgaagct gtgcatcctg 1500 ctgcacgcct tttccaccag ggtggtgaca atcaatcgcg tgatgggcta tctgtctagc 1560 gcccatcatc accatcacca tcaccat 1587 <![CDATA[<210> 4]]> <![CDATA[<211> 529]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 4]]> Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 1 5 10 15 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 20 25 30 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 35 40 45 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 50 55 60 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 65 70 75 80 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 85 90 95 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 100 105 110 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 115 120 125 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 130 135 140 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 145 150 155 160 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 165 170 175 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 180 185 190 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 195 200 205 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 210 215 220 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 225 230 235 240 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 245 250 255 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 260 265 270 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 275 280 285 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 290 295 300 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 325 330 335 Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 340 345 350 Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 355 360 365 Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 370 375 380 Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 385 390 395 400 Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 405 410 415 Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 420 425 430 Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 435 440 445 Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 450 455 460 Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 465 470 475 480 Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 485 490 495 Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 500 505 510 Arg Val Met Gly Tyr Leu Ser Ser Ala His His His His His His His 515 520 525 His <![CDATA[<210> 5]]> <![CDATA[<211> 313]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 5]]> Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 1 5 10 15 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 20 25 30 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 35 40 45 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 50 55 60 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 65 70 75 80 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 85 90 95 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 100 105 110 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 115 120 125 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 130 135 140 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 145 150 155 160 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 165 170 175 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 180 185 190 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 195 200 205 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 210 215 220 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 225 230 235 240 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 245 250 255 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 260 265 270 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 275 280 285 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 290 295 300 Ala Cys Val Pro Cys Arg Val Arg Ser 305 310 <![CDATA[<210> 6]]> <![CDATA[<211> 193]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 6]]> Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 1 5 10 15 Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 20 25 30 Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 35 40 45 Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 50 55 60 His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 65 70 75 80 Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 85 90 95 Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 100 105 110 Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 115 120 125 Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 130 135 140 Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 145 150 155 160 Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 165 170 175 Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 180 185 190 Ala <![CDATA[<210> 7]]> <![CDATA[<211> 521]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 7]]> Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 1 5 10 15 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 20 25 30 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 35 40 45 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 50 55 60 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 65 70 75 80 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 85 90 95 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 100 105 110 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 115 120 125 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 130 135 140 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 145 150 155 160 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 165 170 175 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 180 185 190 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 195 200 205 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 210 215 220 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 225 230 235 240 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 245 250 255 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 260 265 270 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 275 280 285 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 290 295 300 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Gly Gly Gly Ser Gly Gly 305 310 315 320 Gly Gly Ser Gly Gly Gly Gly Ser Arg Val Ile Pro Val Ser Gly Pro 325 330 335 Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 340 345 350 Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 355 360 365 Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 370 375 380 Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 385 390 395 400 Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 405 410 415 Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 420 425 430 Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 435 440 445 Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 450 455 460 Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 465 470 475 480 Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 485 490 495 Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 500 505 510 Arg Val Met Gly Tyr Leu Ser Ser Ala 515 520 <![CDATA[<210> 8]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 8]]> Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 <![CDATA[<210> 9]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 9]]> Arg Arg Gln Arg Arg Thr Ser Lys Leu Met Lys Arg 1 5 10 <![CDATA[<210> 10]]> <![CDATA[<211> 27]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 10]]> Gly Trp Thr Leu Asn Ser Ala Gly Tyr Leu Leu Gly Lys Ile Asn Leu 1 5 10 15 Lys Ala Leu Ala Ala Leu Ala Lys Lys Ile Leu 20 25 <![CDATA[<210> 11]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 11]]> Lys Ala Leu Ala Trp Glu Ala Lys Leu Ala Lys Ala Leu Ala Lys Ala 1 5 10 15 Leu Ala Lys His Leu Ala Lys Ala Leu Ala Lys Ala Leu Lys Cys Glu 20 25 30 Ala <![CDATA[<210> 12]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 12]]> Arg Gln Ile Lys Ile Trp Phe Gln Asn Arg Arg Met Lys Trp Lys Lys 1 5 10 15 <![CDATA[<210> 13]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 13]]> Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 <![CDATA[<210> 14]]> <![CDATA[<211> 9]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 14]]> Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 <![CDATA[<210> 15]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 15]]> Tyr Gly Arg Lys Lys Arg Arg Gln Arg Arg Arg 1 5 10 <![CDATA[<210> 16]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 16]]> Arg Lys Lys Arg Arg Gln Arg Arg 1 5 <![CDATA[<210> 17]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 17]]> Tyr Ala Arg Ala Ala Ala Arg Gln Ala Arg Ala 1 5 10 <![CDATA[<210> 18]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 18]]> Thr His Arg Leu Pro Arg Arg Arg Arg Arg Arg 1 5 10 <![CDATA[<210> 19]]> <![CDATA[<211> 11]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 19]]> Gly Gly Arg Arg Ala Arg Arg Arg Arg Arg Arg 1 5 10 <![CDATA[<210> 20]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 20]]> Leu Ala Gly Arg Ser Asp Asn His Ser Pro Leu Gly Leu Ala Gly Ser 1 5 10 15 <![CDATA[<210> 21]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 21]]> Leu Ala Gly Arg Ser Asp Asn His Val Pro Leu Ser Leu Ser Met Gly 1 5 10 15 <![CDATA[<210> 22]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 22]]> Leu Ala Gly Arg Ser Asp Asn His Glu Pro Leu Glu Leu Val Ala Gly 1 5 10 15 <![CDATA[<210> 23]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 23]]> Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Ser Gly Leu Ala Gly Pro 1 5 10 15 <![CDATA[<210> 24]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 24]]> Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Gln Gly Leu Ala Gly Gln 1 5 10 15 <![CDATA[<210> 25]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 25]]> Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 26]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 26]]> Ala Ser Ser Arg Gly Thr Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 27]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 27]]> Ala Ser Ser Arg Thr Thr Asn Thr Gly Pro Ser Thr Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 28]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 28]]> Ala Ala Gly Arg Ser Asp Asn Gly Thr Pro Leu Glu Leu Val Ala Pro 1 5 10 15 <![CDATA[<210> 29]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 29]]> Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly Leu Val Ala Thr 1 5 10 15 <![CDATA[<210> 30]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 30]]> Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 31]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 31]]> Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu Leu Gly Gly Gly 1 5 10 15 <![CDATA[<210> 32]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 32]]> Thr Ala Gly Arg Ser Asp Asn Leu Glu Pro Leu Gly Leu Val Phe Gly 1 5 10 15 <![CDATA[<210> 33]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 33]]> Leu Asp Gly Arg Ser Asp Asn Phe His Pro Pro Glu Leu Val Ala Gly 1 5 10 15 <![CDATA[<210> 34]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 34]]> Leu Glu Gly Arg Ser Asp Asn Glu Glu Pro Glu Asn Leu Val Ala Gly 1 5 10 15 <![CDATA[<210> 35]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 35]]> Leu Lys Gly Arg Ser Asp Asn Asn Ala Pro Leu Ala Leu Val Ala Gly 1 5 10 15 <![CDATA[<210> 36]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 36]]> Val Tyr Ser Arg Gly Thr Asn Ala Gly Pro His Gly Leu Thr Gly Arg 1 5 10 15 <![CDATA[<210> 37]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 37]]> Ala Asn Ser Arg Gly Thr Asn Lys Gly Phe Ala Gly Leu Ile Gly Pro 1 5 10 15 <![CDATA[<210> 38]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 38]]> Ala Ser Ser Arg Leu Thr Asn Glu Ala Pro Ala Gly Leu Thr Ile Pro 1 5 10 15 <![CDATA[<210> 39]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 39]]> Asp Gln Ser Arg Gly Thr Asn Ala Gly Pro Glu Gly Leu Thr Asp Pro 1 5 10 15 <![CDATA[<210> 40]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 40]]> Glu Ser Ser Arg Gly Thr Asn Ile Gly Gln Gly Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 41]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 41]]> Ser Ser Ser Arg Gly Thr Asn Gln Asp Pro Ala Gly Leu Thr Ile Pro 1 5 10 15 <![CDATA[<210> 42]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 42]]> Ala Ser Ser Arg Gly Gln Asn His Ser Pro Met Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 43]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 43]]> Ala Tyr Ser Arg Gly Pro Asn Ala Gly Pro Ala Gly Leu Glu Gly Arg 1 5 10 15 <![CDATA[<210> 44]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 44]]> Ala Ser Glu Arg Gly Asn Asn Ala Gly Pro Ala Asn Leu Thr Gly Phe 1 5 10 15 <![CDATA[<210> 45]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 45]]> Ala Ser His Arg Gly Thr Asn Pro Lys Pro Ala Ile Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 46]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 46]]> Met Ser Ser Arg Arg Thr Asn Ala Asn Pro Ala Gln Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 47]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 47]]> Gly Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu Leu Gly Ala Ala 1 5 10 15 <![CDATA[<210> 48]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 48]]> Leu Ala Gly Arg Ser Glu Asn Thr Ala Pro Leu Glu Leu Thr Ala Gly 1 5 10 15 <![CDATA[<210> 49]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 49]]> Leu Glu Gly Arg Pro Asp Asn His Glu Pro Leu Ala Leu Val Ala Ser 1 5 10 15 <![CDATA[<210> 50]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 50]]> Leu Ser Gly Arg Ser Asp Asn Glu Glu Pro Leu Ala Leu Pro Ala Gly 1 5 10 15 <![CDATA[<210> 51]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 51]]> Glu Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu Leu Ser Ala Pro 1 5 10 15 <![CDATA[<210> 52]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 52]]> Glu Gly Gly Arg Ser Asp Asn His Gly Pro Leu Glu Leu Val Ser Gly 1 5 10 15 <![CDATA[<210> 53]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 53]]> Leu Ser Gly Arg Ser Asp Asn Glu Ala Pro Leu Glu Leu Glu Ala Gly 1 5 10 15 <![CDATA[<210> 54]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 54]]> Leu Gly Gly Arg Ala Asp Asn His Glu Pro Pro Glu Leu Gly Ala Gly 1 5 10 15 <![CDATA[<210> 55]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 55]]> Pro Pro Ser Arg Gly Thr Asn Ala Glu Pro Ala Gly Leu Thr Gly Glu 1 5 10 15 <![CDATA[<210> 56]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 56]]> Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro Ala Gly Leu Glu Ala Pro 1 5 10 15 <![CDATA[<210> 57]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 57]]> Glu Ser Ser Arg Gly Thr Asn Gly Ala Pro Glu Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 58]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 58]]> Ala Ser Ser Arg Ala Thr Asn Glu Ser Pro Ala Gly Leu Thr Gly Glu 1 5 10 15 <![CDATA[<210> 59]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 59]]> Ala Ser Ser Arg Gly Glu Asn Pro Pro Pro Gly Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 60]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 60]]> Ala Ala Ser Arg Gly Thr Asn Thr Gly Pro Ala Glu Leu Thr Gly Ser 1 5 10 15 <![CDATA[<210> 61]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 61]]> Ala Gly Ser Arg Thr Thr Asn Ala Gly Pro Gly Gly Leu Glu Gly Pro 1 5 10 15 <![CDATA[<210> 62]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 62]]> Ala Pro Ser Arg Gly Glu Asn Ala Gly Pro Ala Thr Leu Thr Gly Ala 1 5 10 15 <![CDATA[<210> 63]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 63]]> Glu Ser Gly Arg Ala Ala Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro 1 5 10 15 <![CDATA[<210> 64]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 64]]> Asn Pro Gly Arg Ala Ala Asn Glu Gly Pro Pro Gly Leu Pro Gly Ser 1 5 10 15 <![CDATA[<210> 65]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 65]]> Glu Ser Ser Arg Ala Ala Asn Leu Thr Pro Pro Glu Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 66]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 66]]> Ala Ser Gly Arg Ala Ala Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala 1 5 10 15 <![CDATA[<210> 67]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 67]]> Asn Ser Gly Arg Gly Glu Asn Leu Gly Ala Pro Gly Leu Thr Gly Thr 1 5 10 15 <![CDATA[<210> 68]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 68]]> Thr Thr Gly Arg Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 69]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 69]]> Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 70]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 70]]> Glu Ser Gly Arg Ala Ala Asn Thr Thr Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 71]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 71]]> Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 72]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 72]]> Thr Thr Gly Arg Ala Glu Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 73]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 73]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 74]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 74]]> Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 75]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 75]]> Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala 1 5 10 15 Thr Gly Pro <![CDATA[<210> 76]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 76]]> Thr Thr Gly Glu Ala Gly Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala 1 5 10 15 Thr Gly Pro <![CDATA[<210> 77]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 77]]> Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 78]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 78]]> Thr Thr Gly Ala Ala Gly Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 79]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 79]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 80]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 80]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala 1 5 10 15 Thr Gly Pro <![CDATA[<210> 81]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 81]]> Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Ala Thr Ser Ala Gly Ala 1 5 10 15 Thr Gly Pro <![CDATA[<210> 82]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 82]]> Glu Ser Gly Arg Ala Ala Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly 1 5 10 15 <![CDATA[<210> 83]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 83]]> Glu Ser Gly Arg Ala Ala Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro 1 5 10 15 <![CDATA[<210> 84]]> <![CDATA[<211> 16]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 84]]> Glu Pro Gly Arg Ala Ala Asn His Glu Pro Ser Gly Leu Thr Glu Gly 1 5 10 15 <![CDATA[<210> 85]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 85]]> Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Pro Pro Gly Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 86]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 86]]> Thr Thr Gly Arg Thr Gly Glu Gly Ala Asn Ala Thr Pro Gly Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 87]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 87]]> Arg Thr Gly Arg Ser Gly Glu Ala Ala Asn Glu Thr Pro Glu Gly Leu 1 5 10 15 Glu Gly Pro <![CDATA[<210> 88]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 88]]> Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn Glu Thr Pro Ala Gly Leu 1 5 10 15 Gly Gly Pro <![CDATA[<210> 89]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 89]]> Ser Thr Gly Arg Thr Gly Glu Pro Ala Asn Glu Thr Pro Ala Gly Leu 1 5 10 15 Ser Gly Pro <![CDATA[<210> 90]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 90]]> Thr Thr Gly Arg Ala Gly Glu Pro Ala Asn Ala Thr Pro Thr Gly Leu 1 5 10 15 Ser Gly Pro <![CDATA[<210> 91]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 91]]> Arg Thr Gly Arg Pro Gly Glu Gly Ala Asn Ala Thr Pro Thr Gly Leu 1 5 10 15 Pro Gly Pro <![CDATA[<210> 92]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 92]]> Arg Thr Gly Arg Gly Gly Glu Ala Ala Asn Ala Thr Pro Ser Gly Leu 1 5 10 15 Gly Gly Pro <![CDATA[<210> 93]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 93]]> Ser Thr Gly Arg Ser Gly Glu Ser Ala Asn Ala Thr Pro Gly Gly Leu 1 5 10 15 Gly Gly Pro <![CDATA[<210> 94]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 94]]> Arg Thr Gly Arg Thr Gly Glu Glu Ala Asn Ala Thr Pro Ala Gly Leu 1 5 10 15 Pro Gly Pro <![CDATA[<210> 95]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 95]]> Ala Thr Gly Arg Pro Gly Glu Pro Ala Asn Thr Thr Pro Glu Gly Leu 1 5 10 15 Glu Gly Pro <![CDATA[<210> 96]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 96]]> Ser Thr Gly Arg Ser Gly Glu Pro Ala Asn Ala Thr Pro Gly Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 97]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 97]]> Pro Thr Gly Arg Gly Gly Glu Gly Ala Asn Thr Thr Pro Thr Gly Leu 1 5 10 15 Pro Gly Pro <![CDATA[<210> 98]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 98]]> Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 99]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 99]]> Thr Thr Gly Arg Ala Ser Glu Gly Ala Asn Ser Thr Pro Ala Pro Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 100]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 100]]> Thr Tyr Gly Arg Ala Ala Glu Ala Ala Asn Thr Thr Pro Ala Gly Leu 1 5 10 15 Thr Ala Pro <![CDATA[<210> 101]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 101]]> Thr Thr Gly Arg Ala Thr Glu Gly Ala Asn Ala Thr Pro Ala Glu Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 102]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 102]]> Thr Val Gly Arg Ala Ser Glu Glu Ala Asn Thr Thr Pro Ala Ser Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 103]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 103]]> Thr Thr Gly Arg Ala Pro Glu Ala Ala Asn Ala Thr Pro Ala Pro Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 104]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 104]]> Thr Trp Gly Arg Ala Thr Glu Pro Ala Asn Ala Thr Pro Ala Pro Leu 1 5 10 15 Thr Ser Pro <![CDATA[<210> 105]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 105]]> Thr Val Gly Arg Ala Ser Glu Ser Ala Asn Ala Thr Pro Ala Glu Leu 1 5 10 15 Thr Ser Pro <![CDATA[<210> 106]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 106]]> Thr Val Gly Arg Ala Pro Glu Gly Ala Asn Ser Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 107]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 107]]> Thr Trp Gly Arg Ala Thr Glu Ala Pro Asn Leu Glu Pro Ala Thr Leu 1 5 10 15 Thr Thr Pro <![CDATA[<210> 108]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 108]]> Thr Thr Gly Arg Ala Thr Glu Ala Pro Asn Leu Thr Pro Ala Pro Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 109]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 109]]> Thr Gln Gly Arg Ala Thr Glu Ala Pro Asn Leu Ser Pro Ala Ala Leu 1 5 10 15 Thr Ser Pro <![CDATA[<210> 110]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 110]]> Thr Gln Gly Arg Ala Ala Glu Ala Pro Asn Leu Thr Pro Ala Thr Leu 1 5 10 15 Thr Ala Pro <![CDATA[<210> 111]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 111]]> Thr Ser Gly Arg Ala Pro Glu Ala Thr Asn Leu Ala Pro Ala Pro Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 112]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 112]]> Thr Gln Gly Arg Ala Ala Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 113]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 113]]> Thr Thr Gly Arg Ala Gly Ser Ala Pro Asn Leu Pro Pro Thr Gly Leu 1 5 10 15 Thr Thr Pro <![CDATA[<210> 114]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 114]]> Thr Thr Gly Arg Ala Gly Gly Ala Glu Asn Leu Pro Pro Glu Gly Leu 1 5 10 15 Thr Ala Pro <![CDATA[<210> 115]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 115]]> Thr Thr Ser Arg Ala Gly Thr Ala Thr Asn Leu Thr Pro Glu Gly Leu 1 5 10 15 Thr Ala Pro <![CDATA[<210> 116]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 116]]> Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro Pro Ser Gly Leu 1 5 10 15 Thr Thr Pro <![CDATA[<210> 117]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 117]]> Thr Thr Ala Arg Ala Gly Glu Ala Glu Asn Leu Ser Pro Ser Gly Leu 1 5 10 15 Thr Ala Pro <![CDATA[<210> 118]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 118]]> Thr Thr Gly Arg Ala Gly Gly Ala Gly Asn Leu Ala Pro Gly Gly Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 119]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 119]]> Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro Pro Glu Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 120]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 120]]> Thr Thr Gly Arg Ala Gly Gly Ala Ala Asn Leu Ala Pro Thr Gly Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 121]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 121]]> Thr Thr Gly Arg Ala Gly Thr Ala Glu Asn Leu Ala Pro Ser Gly Leu 1 5 10 15 Thr Thr Pro <![CDATA[<210> 122]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 122]]> Thr Thr Gly Arg Ala Gly Ser Ala Thr Asn Leu Gly Pro Gly Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 123]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 123]]> Thr Thr Ala Arg Ala Gly Gly Ala Glu Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Glu Pro <![CDATA[<210> 124]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 124]]> Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 125]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 125]]> Thr Thr Ala Arg Ala Gly Gly Ala Gly Asn Leu Ala Pro Glu Gly Leu 1 5 10 15 Thr Thr Pro <![CDATA[<210> 126]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 126]]> Thr Thr Ser Arg Ala Gly Ala Ala Glu Asn Leu Thr Pro Thr Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 127]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 127]]> Thr Tyr Gly Arg Thr Thr Thr Pro Gly Asn Glu Pro Pro Ala Ser Leu 1 5 10 15 Glu Ala Glu <![CDATA[<210> 128]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 128]]> Thr Tyr Ser Arg Gly Glu Ser Gly Pro Asn Glu Pro Pro Pro Gly Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 129]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 129]]> Ala Trp Gly Arg Thr Gly Ala Ser Glu Asn Glu Thr Pro Ala Pro Leu 1 5 10 15 Gly Gly Glu <![CDATA[<210> 130]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 130]]> Arg Trp Gly Arg Ala Glu Thr Thr Pro Asn Thr Pro Pro Glu Gly Leu 1 5 10 15 Glu Thr Glu <![CDATA[<210> 131]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 131]]> Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Glu Pro Pro Glu Leu 1 5 10 15 Gly Ala Gly <![CDATA[<210> 132]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 132]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Glu Ser <![CDATA[<210> 133]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 133]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Ala Leu 1 5 10 15 Thr Glu Ser <![CDATA[<210> 134]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 134]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu 1 5 10 15 Thr Glu Ser <![CDATA[<210> 135]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 135]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Glu Ser <![CDATA[<210> 136]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 136]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Ala <![CDATA[<210> 137]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 137]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu 1 5 10 15 Thr Gly Ala <![CDATA[<210> 138]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 138]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Gly Ala <![CDATA[<210> 139]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 139]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Glu Ala <![CDATA[<210> 140]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 140]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu 1 5 10 15 Thr Glu Ala <![CDATA[<210> 141]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 141]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu 1 5 10 15 Thr Glu Ala <![CDATA[<210> 142]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 142]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Glu Ala <![CDATA[<210> 143]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 143]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Gly Pro <![CDATA[<210> 144]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 144]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Gly Gly <![CDATA[<210> 145]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 145]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu 1 5 10 15 Thr Gly Gly <![CDATA[<210> 146]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 146]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Ala Leu 1 5 10 15 Thr Gly Gly <![CDATA[<210> 147]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 147]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Gly Gly <![CDATA[<210> 148]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 148]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu 1 5 10 15 Thr Glu Gly <![CDATA[<210> 149]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 149]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu 1 5 10 15 Thr Glu Gly <![CDATA[<210> 150]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 150]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu 1 5 10 15 Thr Glu Gly <![CDATA[<210> 151]]> <![CDATA[<211> 19]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 151]]> Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu 1 5 10 15 Thr Glu Gly <![CDATA[<210> 152]]> <![CDATA[<211> 177]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 152]]> Met Glu Ile Cys Arg Gly Leu Arg Ser His Leu Ile Thr Leu Leu Leu 1 5 10 15 Phe Leu Phe His Ser Glu Thr Ile Cys Arg Pro Ser Gly Arg Lys Ser 20 25 30 Ser Lys Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 35 40 45 Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 50 55 60 Val Asn Leu Glu Glu Lys Ile Asp Val Val Pro Ile Glu Pro His Ala 65 70 75 80 Leu Phe Leu Gly Ile His Gly Gly Lys Met Cys Leu Ser Cys Val Lys 85 90 95 Ser Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp 100 105 110 Leu Ser Glu Asn Arg Lys Gln Asp Lys Arg Phe Ala Phe Ile Arg Ser 115 120 125 Asp Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp 130 135 140 Phe Leu Cys Thr Ala Met Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 145 150 155 160 Met Pro Asp Glu Gly Val Met Val Thr Lys Phe Tyr Phe Gln Glu Asp 165 170 175 Glu <![CDATA[<210> 153]]> <![CDATA[<211> 175]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 153]]> Met Glu Thr Cys Arg Cys Pro Leu Ser Tyr Leu Ile Ser Phe Leu Leu 1 5 10 15 Phe Leu Pro His Ser Glu Thr Ala Cys Arg Leu Gly Lys Arg Pro Cys 20 25 30 Arg Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe Tyr 35 40 45 Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Ser Asn Thr 50 55 60 Lys Leu Glu Glu Lys Leu Asp Val Val Pro Val Glu Pro His Ala Val 65 70 75 80 Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ala Cys Val Lys Ser 85 90 95 Gly Asp Glu Thr Arg Leu Gln Leu Glu Ala Val Asn Ile Thr Asp Leu 100 105 110 Ser Lys Asn Lys Asp Gln Asp Lys Arg Phe Thr Phe Ile Leu Ser Asp 115 120 125 Ser Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly Trp Phe 130 135 140 Leu Cys Thr Ala Leu Glu Ala Asp Arg Pro Val Ser Leu Thr Asn Arg 145 150 155 160 Pro Glu Glu Ala Met Met Val Thr Lys Phe Tyr Phe Gln Lys Glu 165 170 175 <![CDATA[<210> 154]]> <![CDATA[<211> 176]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 154]]> Met Arg Pro Ser Arg Ser Thr Arg Arg His Leu Ile Ser Leu Leu Leu 1 5 10 15 Phe Leu Phe His Ser Glu Thr Ala Cys Arg Pro Ser Gly Lys Arg Pro 20 25 30 Cys Arg Met Gln Ala Phe Arg Ile Trp Asp Val Asn Gln Lys Thr Phe 35 40 45 Tyr Leu Arg Asn Asn Gln Leu Val Ala Gly Tyr Leu Gln Gly Pro Asn 50 55 60 Ala Lys Leu Glu Glu Arg Ile Asp Val Val Pro Leu Glu Pro Gln Leu 65 70 75 80 Leu Phe Leu Gly Ile Gln Arg Gly Lys Leu Cys Leu Ser Cys Val Lys 85 90 95 Ser Gly Asp Lys Met Lys Leu His Leu Glu Ala Val Asn Ile Thr Asp 100 105 110 Leu Gly Lys Asn Lys Glu Gln Asp Lys Arg Phe Thr Phe Ile Arg Ser 115 120 125 Asn Ser Gly Pro Thr Thr Thr Phe Glu Ser Ala Ser Cys Pro Gly Trp 130 135 140 Phe Leu Cys Thr Ala Leu Glu Ala Asp Gln Pro Val Ser Leu Thr Asn 145 150 155 160 Thr Pro Asp Asp Ser Ile Val Val Thr Lys Phe Tyr Phe Gln Glu Asp 165 170 175 <![CDATA[<210> 155]]> <![CDATA[<211> 178]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 155]]> Met Glu Ile Cys Arg Gly Pro Tyr Ser His Leu Ile Ser Leu Leu Leu 1 5 10 15 Ile Leu Leu Phe Arg Ser Glu Ser Ala Gly His Ile Pro Ala Gly Lys 20 25 30 Arg Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys 35 40 45 Thr Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly 50 55 60 Pro Asn Thr Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Phe 65 70 75 80 Arg Asn Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys 85 90 95 Val Lys Ser Gly Asp Asp Thr Lys Leu Gln Leu Glu Glu Val Asn Ile 100 105 110 Thr Asp Leu Asn Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile 115 120 125 Arg Ser Glu Thr Gly Pro Thr Thr Ser Phe Glu Ser Leu Ala Cys Pro 130 135 140 Gly Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp His Pro Val Ser Leu 145 150 155 160 Thr Asn Thr Pro Lys Glu Pro Cys Thr Val Thr Lys Phe Tyr Phe Gln 165 170 175 Glu Asp <![CDATA[<210> 156]]> <![CDATA[<211> 178]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 156]]> Met Glu Ile Cys Trp Gly Pro Tyr Ser His Leu Ile Ser Leu Leu Leu 1 5 10 15 Ile Leu Leu Phe His Ser Glu Ala Ala Cys Arg Pro Ser Gly Lys Arg 20 25 30 Pro Cys Lys Met Gln Ala Phe Arg Ile Trp Asp Thr Asn Gln Lys Thr 35 40 45 Phe Tyr Leu Arg Asn Asn Gln Leu Ile Ala Gly Tyr Leu Gln Gly Pro 50 55 60 Asn Ile Lys Leu Glu Glu Lys Ile Asp Met Val Pro Ile Asp Leu His 65 70 75 80 Ser Val Phe Leu Gly Ile His Gly Gly Lys Leu Cys Leu Ser Cys Ala 85 90 95 Lys Ser Gly Asp Asp Ile Lys Leu Gln Leu Glu Glu Val Asn Ile Thr 100 105 110 Asp Leu Ser Lys Asn Lys Glu Glu Asp Lys Arg Phe Thr Phe Ile Arg 115 120 125 Ser Glu Lys Gly Pro Thr Thr Ser Phe Glu Ser Ala Ala Cys Pro Gly 130 135 140 Trp Phe Leu Cys Thr Thr Leu Glu Ala Asp Arg Pro Val Ser Leu Thr 145 150 155 160 Asn Thr Pro Glu Glu Pro Leu Ile Val Thr Lys Phe Tyr Phe Gln Glu 165 170 175 Asp Gln <![CDATA[<210> 157]]> <![CDATA[<211> 153]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 157]]> Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 1 5 10 15 Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 20 25 30 Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 35 40 45 Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 50 55 60 Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 65 70 75 80 Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 85 90 95 Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 100 105 110 Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 115 120 125 Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 130 135 140 Thr Lys Phe Tyr Phe Gln Glu Asp Glu 145 150 <![CDATA[<210> 158]]> <![CDATA[<211> 178]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 158]]> Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 1 5 10 15 Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 20 25 30 Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 35 40 45 Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 50 55 60 Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 65 70 75 80 Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 85 90 95 Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 100 105 110 Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 115 120 125 Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 130 135 140 Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 145 150 155 160 Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 165 170 175 Arg Asn <![CDATA[<210> 159]]> <![CDATA[<211> 115]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 159]]> Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val Gln Pro Gly Gly 1 5 10 15 Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr Phe Ser Ser Phe 20 25 30 Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly Leu Glu Trp Val 35 40 45 Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val 50 55 60 Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser Lys Asn Thr Leu Tyr Leu 65 70 75 80 Gln Met Asn Ser Leu Arg Ala Glu Asp Thr Ala Val Tyr Tyr Cys Ala 85 90 95 Lys Pro Phe Pro Tyr Phe Asp Tyr Trp Gly Gln Gly Thr Leu Val Thr 100 105 110 Val Ser Ser 115 <![CDATA[<210> 160]]> <![CDATA[<211> 108]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 160]]> Glu Ile Val Leu Thr Gln Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly 1 5 10 15 Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Val Ser Ser Ser 20 25 30 Phe Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu 35 40 45 Ile Tyr Tyr Ala Ser Ser Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser 50 55 60 Gly Ser Gly Ser Gly Thr Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu 65 70 75 80 Pro Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro 85 90 95 Pro Thr Phe Gly Gln Gly Thr Lys Val Glu Ile Lys 100 105 <![CDATA[<210> 161]]> <![CDATA[<211> 5]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 161]]> Ser Phe Ser Met Ser 1 5 <![CDATA[<210> 162]]> <![CDATA[<211> 17]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 162]]> Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr Ala Asp Ser Val Lys 1 5 10 15 Gly <![CDATA[<210> 163]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 163]]> Pro Phe Pro Tyr Phe Asp Tyr 1 5 <![CDATA[<210> 164]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 164]]> Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala 1 5 10 <![CDATA[<210> 165]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 165]]> Tyr Ala Ser Ser Arg Ala Thr 1 5 <![CDATA[<210> 166]]> <![CDATA[<211> 9]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 166]]> Gln Gln Thr Gly Arg Ile Pro Pro Thr 1 5 <![CDATA[<210> 167]]> <![CDATA[<400> 167]]> 000 <![CDATA[<210> 168]]> <![CDATA[<400> 168]]> 000 <![CDATA[<210> 169]]> <![CDATA[<400> 169]]> 000 <![CDATA[<210> 170]]> <![CDATA[<400> 170]]> 000 <![CDATA[<210> 171]]> <![CDATA[<400> 171]]> 000 <![CDATA[<210> 172]]> <![CDATA[<400> 172]]> 000 <![CDATA[<210> 173]]> <![CDATA[<400> 173]]> 000 <![CDATA[<210> 174]]> <![CDATA[<400> 174]]> 000 <![CDATA[<210> 175]]> <![CDATA[<400> 175]]> 000 <![CDATA[<210> 176]]> <![CDATA[<400> 176]]> 000 <![CDATA[<210> 177]]> <![CDATA[<400> 177]]> 000 <![CDATA[<210> 178]]> <![CDATA[<400> 178]]> 000 <![CDATA[<210> 179]]> <![CDATA[<400> 179]]> 000 <![CDATA[<210> 180]]> <![CDATA[<400> 180]]> 000 <![CDATA[<210> 181]]> <![CDATA[<400> 181]]> 000 <![CDATA[<210> 182]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 182]]> Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 1 5 10 <![CDATA[<210> 183]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 183]]> Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 1 5 10 <![CDATA[<210> 184]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 184]]> Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 1 5 10 <![CDATA[<210> 185]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 185]]> Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 1 5 10 <![CDATA[<210> 186]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 186]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1 5 10 <![CDATA[<210> 187]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 187]]> Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1 5 10 <![CDATA[<210> 188]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 188]]> Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1 5 10 <![CDATA[<210> 189]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 189]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1 5 10 <![CDATA[<210> 190]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 190]]> Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 1 5 10 <![CDATA[<210> 191]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 191]]> Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 1 5 10 <![CDATA[<210> 192]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 192]]> Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 1 5 10 <![CDATA[<210> 193]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 193]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 1 5 10 <![CDATA[<210> 194]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 194]]> Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 1 5 10 <![CDATA[<210> 195]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 195]]> Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 1 5 10 <![CDATA[<210> 196]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 196]]> Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 1 5 10 <![CDATA[<210> 197]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 197]]> Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 1 5 10 <![CDATA[<210> 198]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 198]]> Gly Glu Pro Ala Gly Ser Pro Thr Ser Thr Ser Glu 1 5 10 <![CDATA[<210> 199]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 199]]> Gly Thr Gly Glu Pro Ser Ser Thr Pro Ala Ser Glu 1 5 10 <![CDATA[<210> 200]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 200]]> Gly Ser Gly Pro Ser Thr Glu Ser Ala Pro Thr Glu 1 5 10 <![CDATA[<210> 201]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 201]]> Gly Ser Glu Thr Pro Ser Gly Pro Ser Glu Thr Ala 1 5 10 <![CDATA[<210> 202]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 202]]> Gly Pro Ser Glu Thr Ser Thr Ser Glu Pro Gly Ala 1 5 10 <![CDATA[<210> 203]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 203]]> Gly Ser Pro Ser Glu Pro Thr Glu Gly Thr Ser Ala 1 5 10 <![CDATA[<210> 204]]> <![CDATA[<211> 144]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 204]]> Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 50 55 60 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly 65 70 75 80 Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 100 105 110 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 115 120 125 Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 <![CDATA[<210> 205]]> <![CDATA[<211> 144]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 205]]> Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Pro 1 5 10 15 Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 20 25 30 Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 50 55 60 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser 65 70 75 80 Ser Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 100 105 110 Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 130 135 140 <![CDATA[<210> 206]]> <![CDATA[<211> 288]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 206]]> Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 20 25 30 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 35 40 45 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 65 70 75 80 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 100 105 110 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 115 120 125 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 165 170 175 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 180 185 190 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 195 200 205 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 210 215 220 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 245 250 255 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 275 280 285 <![CDATA[<210> 207]]> <![CDATA[<211> 504]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (63)..(63)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (207)..(207)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 207]]> Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Xaa Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 145 150 155 160 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 165 170 175 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 180 185 190 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Xaa Pro 195 200 205 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 210 215 220 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 225 230 235 240 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 245 250 255 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 260 265 270 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 275 280 285 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 290 295 300 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 305 310 315 320 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 325 330 335 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 340 345 350 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 355 360 365 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 370 375 380 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 385 390 395 400 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 405 410 415 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 420 425 430 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 435 440 445 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 450 455 460 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 465 470 475 480 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 485 490 495 Gly Thr Ser Ser Thr Gly Ser Pro 500 <![CDATA[<210> 208]]> <![CDATA[<211> 540]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 208]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 1 5 10 15 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 85 90 95 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 130 135 140 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 165 170 175 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 180 185 190 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 225 230 235 240 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 275 280 285 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 290 295 300 Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly 305 310 315 320 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 325 330 335 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 340 345 350 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 370 375 380 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 420 425 430 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 435 440 445 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 450 455 460 Ser Ala Ser Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 465 470 475 480 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 485 490 495 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 500 505 510 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 515 520 525 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 530 535 540 <![CDATA[<210> 209]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 209]]> Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 1 5 10 15 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 20 25 30 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 35 40 45 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 50 55 60 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 65 70 75 80 Glu Gly Gly Pro Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 85 90 95 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 100 105 110 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 115 120 125 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 130 135 140 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 145 150 155 160 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 165 170 175 Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 180 185 190 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 195 200 205 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 210 215 220 Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 225 230 235 240 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 245 250 255 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 260 265 270 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 275 280 285 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro 290 295 300 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 305 310 315 320 Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 325 330 335 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro 340 345 350 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser 355 360 365 Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 370 375 380 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 385 390 395 400 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 405 410 415 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 420 425 430 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 435 440 445 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 450 455 460 Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 465 470 475 480 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu 485 490 495 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 500 505 510 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 515 520 525 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Glu Gly 530 535 540 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 545 550 555 560 Glu Gly Gly Pro Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 565 570 575 <![CDATA[<210> 210]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 210]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 <![CDATA[<210> 211]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 211]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 1 5 10 15 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 85 90 95 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 130 135 140 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 165 170 175 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 180 185 190 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 225 230 235 240 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 275 280 285 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 290 295 300 Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly 305 310 315 320 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 325 330 335 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 340 345 350 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 370 375 380 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 420 425 430 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 435 440 445 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 450 455 460 Ser Ala Ser Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 465 470 475 480 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 485 490 495 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 500 505 510 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 515 520 525 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 530 535 540 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 545 550 555 560 Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 565 570 575 <![CDATA[<210> 212]]> <![CDATA[<211> 836]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 212]]> Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 1 5 10 15 Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro Gly Gly Ser Ser 20 25 30 Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 35 40 45 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro 50 55 60 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser 65 70 75 80 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 85 90 95 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro 100 105 110 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 115 120 125 Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 130 135 140 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 145 150 155 160 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 165 170 175 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 180 185 190 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 195 200 205 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 210 215 220 Ser Gly Ser Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 225 230 235 240 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 245 250 255 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro 260 265 270 Gly Glu Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 275 280 285 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Glu Gly 290 295 300 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 305 310 315 320 Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 325 330 335 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 340 345 350 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 355 360 365 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 370 375 380 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly 385 390 395 400 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro 405 410 415 Gly Glu Ser Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 420 425 430 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Glu Gly 435 440 445 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 450 455 460 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 465 470 475 480 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro 485 490 495 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu 500 505 510 Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 515 520 525 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Glu Gly 530 535 540 Ser Ser Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 545 550 555 560 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Glu Gly 565 570 575 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro 580 585 590 Gly Glu Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 595 600 605 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly 610 615 620 Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro Gly Gly Ser Ser 625 630 635 640 Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 645 650 655 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Glu Gly 660 665 670 Ser Ser Gly Pro Gly Glu Ser Ser Gly Glu Ser Pro Gly Gly Ser Ser 675 680 685 Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 690 695 700 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 705 710 715 720 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 725 730 735 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 740 745 750 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 755 760 765 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 770 775 780 Glu Gly Gly Pro Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 785 790 795 800 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 805 810 815 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu 820 825 830 Ser Gly Ser Ser 835 <![CDATA[<210> 213]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 213]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <![CDATA[<210> 214]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (430)..(432)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (443)..(446)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 214]]> Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 1 5 10 15 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 85 90 95 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 130 135 140 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 165 170 175 Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 180 185 190 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 225 230 235 240 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 275 280 285 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 290 295 300 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser 305 310 315 320 Ser Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 325 330 335 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 340 345 350 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 370 375 380 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Pro Xaa Xaa Xaa 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Xaa Xaa Xaa Xaa Ser Glu 435 440 445 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 450 455 460 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 465 470 475 480 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 500 505 510 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 515 520 525 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 530 535 540 Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 565 570 575 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro 625 630 635 640 Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser 645 650 655 Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Ser 675 680 685 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 690 695 700 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 705 710 715 720 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser 725 730 735 Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 755 760 765 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 770 775 780 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 785 790 795 800 Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 805 810 815 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser 820 825 830 Gly Glu Ser Ser Thr Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 835 840 845 Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 865 870 875 <![CDATA[<210> 215]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 215]]> Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 145 150 155 160 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 165 170 175 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 180 185 190 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 195 200 205 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 210 215 220 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 225 230 235 240 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 245 250 255 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 260 265 270 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 275 280 285 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 290 295 300 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 305 310 315 320 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 325 330 335 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 340 345 350 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 355 360 365 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 370 375 380 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 385 390 395 400 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 405 410 415 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 420 425 430 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 435 440 445 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 450 455 460 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 465 470 475 480 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 485 490 495 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 500 505 510 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 515 520 525 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 530 535 540 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 545 550 555 560 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 565 570 575 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 580 585 590 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 595 600 605 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 610 615 620 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 625 630 635 640 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 645 650 655 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 660 665 670 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 675 680 685 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 690 695 700 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 705 710 715 720 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 725 730 735 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 740 745 750 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 755 760 765 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 770 775 780 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 785 790 795 800 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 805 810 815 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 820 825 830 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 835 840 845 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 850 855 860 <![CDATA[<210> 216]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 216]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu Ser 435 440 445 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 450 455 460 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 500 505 510 Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 515 520 525 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 530 535 540 Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 545 550 555 560 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 565 570 575 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser Ser 580 585 590 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 595 600 605 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 625 630 635 640 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 645 650 655 Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 675 680 685 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr Pro 725 730 735 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 740 745 750 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 755 760 765 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 770 775 780 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 785 790 795 800 Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 805 810 815 Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly 820 825 830 Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 835 840 845 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 850 855 860 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 865 870 875 <![CDATA[<210> 217]]> <![CDATA[<211> 913]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 217]]> Met Ala Glu Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Pro 1 5 10 15 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 20 25 30 Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 35 40 45 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 65 70 75 80 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 85 90 95 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 100 105 110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 195 200 205 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 210 215 220 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 225 230 235 240 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 275 280 285 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 290 295 300 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 305 310 315 320 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 340 345 350 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 355 360 365 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 405 410 415 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 435 440 445 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 450 455 460 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 485 490 495 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 515 520 525 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 530 535 540 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 565 570 575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 580 585 590 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 625 630 635 640 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 645 650 655 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 660 665 670 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 675 680 685 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 705 710 715 720 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 740 745 750 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 755 760 765 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 770 775 780 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 785 790 795 800 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 805 810 815 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 820 825 830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 835 840 845 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 850 855 860 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 865 870 875 880 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 885 890 895 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 900 905 910 Pro <![CDATA[<210> 218]]> <![CDATA[<211> 924]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 218]]> Met Ala Glu Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser 1 5 10 15 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 20 25 30 Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 35 40 45 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 50 55 60 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 65 70 75 80 Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly 85 90 95 Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr 100 105 110 Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro 115 120 125 Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser 130 135 140 Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu 145 150 155 160 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 180 185 190 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 210 215 220 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 225 230 235 240 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 290 295 300 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 305 310 315 320 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 340 345 350 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 355 360 365 Thr Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 370 375 380 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 385 390 395 400 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser 405 410 415 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 435 440 445 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 450 455 460 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 465 470 475 480 Pro Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu 485 490 495 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 500 505 510 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 530 535 540 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 545 550 555 560 Ser Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 565 570 575 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 580 585 590 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 595 600 605 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 610 615 620 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser 625 630 635 640 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu 645 650 655 Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 675 680 685 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu 690 695 700 Gly Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 705 710 715 720 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 725 730 735 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 740 745 750 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 755 760 765 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr 770 775 780 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 785 790 795 800 Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 805 810 815 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 820 825 830 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 835 840 845 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 850 855 860 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 865 870 875 880 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro 885 890 895 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 900 905 910 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 915 920 <![CDATA[<210> 219]]> <![CDATA[<211> 1318]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 219]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Pro Glu Pro Thr Gly Pro Ala Pro Ser Gly Gly Ser Glu Pro Ala 435 440 445 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 450 455 460 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 485 490 495 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 500 505 510 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 515 520 525 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 530 535 540 Ser Pro Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 565 570 575 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 625 630 635 640 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 645 650 655 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 660 665 670 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 675 680 685 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Pro Ser 725 730 735 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 755 760 765 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 770 775 780 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 785 790 795 800 Ser Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly 805 810 815 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro 820 825 830 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr 835 840 845 Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Ala Ser 865 870 875 880 Gly Ala Pro Ser Thr Gly Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr 885 890 895 Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr 900 905 910 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala 915 920 925 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 930 935 940 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 945 950 955 960 Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser 965 970 975 Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly 980 985 990 Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr 995 1000 1005 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 1010 1015 1020 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1025 1030 1035 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1040 1045 1050 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 1055 1060 1065 Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 1070 1075 1080 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 1085 1090 1095 Ser Ala Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1100 1105 1110 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1115 1120 1125 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1130 1135 1140 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 1145 1150 1155 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1160 1165 1170 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala 1175 1180 1185 Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro 1190 1195 1200 Ser Gly Ala Thr Gly Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 1205 1210 1215 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala 1220 1225 1230 Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser 1235 1240 1245 Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly 1250 1255 1260 Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 1265 1270 1275 Ser Ser Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1280 1285 1290 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1295 1300 1305 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1310 1315 <![CDATA[<210> 220]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 220]]> Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 1 5 10 15 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 35 40 45 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro 50 55 60 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 65 70 75 80 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 85 90 95 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 115 120 125 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 130 135 140 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr 145 150 155 160 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 180 185 190 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Glu 195 200 205 Pro Ser Thr Ser Glu Pro Gly Ala Gly Ser Gly Ala Ser Glu Pro Thr 210 215 220 Ser Thr Glu Pro Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 225 230 235 240 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro 245 250 255 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 275 280 285 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 325 330 335 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 355 360 365 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 385 390 395 400 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 405 410 415 Ser Thr Glu Pro Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 420 425 430 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 450 455 460 Ser Thr Glu Pro Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 465 470 475 480 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 500 505 510 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 515 520 525 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 530 535 540 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 545 550 555 560 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 565 570 575 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 580 585 590 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 595 600 605 Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 610 615 620 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Glu Pro Ser Thr Ser 645 650 655 Glu Pro Gly Ala Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 660 665 670 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 675 680 685 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 690 695 700 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 705 710 715 720 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 725 730 735 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 740 745 750 Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Glu 770 775 780 Pro Ser Thr Ser Glu Pro Gly Ala Gly Ser Glu Pro Ala Thr Ser Gly 785 790 795 800 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 835 840 845 Ser Thr Glu Pro Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 850 855 860 <![CDATA[<210> 221]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 221]]> Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Thr Ala Gly Ser Glu Thr 20 25 30 Ser Thr Glu Ala Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 35 40 45 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Ser Glu Thr 50 55 60 Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu 65 70 75 80 Gly Ser Ala Ser Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 85 90 95 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr 100 105 110 Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu 115 120 125 Gly Ser Ala Ser Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 130 135 140 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr Ala Thr Ser Gly 165 170 175 Ser Glu Thr Ala Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 180 185 190 Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser Gly Ser Glu Thr 195 200 205 Ala Thr Ser Gly Ser Glu Thr Ala Gly Ser Glu Thr Ala Thr Ser Gly 210 215 220 Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 225 230 235 240 Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala Gly Thr Ser Glu 245 250 255 Ser Ala Thr Ser Glu Ser Gly Ala Gly Thr Ser Thr Glu Ala Ser Glu 260 265 270 Gly Ser Ala Ser Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 275 280 285 Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala Gly Ser Thr Ala 290 295 300 Gly Ser Glu Thr Ser Thr Glu Ala Gly Ser Glu Thr Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Ala Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 325 330 335 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr 340 345 350 Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu Ser Ala Thr Ser 355 360 365 Glu Ser Gly Ala Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 370 375 380 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Ser Glu Thr 385 390 395 400 Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu 405 410 415 Gly Ser Ala Ser Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 420 425 430 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu 435 440 445 Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Thr Ala Gly Ser Glu Thr 450 455 460 Ser Thr Glu Ala Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 465 470 475 480 Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala Gly Thr Ser Thr 485 490 495 Glu Ala Ser Glu Gly Ser Ala Ser Gly Ser Thr Ala Gly Ser Glu Thr 500 505 510 Ser Thr Glu Ala Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 515 520 525 Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser Gly Ser Thr Ala 530 535 540 Gly Ser Glu Thr Ser Thr Glu Ala Gly Ser Glu Thr Ala Thr Ser Gly 545 550 555 560 Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 565 570 575 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr 580 585 590 Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu Ser Ala Thr Ser 595 600 605 Glu Ser Gly Ala Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 610 615 620 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu 625 630 635 640 Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr Ala Thr Ser Gly 645 650 655 Ser Glu Thr Ala Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 660 665 670 Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser Gly Ser Thr Ala 675 680 685 Gly Ser Glu Thr Ser Thr Glu Ala Gly Ser Thr Ala Gly Ser Glu Thr 690 695 700 Ser Thr Glu Ala Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 705 710 715 720 Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala Gly Thr Ser Glu 725 730 735 Ser Ala Thr Ser Glu Ser Gly Ala Gly Ser Glu Thr Ala Thr Ser Gly 740 745 750 Ser Glu Thr Ala Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 755 760 765 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Thr 770 775 780 Glu Ala Ser Glu Gly Ser Ala Ser Gly Thr Ser Glu Ser Ala Thr Ser 785 790 795 800 Glu Ser Gly Ala Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 805 810 815 Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala Gly Thr Ser Glu 820 825 830 Ser Ala Thr Ser Glu Ser Gly Ala Gly Thr Ser Glu Ser Ala Thr Ser 835 840 845 Glu Ser Gly Ala Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 850 855 860 <![CDATA[<210> 222]]> <![CDATA[<400> 222]]> 000 <![CDATA[<210> 223]]> <![CDATA[<400> 223]]> 000 <![CDATA[<210> 224]]> <![CDATA[<400> 224]]> 000 <![CDATA[<210> 225]]> <![CDATA[<400> 225]]> 000 <![CDATA[<210> 226]]> <![CDATA[<400> 226]]> 000 <![CDATA[<210> 227]]> <![CDATA[<400> 227]]> 000 <![CDATA[<210> 228]]> <![CDATA[<400> 228]]> 000 <![CDATA[<210> 229]]> <![CDATA[<400> 229]]> 000 <![CDATA[<210> 230]]> <![CDATA[<400> 230]]> 000 <![CDATA[<210> 231]]> <![CDATA[<400> 231]]> 000 <![CDATA[<210> 232]]> <![CDATA[<400> 232]]> 000 <![CDATA[<210> 233]]> <![CDATA[<400> 233]]> 000 <![CDATA[<210> 234]]> <![CDATA[<400> 234]]> 000 <![CDATA[<210> 235]]> <![CDATA[<400> 235]]> 000 <![CDATA[<210> 236]]> <![CDATA[<400> 236]]> 000 <![CDATA[<210> 237]]> <![CDATA[<400> 237]]> 000 <![CDATA[<210> 238]]> <![CDATA[<400> 238]]> 000 <![CDATA[<210> 239]]> <![CDATA[<400> 239]]> 000 <![CDATA[<210> 240]]> <![CDATA[<400> 240]]> 000 <![CDATA[<210> 241]]> <![CDATA[<400> 241]]> 000 <![CDATA[<210> 242]]> <![CDATA[<400> 242]]> 000 <![CDATA[<210> 243]]> <![CDATA[<400> 243]]> 000 <![CDATA[<210> 244]]> <![CDATA[<400> 244]]> 000 <![CDATA[<210> 245]]> <![CDATA[<400> 245]]> 000 <![CDATA[<210> 246]]> <![CDATA[<400> 246]]> 000 <![CDATA[<210> 247]]> <![CDATA[<211> 432]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 247]]> ggtagcgaac cggcaacttc cggctctgaa accccaggta cttctgaaag cgctactcct 60 gagtctggcc caggtagcga acctgctacc tctggctctg aaaccccagg tagcccggca 120 ggctctccga cttccaccga ggaaggtacc tctactgaac cttctgaggg tagcgctcca 180 ggtagcgaac cggcaacctc tggctctgaa accccaggta gcgaacctgc tacctccggc 240 tctgaaactc caggtagcga accggctact tccggttctg aaactccagg tacctctacc 300 gaaccttccg aaggcagcgc accaggtact tctgaaagcg caacccctga atccggtcca 360 ggtagcgaac cggctacttc tggctctgag actccaggta cttctaccga accgtccgaa 420 ggtagcgcac ca 432 <![CDATA[<210> 248]]> <![CDATA[<211> 432]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 248]]> ggtacttcta ctccggaaag cggttccgca tctccaggta cttctcctag cggtgaatct 60 tctactgctc caggtacctc tcctagcggc gaatcttcta ctgctccagg ttctaccagc 120 tctaccgctg aatctcctgg cccaggttct accagcgaat ccccgtctgg caccgcacca 180 ggttctacta gctctaccgc agaatctccg ggtccaggta cttcccctag cggtgaatct 240 tctactgctc caggtacctc tactccggaa agcggctccg catctccagg ttctactagc 300 tctactgctg aatctcctgg tccaggtacc tcccctagcg gcgaatcttc tactgctcca 360 ggtacctctc ctagcggcga atcttctacc gctccaggta cctcccctag cggtgaatct 420 tctaccgcac ca 432 <![CDATA[<210> 249]]> <![CDATA[<211> 864]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 249]]> ggtacctctg aaagcgcaac tcctgagtct ggcccaggta gcgaacctgc tacctccggc 60 tctgagactc caggtacctc tgaaagcgca accccggaat ctggtccagg tagcgaacct 120 gcaacctctg gctctgaaac cccaggtacc tctgaaagcg ctactcctga atctggccca 180 ggtacttcta ctgaaccgtc cgagggcagc gcaccaggta gccctgctgg ctctccaacc 240 tccaccgaag aaggtacctc tgaaagcgca acccctgaat ccggcccagg tagcgaaccg 300 gcaacctccg gttctgaaac cccaggtact tctgaaagcg ctactcctga gtccggccca 360 ggtagcccgg ctggctctcc gacttccacc gaggaaggta gcccggctgg ctctccaact 420 tctactgaag aaggtacttc taccgaacct tccgagggca gcgcaccagg tacttctgaa 480 agcgctaccc ctgagtccgg cccaggtact tctgaaagcg ctactcctga atccggtcca 540 ggtacttctg aaagcgctac cccggaatct ggcccaggta gcgaaccggc tacttctggt 600 tctgaaaccc caggtagcga accggctacc tccggttctg aaactccagg tagcccagca 660 ggctctccga cttccactga ggaaggtact tctactgaac cttccgaagg cagcgcacca 720 ggtacctcta ctgaaccttc tgagggcagc gctccaggta gcgaacctgc aacctctggc 780 tctgaaaccc caggtacctc tgaaagcgct actcctgaat ctggcccagg tacttctact 840 gaaccgtccg agggcagcgc acca 864 <![CDATA[<210> 250]]> <![CDATA[<211> 1728]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 250]]> ggtagcccgg ctggctctcc tacctctact gaggaaggta cttctgaaag cgctactcct 60 gagtctggtc caggtacctc tactgaaccg tccgaaggta gcgctccagg tagcccagca 120 ggctctccga cttccactga ggaaggtact tctactgaac cttccgaagg cagcgcacca 180 ggtacctcta ctgaaccttc tgagggcagc gctccaggta cttctgaaag cgctaccccg 240 gaatctggcc caggtagcga accggctact tctggttctg aaaccccagg tagcgaaccg 300 gctacctccg gttctgaaac tccaggtagc ccggcaggct ctccgacctc tactgaggaa 360 ggtacttctg aaagcgcaac cccggagtcc ggcccaggta cctctaccga accgtctgag 420 ggcagcgcac caggtacttc taccgaaccg tccgagggta gcgcaccagg tagcccagca 480 ggttctccta cctccaccga ggaaggtact tctaccgaac cgtccgaggg tagcgcacca 540 ggtacctcta ctgaaccttc tgagggcagc gctccaggta cttctgaaag cgctaccccg 600 gagtccggtc caggtacttc tactgaaccg tccgaaggta gcgcaccagg tacttctgaa 660 agcgcaaccc ctgaatccgg tccaggtagc gaaccggcta cttctggctc tgagactcca 720 ggtacttcta ccgaaccgtc cgaaggtagc gcaccaggta cttctactga accgtctgaa 780 ggtagcgcac caggtacttc tgaaagcgca accccggaat ccggcccagg tacctctgaa 840 agcgcaaccc cggagtccgg cccaggtagc cctgctggct ctccaacctc caccgaagaa 900 ggtacctctg aaagcgcaac ccctgaatcc ggcccaggta gcgaaccggc aacctccggt 960 tctgaaaccc caggtacctc tgaaagcgct actccggagt ctggcccagg tacctctact 1020 gaaccgtctg agggtagcgc tccaggtact tctactgaac cgtccgaagg tagcgcacca 1080 ggtacttcta ccgaaccgtc cgaaggcagc gctccaggta cctctactga accttccgag 1140 ggcagcgctc caggtacctc taccgaacct tctgaaggta gcgcaccagg tacttctacc 1200 gaaccgtccg agggtagcgc accaggtagc ccagcaggtt ctcctacctc caccgaggaa 1260 ggtacttcta ccgaaccgtc cgagggtagc gcaccaggta cctctgaaag cgcaactcct 1320 gagtctggcc caggtagcga acctgctacc tccggctctg agactccagg tacctctgaa 1380 agcgcaaccc cggaatctgg tccaggtagc gaacctgcaa cctctggctc tgaaacccca 1440 ggtacctctg aaagcgctac tcctgaatct ggcccaggta cttctactga accgtccgag 1500 ggcagcgcac caggtacttc tgaaagcgct actcctgagt ccggcccagg tagcccggct 1560 ggctctccga cttccaccga ggaaggtagc ccggctggct ctccaacttc tactgaagaa 1620 ggtagcccgg caggctctcc gacctctact gaggaaggta cttctgaaag cgcaaccccg 1680 gagtccggcc caggtacctc taccgaaccg tctgagggca gcgcacca 1728 <![CDATA[<210> 251]]> <![CDATA[<211> 1728]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 251]]> ggttctacta gctctaccgc tgaatctcct ggcccaggtt ccactagctc taccgcagaa 60 tctccgggcc caggttctac tagcgaatcc ccttctggta ccgctccagg ttctactagc 120 tctaccgctg aatctccggg tccaggttct accagctcta ctgcagaatc tcctggccca 180 ggtacttcta ctccggaaag cggttccgct tctccaggtt ctaccagcga atctccttct 240 ggcaccgctc caggtacctc tcctagcggc gaatcttcta ccgctccagg ttctactagc 300 gaatctcctt ctggcactgc accaggttct accagcgaat ctccttctgg caccgctcca 360 ggtacctctc ctagcggcga atcttctacc gctccaggtt ctactagcga atctccttct 420 ggcactgcac caggttctac cagcgaatct ccttctggca ccgctccagg tacctctcct 480 agcggcgaat cttctaccgc tccaggttct actagcgaat ctccttctgg cactgcacca 540 ggttctacta gcgaatctcc ttctggcact gcaccaggtt ctaccagcga atctccgtct 600 ggcactgcac caggtacctc tacccctgaa agcggttccg cttctccagg ttctactagc 660 gaatctcctt ctggtaccgc tccaggtact tctacccctg aaagcggctc cgcttctcca 720 ggttccacta gctctaccgc tgaatctccg ggtccaggtt ctactagctc tactgcagaa 780 tctcctggcc caggtacctc tactccggaa agcggctctg catctccagg tacttctacc 840 cctgaaagcg gttctgcatc tccaggttct actagcgaat ccccgtctgg taccgcacca 900 ggtacttcta ccccggaaag cggctctgct tctccaggta cttctacccc ggaaagcggc 960 tccgcatctc caggttctac tagcgaatct ccttctggta ccgctccagg ttctaccagc 1020 gaatccccgt ctggtactgc tccaggttct accagcgaat ctccttctgg tactgcacca 1080 ggttctacta gctctactgc agaatctcct ggcccaggta cctctactcc ggaaagcggc 1140 tctgcatctc caggtacttc tacccctgaa agcggttctg catctccagg ttctactagc 1200 gaatctcctt ctggcactgc accaggttct accagcgaat ctccgtctgg cactgcacca 1260 ggtacctcta cccctgaaag cggttccgct tctccaggtt ctactagcga atctccttct 1320 ggcactgcac caggttctac cagcgaatct ccgtctggca ctgcaccagg tacctctacc 1380 cctgaaagcg gttccgcttc tccaggtact tctccgagcg gtgaatcttc taccgcacca 1440 ggttctacta gctctaccgc tgaatctccg ggcccaggta cttctccgag cggtgaatct 1500 tctactgctc caggttccac tagctctact gctgaatctc ctggcccagg tacttctact 1560 ccggaaagcg gttccgcttc tccaggttct actagcgaat ctccgtctgg caccgcacca 1620 ggttctacta gctctactgc agaatctcct ggcccaggta cctctactcc ggaaagcggc 1680 tctgcatctc caggtacttc tacccctgaa agcggttctg catctcca 1728 <![CDATA[<210> 252]]> <![CDATA[<211> 2625]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 252]]> ggtacttcta ctgaaccgtc tgaaggcagc gcaccaggta gcgaaccggc tacttccggt 60 tctgaaaccc caggtagccc agcaggttct ccaacttcta ctgaagaagg ttctaccagc 120 tctaccgcag aatctcctgg tccaggtacc tctactccgg aaagcggctc tgcatctcca 180 ggttctacta gcgaatctcc ttctggcact gcaccaggtt ctactagcga atccccgtct 240 ggtactgctc caggtacttc tactcctgaa agcggttccg cttctccagg tacctctact 300 ccggaaagcg gttctgcatc tccaggtagc gaaccggcaa cctccggctc tgaaacccca 360 ggtacctctg aaagcgctac tcctgaatcc ggcccaggta gcccggcagg ttctccgact 420 tccactgagg aaggtacctc tactgaacct tctgagggca gcgctccagg tacttctgaa 480 agcgctaccc cggagtccgg tccaggtact tctactgaac cgtccgaagg tagcgcacca 540 ggtacttcta ccgaaccgtc cgagggtagc gcaccaggta gcccagcagg ttctcctacc 600 tccaccgagg aaggtacttc taccgaaccg tccgagggta gcgcaccagg tacttctacc 660 gaaccttccg agggcagcgc accaggtact tctgaaagcg ctacccctga gtccggccca 720 ggtacttctg aaagcgctac tcctgaatcc ggtccaggta cctctactga accttccgaa 780 ggcagcgctc caggtacctc taccgaaccg tccgagggca gcgcaccagg tacttctgaa 840 agcgcaaccc ctgaatccgg tccaggtact tctactgaac cttccgaagg tagcgctcca 900 ggtagcgaac ctgctacttc tggttctgaa accccaggta gcccggctgg ctctccgacc 960 tccaccgagg aaggtagctc taccccgtct ggtgctactg gttctccagg tactccgggc 1020 agcggtactg cttcttcctc tccaggtagc tctacccctt ctggtgctac tggctctcca 1080 ggtacctcta ccgaaccgtc cgagggtagc gcaccaggta cctctactga accgtctgag 1140 ggtagcgctc caggtagcga accggcaacc tccggttctg aaactccagg tagccctgct 1200 ggctctccga cttctactga ggaaggtagc ccggctggtt ctccgacttc tactgaggaa 1260 ggtacttcta ccgaaccttc cgaaggtagc gctccaggtg caagcgcaag cggcgcgcca 1320 agcacgggag gtacttctga aagcgctact cctgagtccg gcccaggtag cccggctggc 1380 tctccgactt ccaccgagga aggtagcccg gctggctctc caacttctac tgaagaaggt 1440 tctaccagct ctaccgctga atctcctggc ccaggttcta ctagcgaatc tccgtctggc 1500 accgcaccag gtacttcccc tagcggtgaa tcttctactg caccaggtac ccctggcagc 1560 ggtaccgctt cttcctctcc aggtagctct accccgtctg gtgctactgg ctctccaggt 1620 tctagcccgt ctgcatctac cggtaccggc ccaggtagcg aaccggcaac ctccggctct 1680 gaaactccag gtacttctga aagcgctact ccggaatccg gcccaggtag cgaaccggct 1740 acttccggct ctgaaacccc aggttccacc agctctactg cagaatctcc gggcccaggt 1800 tctactagct ctactgcaga atctccgggt ccaggtactt ctcctagcgg cgaatcttct 1860 accgctccag gtagcgaacc ggcaacctct ggctctgaaa ctccaggtag cgaacctgca 1920 acctccggct ctgaaacccc aggtacttct actgaacctt ctgagggcag cgcaccaggt 1980 tctaccagct ctaccgcaga atctcctggt ccaggtacct ctactccgga aagcggctct 2040 gcatctccag gttctactag cgaatctcct tctggcactg caccaggtac ttctaccgaa 2100 ccgtccgaag gcagcgctcc aggtacctct actgaacctt ccgagggcag cgctccaggt 2160 acctctaccg aaccttctga aggtagcgca ccaggtagct ctactccgtc tggtgcaacc 2220 ggctccccag gttctagccc gtctgcttcc actggtactg gcccaggtgc ttccccgggc 2280 accagctcta ctggttctcc aggtagcgaa cctgctacct ccggttctga aaccccaggt 2340 acctctgaaa gcgcaactcc ggagtctggt ccaggtagcc ctgcaggttc tcctacctcc 2400 actgaggaag gtagctctac tccgtctggt gcaaccggct ccccaggttc tagcccgtct 2460 gcttccactg gtactggccc aggtgcttcc ccgggcacca gctctactgg ttctccaggt 2520 acctctgaaa gcgctactcc ggagtctggc ccaggtacct ctactgaacc gtctgagggt 2580 agcgctccag gtacttctac tgaaccgtcc gaaggtagcg cacca 2625 <![CDATA[<210> 253]]> <![CDATA[<211> 2592]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 253]]> ggtagcccgg ctggctctcc tacctctact gaggaaggta cttctgaaag cgctactcct 60 gagtctggtc caggtacctc tactgaaccg tccgaaggta gcgctccagg tagcccagca 120 ggctctccga cttccactga ggaaggtact tctactgaac cttccgaagg cagcgcacca 180 ggtacctcta ctgaaccttc tgagggcagc gctccaggta cttctgaaag cgctaccccg 240 gaatctggcc caggtagcga accggctact tctggttctg aaaccccagg tagcgaaccg 300 gctacctccg gttctgaaac tccaggtagc ccggcaggct ctccgacctc tactgaggaa 360 ggtacttctg aaagcgcaac cccggagtcc ggcccaggta cctctaccga accgtctgag 420 ggcagcgcac caggtacttc taccgaaccg tccgagggta gcgcaccagg tagcccagca 480 ggttctccta cctccaccga ggaaggtact tctaccgaac cgtccgaggg tagcgcacca 540 ggtacctcta ctgaaccttc tgagggcagc gctccaggta cttctgaaag cgctaccccg 600 gagtccggtc caggtacttc tactgaaccg tccgaaggta gcgcaccagg tacttctgaa 660 agcgcaaccc ctgaatccgg tccaggtagc gaaccggcta cttctggctc tgagactcca 720 ggtacttcta ccgaaccgtc cgaaggtagc gcaccaggta cttctactga accgtctgaa 780 ggtagcgcac caggtacttc tgaaagcgca accccggaat ccggcccagg tacctctgaa 840 agcgcaaccc cggagtccgg cccaggtagc cctgctggct ctccaacctc caccgaagaa 900 ggtacctctg aaagcgcaac ccctgaatcc ggcccaggta gcgaaccggc aacctccggt 960 tctgaaaccc caggtacctc tgaaagcgct actccggagt ctggcccagg tacctctact 1020 gaaccgtctg agggtagcgc tccaggtact tctactgaac cgtccgaagg tagcgcacca 1080 ggtacttcta ccgaaccgtc cgaaggcagc gctccaggta cctctactga accttccgag 1140 ggcagcgctc caggtacctc taccgaacct tctgaaggta gcgcaccagg tacttctacc 1200 gaaccgtccg agggtagcgc accaggtagc ccagcaggtt ctcctacctc caccgaggaa 1260 ggtacttcta ccgaaccgtc cgagggtagc gcaccaggta cctctgaaag cgcaactcct 1320 gagtctggcc caggtagcga acctgctacc tccggctctg agactccagg tacctctgaa 1380 agcgcaaccc cggaatctgg tccaggtagc gaacctgcaa cctctggctc tgaaacccca 1440 ggtacctctg aaagcgctac tcctgaatct ggcccaggta cttctactga accgtccgag 1500 ggcagcgcac caggtacttc tgaaagcgct actcctgagt ccggcccagg tagcccggct 1560 ggctctccga cttccaccga ggaaggtagc ccggctggct ctccaacttc tactgaagaa 1620 ggtagcccgg caggctctcc gacctctact gaggaaggta cttctgaaag cgcaaccccg 1680 gagtccggcc caggtacctc taccgaaccg tctgagggca gcgcaccagg tacctctgaa 1740 agcgcaactc ctgagtctgg cccaggtagc gaacctgcta cctccggctc tgagactcca 1800 ggtacctctg aaagcgcaac cccggaatct ggtccaggta gcgaacctgc aacctctggc 1860 tctgaaaccc caggtacctc tgaaagcgct actcctgaat ctggcccagg tacttctact 1920 gaaccgtccg agggcagcgc accaggtagc cctgctggct ctccaacctc caccgaagaa 1980 ggtacctctg aaagcgcaac ccctgaatcc ggcccaggta gcgaaccggc aacctccggt 2040 tctgaaaccc caggtacttc tgaaagcgct actcctgagt ccggcccagg tagcccggct 2100 ggctctccga cttccaccga ggaaggtagc ccggctggct ctccaacttc tactgaagaa 2160 ggtacttcta ccgaaccttc cgagggcagc gcaccaggta cttctgaaag cgctacccct 2220 gagtccggcc caggtacttc tgaaagcgct actcctgaat ccggtccagg tacttctgaa 2280 agcgctaccc cggaatctgg cccaggtagc gaaccggcta cttctggttc tgaaacccca 2340 ggtagcgaac cggctacctc cggttctgaa actccaggta gcccagcagg ctctccgact 2400 tccactgagg aaggtacttc tactgaacct tccgaaggca gcgcaccagg tacctctact 2460 gaaccttctg agggcagcgc tccaggtagc gaacctgcaa cctctggctc tgaaacccca 2520 ggtacctctg aaagcgctac tcctgaatct ggcccaggta cttctactga accgtccgag 2580 ggcagcgcac ca 2592 <![CDATA[<210> 254]]> <![CDATA[<211> 2624]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> misc_feature]]> <![CDATA[<222> (1287)..(1298)]]> <![CDATA[<223> N可為核苷酸]]> <![CDATA[<220>]]> <![CDATA[<221> misc_feature]]> <![CDATA[<222> (1329)..(1337)]]> <![CDATA[<223> N可為核苷酸]]> <![CDATA[<400> 254]]> ggttctacca gcgaatctcc ttctggcacc gctccaggta cctctcctag cggcgaatct 60 tctaccgctc caggttctac tagcgaatct ccttctggca ctgcaccagg ttctactagc 120 gaatccccgt ctggtactgc tccaggtact tctactcctg aaagcggttc cgcttctcca 180 ggtacctcta ctccggaaag cggttctgca tctccaggtt ctaccagcga atctccttct 240 ggcaccgctc caggttctac tagcgaatcc ccgtctggta ccgcaccagg tacttctcct 300 agcggcgaat cttctaccgc accaggttct actagcgaat ctccgtctgg cactgctcca 360 ggtacttctc ctagcggtga atcttctacc gctccaggta cttcccctag cggcgaatct 420 tctaccgctc caggttctac tagctctact gcagaatctc cgggcccagg tacctctcct 480 agcggtgaat cttctaccgc tccaggtact tctccgagcg gtgaatcttc taccgctcca 540 ggttctacta gctctactgc agaatctcct ggcccaggta cctctactcc ggaaagcggc 600 tctgcatctc caggtacttc tacccctgaa agcggttctg catctccagg ttctactagc 660 gaatctcctt ctggcactgc accaggttct accagcgaat ctccgtctgg cactgcacca 720 ggtacctcta cccctgaaag cggttccgct tctccaggtt ctaccagctc taccgcagaa 780 tctcctggtc caggtacctc tactccggaa agcggctctg catctccagg ttctactagc 840 gaatctcctt ctggcactgc accaggtact tctccgagcg gtgaatcttc taccgcacca 900 ggttctacta gctctaccgc tgaatctccg ggcccaggta cttctccgag cggtgaatct 960 tctactgctc caggtacctc tactcctgaa agcggttctg catctccagg ttccactagc 1020 tctaccgcag aatctccggg cccaggttct actagctcta ctgctgaatc tcctggccca 1080 ggttctacta gctctactgc tgaatctccg ggtccaggtt ctaccagctc tactgctgaa 1140 tctcctggtc caggtacctc cccgagcggt gaatcttcta ctgcaccagg ttctactagc 1200 gaatctcctt ctggcactgc accaggttct accagcgaat ctccgtctgg cactgcacca 1260 ggtacctcta cccctgaaag cggtccnnnn nnnnnnntgc aagcgcaagc ggcgcgccaa 1320 gcacgggann nnnnnntagc gaatctcctt ctggtaccgc tccaggttct accagcgaat 1380 ccccgtctgg tactgctcca ggttctacca gcgaatctcc ttctggtact gcaccaggtt 1440 ctactagcga atctccttct ggtaccgctc caggttctac cagcgaatcc ccgtctggta 1500 ctgctccagg ttctaccagc gaatctcctt ctggtactgc accaggtact tctactccgg 1560 aaagcggttc cgcatctcca ggtacttctc ctagcggtga atcttctact gctccaggta 1620 cctctcctag cggcgaatct tctactgctc caggttctac cagctctact gctgaatctc 1680 cgggtccagg tacttccccg agcggtgaat cttctactgc accaggtact tctactccgg 1740 aaagcggttc cgcttctcca ggttctacca gcgaatctcc ttctggcacc gctccaggtt 1800 ctactagcga atccccgtct ggtaccgcac caggtacttc tcctagcggc gaatcttcta 1860 ccgcaccagg ttctactagc gaatccccgt ctggtaccgc accaggtact tctaccccgg 1920 aaagcggctc tgcttctcca ggtacttcta ccccggaaag cggctccgca tctccaggtt 1980 ctactagcga atctccttct ggtaccgctc caggtacttc tacccctgaa agcggctccg 2040 cttctccagg ttccactagc tctaccgctg aatctccggg tccaggttct accagcgaat 2100 ctccttctgg caccgctcca ggttctacta gcgaatcccc gtctggtacc gcaccaggta 2160 cttctcctag cggcgaatct tctaccgcac caggttctac cagctctact gctgaatctc 2220 cgggtccagg tacttccccg agcggtgaat cttctactgc accaggtact tctactccgg 2280 aaagcggttc cgcttctcca ggtacctccc ctagcggcga atcttctact gctccaggta 2340 cctctcctag cggcgaatct tctaccgctc caggtacctc ccctagcggt gaatcttcta 2400 ccgcaccagg ttctactagc tctactgctg aatctccggg tccaggttct accagctcta 2460 ctgctgaatc tcctggtcca ggtacctccc cgagcggtga atcttctact gcaccaggtt 2520 ctagcccttc tgcttccacc ggtaccggcc caggtagctc tactccgtct ggtgcaactg 2580 gctctccagg tagctctact ccgtctggtg caaccggctc ccca 2624 <![CDATA[<210> 255]]> <![CDATA[<211> 2592]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 255]]> ggtgcttccc cgggcaccag ctctactggt tctccaggtt ctagcccgtc tgcttctact 60 ggtactggtc caggttctag cccttctgct tccactggta ctggtccagg taccccgggt 120 agcggtaccg cttcttcttc tccaggtagc tctactccgt ctggtgctac cggctctcca 180 ggttctaacc cttctgcatc caccggtacc ggcccaggtg cttctccggg caccagctct 240 actggttctc caggtacccc gggcagcggt accgcatctt cttctccagg tagctctact 300 ccttctggtg caactggttc tccaggtact cctggcagcg gtaccgcttc ttcttctcca 360 ggtgcttctc ctggtactag ctctactggt tctccaggtg cttctccggg cactagctct 420 actggttctc caggtacccc gggtagcggt actgcttctt cctctccagg tagctctacc 480 ccttctggtg caaccggctc tccaggtgct tctccgggca ccagctctac cggttctcca 540 ggtaccccgg gtagcggtac cgcttcttct tctccaggta gctctactcc gtctggtgct 600 accggctctc caggttctaa cccttctgca tccaccggta ccggcccagg ttctagccct 660 tctgcttcca ccggtactgg cccaggtagc tctacccctt ctggtgctac cggctcccca 720 ggtagctcta ctccttctgg tgcaactggc tctccaggtg catctccggg cactagctct 780 actggttctc caggtgcatc ccctggcact agctctactg gttctccagg tgcttctcct 840 ggtaccagct ctactggttc tccaggtact cctggcagcg gtaccgcttc ttcttctcca 900 ggtgcttctc ctggtactag ctctactggt tctccaggtg cttctccggg cactagctct 960 actggttctc caggtgcttc cccgggcact agctctaccg gttctccagg ttctagccct 1020 tctgcatcta ctggtactgg cccaggtact ccgggcagcg gtactgcttc ttcctctcca 1080 ggtgcatctc cgggcactag ctctactggt tctccaggtg catcccctgg cactagctct 1140 actggttctc caggtgcttc tcctggtacc agctctactg gttctccagg tagctctact 1200 ccgtctggtg caaccggttc cccaggtagc tctactcctt ctggtgctac tggctcccca 1260 ggtgcatccc ctggcaccag ctctaccggt tctccaggta ccccgggcag cggtaccgca 1320 tcttcctctc caggtagctc taccccgtct ggtgctaccg gttccccagg tagctctacc 1380 ccgtctggtg caaccggctc cccaggtagc tctactccgt ctggtgcaac cggctcccca 1440 ggttctagcc cgtctgcttc cactggtact ggcccaggtg cttccccggg caccagctct 1500 actggttctc caggtgcatc cccgggtacc agctctaccg gttctccagg tactcctggc 1560 agcggtactg catcttcctc tccaggtgct tctccgggca ccagctctac tggttctcca 1620 ggtgcatctc cgggcactag ctctactggt tctccaggtg catcccctgg cactagctct 1680 actggttctc caggtgcttc tcctggtacc agctctactg gttctccagg tacccctggt 1740 agcggtactg cttcttcctc tccaggtagc tctactccgt ctggtgctac cggttctcca 1800 ggtaccccgg gtagcggtac cgcatcttct tctccaggta gctctacccc gtctggtgct 1860 actggttctc caggtactcc gggcagcggt actgcttctt cctctccagg tagctctacc 1920 ccttctggtg ctactggctc tccaggtagc tctaccccgt ctggtgctac tggctcccca 1980 ggttctagcc cttctgcatc caccggtacc ggtccaggtt ctagcccgtc tgcatctact 2040 ggtactggtc caggtgcatc cccgggcact agctctaccg gttctccagg tactcctggt 2100 agcggtactg cttcttcttc tccaggtagc tctactcctt ctggtgctac tggttctcca 2160 ggttctagcc cttctgcatc caccggtacc ggcccaggtt ctagcccgtc tgcttctacc 2220 ggtactggtc caggtgcttc tccgggtact agctctactg gttctccagg tgcatctcct 2280 ggtactagct ctactggttc tccaggtagc tctactccgt ctggtgcaac cggctctcca 2340 ggttctagcc cttctgcatc taccggtact ggtccaggtg catcccctgg taccagctct 2400 accggttctc caggttctag cccttctgct tctaccggta ccggtccagg tacccctggc 2460 agcggtaccg catcttcctc tccaggtagc tctactccgt ctggtgcaac cggttcccca 2520 ggtagctcta ctccttctgg tgctactggc tccccaggtg catcccctgg caccagctct 2580 accggttctc ca 2592 <![CDATA[<210> 256]]> <![CDATA[<211> 2772]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 256]]> atggctgaac ctgctggctc tccaacctcc actgaggaag gtgcatcccc gggcaccagc 60 tctaccggtt ctccaggtag ctctaccccg tctggtgcta ccggctctcc aggtagctct 120 accccgtctg gtgctactgg ctctccaggt acttctactg aaccgtctga aggcagcgca 180 ccaggtagcg aaccggctac ttccggttct gaaaccccag gtagcccagc aggttctcca 240 acttctactg aagaaggttc taccagctct accgcagaat ctcctggtcc aggtacctct 300 actccggaaa gcggctctgc atctccaggt tctactagcg aatctccttc tggcactgca 360 ccaggttcta ctagcgaatc cccgtctggt actgctccag gtacttctac tcctgaaagc 420 ggttccgctt ctccaggtac ctctactccg gaaagcggtt ctgcatctcc aggtagcgaa 480 ccggcaacct ccggctctga aaccccaggt acctctgaaa gcgctactcc tgaatccggc 540 ccaggtagcc cggcaggttc tccgacttcc actgaggaag gtacctctac tgaaccttct 600 gagggcagcg ctccaggtac ttctgaaagc gctaccccgg agtccggtcc aggtacttct 660 actgaaccgt ccgaaggtag cgcaccaggt acttctaccg aaccgtccga gggtagcgca 720 ccaggtagcc cagcaggttc tcctacctcc accgaggaag gtacttctac cgaaccgtcc 780 gagggtagcg caccaggtac ttctaccgaa ccttccgagg gcagcgcacc aggtacttct 840 gaaagcgcta cccctgagtc cggcccaggt acttctgaaa gcgctactcc tgaatccggt 900 ccaggtacct ctactgaacc ttccgaaggc agcgctccag gtacctctac cgaaccgtcc 960 gagggcagcg caccaggtac ttctgaaagc gcaacccctg aatccggtcc aggtacttct 1020 actgaacctt ccgaaggtag cgctccaggt agcgaacctg ctacttctgg ttctgaaacc 1080 ccaggtagcc cggctggctc tccgacctcc accgaggaag gtagctctac cccgtctggt 1140 gctactggtt ctccaggtac tccgggcagc ggtactgctt cttcctctcc aggtagctct 1200 accccttctg gtgctactgg ctctccaggt acctctaccg aaccgtccga gggtagcgca 1260 ccaggtacct ctactgaacc gtctgagggt agcgctccag gtagcgaacc ggcaacctcc 1320 ggttctgaaa ctccaggtag ccctgctggc tctccgactt ctactgagga aggtagcccg 1380 gctggttctc cgacttctac tgaggaaggt acttctaccg aaccttccga aggtagcgct 1440 ccaggtgcaa gcgcaagcgg cgcgccaagc acgggaggta cttctgaaag cgctactcct 1500 gagtccggcc caggtagccc ggctggctct ccgacttcca ccgaggaagg tagcccggct 1560 ggctctccaa cttctactga agaaggttct accagctcta ccgctgaatc tcctggccca 1620 ggttctacta gcgaatctcc gtctggcacc gcaccaggta cttcccctag cggtgaatct 1680 tctactgcac caggtacccc tggcagcggt accgcttctt cctctccagg tagctctacc 1740 ccgtctggtg ctactggctc tccaggttct agcccgtctg catctaccgg taccggccca 1800 ggtagcgaac cggcaacctc cggctctgaa actccaggta cttctgaaag cgctactccg 1860 gaatccggcc caggtagcga accggctact tccggctctg aaaccccagg ttccaccagc 1920 tctactgcag aatctccggg cccaggttct actagctcta ctgcagaatc tccgggtcca 1980 ggtacttctc ctagcggcga atcttctacc gctccaggta gcgaaccggc aacctctggc 2040 tctgaaactc caggtagcga acctgcaacc tccggctctg aaaccccagg tacttctact 2100 gaaccttctg agggcagcgc accaggttct accagctcta ccgcagaatc tcctggtcca 2160 ggtacctcta ctccggaaag cggctctgca tctccaggtt ctactagcga atctccttct 2220 ggcactgcac caggtacttc taccgaaccg tccgaaggca gcgctccagg tacctctact 2280 gaaccttccg agggcagcgc tccaggtacc tctaccgaac cttctgaagg tagcgcacca 2340 ggtagctcta ctccgtctgg tgcaaccggc tccccaggtt ctagcccgtc tgcttccact 2400 ggtactggcc caggtgcttc cccgggcacc agctctactg gttctccagg tagcgaacct 2460 gctacctccg gttctgaaac cccaggtacc tctgaaagcg caactccgga gtctggtcca 2520 ggtagccctg caggttctcc tacctccact gaggaaggta gctctactcc gtctggtgca 2580 accggctccc caggttctag cccgtctgct tccactggta ctggcccagg tgcttccccg 2640 ggcaccagct ctactggttc tccaggtacc tctgaaagcg ctactccgga gtctggccca 2700 ggtacctcta ctgaaccgtc tgagggtagc gctccaggta cttctactga accgtccgaa 2760 ggtagcgcac ca 2772 <![CDATA[<210> 257]]> <![CDATA[<211> 2739]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 257]]> atggctgaac ctgctggctc tccaacctcc actgaggaag gtaccccggg tagcggtact 60 gcttcttcct ctccaggtag ctctacccct tctggtgcaa ccggctctcc aggtgcttct 120 ccgggcacca gctctaccgg ttctccaggt agcccggctg gctctcctac ctctactgag 180 gaaggtactt ctgaaagcgc tactcctgag tctggtccag gtacctctac tgaaccgtcc 240 gaaggtagcg ctccaggtag cccagcaggc tctccgactt ccactgagga aggtacttct 300 actgaacctt ccgaaggcag cgcaccaggt acctctactg aaccttctga gggcagcgct 360 ccaggtactt ctgaaagcgc taccccggaa tctggcccag gtagcgaacc ggctacttct 420 ggttctgaaa ccccaggtag cgaaccggct acctccggtt ctgaaactcc aggtagcccg 480 gcaggctctc cgacctctac tgaggaaggt acttctgaaa gcgcaacccc ggagtccggc 540 ccaggtacct ctaccgaacc gtctgagggc agcgcaccag gtacttctac cgaaccgtcc 600 gagggtagcg caccaggtag cccagcaggt tctcctacct ccaccgagga aggtacttct 660 accgaaccgt ccgagggtag cgcaccaggt acctctactg aaccttctga gggcagcgct 720 ccaggtactt ctgaaagcgc taccccggag tccggtccag gtacttctac tgaaccgtcc 780 gaaggtagcg caccaggtac ttctgaaagc gcaacccctg aatccggtcc aggtagcgaa 840 ccggctactt ctggctctga gactccaggt acttctaccg aaccgtccga aggtagcgca 900 ccaggtactt ctactgaacc gtctgaaggt agcgcaccag gtacttctga aagcgcaacc 960 ccggaatccg gcccaggtac ctctgaaagc gcaaccccgg agtccggccc aggtagccct 1020 gctggctctc caacctccac cgaagaaggt acctctgaaa gcgcaacccc tgaatccggc 1080 ccaggtagcg aaccggcaac ctccggttct gaaaccccag gtacctctga aagcgctact 1140 ccggagtctg gcccaggtac ctctactgaa ccgtctgagg gtagcgctcc aggtacttct 1200 actgaaccgt ccgaaggtag cgcaccaggt acttctaccg aaccgtccga aggcagcgct 1260 ccaggtacct ctactgaacc ttccgagggc agcgctccag gtacctctac cgaaccttct 1320 gaaggtagcg caccaggtac ttctaccgaa ccgtccgagg gtagcgcacc aggtagccca 1380 gcaggttctc ctacctccac cgaggaaggt acttctaccg aaccgtccga gggtagcgca 1440 ccaggtacct ctgaaagcgc aactcctgag tctggcccag gtagcgaacc tgctacctcc 1500 ggctctgaga ctccaggtac ctctgaaagc gcaaccccgg aatctggtcc aggtagcgaa 1560 cctgcaacct ctggctctga aaccccaggt acctctgaaa gcgctactcc tgaatctggc 1620 ccaggtactt ctactgaacc gtccgagggc agcgcaccag gtacttctga aagcgctact 1680 cctgagtccg gcccaggtag cccggctggc tctccgactt ccaccgagga aggtagcccg 1740 gctggctctc caacttctac tgaagaaggt agcccggcag gctctccgac ctctactgag 1800 gaaggtactt ctgaaagcgc aaccccggag tccggcccag gtacctctac cgaaccgtct 1860 gagggcagcg caccaggtac ctctgaaagc gcaactcctg agtctggccc aggtagcgaa 1920 cctgctacct ccggctctga gactccaggt acctctgaaa gcgcaacccc ggaatctggt 1980 ccaggtagcg aacctgcaac ctctggctct gaaaccccag gtacctctga aagcgctact 2040 cctgaatctg gcccaggtac ttctactgaa ccgtccgagg gcagcgcacc aggtagccct 2100 gctggctctc caacctccac cgaagaaggt acctctgaaa gcgcaacccc tgaatccggc 2160 ccaggtagcg aaccggcaac ctccggttct gaaaccccag gtacttctga aagcgctact 2220 cctgagtccg gcccaggtag cccggctggc tctccgactt ccaccgagga aggtagcccg 2280 gctggctctc caacttctac tgaagaaggt acttctaccg aaccttccga gggcagcgca 2340 ccaggtactt ctgaaagcgc tacccctgag tccggcccag gtacttctga aagcgctact 2400 cctgaatccg gtccaggtac ttctgaaagc gctaccccgg aatctggccc aggtagcgaa 2460 ccggctactt ctggttctga aaccccaggt agcgaaccgg ctacctccgg ttctgaaact 2520 ccaggtagcc cagcaggctc tccgacttcc actgaggaag gtacttctac tgaaccttcc 2580 gaaggcagcg caccaggtac ctctactgaa ccttctgagg gcagcgctcc aggtagcgaa 2640 cctgcaacct ctggctctga aaccccaggt acctctgaaa gcgctactcc tgaatctggc 2700 ccaggtactt ctactgaacc gtccgagggc agcgcacca 2739 <![CDATA[<210> 258]]> <![CDATA[<211> 3954]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 258]]> ggtacttcta ctgaaccgtc tgaaggcagc gcaccaggta gcgaaccggc tacttccggt 60 tctgaaaccc caggtagccc agcaggttct ccaacttcta ctgaagaagg ttctaccagc 120 tctaccgcag aatctcctgg tccaggtacc tctactccgg aaagcggctc tgcatctcca 180 ggttctacta gcgaatctcc ttctggcact gcaccaggtt ctactagcga atccccgtct 240 ggtactgctc caggtacttc tactcctgaa agcggttccg cttctccagg tacctctact 300 ccggaaagcg gttctgcatc tccaggtagc gaaccggcaa cctccggctc tgaaacccca 360 ggtacctctg aaagcgctac tcctgaatcc ggcccaggta gcccggcagg ttctccgact 420 tccactgagg aaggtacctc tactgaacct tctgagggca gcgctccagg tacttctgaa 480 agcgctaccc cggagtccgg tccaggtact tctactgaac cgtccgaagg tagcgcacca 540 ggtacttcta ccgaaccgtc cgagggtagc gcaccaggta gcccagcagg ttctcctacc 600 tccaccgagg aaggtacttc taccgaaccg tccgagggta gcgcaccagg tacttctacc 660 gaaccttccg agggcagcgc accaggtact tctgaaagcg ctacccctga gtccggccca 720 ggtacttctg aaagcgctac tcctgaatcc ggtccaggta cctctactga accttccgaa 780 ggcagcgctc caggtacctc taccgaaccg tccgagggca gcgcaccagg tacttctgaa 840 agcgcaaccc ctgaatccgg tccaggtact tctactgaac cttccgaagg tagcgctcca 900 ggtagcgaac ctgctacttc tggttctgaa accccaggta gcccggctgg ctctccgacc 960 tccaccgagg aaggtagctc taccccgtct ggtgctactg gttctccagg tactccgggc 1020 agcggtactg cttcttcctc tccaggtagc tctacccctt ctggtgctac tggctctcca 1080 ggtacctcta ccgaaccgtc cgagggtagc gcaccaggta cctctactga accgtctgag 1140 ggtagcgctc caggtagcga accggcaacc tccggttctg aaactccagg tagccctgct 1200 ggctctccga cttctactga ggaaggtagc ccggctggtt ctccgacttc tactgaggaa 1260 ggtacttcta ccgaaccttc cgaaggtagc gctccaggtc cagaaccaac ggggccggcc 1320 ccaagcggag gtagcgaacc ggcaacctcc ggctctgaaa ccccaggtac ctctgaaagc 1380 gctactcctg aatccggccc aggtagcccg gcaggttctc cgacttccac tgaggaaggt 1440 acttctgaaa gcgctactcc tgagtccggc ccaggtagcc cggctggctc tccgacttcc 1500 accgaggaag gtagcccggc tggctctcca acttctactg aagaaggtac ttctgaaagc 1560 gctactcctg agtccggccc aggtagcccg gctggctctc cgacttccac cgaggaaggt 1620 agcccggctg gctctccaac ttctactgaa gaaggttcta ccagctctac cgctgaatct 1680 cctggcccag gttctactag cgaatctccg tctggcaccg caccaggtac ttcccctagc 1740 ggtgaatctt ctactgcacc aggttctacc agcgaatctc cttctggcac cgctccaggt 1800 tctactagcg aatccccgtc tggtaccgca ccaggtactt ctcctagcgg cgaatcttct 1860 accgcaccag gtacttctac cgaaccttcc gagggcagcg caccaggtac ttctgaaagc 1920 gctacccctg agtccggccc aggtacttct gaaagcgcta ctcctgaatc cggtccaggt 1980 agcgaaccgg caacctctgg ctctgaaacc ccaggtacct ctgaaagcgc tactccggaa 2040 tctggtccag gtacttctga aagcgctact ccggaatccg gtccaggtac ctctactgaa 2100 ccttctgagg gcagcgctcc aggtacttct gaaagcgcta ccccggagtc cggtccaggt 2160 acttctactg aaccgtccga aggtagcgca ccaggtacct cccctagcgg cgaatcttct 2220 actgctccag gtacctctcc tagcggcgaa tcttctaccg ctccaggtac ctcccctagc 2280 ggtgaatctt ctaccgcacc aggtacttct accgaaccgt ccgagggtag cgcaccaggt 2340 agcccagcag gttctcctac ctccaccgag gaaggtactt ctaccgaacc gtccgagggt 2400 agcgcaccag gttctagccc ttctgcttcc accggtaccg gcccaggtag ctctactccg 2460 tctggtgcaa ctggctctcc aggtagctct actccgtctg gtgcaaccgg ctccccaggt 2520 agctctaccc cgtctggtgc taccggctct ccaggtagct ctaccccgtc tggtgcaacc 2580 ggctccccag gtgcatcccc gggtactagc tctaccggtt ctccaggtgc aagcgcaagc 2640 ggcgcgccaa gcacgggagg tacttctccg agcggtgaat cttctaccgc accaggttct 2700 actagctcta ccgctgaatc tccgggccca ggtacttctc cgagcggtga atcttctact 2760 gctccaggta cctctgaaag cgctactccg gagtctggcc caggtacctc tactgaaccg 2820 tctgagggta gcgctccagg tacttctact gaaccgtccg aaggtagcgc accaggttct 2880 agcccttctg catctactgg tactggccca ggtagctcta ctccttctgg tgctaccggc 2940 tctccaggtg cttctccggg tactagctct accggttctc caggtacttc tactccggaa 3000 agcggttccg catctccagg tacttctcct agcggtgaat cttctactgc tccaggtacc 3060 tctcctagcg gcgaatcttc tactgctcca ggtacttctg aaagcgcaac ccctgaatcc 3120 ggtccaggta gcgaaccggc tacttctggc tctgagactc caggtacttc taccgaaccg 3180 tccgaaggta gcgcaccagg ttctaccagc gaatcccctt ctggtactgc tccaggttct 3240 accagcgaat ccccttctgg caccgcacca ggtacttcta cccctgaaag cggctccgct 3300 tctccaggta gcccggcagg ctctccgacc tctactgagg aaggtacttc tgaaagcgca 3360 accccggagt ccggcccagg tacctctacc gaaccgtctg agggcagcgc accaggtagc 3420 cctgctggct ctccaacctc caccgaagaa ggtacctctg aaagcgcaac ccctgaatcc 3480 ggcccaggta gcgaaccggc aacctccggt tctgaaaccc caggtagctc taccccgtct 3540 ggtgctaccg gttccccagg tgcttctcct ggtactagct ctaccggttc tccaggtagc 3600 tctaccccgt ctggtgctac tggctctcca ggttctacta gcgaatcccc gtctggtact 3660 gctccaggta cttcccctag cggtgaatct tctactgctc caggttctac cagctctacc 3720 gcagaatctc cgggtccagg tagctctacc ccttctggtg caaccggctc tccaggtgca 3780 tccccgggta ccagctctac cggttctcca ggtactccgg gtagcggtac cgcttcttcc 3840 tctccaggta gccctgctgg ctctccgact tctactgagg aaggtagccc ggctggttct 3900 ccgacttcta ctgaggaagg tacttctacc gaaccttccg aaggtagcgc tcca 3954 <![CDATA[<210> 259]]> <![CDATA[<211> 2592]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 259]]> ggtacttcca ccgaaccatc cgaaccaggt agcgcaggta cttccaccga accatccgaa 60 cctggcagcg caggtagcga accggcaacc tctggtactg aaccatcagg tagcggcgca 120 tccgagccta cctctactga accaggtagc gaaccggcta cctccggtac tgagccatca 180 ggtagcgaac cggcaacttc cggtactgaa ccatcaggta gcgaaccggc aacttccggc 240 actgaaccat caggtagcgg tgcatctgag ccgacctcta ctgaaccagg tacttctact 300 gaaccatctg agccgggcag cgcaggtagc gaaccagcta cttctggcac tgaaccatca 360 ggtacttcta ctgaaccatc cgaaccaggt agcgcaggta gcgaacctgc tacctctggt 420 actgagccat caggtagcga accggctacc tctggtactg aaccatcagg tacttctacc 480 gaaccatccg agcctggtag cgcaggtact tctaccgaac catccgagcc aggcagcgca 540 ggtagcgaac cggcaacctc tggcactgag ccatcaggta gcgaaccagc aacttctggt 600 actgaaccat caggtactag cgagccatct acttccgaac caggtgcagg tagcggcgca 660 tccgaaccta cttccactga accaggtact agcgagccat ccacctctga accaggtgca 720 ggtagcgaac cggcaacttc cggcactgaa ccatcaggta gcgaaccggc tacctctggt 780 actgaaccat caggtacttc taccgaacca tccgagcctg gtagcgcagg tacttctacc 840 gaaccatccg agccaggcag cgcaggtagc ggtgcatccg agccgacctc tactgaacca 900 ggtagcgaac cagcaacttc tggcactgag ccatcaggta gcgaaccagc tacctctggt 960 actgaaccat caggtagcga accggctact tccggcactg aaccatcagg tagcgaacca 1020 gcaacctccg gtactgaacc atcaggtact tccactgaac catccgaacc gggtagcgca 1080 ggtagcgaac cggcaacttc cggcactgaa ccatcaggta gcggtgcatc tgagccgacc 1140 tctactgaac caggtacttc tactgaacca tctgagccgg gcagcgcagg tagcgaacct 1200 gcaacctccg gcactgagcc atcaggtagc ggcgcatctg aaccaacctc tactgaacca 1260 ggtacttcca ccgaaccatc tgagccaggc agcgcaggta gcggcgcatc tgaaccaacc 1320 tctactgaac caggtagcga accagcaact tctggtactg aaccatcagg tagcggcgca 1380 tctgagccta cttccactga accaggtagc gaaccggcaa cttccggcac tgaaccatca 1440 ggtagcggtg catctgagcc gacctctact gaaccaggta cttctactga accatctgag 1500 ccgggcagcg caggtagcga accggcaact tccggcactg aaccatcagg tagcggtgca 1560 tctgagccga cctctactga accaggtact tctactgaac catctgagcc gggcagcgca 1620 ggtagcgaac cagctacttc tggcactgaa ccatcaggta cttctactga accatccgaa 1680 ccaggtagcg caggtagcga acctgctacc tctggtactg agccatcagg tacttctact 1740 gaaccatccg agccgggtag cgcaggtact tccactgaac catctgaacc tggtagcgca 1800 ggtacttcca ctgaaccatc cgaaccaggt agcgcaggta cttctactga accatccgag 1860 ccgggtagcg caggtacttc cactgaacca tctgaacctg gtagcgcagg tacttccact 1920 gaaccatccg aaccaggtag cgcaggtact agcgaaccat ccacctccga accaggcgca 1980 ggtagcggtg catctgaacc gacttctact gaaccaggta cttccactga accatctgag 2040 ccaggtagcg caggtacttc caccgaacca tccgaaccag gtagcgcagg tacttccacc 2100 gaaccatccg aacctggcag cgcaggtagc gaaccggcaa cctctggtac tgaaccatca 2160 ggtagcggtg catccgagcc gacctctact gaaccaggta gcgaaccagc aacttctggc 2220 actgagccat caggtagcga accagctacc tctggtactg aaccatcagg tagcgaaccg 2280 gcaacctctg gcactgagcc atcaggtagc gaaccagcaa cttctggtac tgaaccatca 2340 ggtactagcg agccatctac ttccgaacca ggtgcaggta gcgaacctgc aacctccggc 2400 actgagccat caggtagcgg cgcatctgaa ccaacctcta ctgaaccagg tacttccacc 2460 gaaccatctg agccaggcag cgcaggtagc gaacctgcaa cctccggcac tgagccatca 2520 ggtagcggcg catctgaacc aacctctact gaaccaggta cttccaccga accatctgag 2580 ccaggcagcg ca 2592 <![CDATA[<210> 260]]> <![CDATA[<211> 2592]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 260]]> ggtagcgaaa ctgctacttc cggctctgag actgcaggta ctagtgaatc cgcaactagc 60 gaatctggcg caggtagcac tgcaggctct gagacttcca ctgaagcagg tactagcgag 120 tccgcaacca gcgaatccgg cgcaggtagc gaaactgcta cctctggctc cgagactgca 180 ggtagcgaaa ctgcaacctc tggctctgaa actgcaggta cttccactga agcaagtgaa 240 ggctccgcat caggtacttc caccgaagca agcgaaggct ccgcatcagg tactagtgag 300 tccgcaacta gcgaatccgg tgcaggtagc gaaaccgcta cctctggttc cgaaactgca 360 ggtacttcta ccgaggctag cgaaggttct gcatcaggta gcactgctgg ttccgagact 420 tctactgaag caggtactag cgaatctgct actagcgaat ccggcgcagg tactagcgaa 480 tccgctacca gcgaatccgg cgcaggtagc gaaactgcaa cctctggttc cgagactgca 540 ggtactagcg agtccgctac tagcgaatct ggcgcaggta cttccactga agctagtgaa 600 ggttctgcat caggtagcga aactgctact tctggttccg aaactgcagg tagcgaaacc 660 gctacctctg gttccgaaac tgcaggtact tctaccgagg ctagcgaagg ttctgcatca 720 ggtagcactg ctggttccga gacttctact gaagcaggta ctagcgagtc cgctactagc 780 gaatctggcg caggtacttc cactgaagct agtgaaggtt ctgcatcagg tagcgaaact 840 gctacttctg gttccgaaac tgcaggtagc actgctggct ccgagacttc taccgaagca 900 ggtagcactg caggttccga aacttccact gaagcaggta gcgaaactgc tacctctggc 960 tctgagactg caggtactag cgaatctgct actagcgaat ccggcgcagg tactagcgaa 1020 tccgctacca gcgaatccgg cgcaggtagc gaaactgcaa cctctggttc cgagactgca 1080 ggtactagcg aatctgctac tagcgaatcc ggcgcaggta ctagcgaatc cgctaccagc 1140 gaatccggcg caggtagcga aactgcaacc tctggttccg agactgcagg tagcgaaacc 1200 gctacctctg gttccgaaac tgcaggtact tctaccgagg ctagcgaagg ttctgcatca 1260 ggtagcactg ctggttccga gacttctact gaagcaggta gcgaaactgc tacttccggc 1320 tctgagactg caggtactag tgaatccgca actagcgaat ctggcgcagg tagcactgca 1380 ggctctgaga cttccactga agcaggtagc actgctggtt ccgaaacctc taccgaagca 1440 ggtagcactg caggttctga aacctccact gaagcaggta cttccactga ggctagtgaa 1500 ggctctgcat caggtagcac tgctggttcc gaaacctcta ccgaagcagg tagcactgca 1560 ggttctgaaa cctccactga agcaggtact tccactgagg ctagtgaagg ctctgcatca 1620 ggtagcactg caggttctga gacttccacc gaagcaggta gcgaaactgc tacttctggt 1680 tccgaaactg caggtacttc cactgaagct agtgaaggtt ccgcatcagg tactagtgag 1740 tccgcaacca gcgaatccgg cgcaggtagc gaaaccgcaa cctccggttc tgaaactgca 1800 ggtactagcg aatccgcaac cagcgaatct ggcgcaggta ctagtgagtc cgcaaccagc 1860 gaatccggcg caggtagcga aaccgcaacc tccggttctg aaactgcagg tactagcgaa 1920 tccgcaacca gcgaatctgg cgcaggtagc gaaactgcta cttccggctc tgagactgca 1980 ggtacttcca ccgaagcaag cgaaggttcc gcatcaggta cttccaccga ggctagtgaa 2040 ggctctgcat caggtagcac tgctggctcc gagacttcta ccgaagcagg tagcactgca 2100 ggttccgaaa cttccactga agcaggtagc gaaactgcta cctctggctc tgagactgca 2160 ggtactagcg aatctgctac tagcgaatcc ggcgcaggta ctagcgaatc cgctaccagc 2220 gaatccggcg caggtagcga aactgcaacc tctggttccg agactgcagg tagcgaaact 2280 gctacttccg gctccgagac tgcaggtagc gaaactgcta cttctggctc cgaaactgca 2340 ggtacttcta ctgaggctag tgaaggttcc gcatcaggta ctagcgagtc cgcaaccagc 2400 gaatccggcg caggtagcga aactgctacc tctggctccg agactgcagg tagcgaaact 2460 gcaacctctg gctctgaaac tgcaggtact agcgaatctg ctactagcga atccggcgca 2520 ggtactagcg aatccgctac cagcgaatcc ggcgcaggta gcgaaactgc aacctctggt 2580 tccgagactg ca 2592 <![CDATA[<210> 261]]> <![CDATA[<211> 37]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 261]]> aggtgcaagc gcaagcggcg cgccaagcac gggaggt 37 <![CDATA[<210> 262]]> <![CDATA[<211> 37]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 262]]> aggtccagaa ccaacggggc cggccccaag cggaggt 37 <![CDATA[<210> 263]]> <![CDATA[<211> 6]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 263]]> His His His His His His 1 5 <![CDATA[<210> 264]]> <![CDATA[<211> 4]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 264]]> Asp Asp Asp Lys 1 <![CDATA[<210> 265]]> <![CDATA[<211> 4]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 265]]> Ile Asp Gly Arg 1 <![CDATA[<210> 266]]> <![CDATA[<211> 6]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 266]]> Leu Val Pro Arg Gly Ser 1 5 <![CDATA[<210> 267]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 267]]> Leu Glu Val Leu Phe Gln Gly Pro 1 5 <![CDATA[<210> 268]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 268]]> Glu Gln Leu Tyr Phe Gln Gly 1 5 <![CDATA[<210> 269]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 269]]> Glu Thr Leu Phe Gln Gly Pro 1 5 <![CDATA[<210> 270]]> <![CDATA[<211> 4]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 270]]> Gly Gly Ser Gly 1 <![CDATA[<210> 271]]> <![CDATA[<211> 9]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 271]]> Phe Asp Lys Leu Pro Arg Thr Ser Gly 1 5 <![CDATA[<210> 272]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 272]]> Phe Lys Leu Met Val Trp Tyr 1 5 <![CDATA[<210> 273]]> <![CDATA[<211> 5]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 273]]> Gly Gly Gly Gly Ser 1 5 <![CDATA[<210> 274]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 274]]> Lys Leu Thr Arg Val Val Gly Gly 1 5 <![CDATA[<210> 275]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 275]]> Thr Met Thr Arg Ile Val Gly Gly 1 5 <![CDATA[<210> 276]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 276]]> Ser Pro Phe Arg Ser Thr Gly Gly 1 5 <![CDATA[<210> 277]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 277]]> Leu Gln Val Arg Ile Val Gly Gly 1 5 <![CDATA[<210> 278]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 278]]> Pro Leu Gly Arg Ile Val Gly Gly 1 5 <![CDATA[<210> 279]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 279]]> Ile Glu Gly Arg Thr Val Gly Gly 1 5 <![CDATA[<210> 280]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 280]]> Leu Thr Pro Arg Ser Leu Leu Val 1 5 <![CDATA[<210> 281]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 281]]> Leu Gly Pro Val Ser Gly Val Pro 1 5 <![CDATA[<210> 282]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 282]]> Val Ala Gly Asp Ser Leu Glu Glu 1 5 <![CDATA[<210> 283]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 283]]> Gly Pro Ala Gly Leu Gly Gly Ala 1 5 <![CDATA[<210> 284]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 284]]> Gly Pro Ala Gly Leu Arg Gly Ala 1 5 <![CDATA[<210> 285]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 285]]> Ala Pro Leu Gly Leu Arg Leu Arg 1 5 <![CDATA[<210> 286]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 286]]> Pro Ala Leu Pro Leu Val Ala Gln 1 5 <![CDATA[<210> 287]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 287]]> Glu Asn Leu Tyr Phe Gln Gly 1 5 <![CDATA[<210> 288]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 288]]> Asp Asp Asp Lys Ile Val Gly Gly 1 5 <![CDATA[<210> 289]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 289]]> Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 1 5 10 <![CDATA[<210> 290]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 290]]> Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 1 5 10 <![CDATA[<210> 291]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 291]]> Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 1 5 10 <![CDATA[<210> 292]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 292]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 1 5 10 <![CDATA[<210> 293]]> <![CDATA[<211> 24]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 293]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro 20 <![CDATA[<210> 294]]> <![CDATA[<211> 36]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 294]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro 35 <![CDATA[<210> 295]]> <![CDATA[<211> 48]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 295]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 <![CDATA[<210> 296]]> <![CDATA[<211> 60]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 296]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 50 55 60 <![CDATA[<210> 297]]> <![CDATA[<211> 108]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 297]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 100 105 <![CDATA[<210> 298]]> <![CDATA[<211> 216]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 298]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro 210 215 <![CDATA[<210> 299]]> <![CDATA[<211> 432]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 299]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 <![CDATA[<210> 300]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 300]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <![CDATA[<210> 301]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 301]]> Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 1 5 10 15 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 20 25 30 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 35 40 45 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 50 55 60 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 65 70 75 80 Glu Gly Gly Pro Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 85 90 95 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 100 105 110 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 115 120 125 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 130 135 140 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 145 150 155 160 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 165 170 175 Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 180 185 190 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 195 200 205 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 210 215 220 Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 225 230 235 240 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 245 250 255 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 260 265 270 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 275 280 285 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro 290 295 300 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 305 310 315 320 Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 325 330 335 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro 340 345 350 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser 355 360 365 Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 370 375 380 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 385 390 395 400 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 405 410 415 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 420 425 430 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 435 440 445 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 450 455 460 Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 465 470 475 480 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu 485 490 495 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 500 505 510 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 515 520 525 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Glu Gly 530 535 540 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 545 550 555 560 Glu Gly Gly Pro Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 565 570 575 <![CDATA[<210> 302]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 302]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 <![CDATA[<210> 303]]> <![CDATA[<211> 540]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 303]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 1 5 10 15 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 85 90 95 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 130 135 140 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 165 170 175 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 180 185 190 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 225 230 235 240 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 275 280 285 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 290 295 300 Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly 305 310 315 320 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 325 330 335 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 340 345 350 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 370 375 380 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 420 425 430 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 435 440 445 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 450 455 460 Ser Ala Ser Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 465 470 475 480 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 485 490 495 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 500 505 510 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 515 520 525 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 530 535 540 <![CDATA[<210> 304]]> <![CDATA[<211> 504]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 304]]> Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Asn Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 145 150 155 160 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 165 170 175 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 180 185 190 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Asn Pro 195 200 205 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 210 215 220 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 225 230 235 240 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 245 250 255 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 260 265 270 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 275 280 285 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 290 295 300 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 305 310 315 320 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 325 330 335 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 340 345 350 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 355 360 365 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 370 375 380 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 385 390 395 400 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 405 410 415 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 420 425 430 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 435 440 445 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 450 455 460 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 465 470 475 480 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 485 490 495 Gly Thr Ser Ser Thr Gly Ser Pro 500 <![CDATA[<210> 305]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 305]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <![CDATA[<210> 306]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (430)..(432)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (443)..(446)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 306]]> Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 1 5 10 15 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 85 90 95 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 130 135 140 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 165 170 175 Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 180 185 190 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 225 230 235 240 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 275 280 285 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 290 295 300 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser 305 310 315 320 Ser Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 325 330 335 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 340 345 350 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 370 375 380 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Pro Xaa Xaa Xaa 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Xaa Xaa Xaa Xaa Ser Glu 435 440 445 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 450 455 460 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 465 470 475 480 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 500 505 510 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 515 520 525 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 530 535 540 Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 565 570 575 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro 625 630 635 640 Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser 645 650 655 Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Ser 675 680 685 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 690 695 700 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 705 710 715 720 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser 725 730 735 Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 755 760 765 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 770 775 780 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 785 790 795 800 Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 805 810 815 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser 820 825 830 Gly Glu Ser Ser Thr Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 835 840 845 Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 865 870 875 <![CDATA[<210> 307]]> <![CDATA[<211> 868]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 307]]> Gly Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 1 5 10 15 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 20 25 30 Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 35 40 45 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 50 55 60 Gly Ser Asn Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 65 70 75 80 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 85 90 95 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 100 105 110 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 115 120 125 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 130 135 140 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 145 150 155 160 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 165 170 175 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 180 185 190 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 195 200 205 Gly Ser Asn Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 210 215 220 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala 225 230 235 240 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 245 250 255 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 260 265 270 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 275 280 285 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 290 295 300 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 305 310 315 320 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 325 330 335 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 340 345 350 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 355 360 365 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 370 375 380 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 385 390 395 400 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 405 410 415 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 420 425 430 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 435 440 445 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 450 455 460 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 465 470 475 480 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 485 490 495 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 500 505 510 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 515 520 525 Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 530 535 540 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 545 550 555 560 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 565 570 575 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 580 585 590 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 595 600 605 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 610 615 620 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 625 630 635 640 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 645 650 655 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 660 665 670 Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 675 680 685 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly 690 695 700 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 705 710 715 720 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 725 730 735 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 740 745 750 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 755 760 765 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 770 775 780 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 785 790 795 800 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 805 810 815 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 820 825 830 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 835 840 845 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 850 855 860 Thr Gly Ser Pro 865 <![CDATA[<210> 308]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 308]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu Ser 435 440 445 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 450 455 460 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 500 505 510 Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 515 520 525 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 530 535 540 Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 545 550 555 560 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 565 570 575 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser Ser 580 585 590 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 595 600 605 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 625 630 635 640 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 645 650 655 Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 675 680 685 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr Pro 725 730 735 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 740 745 750 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 755 760 765 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 770 775 780 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 785 790 795 800 Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 805 810 815 Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly 820 825 830 Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 835 840 845 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 850 855 860 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 865 870 875 <![CDATA[<210> 309]]> <![CDATA[<211> 1318]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 309]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Pro Glu Pro Thr Gly Pro Ala Pro Ser Gly Gly Ser Glu Pro Ala 435 440 445 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 450 455 460 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 485 490 495 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 500 505 510 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 515 520 525 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 530 535 540 Ser Pro Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 565 570 575 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 625 630 635 640 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 645 650 655 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 660 665 670 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 675 680 685 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Pro Ser 725 730 735 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 755 760 765 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 770 775 780 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 785 790 795 800 Ser Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly 805 810 815 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro 820 825 830 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr 835 840 845 Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Ala Ser 865 870 875 880 Gly Ala Pro Ser Thr Gly Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr 885 890 895 Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr 900 905 910 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala 915 920 925 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 930 935 940 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 945 950 955 960 Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser 965 970 975 Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly 980 985 990 Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr 995 1000 1005 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 1010 1015 1020 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1025 1030 1035 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1040 1045 1050 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 1055 1060 1065 Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 1070 1075 1080 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 1085 1090 1095 Ser Ala Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1100 1105 1110 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1115 1120 1125 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1130 1135 1140 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 1145 1150 1155 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1160 1165 1170 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala 1175 1180 1185 Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro 1190 1195 1200 Ser Gly Ala Thr Gly Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 1205 1210 1215 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala 1220 1225 1230 Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser 1235 1240 1245 Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly 1250 1255 1260 Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 1265 1270 1275 Ser Ser Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1280 1285 1290 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1295 1300 1305 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1310 1315 <![CDATA[<210> 310]]> <![CDATA[<211> 924]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 310]]> Met Ala Glu Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ala Ser 1 5 10 15 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly 20 25 30 Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 35 40 45 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 50 55 60 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 65 70 75 80 Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly 85 90 95 Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr 100 105 110 Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro 115 120 125 Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser 130 135 140 Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu 145 150 155 160 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 180 185 190 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 210 215 220 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 225 230 235 240 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 290 295 300 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 305 310 315 320 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 340 345 350 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 355 360 365 Thr Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 370 375 380 Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser 385 390 395 400 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser 405 410 415 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 435 440 445 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 450 455 460 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 465 470 475 480 Pro Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu 485 490 495 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 500 505 510 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 530 535 540 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 545 550 555 560 Ser Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 565 570 575 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro 580 585 590 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 595 600 605 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 610 615 620 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser 625 630 635 640 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu 645 650 655 Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 675 680 685 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu 690 695 700 Gly Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 705 710 715 720 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 725 730 735 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 740 745 750 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 755 760 765 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr 770 775 780 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 785 790 795 800 Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 805 810 815 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 820 825 830 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 835 840 845 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 850 855 860 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 865 870 875 880 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro 885 890 895 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 900 905 910 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 915 920 <![CDATA[<210> 311]]> <![CDATA[<211> 913]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 311]]> Met Ala Glu Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Pro 1 5 10 15 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 20 25 30 Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 35 40 45 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 65 70 75 80 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 85 90 95 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 100 105 110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 195 200 205 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 210 215 220 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 225 230 235 240 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 275 280 285 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 290 295 300 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 305 310 315 320 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 340 345 350 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 355 360 365 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 405 410 415 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 435 440 445 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 450 455 460 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 485 490 495 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 515 520 525 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 530 535 540 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 565 570 575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 580 585 590 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 625 630 635 640 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 645 650 655 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 660 665 670 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 675 680 685 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 705 710 715 720 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 740 745 750 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 755 760 765 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 770 775 780 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 785 790 795 800 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 805 810 815 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 820 825 830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 835 840 845 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 850 855 860 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 865 870 875 880 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 885 890 895 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 900 905 910 Pro <![CDATA[<210> 312]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 312]]> Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 1 5 10 15 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 35 40 45 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro 50 55 60 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 65 70 75 80 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 85 90 95 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 115 120 125 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 130 135 140 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr 145 150 155 160 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 180 185 190 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Glu 195 200 205 Pro Ser Thr Ser Glu Pro Gly Ala Gly Ser Gly Ala Ser Glu Pro Thr 210 215 220 Ser Thr Glu Pro Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 225 230 235 240 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro 245 250 255 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 275 280 285 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 325 330 335 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 355 360 365 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 385 390 395 400 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 405 410 415 Ser Thr Glu Pro Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 420 425 430 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 450 455 460 Ser Thr Glu Pro Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 465 470 475 480 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly 500 505 510 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 515 520 525 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 530 535 540 Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Thr Glu Pro Ser Glu 545 550 555 560 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 565 570 575 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 580 585 590 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 595 600 605 Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 610 615 620 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Glu Pro Ser Thr Ser 645 650 655 Glu Pro Gly Ala Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 660 665 670 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr 675 680 685 Glu Pro Ser Glu Pro Gly Ser Ala Gly Thr Ser Thr Glu Pro Ser Glu 690 695 700 Pro Gly Ser Ala Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 705 710 715 720 Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro Gly Ser Glu Pro 725 730 735 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly 740 745 750 Thr Glu Pro Ser Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser Gly Thr Ser Glu 770 775 780 Pro Ser Thr Ser Glu Pro Gly Ala Gly Ser Glu Pro Ala Thr Ser Gly 785 790 795 800 Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Thr Glu Pro Ser Gly Ser Gly Ala Ser Glu Pro Thr 835 840 845 Ser Thr Glu Pro Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 850 855 860 <![CDATA[<210> 313]]> <![CDATA[<211> 84]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 313]]> Ala Ser Pro Ala Ala Pro Ala Pro Ala Ser Pro Ala Ala Pro Ala Pro 1 5 10 15 Ser Ala Pro Ala Ala Ala Pro Ala Ser Pro Ala Pro Ala Ala Pro Ser 20 25 30 Ala Pro Ala Pro Ala Ala Pro Ser Ala Ala Ser Pro Ala Ala Pro Ser 35 40 45 Ala Pro Pro Ala Ala Ala Ser Pro Ala Ala Pro Ser Ala Pro Pro Ala 50 55 60 Ala Ser Ala Ala Ala Pro Ala Ala Ala Ser Ala Ala Ala Ser Ala Pro 65 70 75 80 Ser Ala Ala Ala <![CDATA[<210> 314]]> <![CDATA[<211> 288]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 314]]> Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 1 5 10 15 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 20 25 30 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 35 40 45 Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 50 55 60 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 65 70 75 80 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 85 90 95 Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 100 105 110 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 115 120 125 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 130 135 140 Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 145 150 155 160 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 165 170 175 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 180 185 190 Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 195 200 205 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 210 215 220 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 225 230 235 240 Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly 245 250 255 Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser 260 265 270 Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly 275 280 285 <![CDATA[<210> 315]]> <![CDATA[<211> 288]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 315]]> Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly 1 5 10 15 Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly 20 25 30 Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly 35 40 45 Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly 50 55 60 Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu 65 70 75 80 Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly 85 90 95 Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu 100 105 110 Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu 115 120 125 Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly 130 135 140 Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly 145 150 155 160 Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly 165 170 175 Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly 180 185 190 Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly 195 200 205 Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu 210 215 220 Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly 225 230 235 240 Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu 245 250 255 Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly Gly Glu 260 265 270 Gly Glu Gly Gly Gly Glu Gly Gly Glu Gly Glu Gly Gly Gly Glu Gly 275 280 285 <![CDATA[<210> 316]]> <![CDATA[<211> 288]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 316]]> Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 1 5 10 15 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 20 25 30 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 35 40 45 Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 50 55 60 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 65 70 75 80 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 85 90 95 Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 100 105 110 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 115 120 125 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 130 135 140 Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 145 150 155 160 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 165 170 175 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 180 185 190 Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 195 200 205 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 210 215 220 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 225 230 235 240 Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser 245 250 255 Ser Glu Ser Ser Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser 260 265 270 Ser Ser Glu Ser Ser Ser Glu Ser Ser Glu Ser Ser Ser Ser Glu Ser 275 280 285 <![CDATA[<210> 317]]> <![CDATA[<211> 288]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 317]]> Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser 1 5 10 15 Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Gly Ser 20 25 30 Glu Gly Ser Glu Gly Glu Gly Gly Ser Glu Gly Ser Glu Gly Glu Gly 35 40 45 Gly Ser Glu Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly 50 55 60 Glu Gly Gly Ser Glu Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Ser 65 70 75 80 Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly Ser Glu 85 90 95 Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly 100 105 110 Glu Gly Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu 115 120 125 Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu 130 135 140 Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser 145 150 155 160 Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Gly Ser 165 170 175 Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly 180 185 190 Gly Glu Gly Ser Gly Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly 195 200 205 Glu Gly Gly Gly Glu Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Gly 210 215 220 Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly Ser Glu 225 230 235 240 Gly Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser 245 250 255 Glu Gly Gly Ser Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu 260 265 270 Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu 275 280 285 <![CDATA[<210> 318]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 318]]> Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Glu Gly Gly Gly Gly Lys 1 5 10 15 Pro Gly Gly Lys Pro Glu Gly Glu Gly Glu Gly Lys Pro Gly Gly Lys 20 25 30 Pro Glu Gly Gly Gly Lys Pro Gly Gly Gly Glu Gly Gly Lys Pro Glu 35 40 45 Gly Gly Lys Pro Glu Gly Glu Gly Lys Pro Gly Gly Gly Glu Gly Lys 50 55 60 Pro Gly Gly Lys Pro Glu Gly Gly Gly Gly Lys Pro Glu Gly Glu Gly 65 70 75 80 Lys Pro Gly Gly Gly Gly Gly Lys Pro Gly Gly Lys Pro Glu Gly Glu 85 90 95 Gly Lys Pro Gly Gly Gly Glu Gly Gly Lys Pro Glu Gly Lys Pro Gly 100 105 110 Glu Gly Gly Glu Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Gly Glu 115 120 125 Gly Lys Pro Gly Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Gly Glu 130 135 140 Gly Lys Pro Gly Gly Gly Glu Gly Gly Lys Pro Glu Gly Gly Lys Pro 145 150 155 160 Glu Gly Glu Gly Lys Pro Gly Gly Gly Glu Gly Lys Pro Gly Gly Lys 165 170 175 Pro Gly Glu Gly Gly Lys Pro Glu Gly Gly Gly Glu Gly Lys Pro Gly 180 185 190 Gly Lys Pro Gly Glu Gly Gly Glu Gly Lys Pro Gly Gly Gly Lys Pro 195 200 205 Glu Gly Glu Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Gly Glu Gly 210 215 220 Gly Lys Pro Glu Gly Glu Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly 225 230 235 240 Gly Glu Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Gly Lys Pro Glu 245 250 255 Gly Gly Gly Glu Gly Lys Pro Gly Gly Gly Lys Pro Gly Glu Gly Gly 260 265 270 Lys Pro Gly Glu Gly Glu Gly Lys Pro Gly Gly Lys Pro Glu Gly Glu 275 280 285 Gly Lys Pro Gly Gly Glu Gly Gly Gly Lys Pro Glu Gly Lys Pro Gly 290 295 300 Gly Gly Glu Gly Gly Lys Pro Glu Gly Gly Lys Pro Gly Glu Gly Gly 305 310 315 320 Lys Pro Glu Gly Gly Lys Pro Gly Glu Gly Gly Glu Gly Lys Pro Gly 325 330 335 Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Glu Gly Gly Gly Lys Pro 340 345 350 Glu Gly Glu Gly Lys Pro Gly Gly Gly Gly Lys Pro Gly Glu Gly Gly 355 360 365 Lys Pro Glu Gly Gly Lys Pro Glu Gly Gly Gly Glu Gly Lys Pro Gly 370 375 380 Gly Gly Lys Pro Glu Gly Glu Gly Lys Pro Gly Gly Gly Glu Gly Lys 385 390 395 400 Pro Gly Gly Lys Pro Glu Gly Gly Gly Gly Lys Pro Gly Glu Gly Gly 405 410 415 Lys Pro Glu Gly Gly Lys Pro Gly Gly Glu Gly Gly Gly Lys Pro Glu 420 425 430 Gly Glu Gly Lys Pro Gly Gly Lys Pro Gly Glu Gly Gly Gly Gly Lys 435 440 445 Pro Gly Gly Lys Pro Glu Gly Glu Gly Lys Pro Gly Glu Gly Gly Glu 450 455 460 Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Gly Glu Gly Lys Pro Gly 465 470 475 480 Gly Lys Pro Glu Gly Gly Gly Glu Gly Lys Pro Gly Gly Gly Lys Pro 485 490 495 Gly Glu Gly Gly Lys Pro Glu Gly Gly Gly Lys Pro Gly Glu Gly Gly 500 505 510 Lys Pro Gly Glu Gly Gly Lys Pro Glu Gly Glu Gly Lys Pro Gly Gly 515 520 525 Gly Glu Gly Lys Pro Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Glu 530 535 540 Gly Gly Gly Glu Gly Lys Pro Gly Gly Lys Pro Gly Gly Glu Gly Gly 545 550 555 560 Gly Lys Pro Glu Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Glu Gly 565 570 575 <![CDATA[<210> 319]]> <![CDATA[<211> 558]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 319]]> Gly Glu Gly Lys Pro Gly Gly Lys Pro Gly Ser Gly Gly Gly Lys Pro 1 5 10 15 Gly Glu Gly Gly Lys Pro Gly Ser Gly Glu Gly Lys Pro Gly Gly Lys 20 25 30 Pro Gly Ser Gly Gly Ser Gly Lys Pro Gly Gly Lys Pro Gly Glu Gly 35 40 45 Gly Lys Pro Glu Gly Gly Ser Gly Gly Lys Pro Gly Gly Gly Gly Lys 50 55 60 Pro Gly Gly Lys Pro Gly Gly Glu Gly Ser Gly Lys Pro Gly Gly Lys 65 70 75 80 Pro Glu Gly Gly Gly Lys Pro Glu Gly Gly Ser Gly Gly Lys Pro Gly 85 90 95 Gly Lys Pro Glu Gly Gly Ser Gly Gly Lys Pro Gly Gly Lys Pro Gly 100 105 110 Ser Gly Glu Gly Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Glu Gly 115 120 125 Lys Pro Gly Ser Gly Lys Pro Gly Gly Glu Gly Ser Gly Lys Pro Gly 130 135 140 Gly Lys Pro Glu Gly Gly Ser Gly Gly Lys Pro Gly Gly Lys Pro Glu 145 150 155 160 Gly Gly Ser Gly Gly Lys Pro Gly Gly Ser Gly Lys Pro Gly Gly Lys 165 170 175 Pro Gly Glu Gly Gly Lys Pro Glu Gly Gly Ser Gly Gly Lys Pro Gly 180 185 190 Gly Ser Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Gly Ser Gly Lys 195 200 205 Pro Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Gly Ser Gly Glu Gly 210 215 220 Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Glu Gly Lys Pro Gly Ser 225 230 235 240 Gly Lys Pro Gly Gly Glu Gly Ser Gly Lys Pro Gly Gly Lys Pro Gly 245 250 255 Ser Gly Gly Glu Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Ser Gly 260 265 270 Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Glu Gly Lys Pro Gly Ser 275 280 285 Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Gly Ser Gly Gly Gly Lys 290 295 300 Pro Gly Gly Lys Pro Gly Gly Glu Gly Glu Gly Lys Pro Gly Gly Lys 305 310 315 320 Pro Gly Glu Gly Gly Lys Pro Gly Gly Glu Gly Ser Gly Lys Pro Gly 325 330 335 Gly Gly Gly Lys Pro Gly Gly Lys Pro Gly Gly Glu Gly Gly Lys Pro 340 345 350 Glu Gly Ser Gly Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Gly Lys 355 360 365 Pro Glu Gly Gly Gly Gly Lys Pro Glu Gly Ser Gly Lys Pro Gly Gly 370 375 380 Gly Gly Lys Pro Glu Gly Ser Gly Lys Pro Gly Gly Gly Lys Pro Glu 385 390 395 400 Gly Gly Ser Gly Gly Lys Pro Gly Gly Ser Gly Lys Pro Gly Gly Lys 405 410 415 Pro Gly Glu Gly Gly Gly Lys Pro Glu Gly Ser Gly Lys Pro Gly Gly 420 425 430 Gly Ser Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Gly Lys Pro Glu 435 440 445 Gly Gly Ser Gly Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Ser Gly 450 455 460 Gly Lys Pro Gly Gly Lys Pro Gly Gly Glu Gly Ser Gly Lys Pro Gly 465 470 475 480 Gly Lys Pro Gly Ser Gly Glu Gly Gly Lys Pro Gly Gly Lys Pro Gly 485 490 495 Glu Gly Ser Gly Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly Ser Gly 500 505 510 Gly Lys Pro Gly Gly Ser Gly Lys Pro Gly Gly Lys Pro Glu Gly Gly 515 520 525 Gly Ser Gly Lys Pro Gly Gly Lys Pro Gly Glu Gly Gly Lys Pro Gly 530 535 540 Gly Glu Gly Ser Gly Lys Pro Gly Gly Ser Gly Lys Pro Gly 545 550 555 <![CDATA[<210> 320]]> <![CDATA[<211> 577]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 320]]> Gly Gly Ser Gly Lys Pro Gly Lys Pro Gly Gly Ser Gly Ser Gly Lys 1 5 10 15 Pro Gly Ser Gly Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Ser Gly 20 25 30 Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly 35 40 45 Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly Gly Gly Lys Pro 50 55 60 Gly Ser Gly Ser Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Ser Gly 65 70 75 80 Gly Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Lys Pro Gly Ser Gly 85 90 95 Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly Gly Ser Gly Gly 100 105 110 Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Gly Lys Pro Gly Lys 115 120 125 Pro Gly Ser Gly Gly Gly Ser Gly Lys Pro Gly Lys Pro Gly Ser Gly 130 135 140 Gly Ser Gly Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Gly 145 150 155 160 Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Lys Pro Gly Ser Gly 165 170 175 Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 180 185 190 Gly Gly Ser Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Lys 195 200 205 Pro Gly Ser Gly Lys Pro Gly Ser Gly Ser Gly Lys Pro Gly Ser Gly 210 215 220 Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser 225 230 235 240 Gly Gly Ser Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Gly Lys Pro 245 250 255 Gly Ser Gly Ser Gly Lys Pro Gly Gly Gly Lys Pro Gly Ser Gly Ser 260 265 270 Gly Lys Pro Gly Gly Gly Lys Pro Gly Gly Ser Gly Gly Lys Pro Gly 275 280 285 Gly Ser Gly Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Gly Ser Gly 290 295 300 Lys Pro Gly Lys Pro Gly Ser Gly Gly Gly Ser Gly Lys Pro Gly Lys 305 310 315 320 Pro Gly Gly Ser Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly 325 330 335 Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Ser Gly Gly Ser Gly 340 345 350 Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Gly Lys Pro Gly Lys 355 360 365 Pro Gly Ser Gly Gly Gly Lys Pro Gly Ser Gly Ser Gly Lys Pro Gly 370 375 380 Gly Gly Lys Pro Gly Ser Gly Ser Gly Lys Pro Gly Gly Gly Lys Pro 385 390 395 400 Gly Ser Gly Ser Gly Lys Pro Gly Gly Gly Lys Pro Gly Ser Gly Ser 405 410 415 Gly Lys Pro Gly Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly 420 425 430 Gly Ser Gly Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Lys 435 440 445 Pro Gly Ser Gly Lys Pro Gly Ser Gly Gly Ser Gly Lys Pro Gly Lys 450 455 460 Pro Gly Gly Ser Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly 465 470 475 480 Gly Ser Gly Lys Pro Gly Ser Gly Lys Pro Gly Gly Gly Ser Gly Lys 485 490 495 Pro Gly Ser Gly Lys Pro Gly Gly Gly Ser Gly Lys Pro Gly Ser Gly 500 505 510 Lys Pro Gly Gly Gly Gly Lys Pro Gly Ser Gly Ser Gly Lys Pro Gly 515 520 525 Gly Ser Gly Gly Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Gly 530 535 540 Lys Pro Gly Lys Pro Gly Ser Gly Gly Ser Gly Lys Pro Gly Ser Gly 545 550 555 560 Lys Pro Gly Gly Gly Ser Gly Gly Lys Pro Gly Lys Pro Gly Ser Gly 565 570 575 Gly <![CDATA[<210> 321]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 321]]> Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser 1 5 10 15 Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Gly Ser 20 25 30 Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly 35 40 45 Gly Glu Gly Ser Gly Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly 50 55 60 Glu Gly Gly Gly Glu Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Gly 65 70 75 80 Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly Ser Glu 85 90 95 Gly Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser 100 105 110 Glu Gly Gly Ser Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu 115 120 125 Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu 130 135 140 Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser 145 150 155 160 Gly Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly Ser 165 170 175 Glu Gly Ser Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly 180 185 190 Gly Ser Glu Gly Ser Glu Gly Glu Gly Gly Gly Glu Gly Ser Glu Gly 195 200 205 Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Ser Glu Gly Ser 210 215 220 Glu Gly Glu Gly Gly Ser Glu Gly Ser Glu Gly Glu Gly Gly Glu Gly 225 230 235 240 Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser 245 250 255 Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu 260 265 270 Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Gly Ser Glu Gly Ser Glu 275 280 285 Gly Glu Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser 290 295 300 Gly Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Gly Ser 305 310 315 320 Glu Gly Ser Glu Gly Glu Gly Gly Ser Glu Gly Ser Glu Gly Glu Gly 325 330 335 Gly Ser Glu Gly Ser Glu Gly Glu Gly Gly Glu Gly Ser Gly Glu Gly 340 345 350 Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Gly Glu Gly Ser 355 360 365 Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly 370 375 380 Ser Gly Glu Gly Glu Gly Gly Ser Glu Gly Ser Glu Gly Glu Gly Ser 385 390 395 400 Glu Gly Ser Gly Glu Gly Glu Gly Gly Glu Gly Ser Gly Glu Gly Glu 405 410 415 Gly Ser Gly Glu Gly Ser Glu Gly Glu Gly Gly Gly Glu Gly Ser Glu 420 425 430 Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Glu Gly Ser 435 440 445 Gly Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly Ser 450 455 460 Glu Gly Ser Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly 465 470 475 480 Ser Glu Gly Gly Ser Glu Gly Glu Gly Ser Glu Gly Ser Gly Glu Gly 485 490 495 Glu Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Gly Glu Gly Ser 500 505 510 Glu Gly Glu Gly Gly Ser Glu Gly Gly Glu Gly Glu Gly Ser Glu Gly 515 520 525 Gly Ser Glu Gly Glu Gly Ser Glu Gly Gly Ser Glu Gly Glu Gly Gly 530 535 540 Glu Gly Ser Gly Glu Gly Glu Gly Gly Gly Glu Gly Ser Glu Gly Glu 545 550 555 560 Gly Ser Glu Gly Ser Gly Glu Gly Glu Gly Ser Gly Glu Gly Ser Glu 565 570 575 <![CDATA[<210> 322]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 322]]> Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 1 5 10 15 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 20 25 30 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 35 40 45 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu 50 55 60 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 65 70 75 80 Glu Gly Gly Pro Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 85 90 95 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 100 105 110 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser 115 120 125 Glu Gly Gly Pro Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 130 135 140 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 145 150 155 160 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 165 170 175 Gly Ser Glu Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 180 185 190 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly 195 200 205 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 210 215 220 Ser Gly Ser Ser Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 225 230 235 240 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Gly Gly 245 250 255 Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu 260 265 270 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 275 280 285 Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro Gly Glu Ser Pro 290 295 300 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 305 310 315 320 Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser 325 330 335 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro 340 345 350 Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser 355 360 365 Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 370 375 380 Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu 385 390 395 400 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 405 410 415 Ser Gly Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 420 425 430 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Glu Ser Pro 435 440 445 Gly Gly Ser Ser Gly Ser Glu Ser Gly Glu Ser Pro Gly Gly Ser Ser 450 455 460 Gly Ser Glu Ser Gly Ser Ser Glu Ser Gly Ser Ser Glu Gly Gly Pro 465 470 475 480 Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser Gly Ser Ser Glu 485 490 495 Ser Gly Ser Ser Glu Gly Gly Pro Gly Ser Gly Gly Glu Pro Ser Glu 500 505 510 Ser Gly Ser Ser Gly Ser Gly Gly Glu Pro Ser Glu Ser Gly Ser Ser 515 520 525 Gly Glu Ser Pro Gly Gly Ser Ser Gly Ser Glu Ser Gly Ser Glu Gly 530 535 540 Ser Ser Gly Pro Gly Glu Ser Ser Gly Ser Ser Glu Ser Gly Ser Ser 545 550 555 560 Glu Gly Gly Pro Gly Ser Glu Gly Ser Ser Gly Pro Gly Glu Ser Ser 565 570 575 <![CDATA[<210> 323]]> <![CDATA[<211> 577]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 323]]> Ala Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 35 40 45 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 65 70 75 80 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 85 90 95 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 165 170 175 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 290 295 300 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 305 310 315 320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 355 360 365 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 435 440 445 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 485 490 495 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 515 520 525 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 530 535 540 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro <![CDATA[<210> 324]]> <![CDATA[<211> 540]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 324]]> Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 1 5 10 15 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 85 90 95 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 130 135 140 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 165 170 175 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 180 185 190 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 225 230 235 240 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 275 280 285 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr 290 295 300 Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly 305 310 315 320 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 325 330 335 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 340 345 350 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 370 375 380 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 420 425 430 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser 435 440 445 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 450 455 460 Ser Ala Ser Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 465 470 475 480 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 485 490 495 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu 500 505 510 Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 515 520 525 Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 530 535 540 <![CDATA[<210> 325]]> <![CDATA[<211> 504]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 325]]> Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro 1 5 10 15 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 20 25 30 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 35 40 45 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Asn Pro 50 55 60 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser 65 70 75 80 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 85 90 95 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 100 105 110 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 115 120 125 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 130 135 140 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 145 150 155 160 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 165 170 175 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 180 185 190 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Asn Pro 195 200 205 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr 210 215 220 Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 225 230 235 240 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 245 250 255 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 260 265 270 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 275 280 285 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 290 295 300 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 305 310 315 320 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 325 330 335 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly 340 345 350 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 355 360 365 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 370 375 380 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr 385 390 395 400 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 405 410 415 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 420 425 430 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 435 440 445 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 450 455 460 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 465 470 475 480 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 485 490 495 Gly Thr Ser Ser Thr Gly Ser Pro 500 <![CDATA[<210> 326]]> <![CDATA[<211> 816]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 326]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 <![CDATA[<210> 327]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (430)..(432)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (443)..(446)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 327]]> Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro 1 5 10 15 Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 20 25 30 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 50 55 60 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 85 90 95 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 100 105 110 Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 115 120 125 Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro 130 135 140 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro 145 150 155 160 Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser 165 170 175 Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 180 185 190 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr 195 200 205 Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 210 215 220 Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 225 230 235 240 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 245 250 255 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser Gly 260 265 270 Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro 275 280 285 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 290 295 300 Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser 305 310 315 320 Ser Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 325 330 335 Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser 340 345 350 Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu 355 360 365 Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 370 375 380 Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser 385 390 395 400 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 405 410 415 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Pro Xaa Xaa Xaa 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Xaa Xaa Xaa Xaa Ser Glu 435 440 445 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 450 455 460 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 465 470 475 480 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 500 505 510 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 515 520 525 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 530 535 540 Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 565 570 575 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro 625 630 635 640 Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser 645 650 655 Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Ser 675 680 685 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 690 695 700 Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 705 710 715 720 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Ser 725 730 735 Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly 755 760 765 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 770 775 780 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 785 790 795 800 Thr Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 805 810 815 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Pro Ser 820 825 830 Gly Glu Ser Ser Thr Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 835 840 845 Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 865 870 875 <![CDATA[<210> 328]]> <![CDATA[<211> 868]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 328]]> Gly Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 1 5 10 15 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 20 25 30 Ser Ala Ser Thr Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala 35 40 45 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 50 55 60 Gly Ser Asn Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 65 70 75 80 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 85 90 95 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 100 105 110 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 115 120 125 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 130 135 140 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 145 150 155 160 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro 165 170 175 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 180 185 190 Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 195 200 205 Gly Ser Asn Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Pro 210 215 220 Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser Gly Ala 225 230 235 240 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 245 250 255 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 260 265 270 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 275 280 285 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 290 295 300 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 305 310 315 320 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 325 330 335 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 340 345 350 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ala Ser Pro 355 360 365 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 370 375 380 Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 385 390 395 400 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 405 410 415 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 420 425 430 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 435 440 445 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 450 455 460 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 465 470 475 480 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 485 490 495 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 500 505 510 Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 515 520 525 Ser Ser Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro 530 535 540 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro 545 550 555 560 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 565 570 575 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 580 585 590 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly 595 600 605 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 610 615 620 Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 625 630 635 640 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 645 650 655 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 660 665 670 Gly Thr Gly Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 675 680 685 Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly 690 695 700 Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala 705 710 715 720 Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro 725 730 735 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 740 745 750 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 755 760 765 Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 770 775 780 Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro 785 790 795 800 Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr 805 810 815 Gly Thr Gly Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro 820 825 830 Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr 835 840 845 Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser 850 855 860 Thr Gly Ser Pro 865 <![CDATA[<210> 329]]> <![CDATA[<211> 875]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 329]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu Ser 435 440 445 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 450 455 460 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 500 505 510 Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 515 520 525 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 530 535 540 Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 545 550 555 560 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 565 570 575 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser Ser 580 585 590 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 595 600 605 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 625 630 635 640 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 645 650 655 Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 675 680 685 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr Pro 725 730 735 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 740 745 750 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 755 760 765 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 770 775 780 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 785 790 795 800 Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 805 810 815 Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly 820 825 830 Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 835 840 845 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 850 855 860 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 865 870 875 <![CDATA[<210> 330]]> <![CDATA[<211> 1318]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 330]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Pro Glu Pro Thr Gly Pro Ala Pro Ser Gly Gly Ser Glu Pro Ala 435 440 445 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 450 455 460 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 485 490 495 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 500 505 510 Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 515 520 525 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly 530 535 540 Ser Pro Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser 545 550 555 560 Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly 565 570 575 Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Thr Ser Glu 580 585 590 Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly 595 600 605 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 625 630 635 640 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 645 650 655 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 660 665 670 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 675 680 685 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Pro Ser 725 730 735 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 740 745 750 Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 755 760 765 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 770 775 780 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 785 790 795 800 Ser Ala Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly 805 810 815 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro 820 825 830 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr 835 840 845 Gly Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 850 855 860 Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ala Ser Ala Ser 865 870 875 880 Gly Ala Pro Ser Thr Gly Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr 885 890 895 Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr 900 905 910 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala 915 920 925 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 930 935 940 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 945 950 955 960 Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ser Ser Thr Pro Ser 965 970 975 Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly 980 985 990 Ser Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr 995 1000 1005 Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Pro Ser 1010 1015 1020 Gly Glu Ser Ser Thr Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1025 1030 1035 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1040 1045 1050 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 1055 1060 1065 Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu 1070 1075 1080 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly 1085 1090 1095 Ser Ala Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1100 1105 1110 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1115 1120 1125 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 1130 1135 1140 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 1145 1150 1155 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 1160 1165 1170 Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala 1175 1180 1185 Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Ser Thr Pro 1190 1195 1200 Ser Gly Ala Thr Gly Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser 1205 1210 1215 Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala 1220 1225 1230 Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser 1235 1240 1245 Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ala Ser Pro Gly 1250 1255 1260 Thr Ser Ser Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly Thr Ala 1265 1270 1275 Ser Ser Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1280 1285 1290 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1295 1300 1305 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1310 1315 <![CDATA[<210> 331]]> <![CDATA[<211> 1018]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 331]]> Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 1 5 10 15 Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 20 25 30 Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 35 40 45 Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 50 55 60 Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 65 70 75 80 Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 85 90 95 Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 100 105 110 Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 115 120 125 Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 130 135 140 Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Ser Pro Ala Gly Ser 145 150 155 160 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 165 170 175 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 180 185 190 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 195 200 205 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 210 215 220 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 225 230 235 240 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr 245 250 255 Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 260 265 270 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 275 280 285 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 290 295 300 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 305 310 315 320 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 325 330 335 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 340 345 350 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 355 360 365 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 370 375 380 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro 385 390 395 400 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 405 410 415 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 420 425 430 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 435 440 445 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 450 455 460 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 465 470 475 480 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 485 490 495 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 500 505 510 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 515 520 525 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 530 535 540 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 545 550 555 560 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 565 570 575 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 580 585 590 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 595 600 605 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 610 615 620 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 625 630 635 640 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 645 650 655 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 660 665 670 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 675 680 685 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 690 695 700 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 705 710 715 720 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 725 730 735 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 740 745 750 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 755 760 765 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 770 775 780 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 785 790 795 800 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 805 810 815 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 820 825 830 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 835 840 845 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 850 855 860 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 865 870 875 880 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 885 890 895 Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 900 905 910 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 915 920 925 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 930 935 940 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 945 950 955 960 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 965 970 975 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 980 985 990 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 995 1000 1005 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1010 1015 <![CDATA[<210> 332]]> <![CDATA[<211> 1029]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 332]]> Met Arg Pro Ser Gly Arg Lys Ser Ser Lys Met Gln Ala Phe Arg Ile 1 5 10 15 Trp Asp Val Asn Gln Lys Thr Phe Tyr Leu Arg Asn Asn Gln Leu Val 20 25 30 Ala Gly Tyr Leu Gln Gly Pro Asn Val Asn Leu Glu Glu Lys Ile Asp 35 40 45 Val Val Pro Ile Glu Pro His Ala Leu Phe Leu Gly Ile His Gly Gly 50 55 60 Lys Met Cys Leu Ser Cys Val Lys Ser Gly Asp Glu Thr Arg Leu Gln 65 70 75 80 Leu Glu Ala Val Asn Ile Thr Asp Leu Ser Glu Asn Arg Lys Gln Asp 85 90 95 Lys Arg Phe Ala Phe Ile Arg Ser Asp Ser Gly Pro Thr Thr Ser Phe 100 105 110 Glu Ser Ala Ala Cys Pro Gly Trp Phe Leu Cys Thr Ala Met Glu Ala 115 120 125 Asp Gln Pro Val Ser Leu Thr Asn Met Pro Asp Glu Gly Val Met Val 130 135 140 Thr Lys Phe Tyr Phe Gln Glu Asp Glu Gly Gly Thr Ser Thr Glu Pro 145 150 155 160 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 165 170 175 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 180 185 190 Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu 195 200 205 Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr 210 215 220 Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala Pro Gly Thr 225 230 235 240 Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Thr Ser Thr Pro Glu 245 250 255 Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 260 265 270 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 275 280 285 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 290 295 300 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 305 310 315 320 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 325 330 335 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 340 345 350 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 355 360 365 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 370 375 380 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 385 390 395 400 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 405 410 415 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 420 425 430 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 435 440 445 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 450 455 460 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 465 470 475 480 Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Pro Gly Ser Gly 485 490 495 Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly 500 505 510 Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 515 520 525 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr 530 535 540 Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 545 550 555 560 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 565 570 575 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ala Ser Ala Ser Gly 580 585 590 Ala Pro Ser Thr Gly Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 595 600 605 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 610 615 620 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala 625 630 635 640 Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala 645 650 655 Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Thr Pro 660 665 670 Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr Pro Ser Gly 675 680 685 Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly 690 695 700 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 705 710 715 720 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 725 730 735 Gly Ser Glu Thr Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly 740 745 750 Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser 755 760 765 Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly Ser Glu Pro Ala Thr Ser 770 775 780 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 785 790 795 800 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Thr 805 810 815 Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Thr Ser Thr Pro Glu Ser 820 825 830 Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu Ser Pro Ser Gly Thr Ala 835 840 845 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 850 855 860 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 865 870 875 880 Glu Gly Ser Ala Pro Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser 885 890 895 Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser 900 905 910 Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly Ser Glu Pro Ala Thr Ser 915 920 925 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 930 935 940 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Ser 945 950 955 960 Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser 965 970 975 Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser 980 985 990 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 995 1000 1005 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1010 1015 1020 Ser Glu Gly Ser Ala Pro 1025 <![CDATA[<210> 333]]> <![CDATA[<211> 1042]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 333]]> Met His Ser Ser Ala Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val 1 5 10 15 Arg Ala Ser Pro Gly Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His 20 25 30 Phe Pro Gly Asn Leu Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe 35 40 45 Ser Arg Val Lys Thr Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu 50 55 60 Leu Leu Lys Glu Ser Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys 65 70 75 80 Gln Ala Leu Ser Glu Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro 85 90 95 Gln Ala Glu Asn Gln Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu 100 105 110 Gly Glu Asn Leu Lys Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg 115 120 125 Phe Leu Pro Cys Glu Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn 130 135 140 Ala Phe Asn Lys Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu 145 150 155 160 Phe Asp Ile Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile 165 170 175 Arg Asn Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 180 185 190 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 195 200 205 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 210 215 220 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 225 230 235 240 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 245 250 255 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 260 265 270 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 275 280 285 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 290 295 300 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 305 310 315 320 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 325 330 335 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 340 345 350 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 355 360 365 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 370 375 380 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 385 390 395 400 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 405 410 415 Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 420 425 430 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 435 440 445 Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 450 455 460 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 465 470 475 480 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 485 490 495 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 500 505 510 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 515 520 525 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 530 535 540 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 545 550 555 560 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 565 570 575 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 580 585 590 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 595 600 605 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 610 615 620 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 625 630 635 640 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 645 650 655 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 660 665 670 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 675 680 685 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 690 695 700 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 705 710 715 720 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 725 730 735 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 740 745 750 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 755 760 765 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 770 775 780 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 785 790 795 800 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 805 810 815 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 820 825 830 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 835 840 845 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 850 855 860 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 865 870 875 880 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 885 890 895 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 900 905 910 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 915 920 925 Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 930 935 940 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 945 950 955 960 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 965 970 975 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 980 985 990 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 995 1000 1005 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1010 1015 1020 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 1025 1030 1035 Gly Ser Ala Pro 1040 <![CDATA[<210> 334]]> <![CDATA[<211> 1053]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 334]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 1 5 10 15 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 20 25 30 Ser Thr Glu Glu Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro 35 40 45 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser 50 55 60 Glu Ser Pro Ser Gly Thr Ala Pro Gly Ser Thr Ser Glu Ser Pro Ser 65 70 75 80 Gly Thr Ala Pro Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro 85 90 95 Gly Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Glu Pro 100 105 110 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 210 215 220 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 260 265 270 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 290 295 300 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 305 310 315 320 Ser Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro 325 330 335 Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly Ser Ser Thr 340 345 350 Pro Ser Gly Ala Thr Gly Ser Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 385 390 395 400 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Ala Ser Ala Ser Gly Ala Pro Ser Thr Gly Gly Thr Ser Glu Ser 435 440 445 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 450 455 460 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 465 470 475 480 Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Glu 485 490 495 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser 500 505 510 Thr Ala Pro Gly Thr Pro Gly Ser Gly Thr Ala Ser Ser Ser Pro Gly 515 520 525 Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser 530 535 540 Ala Ser Thr Gly Thr Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 545 550 555 560 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 565 570 575 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Thr Ser Ser 580 585 590 Thr Ala Glu Ser Pro Gly Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser 595 600 605 Pro Gly Pro Gly Thr Ser Pro Ser Gly Glu Ser Ser Thr Ala Pro Gly 610 615 620 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala 625 630 635 640 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 645 650 655 Ser Ala Pro Gly Ser Thr Ser Ser Thr Ala Glu Ser Pro Gly Pro Gly 660 665 670 Thr Ser Thr Pro Glu Ser Gly Ser Ala Ser Pro Gly Ser Thr Ser Glu 675 680 685 Ser Pro Ser Gly Thr Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 690 695 700 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 705 710 715 720 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Ser Thr Pro 725 730 735 Ser Gly Ala Thr Gly Ser Pro Gly Ser Ser Pro Ser Ala Ser Thr Gly 740 745 750 Thr Gly Pro Gly Ala Ser Pro Gly Thr Ser Ser Thr Gly Ser Pro Gly 755 760 765 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 770 775 780 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 785 790 795 800 Thr Glu Glu Gly Ser Ser Thr Pro Ser Gly Ala Thr Gly Ser Pro Gly 805 810 815 Ser Ser Pro Ser Ala Ser Thr Gly Thr Gly Pro Gly Ala Ser Pro Gly 820 825 830 Thr Ser Ser Thr Gly Ser Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 835 840 845 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 850 855 860 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Met His Ser Ser Ala 865 870 875 880 Leu Leu Cys Cys Leu Val Leu Leu Thr Gly Val Arg Ala Ser Pro Gly 885 890 895 Gln Gly Thr Gln Ser Glu Asn Ser Cys Thr His Phe Pro Gly Asn Leu 900 905 910 Pro Asn Met Leu Arg Asp Leu Arg Asp Ala Phe Ser Arg Val Lys Thr 915 920 925 Phe Phe Gln Met Lys Asp Gln Leu Asp Asn Leu Leu Leu Lys Glu Ser 930 935 940 Leu Leu Glu Asp Phe Lys Gly Tyr Leu Gly Cys Gln Ala Leu Ser Glu 945 950 955 960 Met Ile Gln Phe Tyr Leu Glu Glu Val Met Pro Gln Ala Glu Asn Gln 965 970 975 Asp Pro Asp Ile Lys Ala His Val Asn Ser Leu Gly Glu Asn Leu Lys 980 985 990 Thr Leu Arg Leu Arg Leu Arg Arg Cys His Arg Phe Leu Pro Cys Glu 995 1000 1005 Asn Lys Ser Lys Ala Val Glu Gln Val Lys Asn Ala Phe Asn Lys 1010 1015 1020 Leu Gln Glu Lys Gly Ile Tyr Lys Ala Met Ser Glu Phe Asp Ile 1025 1030 1035 Phe Ile Asn Tyr Ile Glu Ala Tyr Met Thr Met Lys Ile Arg Asn 1040 1045 1050 <![CDATA[<210> 335]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 335]]> Gly Ser Ala Pro Gly Ser Ala Gly Gly Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 336]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 336]]> Gly Ser Ala Pro Gly Thr Gly Gly Gly Tyr Ala Pro Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 337]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 337]]> Gly Ser Ala Pro Gly Ala Glu Gly Gly Tyr Ala Ala Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 338]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 338]]> Gly Ser Ala Pro Gly Gly Pro Gly Gly Tyr Ala Leu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 339]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 339]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Phe Leu Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 340]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 340]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Ser Leu Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 341]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 341]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Thr Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 342]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 342]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Asn Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 343]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 343]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala His Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 344]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 344]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Gly Glu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 345]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 345]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Pro Glu Leu Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 346]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 346]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Val Glu Leu Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 347]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 347]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Leu Glu Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 348]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 348]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ser Glu Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 349]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 349]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Thr Glu Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 350]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 350]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Gln Glu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 351]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 351]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Glu Glu Leu Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 352]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 352]]> Gly Ser Ala Pro Gly Pro Gly Ile Gly Pro Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 353]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 353]]> Gly Ser Ala Pro Gly Ser Glu Ile Gly Ala Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 354]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 354]]> Gly Ser Ala Pro Gly Thr Pro Ile Gly Ser Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 355]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 355]]> Gly Ser Ala Pro Gly Ala Ser Ile Gly Thr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 356]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 356]]> Gly Ser Ala Pro Gly Gly Thr Ile Gly Asn Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 357]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 357]]> Gly Ser Ala Pro Gly Glu Ala Ile Gly Gln Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 358]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 358]]> Gly Ser Ala Pro Gly Pro Gly Gly Pro Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 359]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 359]]> Gly Ser Ala Pro Gly Ser Glu Gly Ala Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 360]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 360]]> Gly Ser Ala Pro Gly Thr Pro Gly Val Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 361]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 361]]> Gly Ser Ala Pro Gly Ala Ser Gly Leu Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 362]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 362]]> Gly Ser Ala Pro Gly Gly Thr Gly Ile Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 363]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 363]]> Gly Ser Ala Pro Gly Glu Ala Gly Phe Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 364]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 364]]> Gly Ser Ala Pro Gly Pro Gly Gly Tyr Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 365]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 365]]> Gly Ser Ala Pro Gly Ser Glu Gly Ser Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 366]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 366]]> Gly Ser Ala Pro Gly Thr Pro Gly Asn Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 367]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 367]]> Gly Ser Ala Pro Gly Ala Ser Gly Glu Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 368]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 368]]> Gly Ser Ala Pro Gly Gly Thr Gly His Tyr Ala Glu Leu Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 369]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 369]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Ala Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 370]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 370]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Val Arg Met Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 371]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 371]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Ile Arg Met Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 372]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 372]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Phe Arg Met Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 373]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 373]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Tyr Arg Met Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 374]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 374]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Ser Arg Met Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 375]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 375]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Thr Arg Met Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 376]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 376]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Ala Met Gly 1 5 10 15 Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 377]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 377]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Val Met Gly 1 5 10 15 Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 378]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 378]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Leu Met Gly 1 5 10 15 Gly Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 379]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 379]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Ile Met Gly 1 5 10 15 Gly Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 380]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 380]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Trp Met Gly 1 5 10 15 Gly Pro Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 381]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 381]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Ser Met Gly 1 5 10 15 Gly Ser Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 382]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 382]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Thr Met Gly 1 5 10 15 Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 383]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 383]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Gln Met Gly 1 5 10 15 Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 384]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 384]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Asn Met Gly 1 5 10 15 Gly Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 385]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 385]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Glu Met Gly 1 5 10 15 Gly Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 386]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 386]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Pro Gly 1 5 10 15 Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 387]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 387]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Ala Gly 1 5 10 15 Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 388]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 388]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Leu Gly 1 5 10 15 Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 389]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 389]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg Ile Gly 1 5 10 15 Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 390]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 390]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Ser Gly 1 5 10 15 Gly Gly Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 391]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 391]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Asn Gly 1 5 10 15 Gly Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 392]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 392]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Gln Gly 1 5 10 15 Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 393]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 393]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Asp Gly 1 5 10 15 Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 394]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 394]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Glu Gly 1 5 10 15 Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 395]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 395]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg His Gly 1 5 10 15 Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 396]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 396]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Met Pro 1 5 10 15 Gly Gly Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 397]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 397]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Met Ala 1 5 10 15 Gly Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 398]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 398]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Met Val 1 5 10 15 Gly Pro Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 399]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 399]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Tyr Ala Glu Leu Arg Met Leu 1 5 10 15 Gly Ser Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 400]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 400]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Tyr Ala Glu Leu Arg Met Ile 1 5 10 15 Gly Thr Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 401]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 401]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Tyr Ala Glu Leu Arg Met Tyr 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 402]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 402]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Tyr Ala Glu Leu Arg Met Ser 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 403]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 403]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Tyr Ala Glu Leu Arg Met Asn 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 404]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 404]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Tyr Ala Glu Leu Arg Met Gln 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 405]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 405]]> Gly Ser Ala Pro Gly Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 1 5 10 15 Gly Ala Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 406]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 406]]> Gly Ser Ala Pro Gly Ala Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro 1 5 10 15 Ser Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 407]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 407]]> Gly Ser Ala Pro Gly Thr Gly Ala Pro Pro Gly Gly Leu Thr Gly Pro 1 5 10 15 Gly Thr Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 408]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 408]]> Gly Ser Ala Pro Gly Ala Asn His Glu Pro Ser Gly Leu Thr Glu Gly 1 5 10 15 Ser Pro Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 409]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 409]]> Gly Ser Ala Pro Gly Ala Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly 1 5 10 15 Thr Glu Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 410]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 410]]> Gly Ser Ala Pro Gly Ala Ser Gly Pro Pro Pro Gly Leu Thr Gly Pro 1 5 10 15 Pro Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 411]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 411]]> Gly Ser Ala Pro Gly Ala Ser Gly Thr Pro Ala Pro Leu Gly Gly Glu 1 5 10 15 Pro Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 412]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 412]]> Gly Ser Ala Pro Gly Pro Ala Gly Pro Pro Glu Gly Leu Glu Thr Glu 1 5 10 15 Ala Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 413]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 413]]> Gly Ser Ala Pro Gly Pro Thr Ser Gly Gln Gly Gly Leu Thr Gly Pro 1 5 10 15 Glu Ser Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 414]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 414]]> Gly Ser Ala Pro Gly Ser Ala Gly Gly Ala Ala Asn Leu Val Arg Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 415]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 415]]> Gly Ser Ala Pro Gly Thr Gly Gly Gly Ala Ala Pro Leu Val Arg Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 416]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 416]]> Gly Ser Ala Pro Gly Ala Glu Gly Gly Ala Ala Ala Leu Val Arg Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 417]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 417]]> Gly Ser Ala Pro Gly Gly Pro Gly Gly Ala Ala Leu Leu Val Arg Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 418]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 418]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Ala Phe Leu Val Arg Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 419]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 419]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Ala Ala Ser Leu Val Arg Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 420]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 420]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Ala Ala Thr Leu Val Arg Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 421]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 421]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Ala Ala Gly Leu Val Arg Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 422]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 422]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Ala Ala Asp Leu Val Arg Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 423]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 423]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Ala Gly Asn Leu Val Arg Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 424]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 424]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Pro Asn Leu Val Arg Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 425]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 425]]> Gly Ser Ala Pro Gly Pro Gly Gly Gly Ala Val Asn Leu Val Arg Gly 1 5 10 15 Gly Thr Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 426]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 426]]> Gly Ser Ala Pro Gly Ser Glu Gly Gly Ala Leu Asn Leu Val Arg Gly 1 5 10 15 Gly Ala Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 427]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 427]]> Gly Ser Ala Pro Gly Thr Pro Gly Gly Ala Ser Asn Leu Val Arg Gly 1 5 10 15 Gly Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 428]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 428]]> Gly Ser Ala Pro Gly Ala Ser Gly Gly Ala Thr Asn Leu Val Arg Gly 1 5 10 15 Gly Glu Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 429]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 429]]> Gly Ser Ala Pro Gly Gly Thr Gly Gly Ala Gln Asn Leu Val Arg Gly 1 5 10 15 Gly Pro Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 430]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 430]]> Gly Ser Ala Pro Gly Glu Ala Gly Gly Ala Glu Asn Leu Val Arg Gly 1 5 10 15 Gly Ser Ile Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 <![CDATA[<210> 431]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 431]]> Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly 1 5 10 15 Leu Val Ala Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 432]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 432]]> Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Ser Gly 1 5 10 15 Leu Ala Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 433]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 433]]> Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Gln Gly 1 5 10 15 Leu Ala Gly Gln Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 434]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 434]]> Gly Ser Ala Pro Ala Ser Gly Arg Ser Thr Asn Ala Gly Pro Pro Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 435]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 435]]> Gly Ser Ala Pro Ala Ser Ser Arg Gly Thr Asn Ala Gly Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 436]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 436]]> Gly Ser Ala Pro Ala Ser Ser Arg Thr Thr Asn Thr Gly Pro Ser Thr 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 437]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 437]]> Gly Ser Ala Pro Ala Ala Gly Arg Ser Asp Asn Gly Thr Pro Leu Glu 1 5 10 15 Leu Val Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 438]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 438]]> Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Glu Pro Leu Gly 1 5 10 15 Leu Val Ala Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 439]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 439]]> Gly Ser Ala Pro Ala Ser Gly Arg Gly Thr Asn Ala Gly Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 440]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 440]]> Gly Ser Ala Pro Leu Phe Gly Arg Asn Asp Asn His Glu Pro Leu Glu 1 5 10 15 Leu Gly Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 441]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 441]]> Gly Ser Ala Pro Thr Ala Gly Arg Ser Asp Asn Leu Glu Pro Leu Gly 1 5 10 15 Leu Val Phe Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 442]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 442]]> Gly Ser Ala Pro Leu Asp Gly Arg Ser Asp Asn Phe His Pro Pro Glu 1 5 10 15 Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 443]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 443]]> Gly Ser Ala Pro Leu Glu Gly Arg Ser Asp Asn Glu Glu Pro Glu Asn 1 5 10 15 Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 444]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 444]]> Gly Ser Ala Pro Leu Lys Gly Arg Ser Asp Asn Asn Ala Pro Leu Ala 1 5 10 15 Leu Val Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 445]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 445]]> Gly Ser Ala Pro Val Tyr Ser Arg Gly Thr Asn Ala Gly Pro His Gly 1 5 10 15 Leu Thr Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 446]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 446]]> Gly Ser Ala Pro Ala Asn Ser Arg Gly Thr Asn Lys Gly Phe Ala Gly 1 5 10 15 Leu Ile Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 447]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 447]]> Gly Ser Ala Pro Ala Ser Ser Arg Leu Thr Asn Glu Ala Pro Ala Gly 1 5 10 15 Leu Thr Ile Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 448]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 448]]> Gly Ser Ala Pro Asp Gln Ser Arg Gly Thr Asn Ala Gly Pro Glu Gly 1 5 10 15 Leu Thr Asp Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 449]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 449]]> Gly Ser Ala Pro Glu Ser Ser Arg Gly Thr Asn Ile Gly Gln Gly Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 450]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 450]]> Gly Ser Ala Pro Ser Ser Ser Arg Gly Thr Asn Gln Asp Pro Ala Gly 1 5 10 15 Leu Thr Ile Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 451]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 451]]> Gly Ser Ala Pro Ala Ser Ser Arg Gly Gln Asn His Ser Pro Met Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 452]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 452]]> Gly Ser Ala Pro Ala Tyr Ser Arg Gly Pro Asn Ala Gly Pro Ala Gly 1 5 10 15 Leu Glu Gly Arg Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 453]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 453]]> Gly Ser Ala Pro Ala Ser Glu Arg Gly Asn Asn Ala Gly Pro Ala Asn 1 5 10 15 Leu Thr Gly Phe Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 454]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 454]]> Gly Ser Ala Pro Ala Ser His Arg Gly Thr Asn Pro Lys Pro Ala Ile 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 455]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 455]]> Gly Ser Ala Pro Met Ser Ser Arg Arg Thr Asn Ala Asn Pro Ala Gln 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 456]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 456]]> Gly Ser Ala Pro Gly Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu 1 5 10 15 Leu Gly Ala Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 457]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 457]]> Gly Ser Ala Pro Leu Ala Gly Arg Ser Glu Asn Thr Ala Pro Leu Glu 1 5 10 15 Leu Thr Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 458]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 458]]> Gly Ser Ala Pro Leu Glu Gly Arg Pro Asp Asn His Glu Pro Leu Ala 1 5 10 15 Leu Val Ala Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 459]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 459]]> Gly Ser Ala Pro Leu Ser Gly Arg Ser Asp Asn Glu Glu Pro Leu Ala 1 5 10 15 Leu Pro Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 460]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 460]]> Gly Ser Ala Pro Glu Ala Gly Arg Thr Asp Asn His Glu Pro Leu Glu 1 5 10 15 Leu Ser Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 461]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 461]]> Gly Ser Ala Pro Glu Gly Gly Arg Ser Asp Asn His Gly Pro Leu Glu 1 5 10 15 Leu Val Ser Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 462]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 462]]> Gly Ser Ala Pro Leu Ser Gly Arg Ser Asp Asn Glu Ala Pro Leu Glu 1 5 10 15 Leu Glu Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 463]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 463]]> Gly Ser Ala Pro Leu Gly Gly Arg Ala Asp Asn His Glu Pro Pro Glu 1 5 10 15 Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 464]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 464]]> Gly Ser Ala Pro Pro Pro Ser Arg Gly Thr Asn Ala Glu Pro Ala Gly 1 5 10 15 Leu Thr Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 465]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 465]]> Gly Ser Ala Pro Ala Ser Thr Arg Gly Glu Asn Ala Gly Pro Ala Gly 1 5 10 15 Leu Glu Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 466]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 466]]> Gly Ser Ala Pro Glu Ser Ser Arg Gly Thr Asn Gly Ala Pro Glu Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 467]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 467]]> Gly Ser Ala Pro Ala Ser Ser Arg Ala Thr Asn Glu Ser Pro Ala Gly 1 5 10 15 Leu Thr Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 468]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 468]]> Gly Ser Ala Pro Ala Ser Ser Arg Gly Glu Asn Pro Pro Pro Gly Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 469]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 469]]> Gly Ser Ala Pro Ala Ala Ser Arg Gly Thr Asn Thr Gly Pro Ala Glu 1 5 10 15 Leu Thr Gly Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 470]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 470]]> Gly Ser Ala Pro Ala Gly Ser Arg Thr Thr Asn Ala Gly Pro Gly Gly 1 5 10 15 Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 471]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 471]]> Gly Ser Ala Pro Ala Pro Ser Arg Gly Glu Asn Ala Gly Pro Ala Thr 1 5 10 15 Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 472]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 472]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Gly Pro Pro Thr 1 5 10 15 Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 473]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 473]]> Gly Ser Ala Pro Asn Pro Gly Arg Ala Ala Asn Glu Gly Pro Pro Gly 1 5 10 15 Leu Pro Gly Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 474]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 474]]> Gly Ser Ala Pro Glu Ser Ser Arg Ala Ala Asn Leu Thr Pro Pro Glu 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 475]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 475]]> Gly Ser Ala Pro Ala Ser Gly Arg Ala Ala Asn Glu Thr Pro Pro Gly 1 5 10 15 Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 476]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 476]]> Gly Ser Ala Pro Asn Ser Gly Arg Gly Glu Asn Leu Gly Ala Pro Gly 1 5 10 15 Leu Thr Gly Thr Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 477]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 477]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Ala Asn Leu Thr Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 478]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 478]]> Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 479]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 479]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Thr Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 480]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 480]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 481]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 481]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Glu Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 482]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 482]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 483]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 483]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Ala Asn Ala Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 484]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 484]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr 1 5 10 15 Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 485]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 485]]> Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Asn Ala Thr 1 5 10 15 Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 486]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 486]]> Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 487]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 487]]> Gly Ser Ala Pro Thr Thr Gly Ala Ala Gly Glu Ala Ala Asn Ala Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 488]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 488]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Gly Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 489]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 489]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Ala Thr 1 5 10 15 Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 490]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 490]]> Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Ala Thr 1 5 10 15 Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 491]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 491]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Glu Pro Pro Glu 1 5 10 15 Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 492]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 492]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn Thr Ala Pro Glu Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 493]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 493]]> Gly Ser Ala Pro Glu Pro Gly Arg Ala Ala Asn His Glu Pro Ser Gly 1 5 10 15 Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 494]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 494]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Pro 1 5 10 15 Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 495]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 495]]> Gly Ser Ala Pro Thr Thr Gly Arg Thr Gly Glu Gly Ala Asn Ala Thr 1 5 10 15 Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 496]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 496]]> Gly Ser Ala Pro Arg Thr Gly Arg Ser Gly Glu Ala Ala Asn Glu Thr 1 5 10 15 Pro Glu Gly Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 497]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 497]]> Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Ser Ala Asn Glu Thr 1 5 10 15 Pro Ala Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 498]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 498]]> Gly Ser Ala Pro Ser Thr Gly Arg Thr Gly Glu Pro Ala Asn Glu Thr 1 5 10 15 Pro Ala Gly Leu Ser Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 499]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 499]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Pro Ala Asn Ala Thr 1 5 10 15 Pro Thr Gly Leu Ser Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 500]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 500]]> Gly Ser Ala Pro Arg Thr Gly Arg Pro Gly Glu Gly Ala Asn Ala Thr 1 5 10 15 Pro Thr Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 501]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 501]]> Gly Ser Ala Pro Arg Thr Gly Arg Gly Gly Glu Ala Ala Asn Ala Thr 1 5 10 15 Pro Ser Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 502]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 502]]> Gly Ser Ala Pro Ser Thr Gly Arg Ser Gly Glu Ser Ala Asn Ala Thr 1 5 10 15 Pro Gly Gly Leu Gly Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 503]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 503]]> Gly Ser Ala Pro Arg Thr Gly Arg Thr Gly Glu Glu Ala Asn Ala Thr 1 5 10 15 Pro Ala Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 504]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 504]]> Gly Ser Ala Pro Ala Thr Gly Arg Pro Gly Glu Pro Ala Asn Thr Thr 1 5 10 15 Pro Glu Gly Leu Glu Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 505]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 505]]> Gly Ser Ala Pro Ser Thr Gly Arg Ser Gly Glu Pro Ala Asn Ala Thr 1 5 10 15 Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 506]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 506]]> Gly Ser Ala Pro Pro Thr Gly Arg Gly Gly Glu Gly Ala Asn Thr Thr 1 5 10 15 Pro Thr Gly Leu Pro Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 507]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 507]]> Gly Ser Ala Pro Pro Thr Gly Arg Ser Gly Glu Gly Ala Asn Ala Thr 1 5 10 15 Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 508]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 508]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Ser Glu Gly Ala Asn Ser Thr 1 5 10 15 Pro Ala Pro Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 509]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 509]]> Gly Ser Ala Pro Thr Tyr Gly Arg Ala Ala Glu Ala Ala Asn Thr Thr 1 5 10 15 Pro Ala Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 510]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 510]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Gly Ala Asn Ala Thr 1 5 10 15 Pro Ala Glu Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 511]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 511]]> Gly Ser Ala Pro Thr Val Gly Arg Ala Ser Glu Glu Ala Asn Thr Thr 1 5 10 15 Pro Ala Ser Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 512]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 512]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Pro Glu Ala Ala Asn Ala Thr 1 5 10 15 Pro Ala Pro Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 513]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 513]]> Gly Ser Ala Pro Thr Trp Gly Arg Ala Thr Glu Pro Ala Asn Ala Thr 1 5 10 15 Pro Ala Pro Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 514]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 514]]> Gly Ser Ala Pro Thr Val Gly Arg Ala Ser Glu Ser Ala Asn Ala Thr 1 5 10 15 Pro Ala Glu Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 515]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 515]]> Gly Ser Ala Pro Thr Val Gly Arg Ala Pro Glu Gly Ala Asn Ser Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 516]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 516]]> Gly Ser Ala Pro Thr Trp Gly Arg Ala Thr Glu Ala Pro Asn Leu Glu 1 5 10 15 Pro Ala Thr Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 517]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 517]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Thr Glu Ala Pro Asn Leu Thr 1 5 10 15 Pro Ala Pro Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 518]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 518]]> Gly Ser Ala Pro Thr Gln Gly Arg Ala Thr Glu Ala Pro Asn Leu Ser 1 5 10 15 Pro Ala Ala Leu Thr Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 519]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 519]]> Gly Ser Ala Pro Thr Gln Gly Arg Ala Ala Glu Ala Pro Asn Leu Thr 1 5 10 15 Pro Ala Thr Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 520]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 520]]> Gly Ser Ala Pro Thr Ser Gly Arg Ala Pro Glu Ala Thr Asn Leu Ala 1 5 10 15 Pro Ala Pro Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 521]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 521]]> Gly Ser Ala Pro Thr Gln Gly Arg Ala Ala Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 522]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 522]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Ser Ala Pro Asn Leu Pro 1 5 10 15 Pro Thr Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 523]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 523]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Glu Asn Leu Pro 1 5 10 15 Pro Glu Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 524]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 524]]> Gly Ser Ala Pro Thr Thr Ser Arg Ala Gly Thr Ala Thr Asn Leu Thr 1 5 10 15 Pro Glu Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 525]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 525]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro 1 5 10 15 Pro Ser Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 526]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 526]]> Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Glu Ala Glu Asn Leu Ser 1 5 10 15 Pro Ser Gly Leu Thr Ala Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 527]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 527]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Gly Asn Leu Ala 1 5 10 15 Pro Gly Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 528]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 528]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Thr Asn Leu Pro 1 5 10 15 Pro Glu Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 529]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 529]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Gly Ala Ala Asn Leu Ala 1 5 10 15 Pro Thr Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 530]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 530]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Thr Ala Glu Asn Leu Ala 1 5 10 15 Pro Ser Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 531]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 531]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Ser Ala Thr Asn Leu Gly 1 5 10 15 Pro Gly Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 532]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 532]]> Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Gly Ala Glu Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 533]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 533]]> Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Ser Ala Glu Asn Leu Ser 1 5 10 15 Pro Ser Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 534]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 534]]> Gly Ser Ala Pro Thr Thr Ala Arg Ala Gly Gly Ala Gly Asn Leu Ala 1 5 10 15 Pro Glu Gly Leu Thr Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 535]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 535]]> Gly Ser Ala Pro Thr Thr Ser Arg Ala Gly Ala Ala Glu Asn Leu Thr 1 5 10 15 Pro Thr Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 536]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 536]]> Gly Ser Ala Pro Thr Tyr Gly Arg Thr Thr Thr Pro Gly Asn Glu Pro 1 5 10 15 Pro Ala Ser Leu Glu Ala Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 537]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 537]]> Gly Ser Ala Pro Thr Tyr Ser Arg Gly Glu Ser Gly Pro Asn Glu Pro 1 5 10 15 Pro Pro Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 538]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 538]]> Gly Ser Ala Pro Ala Trp Gly Arg Thr Gly Ala Ser Glu Asn Glu Thr 1 5 10 15 Pro Ala Pro Leu Gly Gly Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 539]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 539]]> Gly Ser Ala Pro Arg Trp Gly Arg Ala Glu Thr Thr Pro Asn Thr Pro 1 5 10 15 Pro Glu Gly Leu Glu Thr Glu Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 540]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 540]]> Gly Ser Ala Pro Glu Ser Gly Arg Ala Ala Asn His Thr Gly Ala Glu 1 5 10 15 Pro Pro Glu Leu Gly Ala Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 541]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 541]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 542]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 542]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Ala Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 543]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 543]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Pro Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 544]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 544]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 545]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 545]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 546]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 546]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Gly Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 547]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 547]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Gly Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 548]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 548]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 549]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 549]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Gly Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 550]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 550]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Pro Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 551]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 551]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Glu Ala Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 552]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 552]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 553]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 553]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 554]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 554]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Gly Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 555]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 555]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Ala Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 556]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 556]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Gly Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 557]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 557]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 558]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 558]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Gly Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 559]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 559]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Ala Pro Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 560]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 560]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Ala Asn Leu Thr 1 5 10 15 Pro Glu Pro Leu Thr Glu Gly Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 561]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 561]]> Gly Ser Ala Pro Thr Thr Gly Arg Ala Gly Glu Ala Glu Gly Ala Thr 1 5 10 15 Ser Ala Gly Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 562]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 562]]> Gly Ser Ala Pro Glu Ala Gly Arg Ser Ala Glu Ala Thr Ser Ala Gly 1 5 10 15 Ala Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 563]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 563]]> Gly Ser Ala Pro Ser Ala Ser Gly Thr Tyr Ser Arg Gly Glu Ser Gly 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 564]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 564]]> Gly Ser Ala Pro Ser Ala Ser Gly Glu Ala Gly Arg Thr Asp Thr His 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 565]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 565]]> Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Gly Arg Ala Ala Glu His 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 566]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 566]]> Gly Ser Ala Pro Ser Pro Ala Gly Glu Ser Ser Arg Gly Thr Thr Ile 1 5 10 15 Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 567]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 567]]> Gly Ser Ala Pro Thr Thr Gly Glu Ala Gly Glu Ala Ala Gly Leu Thr 1 5 10 15 Pro Ala Gly Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 20 25 30 Thr <![CDATA[<210> 568]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 568]]> Gly Ser Ala Pro Glu Ala Gly Glu Ser Ala Gly Ala Thr Pro Ala Gly 1 5 10 15 Leu Thr Gly Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 569]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 569]]> Gly Ser Ala Pro Ser Ala Ser Gly Ala Pro Leu Glu Leu Glu Ala Gly 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 570]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 570]]> Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Pro Glu Leu Gly Ala Gly 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 571]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 571]]> Gly Ser Ala Pro Ser Ala Ser Gly Glu Pro Ser Gly Leu Thr Glu Gly 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 572]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 572]]> Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Pro Leu Thr Glu Pro 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 573]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 573]]> Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Glu Leu Thr Glu Pro 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 574]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 574]]> Gly Ser Ala Pro Ser Ala Ser Gly Pro Pro Pro Gly Leu Thr Gly Pro 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 575]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 575]]> Gly Ser Ala Pro Ser Ala Ser Gly Thr Pro Ala Pro Leu Gly Gly Glu 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 576]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 576]]> Gly Ser Ala Pro Ser Pro Ala Gly Ala Pro Glu Gly Leu Thr Gly Pro 1 5 10 15 Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 577]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 577]]> Gly Ser Ala Pro Ser Pro Ala Gly Pro Pro Glu Gly Leu Glu Thr Glu 1 5 10 15 Ala Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 578]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 578]]> Gly Ser Ala Pro Ser Pro Thr Ser Gly Gln Gly Gly Leu Thr Gly Pro 1 5 10 15 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 579]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 579]]> Gly Ser Ala Pro Ser Glu Ser Ala Pro Pro Glu Gly Leu Glu Thr Glu 1 5 10 15 Ser Thr Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 580]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 580]]> Gly Ser Ala Pro Ser Glu Gly Ser Glu Pro Leu Glu Leu Gly Ala Ala 1 5 10 15 Ser Glu Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 581]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 581]]> Gly Ser Ala Pro Ser Glu Gly Ser Gly Pro Ala Gly Leu Glu Ala Pro 1 5 10 15 Ser Glu Thr Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 582]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 582]]> Gly Ser Ala Pro Ser Glu Pro Thr Pro Pro Ala Ser Leu Glu Ala Glu 1 5 10 15 Pro Gly Ser Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 20 25 30 <![CDATA[<210> 583]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 583]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Ala Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 584]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 584]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Gly Gly Tyr 1 5 10 15 Ala Pro Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 585]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 585]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Glu Gly Gly Tyr 1 5 10 15 Ala Ala Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 586]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 586]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Pro Gly Gly Tyr 1 5 10 15 Ala Leu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 587]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 587]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Phe Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 588]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 588]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Ser Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 589]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 589]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Thr Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 590]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 590]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Asn Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 591]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 591]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala His Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 592]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 592]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Gly Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 593]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 593]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Pro Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 594]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 594]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Val Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 595]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 595]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Leu Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 596]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 596]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ser Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 597]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 597]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Thr Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 598]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 598]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Gln Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 599]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 599]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Glu Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 600]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 600]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Ile Gly Pro 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 601]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 601]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Ile Gly Ala 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 602]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 602]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Ile Gly Ser 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 603]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 603]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Ile Gly Thr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 604]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 604]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Ile Gly Asn 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 605]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 605]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Ile Gly Gln 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 606]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 606]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Pro Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 607]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 607]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Ala Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 608]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 608]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Val Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 609]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 609]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Leu Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 610]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 610]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Ile Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 611]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 611]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Phe Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 612]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 612]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Tyr Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 613]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 613]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Ser Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 614]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 614]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Asn Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 615]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 615]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Glu Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 616]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 616]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly His Tyr 1 5 10 15 Ala Glu Leu Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 617]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 617]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Ala Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 618]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 618]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Val Arg Met Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 619]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 619]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Ile Arg Met Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 620]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 620]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Phe Arg Met Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 621]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 621]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Tyr Arg Met Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 622]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 622]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Ser Arg Met Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 623]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 623]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Thr Arg Met Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 624]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 624]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Leu Ala Met Gly Gly Thr Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 625]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 625]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Leu Val Met Gly Gly Ala Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 626]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 626]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Leu Leu Met Gly Gly Gly Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 627]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 627]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Leu Ile Met Gly Gly Glu Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 628]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 628]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Leu Trp Met Gly Gly Pro Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 629]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 629]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Leu Ser Met Gly Gly Ser Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 630]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 630]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Leu Thr Met Gly Gly Thr Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 631]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 631]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Leu Gln Met Gly Gly Ala Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 632]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 632]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Leu Asn Met Gly Gly Gly Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 633]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 633]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Leu Glu Met Gly Gly Glu Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 634]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 634]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Pro Gly Gly Pro Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 635]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 635]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Ala Gly Gly Ser Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 636]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 636]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Leu Gly Gly Thr Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 637]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 637]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Ile Gly Gly Ala Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 638]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 638]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Ser Gly Gly Gly Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 639]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 639]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Asn Gly Gly Glu Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 640]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 640]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Gln Gly Gly Pro Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 641]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 641]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Asp Gly Gly Ser Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 642]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 642]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Glu Gly Gly Thr Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 643]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 643]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg His Gly Gly Ala Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 644]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 644]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Pro Gly Gly Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 645]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 645]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Ala Gly Glu Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 646]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 646]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Val Gly Pro Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 647]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 647]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Leu Gly Ser Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 648]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 648]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Ile Gly Thr Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 649]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 649]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Tyr Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 650]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 650]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Ser Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 651]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 651]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Asn Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 652]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 652]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Tyr 1 5 10 15 Ala Glu Leu Arg Met Gln Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 653]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 653]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn His Thr Pro 1 5 10 15 Ala Gly Leu Thr Gly Pro Gly Ala Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 654]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 654]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn Thr Ala Pro 1 5 10 15 Glu Gly Leu Thr Gly Pro Ser Thr Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 655]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 655]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Ala Pro Pro 1 5 10 15 Gly Gly Leu Thr Gly Pro Gly Thr Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 656]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 656]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn His Glu Pro 1 5 10 15 Ser Gly Leu Thr Glu Gly Ser Pro Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 657]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 657]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Asn Thr Glu Pro 1 5 10 15 Pro Glu Leu Gly Ala Gly Thr Glu Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 658]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 658]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Pro Pro 1 5 10 15 Pro Gly Leu Thr Gly Pro Pro Gly Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 659]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 659]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Thr Pro 1 5 10 15 Ala Pro Leu Gly Gly Glu Pro Gly Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 660]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 660]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Ala Gly Pro Pro 1 5 10 15 Glu Gly Leu Glu Thr Glu Ala Gly Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 661]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 661]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Thr Ser Gly Gln 1 5 10 15 Gly Gly Leu Thr Gly Pro Glu Ser Arg Pro Gly Ser Pro 20 25 <![CDATA[<210> 662]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 662]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Ala Gly Gly Ala 1 5 10 15 Ala Asn Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 663]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 663]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Gly Gly Gly Ala 1 5 10 15 Ala Pro Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 664]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 664]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Glu Gly Gly Ala 1 5 10 15 Ala Ala Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 665]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 665]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Pro Gly Gly Ala 1 5 10 15 Ala Leu Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 666]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 666]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala 1 5 10 15 Ala Phe Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 667]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 667]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Ala 1 5 10 15 Ala Ser Leu Val Arg Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 668]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 668]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Ala 1 5 10 15 Ala Thr Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 669]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 669]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Ala 1 5 10 15 Ala Gly Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 670]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 670]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Ala 1 5 10 15 Ala Asp Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 671]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 671]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Ala 1 5 10 15 Gly Asn Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 672]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 672]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala 1 5 10 15 Pro Asn Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 673]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 673]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Pro Gly Gly Gly Ala 1 5 10 15 Val Asn Leu Val Arg Gly Gly Thr Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 674]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 674]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ser Glu Gly Gly Ala 1 5 10 15 Leu Asn Leu Val Arg Gly Gly Ala Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 675]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 675]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr Pro Gly Gly Ala 1 5 10 15 Ser Asn Leu Val Arg Gly Gly Gly Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 676]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 676]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Ser Gly Gly Ala 1 5 10 15 Thr Asn Leu Val Arg Gly Gly Glu Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 677]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 677]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Gly Thr Gly Gly Ala 1 5 10 15 Gln Asn Leu Val Arg Gly Gly Pro Ala Pro Gly Ser Pro 20 25 <![CDATA[<210> 678]]> <![CDATA[<211> 29]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 678]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Glu Ala Gly Gly Ala 1 5 10 15 Glu Asn Leu Val Arg Gly Gly Ser Ile Pro Gly Ser Pro 20 25 <![CDATA[<210> 679]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 679]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala 1 5 10 15 Asn His Glu Pro Leu Gly Leu Val Ala Thr Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 680]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 680]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr 1 5 10 15 Asn Ala Gly Pro Ser Gly Leu Ala Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 681]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 681]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr 1 5 10 15 Asn Ala Gly Pro Gln Gly Leu Ala Gly Gln Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 682]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 682]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ser Thr 1 5 10 15 Asn Ala Gly Pro Pro Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 683]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 683]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Thr 1 5 10 15 Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 684]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 684]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Thr Thr 1 5 10 15 Asn Thr Gly Pro Ser Thr Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 685]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 685]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ala Gly Arg Ser Asp 1 5 10 15 Asn Gly Thr Pro Leu Glu Leu Val Ala Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 686]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 686]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala 1 5 10 15 Asn His Glu Pro Leu Gly Leu Val Ala Thr Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 687]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 687]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Gly Thr 1 5 10 15 Asn Ala Gly Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 688]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 688]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Phe Gly Arg Asn Asp 1 5 10 15 Asn His Glu Pro Leu Glu Leu Gly Gly Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 689]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 689]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Ala Gly Arg Ser Asp 1 5 10 15 Asn Leu Glu Pro Leu Gly Leu Val Phe Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 690]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 690]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Asp Gly Arg Ser Asp 1 5 10 15 Asn Phe His Pro Pro Glu Leu Val Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 691]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 691]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Glu Gly Arg Ser Asp 1 5 10 15 Asn Glu Glu Pro Glu Asn Leu Val Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 692]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 692]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Lys Gly Arg Ser Asp 1 5 10 15 Asn Asn Ala Pro Leu Ala Leu Val Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 693]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 693]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Val Tyr Ser Arg Gly Thr 1 5 10 15 Asn Ala Gly Pro His Gly Leu Thr Gly Arg Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 694]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 694]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Asn Ser Arg Gly Thr 1 5 10 15 Asn Lys Gly Phe Ala Gly Leu Ile Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 695]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 695]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Leu Thr 1 5 10 15 Asn Glu Ala Pro Ala Gly Leu Thr Ile Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 696]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 696]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asp Gln Ser Arg Gly Thr 1 5 10 15 Asn Ala Gly Pro Glu Gly Leu Thr Asp Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 697]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 697]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Gly Thr 1 5 10 15 Asn Ile Gly Gln Gly Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 698]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 698]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ser Ser Arg Gly Thr 1 5 10 15 Asn Gln Asp Pro Ala Gly Leu Thr Ile Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 699]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 699]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Gln 1 5 10 15 Asn His Ser Pro Met Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 700]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 700]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Tyr Ser Arg Gly Pro 1 5 10 15 Asn Ala Gly Pro Ala Gly Leu Glu Gly Arg Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 701]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 701]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Glu Arg Gly Asn 1 5 10 15 Asn Ala Gly Pro Ala Asn Leu Thr Gly Phe Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 702]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 702]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser His Arg Gly Thr 1 5 10 15 Asn Pro Lys Pro Ala Ile Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 703]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 703]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Met Ser Ser Arg Arg Thr 1 5 10 15 Asn Ala Asn Pro Ala Gln Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 704]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 704]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Ala Gly Arg Thr Asp 1 5 10 15 Asn His Glu Pro Leu Glu Leu Gly Ala Ala Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 705]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 705]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ala Gly Arg Ser Glu 1 5 10 15 Asn Thr Ala Pro Leu Glu Leu Thr Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 706]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 706]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Glu Gly Arg Pro Asp 1 5 10 15 Asn His Glu Pro Leu Ala Leu Val Ala Ser Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 707]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 707]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ser Gly Arg Ser Asp 1 5 10 15 Asn Glu Glu Pro Leu Ala Leu Pro Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 708]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 708]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Thr Asp 1 5 10 15 Asn His Glu Pro Leu Glu Leu Ser Ala Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 709]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 709]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Gly Gly Arg Ser Asp 1 5 10 15 Asn His Gly Pro Leu Glu Leu Val Ser Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 710]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 710]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Ser Gly Arg Ser Asp 1 5 10 15 Asn Glu Ala Pro Leu Glu Leu Glu Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 711]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 711]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Leu Gly Gly Arg Ala Asp 1 5 10 15 Asn His Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 712]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 712]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Pro Ser Arg Gly Thr 1 5 10 15 Asn Ala Glu Pro Ala Gly Leu Thr Gly Glu Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 713]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 713]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Thr Arg Gly Glu 1 5 10 15 Asn Ala Gly Pro Ala Gly Leu Glu Ala Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 714]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 714]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Gly Thr 1 5 10 15 Asn Gly Ala Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 715]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 715]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Ala Thr 1 5 10 15 Asn Glu Ser Pro Ala Gly Leu Thr Gly Glu Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 716]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 716]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Ser Arg Gly Glu 1 5 10 15 Asn Pro Pro Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 717]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 717]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ala Ser Arg Gly Thr 1 5 10 15 Asn Thr Gly Pro Ala Glu Leu Thr Gly Ser Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 718]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 718]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Gly Ser Arg Thr Thr 1 5 10 15 Asn Ala Gly Pro Gly Gly Leu Glu Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 719]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 719]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Pro Ser Arg Gly Glu 1 5 10 15 Asn Ala Gly Pro Ala Thr Leu Thr Gly Ala Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 720]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 720]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn Thr Gly Pro Pro Thr Leu Thr Ala Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 721]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 721]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asn Pro Gly Arg Ala Ala 1 5 10 15 Asn Glu Gly Pro Pro Gly Leu Pro Gly Ser Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 722]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 722]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Ser Arg Ala Ala 1 5 10 15 Asn Leu Thr Pro Pro Glu Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 723]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 723]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Ser Gly Arg Ala Ala 1 5 10 15 Asn Glu Thr Pro Pro Gly Leu Thr Gly Ala Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 724]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 724]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Asn Ser Gly Arg Gly Glu 1 5 10 15 Asn Leu Gly Ala Pro Gly Leu Thr Gly Thr Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 725]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 725]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Ala 1 5 10 15 Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 726]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 726]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala 1 5 10 15 Asn His Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 727]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 727]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn Thr Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 728]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 728]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 729]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 729]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Glu 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 730]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 730]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 731]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 731]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr 1 5 10 15 Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 732]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 732]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 733]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 733]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly 1 5 10 15 Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 734]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 734]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly 1 5 10 15 Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 735]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 735]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Ala Ala Gly 1 5 10 15 Glu Ala Ala Asn Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 736]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 736]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 737]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 737]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 738]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 738]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly 1 5 10 15 Glu Ala Ala Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 739]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 739]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn Thr Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 740]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 740]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn Thr Ala Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 741]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 741]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Pro Gly Arg Ala Ala 1 5 10 15 Asn His Glu Pro Ser Gly Leu Thr Glu Gly Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 742]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 742]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn His Thr Gly Ala Pro Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 743]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 743]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Thr Gly 1 5 10 15 Glu Gly Ala Asn Ala Thr Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 744]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 744]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Ser Gly 1 5 10 15 Glu Ala Ala Asn Glu Thr Pro Glu Gly Leu Glu Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 745]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 745]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly 1 5 10 15 Glu Ser Ala Asn Glu Thr Pro Ala Gly Leu Gly Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 746]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 746]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Thr Gly Arg Thr Gly 1 5 10 15 Glu Pro Ala Asn Glu Thr Pro Ala Gly Leu Ser Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 747]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 747]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Pro Ala Asn Ala Thr Pro Thr Gly Leu Ser Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 748]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 748]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Pro Gly 1 5 10 15 Glu Gly Ala Asn Ala Thr Pro Thr Gly Leu Pro Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 749]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 749]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Gly Gly 1 5 10 15 Glu Ala Ala Asn Ala Thr Pro Ser Gly Leu Gly Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 750]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 750]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Thr Gly Arg Ser Gly 1 5 10 15 Glu Ser Ala Asn Ala Thr Pro Gly Gly Leu Gly Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 751]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 751]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Thr Gly Arg Thr Gly 1 5 10 15 Glu Glu Ala Asn Ala Thr Pro Ala Gly Leu Pro Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 752]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 752]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Thr Gly Arg Pro Gly 1 5 10 15 Glu Pro Ala Asn Thr Thr Pro Glu Gly Leu Glu Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 753]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 753]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Thr Gly Arg Ser Gly 1 5 10 15 Glu Pro Ala Asn Ala Thr Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 754]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 754]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Thr Gly Arg Gly Gly 1 5 10 15 Glu Gly Ala Asn Thr Thr Pro Thr Gly Leu Pro Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 755]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 755]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Pro Thr Gly Arg Ser Gly 1 5 10 15 Glu Gly Ala Asn Ala Thr Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 756]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 756]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Ser 1 5 10 15 Glu Gly Ala Asn Ser Thr Pro Ala Pro Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 757]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 757]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Gly Arg Ala Ala 1 5 10 15 Glu Ala Ala Asn Thr Thr Pro Ala Gly Leu Thr Ala Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 758]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 758]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr 1 5 10 15 Glu Gly Ala Asn Ala Thr Pro Ala Glu Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 759]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 759]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Ser 1 5 10 15 Glu Glu Ala Asn Thr Thr Pro Ala Ser Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 760]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 760]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Pro 1 5 10 15 Glu Ala Ala Asn Ala Thr Pro Ala Pro Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 761]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 761]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Trp Gly Arg Ala Thr 1 5 10 15 Glu Pro Ala Asn Ala Thr Pro Ala Pro Leu Thr Ser Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 762]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 762]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Ser 1 5 10 15 Glu Ser Ala Asn Ala Thr Pro Ala Glu Leu Thr Ser Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 763]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 763]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Val Gly Arg Ala Pro 1 5 10 15 Glu Gly Ala Asn Ser Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 764]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 764]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Trp Gly Arg Ala Thr 1 5 10 15 Glu Ala Pro Asn Leu Glu Pro Ala Thr Leu Thr Thr Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 765]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 765]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Thr 1 5 10 15 Glu Ala Pro Asn Leu Thr Pro Ala Pro Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 766]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 766]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Thr 1 5 10 15 Glu Ala Pro Asn Leu Ser Pro Ala Ala Leu Thr Ser Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 767]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 767]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Ala 1 5 10 15 Glu Ala Pro Asn Leu Thr Pro Ala Thr Leu Thr Ala Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 768]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 768]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Ser Gly Arg Ala Pro 1 5 10 15 Glu Ala Thr Asn Leu Ala Pro Ala Pro Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 769]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 769]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Gln Gly Arg Ala Ala 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 770]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 770]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Ser Ala Pro Asn Leu Pro Pro Thr Gly Leu Thr Thr Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 771]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 771]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Gly Ala Glu Asn Leu Pro Pro Glu Gly Leu Thr Ala Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 772]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 772]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ser Arg Ala Gly 1 5 10 15 Thr Ala Thr Asn Leu Thr Pro Glu Gly Leu Thr Ala Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 773]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 773]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Thr Ala Thr Asn Leu Pro Pro Ser Gly Leu Thr Thr Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 774]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 774]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly 1 5 10 15 Glu Ala Glu Asn Leu Ser Pro Ser Gly Leu Thr Ala Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 775]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 775]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Gly Ala Gly Asn Leu Ala Pro Gly Gly Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 776]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 776]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Thr Ala Thr Asn Leu Pro Pro Glu Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 777]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 777]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Gly Ala Ala Asn Leu Ala Pro Thr Gly Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 778]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 778]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Thr Ala Glu Asn Leu Ala Pro Ser Gly Leu Thr Thr Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 779]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 779]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Ser Ala Thr Asn Leu Gly Pro Gly Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 780]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 780]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly 1 5 10 15 Gly Ala Glu Asn Leu Thr Pro Ala Gly Leu Thr Glu Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 781]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 781]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly 1 5 10 15 Ser Ala Glu Asn Leu Ser Pro Ser Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 782]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 782]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ala Arg Ala Gly 1 5 10 15 Gly Ala Gly Asn Leu Ala Pro Glu Gly Leu Thr Thr Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 783]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 783]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Ser Arg Ala Gly 1 5 10 15 Ala Ala Glu Asn Leu Thr Pro Thr Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 784]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 784]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Gly Arg Thr Thr 1 5 10 15 Thr Pro Gly Asn Glu Pro Pro Ala Ser Leu Glu Ala Glu Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 785]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 785]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Tyr Ser Arg Gly Glu 1 5 10 15 Ser Gly Pro Asn Glu Pro Pro Pro Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 786]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 786]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ala Trp Gly Arg Thr Gly 1 5 10 15 Ala Ser Glu Asn Glu Thr Pro Ala Pro Leu Gly Gly Glu Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 787]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 787]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Trp Gly Arg Ala Glu 1 5 10 15 Thr Thr Pro Asn Thr Pro Pro Glu Gly Leu Glu Thr Glu Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 788]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 788]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ser Gly Arg Ala Ala 1 5 10 15 Asn His Thr Gly Ala Glu Pro Pro Glu Leu Gly Ala Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 789]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 789]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Ser Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 790]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 790]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Ala Leu Thr Glu Ser Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 791]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 791]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Ser Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 792]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 792]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Ser Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 793]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 793]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 794]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 794]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Gly Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 795]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 795]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 796]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 796]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 797]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 797]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Glu Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 798]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 798]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 799]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 799]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Ala Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 800]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 800]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 801]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 801]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Gly Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 802]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 802]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Gly Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 803]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 803]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Ala Leu Thr Gly Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 804]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 804]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Gly Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 805]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 805]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Gly Leu Thr Glu Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 806]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 806]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Gly Leu Thr Glu Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 807]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 807]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Ala Pro Leu Thr Glu Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 808]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 808]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Ala Asn Leu Thr Pro Glu Pro Leu Thr Glu Gly Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 809]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 809]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Arg Ala Gly 1 5 10 15 Glu Ala Glu Gly Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 810]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 810]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala 1 5 10 15 Glu Ala Thr Ser Ala Gly Ala Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 811]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 811]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Tyr 1 5 10 15 Ser Arg Gly Glu Ser Gly Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 812]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 812]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Ala 1 5 10 15 Gly Arg Thr Asp Thr His Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 813]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 813]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro 1 5 10 15 Gly Arg Ala Ala Glu His Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 814]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 814]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Glu Ser 1 5 10 15 Ser Arg Gly Thr Thr Ile Ala Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 815]]> <![CDATA[<211> 33]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 815]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Thr Thr Gly Glu Ala Gly 1 5 10 15 Glu Ala Ala Gly Leu Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser 20 25 30 Pro <![CDATA[<210> 816]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 816]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Glu Ser Ala 1 5 10 15 Gly Ala Thr Pro Ala Gly Leu Thr Gly Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 817]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 817]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Ala Pro 1 5 10 15 Leu Glu Leu Glu Ala Gly Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 818]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 818]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro 1 5 10 15 Pro Glu Leu Gly Ala Gly Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 819]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 819]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Glu Pro 1 5 10 15 Ser Gly Leu Thr Glu Gly Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 820]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 820]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro 1 5 10 15 Ala Pro Leu Thr Glu Pro Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 821]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 821]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro 1 5 10 15 Ala Glu Leu Thr Glu Pro Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 822]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 822]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Pro Pro 1 5 10 15 Pro Gly Leu Thr Gly Pro Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 823]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 823]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Ala Ser Gly Thr Pro 1 5 10 15 Ala Pro Leu Gly Gly Glu Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 824]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 824]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Ala Pro 1 5 10 15 Glu Gly Leu Thr Gly Pro Ala Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 825]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 825]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Ala Gly Pro Pro 1 5 10 15 Glu Gly Leu Glu Thr Glu Ala Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 826]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 826]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Pro Thr Ser Gly Gln 1 5 10 15 Gly Gly Leu Thr Gly Pro Gly Ser Glu Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 827]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 827]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Ser Ala Pro Pro 1 5 10 15 Glu Gly Leu Glu Thr Glu Ser Thr Glu Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 828]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 828]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Gly Ser Glu Pro 1 5 10 15 Leu Glu Leu Gly Ala Ala Ser Glu Thr Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 829]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 829]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Gly Ser Gly Pro 1 5 10 15 Ala Gly Leu Glu Ala Pro Ser Glu Thr Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 830]]> <![CDATA[<211> 30]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 830]]> Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Ser Glu Pro Thr Pro Pro 1 5 10 15 Ala Ser Leu Glu Ala Glu Pro Gly Ser Pro Pro Gly Ser Pro 20 25 30 <![CDATA[<210> 831]]> <![CDATA[<211> 4134]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 831]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgtgctgcag 1560 agcccaggta cctcagagtc tgctaccccc gagtcagggc caggatcaga gccagccacc 1620 tccgggtctg agacacccgg gacttccgag agtgccaccc ctgagtccgg acccgggtcc 1680 gagcccgcca cttccggctc cgaaactccc ggcacaagcg agagcgctac cccagagtca 1740 ggaccaggaa catctacaga gccctctgaa ggctccgctc cagggtcccc agccggcagt 1800 cccactagca ccgaggaggg aacctctgaa agcgccacac ccgaatcagg gccagggtct 1860 gagcctgcta ccagcggcag cgagacacca ggcacctctg agtccgccac accagagtcc 1920 ggacccggat ctcccgctgg gagccccacc tccactgagg agggatctcc tgctggctct 1980 ccaacatcta ctgaggaagg tacctcaacc gagccatccg agggatcagc tcccggcacc 2040 tcagagtcgg caaccccgga gtctggaccc ggaacttccg aaagtgccac accagagtcc 2100 ggtcccggga cttcagaatc agcaacaccc gagtccggcc ctgggtctga acccgccaca 2160 agtggtagtg agacaccagg atcagaacct gctacctcag ggtcagagac acccggatct 2220 ccggcaggct caccaacctc cactgaggag ggcaccagca cagaaccaag cgagggctcc 2280 gcacccggaa caagcactga acccagtgag ggttcagcac ccggctctga gccggccaca 2340 agtggcagtg agacacccgg cacttcagag agtgccaccc ccgagagtgg cccaggcact 2400 agtaccgagc cctctgaagg cagtgcgcca gagatcgtcc tgacccaatc ccccgggacc 2460 ctcagcctga gcccaggcga gcgtgccact ttgagctgtc gtgcatcaca gagtgtgagt 2520 tcctcattcc tggcttggta ccagcaaaag cccggtcagg ccccgagact tttgatttac 2580 tatgcttcca gccgcgctac cgggatccca gatagatttt ctgggagcgg ttctggtacc 2640 gatttcactc tgaccatctc tagactcgaa ccagaagact ttgcagtata ttactgccaa 2700 cagaccggtc ggatccctcc aactttcgga cagggtacca aggttgagat caagggtgca 2760 acgcctccgg agactggtgc tgaaactgag tccccgggcg agacgaccgg tggctctgct 2820 gaatccgaac caccgggcga aggcgaggtc cagctgttgg agagcggcgg tggactcgtg 2880 cagccgggcg gttcacttcg tctcagttgt gctgcctcag gcttcacctt tagctcattc 2940 tcaatgagtt gggtgagaca ggcgcccggc aagggccttg agtgggttag ttccatttcc 3000 ggctccagcg gcactaccta ctatgccgac tcagtcaaag gtagatttac catctcccgc 3060 gataactcta agaacaccct gtacctgcag atgaactccc tcagggcaga ggataccgcc 3120 gtgtactatt gcgcgaagcc cttcccatac ttcgactact ggggtcaggg caccctggtc 3180 actgtcagtt ccggcacagc cgaggccgct agcgccagcg gcgaggccgg ccggagcgcc 3240 aaccacaccc ccgccggcct gaccggccct ggttctcctg ctggctcccc cacctcaaca 3300 gaagagggga caagcgaaag cgctacgcct gagagtggcc ctggctctga gccagccacc 3360 tccggctctg aaacccctgg cactagtgag tctgccacgc ctgagtccgg acccgggacc 3420 tctactgagc cctcggaggg gagcgctcct ggcacgagta cagaaccttc cgaaggaagt 3480 gcaccgggca caagcaccga gccttccgaa ggctctgctc ccggaacctc taccgaaccc 3540 tctgaagggt ctgcacccgg cacgagcacc gaacccagcg aagggtcagc gcctgggacc 3600 tcaacagagc cctcggaagg atcagcgcct ggaagccctg cagggagtcc aacttccacg 3660 gaagaaggaa cgtctacaga gccatcagag gggtccgcac caggtaccag cgaatccgct 3720 actcccgaat ctggccctgg gtccgaacct gccacctccg gctctgaaac tccagggacc 3780 tccgaatctg ccacacccga gagcggccct ggctccgagc ccgcaacatc tggcagcgag 3840 acacctggca cctccgagag cgcaacaccc gagagcggcc ctggcaccag caccgagcca 3900 tccgagggat ccgccccagg cacttctgag tcagccacac ccgaaagcgg accaggatca 3960 cccgctggct cccccaccag taccgaggag gggtcccccg ctggaagtcc aacaagcact 4020 gaggaagggt cccctgccgg ctcccccaca agtaccgaag agggcacaag tgagagcgcc 4080 actcccgagt ccgggcctgg caccagcaca gagccttccg aggggtccgc acca 4134 <![CDATA[<210> 832]]> <![CDATA[<211> 3609]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 832]]> atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg actggacacc agatgccccc 60 ggcgagaccg tgaacctgac atgcgacacc cccgaggagg acgatatcac ctggacatct 120 gatcagaggc acggcgtgat cggaagcggc aagaccctga caatcaccgt gaaggagttc 180 ctggatgccg gccagtacac atgtcacaag ggcggcgaga ccctgtccca ctctcacctg 240 ctgctgcaca agaaggagaa cggcatctgg tccacagaga tcctgaagaa cttcaagaat 300 aagacctttc tgaagtgcga ggcccctaat tatagcggcc ggttcacctg ttcctggctg 360 gtgcagagaa acatggacct gaagtttaat atcaagagct cctctagctc cccagatagc 420 cgggcagtga catgcggaat ggccagcctg tccgccgaga aggtgaccct ggaccagaga 480 gattacgaga agtattctgt gagctgccag gaggacgtga catgtcccac cgccgaggag 540 acactgccta tcgagctggc cctggaggcc aggcagcaga acaagtacga gaattattcc 600 acctctttct ttatccgcga catcatcaag ccagatcccc ctaagaacct gcagatgaag 660 cccctgaaga attcccaggt cgaggtgtct tgggagtacc ctgacagctg gtccacacca 720 cactcttatt tcagcctgaa gttctttgtg aggatccagc gcaagaagga gaagatgaag 780 gagaccgagg agggctgcaa tcagaagggc gcctttctgg tggagaagac atccaccgag 840 gtgcagtgca agggaggaaa cgtgtgcgtg caggcacagg atcggtacta taattctagc 900 tgttccaagt gggcctgcgt gccttgtcgg gtgagatctg gcacagccga ggccgctagc 960 gccagcggcg aggccggccg gagcgccaac cacacccccg ccggcctgac cggccctggt 1020 tctccagccg ggtccccaac ttcgaccgag gaagggacct ccgagtcagc taccccggag 1080 tccggtcctg gcacctccac cgaaccatcg gagggcagcg cccctgggag ccctgccggg 1140 agccctacaa gcaccgaaga gggcaccagt acagagccaa gtgaggggag cgcccctggt 1200 actagtactg aaccatccga ggggtcagct ccaggcacga gtgagtccgc tacccccgag 1260 agcggaccgg gctcagagcc cgccacgagt ggcagtgaaa ctccaggctc agaacccgcc 1320 actagtgggt cagagactcc aggcagccct gccggatccc ctacgtccac cgaggaggga 1380 acatctgagt ccgcaacacc cgaatccggt ccaggcacct ccacggaacc tagtgaaggc 1440 tcggcaccag gtacaagcac cgaacctagc gagggcagcg ctcccggcag ccctgccggc 1500 agcccaacct caactgagga gggcaccagt actgagccca gcgagggatc agcacctggc 1560 accagcaccg aacctagcga ggggagcgcc cctgggacta gcgagtcagc tacaccagag 1620 agcgggcctg gaacttctac cgaacccagt gagggatccg ctccaggcac ctccgaatcc 1680 gcaacccccg aatccggacc tggctcagag cccgccacca gcgggagcga aacccctggc 1740 acatccaccg agcctagcga agggtccgca cccggcacca gtacagagcc tagcgaggga 1800 tcagcacctg gcaccagtga atctgctaca ccagagagcg gccctggaac ctccgagtcc 1860 gctacccccg agagcgggcc aggttctcct gctggctccc ccacctcaac agaagagggg 1920 acaagcgaaa gcgctacgcc tgagagtggc cctggctctg agccagccac ctccggctct 1980 gaaacccctg gcactagtga gtctgccacg cctgagtccg gacccgggac ctctactgag 2040 ccctcggagg ggagcgctcc tggcacgagt acagaacctt ccgaaggaag tgcaccgggc 2100 acaagcaccg agccttccga aggctctgct cccggaacct ctaccgaacc ctctgaaggg 2160 tctgcacccg gcacgagcac cgaacccagc gaagggtcag cgcctgggac ctcaacagag 2220 ccctcggaag gatcagcgcc tggaagccct gcagggagtc caacttccac ggaagaagga 2280 acgtctacag agccatcaga ggggtccgca ccaggtacca gcgaatccgc tactcccgaa 2340 tctggccctg ggtccgaacc tgccacctcc ggctctgaaa ctccagggac ctccgaatct 2400 gccacacccg agagcggccc tggctccgag cccgcaacat ctggcagcga gacacctggc 2460 acctccgaga gcgcaacacc cgagagcggc cctggcacca gcaccgagcc atccgaggga 2520 tccgccccag gcacttctga gtcagccaca cccgaaagcg gaccaggatc acccgctggc 2580 tcccccacca gtaccgagga ggggtccccc gctggaagtc caacaagcac tgaggaaggg 2640 tcccctgccg gctcccccac aagtaccgaa gagggcacaa gtgagagcgc cactcccgag 2700 tccgggcctg gcaccagcac agagccttcc gaggggtccg caccaggtac ctcagagtct 2760 gctacccccg agtcagggcc aggatcagag ccagccacct ccgggtctga gacacccggg 2820 acttccgaga gtgccacccc tgagtccgga cccgggtccg agcccgccac ttccggctcc 2880 gaaactcccg gcacaagcga gagcgctacc ccagagtcag gaccaggaac atctacagag 2940 ccctctgaag gctccgctcc agggtcccca gccggcagtc ccactagcac cgaggaggga 3000 acctctgaaa gcgccacacc cgaatcaggg ccagggtctg agcctgctac cagcggcagc 3060 gagacaccag gcacctctga gtccgccaca ccagagtccg gacccggatc tcccgctggg 3120 agccccacct ccactgagga gggatctcct gctggctctc caacatctac tgaggaaggt 3180 acctcaaccg agccatccga gggatcagct cccggcacct cagagtcggc aaccccggag 3240 tctggacccg gaacttccga aagtgccaca ccagagtccg gtcccgggac ttcagaatca 3300 gcaacacccg agtccggccc tgggtctgaa cccgccacaa gtggtagtga gacaccagga 3360 tcagaacctg ctacctcagg gtcagagaca cccggatctc cggcaggctc accaacctcc 3420 actgaggagg gcaccagcac agaaccaagc gagggctccg cacccggaac aagcactgaa 3480 cccagtgagg gttcagcacc cggctctgag ccggccacaa gtggcagtga gacacccggc 3540 acttcagaga gtgccacccc cgagagtggc ccaggcacta gtaccgagcc ctctgaaggc 3600 agtgcgcca 3609 <![CDATA[<210> 833]]> <![CDATA[<211> 2562]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 833]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gaggccggcc ggagcgccaa ccacaccccc gccggcctga ccggccctgg cacagccgag 660 gccgctagcg ccagcggcat gtgggagctg gagaaggacg tgtacgtggt ggaggtggac 720 tggacaccag atgcccccgg cgagaccgtg aacctgacat gcgacacccc cgaggaggac 780 gatatcacct ggacatctga tcagaggcac ggcgtgatcg gaagcggcaa gaccctgaca 840 atcaccgtga aggagttcct ggatgccggc cagtacacat gtcacaaggg cggcgagacc 900 ctgtcccact ctcacctgct gctgcacaag aaggagaacg gcatctggtc cacagagatc 960 ctgaagaact tcaagaataa gacctttctg aagtgcgagg cccctaatta tagcggccgg 1020 ttcacctgtt cctggctggt gcagagaaac atggacctga agtttaatat caagagctcc 1080 tctagctccc cagatagccg ggcagtgaca tgcggaatgg ccagcctgtc cgccgagaag 1140 gtgaccctgg accagagaga ttacgagaag tattctgtga gctgccagga ggacgtgaca 1200 tgtcccaccg ccgaggagac actgcctatc gagctggccc tggaggccag gcagcagaac 1260 aagtacgaga attattccac ctctttcttt atccgcgaca tcatcaagcc agatccccct 1320 aagaacctgc agatgaagcc cctgaagaat tcccaggtcg aggtgtcttg ggagtaccct 1380 gacagctggt ccacaccaca ctcttatttc agcctgaagt tctttgtgag gatccagcgc 1440 aagaaggaga agatgaagga gaccgaggag ggctgcaatc agaagggcgc ctttctggtg 1500 gagaagacat ccaccgaggt gcagtgcaag ggaggaaacg tgtgcgtgca ggcacaggat 1560 cggtactata attctagctg ttccaagtgg gcctgcgtgc cttgtcgggt gagatctggc 1620 acagccgagg ccgctagcgc cagcggcgag gccggccgga gcgccaacca cacccccgcc 1680 ggcctgaccg gccctggtac ctcagagtct gctacccccg agtcagggcc aggatcagag 1740 ccagccacct ccgggtctga gacacccggg acttccgaga gtgccacccc tgagtccgga 1800 cccgggtccg agcccgccac ttccggctcc gaaactcccg gcacaagcga gagcgctacc 1860 ccagagtcag gaccaggaac atctacagag ccctctgaag gctccgctcc agggtcccca 1920 gccggcagtc ccactagcac cgaggaggga acctctgaaa gcgccacacc cgaatcaggg 1980 ccagggtctg agcctgctac cagcggcagc gagacaccag gcacctctga gtccgccaca 2040 ccagagtccg gacccggatc tcccgctggg agccccacct ccactgagga gggatctcct 2100 gctggctctc caacatctac tgaggaaggt acctcaaccg agccatccga gggatcagct 2160 cccggcacct cagagtcggc aaccccggag tctggacccg gaacttccga aagtgccaca 2220 ccagagtccg gtcccgggac ttcagaatca gcaacacccg agtccggccc tgggtctgaa 2280 cccgccacaa gtggtagtga gacaccagga tcagaacctg ctacctcagg gtcagagaca 2340 cccggatctc cggcaggctc accaacctcc actgaggagg gcaccagcac agaaccaagc 2400 gagggctccg cacccggaac aagcactgaa cccagtgagg gttcagcacc cggctctgag 2460 ccggccacaa gtggcagtga gacacccggc acttcagaga gtgccacccc cgagagtggc 2520 ccaggcacta gtaccgagcc ctctgaaggc agtgcgccac at 2562 <![CDATA[<210> 834]]> <![CDATA[<211> 3087]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 834]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccaggttct cctgctggct cccccacctc aacagaagag 900 gggacaagcg aaagcgctac gcctgagagt ggccctggct ctgagccagc cacctccggc 960 tctgaaaccc ctggcactag tgagtctgcc acgcctgagt ccggacccgg gacctctact 1020 gagccctcgg aggggagcgc tcctggcacg agtacagaac cttccgaagg aagtgcaccg 1080 ggcacaagca ccgagccttc cgaaggctct gctcccggaa cctctaccga ggccggccgg 1140 agcgccaacc acacccccgc cggcctgacc ggccctggca cagccgaggc cgctagcgcc 1200 agcggcatgt gggagctgga gaaggacgtg tacgtggtgg aggtggactg gacaccagat 1260 gcccccggcg agaccgtgaa cctgacatgc gacacccccg aggaggacga tatcacctgg 1320 acatctgatc agaggcacgg cgtgatcgga agcggcaaga ccctgacaat caccgtgaag 1380 gagttcctgg atgccggcca gtacacatgt cacaagggcg gcgagaccct gtcccactct 1440 cacctgctgc tgcacaagaa ggagaacggc atctggtcca cagagatcct gaagaacttc 1500 aagaataaga cctttctgaa gtgcgaggcc cctaattata gcggccggtt cacctgttcc 1560 tggctggtgc agagaaacat ggacctgaag tttaatatca agagctcctc tagctcccca 1620 gatagccggg cagtgacatg cggaatggcc agcctgtccg ccgagaaggt gaccctggac 1680 cagagagatt acgagaagta ttctgtgagc tgccaggagg acgtgacatg tcccaccgcc 1740 gaggagacac tgcctatcga gctggccctg gaggccaggc agcagaacaa gtacgagaat 1800 tattccacct ctttctttat ccgcgacatc atcaagccag atccccctaa gaacctgcag 1860 atgaagcccc tgaagaattc ccaggtcgag gtgtcttggg agtaccctga cagctggtcc 1920 acaccacact cttatttcag cctgaagttc tttgtgagga tccagcgcaa gaaggagaag 1980 atgaaggaga ccgaggaggg ctgcaatcag aagggcgcct ttctggtgga gaagacatcc 2040 accgaggtgc agtgcaaggg aggaaacgtg tgcgtgcagg cacaggatcg gtactataat 2100 tctagctgtt ccaagtgggc ctgcgtgcct tgtcgggtga gatctggcac agccgaggcc 2160 gctagcgcca gcggcgaggc cggccggagc gccaaccaca cccccgccgg cctgaccggc 2220 cctggtacct cagagtctgc tacccccgag tcagggccag gatcagagcc agccacctcc 2280 gggtctgaga cacccgggac ttccgagagt gccacccctg agtccggacc cgggtccgag 2340 cccgccactt ccggctccga aactcccggc acaagcgaga gcgctacccc agagtcagga 2400 ccaggaacat ctacagagcc ctctgaaggc tccgctccag ggtccccagc cggcagtccc 2460 actagcaccg aggagggaac ctctgaaagc gccacacccg aatcagggcc agggtctgag 2520 cctgctacca gcggcagcga gacaccaggc acctctgagt ccgccacacc agagtccgga 2580 cccggatctc ccgctgggag ccccacctcc actgaggagg gatctcctgc tggctctcca 2640 acatctactg aggaaggtac ctcaaccgag ccatccgagg gatcagctcc cggcacctca 2700 gagtcggcaa ccccggagtc tggacccgga acttccgaaa gtgccacacc agagtccggt 2760 cccgggactt cagaatcagc aacacccgag tccggccctg ggtctgaacc cgccacaagt 2820 ggtagtgaga caccaggatc agaacctgct acctcagggt cagagacacc cggatctccg 2880 gcaggctcac caacctccac tgaggagggc accagcacag aaccaagcga gggctccgca 2940 cccggaacaa gcactgaacc cagtgagggt tcagcacccg gctctgagcc ggccacaagt 3000 ggcagtgaga cacccggcac ttcagagagt gccacccccg agagtggccc aggcactagt 3060 accgagccct ctgaaggcag tgcgcca 3087 <![CDATA[<210> 835]]> <![CDATA[<211> 2823]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 835]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcatgtggga gctggagaag 960 gacgtgtacg tggtggaggt ggactggaca ccagatgccc ccggcgagac cgtgaacctg 1020 acatgcgaca cccccgagga ggacgatatc acctggacat ctgatcagag gcacggcgtg 1080 atcggaagcg gcaagaccct gacaatcacc gtgaaggagt tcctggatgc cggccagtac 1140 acatgtcaca agggcggcga gaccctgtcc cactctcacc tgctgctgca caagaaggag 1200 aacggcatct ggtccacaga gatcctgaag aacttcaaga ataagacctt tctgaagtgc 1260 gaggccccta attatagcgg ccggttcacc tgttcctggc tggtgcagag aaacatggac 1320 ctgaagttta atatcaagag ctcctctagc tccccagata gccgggcagt gacatgcgga 1380 atggccagcc tgtccgccga gaaggtgacc ctggaccaga gagattacga gaagtattct 1440 gtgagctgcc aggaggacgt gacatgtccc accgccgagg agacactgcc tatcgagctg 1500 gccctggagg ccaggcagca gaacaagtac gagaattatt ccacctcttt ctttatccgc 1560 gacatcatca agccagatcc ccctaagaac ctgcagatga agcccctgaa gaattcccag 1620 gtcgaggtgt cttgggagta ccctgacagc tggtccacac cacactctta tttcagcctg 1680 aagttctttg tgaggatcca gcgcaagaag gagaagatga aggagaccga ggagggctgc 1740 aatcagaagg gcgcctttct ggtggagaag acatccaccg aggtgcagtg caagggagga 1800 aacgtgtgcg tgcaggcaca ggatcggtac tataattcta gctgttccaa gtgggcctgc 1860 gtgccttgtc gggtgagatc tggcacagcc gaggccgcta gcgccagcgg cgaggccggc 1920 cggagcgcca accacacccc cgccggcctg accggccctg gtacctcaga gtctgctacc 1980 cccgagtcag ggccaggatc agagccagcc acctccgggt ctgagacacc cgggacttcc 2040 gagagtgcca cccctgagtc cggacccggg tccgagcccg ccacttccgg ctccgaaact 2100 cccggcacaa gcgagagcgc taccccagag tcaggaccag gaacatctac agagccctct 2160 gaaggctccg ctccagggtc cccagccggc agtcccacta gcaccgagga gggaacctct 2220 gaaagcgcca cacccgaatc agggccaggg tctgagcctg ctaccagcgg cagcgagaca 2280 ccaggcacct ctgagtccgc cacaccagag tccggacccg gatctcccgc tgggagcccc 2340 acctccactg aggagggatc tcctgctggc tctccaacat ctactgagga aggtacctca 2400 accgagccat ccgagggatc agctcccggc acctcagagt cggcaacccc ggagtctgga 2460 cccggaactt ccgaaagtgc cacaccagag tccggtcccg ggacttcaga atcagcaaca 2520 cccgagtccg gccctgggtc tgaacccgcc acaagtggta gtgagacacc aggatcagaa 2580 cctgctacct cagggtcaga gacacccgga tctccggcag gctcaccaac ctccactgag 2640 gagggcacca gcacagaacc aagcgagggc tccgcacccg gaacaagcac tgaacccagt 2700 gagggttcag cacccggctc tgagccggcc acaagtggca gtgagacacc cggcacttca 2760 gagagtgcca cccccgagag tggcccaggc actagtaccg agccctctga aggcagtgcg 2820 cca 2823 <![CDATA[<210> 836]]> <![CDATA[<211> 3687]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 836]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccaggttct cctgctggct cccccacctc aacagaagag 900 gggacaagcg aaagcgctac gcctgagagt ggccctggct ctgagccagc cacctccggc 960 tctgaaaccc ctggcactag tgagtctgcc acgcctgagt ccggacccgg gacctctact 1020 gagccctcgg aggggagcgc tcctggcacg agtacagaac cttccgaagg aagtgcaccg 1080 ggcacaagca ccgagccttc cgaaggctct gctcccggaa cctctaccga accctctgaa 1140 gggtctgcac ccggcacgag caccgaaccc agcgaagggt cagcgcctgg gacctcaaca 1200 gagccctcgg aaggatcagc gcctggaagc cctgcaggga gtccaacttc cacggaagaa 1260 ggaacgtcta cagagccatc agaggggtcc gcaccagagg ccggccggag cgccaaccac 1320 acccccgccg gcctgaccgg ccctggcaca gccgaggccg ctagcgccag cggcatgtgg 1380 gagctggaga aggacgtgta cgtggtggag gtggactgga caccagatgc ccccggcgag 1440 accgtgaacc tgacatgcga cacccccgag gaggacgata tcacctggac atctgatcag 1500 aggcacggcg tgatcggaag cggcaagacc ctgacaatca ccgtgaagga gttcctggat 1560 gccggccagt acacatgtca caagggcggc gagaccctgt cccactctca cctgctgctg 1620 cacaagaagg agaacggcat ctggtccaca gagatcctga agaacttcaa gaataagacc 1680 tttctgaagt gcgaggcccc taattatagc ggccggttca cctgttcctg gctggtgcag 1740 agaaacatgg acctgaagtt taatatcaag agctcctcta gctccccaga tagccgggca 1800 gtgacatgcg gaatggccag cctgtccgcc gagaaggtga ccctggacca gagagattac 1860 gagaagtatt ctgtgagctg ccaggaggac gtgacatgtc ccaccgccga ggagacactg 1920 cctatcgagc tggccctgga ggccaggcag cagaacaagt acgagaatta ttccacctct 1980 ttctttatcc gcgacatcat caagccagat ccccctaaga acctgcagat gaagcccctg 2040 aagaattccc aggtcgaggt gtcttgggag taccctgaca gctggtccac accacactct 2100 tatttcagcc tgaagttctt tgtgaggatc cagcgcaaga aggagaagat gaaggagacc 2160 gaggagggct gcaatcagaa gggcgccttt ctggtggaga agacatccac cgaggtgcag 2220 tgcaagggag gaaacgtgtg cgtgcaggca caggatcggt actataattc tagctgttcc 2280 aagtgggcct gcgtgccttg tcgggtgaga tctggcacag ccgaggccgc tagcgccagc 2340 ggcgaggccg gccggagcgc caaccacacc cccgccggcc tgaccggccc tggtaccagc 2400 gaatccgcta ctcccgaatc tggccctggg tccgaacctg ccacctccgg ctctgaaact 2460 ccagggacct ccgaatctgc cacacccgag agcggccctg gctccgagcc cgcaacatct 2520 ggcagcgaga cacctggcac ctccgagagc gcaacacccg agagcggccc tggcaccagc 2580 accgagccat ccgagggatc cgccccaggc acttctgagt cagccacacc cgaaagcgga 2640 ccaggatcac ccgctggctc ccccaccagt accgaggagg ggtcccccgc tggaagtcca 2700 acaagcactg aggaagggtc ccctgccggc tcccccacaa gtaccgaaga gggcacaagt 2760 gagagcgcca ctcccgagtc cgggcctggc accagcacag agccttccga ggggtccgca 2820 ccaggtacct cagagtctgc tacccccgag tcagggccag gatcagagcc agccacctcc 2880 gggtctgaga cacccgggac ttccgagagt gccacccctg agtccggacc cgggtccgag 2940 cccgccactt ccggctccga aactcccggc acaagcgaga gcgctacccc agagtcagga 3000 ccaggaacat ctacagagcc ctctgaaggc tccgctccag ggtccccagc cggcagtccc 3060 actagcaccg aggagggaac ctctgaaagc gccacacccg aatcagggcc agggtctgag 3120 cctgctacca gcggcagcga gacaccaggc acctctgagt ccgccacacc agagtccgga 3180 cccggatctc ccgctgggag ccccacctcc actgaggagg gatctcctgc tggctctcca 3240 acatctactg aggaaggtac ctcaaccgag ccatccgagg gatcagctcc cggcacctca 3300 gagtcggcaa ccccggagtc tggacccgga acttccgaaa gtgccacacc agagtccggt 3360 cccgggactt cagaatcagc aacacccgag tccggccctg ggtctgaacc cgccacaagt 3420 ggtagtgaga caccaggatc agaacctgct acctcagggt cagagacacc cggatctccg 3480 gcaggctcac caacctccac tgaggagggc accagcacag aaccaagcga gggctccgca 3540 cccggaacaa gcactgaacc cagtgagggt tcagcacccg gctctgagcc ggccacaagt 3600 ggcagtgaga cacccggcac ttcagagagt gccacccccg agagtggccc aggcactagt 3660 accgagccct ctgaaggcag tgcgcca 3687 <![CDATA[<210> 837]]> <![CDATA[<211> 3003]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 837]]> gcaagctccg ccacccccga gtctggacca ggcaccagca cagagccttc tgagggaagc 60 gccccaggca caagcgagtc cgccacccct gagtccggac caggatctgg accagccacc 120 tctgagagcg ccacacctgg cacctccgag tctgccacac ctgagagcgg accaggatcc 180 gagccagcca ccagcggctc cgagacacca ggcacctctg aaagcgccac tcctgagtcc 240 ggaccaggca cctctacaga gccttccgag ggatctgccc caggaagccc agcaggcagc 300 ccaacctcca cagaggaggg cacatccgag tctgccactc ctgagtctgg acctggaagc 360 gagccagcca caagcggaag cgaaacacca ggcacctctg agagcgccac gcctgagtcc 420 ggacctggat ctccagccgg ctctcctacc agcacagagg agggatcccc agcaggatcc 480 cctacctcta cagaggaggg caccagcaca gagccaagcg agggatccgc ccctggcaca 540 tccgaatctg ccaccccaga gtccggacct ggcacaagcg aatccgccac ccctgagagc 600 ggaccaggca catctgagag cgccacccca gagagcggac ctggatccga gccagccaca 660 tccggatctg agaccccagg atccgagcct gccacaagcg gatccgagac cccaggaagc 720 cctgcaggat ctcccaccag caccgaagaa ggcaccagca ccgagcccag cgaaggatct 780 gcccctggca ccagcaccga gcctagcgag ggatccgccc ccggctccga gccagccacc 840 tctggaagtg aaacaccagg cacctccgaa tctgccacac cagaggcagg ccggtccgcc 900 aaccacaccc cagcaggact gacaggacca ggcaccagcg aatccgccac tccagagagc 960 atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg actggacacc agatgccccc 1020 ggcgagaccg tgaatctgac atgcgacacc cccgaggagg acgatatcac ctggacatcc 1080 gatcagagac acggcgtgat cggctctggc aagaccctga caatcaccgt gaaggagttc 1140 ctggatgccg gccagtacac atgtcacaag ggcggcgaga ccctgtctca cagccacctg 1200 ctgctgcaca agaaggagaa cggcatctgg tccacagaga tcctgaagaa cttcaagaat 1260 aagacctttc tgaagtgcga ggccccaaat tatagcggcc ggttcacctg ttcctggctg 1320 gtgcagagaa acatggacct gaagtttaat atcaagtcta gctcctctag cccagatagc 1380 agggcagtga catgcggaat ggcatccctg tctgccgaga aggtgaccct ggaccagaga 1440 gattacgaga agtatagcgt gtcctgccag gaggacgtga catgtcctac cgccgaggag 1500 accctgccaa tcgagctggc cctggaggcc aggcagcaga acaagtacga gaattattct 1560 accagcttct ttatccgcga catcatcaag ccagatcccc ctaagaacct gcagatgaag 1620 cccctgaaga atagccaggt cgaggtgtcc tgggagtacc ctgactcctg gtctacccca 1680 cactcttatt tcagcctgaa gttctttgtg aggatccagc gcaagaagga gaagatgaag 1740 gagaccgagg agggctgcaa ccagaagggc gcctttctgg tggagaagac atccaccgag 1800 gtgcagtgca agggaggaaa cgtgtgcgtg caggcacagg ataggtacta taattcctct 1860 tgtagcaagt gggcctgcgt gccctgtcgg gtgagatctg gcacagctac tccagaaagc 1920 ggaccaggag aggcaggccg cagcgccaat catactcctg ccggactgac aggacctgca 1980 actcctgagt ctggacccgg cagccctgca ggatccccca catctaccga agaaggatcc 2040 ccagcaggaa gccctacatc caccgaggag ggaagcccag caggatctcc cacaagcacc 2100 gaggagggca caagcgagtc cgccacgcct gagtctggac caggcacaag caccgagcca 2160 tccgagggat ctgcccctgg cacatctgaa agcgccactc ccgaaagcgg acctggatct 2220 gagccagcca cctccggatc tgagacacca ggcaccagcg agtccgccac acccgaatcc 2280 ggcccaggca gcgaacctgc cacctctgga agcgagaccc caggcacctc cgagtctgcc 2340 acgcccgaat ccggacctgg cacatctacc gaaccttccg aaggatccgc ccctggcagc 2400 ccagcaggat ctcctacaag cactgaagag ggcacaagcg agtccgccac tccagagtct 2460 ggaccaggaa gcgagcctgc cacctctggc agcgagaccc ccggcacctc cgagtctgcc 2520 acccctgaat ctggccctgg atctccagcc gggtccccca catctaccga ggaaggctcc 2580 ccagcaggaa gccccacatc cactgaagaa ggcacaagca ctgaaccatc cgaaggcagc 2640 gcccctggca caagcgagtc cgccacacca gagtcaggcc ctggcacatc tgagagcgcc 2700 acgccagaga gcggacctgg cacatcccca tctgccactc ctgagagtgg ccccgggtct 2760 gaaccagcca caagcggcag cgaaactcct ggctccgagc ctgccacatc tgggtccgaa 2820 actcctggct ccccagccgg cagccccaca tctactgagg agggcacaag cactgaaccc 2880 tccgagggat ccgccccagg cacatctacc gagccctccg aaggaagcgc cccaggaagc 2940 gaacctgcca cctccggctc cgaaacccct ggcaccagcg aatccgccgg agagcctgag 3000 gcc 3003 <![CDATA[<210> 838]]> <![CDATA[<211> 2211]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 838]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgaggccggc 1560 cggagcgcca accacacccc cgccggcctg accggccctg gtacctcaga gtctgctacc 1620 cccgagtcag ggccaggatc agagccagcc acctccgggt ctgagacacc cgggacttcc 1680 gagagtgcca cccctgagtc cggacccggg tccgagcccg ccacttccgg ctccgaaact 1740 cccggcacaa gcgagagcgc taccccagag tcaggaccag gaacatctac agagccctct 1800 gaaggctccg ctccagggtc cccagccggc agtcccacta gcaccgagga gggaacctct 1860 gaaagcgcca cacccgaatc agggccaggg tctgagcctg ctaccagcgg cagcgagaca 1920 ccaggcacct ctgagtccgc cacaccagag tccggacccg gatctcccgc tgggagcccc 1980 acctccactg aggagggatc tcctgctggc tctccaacat ctactgagga aggtacctca 2040 accgagccat ccgagggatc agctcccggc acctcagagt cggcaacccc ggagtctgga 2100 cccggaactt ccgaaagtgc cacaccagag tccggtcccg ggacttcaga atcagcaaca 2160 cccgagtccg gccctgggtc tgaacccgcc acaagtggtg aacctgaggc c 2211 <![CDATA[<210> 839]]> <![CDATA[<211> 2739]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 839]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgaggccggc 1560 cggagcgcca accacacccc cgccggcctg accggccctg agagcggccc tggcaccagc 1620 accgagccat ccgagggatc cgccccaggc acttctgagt cagccacacc cgaaagcgga 1680 ccaggatcac ccgctggctc ccccaccagt accgaggagg ggtcccccgc tggaagtcca 1740 acaagcactg aggaagggtc ccctgccggc tcccccacaa gtaccgaaga gggcacaagt 1800 gagagcgcca ctcccgagtc cgggcctggc accagcacag agccttccga ggggtccgca 1860 ccaggtacct cagagtctgc tacccccgag tcagggccag gatcagagcc agccacctcc 1920 gggtctgaga cacccgggac ttccgagagt gccacccctg agtccggacc cgggtccgag 1980 cccgccactt ccggctccga aactcccggc acaagcgaga gcgctacccc agagtcagga 2040 ccaggaacat ctacagagcc ctctgaaggc tccgctccag ggtccccagc cggcagtccc 2100 actagcaccg aggagggaac ctctgaaagc gccacacccg aatcagggcc agggtctgag 2160 cctgctacca gcggcagcga gacaccaggc acctctgagt ccgccacacc agagtccgga 2220 cccggatctc ccgctgggag ccccacctcc actgaggagg gatctcctgc tggctctcca 2280 acatctactg aggaaggtac ctcaaccgag ccatccgagg gatcagctcc cggcacctca 2340 gagtcggcaa ccccggagtc tggacccgga acttccgaaa gtgccacacc agagtccggt 2400 cccgggactt cagaatcagc aacacccgag tccggccctg ggtctgaacc cgccacaagt 2460 ggtagtgaga caccaggatc agaacctgct acctcagggt cagagacacc cggatctccg 2520 gcaggctcac caacctccac tgaggagggc accagcacag aaccaagcga gggctccgca 2580 cccggaacaa gcactgaacc cagtgagggt tcagcacccg gctctgagcc ggccacaagt 2640 ggcagtgaga cacccggcac ttcagagagt gccacccccg agagtggccc aggcactagt 2700 accgagccct ctgaaggcag tgcgccagaa cctgaggcc 2739 <![CDATA[<210> 840]]> <![CDATA[<211> 2214]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 840]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgaggccggc 1560 cggagcgcca accacacccc cgccggcctg accggccctg gtacctcaga gtctgctacc 1620 cccgagtcag ggccaggatc agagccagcc acctccgggt ctgagacacc cgggacttcc 1680 gagagtgcca cccctgagtc cggacccggg tccgagcccg ccacttccgg ctccgaaact 1740 cccggcacaa gcgagagcgc taccccagag tcaggaccag gaacatctac agagccctct 1800 gaaggctccg ctccagggtc cccagccggc agtcccacta gcaccgagga gggaacctct 1860 gaaagcgcca cacccgaatc agggccaggg tctgagcctg ctaccagcgg cagcgagaca 1920 ccaggcacct ctgagtccgc cacaccagag tccggacccg gatctcccgc tgggagcccc 1980 acctccactg aggagggatc tcctgctggc tctccaacat ctactgagga aggtacctca 2040 accgagccat ccgagggatc agctcccggc acctcagagt cggcaacccc ggagtctgga 2100 cccggaactt ccgaaagtgc cacaccagag tccggtcccg ggacttcaga atcagcaaca 2160 cccgagtccg gccctgggtc tgaacccgcc acaagtggtg aacctgaggc ctaa 2214 <![CDATA[<210> 841]]> <![CDATA[<211> 1524]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 841]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc ctaa 1524 <![CDATA[<210> 842]]> <![CDATA[<211> 2508]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 842]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgtgctgcag 1560 agcccaggca cagccgaggc cgctagcgcc agcggcgagg ccggccggag cgccaaccac 1620 acccccgccg gcctgaccgg ccctggtacc tcagagtctg ctacccccga gtcagggcca 1680 ggatcagagc cagccacctc cgggtctgag acacccggga cttccgagag tgccacccct 1740 gagtccggac ccgggtccga gcccgccact tccggctccg aaactcccgg cacaagcgag 1800 agcgctaccc cagagtcagg accaggaaca tctacagagc cctctgaagg ctccgctcca 1860 gggtccccag ccggcagtcc cactagcacc gaggagggaa cctctgaaag cgccacaccc 1920 gaatcagggc cagggtctga gcctgctacc agcggcagcg agacaccagg cacctctgag 1980 tccgccacac cagagtccgg acccggatct cccgctggga gccccacctc cactgaggag 2040 ggatctcctg ctggctctcc aacatctact gaggaaggta cctcaaccga gccatccgag 2100 ggatcagctc ccggcacctc agagtcggca accccggagt ctggacccgg aacttccgaa 2160 agtgccacac cagagtccgg tcccgggact tcagaatcag caacacccga gtccggccct 2220 gggtctgaac ccgccacaag tggtagtgag acaccaggat cagaacctgc tacctcaggg 2280 tcagagacac ccggatctcc ggcaggctca ccaacctcca ctgaggaggg caccagcaca 2340 gaaccaagcg agggctccgc acccggaaca agcactgaac ccagtgaggg ttcagcaccc 2400 ggctctgagc cggccacaag tggcagtgag acacccggca cttcagagag tgccaccccc 2460 gagagtggcc caggcactag taccgagccc tctgaaggca gtgcgcca 2508 <![CDATA[<210> 843]]> <![CDATA[<211> 2463]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 843]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccagaggcc ggccggagcg ccaaccacac ccccgccggc 900 ctgaccggcc ctggcacagc cgaggccgct agcgccagcg gcagagtgat ccccgtgagc 960 ggaccagcaa ggtgcctgtc ccagagccgg aacctgctga agaccacaga cgatatggtg 1020 aagaccgccc gggagaagct gaagcactac tcttgtacag ccgaggacat cgatcacgag 1080 gacatcaccc gggatcagac ctctacactg aagacatgcc tgcccctgga gctgcacaag 1140 aacgagagct gtctggccac ccgggagaca agctccacca caagaggcag ctgcctgccc 1200 cctcagaaga cctccctgat gatgaccctg tgcctgggct ctatctacga ggacctgaag 1260 atgtatcaga ccgagttcca ggccatcaat gccgccctgc agaaccacaa tcaccagcag 1320 atcatcctgg acaagggcat gctggtggcc atcgatgagc tgatgcagag cctgaaccac 1380 aatggcgaga ccctgaggca gaagccacca gtgggagagg cagatcctta cagggtgaag 1440 atgaagctgt gcatcctgct gcacgccttt tccaccaggg tggtgacaat caatcgcgtg 1500 atgggctatc tgtctagcgc cggcacagcc gaggccgcta gcgccagcgg cgaggccggc 1560 cggagcgcca accacacccc cgccggcctg accggccctg gtacctcaga gtctgctacc 1620 cccgagtcag ggccaggatc agagccagcc acctccgggt ctgagacacc cgggacttcc 1680 gagagtgcca cccctgagtc cggacccggg tccgagcccg ccacttccgg ctccgaaact 1740 cccggcacaa gcgagagcgc taccccagag tcaggaccag gaacatctac agagccctct 1800 gaaggctccg ctccagggtc cccagccggc agtcccacta gcaccgagga gggaacctct 1860 gaaagcgcca cacccgaatc agggccaggg tctgagcctg ctaccagcgg cagcgagaca 1920 ccaggcacct ctgagtccgc cacaccagag tccggacccg gatctcccgc tgggagcccc 1980 acctccactg aggagggatc tcctgctggc tctccaacat ctactgagga aggtacctca 2040 accgagccat ccgagggatc agctcccggc acctcagagt cggcaacccc ggagtctgga 2100 cccggaactt ccgaaagtgc cacaccagag tccggtcccg ggacttcaga atcagcaaca 2160 cccgagtccg gccctgggtc tgaacccgcc acaagtggta gtgagacacc aggatcagaa 2220 cctgctacct cagggtcaga gacacccgga tctccggcag gctcaccaac ctccactgag 2280 gagggcacca gcacagaacc aagcgagggc tccgcacccg gaacaagcac tgaacccagt 2340 gagggttcag cacccggctc tgagccggcc acaagtggca gtgagacacc cggcacttca 2400 gagagtgcca cccccgagag tggcccaggc actagtaccg agccctctga aggcagtgcg 2460 cca 2463 <![CDATA[<210> 844]]> <![CDATA[<211> 3327]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 844]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccaggttct cctgctggct cccccacctc aacagaagag 900 gggacaagcg aaagcgctac gcctgagagt ggccctggct ctgagccagc cacctccggc 960 tctgaaaccc ctggcactag tgagtctgcc acgcctgagt ccggacccgg gacctctact 1020 gagccctcgg aggggagcgc tcctggcacg agtacagaac cttccgaagg aagtgcaccg 1080 ggcacaagca ccgagccttc cgaaggctct gctcccggaa cctctaccga accctctgaa 1140 gggtctgcac ccggcacgag caccgaaccc agcgaagggt cagcgcctgg gacctcaaca 1200 gagccctcgg aaggatcagc gcctggaagc cctgcaggga gtccaacttc cacggaagaa 1260 ggaacgtcta cagagccatc agaggggtcc gcaccagagg ccggccggag cgccaaccac 1320 acccccgccg gcctgaccgg ccctggcaca gccgaggccg ctagcgccag cggcagagtg 1380 atccccgtga gcggaccagc aaggtgcctg tcccagagcc ggaacctgct gaagaccaca 1440 gacgatatgg tgaagaccgc ccgggagaag ctgaagcact actcttgtac agccgaggac 1500 atcgatcacg aggacatcac ccgggatcag acctctacac tgaagacatg cctgcccctg 1560 gagctgcaca agaacgagag ctgtctggcc acccgggaga caagctccac cacaagaggc 1620 agctgcctgc cccctcagaa gacctccctg atgatgaccc tgtgcctggg ctctatctac 1680 gaggacctga agatgtatca gaccgagttc caggccatca atgccgccct gcagaaccac 1740 aatcaccagc agatcatcct ggacaagggc atgctggtgg ccatcgatga gctgatgcag 1800 agcctgaacc acaatggcga gaccctgagg cagaagccac cagtgggaga ggcagatcct 1860 tacagggtga agatgaagct gtgcatcctg ctgcacgcct tttccaccag ggtggtgaca 1920 atcaatcgcg tgatgggcta tctgtctagc gccggcacag ccgaggccgc tagcgccagc 1980 ggcgaggccg gccggagcgc caaccacacc cccgccggcc tgaccggccc tggtaccagc 2040 gaatccgcta ctcccgaatc tggccctggg tccgaacctg ccacctccgg ctctgaaact 2100 ccagggacct ccgaatctgc cacacccgag agcggccctg gctccgagcc cgcaacatct 2160 ggcagcgaga cacctggcac ctccgagagc gcaacacccg agagcggccc tggcaccagc 2220 accgagccat ccgagggatc cgccccaggc acttctgagt cagccacacc cgaaagcgga 2280 ccaggatcac ccgctggctc ccccaccagt accgaggagg ggtcccccgc tggaagtcca 2340 acaagcactg aggaagggtc ccctgccggc tcccccacaa gtaccgaaga gggcacaagt 2400 gagagcgcca ctcccgagtc cgggcctggc accagcacag agccttccga ggggtccgca 2460 ccaggtacct cagagtctgc tacccccgag tcagggccag gatcagagcc agccacctcc 2520 gggtctgaga cacccgggac ttccgagagt gccacccctg agtccggacc cgggtccgag 2580 cccgccactt ccggctccga aactcccggc acaagcgaga gcgctacccc agagtcagga 2640 ccaggaacat ctacagagcc ctctgaaggc tccgctccag ggtccccagc cggcagtccc 2700 actagcaccg aggagggaac ctctgaaagc gccacacccg aatcagggcc agggtctgag 2760 cctgctacca gcggcagcga gacaccaggc acctctgagt ccgccacacc agagtccgga 2820 cccggatctc ccgctgggag ccccacctcc actgaggagg gatctcctgc tggctctcca 2880 acatctactg aggaaggtac ctcaaccgag ccatccgagg gatcagctcc cggcacctca 2940 gagtcggcaa ccccggagtc tggacccgga acttccgaaa gtgccacacc agagtccggt 3000 cccgggactt cagaatcagc aacacccgag tccggccctg ggtctgaacc cgccacaagt 3060 ggtagtgaga caccaggatc agaacctgct acctcagggt cagagacacc cggatctccg 3120 gcaggctcac caacctccac tgaggagggc accagcacag aaccaagcga gggctccgca 3180 cccggaacaa gcactgaacc cagtgagggt tcagcacccg gctctgagcc ggccacaagt 3240 ggcagtgaga cacccggcac ttcagagagt gccacccccg agagtggccc aggcactagt 3300 accgagccct ctgaaggcag tgcgcca 3327 <![CDATA[<210> 845]]> <![CDATA[<211> 2163]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 845]]> gcaagctccg ccacccctga gtctggacca ggcaccagca cagagccttc cgagggatct 60 gccccaggca ccagcgagtc cgccacacca gagtccggac ctggatctgg accaggcacc 120 tctgagagcg ccaccccagg cacatccgag tctgccaccc cagagagcgg acctggatcc 180 gagccagcca caagcggatc cgagacccca ggcacatctg aaagcgccac tccagagtcc 240 ggacctggca cctctacaga gcctagcgag ggatccgccc ctggaagccc agccggctct 300 cctaccagca cagaggaggg cacctccgag tctgccacac cagagtctgg accaggaagc 360 gagcctgcca ccagcggcag cgaaactcca ggcacatctg agagcgccac ccctgagtcc 420 ggaccaggat ctcctgcagg atcccctacc tctacagagg agggaagccc agcaggaagc 480 cccacctcca ccgaagaggg cacctccaca gagccatctg agggaagcgc ccctggcacc 540 tccgaatctg ccacacctga gtccggaccc ggcaccagcg aatccgccac ccccgagtct 600 ggacctggca cctctgaaag cgccacacca gagagcggac caggatccga gcctgccacc 660 tccggatctg agacaccagg aagcgagcca gccaccagcg gatccgagac accaggctcc 720 cccgccggct cccccacctc tacagaggag ggcaccagca ccgaaccttc cgagggatcc 780 gcccccggca ccagcaccga gccttccgaa ggaagcgccc caggctccga gccagccacc 840 tctggaagtg aaactcctgg cacatccgaa tctgccaccc cagaggcagg caggtccgcc 900 aaccacacac cagcaggact gaccggacca ggcacaagcg agtccgccac cccagagagc 960 cgcgtgatcc ccgtgtccgg acctgcaagg tgcctgtctc agagcagaaa tctgctgaag 1020 accacagacg atatggtgaa gaccgcccgg gagaagctga agcactacag ctgtacagcc 1080 gaggacatcg atcacgagga catcaccaga gatcagacca gcacactgaa gacatgcctg 1140 cccctggagc tgcacaagaa cgagtcctgt ctggccaccc gggagacatc tagcaccaca 1200 agaggctctt gcctgccccc tcagaagacc agcctgatga tgaccctgtg cctgggcagc 1260 atctacgagg acctgaagat gtatcagacc gagttccagg ccatcaatgc cgccctgcag 1320 aaccacaatc accagcagat catcctggac aagggcatgc tggtggccat cgatgagctg 1380 atgcagagcc tgaaccacaa tggcgagacc ctgaggcaga agccaccagt gggagaggca 1440 gatccatacc gcgtgaagat gaagctgtgc atcctgctgc acgccttttc caccagggtg 1500 gtgacaatca accgcgtgat gggctatctg tcctctgccg gcactgctac accagagtcc 1560 ggaccaggag aggcaggccg gtctgccaat cacacccctg ccggactgac cggacctgca 1620 acaccagagt ctggacctgg ctctgagcca gccacctccg gctccgagac ccctggcaca 1680 agcgaatccg ccaccccaga aagcggccct ggctccccag ccggcagccc tacctctacc 1740 gaagaaggca gcccagcagg aagccctacc tccaccgagg aaggcacctc cacagagcct 1800 tctgagggaa gcgcccccgg cacctctgaa agcgccacgc cagaatccgg accaggcacc 1860 tccgagtctg ccacgcctga gtccggacca ggcaccagcg cctccgccac acccgagagc 1920 ggcccaggga gcgaaccagc cacctctgga agcgaaaccc ctggcagtga accagccacc 1980 tccggctctg agacaccagg atccccagcc ggctcaccta cctctaccga ggagggcacc 2040 agcactgaac ctagtgaggg atccgcccca ggcacctcta ccgaacctag cgaaggcagc 2100 gcccctggct cagagccagc caccagcggc agcgagactc ctggcacatc tgaaagcgcc 2160 ggc 2163 <![CDATA[<210> 846]]> <![CDATA[<211> 4233]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 846]]> atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg actggacacc agatgccccc 60 ggcgagaccg tgaacctgac atgcgacacc cccgaggagg acgatatcac ctggacatct 120 gatcagaggc acggcgtgat cggaagcggc aagaccctga caatcaccgt gaaggagttc 180 ctggatgccg gccagtacac atgtcacaag ggcggcgaga ccctgtccca ctctcacctg 240 ctgctgcaca agaaggagaa cggcatctgg tccacagaga tcctgaagaa cttcaagaat 300 aagacctttc tgaagtgcga ggcccctaat tatagcggcc ggttcacctg ttcctggctg 360 gtgcagagaa acatggacct gaagtttaat atcaagagct cctctagctc cccagatagc 420 cgggcagtga catgcggaat ggccagcctg tccgccgaga aggtgaccct ggaccagaga 480 gattacgaga agtattctgt gagctgccag gaggacgtga catgtcccac cgccgaggag 540 acactgccta tcgagctggc cctggaggcc aggcagcaga acaagtacga gaattattcc 600 acctctttct ttatccgcga catcatcaag ccagatcccc ctaagaacct gcagatgaag 660 cccctgaaga attcccaggt cgaggtgtct tgggagtacc ctgacagctg gtccacacca 720 cactcttatt tcagcctgaa gttctttgtg aggatccagc gcaagaagga gaagatgaag 780 gagaccgagg agggctgcaa tcagaagggc gcctttctgg tggagaagac atccaccgag 840 gtgcagtgca agggaggaaa cgtgtgcgtg caggcacagg atcggtacta taattctagc 900 tgttccaagt gggcctgcgt gccttgtcgg gtgagatctg gcggcggcgg ctctggcggc 960 ggcggctccg gcggcggcgg ctccagagtg atccccgtga gcggaccagc aaggtgcctg 1020 tcccagagcc ggaacctgct gaagaccaca gacgatatgg tgaagaccgc ccgggagaag 1080 ctgaagcact actcttgtac agccgaggac atcgatcacg aggacatcac ccgggatcag 1140 acctctacac tgaagacatg cctgcccctg gagctgcaca agaacgagag ctgtctggcc 1200 acccgggaga caagctccac cacaagaggc agctgcctgc cccctcagaa gacctccctg 1260 atgatgaccc tgtgcctggg ctctatctac gaggacctga agatgtatca gaccgagttc 1320 caggccatca atgccgccct gcagaaccac aatcaccagc agatcatcct ggacaagggc 1380 atgctggtgg ccatcgatga gctgatgcag agcctgaacc acaatggcga gaccctgagg 1440 cagaagccac cagtgggaga ggcagatcct tacagggtga agatgaagct gtgcatcctg 1500 ctgcacgcct tttccaccag ggtggtgaca atcaatcgcg tgatgggcta tctgtctagc 1560 gccggcacag ccgaggccgc tagcgccagc ggcgaggccg gccggagcgc caaccacacc 1620 cccgccggcc tgaccggccc tggttctcca gccgggtccc caacttcgac cgaggaaggg 1680 acctccgagt cagctacccc ggagtccggt cctggcacct ccaccgaacc atcggagggc 1740 agcgcccctg ggagccctgc cgggagccct acaagcaccg aagagggcac cagtacagag 1800 ccaagtgagg ggagcgcccc tggtactagt actgaaccat ccgaggggtc agctccaggc 1860 acgagtgagt ccgctacccc cgagagcgga ccgggctcag agcccgccac gagtggcagt 1920 gaaactccag gctcagaacc cgccactagt gggtcagaga ctccaggcag ccctgccgga 1980 tcccctacgt ccaccgagga gggaacatct gagtccgcaa cacccgaatc cggtccaggc 2040 acctccacgg aacctagtga aggctcggca ccaggtacaa gcaccgaacc tagcgagggc 2100 agcgctcccg gcagccctgc cggcagccca acctcaactg aggagggcac cagtactgag 2160 cccagcgagg gatcagcacc tggcaccagc accgaaccta gcgaggggag cgcccctggg 2220 actagcgagt cagctacacc agagagcggg cctggaactt ctaccgaacc cagtgaggga 2280 tccgctccag gcacctccga atccgcaacc cccgaatccg gacctggctc agagcccgcc 2340 accagcggga gcgaaacccc tggcacatcc accgagccta gcgaagggtc cgcacccggc 2400 accagtacag agcctagcga gggatcagca cctggcacca gtgaatctgc tacaccagag 2460 agcggccctg gaacctccga gtccgctacc cccgagagcg ggccaggttc tcctgctggc 2520 tcccccacct caacagaaga ggggacaagc gaaagcgcta cgcctgagag tggccctggc 2580 tctgagccag ccacctccgg ctctgaaacc cctggcacta gtgagtctgc cacgcctgag 2640 tccggacccg ggacctctac tgagccctcg gaggggagcg ctcctggcac gagtacagaa 2700 ccttccgaag gaagtgcacc gggcacaagc accgagcctt ccgaaggctc tgctcccgga 2760 acctctaccg aaccctctga agggtctgca cccggcacga gcaccgaacc cagcgaaggg 2820 tcagcgcctg ggacctcaac agagccctcg gaaggatcag cgcctggaag ccctgcaggg 2880 agtccaactt ccacggaaga aggaacgtct acagagccat cagaggggtc cgcaccaggt 2940 accagcgaat ccgctactcc cgaatctggc cctgggtccg aacctgccac ctccggctct 3000 gaaactccag ggacctccga atctgccaca cccgagagcg gccctggctc cgagcccgca 3060 acatctggca gcgagacacc tggcacctcc gagagcgcaa cacccgagag cggccctggc 3120 accagcaccg agccatccga gggatccgcc ccaggcactt ctgagtcagc cacacccgaa 3180 agcggaccag gatcacccgc tggctccccc accagtaccg aggaggggtc ccccgctgga 3240 agtccaacaa gcactgagga agggtcccct gccggctccc ccacaagtac cgaagagggc 3300 acaagtgaga gcgccactcc cgagtccggg cctggcacca gcacagagcc ttccgagggg 3360 tccgcaccag gtacctcaga gtctgctacc cccgagtcag ggccaggatc agagccagcc 3420 acctccgggt ctgagacacc cgggacttcc gagagtgcca cccctgagtc cggacccggg 3480 tccgagcccg ccacttccgg ctccgaaact cccggcacaa gcgagagcgc taccccagag 3540 tcaggaccag gaacatctac agagccctct gaaggctccg ctccagggtc cccagccggc 3600 agtcccacta gcaccgagga gggaacctct gaaagcgcca cacccgaatc agggccaggg 3660 tctgagcctg ctaccagcgg cagcgagaca ccaggcacct ctgagtccgc cacaccagag 3720 tccggacccg gatctcccgc tgggagcccc acctccactg aggagggatc tcctgctggc 3780 tctccaacat ctactgagga aggtacctca accgagccat ccgagggatc agctcccggc 3840 acctcagagt cggcaacccc ggagtctgga cccggaactt ccgaaagtgc cacaccagag 3900 tccggtcccg ggacttcaga atcagcaaca cccgagtccg gccctgggtc tgaacccgcc 3960 acaagtggta gtgagacacc aggatcagaa cctgctacct cagggtcaga gacacccgga 4020 tctccggcag gctcaccaac ctccactgag gagggcacca gcacagaacc aagcgagggc 4080 tccgcacccg gaacaagcac tgaacccagt gagggttcag cacccggctc tgagccggcc 4140 acaagtggca gtgagacacc cggcacttca gagagtgcca cccccgagag tggcccaggc 4200 actagtaccg agccctctga aggcagtgcg cca 4233 <![CDATA[<210> 847]]> <![CDATA[<211> 4233]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 847]]> ggttctccag ccgggtcccc aacttcgacc gaggaaggga cctccgagtc agctaccccg 60 gagtccggtc ctggcacctc caccgaacca tcggagggca gcgcccctgg gagccctgcc 120 gggagcccta caagcaccga agagggcacc agtacagagc caagtgaggg gagcgcccct 180 ggtactagta ctgaaccatc cgaggggtca gctccaggca cgagtgagtc cgctaccccc 240 gagagcggac cgggctcaga gcccgccacg agtggcagtg aaactccagg ctcagaaccc 300 gccactagtg ggtcagagac tccaggcagc cctgccggat cccctacgtc caccgaggag 360 ggaacatctg agtccgcaac acccgaatcc ggtccaggca cctccacgga acctagtgaa 420 ggctcggcac caggtacaag caccgaacct agcgagggca gcgctcccgg cagccctgcc 480 ggcagcccaa cctcaactga ggagggcacc agtactgagc ccagcgaggg atcagcacct 540 ggcaccagca ccgaacctag cgaggggagc gcccctggga ctagcgagtc agctacacca 600 gagagcgggc ctggaacttc taccgaaccc agtgagggat ccgctccagg cacctccgaa 660 tccgcaaccc ccgaatccgg acctggctca gagcccgcca ccagcgggag cgaaacccct 720 ggcacatcca ccgagcctag cgaagggtcc gcacccggca ccagtacaga gcctagcgag 780 ggatcagcac ctggcaccag tgaatctgct acaccagaga gcggccctgg aacctccgag 840 tccgctaccc ccgagagcgg gccaggttct cctgctggct cccccacctc aacagaagag 900 gggacaagcg aaagcgctac gcctgagagt ggccctggct ctgagccagc cacctccggc 960 tctgaaaccc ctggcactag tgagtctgcc acgcctgagt ccggacccgg gacctctact 1020 gagccctcgg aggggagcgc tcctggcacg agtacagaac cttccgaagg aagtgcaccg 1080 ggcacaagca ccgagccttc cgaaggctct gctcccggaa cctctaccga accctctgaa 1140 gggtctgcac ccggcacgag caccgaaccc agcgaagggt cagcgcctgg gacctcaaca 1200 gagccctcgg aaggatcagc gcctggaagc cctgcaggga gtccaacttc cacggaagaa 1260 ggaacgtcta cagagccatc agaggggtcc gcaccaggta ccagcgaatc cgctactccc 1320 gaatctggcc ctgggtccga acctgccacc tccggctctg aaactccagg gacctccgaa 1380 tctgccacac ccgagagcgg ccctggctcc gagcccgcaa catctggcag cgagacacct 1440 ggcacctccg agagcgcaac acccgagagc ggccctggca ccagcaccga gccatccgag 1500 ggatccgccc caggcacttc tgagtcagcc acacccgaaa gcggaccagg atcacccgct 1560 ggctccccca ccagtaccga ggaggggtcc cccgctggaa gtccaacaag cactgaggaa 1620 gggtcccctg ccggctcccc cacaagtacc gaagagggca caagtgagag cgccactccc 1680 gagtccgggc ctggcaccag cacagagcct tccgaggggt ccgcaccagg tacctcagag 1740 tctgctaccc ccgagtcagg gccaggatca gagccagcca cctccgggtc tgagacaccc 1800 gggacttccg agagtgccac ccctgagtcc ggacccgggt ccgagcccgc cacttccggc 1860 tccgaaactc ccggcacaag cgagagcgct accccagagt caggaccagg aacatctaca 1920 gagccctctg aaggctccgc tccagggtcc ccagccggca gtcccactag caccgaggag 1980 ggaacctctg aaagcgccac acccgaatca gggccagggt ctgagcctgc taccagcggc 2040 agcgagacac caggcacctc tgagtccgcc acaccagagt ccggacccgg atctcccgct 2100 gggagcccca cctccactga ggagggatct cctgctggct ctccaacatc tactgaggaa 2160 ggtacctcaa ccgagccatc cgagggatca gctcccggca cctcagagtc ggcaaccccg 2220 gagtctggac ccggaacttc cgaaagtgcc acaccagagt ccggtcccgg gacttcagaa 2280 tcagcaacac ccgagtccgg ccctgggtct gaacccgcca caagtggtag tgagacacca 2340 ggatcagaac ctgctacctc agggtcagag acacccggat ctccggcagg ctcaccaacc 2400 tccactgagg agggcaccag cacagaacca agcgagggct ccgcacccgg aacaagcact 2460 gaacccagtg agggttcagc acccggctct gagccggcca caagtggcag tgagacaccc 2520 ggcacttcag agagtgccac ccccgagagt ggcccaggca ctagtaccga gccctctgaa 2580 ggcagtgcgc cagaggccgg ccggagcgcc aaccacaccc ccgccggcct gaccggccct 2640 ggcacagccg aggccgctag cgccagcggc atgtgggagc tggagaagga cgtgtacgtg 2700 gtggaggtgg actggacacc agatgccccc ggcgagaccg tgaacctgac atgcgacacc 2760 cccgaggagg acgatatcac ctggacatct gatcagaggc acggcgtgat cggaagcggc 2820 aagaccctga caatcaccgt gaaggagttc ctggatgccg gccagtacac atgtcacaag 2880 ggcggcgaga ccctgtccca ctctcacctg ctgctgcaca agaaggagaa cggcatctgg 2940 tccacagaga tcctgaagaa cttcaagaat aagacctttc tgaagtgcga ggcccctaat 3000 tatagcggcc ggttcacctg ttcctggctg gtgcagagaa acatggacct gaagtttaat 3060 atcaagagct cctctagctc cccagatagc cgggcagtga catgcggaat ggccagcctg 3120 tccgccgaga aggtgaccct ggaccagaga gattacgaga agtattctgt gagctgccag 3180 gaggacgtga catgtcccac cgccgaggag acactgccta tcgagctggc cctggaggcc 3240 aggcagcaga acaagtacga gaattattcc acctctttct ttatccgcga catcatcaag 3300 ccagatcccc ctaagaacct gcagatgaag cccctgaaga attcccaggt cgaggtgtct 3360 tgggagtacc ctgacagctg gtccacacca cactcttatt tcagcctgaa gttctttgtg 3420 aggatccagc gcaagaagga gaagatgaag gagaccgagg agggctgcaa tcagaagggc 3480 gcctttctgg tggagaagac atccaccgag gtgcagtgca agggaggaaa cgtgtgcgtg 3540 caggcacagg atcggtacta taattctagc tgttccaagt gggcctgcgt gccttgtcgg 3600 gtgagatctg gcggcggcgg ctctggcggc ggcggctccg gcggcggcgg ctccagagtg 3660 atccccgtga gcggaccagc aaggtgcctg tcccagagcc ggaacctgct gaagaccaca 3720 gacgatatgg tgaagaccgc ccgggagaag ctgaagcact actcttgtac agccgaggac 3780 atcgatcacg aggacatcac ccgggatcag acctctacac tgaagacatg cctgcccctg 3840 gagctgcaca agaacgagag ctgtctggcc acccgggaga caagctccac cacaagaggc 3900 agctgcctgc cccctcagaa gacctccctg atgatgaccc tgtgcctggg ctctatctac 3960 gaggacctga agatgtatca gaccgagttc caggccatca atgccgccct gcagaaccac 4020 aatcaccagc agatcatcct ggacaagggc atgctggtgg ccatcgatga gctgatgcag 4080 agcctgaacc acaatggcga gaccctgagg cagaagccac cagtgggaga ggcagatcct 4140 tacagggtga agatgaagct gtgcatcctg ctgcacgcct tttccaccag ggtggtgaca 4200 atcaatcgcg tgatgggcta tctgtctagc gcc 4233 <![CDATA[<210> 848]]> <![CDATA[<211> 5169]]> <![CDATA[<212> DNA]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 848]]> gcaagctccg ccaccccaga gtccggacct ggcacctcta cagagccaag cgagggatcc 60 gccccaggca caagcgagtc cgccacccca gagtctggac caggaagcgg acctgccacc 120 tctgagagcg ccacaccagg cacctccgag tctgccacac cagagtccgg accaggatct 180 gagcctgcca ccagcggatc cgagacacct ggcacctctg aaagcgccac tccagagagc 240 ggaccaggca cctccaccga gccttctgag ggaagcgccc caggaagccc tgcaggatcc 300 ccaacctcta cagaggaggg cacatccgag tctgccaccc ctgagagcgg accaggatcc 360 gagccagcca caagcggatc cgagacacca ggcacctctg agagcgccac gcctgaatcc 420 ggaccaggaa gcccagcagg aagccccacc tccacagagg agggatcccc tgcaggatct 480 ccaaccagca cagaggaggg caccagcaca gagccttccg agggctctgc cccaggcaca 540 tccgaatctg ccactcctga gtctggacct ggcacaagcg aatccgccac ccccgaaagc 600 ggaccaggca catctgagag cgccacccct gagtctggcc caggatctga gccagccaca 660 tccggctctg agacccctgg cagcgaacct gccacaagcg gcagcgagac ccctggaagc 720 ccagcaggct cccccacctc caccgaagaa ggcaccagca cagagccatc tgagggaagc 780 gcccctggca ccagcaccga accatccgag ggatctgccc caggatccga gcctgccacc 840 tctggcagtg aaacccctgg cacctccgaa tctgccacac ccgaggcagg ccggtccgcc 900 aaccacaccc cagccggcct gacaggacct ggcaccagcg aatccgccac tccagagagc 960 atgtgggagc tggagaagga cgtgtacgtg gtggaggtgg actggacacc cgatgcccct 1020 ggcgagaccg tgaatctgac atgcgacacc cctgaggagg acgatatcac ctggacatcc 1080 gatcagagac acggcgtgat cggctctggc aagaccctga caatcaccgt gaaggagttc 1140 ctggatgccg gccagtacac atgtcacaag ggcggcgaga ccctgtctca cagccacctg 1200 ctgctgcaca agaaggagaa cggcatctgg tccacagaga tcctgaagaa cttcaagaat 1260 aagacctttc tgaagtgcga ggcccccaat tatagcggca ggttcacctg ttcctggctg 1320 gtgcagcgca acatggacct gaagtttaat atcaagtcta gctcctctag ccctgatagc 1380 agggcagtga catgcggaat ggcatccctg tctgccgaga aggtgaccct ggaccagaga 1440 gattacgaga agtatagcgt gtcctgccag gaggacgtga catgtcctac cgccgaggag 1500 accctgccaa tcgagctggc cctggaggcc aggcagcaga acaagtacga gaattattct 1560 accagcttct ttatccgcga catcatcaag ccagatcccc ctaagaacct gcagatgaag 1620 cccctgaaga attcccaggt ggaggtgagc tgggagtacc cagactcctg gtctaccccc 1680 cacagctatt tctccctgaa gttctttgtg aggatccagc gcaagaagga gaagatgaag 1740 gagaccgagg agggctgcaa ccagaagggc gcctttctgg tggagaagac atccaccgag 1800 gtgcagtgca agggaggaaa cgtgtgcgtg caggcacagg ataggtacta taattcctct 1860 tgtagcaagt gggcatgcgt gccatgtcgg gtgagatccg gcacagctac tcctgaatct 1920 ggaccaggag aggcaggccg cagcgccaac cacacccctg caggactgac aggaccagca 1980 accccagaga gcggacctgg atccccagcc ggctctccaa caagcaccga agaaggatct 2040 ccagcaggat ccccaacatc taccgaggag ggctccccag caggaagccc tacatccacc 2100 gaggagggca caagcgagtc cgccacgcca gagtccggac caggcacatc taccgaacca 2160 agcgaaggaa gcgcccctgg cacatctgaa agcgccactc ccgaaagcgg accaggaagc 2220 gagccagcca cctccggatc tgagacacca ggcaccagcg agtccgccac acctgagtct 2280 gggcctggct ctgagccagc cacctctgga agtgaaaccc ccggcacctc cgagtctgcc 2340 acgcctgaga gcggaccagg cacatccacc gagcctagcg aaggctctgc ccctggcagc 2400 cctgccggct cccctacatc cactgaggag ggcacaagcg agtccgccac tcctgaaagc 2460 ggacctggat ccgaacctgc cacctctgga agtgagaccc ctggcacctc cgagtctgcc 2520 acccccgaat ctggccctgg ctccccagca ggctctccca caagcaccga ggagggatcc 2580 ccagcaggat cccctacatc tactgaagag ggcacaagca ccgaacctag cgagggatcc 2640 gcccctggca caagcgagtc cgccacaccc gaatctggcc ccggcacatc tgaaagcgcc 2700 acgccagaat ccggcccagg cacatcccca tctgccaccc ctgagtctgg gcctgggtct 2760 gaacctgcca caagcgggag cgagacccct ggcagcgagc cagccacatc tggatccgaa 2820 actccaggct ccccagcagg atcccccaca agcactgaag aaggcacaag caccgagcct 2880 agcgaggggt ctgcccctgg cacatctacc gagccctccg aaggctccgc cccaggaagc 2940 gagcctgcca cctccggctc tgagacacct ggcaccagcg agtccgccgg agcctcctcc 3000 gccactcctg aatccggacc tggcacaagc actgaacctt ccgaaggaag cgcccccggc 3060 acatctgaga gcgccactcc agaatccgga ccaggatccg gccccggcac ctccgagtct 3120 gccactcccg gcaccagcga atccgccacg cctgagtccg gccctgggag cgaacccgcc 3180 acctctggaa gcgaaacccc aggcacctcc gaatctgcca cgcctgagtc tggcccaggc 3240 acatctactg aacctagcga agggtctgcc cctgggagcc ctgcaggcag ccccacatcc 3300 acagaagaag gcacaagcga atccgccaca cctgagtccg gacctggatc cgagcccgcc 3360 acctctggct ccgaaactcc tggcacctcc gagtctgcca cgccggaatc tggaccagga 3420 tctcctgccg gatcccccac aagcacagaa gaagggagcc ctgccggatc ccctacatct 3480 acagaagagg gcacaagcac tgagccctcc gaagggtccg cccccggcac aagcgagtcc 3540 gccacgccgg aaagtggccc tggcacatct gagagcgcca cacccgagtc tgggccaggc 3600 acatccgagt ctgccacgcc agagtctgga cctggaagtg aacccgccac aagcggctcc 3660 gagactcctg gcagcgagcc tgccacatct ggatccgaga ctcctggaag cccagcagga 3720 tcacccacaa gcactgagga gggcacatcc accgagccca gcgagggatc tgcccctggc 3780 acatccacag aaccttccga aggatccgcc cctggctccg aacctgccac ctccgggagc 3840 gaaaccccag gcaccagcga atccgccacc ccagaggcag gccggagcgc caaccacacc 3900 cccgctggac tgaccggccc tggcacctct gagagcgcca ccccagagtc tagagtgatc 3960 cctgtgagcg gaccagcaag gtgcctgtcc cagtctagaa atctgctgaa gaccacagac 4020 gatatggtga agacagccag ggagaagctg aagcactaca gctgtaccgc cgaggacatc 4080 gatcacgagg acatcacacg cgatcagaca tccaccctga agacctgcct gcccctggag 4140 ctgcacaaga acgagagctg tctggccaca cgggagacct ctagcaccac aagaggcagc 4200 tgcctgccac cccagaagac atccctgatg atgaccctgt gcctgggcag catctacgag 4260 gacctgaaga tgtatcagac cgagttccag gccatcaatg ccgccctgca gaaccacaat 4320 caccagcaga tcatcctgga caagggcatg ctggtggcca tcgatgagct gatgcagtcc 4380 ctgaaccaca atggcgagac cctgaggcag aagcctccag tgggagaggc cgatccctac 4440 agagtgaaga tgaagctgtg catcctgctg cacgccttta gcacaagggt ggtgaccatc 4500 aaccgcgtga tgggctatct gtcctctgcc ggaacagcaa cccctgaatc tggacctgga 4560 gaggcaggca ggagcgccaa tcacacccca gccgggctga ccggcccagc aacccctgag 4620 tccggcccag ggtccgagcc agccaccagc ggcagcgaaa ctccaggcac ctctgagagc 4680 gccactcctg agtccgggcc aggatcccca gcaggatctc ctacaagcac tgaagaaggg 4740 tctcccgccg gcagcccaac atctactgag gaaggcacaa gcactgaacc ctccgaagga 4800 tccgcccccg gcacatccga gtctgccact cctgagagcg gacccggcac aagcgagtcc 4860 gccacgcctg aaagtggacc aggcacatct gccagcgcca ctccagaaag cggccctgga 4920 agcgaacctg ccacatccgg ctccgagacc cccggctctg aaccagccac aagcggcagc 4980 gaaactcccg gaagcccagc aggatctccc acaagcactg aagagggcac aagcacggag 5040 cctagcgaag gatctgcccc cggcacaagc actgaaccca gtgaaggatc cgccccaggc 5100 agcgaaccag ccacctctgg aagcgagacc cctggcacct ccgagtctgc cggagagcct 5160 gaggcctga 5169 <![CDATA[<210> 849]]> <![CDATA[<211> 1378]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 849]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 500 505 510 Ala Ser Ala Ser Gly Val Leu Gln Ser Pro Gly Thr Ser Glu Ser Ala 515 520 525 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 530 535 540 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 545 550 555 560 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 565 570 575 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 580 585 590 Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 660 665 670 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 675 680 685 Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 690 695 700 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 705 710 715 720 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 725 730 735 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 740 745 750 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 755 760 765 Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 785 790 795 800 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Glu Ile Val Leu Thr Gln 805 810 815 Ser Pro Gly Thr Leu Ser Leu Ser Pro Gly Glu Arg Ala Thr Leu Ser 820 825 830 Cys Arg Ala Ser Gln Ser Val Ser Ser Ser Phe Leu Ala Trp Tyr Gln 835 840 845 Gln Lys Pro Gly Gln Ala Pro Arg Leu Leu Ile Tyr Tyr Ala Ser Ser 850 855 860 Arg Ala Thr Gly Ile Pro Asp Arg Phe Ser Gly Ser Gly Ser Gly Thr 865 870 875 880 Asp Phe Thr Leu Thr Ile Ser Arg Leu Glu Pro Glu Asp Phe Ala Val 885 890 895 Tyr Tyr Cys Gln Gln Thr Gly Arg Ile Pro Pro Thr Phe Gly Gln Gly 900 905 910 Thr Lys Val Glu Ile Lys Gly Ala Thr Pro Pro Glu Thr Gly Ala Glu 915 920 925 Thr Glu Ser Pro Gly Glu Thr Thr Gly Gly Ser Ala Glu Ser Glu Pro 930 935 940 Pro Gly Glu Gly Glu Val Gln Leu Leu Glu Ser Gly Gly Gly Leu Val 945 950 955 960 Gln Pro Gly Gly Ser Leu Arg Leu Ser Cys Ala Ala Ser Gly Phe Thr 965 970 975 Phe Ser Ser Phe Ser Met Ser Trp Val Arg Gln Ala Pro Gly Lys Gly 980 985 990 Leu Glu Trp Val Ser Ser Ile Ser Gly Ser Ser Gly Thr Thr Tyr Tyr 995 1000 1005 Ala Asp Ser Val Lys Gly Arg Phe Thr Ile Ser Arg Asp Asn Ser 1010 1015 1020 Lys Asn Thr Leu Tyr Leu Gln Met Asn Ser Leu Arg Ala Glu Asp 1025 1030 1035 Thr Ala Val Tyr Tyr Cys Ala Lys Pro Phe Pro Tyr Phe Asp Tyr 1040 1045 1050 Trp Gly Gln Gly Thr Leu Val Thr Val Ser Ser Gly Thr Ala Glu 1055 1060 1065 Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr 1070 1075 1080 Pro Ala Gly Leu Thr Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 1085 1090 1095 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1100 1105 1110 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1115 1120 1125 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 1130 1135 1140 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 1145 1150 1155 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1160 1165 1170 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1175 1180 1185 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1190 1195 1200 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 1205 1210 1215 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1220 1225 1230 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 1235 1240 1245 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 1250 1255 1260 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 1265 1270 1275 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 1280 1285 1290 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 1295 1300 1305 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 1310 1315 1320 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 1325 1330 1335 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1340 1345 1350 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 1355 1360 1365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1370 1375 <![CDATA[<210> 850]]> <![CDATA[<211> 1203]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 850]]> Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 1 5 10 15 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 20 25 30 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 35 40 45 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 50 55 60 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 65 70 75 80 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 85 90 95 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 100 105 110 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 115 120 125 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 130 135 140 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 145 150 155 160 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 165 170 175 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 180 185 190 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 195 200 205 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 210 215 220 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 225 230 235 240 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 245 250 255 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 260 265 270 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 275 280 285 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 290 295 300 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Glu Ala Ala Ser 305 310 315 320 Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu 325 330 335 Thr Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 340 345 350 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 355 360 365 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 370 375 380 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 385 390 395 400 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 405 410 415 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 420 425 430 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 435 440 445 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 450 455 460 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 465 470 475 480 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 485 490 495 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 500 505 510 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 515 520 525 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 530 535 540 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 545 550 555 560 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 565 570 575 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 580 585 590 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 595 600 605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 610 615 620 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 625 630 635 640 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 645 650 655 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 660 665 670 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 675 680 685 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 690 695 700 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 705 710 715 720 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 725 730 735 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 740 745 750 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 755 760 765 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 770 775 780 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 785 790 795 800 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 805 810 815 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 820 825 830 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 835 840 845 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 850 855 860 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 865 870 875 880 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 885 890 895 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 900 905 910 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 915 920 925 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 930 935 940 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 945 950 955 960 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 965 970 975 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 980 985 990 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 995 1000 1005 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1010 1015 1020 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 1025 1030 1035 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 1040 1045 1050 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 1055 1060 1065 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1070 1075 1080 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1085 1090 1095 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 1100 1105 1110 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1115 1120 1125 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1130 1135 1140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1145 1150 1155 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr 1160 1165 1170 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1175 1180 1185 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1190 1195 1200 <![CDATA[<210> 851]]> <![CDATA[<211> 853]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 851]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ala Gly Arg Ser Ala Asn His 195 200 205 Thr Pro Ala Gly Leu Thr Gly Pro Gly Thr Ala Glu Ala Ala Ser Ala 210 215 220 Ser Gly Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp 225 230 235 240 Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr 245 250 255 Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val 260 265 270 Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp 275 280 285 Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser 290 295 300 His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile 305 310 315 320 Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn 325 330 335 Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp 340 345 350 Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala 355 360 365 Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp 370 375 380 Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr 385 390 395 400 Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala 405 410 415 Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg 420 425 430 Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu 435 440 445 Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser 450 455 460 Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg 465 470 475 480 Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly 485 490 495 Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly 500 505 510 Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser 515 520 525 Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Glu Ala 530 535 540 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 545 550 555 560 Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 565 570 575 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 580 585 590 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 595 600 605 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 610 615 620 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 625 630 635 640 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 645 650 655 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 660 665 670 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 675 680 685 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 705 710 715 720 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 740 745 750 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 755 760 765 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 770 775 780 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 785 790 795 800 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 805 810 815 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 820 825 830 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 835 840 845 Glu Gly Ser Ala Pro 850 <![CDATA[<210> 852]]> <![CDATA[<211> 1029]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 852]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Ala Gly Arg Ser Ala Asn His 370 375 380 Thr Pro Ala Gly Leu Thr Gly Pro Gly Thr Ala Glu Ala Ala Ser Ala 385 390 395 400 Ser Gly Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp 405 410 415 Trp Thr Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr 420 425 430 Pro Glu Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val 435 440 445 Ile Gly Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp 450 455 460 Ala Gly Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser 465 470 475 480 His Leu Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile 485 490 495 Leu Lys Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn 500 505 510 Tyr Ser Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp 515 520 525 Leu Lys Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala 530 535 540 Val Thr Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp 545 550 555 560 Gln Arg Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr 565 570 575 Cys Pro Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala 580 585 590 Arg Gln Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg 595 600 605 Asp Ile Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu 610 615 620 Lys Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser 625 630 635 640 Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg 645 650 655 Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly 660 665 670 Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly 675 680 685 Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser 690 695 700 Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Glu Ala 705 710 715 720 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 725 730 735 Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 740 745 750 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 755 760 765 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 770 775 780 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 785 790 795 800 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 805 810 815 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 820 825 830 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 835 840 845 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 850 855 860 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 865 870 875 880 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 885 890 895 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 900 905 910 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 915 920 925 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 930 935 940 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 945 950 955 960 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 965 970 975 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 980 985 990 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 995 1000 1005 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1010 1015 1020 Ser Glu Gly Ser Ala Pro 1025 <![CDATA[<210> 853]]> <![CDATA[<211> 941]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 853]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Met Trp Glu Leu Glu Lys 305 310 315 320 Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu 325 330 335 Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp 340 345 350 Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr 355 360 365 Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys 370 375 380 Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu 385 390 395 400 Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr 405 410 415 Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser 420 425 430 Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser 435 440 445 Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu 450 455 460 Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser 465 470 475 480 Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu 485 490 495 Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn 500 505 510 Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 515 520 525 Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser 530 535 540 Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 545 550 555 560 Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr 565 570 575 Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser 580 585 590 Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp 595 600 605 Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg 610 615 620 Val Arg Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly 625 630 635 640 Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro Gly Thr Ser 645 650 655 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 660 665 670 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 675 680 685 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 690 695 700 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 705 710 715 720 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 725 730 735 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 740 745 750 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 755 760 765 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 770 775 780 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 785 790 795 800 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 805 810 815 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 820 825 830 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 835 840 845 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser 850 855 860 Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 865 870 875 880 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 885 890 895 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 900 905 910 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 915 920 925 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 930 935 940 <![CDATA[<210> 854]]> <![CDATA[<211> 1229]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 854]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 435 440 445 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Met Trp Glu Leu Glu Lys 450 455 460 Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu 465 470 475 480 Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp 485 490 495 Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr 500 505 510 Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys 515 520 525 Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu 530 535 540 Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr 545 550 555 560 Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser 565 570 575 Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser Ser 580 585 590 Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala Ser Leu 595 600 605 Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu Lys Tyr Ser 610 615 620 Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala Glu Glu Thr Leu 625 630 635 640 Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln Asn Lys Tyr Glu Asn 645 650 655 Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile Ile Lys Pro Asp Pro Pro 660 665 670 Lys Asn Leu Gln Met Lys Pro Leu Lys Asn Ser Gln Val Glu Val Ser 675 680 685 Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro His Ser Tyr Phe Ser Leu 690 695 700 Lys Phe Phe Val Arg Ile Gln Arg Lys Lys Glu Lys Met Lys Glu Thr 705 710 715 720 Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe Leu Val Glu Lys Thr Ser 725 730 735 Thr Glu Val Gln Cys Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp 740 745 750 Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg 755 760 765 Val Arg Ser Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly 770 775 780 Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro Gly Thr Ser 785 790 795 800 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 805 810 815 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 820 825 830 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 835 840 845 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 850 855 860 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 865 870 875 880 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 885 890 895 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 900 905 910 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 915 920 925 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 930 935 940 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 945 950 955 960 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 965 970 975 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 980 985 990 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 995 1000 1005 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1010 1015 1020 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1025 1030 1035 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 1040 1045 1050 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 1055 1060 1065 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 1070 1075 1080 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 1085 1090 1095 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1100 1105 1110 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 1115 1120 1125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1130 1135 1140 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1145 1150 1155 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1160 1165 1170 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1175 1180 1185 Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1190 1195 1200 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1205 1210 1215 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1220 1225 <![CDATA[<210> 855]]> <![CDATA[<211> 1001]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 855]]> Ala Ser Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1 5 10 15 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 20 25 30 Gly Pro Gly Ser Gly Pro Ala Thr Ser Glu Ser Ala Thr Pro Gly Thr 35 40 45 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 50 55 60 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 65 70 75 80 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 85 90 95 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 100 105 110 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 115 120 125 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 130 135 140 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 145 150 155 160 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 165 170 175 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 180 185 190 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 195 200 205 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 210 215 220 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 225 230 235 240 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 245 250 255 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 260 265 270 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 275 280 285 Ser Glu Ser Ala Thr Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro 290 295 300 Ala Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 305 310 315 320 Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 325 330 335 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 340 345 350 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 355 360 365 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 370 375 380 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 385 390 395 400 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 405 410 415 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 420 425 430 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 435 440 445 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 450 455 460 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 465 470 475 480 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 485 490 495 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 500 505 510 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 515 520 525 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 530 535 540 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 545 550 555 560 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 565 570 575 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 580 585 590 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 595 600 605 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 610 615 620 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu 645 650 655 Thr Gly Pro Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 660 665 670 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 675 680 685 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 690 695 700 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 705 710 715 720 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 725 730 735 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 740 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 755 760 765 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 770 775 780 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 805 810 815 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 820 825 830 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 835 840 845 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 850 855 860 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 865 870 875 880 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 885 890 895 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Pro Ser Ala 900 905 910 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 915 920 925 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 930 935 940 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 945 950 955 960 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 965 970 975 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 980 985 990 Ser Glu Ser Ala Gly Glu Pro Glu Ala 995 1000 <![CDATA[<210> 856]]> <![CDATA[<211> 737]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 856]]> Glu Pro Glu Ala Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Gly Thr 1 5 10 15 Ala Glu Ala Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His 20 25 30 Thr Pro Ala Gly Leu Thr Gly Pro Glu Ala Gly Arg Ser Ala Asn His 35 40 45 Thr Pro Ala Gly Leu Thr Gly Pro Arg Val Ile Pro Val Ser Gly Pro 50 55 60 Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr Asp Asp 65 70 75 80 Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys Thr Ala 85 90 95 Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu 100 105 110 Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala 115 120 125 Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln 130 135 140 Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp 145 150 155 160 Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 165 170 175 Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val Ala 180 185 190 Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg 195 200 205 Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys 210 215 220 Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn 225 230 235 240 Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ser Glu Ser Ala Thr 245 250 255 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 260 265 270 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 275 280 285 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 290 295 300 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 305 310 315 320 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 325 330 335 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 340 345 350 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 355 360 365 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 370 375 380 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 385 390 395 400 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 405 410 415 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 420 425 430 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 435 440 445 Gly Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 450 455 460 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 465 470 475 480 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 485 490 495 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 500 505 510 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 515 520 525 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 530 535 540 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 545 550 555 560 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 565 570 575 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 580 585 590 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 595 600 605 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 610 615 620 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 625 630 635 640 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 645 650 655 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 660 665 670 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 675 680 685 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 690 695 700 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 705 710 715 720 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 725 730 735 Pro <![CDATA[<210> 857]]> <![CDATA[<211> 913]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 857]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 500 505 510 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 515 520 525 Gly Leu Thr Gly Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 530 535 540 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 545 550 555 560 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 565 570 575 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 580 585 590 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 595 600 605 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 610 615 620 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 625 630 635 640 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 645 650 655 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 660 665 670 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 675 680 685 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 690 695 700 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 705 710 715 720 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 725 730 735 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 740 745 750 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 755 760 765 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 770 775 780 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 785 790 795 800 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 805 810 815 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser 820 825 830 Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 835 840 845 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 850 855 860 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 865 870 875 880 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 885 890 895 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Glu Pro Glu 900 905 910 Ala <![CDATA[<210> 858]]> <![CDATA[<211> 737]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 858]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 500 505 510 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 515 520 525 Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 530 535 540 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 545 550 555 560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 565 570 575 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 580 585 590 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 595 600 605 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 610 615 620 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 625 630 635 640 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 645 650 655 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 660 665 670 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 675 680 685 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 690 695 700 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 705 710 715 720 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Glu Pro Glu 725 730 735 Ala <![CDATA[<210> 859]]> <![CDATA[<211> 507]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 859]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 500 505 <![CDATA[<210> 860]]> <![CDATA[<211> 836]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 860]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 500 505 510 Ala Ser Ala Ser Gly Val Leu Gln Ser Pro Gly Thr Ala Glu Ala Ala 515 520 525 Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly 530 535 540 Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 545 550 555 560 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 565 570 575 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 580 585 590 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 595 600 605 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 610 615 620 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 625 630 635 640 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 645 650 655 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 660 665 670 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr 675 680 685 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 690 695 700 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 705 710 715 720 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 725 730 735 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 740 745 750 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 755 760 765 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 770 775 780 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 785 790 795 800 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 805 810 815 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 820 825 830 Gly Ser Ala Pro 835 <![CDATA[<210> 861]]> <![CDATA[<211> 821]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 861]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 290 295 300 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 305 310 315 320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 325 330 335 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 340 345 350 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 355 360 365 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 370 375 380 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 385 390 395 400 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 405 410 415 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 420 425 430 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 435 440 445 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 450 455 460 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 465 470 475 480 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 485 490 495 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 500 505 510 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 515 520 525 Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 530 535 540 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 545 550 555 560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 565 570 575 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 580 585 590 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 595 600 605 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 610 615 620 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 625 630 635 640 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 645 650 655 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 660 665 670 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 675 680 685 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 690 695 700 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 705 710 715 720 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 725 730 735 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 740 745 750 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 755 760 765 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 770 775 780 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 785 790 795 800 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 805 810 815 Glu Gly Ser Ala Pro 820 <![CDATA[<210> 862]]> <![CDATA[<211> 1109]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 862]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 435 440 445 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Arg Val Ile Pro Val Ser 450 455 460 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr Thr 465 470 475 480 Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr Ser Cys 485 490 495 Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp Gln Thr Ser 500 505 510 Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys Asn Glu Ser Cys 515 520 525 Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro 530 535 540 Pro Gln Lys Thr Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr 545 550 555 560 Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala 565 570 575 Leu Gln Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu 580 585 590 Val Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 595 600 605 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val Lys 610 615 620 Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val Val Thr 625 630 635 640 Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Glu Ala 645 650 655 Ala Ser Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala 660 665 670 Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 675 680 685 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 690 695 700 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 705 710 715 720 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 725 730 735 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 740 745 750 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 755 760 765 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 770 775 780 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 785 790 795 800 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 805 810 815 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 820 825 830 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 835 840 845 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 850 855 860 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 865 870 875 880 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 885 890 895 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 900 905 910 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 915 920 925 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 930 935 940 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 945 950 955 960 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 965 970 975 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 980 985 990 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 995 1000 1005 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1010 1015 1020 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1025 1030 1035 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 1040 1045 1050 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 1055 1060 1065 Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1070 1075 1080 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1085 1090 1095 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1100 1105 <![CDATA[<210> 863]]> <![CDATA[<211> 721]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 863]]> Ala Ser Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1 5 10 15 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 20 25 30 Gly Pro Gly Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Gly Thr 35 40 45 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 50 55 60 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 65 70 75 80 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 85 90 95 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 100 105 110 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 115 120 125 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 130 135 140 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 145 150 155 160 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 165 170 175 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 180 185 190 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 195 200 205 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 210 215 220 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 225 230 235 240 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 245 250 255 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 260 265 270 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 275 280 285 Ser Glu Ser Ala Thr Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro 290 295 300 Ala Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 305 310 315 320 Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg 325 330 335 Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys 340 345 350 Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile 355 360 365 Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu 370 375 380 His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr 385 390 395 400 Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 405 410 415 Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu Phe 420 425 430 Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln Ile Ile 435 440 445 Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met Gln Ser Leu 450 455 460 Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro Val Gly Glu Ala 465 470 475 480 Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe 485 490 495 Ser Thr Arg Val Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser 500 505 510 Ala Gly Thr Ala Thr Pro Glu Ser Gly Pro Gly Glu Ala Gly Arg Ser 515 520 525 Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro Ala Thr Pro Glu Ser 530 535 540 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 565 570 575 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 580 585 590 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 610 615 620 Thr Pro Glu Ser Gly Pro Gly Thr Ser Ala Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 645 650 655 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 660 665 670 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 675 680 685 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 690 695 700 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 705 710 715 720 Gly <![CDATA[<210> 864]]> <![CDATA[<211> 1203]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 864]]> Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 1 5 10 15 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 20 25 30 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 35 40 45 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 50 55 60 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 65 70 75 80 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 85 90 95 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 100 105 110 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 115 120 125 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 130 135 140 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 145 150 155 160 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 165 170 175 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 180 185 190 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 195 200 205 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 210 215 220 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 225 230 235 240 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 245 250 255 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 260 265 270 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 275 280 285 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 290 295 300 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Glu Ala Ala Ser 305 310 315 320 Ala Ser Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu 325 330 335 Thr Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 340 345 350 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu 355 360 365 Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 370 375 380 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 385 390 395 400 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 405 410 415 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 420 425 430 Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 435 440 445 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 450 455 460 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 465 470 475 480 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 485 490 495 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu 500 505 510 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 515 520 525 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 530 535 540 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 545 550 555 560 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 565 570 575 Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 580 585 590 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 595 600 605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 610 615 620 Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 625 630 635 640 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 645 650 655 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 660 665 670 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 675 680 685 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 690 695 700 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 705 710 715 720 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 725 730 735 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 740 745 750 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 755 760 765 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 770 775 780 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 785 790 795 800 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 805 810 815 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 820 825 830 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 835 840 845 Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser 850 855 860 Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 865 870 875 880 Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser 885 890 895 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 900 905 910 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 915 920 925 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 930 935 940 Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 945 950 955 960 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 965 970 975 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 980 985 990 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 995 1000 1005 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 1010 1015 1020 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 1025 1030 1035 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 1040 1045 1050 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 1055 1060 1065 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1070 1075 1080 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 1085 1090 1095 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 1100 1105 1110 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser 1115 1120 1125 Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1130 1135 1140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1145 1150 1155 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr 1160 1165 1170 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1175 1180 1185 Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 1190 1195 1200 <![CDATA[<210> 865]]> <![CDATA[<211> 1411]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 865]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro 865 870 875 880 Gly Thr Ala Glu Ala Ala Ser Ala Ser Gly Met Trp Glu Leu Glu Lys 885 890 895 Asp Val Tyr Val Val Glu Val Asp Trp Thr Pro Asp Ala Pro Gly Glu 900 905 910 Thr Val Asn Leu Thr Cys Asp Thr Pro Glu Glu Asp Asp Ile Thr Trp 915 920 925 Thr Ser Asp Gln Arg His Gly Val Ile Gly Ser Gly Lys Thr Leu Thr 930 935 940 Ile Thr Val Lys Glu Phe Leu Asp Ala Gly Gln Tyr Thr Cys His Lys 945 950 955 960 Gly Gly Glu Thr Leu Ser His Ser His Leu Leu Leu His Lys Lys Glu 965 970 975 Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys Asn Phe Lys Asn Lys Thr 980 985 990 Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser Gly Arg Phe Thr Cys Ser 995 1000 1005 Trp Leu Val Gln Arg Asn Met Asp Leu Lys Phe Asn Ile Lys Ser 1010 1015 1020 Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr Cys Gly Met Ala 1025 1030 1035 Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg Asp Tyr Glu 1040 1045 1050 Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro Thr Ala 1055 1060 1065 Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln Gln 1070 1075 1080 Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 1085 1090 1095 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys 1100 1105 1110 Asn Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser 1115 1120 1125 Thr Pro His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln 1130 1135 1140 Arg Lys Lys Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln 1145 1150 1155 Lys Gly Ala Phe Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys 1160 1165 1170 Lys Gly Gly Asn Val Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn 1175 1180 1185 Ser Ser Cys Ser Lys Trp Ala Cys Val Pro Cys Arg Val Arg Ser 1190 1195 1200 Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser 1205 1210 1215 Arg Val Ile Pro Val Ser Gly Pro Ala Arg Cys Leu Ser Gln Ser 1220 1225 1230 Arg Asn Leu Leu Lys Thr Thr Asp Asp Met Val Lys Thr Ala Arg 1235 1240 1245 Glu Lys Leu Lys His Tyr Ser Cys Thr Ala Glu Asp Ile Asp His 1250 1255 1260 Glu Asp Ile Thr Arg Asp Gln Thr Ser Thr Leu Lys Thr Cys Leu 1265 1270 1275 Pro Leu Glu Leu His Lys Asn Glu Ser Cys Leu Ala Thr Arg Glu 1280 1285 1290 Thr Ser Ser Thr Thr Arg Gly Ser Cys Leu Pro Pro Gln Lys Thr 1295 1300 1305 Ser Leu Met Met Thr Leu Cys Leu Gly Ser Ile Tyr Glu Asp Leu 1310 1315 1320 Lys Met Tyr Gln Thr Glu Phe Gln Ala Ile Asn Ala Ala Leu Gln 1325 1330 1335 Asn His Asn His Gln Gln Ile Ile Leu Asp Lys Gly Met Leu Val 1340 1345 1350 Ala Ile Asp Glu Leu Met Gln Ser Leu Asn His Asn Gly Glu Thr 1355 1360 1365 Leu Arg Gln Lys Pro Pro Val Gly Glu Ala Asp Pro Tyr Arg Val 1370 1375 1380 Lys Met Lys Leu Cys Ile Leu Leu His Ala Phe Ser Thr Arg Val 1385 1390 1395 Val Thr Ile Asn Arg Val Met Gly Tyr Leu Ser Ser Ala 1400 1405 1410 <![CDATA[<210> 866]]> <![CDATA[<211> 1722]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 866]]> Ala Ser Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 1 5 10 15 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 20 25 30 Gly Pro Gly Ser Gly Pro Ala Thr Ser Glu Ser Ala Thr Pro Gly Thr 35 40 45 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 50 55 60 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 65 70 75 80 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 85 90 95 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 100 105 110 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 115 120 125 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 130 135 140 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 145 150 155 160 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 165 170 175 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 180 185 190 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 195 200 205 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 210 215 220 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 225 230 235 240 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 245 250 255 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 260 265 270 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 275 280 285 Ser Glu Ser Ala Thr Pro Glu Ala Gly Arg Ser Ala Asn His Thr Pro 290 295 300 Ala Gly Leu Thr Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 305 310 315 320 Met Trp Glu Leu Glu Lys Asp Val Tyr Val Val Glu Val Asp Trp Thr 325 330 335 Pro Asp Ala Pro Gly Glu Thr Val Asn Leu Thr Cys Asp Thr Pro Glu 340 345 350 Glu Asp Asp Ile Thr Trp Thr Ser Asp Gln Arg His Gly Val Ile Gly 355 360 365 Ser Gly Lys Thr Leu Thr Ile Thr Val Lys Glu Phe Leu Asp Ala Gly 370 375 380 Gln Tyr Thr Cys His Lys Gly Gly Glu Thr Leu Ser His Ser His Leu 385 390 395 400 Leu Leu His Lys Lys Glu Asn Gly Ile Trp Ser Thr Glu Ile Leu Lys 405 410 415 Asn Phe Lys Asn Lys Thr Phe Leu Lys Cys Glu Ala Pro Asn Tyr Ser 420 425 430 Gly Arg Phe Thr Cys Ser Trp Leu Val Gln Arg Asn Met Asp Leu Lys 435 440 445 Phe Asn Ile Lys Ser Ser Ser Ser Ser Pro Asp Ser Arg Ala Val Thr 450 455 460 Cys Gly Met Ala Ser Leu Ser Ala Glu Lys Val Thr Leu Asp Gln Arg 465 470 475 480 Asp Tyr Glu Lys Tyr Ser Val Ser Cys Gln Glu Asp Val Thr Cys Pro 485 490 495 Thr Ala Glu Glu Thr Leu Pro Ile Glu Leu Ala Leu Glu Ala Arg Gln 500 505 510 Gln Asn Lys Tyr Glu Asn Tyr Ser Thr Ser Phe Phe Ile Arg Asp Ile 515 520 525 Ile Lys Pro Asp Pro Pro Lys Asn Leu Gln Met Lys Pro Leu Lys Asn 530 535 540 Ser Gln Val Glu Val Ser Trp Glu Tyr Pro Asp Ser Trp Ser Thr Pro 545 550 555 560 His Ser Tyr Phe Ser Leu Lys Phe Phe Val Arg Ile Gln Arg Lys Lys 565 570 575 Glu Lys Met Lys Glu Thr Glu Glu Gly Cys Asn Gln Lys Gly Ala Phe 580 585 590 Leu Val Glu Lys Thr Ser Thr Glu Val Gln Cys Lys Gly Gly Asn Val 595 600 605 Cys Val Gln Ala Gln Asp Arg Tyr Tyr Asn Ser Ser Cys Ser Lys Trp 610 615 620 Ala Cys Val Pro Cys Arg Val Arg Ser Gly Thr Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu 645 650 655 Thr Gly Pro Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 660 665 670 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 675 680 685 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 690 695 700 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 705 710 715 720 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 725 730 735 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 740 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 755 760 765 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 770 775 780 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 805 810 815 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 820 825 830 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 835 840 845 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 850 855 860 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 865 870 875 880 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 885 890 895 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Pro Ser Ala 900 905 910 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 915 920 925 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 930 935 940 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 945 950 955 960 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 965 970 975 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 980 985 990 Ser Glu Ser Ala Gly Ala Ser Ser Ala Thr Pro Glu Ser Gly Pro Gly 995 1000 1005 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1010 1015 1020 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Gly Pro Gly Thr Ser 1025 1030 1035 Glu Ser Ala Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1040 1045 1050 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1055 1060 1065 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 1070 1075 1080 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 1085 1090 1095 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1100 1105 1110 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 1115 1120 1125 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala 1130 1135 1140 Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 1145 1150 1155 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 1160 1165 1170 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 1175 1180 1185 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu 1190 1195 1200 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 1205 1210 1215 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 1220 1225 1230 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly 1235 1240 1245 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 1250 1255 1260 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro Ala Thr Ser 1265 1270 1275 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ala 1280 1285 1290 Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu Thr Gly Pro Gly 1295 1300 1305 Thr Ser Glu Ser Ala Thr Pro Glu Ser Arg Val Ile Pro Val Ser 1310 1315 1320 Gly Pro Ala Arg Cys Leu Ser Gln Ser Arg Asn Leu Leu Lys Thr 1325 1330 1335 Thr Asp Asp Met Val Lys Thr Ala Arg Glu Lys Leu Lys His Tyr 1340 1345 1350 Ser Cys Thr Ala Glu Asp Ile Asp His Glu Asp Ile Thr Arg Asp 1355 1360 1365 Gln Thr Ser Thr Leu Lys Thr Cys Leu Pro Leu Glu Leu His Lys 1370 1375 1380 Asn Glu Ser Cys Leu Ala Thr Arg Glu Thr Ser Ser Thr Thr Arg 1385 1390 1395 Gly Ser Cys Leu Pro Pro Gln Lys Thr Ser Leu Met Met Thr Leu 1400 1405 1410 Cys Leu Gly Ser Ile Tyr Glu Asp Leu Lys Met Tyr Gln Thr Glu 1415 1420 1425 Phe Gln Ala Ile Asn Ala Ala Leu Gln Asn His Asn His Gln Gln 1430 1435 1440 Ile Ile Leu Asp Lys Gly Met Leu Val Ala Ile Asp Glu Leu Met 1445 1450 1455 Gln Ser Leu Asn His Asn Gly Glu Thr Leu Arg Gln Lys Pro Pro 1460 1465 1470 Val Gly Glu Ala Asp Pro Tyr Arg Val Lys Met Lys Leu Cys Ile 1475 1480 1485 Leu Leu His Ala Phe Ser Thr Arg Val Val Thr Ile Asn Arg Val 1490 1495 1500 Met Gly Tyr Leu Ser Ser Ala Gly Thr Ala Thr Pro Glu Ser Gly 1505 1510 1515 Pro Gly Glu Ala Gly Arg Ser Ala Asn His Thr Pro Ala Gly Leu 1520 1525 1530 Thr Gly Pro Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala 1535 1540 1545 Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 1550 1555 1560 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1565 1570 1575 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 1580 1585 1590 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser 1595 1600 1605 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 1610 1615 1620 Glu Ser Gly Pro Gly Thr Ser Ala Ser Ala Thr Pro Glu Ser Gly 1625 1630 1635 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 1640 1645 1650 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 1655 1660 1665 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 1670 1675 1680 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1685 1690 1695 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1700 1705 1710 Ser Glu Ser Ala Gly Glu Pro Glu Ala 1715 1720 <![CDATA[<210> 867]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 867]]> Leu Glu Val Leu Phe Gln Gly Pro 1 5 <![CDATA[<210> 868]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 868]]> Leu Pro Lys Thr Gly Ser Glu Ser 1 5 <![CDATA[<210> 869]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(1)]]> <![CDATA[<223> Xaa為K或D]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (2)..(2)]]> <![CDATA[<223> Xaa為F或L]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(5)]]> <![CDATA[<223> Xaa為V或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為V或E]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為G或T]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (8)..(8)]]> <![CDATA[<223> Xaa為G或V]]> <![CDATA[<400> 869]]> Xaa Xaa Thr Arg Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 870]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(2)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為F或L]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (4)..(4)]]> <![CDATA[<223> Xaa為R或Y]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(5)]]> <![CDATA[<223> Xaa為R或S]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為R或T]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 870]]> Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 871]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(2)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 871]]> Xaa Xaa Gly Arg Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 872]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(1)]]> <![CDATA[<223> Xaa為I或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為G、F或P]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(5)]]> <![CDATA[<223> Xaa為S、T或I]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為V、F或S]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 872]]> Xaa Glu Xaa Arg Xaa Xaa Xaa Gly 1 5 <![CDATA[<210> 873]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(2)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為P、L或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(5)]]> <![CDATA[<223> Xaa為S、G或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 873]]> Xaa Xaa Xaa Arg Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 874]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(3)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (4)..(4)]]> <![CDATA[<223> Xaa為V、I、A或T]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 874]]> Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 875]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (2)..(3)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 875]]> Val Xaa Xaa Asp Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 876]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (2)..(2)]]> <![CDATA[<223> Xaa為P或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (8)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 876]]> Gly Xaa Xaa Gly Leu Xaa Gly Xaa 1 5 <![CDATA[<210> 877]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為G或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為G或A]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (8)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 877]]> Gly Pro Xaa Gly Leu Xaa Xaa Xaa 1 5 <![CDATA[<210> 878]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (1)..(1)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (2)..(2)]]> <![CDATA[<223> Xaa為P或S]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (4)..(4)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (5)..(5)]]> <![CDATA[<223> Xaa為L或Q]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為L或T]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (8)..(8)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<400> 878]]> Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa 1 5 <![CDATA[<210> 879]]> <![CDATA[<211> 7]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為G或S]]> <![CDATA[<400> 879]]> Glu Asn Leu Tyr Gly Gln Xaa 1 5 <![CDATA[<210> 880]]> <![CDATA[<211> 8]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (3)..(3)]]> <![CDATA[<223> Xaa為K、E、A或D]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (6)..(6)]]> <![CDATA[<223> Xaa為任何胺基酸]]> <![CDATA[<220>]]> <![CDATA[<221> MISC_FEATURE]]> <![CDATA[<222> (7)..(7)]]> <![CDATA[<223> Xaa為E、K或S]]> <![CDATA[<400> 880]]> Leu Pro Xaa Thr Gly Xaa Xaa Ser 1 5 <![CDATA[<210> 881]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 881]]> Gly Ser Gly Ala Ser Glu Pro Thr Ser Thr Glu Pro 1 5 10 <![CDATA[<210> 882]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 882]]> Gly Ser Glu Pro Ala Thr Ser Gly Thr Glu Pro Ser 1 5 10 <![CDATA[<210> 883]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 883]]> Gly Thr Ser Glu Pro Ser Thr Ser Glu Pro Gly Ala 1 5 10 <![CDATA[<210> 884]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 884]]> Gly Thr Ser Thr Glu Pro Ser Glu Pro Gly Ser Ala 1 5 10 <![CDATA[<210> 885]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 885]]> Gly Ser Thr Ala Gly Ser Glu Thr Ser Thr Glu Ala 1 5 10 <![CDATA[<210> 886]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 886]]> Gly Ser Glu Thr Ala Thr Ser Gly Ser Glu Thr Ala 1 5 10 <![CDATA[<210> 887]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 887]]> Gly Thr Ser Glu Ser Ala Thr Ser Glu Ser Gly Ala 1 5 10 <![CDATA[<210> 888]]> <![CDATA[<211> 12]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 888]]> Gly Thr Ser Thr Glu Ala Ser Glu Gly Ser Ala Ser 1 5 10 <![CDATA[<210> 889]]> <![CDATA[<211> 874]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 889]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 35 40 45 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 65 70 75 80 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 85 90 95 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 165 170 175 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 290 295 300 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 305 310 315 320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 355 360 365 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 435 440 445 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 485 490 495 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 515 520 525 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 530 535 540 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 580 585 590 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 625 630 635 640 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 645 650 655 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 660 665 670 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 675 680 685 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 705 710 715 720 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 740 745 750 Pro Glu Ser Gly Pro Gly Phe Thr Ala Asx Thr Ser Glu Ser Ala Thr 755 760 765 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Pro Thr Glu 770 775 780 Ser Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 785 790 795 800 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 805 810 815 Glu Gly Ser Ala Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala 820 825 830 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 835 840 845 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 850 855 860 Glu Gly Ser Ala Pro Gly Glu Pro Glu Ala 865 870 <![CDATA[<210> 890]]> <![CDATA[<211> 870]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 890]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 35 40 45 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 65 70 75 80 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 85 90 95 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 165 170 175 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 290 295 300 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 305 310 315 320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 355 360 365 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 435 440 445 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 485 490 495 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 515 520 525 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 530 535 540 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 580 585 590 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 625 630 635 640 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 645 650 655 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 660 665 670 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 675 680 685 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 705 710 715 720 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 740 745 750 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 755 760 765 Pro Gly Ser Glu Pro Ala Thr Ser Gly Pro Thr Glu Ser Gly Ser Glu 770 775 780 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 785 790 795 800 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 805 810 815 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 820 825 830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 835 840 845 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 850 855 860 Pro Gly Glu Pro Glu Ala 865 870 <![CDATA[<210> 891]]> <![CDATA[<211> 870]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 891]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 35 40 45 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 65 70 75 80 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 85 90 95 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 165 170 175 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 290 295 300 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 305 310 315 320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 355 360 365 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 435 440 445 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 485 490 495 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 515 520 525 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 530 535 540 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 580 585 590 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 625 630 635 640 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 645 650 655 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 660 665 670 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 675 680 685 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 705 710 715 720 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 740 745 750 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 755 760 765 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 770 775 780 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 785 790 795 800 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 805 810 815 Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 820 825 830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 835 840 845 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 850 855 860 Pro Gly Glu Pro Glu Ala 865 870 <![CDATA[<210> 892]]> <![CDATA[<211> 294]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 892]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Glu Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro 290 <![CDATA[<210> 893]]> <![CDATA[<211> 294]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 893]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Ser Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro 290 <![CDATA[<210> 894]]> <![CDATA[<211> 294]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 894]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Glu Glu Pro Ala Thr Ser Gly Ser Thr Pro 130 135 140 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro 290 <![CDATA[<210> 895]]> <![CDATA[<211> 294]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 895]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro 290 <![CDATA[<210> 896]]> <![CDATA[<211> 866]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 896]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 35 40 45 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 65 70 75 80 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 85 90 95 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 165 170 175 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 245 250 255 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 275 280 285 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 290 295 300 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 305 310 315 320 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 325 330 335 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 355 360 365 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 370 375 380 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 385 390 395 400 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 420 425 430 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 435 440 445 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 465 470 475 480 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 485 490 495 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 500 505 510 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 515 520 525 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 530 535 540 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 580 585 590 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 595 600 605 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 610 615 620 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 625 630 635 640 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 645 650 655 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 660 665 670 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 675 680 685 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 690 695 700 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 705 710 715 720 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 725 730 735 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 740 745 750 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 755 760 765 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 770 775 780 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 785 790 795 800 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 805 810 815 Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 820 825 830 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 835 840 845 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 850 855 860 Pro Gly 865 <![CDATA[<210> 897]]> <![CDATA[<211> 578]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 897]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 20 25 30 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 65 70 75 80 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 100 105 110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 115 120 125 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 145 150 155 160 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 225 230 235 240 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 290 295 300 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 305 310 315 320 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 325 330 335 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 355 360 365 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 370 375 380 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 385 390 395 400 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 420 425 430 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 435 440 445 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 465 470 475 480 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 485 490 495 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 500 505 510 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 515 520 525 Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 530 535 540 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly <![CDATA[<210> 898]]> <![CDATA[<211> 1152]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 898]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Thr Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 245 250 255 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 260 265 270 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 290 295 300 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 340 345 350 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 370 375 380 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 385 390 395 400 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 405 410 415 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 420 425 430 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 435 440 445 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 465 470 475 480 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 500 505 510 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 530 535 540 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 545 550 555 560 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 565 570 575 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 580 585 590 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 595 600 605 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 610 615 620 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 625 630 635 640 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 645 650 655 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 660 665 670 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 675 680 685 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 690 695 700 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser 705 710 715 720 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 725 730 735 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 740 745 750 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 755 760 765 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 770 775 780 Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 785 790 795 800 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro 805 810 815 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 820 825 830 Ala Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 835 840 845 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 850 855 860 Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 865 870 875 880 Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 885 890 895 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 900 905 910 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 915 920 925 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 930 935 940 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 945 950 955 960 Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 1040 1045 1050 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 1085 1090 1095 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 1100 1105 1110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 1115 1120 1125 Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 1130 1135 1140 Ser Gly Pro Gly Thr Glu Ser Ala Ser 1145 1150 <![CDATA[<210> 899]]> <![CDATA[<211> 1153]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 899]]> Ser Ala Gly Ser Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 35 40 45 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 85 90 95 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 225 230 235 240 Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 245 250 255 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 260 265 270 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 275 280 285 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 290 295 300 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 305 310 315 320 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 325 330 335 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 340 345 350 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 355 360 365 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 370 375 380 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 385 390 395 400 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 405 410 415 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 420 425 430 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 435 440 445 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 450 455 460 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 465 470 475 480 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 485 490 495 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 500 505 510 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 515 520 525 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 530 535 540 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 545 550 555 560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 565 570 575 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 580 585 590 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 595 600 605 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 610 615 620 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 625 630 635 640 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 645 650 655 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 660 665 670 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 675 680 685 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 690 695 700 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 705 710 715 720 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 725 730 735 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 740 745 750 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 755 760 765 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 770 775 780 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 785 790 795 800 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 805 810 815 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 820 825 830 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 835 840 845 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 850 855 860 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 865 870 875 880 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 885 890 895 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 900 905 910 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 915 920 925 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 930 935 940 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 945 950 955 960 Gly Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu 965 970 975 Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 980 985 990 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro 995 1000 1005 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1010 1015 1020 Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 1025 1030 1035 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ala 1040 1045 1050 Thr Glu Ser Pro Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 1055 1060 1065 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 1070 1075 1080 Ser Ala Pro Gly Thr Ser Ala Glu Ser Ala Thr Pro Glu Ser Gly 1085 1090 1095 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 1100 1105 1110 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu 1115 1120 1125 Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 1130 1135 1140 Glu Ser Gly Pro Gly Thr Glu Ser Ala Ser 1145 1150 <![CDATA[<210> 900]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 900]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Ala Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Ser Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <![CDATA[<210> 901]]> <![CDATA[<211> 864]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 901]]> Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 20 25 30 Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 35 40 45 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 50 55 60 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 65 70 75 80 Glu Ser Gly Pro Gly Ser Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro 85 90 95 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala 100 105 110 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 115 120 125 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 145 150 155 160 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 165 170 175 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 195 200 205 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 225 230 235 240 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 245 250 255 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 275 280 285 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 290 295 300 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 305 310 315 320 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 340 345 350 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 370 375 380 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 385 390 395 400 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 405 410 415 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 420 425 430 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 435 440 445 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 450 455 460 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 465 470 475 480 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 485 490 495 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro 500 505 510 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 515 520 525 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala 530 535 540 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro 545 550 555 560 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 565 570 575 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 580 585 590 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 595 600 605 Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 610 615 620 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr 625 630 635 640 Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr 645 650 655 Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 660 665 670 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 675 680 685 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 690 695 700 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 705 710 715 720 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 725 730 735 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 740 745 750 Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 755 760 765 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu Pro 770 775 780 Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr 785 790 795 800 Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 805 810 815 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu Pro 820 825 830 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 835 840 845 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 850 855 860 <![CDATA[<210> 902]]> <![CDATA[<211> 292]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 902]]> Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser Glu Ser 1 5 10 15 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly 20 25 30 Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 35 40 45 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser 50 55 60 Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser Gly Ser 65 70 75 80 Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly 85 90 95 Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly 100 105 110 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu 115 120 125 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 130 135 140 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly 145 150 155 160 Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser 165 170 175 Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 180 185 190 Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser 195 200 205 Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu 210 215 220 Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly 225 230 235 240 Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly 245 250 255 Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly 260 265 270 Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly 275 280 285 Gly Ser Ala Pro 290 <![CDATA[<210> 903]]> <![CDATA[<211> 582]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 903]]> Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 20 25 30 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 50 55 60 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 65 70 75 80 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 100 105 110 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 115 120 125 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 145 150 155 160 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 165 170 175 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 225 230 235 240 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 260 265 270 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 290 295 300 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 305 310 315 320 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 325 330 335 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 340 345 350 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 355 360 365 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 370 375 380 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 385 390 395 400 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 405 410 415 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 420 425 430 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 435 440 445 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 450 455 460 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 465 470 475 480 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Glu 485 490 495 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro 500 505 510 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 515 520 525 Pro Gly Thr Glu Ser Thr Pro Ser Glu Gly Ser Ala Pro Gly Ser Glu 530 535 540 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 545 550 555 560 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 565 570 575 Pro Gly Glu Pro Glu Ala 580 <![CDATA[<210> 904]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 904]]> Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 1 5 10 15 Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr 20 25 30 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr 35 40 45 Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 50 55 60 Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 65 70 75 80 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro 85 90 95 Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 100 105 110 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 115 120 125 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 130 135 140 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 145 150 155 160 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 165 170 175 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 180 185 190 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 195 200 205 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 210 215 220 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala 225 230 235 240 Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 245 250 255 Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser 260 265 270 Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala 275 280 285 Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 290 295 300 Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser 305 310 315 320 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 325 330 335 Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu 340 345 350 Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr 355 360 365 Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser 370 375 380 Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 385 390 395 400 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr 405 410 415 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser 420 425 430 Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr 435 440 445 Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr 450 455 460 Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala 465 470 475 480 Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser 485 490 495 Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser 500 505 510 Glu Ser Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser 515 520 525 Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser 530 535 540 Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser 545 550 555 560 Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala 565 570 575 <![CDATA[<210> 905]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 905]]> Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 1 5 10 15 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 20 25 30 Ser Glu Thr Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro 35 40 45 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 50 55 60 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 65 70 75 80 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 85 90 95 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr 100 105 110 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 115 120 125 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 130 135 140 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 145 150 155 160 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 165 170 175 Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 180 185 190 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 195 200 205 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro 210 215 220 Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 225 230 235 240 Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro 245 250 255 Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro 260 265 270 Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 275 280 285 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr 290 295 300 Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu 305 310 315 320 Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro 325 330 335 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala 340 345 350 Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu 355 360 365 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 370 375 380 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 385 390 395 400 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 405 410 415 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 420 425 430 Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu 435 440 445 Ser Ala Ser Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr 450 455 460 Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu 465 470 475 480 Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu 485 490 495 Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu 500 505 510 Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 515 520 525 Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu 530 535 540 Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly 545 550 555 560 Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro 565 570 575 <![CDATA[<210> 906]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 906]]> Gly Ser Glu Thr Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 1 5 10 15 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 35 40 45 Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 50 55 60 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 85 90 95 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 100 105 110 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 115 120 125 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Thr Glu Pro Ser 130 135 140 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 145 150 155 160 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 165 170 175 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 180 185 190 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 195 200 205 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 210 215 220 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 225 230 235 240 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 245 250 255 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 260 265 270 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 275 280 285 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 290 295 300 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 305 310 315 320 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 325 330 335 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 340 345 350 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 355 360 365 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 370 375 380 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 385 390 395 400 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 405 410 415 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 420 425 430 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 435 440 445 Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 450 455 460 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 465 470 475 480 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Thr Glu 485 490 495 Thr Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 500 505 510 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 515 520 525 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 530 535 540 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 545 550 555 560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 565 570 575 <![CDATA[<210> 907]]> <![CDATA[<211> 576]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 907]]> Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 1 5 10 15 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 20 25 30 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 35 40 45 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 50 55 60 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 65 70 75 80 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 85 90 95 Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 100 105 110 Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser 115 120 125 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser 130 135 140 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 145 150 155 160 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 165 170 175 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser 180 185 190 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 195 200 205 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 210 215 220 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 225 230 235 240 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 245 250 255 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 260 265 270 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 275 280 285 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 290 295 300 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 305 310 315 320 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr 325 330 335 Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 340 345 350 Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro 355 360 365 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 370 375 380 Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 385 390 395 400 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Glu 405 410 415 Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr 420 425 430 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 435 440 445 Pro Gly Thr Ser Glu Ser Ala Ser Pro Glu Ser Gly Pro Gly Thr Ser 450 455 460 Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro Ala Gly Ser Pro 465 470 475 480 Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 485 490 495 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 500 505 510 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro Ala Gly Ser Pro 515 520 525 Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu 530 535 540 Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Thr Ser 545 550 555 560 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 565 570 575 <![CDATA[<210> 908]]> <![CDATA[<211> 294]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 合成]]> <![CDATA[<400> 908]]> Ala Ser Ser Pro Ala Gly Ser Pro Thr Ser Thr Glu Ser Gly Thr Ser 1 5 10 15 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Thr Glu Pro Ser 20 25 30 Glu Gly Ser Ala Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 35 40 45 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Thr Ser 50 55 60 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Thr Pro Ala Glu Ser 65 70 75 80 Gly Ser Glu Thr Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly 85 90 95 Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala Pro Gly Ser Pro 100 105 110 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Glu Ser Ala Thr 115 120 125 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 130 135 140 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Ser Pro 145 150 155 160 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Ser Pro Ala Gly Ser Pro 165 170 175 Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 180 185 190 Pro Gly Thr Ser Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser 195 200 205 Glu Ser Ala Thr Pro Glu Ser Gly Pro Gly Thr Ser Glu Ser Ala Thr 210 215 220 Pro Glu Ser Gly Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr 225 230 235 240 Pro Gly Ser Glu Pro Ala Thr Ser Gly Ser Glu Thr Pro Gly Ser Pro 245 250 255 Ala Gly Ser Pro Thr Ser Thr Glu Glu Gly Thr Ser Thr Glu Pro Ser 260 265 270 Glu Gly Ser Ala Pro Gly Thr Ser Thr Glu Pro Ser Glu Gly Ser Ala 275 280 285 Pro Gly Gly Ser Ala Pro 290 <![CDATA[<210> 909]]> <![CDATA[<211> 5]]> <![CDATA[<212> PRT]]> <![CDATA[<213> 人工序列]]> <![CDATA[<220>]]> <![CDATA[<223> 分選酶A]]> <![CDATA[<400> 909]]> Leu Pro Glu Thr Gly 1 5
Claims (34)
- 一種融合蛋白,其包含: (a) 延伸重組多肽(extended recombinant polypeptide,XTEN),其特徵在於: i. 其包含至少12個胺基酸; ii. XTEN序列之至少90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%的胺基酸殘基係選自甘胺酸(G)、丙胺酸(A)、絲胺酸(S)、蘇胺酸(T)、麩胺酸(E)及脯胺酸(P);及 iii. 其具有4至6個選自G、A、S、T、E及P之不同胺基酸;及 (b) 與至少一個XTEN連接之細胞介素。
- 如請求項1之融合蛋白,其中該融合蛋白包含1、2、3、4或更多個XTEN。
- 如請求項1之融合蛋白,其中該融合蛋白進一步包含腫瘤靶向域。
- 如請求項1之融合蛋白,其進一步包含釋放區段,其中該釋放區段(RS)與選自 表 6 至表 7中所闡述之序列的序列具有至少88%、至少94%或100%序列一致性。
- 如請求項3之融合蛋白,其中該腫瘤靶向域連接至與該細胞介素連接之該等XTEN中之一者。
- 如請求項5之融合蛋白,其中該腫瘤靶向域之C端連接至另一XTEN。
- 如請求項6之融合蛋白,其進一步包含該腫瘤靶向域之C端與該其他XTEN之N端之間的釋放位點。
- 如請求項4之融合蛋白,其中該融合蛋白具有XTEN-RS-細胞介素或細胞介素-RS-XTEN之自N端至C端的結構排列。
- 如請求項1至8中任一項之融合蛋白,其中該細胞介素係選自由介白素、趨化介素、干擾素、腫瘤壞死因子、群落刺激因子或TGF-β超家族成員組成之群。
- 如請求項9之融合蛋白,其中該細胞介素係選自由以下組成之群的介白素:IL1、IL2、IL3、IL4、IL5、IL6、IL7、IL8、IL9、IL10、IL11、IL12、IL13、IL14、IL15、IL16及IL17。
- 如請求項9之融合蛋白,其中該細胞介素與選自 表 3或 表 A之序列具有至少90%序列一致性。
- 如請求項9之融合蛋白,其中該細胞介素為IL-12或IL-12變異體。
- 如請求項12之融合蛋白,其中該細胞介素包含第一細胞介素片段(Cy1)及第二細胞介素片段(Cy2)。
- 如請求項13之融合蛋白,其中該Cy1及該Cy2中之一者包含與介白素-12次單元β具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的胺基酸序列。
- 如請求項14之融合蛋白,其中該Cy1及該Cy2中之另一者包含與介白素-12次單元α具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性的胺基酸序列。
- 如請求項13之融合蛋白,其中該第一細胞介素片段(Cy1)包含與序列 SEQ ID NO. 5具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列。
- 如請求項13之融合蛋白,其中該第二細胞介素片段(Cy2)包含與序列 SEQ ID NO. 6具有至少70%、75%、80%、85%、90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列。
- 如請求項13至17中任一項之融合蛋白,其中該細胞介素包含位於該第一細胞介素片段(Cy1)與該第二細胞介素片段(Cy2)之間的連接子。
- 如請求項18之融合蛋白,其中該融合蛋白包含Cy1片段,該片段包含N端處之XTEN及C端處之XTEN。
- 如請求項18之融合蛋白,其中該融合蛋白包含Cy2片段,該片段包含N端處之XTEN及C端處之XTEN。
- 如請求項18之融合蛋白,其中該細胞介素為包含與 SEQ ID NO. 7具有至少90%、91%、92%、93%、94%、95%、96%、97%、98%、99%或100%序列一致性之胺基酸序列的IL-12變異體。
- 如請求項1至21中任一項之融合蛋白,其中該XTEN序列由多個非重疊序列模體組成,其中該等序列模體選自 表 2 a 至表 2 b之序列模體。
- 如請求項1至22中任一項之融合蛋白,其中該XTEN具有40至3000個胺基酸,或100至3000個胺基酸。
- 如請求項1至23中任一項之融合蛋白,其中該XTEN與 表 2 a 至表 2 b中所闡述之序列具有至少90%、至少91%、至少92%、至少93%、至少94%、至少95%、至少96%、至少97%、至少98%或至少99%或100%序列一致性。
- 如請求項1至24中任一項之融合蛋白,其中當連接至該融合蛋白中之該XTEN時,該細胞介素與相應細胞介素受體之結合活性的特徵在於半最大有效濃度(EC 50)比當未與該XTEN連接時在活體外結合分析中測定之表徵該細胞介素的相應結合活性的EC 50大至少1.2倍、大至少1.4倍、大至少1.6倍、大至少1.8倍、大至少2.0倍、大至少3.0倍、大至少4.0倍、大至少5.0倍、大至少6.0倍、大至少7.0倍、大至少8.0倍、大至少9.0倍或大至少10.0倍。
- 如請求項25之融合蛋白,其中該細胞介素為介白素12(IL-12)且該相應細胞介素受體為介白素12受體(IL-12R)。
- 如請求項25或請求項26之融合蛋白,其中該活體外結合分析利用基因工程改造之報導基因細胞株,該細胞株經組態成以報導蛋白的成比例表現對該細胞介素與該相應細胞介素受體之結合作出反應。
- 一種醫藥組合物,其包含如請求項1至27中任一項之融合蛋白及至少一種醫藥學上可接受之載劑。
- 一種如請求項28之組合物的用途,其用於製備用於治療有需要之個體之疾病或病況的藥劑。
- 如請求項29之用途,其中該疾病或病況係選自癌症、類風濕性關節炎、多發性硬化症、重症肌無力、全身性紅斑狼瘡、阿茲海默氏症(Alzheimer's disease)、精神分裂症、病毒感染、過敏性哮喘、視網膜神經退化性過程、代謝病症、胰島素抗性及糖尿病性心肌症。
- 一種治療或預防個體之疾病或病況的方法,該方法包含向個體投與治療有效量之如請求項1至27中任一項之融合蛋白或如請求項28之組合物。
- 如請求項31之方法,其中該疾病或病況係癌症或癌症相關疾病或病況。
- 如請求項31或請求項32之方法,其進一步包含向該個體投與治療有效量之至少一種免疫檢查點抑制劑。
- 如請求項31至33中任一項之方法,其中該融合蛋白經靜脈內、皮下或經口遞送。
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