TW202241933A - 多肽及其用途 - Google Patents

多肽及其用途 Download PDF

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Publication number
TW202241933A
TW202241933A TW110147305A TW110147305A TW202241933A TW 202241933 A TW202241933 A TW 202241933A TW 110147305 A TW110147305 A TW 110147305A TW 110147305 A TW110147305 A TW 110147305A TW 202241933 A TW202241933 A TW 202241933A
Authority
TW
Taiwan
Prior art keywords
aib
xaa
diacid
amide
cntatc
Prior art date
Application number
TW110147305A
Other languages
English (en)
Chinese (zh)
Inventor
瑪利亞 亞雷山卓 班德那克
西凡尼瓦力 杰納帕西
Original Assignee
英商梅迪繆思有限公司
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 英商梅迪繆思有限公司 filed Critical 英商梅迪繆思有限公司
Publication of TW202241933A publication Critical patent/TW202241933A/zh

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/31Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
TW110147305A 2020-12-16 2021-12-16 多肽及其用途 TW202241933A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202063125996P 2020-12-16 2020-12-16
US63/125,996 2020-12-16

Publications (1)

Publication Number Publication Date
TW202241933A true TW202241933A (zh) 2022-11-01

Family

ID=79287870

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110147305A TW202241933A (zh) 2020-12-16 2021-12-16 多肽及其用途

Country Status (16)

Country Link
US (3) US12371464B2 (https=)
EP (2) EP4736944A2 (https=)
JP (2) JP7767428B2 (https=)
KR (1) KR20230120134A (https=)
CN (1) CN116685599A (https=)
AR (1) AR124391A1 (https=)
AU (2) AU2021399076B2 (https=)
CA (1) CA3204296A1 (https=)
CL (1) CL2023001719A1 (https=)
CO (1) CO2023009066A2 (https=)
CR (1) CR20230311A (https=)
EC (1) ECSP23052600A (https=)
IL (1) IL303578A (https=)
MX (1) MX2023007288A (https=)
TW (1) TW202241933A (https=)
WO (1) WO2022129254A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CR20230311A (es) 2020-12-16 2023-09-01 Medimmune Ltd Polipéptidos y usos de los mismos
CA3204051A1 (en) 2021-01-20 2022-07-28 Brian Lian Compositions and methods for the treatment of metabolic and liver disorders
JP7642830B2 (ja) 2021-09-15 2025-03-10 バイキング・セラピューティクス・インコーポレイテッド 代謝及び肝臓障害の処置のための組成物及び方法
US12116388B2 (en) 2022-12-22 2024-10-15 Novo Nordisk A/S Amylin receptor agonists
IL322661A (en) * 2023-02-10 2025-10-01 Hangzhou Sciwind Biosciences Co Ltd Polypeptide and its history, composition containing them and their use
TW202540155A (zh) 2023-11-30 2025-10-16 丹麥商諾佛 儂迪克股份有限公司 Glp-1、gip及澱粉素受體之三重促效劑
WO2025147628A2 (en) * 2024-01-05 2025-07-10 Indiana University Research And Technology Corporation Dual amylin calcitonin receptor agonists
WO2025242620A1 (en) 2024-05-20 2025-11-27 Medimmune Limited Polypeptide combinations and uses thereof
WO2026058194A1 (en) 2024-09-12 2026-03-19 Medimmune Limited Polypeptide dosage regimens

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102004051014A1 (de) * 2004-10-20 2006-04-27 Rwth Aachen Chemisch modifizierte Peptidanaloga
JP5252435B2 (ja) * 2006-03-15 2013-07-31 ノボ・ノルデイスク・エー/エス アミリン誘導体
EP2036923A1 (en) * 2007-09-11 2009-03-18 Novo Nordisk A/S Improved derivates of amylin
ES2662501T3 (es) * 2008-10-21 2018-04-06 Novo Nordisk A/S Derivados de amilina
US9205135B2 (en) * 2009-09-22 2015-12-08 University Of Miami Podocyte pH modulation and uses thereof
US20140249076A1 (en) 2011-10-18 2014-09-04 Astrazeneca Pharmaceuticals Lp Amylin-calcitonin chimeric peptides conjugated to duration enhancing moieties
CN105849123A (zh) * 2013-12-13 2016-08-10 免疫医疗有限公司 蛋白酶抗性肽
JP6730278B2 (ja) * 2014-11-27 2020-07-29 ノヴォ ノルディスク アー/エス Glp−1誘導体及びその使用
AR116632A1 (es) * 2018-10-11 2021-05-26 Intarcia Therapeutics Inc Polipéptidos análogos de la amilina humana y sus métodos de uso
WO2020225781A1 (en) * 2019-05-08 2020-11-12 Auckland Uniservices Limited Peptide conjugate amylin agonists and uses thereof
CR20230311A (es) 2020-12-16 2023-09-01 Medimmune Ltd Polipéptidos y usos de los mismos

Also Published As

Publication number Publication date
ECSP23052600A (es) 2023-08-31
AU2024227071A1 (en) 2024-10-24
JP7767428B2 (ja) 2025-11-11
CO2023009066A2 (es) 2023-07-10
WO2022129254A1 (en) 2022-06-23
US20220204580A1 (en) 2022-06-30
CA3204296A1 (en) 2022-06-23
KR20230120134A (ko) 2023-08-16
JP2023554046A (ja) 2023-12-26
JP2026031965A (ja) 2026-02-25
EP4263586B1 (en) 2026-03-11
AU2021399076B2 (en) 2024-07-11
US12371464B2 (en) 2025-07-29
AR124391A1 (es) 2023-03-22
IL303578A (en) 2023-08-01
MX2023007288A (es) 2023-07-03
AU2021399076A9 (en) 2024-07-18
CL2023001719A1 (es) 2024-01-26
US20250289860A1 (en) 2025-09-18
CN116685599A (zh) 2023-09-01
AU2021399076A1 (en) 2023-07-27
CR20230311A (es) 2023-09-01
US20240067693A1 (en) 2024-02-29
EP4263586A1 (en) 2023-10-25
EP4736944A2 (en) 2026-05-06

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