TW202228602A - Medicinal liquid injection device for living body - Google Patents

Abstract

The present invention provides a medicinal liquid injection device for a living body capable of spraying medicinal liquid into a body cavity in the form of finer particles. The medicinal liquid injection device for a living body has a nozzle comprising a tubular medicinal liquid ejection part (ejection pipe (13)) which is provided at a tip-end (head (12)) of the nozzle and ejects medicinal liquid from an internal space thereof, and a gas emission part (12f) which is located in the vicinity of the ejection pipe (13) and sprays the medicinal liquid in the form of a fine mist by jetting gas toward the medicinal liquid ejected from the ejection pipe (13). In the ejection pipe (13), an inflow opening (slit (13b)) is formed on the gas emission part (12f) side, and an outflow opening (slit (13c)) is formed on a side opposite the gas emission part (12f) side. The gas emission part (12f) jets blow gas in a direction crossing the ejection direction of the medicinal liquid ejected from the ejection pipe (13). The slits (13b), (13c) are formed on an extension of the direction of jetting of blow gas (G) by the gas emission part (12f).

Description

Biological liquid injection equipment

The present invention relates to a biomedical solution injection tool for spraying a medical solution to an affected part of a living body.

In the treatment or treatment in a living body, generally, a trocar is passed through a hole formed in the abdomen or the like, and a nozzle is passed through the trocar to introduce a medicinal solution into a body cavity. In addition, Patent Document 1 discloses a technique for spraying a chemical solution over a wide range using a nozzle even in a state where the nozzle is restricted in arrangement by a trocar.

The device for injecting a biological chemical solution described in Patent Document 1 (described in this document as a device for applying a biological tissue adhesive.) It is possible to inject a plurality of chemical solutions and a gas that mixes these chemical solutions with respect to the axis of the nozzle. Spray in an oblique direction. In this way, if the chemical liquid is sprayed obliquely with respect to the axial direction of the nozzle, the chemical liquid can be sprayed over a wide range by rotating the nozzle around the axial center. [Prior Art Literature] [Patent Documents]

Patent Document 1: Japanese Patent Laid-Open No. 2013-74988

[Problems to be Solved by Invention]

In the biomedical solution injection device disclosed in Patent Document 1, the distal ends of both the gas ejection channel and the medical solution flow channel are formed inclined with respect to the axial direction of the nozzle, thereby spraying the medical solution and the gas. In addition, in this biomedical solution spraying device, when gas is supplied to the medical solution at a high pressure (for example, 0.1 MPa), it is necessary to prevent a sheet such as a tissue adhesive sheet to be sprayed due to the wind pressure. position offset. When reducing the gas supply pressure (for example, 0.07 MPa) in order to prevent this positional displacement, the gas reduces the particle size of the chemical solution, makes it easier to mix multiple chemical solutions, and effectively applies the chemical solution to the downwind. There is still room for improvement.

The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to provide a biomedical solution injector that can spray a medical solution into a body cavity in finer granules. [How to solve the problem]

The biomedical solution injection device of the present invention is characterized by comprising: a main body part; and a nozzle extending from the main body part; liquid; and a gas ejection part, located in the vicinity of the liquid medicine ejection part, by spraying gas to the liquid medicine ejected from the liquid medicine ejection part, the liquid medicine is sprayed in a mist form; on the peripheral wall of the liquid medicine ejection part, the gas is ejected An inflow opening is formed on the part side, and an outflow opening is formed on the side opposite to the gas ejection part. The outflow opening is formed on an extension line of the jetting direction of the gas jetted from the gas jetting portion. [Effect of invention]

According to the present invention, it is possible to provide a biomedical solution injector which can spray the medical solution into a body cavity in finer granules.

[Preferred form for carrying out the invention]

Hereinafter, embodiments of the biological drug solution injection device of the present invention will be described with reference to the drawings. In addition, the embodiment described below is merely an example for helping the understanding of the present invention, and does not limit the present invention. That is, the shape, size, arrangement, etc. of the members described below can of course be changed and improved without departing from the gist of the present invention, and the present invention naturally includes the equivalents thereof. In addition, in all drawings, the same code|symbol is attached|subjected to the same component, and the repeated description is abbreviate|omitted suitably. Also, in the following, one side (the side away from the operator) of the expelling liquid medicine in the biological liquid medicine liquid injection device is designated as the front side or the distal end side, and the opposite side is designated as the rear side or the proximal end side, respectively. referred to as the distal end side and the proximal end side.

<Outline of the present invention> First, the outline of the present invention will be described mainly with reference to FIGS. 1 to 3 . FIG. 1 is a perspective view showing a living tissue adhesive coating tool 1 and its peripheral equipment according to the present embodiment. FIG. 2 is an enlarged perspective view showing the head 12 located at the front end of the nozzle X of FIG. 1 , and FIG. 3 is a cross-sectional view showing the front end of the nozzle X in a vertical cross-section through the central axis of the ejection pipe 13 and the gas ejection portion 12f.

As shown in FIG. 1 , the biomedical solution injection tool (living tissue adhesive application tool 1 ) includes a main body portion 2 and a nozzle X extending from the main body portion 2 . The nozzle X is provided with: a pipe-shaped chemical liquid ejection portion (the ejection pipe 13 ) that is provided at the front end portion (the head portion 12 ) of the nozzle X and ejects the chemical liquid 10 in the internal space; The chemical solution 10 ejected by the ejection tube 13 is a gas ejection part 12f for spraying the gas (supply gas G) to spray the chemical solution 10 in the form of a mist. In the peripheral wall 13a of the ejection pipe 13, an inflow opening (slit 13b) is formed on the gas ejection portion 12f side, and an outflow opening (slit 13c) is formed on the opposite side to the gas ejection portion 12f. The gas ejection portion 12f ejects the supply gas G in a direction intersecting with the ejection direction of the chemical liquid 10 ejected from the ejection pipe 13 . The slits 13b and 13c are characterized in that they are formed on the extension line of the injection direction of the supply gas G injected from the gas injection part 12f.

In the ejection pipe 13 of the present embodiment, the inflow opening into which the supply gas G flows is set as the slit 13b, and the outflow opening into which the supply gas G flows out is set as the slit 13c, but the present invention does not It is not limited to these structures.

That is, the "inflow opening" and the "outflow opening" in the ejection tube 13 only need to allow the supply gas G to pass into the liquid medicine ejection section (ejection tube 13 ) to cut off the liquid medicine 10 . Therefore, the "inflow opening" and the "outflow opening" are not limited to the long slits 13b and 13c, and may be circular holes or lattice-shaped holes. In addition, a plurality of these may be provided, and a mesh-shaped member may be joined to the distal end portion of the chemical-solution ejection portion (the ejection tube 13 ) and formed.

In the following, a description will be given of a configuration in which the ejection pipe 13 extends parallel to the extending direction of the nozzle X, and the gas ejection portion 12f extends in a direction intersecting the extending direction of the ejection pipe 13 to eject the supply gas G to the outlet from the ejection pipe 12f. 13 Spit Potion 10. However, it is not limited to these configurations, and the opposite configuration is also possible (that is, the gas ejection portion 12f extends parallel to the extending direction of the nozzle X, and the ejection pipe 13 extends in a direction intersecting the extending direction of the gas ejection portion 12f. the composition of the extension).

According to the above-mentioned configuration, the supply gas G can be supplied to the chemical liquid ejection portion (the ejection tube 13 ) so as to pass through the inflow opening (slit 13b ) and the outflow opening (slit 13c ) formed in the chemical liquid ejection portion (discharge tube 13 ). The chemical liquid 10 of the ejection tube 13 is finer and sprayed.

＜About the overall structure＞ Referring mainly to FIGS. 1 and 2 , a description will be given of the overall configuration of the living tissue adhesive application tool 1 and its peripheral equipment as the living body chemical liquid injection tool of the present invention. The apparatus for injecting the biological medicinal solution (the apparatus for applying the biological tissue adhesive agent 1 ) of the present invention is a means for injecting (applying/spraying) the medicinal solution into the body. The medicinal solution 10 (refer to FIG. 3 ) to be sprayed by the biomedical solution spraying device of the present invention may be one type, and may be the same as the medicinal solution 10 sprayed by the living tissue adhesive coating device 1 of the present embodiment two or more. The living tissue adhesive coating tool 1 has a function of spraying/mixing a plurality of chemical liquids 10 to be described later at the discharge place, and applying the adhesive to organs and the like in the living body as an adhesive.

The living tissue adhesive coating tool 1 includes a main body portion 2 having a space 2s inside, and a nozzle X that communicates with the space 2s of the main body portion 2 and extends to the distal end side. The nozzle X includes an extension portion 11 that communicates with the space 2s inside the main body portion 2 and is provided to extend from the front end side of the main body portion 2 , and a head portion 12 to be described later attached to the front end of the extension portion 11 .

A syringe attachment port 2d is provided at the proximal end portion of the main body portion 2 so as to protrude toward the proximal end side. The medicinal solution 10 is supplied to the ejection tube 13 via the main body portion 2 from the syringe 17 and the plunger 7 attached to the syringe attachment port 2d. In addition, the supply gas G (see FIG. 3 ) is filled in the main body portion 2 via the gas injection portion 2g. The gas supply gas G filled in the main body portion 2 is supplied to the gas ejection portion 12f. The main body 2 is provided with a gas injection part 2g for injecting the supply gas G (see FIG. 3 ) into the space 2s inside the body 2 . Specifically, the gas injection portion 2g is formed at the protrusion of the portion formed on the main body portion 2 which protrudes obliquely upward and rearward (proximal end side).

The gas ejection portion 12f, which will be described in detail later, ejects the supply gas G filled in the space 2s inside the main body portion 2 from the gas ejection portion 2g, and ejects it from the ejection pipe 13. The medicinal liquid 10 is sprayed and mixed into a mist.

The air supply pipe 31 for introducing the air supply gas G for spraying the chemical solution 10 to the main body portion 2 is connected to the living tissue adhesive coating tool 1 . The air supply pipe 31 is connected to the regulator 30 that adjusts the amount of the air supply gas G, and is connected to the main body 2 via the air filter 9 .

Specifically, the air supply pipe 31 is connected to the regulator 30 by the connector 31a provided on the proximal end side, and is connected to the connection port 9a of the air filter 9 by the connector 31b provided on the front end side. Dust is removed from the supply gas G and foreign bacteria are removed by passing the supply gas G supplied from the regulator 30 through the air filter 9 . The air supply gas G is introduced into and filled into the space 2s inside the main body portion 2 from the regulator 30 via the air supply pipe 31, the air filter 9, and the gas injection portion 2g.

In addition, the main body 2 is mounted with an inside of the main body 2 (more specifically, a tube (not shown) which is located in the main body 2 and connected to the discharge tube 13 ) for introducing different medicinal solutions into the main body 2 through the syringe attachment port 2d. In addition, two plungers 7 and two syringes 17 are each provided. Specifically, at the end portions on both sides of the rear surface of the main body portion 2, two portions protrude rearward, and a syringe attachment port 2d serving as a liquid medicine injection portion is formed at the rear end of these portions. The syringes 17 are connected to the two syringe attachment ports 2d, respectively. The plunger 7 is pushed into the syringes 17, whereby the medicinal solution 10 filled in the two syringes 17 is supplied to the ejection tube 13 through a tube (not shown) in the main body 2 through the syringe attachment port 2d.

Furthermore, the living tissue adhesive coating tool 1 includes a plunger holder 8 for pressing the two plungers 7 against the syringe 17 at the same time. The plunger holder 8 is formed in a size that can abut against the proximal end sides of the two plungers 7 .

The extension part 11 with which the nozzle X is provided is for securing the length for disposing the head part 12 attached to the front end of the extension part 11 in the body cavity. For example, the biological tissue adhesive coating tool 1 is used when performing surgery using a thoracoscope. For example, when an EAS (endoscope assisted surgery) operation is performed by inserting a trocar (not shown), it is necessary to apply the medicinal solution 10 to the place after the trocar is inserted. In this case, since the nozzle X is provided with the extension portion 11, the nozzle X can be lengthened in the axial direction to extend the position where the chemical liquid 10 is sprayed, that is, the position where the head 12 can reach according to the application position of the chemical liquid 10. .

＜About the structure around the head＞ Next, the head 12 and the configuration around the head 12 will be described mainly with reference to FIG. 4 in addition to FIGS. 1 to 3 . FIG. 4 is a front view of the head 12 . As shown in FIGS. 2 and 3 , the head 12 of the present embodiment includes a head body 12 b , two tubular discharge pipes 13 , and is located in the vicinity of the discharge pipes 13 for spraying and supplying the chemical liquid 10 sprayed from the discharge pipes 13 . The two gas ejection portions 12f of the gas G are provided.

A fitting portion 12h to be fitted to the front end of the extension portion 11 is formed at the rear end portion of the head body 12b. The fitting portion 12h has an outer surface having a diameter smaller than that of the other parts in the head body 12b, and the outer surface is fitted in a state opposed to the inner surface of the extension portion 11 .

[spray tube] The ejection tube 13 extends from the head body 12b toward the distal end. The chemical liquid 10 is sprayed in the form of a mist by the supply gas G sprayed from the gas spraying part 12f. To the proximal end portion of the ejection tube 13, a distal end portion of a medical solution flow tube not shown is connected, and the medical solution flow tube communicates with the syringe attachment port 2d. Two kinds of chemical liquids to be mixed are ejected from the two ejection pipes 13 .

In the present embodiment, one side of the ejection tube 13 ejects a medicinal liquid containing fibrinogen or the like. The other side of the ejection tube 13 circulates a medicinal solution containing thrombin and the like and acting on fibrinogen and the like to function as an adhesive.

The chemical liquid ejection portion (the ejection tube 13 ) is formed at a position closer to the end side (the base end side on the head body 12b side) than the inflow opening portion (slit 13b ) and the outflow opening portion (slit 13c ) There is a surrounding portion 13d formed around the entire circumference. That is, in the discharge pipe 13 of the present embodiment, there is a portion (a portion with a circular cross-section) that does not intersect the slits 13b and 13c in the circumferential direction.

According to the above-described configuration, by forming the surrounding portion 13d, it is possible to suppress the decrease in rigidity of the chemical liquid ejection portion (discharge tube 13) due to the inflow opening (slit 13b) and the outflow opening (slit 13c).

As shown in FIG. 4 , the opening width W2 on the outer peripheral side of the inflow opening (the slit 13 b ) is wider than the opening width W1 on the inner peripheral side. Here, the "width" refers to the length in the direction orthogonal to the jetting direction of the gas jetting portion 12f when the head portion 12 of the nozzle X is viewed from the axial direction (the direction shown in FIG. 4 ). The outer peripheral side and the inner peripheral side of the inflow opening are synonymous with the outer peripheral side and the inner peripheral side of the discharge pipe 13 .

According to the above configuration, since the opening width W2 on the outer peripheral side of the inflow opening (slit 13b ) is wider than the opening width W1 on the inner peripheral side, the supply gas G can be widely received into the discharge pipe 13, and the retraction can be accelerated. The flow rate of the supply gas G into the inside of the spouting pipe 13 . Therefore, the chemical liquid 10 to be supplied to the inside of the ejection tube 13 is sheared by the supply gas G and is easily fine-grained.

As shown in FIG. 4 , the opening width W2 on the outer peripheral side of the inflow opening portion (slit 13 b ) is wider than the flow channel diameter D of the gas ejection portion 12 f. When the supply gas G ejected from the gas ejection portion 12f is discharged from the gas ejection portion 12f, the spray area of the supply gas G widens as it moves away from the gas ejection portion 12f.

According to the above configuration, since the opening width W2 of the slit 13b is wider than the flow channel diameter D of the gas ejection portion 12f, the supply gas G discharged and diffused from the gas ejection portion 12f can be widely taken in from the slit 13b. Conversely, the flow channel diameter D of the gas ejection portion 12f is formed to be narrower than the opening width W2 on the outer peripheral side of the slit 13b. In this way, by narrowing the flow channel diameter D, the flow channel area of the gas ejection portion 12f can be reduced, and the supply gas supplied from the gas ejection portion 12f can be reduced due to the pressure loss caused by contact with the wall surface of the gas ejection portion 12f. G wind pressure, and increase the wind speed. Therefore, it is possible to suppress the occurrence of deviation in the spray area of the chemical solution 10 .

The opening width W1 on the inner peripheral side of the inflow opening portion (slit 13 b ) is narrower than the flow channel diameter D of the gas ejection portion 12 f. According to the above configuration, the flow rate of the supply gas G is increased, the supply gas G is taken into the inside of the ejection tube 13 , and the chemical solution 10 supplied to the inside of the ejection tube 13 is sheared to be easily fine-grained.

The opening width W4 on the outer peripheral side of the outflow opening (the slit 13 c ) is wider than the opening width W3 on the inner peripheral side. The chemical solution 10 flowing into the ejection tube 13 can be ejected to the outside by the outflow opening (the slit 13 c ) having the opening width W4 on the outer peripheral side wider than the opening width W3 on the inner peripheral side, thereby ejecting the fine-grained chemical solution.

Conversely, the opening width W3 on the inner peripheral side of the slit 13c is narrower than the opening width W4 on the outer peripheral side of the slit 13b. With this configuration, the chemical solution 10 before atomization can be suppressed from dripping downward through the opening width W3.

At least one of the inflow opening (slit 13 b ) and the outflow opening (slit 13 c ) is formed in a slit shape, and is formed long in the extending direction of the chemical liquid ejection portion (discharge tube 13 ). In addition, in the present embodiment, as described above, both the inflow opening and the outflow opening are formed in a slit shape. However, only one may be a circular hole or a rectangular hole, rather than a slit shape.

As described above, if at least one of the inflow opening portion and the outflow opening portion is the slits 13b and 13c extending parallel to the extending direction of the ejection tube 13 serving as the flow path direction of the medicinal solution 10, the following viewpoints More preferably, even if it is the chemical liquid 10 with a fast flow rate, the chemical liquid 10 can be cut off in a wide range in the direction of the flow channel by passing the supply gas G through the slits 13b and 13c.

As shown in FIG. 2 , when the outer surface of the ejection tube 13 is viewed in the radial direction, the bottoms, which are edge surfaces on the proximal end side of the slits 13b and 13c, are formed in a circular arc shape. That is, the slits 13b and 13c have arcuate edge portions. By forming the slits 13b in this way, the supply gas G injected from the gas injection part 12f can be easily received into the injection pipe 13 .

In addition, the bottoms of the slits 13b and 13c are formed so as to be widely opened toward the outer peripheral side. By configuring the slits 13b and 13c in this way, the supply gas G is more likely to flow in even in the axial direction of the discharge pipe 13, and it is easy to expand when it flows out.

As shown in FIG. 3 , the chemical liquid ejection portion (the ejection tube 13 ) extends and protrudes toward the distal end side of the gas ejection portion 12 f. The ejection opening 12m of the gas ejection portion 12f is formed so as to protrude toward the front end side of the ejection pipe 13 as the ejection opening 12m of the gas ejection portion 12f is inclined with respect to an imaginary plane orthogonal to the extending direction of the ejection pipe 13 .

In other words, the surface on which the ejection openings 12m are formed (in this embodiment, the orthogonal surface 12n formed so as to be orthogonal to the ejection direction of the supply gas G) is an imaginary plane orthogonal to the extending direction of the ejection pipe 13 . It is formed obliquely so as to protrude toward the front end side of the discharge pipe 13 as it moves away from the discharge pipe 13 in the radial direction. In this way, by forming the orthogonal surface 12n inclined with respect to the virtual plane, the upper end of the discharge opening 12m is left and right close to the discharge pipe 13 by a length equal to the diameter of the front end opening of the discharge pipe 13 .

According to the above configuration, since the discharge opening 12m of the gas discharge portion 12f is formed to protrude toward the front end side of the discharge pipe 13, the flow velocity of the supply gas G until it reaches the discharge pipe 13 is easily maintained high.

In addition, although the discharge pipe 13 of this embodiment and the chemical|medical solution flow pipe which is not shown in figure passing through the main body part 2 are separate entities, this invention is not limited to these structures, It can also be formed integrally. Further, as long as the chemical solution 10 can be sprayed in a direction intersecting the axial direction of the nozzle X, the extending direction of the ejection tube 13 as the ejection direction of the chemical solution 10 does not need to be parallel to the axial direction of the nozzle X.

[Gas ejection part] The gas ejection portion 12f is a portion where the supply gas G filled in the space 2s inside the body portion 2 from the gas ejection portion 2g is ejected from the front end portion of the head portion 12 . The gas ejection portion 12f of the present embodiment has two through holes extending toward the ejection portion of the chemical liquid 10 ejected by the two ejection pipes 13 respectively. Specifically, the gas ejection portion 12f extends obliquely downward toward the distal end side so as to intersect the axial center direction of the nozzle X (and the ejection tube 13).

Since the ejection pipe 13 and the gas ejection portion 12f each extend in such a direction, by rotating the living tissue adhesive coating tool 1 around the axis of the nozzle X, the ejection direction of the supply gas G can be oriented. The spray direction of the chemical solution 10 can be adjusted. Hereinafter, the ejection direction refers to a vector toward the distal end side with reference to the gas ejection portion 12f.

In addition, the gas ejection portion 12f may extend parallel to the extending direction of the nozzle X as described above, without requiring a configuration in which the spraying direction of the chemical solution 10 is adjusted by the rotation of the living tissue adhesive coating tool 1 . , and the ejection pipe 13 extends in a direction intersecting with the extending direction of the gas ejection portion 12f.

As shown in FIG. 3, the discharge opening 12m of the gas discharge part 12f is formed in the plane (orthogonal plane 12n) orthogonal to the spray direction of the supply gas G. According to the above configuration, the supply gas G can be easily sprayed from the ejection opening 12m at the same timing symmetrically with respect to the central axis of the gas ejection portion 12f, and the chemical liquid 10 sheared and induced by the supply gas G can be easily sprayed uniformly. .

The opening area of the gas ejection portion 12f is smaller than the opening area of the chemical liquid ejection portion (the ejection pipe 13). The "opening area" refers to the area of the opening on the plane in which the opening is formed. That is, the opening area of the gas ejection portion 12f is the area of the opening on the orthogonal surface 12n extending in the direction orthogonal to the ejection direction of the supply gas G. The opening area of the ejection tube 13 is the area of the opening on the front end surface of the ejection tube 13 (the openings other than the slit 13b and the slit 13c are the circular portion shown in FIG. 4 in this embodiment).

According to the above configuration, since the opening area of the gas ejection portion 12f is smaller than the opening area of the chemical solution ejection portion (the ejection pipe 13 ), the pressure loss (energy loss) of the supply gas G can be increased, the wind force can be reduced, and the wind speed can be increased. By injecting and supplying the supply gas G to the chemical liquid 10 in this way, the chemical liquid 10 can be promoted to be in the form of a fine mist.

The diameter of the flow passage of the gas ejection portion 12f is 0.3 mm or more and 0.6 mm or less. In this way, when the diameter of the flow path of the gas ejection portion 12f is 0.3 mm or more and 0.6 mm or less, the ejection amount of the supply gas G can be ensured, and the flow rate can be increased, so that the particles of the chemical solution 10 to which the supply gas G has been ejected can be Thinning.

[eaves] The head 12 is further provided with the eaves part 12i at the site|part on the opposite side to the site|part where the ejection pipe 13 is provided with the gas ejection part 12f at the front-end|tip part. The eave portion 12i is provided so as to cover the gas ejection portion 12f and the tip of the ejection tube 13, and is formed to protrude farther than the tip of the ejection tube 13 based on the ejection direction of the chemical solution 10. In particular, the eaves part 12i is formed in a gentle pointed shape. Specifically, the eaves portion 12i is formed such that the center portion in the width direction (in the present embodiment, the direction parallel to the direction in which the two ejection tubes 13 are arranged) protrudes farthest to the distal end side, and as the width direction two The amount of protrusion from the head body 12b becomes smaller. More specifically, the eave portion 12i protrudes from the head body 12b by a length twice or more of the protruding length from the head body 12b of the discharge pipe 13 .

The eaves portion 12i thus formed functions as a wall between the gas ejection portion 12f and the ejection pipe 13 and the surrounding environment. Therefore, the eaves part 12i can suppress the influence from the surrounding environment of the supply gas G ejected from the gas ejection part 12f, and can maintain the rectification|straightening property of the spray of the chemical|medical solution 10. Moreover, according to the eave portion 12i, clogging of the gas ejection portion 12f or the ejection tube 13 due to bodily fluid or the like adhering to the ejection tube 13 for ejecting the medicinal solution 10 and the organ etc. can be suppressed. Furthermore, by forming the eave portion 12i into a pointed shape, it is easy to insert the nozzle X from the head portion 12 into the trocar (not shown).

＜About spray results＞ Next, mainly referring to FIG. 5 and FIG. 6 , the results of spraying of the chemical solution 10 by the living tissue adhesive coating tool 1 of the present embodiment (Example) and the living tissue adhesive coating by the conventional not shown The spray result (comparative example) of the chemical|medical solution 10 of a tool is demonstrated. FIG. 5 is a graph showing the air force per air pressure of the supply gas G with respect to the comparative example and the example, and FIG. 6 is a graph showing the particle size of the spray chemical liquid with respect to the comparative example and the example.

The comparative example shows a living tissue adhesive application tool not shown in which a slit is not formed in the ejection tube and the gas ejection portion does not protrude from the head body 12b. The wind force shown in FIG. 5 is a load measured when the supply gas G is vertically ejected from the gas ejection portion 12f to a measuring instrument disposed at a position separated from the gas ejection portion 12f by 5 cm. The detailed numerical values shown in the graph of FIG. 5 are shown in Table 1.

[Table 1] Air pressure (MPa) Wind (g weight) Comparative example Example 0.13 2.40 1.30 0.12 2.21 1.15 0.11 1.99 1.05 0.10 1.73 0.95 0.09 1.55 0.87 0.08 1.32 0.78 0.07 1.10 0.65 0.06 0.95 0.56 0.05 0.76 0.45

As shown in FIG. 5 and Table 1, in the Example of the living tissue adhesive agent coating tool 1, the wind force can be suppressed to about 0.5 times to about 0.6 times with respect to the comparative example. Furthermore, in the spray test shown in FIG. 6 , in the example, compared with the comparative example, even if the air pressure of the supply gas G sprayed from the gas spraying part 12f is as low as 0.07 MPa, the fine-grained chemical solution can be sprayed 10 Apply to the target surface.

<Variation> In the head 12 in the above-described embodiment, the slit 13b and the slit 13c are formed with the same length in the axial direction of the discharge pipe 13, but the present invention is not limited to this configuration. Next, the head 22 of the modification example will be described mainly with reference to FIG. 7 . FIG. 7 is a view showing the head 22 according to the modification, and is a cross-sectional view of the front end portion of the nozzle X taken along the vertical cross-section of the central axis of the ejection pipe 23 and the gas ejection portion 12f. The slit 23c serving as the outflow opening in this example is formed to have a shorter length than the slit 13c serving as the inflow opening, and the slit 23c is provided on the extension line connecting the lower end of the gas ejection portion 12f and the base end of the slit 13c. base end. That is, the slit 23c is formed on the extension line of the supply gas G injected from the gas injection part 12f and passed through the slit 13c. By forming the ejection tube 23 in this way, it is possible to increase the flow rate of the chemical liquid 10 sheared by the supply gas G passing through the slit 13b to flow out from the slit 23c relative to the ratio of the uncut chemical liquid 10 flowing out of the slit 23c. Proportion. According to such a configuration, droplets of the chemical solution 10 before atomization can be suppressed from dripping.

In addition, the living tissue adhesive coating tool 1 of the present embodiment is provided with a chemical liquid flow channel formed in each of the two ejection tubes 13 . However, the biomedical solution injection device of the present invention is not limited to such a configuration, and may have more medical solution flow channels, or, conversely, one may be sufficient. Similarly, the number of gas ejection parts 12f is not limited to two, and may be provided more, and conversely, one may be sufficient.

In addition, in the above-described embodiment, the configuration in which the supply gas G is sprayed in parallel from the two gas ejection portions 12f has been described. Even with this configuration, since the diameter of the ejection tube 13 is small and the cross-sectional area of the chemical solution 10 passing through the ejection tube 13 is sufficiently small, the two kinds of the chemical solution 10 can be appropriately mixed. However, the present invention is not limited to these configurations, and may be a configuration in which the two gas ejection portions 12f extend in directions intersecting with each other in order to promote the mixing of the two chemical solutions 10 such that the two gas ejection portions extend from the two gas ejection portions The supply gas G injected by 12f intersects at the point where it is injected. Even in this case, it is only necessary to have the ejection pipe 13 and the inflow opening and the outflow opening formed in the ejection pipe 13 at the point where the supply gas is ejected.

The above-described embodiment includes the following technical ideas. (1) A biomedical liquid spraying appliance is characterized in that it has: the body part; and a nozzle extending from the body portion, This nozzle has: a tubular liquid medicine ejection part, which is provided at the front end of the nozzle and ejects the liquid medicine in the inner space; and The gas ejection portion is located in the vicinity of the chemical liquid ejection portion, and sprays the chemical liquid in a mist form by injecting gas to the chemical liquid ejected from the chemical liquid ejection portion, In the peripheral wall of the chemical solution ejection portion, an inflow opening portion is formed on the gas ejection portion side, and an outflow opening portion is formed on the side opposite to the gas ejection portion side, The gas ejection portion ejects the gas in a direction intersecting with the ejection direction of the chemical liquid ejected from the chemical liquid ejection portion, The said inflow opening part and the said outflow opening part are formed in the extension line of the injection direction of the said gas injected by the said gas injection part. (2) Such as the biological liquid injection device of (1), wherein, In the chemical liquid ejection portion, a surrounding portion formed around the entire circumference is formed at a position closer to the end side than the inflow opening portion and the outflow opening portion. (3) Such as (1) or (2) the biological liquid injection device, wherein, The opening width on the outer peripheral side of the inflow opening is wider than the opening width on the inner peripheral side. (4) Such as the biological liquid injection device of (3), wherein, The width of the opening on the outer peripheral side of the inflow opening is wider than the diameter of the flow passage of the gas ejection portion. (5) Such as (3) or (4) object liquid injection device, wherein, The opening width on the inner peripheral side of the inflow opening is narrower than the diameter of the flow passage of the gas ejection portion. (6) As in any one of (1) to (5), the biomedical liquid injection device, wherein, The opening width on the outer peripheral side of the outflow opening is wider than the opening width on the inner peripheral side. (7) As described in any one of (1) to (6), the biomedical liquid injection device, wherein, At least one of the said inflow opening part and the said outflow opening part is formed in a slit shape, and is formed long in the extending direction of the said chemical|medical solution ejection part. (8) As in any one of (1) to (7), the biomedical liquid injection device, wherein, The opening area of the gas ejection portion is smaller than the opening area of the chemical liquid ejection portion. (9) As in any one of (1) to (8), the biomedical liquid injection device, wherein, The liquid medicine ejection portion extends and protrudes farther to the distal end side than the gas ejection portion, The ejection opening of the gas ejection portion is formed inclined with respect to an imaginary plane orthogonal to the extending direction of the chemical solution ejection portion so as to protrude toward the front end side of the chemical solution ejection portion as it moves away from the chemical solution ejection portion. (10) Such as the biological liquid injection device of (9), wherein, The said ejection opening is formed in the surface orthogonal to the ejection direction of the said gas. (11) As in any one of (1) to (10), the biomedical liquid injection device, wherein, The diameter of the flow passage of the gas ejection portion is 0.3 mm or more and 0.6 mm or less. [Industrial Availability]

According to the present invention, it is possible to provide a biomedical solution injector which can spray the medical solution into a body cavity in finer granules.

1: Living tissue adhesive coating equipment (biological liquid injection equipment) 2: Main body 2d: Syringe mounting port 2g: Gas injection part 2s: space 7: Plunger 8: Plunger holder 9: Air filter 9a: connector 10: liquid medicine 11: Extensions 12: Head (front end) 12b: head body 12f: Gas ejection part 12h: Fitting part 12i: Eaves 12m: ejection opening 12n: Orthogonal plane 13: Ejection tube (medicine ejection part) 13a: Peripheral Wall 13b: Slit (inflow opening) 13c: Slit (outflow opening) 13d: Surround 17: Syringe 22: Head (front end) 23: Spit tube 23c: slit (outflow opening) 30: Regulator 31: Air supply pipe 31a, 31b: Connectors G: Supply gas (gas) X: Nozzle

Fig. 1 is a perspective view showing the living tissue adhesive coating tool and its peripheral equipment according to the present embodiment. [ Fig. 2 ] is an enlarged perspective view showing a head located at the front end portion of the nozzle of Fig. 1 . 3 is a cross-sectional view showing a front end portion of the nozzle in a vertical cross-section passing through the central axis of the ejection pipe and the gas ejection portion. [Fig. 4] A front view of the head. [ Fig. 5] Fig. 5 is a graph showing the wind power for each air pressure of the supply gas with respect to the comparative example and the example. [ Fig. 6] Fig. 6 is a graph showing the particle size of the sprayed chemical solutions in Comparative Examples and Examples. [ Fig. 7] Fig. 7 is a view showing a head portion of a modified example, and is a cross-sectional view of the tip portion of the nozzle taken along the vertical cross-section of the central axis of the ejection pipe and the gas ejection portion.

1: Living tissue adhesive coating equipment (biological liquid injection equipment)

2: Main body

2d: Syringe mounting port

2g: Gas injection part

2s: space

7: Plunger

8: Plunger holder

9: Air filter

9a: connector

11: Extensions

12: Head (front end)

17: Syringe

30: Regulator

31: Air supply pipe

31a, 31b: Connectors

X: Nozzle

Claims (11)

A biomedical liquid spraying appliance is characterized in that it has: the body part; and a nozzle extending from the body portion, This nozzle has: A tubular liquid medicine ejection part is provided at the front end of the nozzle and ejects the liquid medicine in its inner space; and The gas ejection part is located in the vicinity of the chemical liquid ejection part, and sprays the chemical liquid sprayed from the chemical liquid ejection part with gas to spray the chemical liquid in the form of a mist, In the peripheral wall of the chemical liquid ejection portion, an inflow opening portion is formed on the gas ejection portion side, and an outflow opening portion is formed on the opposite side to the gas ejection portion side, The gas ejection portion ejects the gas in a direction intersecting with the ejection direction of the chemical liquid ejected from the chemical liquid ejection portion, The inflow opening portion and the outflow opening portion are formed on an extension of the injection direction of the gas injected by the gas injection portion. As claimed in claim 1, the biological liquid injection device, wherein, In the chemical liquid discharge portion, a surrounding portion formed around the entire circumference is formed at a position closer to the end side than the inflow opening portion and the outflow opening portion. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, The opening width on the outer peripheral side of the inflow opening is wider than the opening width on the inner peripheral side. As claimed in claim 3, the biological liquid injection device, wherein, The opening width on the outer peripheral side of the inflow opening portion is wider than the flow channel diameter of the gas ejection portion. As claimed in claim 3, the biological liquid injection device, wherein, The opening width on the inner peripheral side of the inflow opening portion is narrower than the flow passage diameter of the gas ejection portion. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, The opening width on the outer peripheral side of the outflow opening is wider than the opening width on the inner peripheral side. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, At least one of the inflow opening portion or the outflow opening portion is formed in a slit shape and is formed long in the extending direction of the chemical liquid ejection portion. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, The opening area of the gas ejection portion is smaller than the opening area of the chemical liquid ejection portion. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, The liquid medicine ejection portion extends and protrudes farther to the distal side than the gas ejection portion, The ejection opening of the gas ejection portion is formed obliquely with respect to an imaginary plane orthogonal to the extending direction of the chemical liquid ejection portion so as to protrude toward the front end side of the chemical liquid ejection portion as it moves away from the chemical liquid ejection portion. As claimed in claim 9, the biological liquid injection device, wherein, The ejection opening is formed on a plane orthogonal to the ejection direction of the gas. As claimed in claim 1 or claim 2, the biological liquid injection device, wherein, The diameter of the flow passage of the gas ejection portion is 0.3 mm or more and 0.6 mm or less.

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