CN217489464U

CN217489464U - Atomizing catheter capable of targeting drug delivery

Info

Publication number: CN217489464U
Application number: CN202123140053.8U
Authority: CN
Inventors: 徐宏; 王茂强; 徐鹏威; 关玉
Original assignee: Hangzhou Kunbo Biotechnology Co Ltd
Current assignee: Hangzhou Kunbo Biotechnology Co Ltd
Priority date: 2021-05-26
Filing date: 2021-12-13
Publication date: 2022-09-27
Anticipated expiration: 2031-12-13
Also published as: CN217489465U; CN114129837A; CN216934313U; CN218739765U; CN114129835A; CN217489463U; CN217162788U; CN216934312U; CN114129834A; CN115177823A; CN115177822A; CN217489461U; CN114129836A

Abstract

The application discloses an atomization catheter capable of achieving targeted drug delivery, which comprises a catheter body, wherein one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged inside the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then is output; the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, the fluid is atomized through the atomizing chamber, the atomizing chamber is provided with a plurality of nozzles for atomized fluid, and at least two nozzles are different in direction. The utility model provides an atomizing pipe diameter is thinner, can go deep into the unable lung section that gets into of endoscope and carry out accurate atomizing and dose, and through targeting atomizing and dose, the drug effect is used in patient affected part more fast more accurately, avoids the liquid medicine to remain in oral cavity, nasal cavity.

Description

Atomizing catheter capable of targeting drug delivery

Technical Field

The present application relates to the field of medical devices, and in particular to a targetable drug delivery nebulizing catheter that can be used for the treatment of bronchial diseases.

Background

When the treatment is performed under a clinical endoscope, an atomization administration mode is usually needed to be matched, so that the injected medicine liquid can be uniformly distributed, the uniformity of the combination of related tissues (such as bronchial mucosa and gastrointestinal tract mucosa) and medicines is improved, and the impact injury possibly caused by the traditional direct injection to the tissues is reduced to the maximum extent.

The existing nebulizers are used for administering drugs by inhalation, and liquid drugs are decomposed into aerosol of fine particles or droplets, so that the patients using the drugs can inhale and absorb the drug more efficiently.

The existing atomization equipment has large drug delivery end volume, the atomization effect needs to be improved, targeting drug delivery is difficult to be carried out on small-area lesions, and the treatment effect needs to be further improved.

SUMMERY OF THE UTILITY MODEL

The application provides an atomizing pipe that can intervene intrabronchial and release treatment material, atomization effect is better, and the position of dosing is more accurate, can carry out the target to the small-area focus and administer, further improves administration efficiency and treatment.

The application provides an atomization catheter capable of achieving targeted drug delivery, which comprises a catheter body, wherein one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged inside the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then is output;

the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, the fluid is atomized through the atomizing chamber, the atomizing chamber is provided with a plurality of nozzles for atomized fluid, and at least two nozzles are different in direction.

The application provides an atomizing pipe compares with traditional atomizer, and the body external diameter is littleer, and has certain flexibility, can get into the lung deep, and accurate dosing.

Depending on the nature of the therapeutic substance, the fluid itself may be in the liquid or gas phase, or a more complex mixing system, and atomization is intended to further disperse the fluid into smaller particles to facilitate absorption and uniform administration.

Because the atomizing chamber is provided with a plurality of nozzles facing to each other, when the focus of the lung is positioned on two sides of the bronchial wall, the liquid medicine can be accurately sprayed.

Several alternatives are provided below, but not as an additional limitation to the above general solution, but merely as a further addition or preference, each alternative being combinable individually for the above general solution or among several alternatives without technical or logical contradictions.

Optionally, with the extending direction of the tube body as a reference, the nozzle orientations are at least two of the following modes:

a. axially along the tube body and toward the distal side;

b. radially outward along the tube body;

c. tangential to the tube body.

With reference to the direction of extension of the tube, the nozzle may be oriented axially and distally, radially outwardly or tangentially, but may of course be slightly angled with respect to the above-mentioned directions.

Optionally, the atomization chamber has two nozzles facing in the axial direction of the tube body, namely a first nozzle facing in the axial direction of the tube body toward the distal side and a second nozzle facing in the radial direction of the tube body toward the outer side.

The direction mutually perpendicular of first spout and second spout, the fluid blowout through the spout of two directions after the atomizing, the direction of action is more accurate.

Optionally, the atomizing head comprises:

a plurality of atomization chambers, each having a plurality of fluid inlets and the orifice of atomized fluid;

a plurality of cannulas, each cannula is in inserted connection with a corresponding fluid channel in the tube body;

and each insertion pipe is connected to a corresponding fluid inlet in the atomizing chamber through a corresponding communication pipe.

The cross-sectional shapes of the cannulas and the communicating tubes are not strictly limited, such as circular, rectangular and the like, and the fluid state can be regulated and controlled through reasonable arrangement of the cross-sectional areas.

Optionally, the atomizing chamber includes a chamber wall, and an inner cavity is enclosed by the chamber wall, and each nozzle is opened on the chamber wall on the corresponding side.

The fluid in the atomizing chamber is mixed and atomized and then is sprayed out from the corresponding nozzle.

Optionally, the first nozzle opening is provided in the distal chamber wall, the second nozzle opening is provided in the outer chamber wall, and each fluid inlet is provided in the inner chamber wall. To accommodate the direction of fluid delivery.

Optionally, a flow divider is disposed in each atomization chamber, and one phase fluid is mixed with the other phase fluid after being acted by the flow divider.

The reposition of redundant personnel piece is favorable to improving atomization effect, and the fluid is through reposition of redundant personnel piece disturbance back, and it is better to mix atomization effect.

Optionally, the flow dividing element is a cover body with an opening on one side, the cover body is provided with a plurality of flow dividing holes, and one of the fluid inlets communicated with the atomizing chamber where the flow dividing element is located is in butt joint with the opening of the cover body.

The fluid enters the atomizing chamber and then enters the opening of the cover body, and is dispersed by the shunt holes of the cover body and then mixed and atomized with the other phase fluid.

Optionally, the cover body is of a hollow cubic structure, and except for the opening, a plurality of shunt holes are uniformly distributed on the side walls of the other five sides.

The side walls of each side of the cover body are fully utilized, the shunt holes are uniformly distributed, and fluid can flow out from the shunt holes on any side wall after entering the cover body.

Optionally, the atomizing chamber is divided into an inner chamber and an outer chamber by the cover body, wherein one phase fluid is introduced into the inner chamber, the other phase fluid is introduced into the outer chamber, and each nozzle is arranged on the wall of the outer chamber.

The flow dividing holes on the cover body are communicated with the inner chamber and the outer chamber, and the fluid in the inner chamber and the fluid in the outer chamber are mixed and then atomized and sprayed out.

The utility model provides an atomizing pipe atomization effect is better, and the position of dosing is more accurate, can go deep into the unable lung section that gets into of endoscope and carry out accurate atomizing and dose, and through targeting atomizing and dose, the drug effect is used in patient affected part more fast more accurately, avoids the liquid medicine to remain in oral cavity, nasal cavity.

Drawings

FIG. 1 is a schematic view of an embodiment of an atomization conduit;

FIG. 2 is a schematic view of the proximal fitting portion of FIG. 1;

FIG. 3 is an exploded view of the coupling portion of FIG. 2;

FIG. 4 is a schematic view of the internal structure of the pipe joint portion of FIG. 1;

FIG. 5 is a schematic view of the butt end of the pipe joint;

FIG. 6 is a schematic view of the butt end of the pipe body with the pipe joint;

FIG. 7 is a schematic view of the distal atomizing head of FIG. 1;

FIG. 8 is a schematic view of the atomizing head of FIG. 7 at another angle;

FIG. 9 is an exploded view of the atomizing head portion of FIG. 8;

FIG. 10 is a schematic view of the atomizing head of FIG. 9 at another angle;

FIG. 11 is an exploded view of the atomizing head of FIG. 10;

FIG. 12 is a schematic view of the atomizing head of FIG. 11 at another angle;

FIG. 13 is a perspective view of a flow splitter in the atomizing head;

FIG. 14 is a perspective view of an atomizing chamber in the atomizing head;

FIG. 15 is a front view of the atomizing head;

FIG. 16 is a sectional view taken along line A-A of FIG. 15;

fig. 17 is an enlarged view of a portion B in fig. 16.

The reference numerals in the figures are illustrated as follows:

100. a tube body; 110. an outer tube; 120. an inner tube; 130. a first channel; 140. a second channel;

200. a pipe joint; 210. a first joint; 220. a second joint; 230. a bus bar; 231. a first branch; 231', a first branch; 232. a second branch circuit; 232' and a second branch; 233. an output end; 234. a first branch pipe; 235. a second branch pipe;

400. an atomizing head; 410. a first cannula; 420. a second cannula; 430. a first communication pipe; 440. a second communicating pipe; 450. an atomization chamber; 451. an inner cavity; 452. an outer chamber wall; 453. a distal chamber wall; 454. an inner chamber wall; 460. a first nozzle; 470. a second nozzle; 480. a flow divider; 481. a cover body; 482. an opening; 483. and a shunt hole.

Detailed Description

The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.

It will be understood that when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present. When a component is referred to as being "disposed on" another component, it can be directly on the other component or intervening components may also be present.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this application belongs. The terminology used in the description of the present application herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the application. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.

In the existing oral or nasal cavity atomization administration mode, because the airway of a human body is very long, atomized particles are difficult to reach the far end of the lung, most of the atomized particles are deposited at the positions of the mouth, the nose and a main bronchus, and accurate administration cannot be carried out; in addition, the medicine cannot be deeply administrated into the air passage due to the size limitation of the apparatus, the treatment effect is not good, and improvement is needed.

Referring to fig. 1 to 17, in an embodiment of the present application, an atomization catheter is provided, which includes a tube 100, one end of the tube 100 is a proximal end, and the other end of the tube 100 is a distal end that can extend into a bronchus, a channel that can transport fluid from the proximal end to the distal end is formed inside the tube 100, an atomization head 400 is disposed at the distal end of the tube 100, and the fluid in the channel is atomized by the atomization head 400 and then output;

the atomizing head 400 has an atomizing chamber 450 therein for mixing a multiphase fluid, which is atomized through the atomizing chamber 450.

The atomizing catheter of this embodiment compares with traditional atomizer, and body 100 external diameter is littleer, and has certain flexibility, can get into the lung deep, and accurate dosing. The outer diameter, length, etc. of the tube 100 are not critical, but at least can extend into the bronchi to reach the lesion site, and preferred embodiments are provided below to achieve better results.

The tube body 100 may be made of metal or synthetic material, providing necessary mechanical properties and intervention safety, and may be in the form of a single tube, multiple tubes, or the like, according to the requirement of fluid delivery.

In order to facilitate the passage in the thinner bronchus, the outer diameter of the tube body 100 is generally not more than 1.2 mm-2.0 mm, for example, the outer diameter of the atomizing catheter is 1.8mm, and the tube body can reach the lung section which can not be reached by the endoscope, so that accurate atomizing administration can be realized.

Since the nebulizing catheter of the present application can extend into the bronchi, its length can be adapted accordingly, for example, the length of the tube 100 is 800 mm-1200 mm.

Multiphase fluids such as gases and liquids, and at least one of them may carry a therapeutic substance, determined in particular according to its physicochemical properties. The gas and the liquid can form tiny bubbles after mixing and intersection, and the bubbles carry liquid drops to be sprayed out, thereby integrally achieving the atomization effect.

The atomizing chamber 450 has at least a first fluid inlet, a second fluid inlet, and a nozzle for atomized fluid, although the first fluid inlet and the second fluid inlet may also meet in advance adjacent to the atomizing chamber 450, i.e. share a common fluid inlet.

To optimize the administration area, in one embodiment, the aerosolization chamber 450 has a plurality of orifices for aerosolized fluid and at least two of the orifices are oriented differently.

With reference to the direction of extension of the tube 100, the nozzle orifice may be oriented axially and distally, radially outwardly, tangentially, or at a slight angle to the directions described above.

The atomization chamber 450 is disposed in plural for atomization effect, and extends along the circumferential direction of the tube 100. The atomizing chambers 450 are radially disposed about the axis of the tubular body 100.

To facilitate interventional delivery, in one embodiment, the atomizing head 400 is a radially compressible structure having opposing compressed and released states. The compressible structure can adopt a mesh cage structure, a winding structure and the like.

The compressed atomizing head 400 is convenient to pass through the body under the compressed state, can be released as required after being adjacent to a focus, can finish administration once especially for the focus with a large area, does not need to adjust the position for many times, and compresses the atomizing head 400 when being required to be recovered, and is loaded on other pipe fittings to be withdrawn out of the body.

For multiple atomization chambers 450, the fluid may be delivered in a manifold, with the same fluid being branched off adjacent to the chambers 450 for distribution into each chamber 450, or in multiple parallel lines.

Of course, to facilitate the tubing arrangement, a manifold delivery is typically used between the inlet and atomizing conduits, and multiple tubes may be used in parallel as desired after the inlet into the tube 100.

The proximal end of the tube 100 is generally connected to a fluid-conveying infusion or storage device, and for ease of assembly, a fitting 200, such as a conventional luer fitting or the like, may be pre-secured to the proximal end of the tube 100, either by threading or snap-fitting to facilitate quick connection to an external line.

The pipe joint 200 may adopt a single interface or a plurality of parallel interfaces according to different fluids, when a plurality of interfaces are provided, the pipe joint 200 may adopt a three-way mode, a four-way mode, or the like, and a control valve may be configured for at least one interface, or certainly, the control valve may also adopt an external or detachable mode, and is connected to the pipe joint 200 only when necessary.

Referring to fig. 2 to 6, when a multiphase fluid is used, the pipe joint 200 includes:

a manifold 230 having a plurality of input ends and an output end 233, the output ends 233 communicating with respective fluid passageways within the tubular body 100;

a plurality of connectors, each of which communicates with one of the input terminals of the bus bar 230.

For example, when a two-phase fluid input is used, the confluence element 230 has two input ends, wherein one input end is communicated with the first connector 210 for accessing a gas phase or a liquid phase, and the other input end is communicated with the second connector 220 for accessing a liquid phase or a gas phase.

The two connections are connected to a fluid, one of which is in liquid phase and the other is in gas phase, for example, the first connection 210 is connected to gas phase and the second connection 220 is connected to liquid phase, and vice versa.

Inside the bus bar 230, a first branch 231 and a second branch 232 extend from the respective input ends, and the two branches converge and remain isolated from each other when they are adjacent to the output end 233. After being gathered together, the pipe body 100 can be more conveniently butted.

In one embodiment, a first leg 231 'and a second leg 232' are adjacent the output end 233 of the bus bar 230, with one leg being disposed about the periphery of the other leg.

For example, the second branches 232 'are distributed at the outer circumference of the first branches 231'. The distribution mode can be that the whole circle is wound on the periphery or the whole circle is distributed on the periphery at intervals.

The spacing is further advantageous for conveying the fluid conveyed by the second branch 232' in a multi-channel parallel manner inside the tubular body 100, for example at the output end 233 of the confluence member 230, where:

a first branch pipe 234, the first branch 231' is communicated with the first branch pipe 234,

a plurality of second branch pipes 235, the second branch pipes 232' are communicated with all the second branch pipes 235, and the plurality of second branch pipes 235 are arranged around the periphery of the first branch pipe 234 at intervals.

First branch pipe 234 and the plurality of second branch pipes 235 integrally form a plug structure, which facilitates quick assembly with pipe body 100.

Accordingly, the tube body 100 is a multi-lumen tube, and each lumen (i.e., fluid passage) in the multi-lumen tube communicates with a corresponding branch tube on the junction block 230. When the junction is mated, each branch pipe on the junction 230 can be inserted into the corresponding channel to achieve communication. After being inserted, the two parts can be relatively fixed in a bonding or interference fit mode.

The number of channels and the distribution of the interface portions in the multi-lumen tube should be matched with the branch tubes on the junction 230, and if necessary, matched fool-proof structures can be provided for positioning and plugging.

In the figure, 7 channels are provided in the multi-cavity tube, which can convey gas in the center and 6 liquid at the periphery.

Each channel in the barrel 100 extends distally and communicates with a corresponding fluid inlet on the atomizing head 400. In one embodiment, a central first channel 130 is included, and a plurality of second channels 140 are located at the periphery of the first channel 130.

To accommodate the design of the multiphase fluid, the atomizing head 400 in one embodiment includes:

a plurality of atomizing chambers 450, each atomizing chamber 450 having a plurality of fluid inlets and a spray orifice for the atomized fluid;

a plurality of cannulas, each cannula being in plug communication with a corresponding fluid channel in the body 100;

and each cannula is connected to a corresponding fluid inlet in the atomizing chamber 450 through a corresponding communication pipe.

One of the plurality of insertion tubes is a first insertion tube 410, and the rest are a plurality of second insertion tubes 420 distributed on the periphery of the first insertion tube 410.

The respective first cannulas 410 interface with the first channels 130 and the plurality of second cannulas 420 correspond to each of the second channels 140.

To facilitate the distribution of the fluid, in an embodiment, the first cannula 410 is connected to all nebulizing chambers 450 by first radially distributed communication tubes 430, and each second cannula 420 is connected to at least one nebulizing chamber 450 by a corresponding second communication tube 440.

In one embodiment, the plurality of nebulizing chambers 450 are distributed annularly, and each second cannula 420 accesses two circumferentially adjacent nebulizing chambers 450.

Each second cannula 420 is distributed between two circumferentially adjacent nebulizing chambers 450.

In one embodiment, for each second cannula 420, there are two second communicating tubes 440 respectively connected to the nebulizing chamber 450 on the corresponding side. The fluid distribution is more uniform and reasonable, the insertion pipes and the communicating pipes can avoid interference as much as possible, and the occupied space is saved.

In order to optimize the structure, in an embodiment, the first connection pipe 430 includes a plurality of branch pipes according to different radiation directions, for the same atomization chamber 450, one branch pipe connected to the atomization chamber 450 is provided, and two second connection pipes 440 connected to the atomization chamber 450 are provided and come from different second insertion pipes 420, and the two second connection pipes 440 are located at two sides of the branch pipe connected to the atomization chamber 450.

The plurality of branch pipes are preferably uniformly distributed radially in the circumferential direction. Furthermore, the atomizing head 400 has a rotational symmetric structure as a whole, and since there are 6 atomizing chambers 450 in the figure, the included angle between adjacent atomizing chambers 450 is 60 degrees, and the other parts are the same.

In order to further optimize the distribution, an included angle region is formed between two adjacent branch tubes, and each second insertion tube 420 of the plurality of second insertion tubes 420 is arranged in a corresponding included angle region.

For each second cannula 420, two second communicating tubes 440 are disposed in a substantially V-shape, extending from the second cannula 420 to the atomizing chamber 450 located at the radial outer side of the tubular body 100.

The communication position of the two second communication pipes 440 and the second cannula 420 is preferably on the side of the second cannula 420 facing the first cannula 410, i.e. the radially inner side of the tubular body 100.

The number of branches is the same as the number of second cannulae 420 and nebulizing chamber 450, so that a one-to-one match is achieved, 6 in the figure, and in other embodiments, 2-10, such as 4-8.

The direction that each communicating pipe inserts corresponding atomizer 450 can influence atomizing effect to a certain extent, in order in the embodiment, insert this atomizer 450 along same orientation to all communicating pipes of same atomizer 450.

In a preferred embodiment, all the communication pipes for the same nebulizing chamber 450 extend radially outwards of the tubular body 100 and join the respective nebulizing chamber 450.

I.e. radially to the tube 100, all fluid inlets of the nebulizing chamber 450 are inside. The structure is more compact.

All cannulae are on the proximal side of the nebulizing chamber 450 in the axial direction of the barrel 100. In the case of the atomizing head 400 as a whole, after each cannula is inserted into a channel in the tubular body 100, each communicating tube and the atomizing chamber 450 are located on the distal side of the exterior of the tubular body 100.

All the branch pipes and the communicating pipes are arranged approximately in a same plane and abut against the far end face of the pipe body 100.

For proper distribution of the drug delivery, in one embodiment, the aerosolizing chamber 450 is provided with two orifices oriented axially distally along the tubular body 100, a first orifice 460 and radially outwardly along the tubular body 100, a second orifice 470.

The atomizing chamber 450 includes chamber walls defining an interior 451, with orifices opening into the chamber walls on opposite sides, such as a first orifice 460 opening into a distal chamber wall 453, a second orifice 470 opening into an outer chamber wall 452, and fluid inlets opening into an inner chamber wall 454. The fluids of different phases are mixed in the inner cavity 451 and atomized and sprayed out.

In order to improve the mixing and atomizing effect, a flow divider 480 is disposed in the atomizing chamber 450, wherein one phase fluid is mixed with another phase fluid after passing through the flow divider 480.

In one embodiment, the flow divider 480 is a cover 481 with an opening 482 on one side, and a plurality of flow dividing holes 483 are opened on the cover 481, and one of the fluid inlets communicating with the atomizing chamber 450 is in butt joint with the opening 482 of the cover 481.

In one embodiment, the cover 481 is a hollow cubic structure, and a plurality of shunting holes 483 are distributed on the sidewalls of the remaining five sides except for the opening 482.

The size of the dispensing orifice 483 may be varied depending on the material to be dispensed, such as the viscosity of the fluid, the dispersion of the therapeutic material or the particle size, and is typically in the range of 5 microns to 100 microns, for example.

The atomizing chamber 450 is divided into an inner chamber and an outer chamber by the housing 481, wherein one phase fluid passes into the inner chamber and the other phase fluid passes into the outer chamber.

Referring to fig. 17, in an embodiment, the first connection pipe 430 is connected to the opening 482 of the flow divider 480, i.e., connected to the inner chamber, and the second connection pipe 440 is connected to the outer chamber.

The fluid (for example, gas) output from the first communicating pipe 430 enters the outer chamber through the plurality of branch holes 483 on the cover 481 and is mixed with the liquid to form bubbles, and the bubbles carry liquid droplets to be output through the nozzles on the wall of the atomizing chamber 450. Due to the arrangement of the plurality of nozzles facing to each other, when the focus of the lung is positioned on two sides of the bronchial wall, the liquid medicine can be accurately sprayed.

The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features. When technical features in different embodiments are represented in the same drawing, it can be seen that the drawing also discloses a combination of the embodiments concerned.

The above-mentioned embodiments only express several embodiments of the present application, and the description thereof is more specific and detailed, but not construed as limiting the claims. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the concept of the present application, which falls within the scope of protection of the present application.

Claims

1. An atomization catheter capable of targeting drug delivery comprises a catheter body, and is characterized in that one end of the catheter body is a near end, the other end of the catheter body is a far end capable of extending into a bronchus, a channel capable of conveying fluid from the near end to the far end is arranged inside the catheter body, an atomization head is arranged at the far end of the catheter body, and the fluid in the channel is atomized by the atomization head and then output;

the atomizing head is internally provided with an atomizing chamber for mixing multiphase fluid, the fluid is atomized through the atomizing chamber, the atomizing chamber is provided with a plurality of nozzles for atomized fluid, and the direction of at least two nozzles is different.

2. The targetable drug delivery atomizing catheter of claim 1, wherein the nozzle orifice is oriented in at least two of the following ways with reference to the direction of extension of the tube body:

a. axially along the tube body and towards the distal side;

b. radially outward along the tube body;

c. tangential to the tube body.

3. The targetable drug delivery aerosolization catheter of claim 1, wherein the aerosolization chamber has two orifices oriented, a first orifice axially distally along the body and a second orifice radially outwardly along the body.

4. The targetable drug delivery nebulizing catheter of claim 3, wherein the nebulizing head comprises:

a plurality of atomization chambers, each atomization chamber having a plurality of fluid inlets and the orifice of atomized fluid;

5. The nebulizing catheter of claim 4 wherein the nebulizing chamber comprises chamber walls and an inner chamber is enclosed by the chamber walls, each orifice opening onto a corresponding side of the chamber wall.

6. The targetable drug delivery nebulizing catheter of claim 5, wherein the first orifice opens into the distal chamber wall, the second orifice opens into the outer chamber wall, and each fluid inlet opens into the inner chamber wall.

7. The nebulizing catheter of claim 4, wherein a shunt is disposed within each nebulizing chamber, wherein one phase fluid is mixed with another phase fluid after being acted upon by the shunt.

8. The nebulizing catheter of claim 7 wherein the flow diverter is a cover with an opening on one side, the cover is provided with a plurality of flow diversion holes, and one of the fluid inlets communicating with the nebulizing chamber is butted with the opening of the cover.

9. The nebulizing catheter for targeted drug delivery according to claim 8, wherein the cover body is a hollow cubic structure, and a plurality of shunt holes are distributed on the side walls of the five sides except for the opening.

10. The targetable drug delivery nebulizing catheter of claim 8, wherein the nebulizing chamber is divided by the housing into an inner chamber and an outer chamber, wherein one phase of the fluid passes into the inner chamber and the other phase of the fluid passes into the outer chamber, and wherein the orifices are provided in a wall of the outer chamber.