RU95109450A - Methods for drug delivery to the respiratory system, the mode of delivery of the drug in one or both lungs of patients who are not inserted an endotracheal tube, METHOD aerosol delivery of drug in the lungs of patients: methods for drug delivery to a branched region of the respiratory system, the patient, the delivery catheter aerosol MEDICINES FOR LUNG PATIENTS (OPTIONS): CATHETER SYSTEM FOR DELIVERY OF AEROSOL OF MEDICINES IN LUNG PATIENTS, CATHETER SYSTEM A FOR DELIVERY aerosol therapy the patient's lungs, the suction catheter FOR A tracheal tube and method of making catheters for spraying liquids with gas - Google Patents

Methods for drug delivery to the respiratory system, the mode of delivery of the drug in one or both lungs of patients who are not inserted an endotracheal tube, METHOD aerosol delivery of drug in the lungs of patients: methods for drug delivery to a branched region of the respiratory system, the patient, the delivery catheter aerosol MEDICINES FOR LUNG PATIENTS (OPTIONS): CATHETER SYSTEM FOR DELIVERY OF AEROSOL OF MEDICINES IN LUNG PATIENTS, CATHETER SYSTEM A FOR DELIVERY aerosol therapy the patient's lungs, the suction catheter FOR A tracheal tube and method of making catheters for spraying liquids with gas

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Publication number
RU95109450A
RU95109450A RU95109450/14A RU95109450A RU95109450A RU 95109450 A RU95109450 A RU 95109450A RU 95109450/14 A RU95109450/14 A RU 95109450/14A RU 95109450 A RU95109450 A RU 95109450A RU 95109450 A RU95109450 A RU 95109450A
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catheter
drug
channel
distal
aerosol
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RU95109450/14A
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Russian (ru)
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RU2141351C1 (en
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Бэран Джордж
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Траделл Медикал Лимитед
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Claims (68)

1. Способ доставки лекарственного средства в дыхательную систему пациента, предусматривающий размещение интубационной трубки в дыхательной системе пациента, отличающийся тем, что размещают распыляющий катетер в дыхательной системе пациента и используют распыляющий катетер для получения аэрозоля лекарственного средства у дистального конца распыляющего катетера, при этом интубационная трубка находится в дыхательной системе пациента.1. A method of delivering a drug to the patient’s respiratory system, comprising placing an endotracheal tube in the patient’s respiratory system, characterized in that a nebulizing catheter is placed in the patient’s respiratory system and a nebulizing catheter is used to produce a drug aerosol at the distal end of the nebulizing catheter, wherein the endotracheal tube located in the respiratory system of the patient. 2. Способ по п.1, отличающийся тем, что использование распыляющего катетера далее включает подачу жидкого лекарственного средства к первому отверстию, расположенному у дистального конца распыляющего катетера, и подачу сжатого газа к второму отверстию, расположенному у дистального конца распыляющего катетера рядом с первым отверстием, для получения аэрозоля жидкого лекарственного средства у первого отверстия. 2. The method according to claim 1, characterized in that the use of a nebulizing catheter further includes supplying liquid medicine to a first opening located at the distal end of the nebulizing catheter, and supplying compressed gas to a second opening located at the distal end of the nebulizing catheter near the first opening , to obtain an aerosol of a liquid drug at the first hole. 3. Способ по п.1, отличающийся тем, что использование распыляющего катетера далее включает подсоединение контейнера под давлением, содержащего смесь лекарственного средства и жидкого газа-вытеснителя, к проксимальному концу распыляющего катетера, подачу смеси лекарственного средства и жидкого газа-вытеснителя через первый канал распыляющего катетера к первому дистальному отверстию, расположенному у дистального конца распыляющего катетера, и подачу сжатого газа через второй канал распыляющего катетера к второму отверстию, расположенному у дистального конца распыляющего катетера в непосредственной близости от первого отверстия для усиления процесса образования аэрозоля из лекарственного средства, поступающего из первого отверстия. 3. The method according to claim 1, characterized in that the use of a nebulizing catheter further includes connecting a pressure container containing a mixture of the drug and the liquid propellant to the proximal end of the nebulizing catheter, feeding the mixture of the drug and the liquid propellant through the first channel a nebulizing catheter to a first distal opening located at the distal end of the nebulizing catheter, and supplying compressed gas through a second channel of the nebulizing catheter to a second opening at the distal end of the nebulizing catheter in the immediate vicinity of the first opening to enhance the process of aerosol formation from the drug coming from the first opening. 4. Способ по п.3, отличающийся тем, что сжатый газ из второго отверстия направляют навстречу лекарственному средству и газу-распылителю, подаваемым из первого дистального отверстия. 4. The method according to claim 3, characterized in that the compressed gas from the second hole is directed towards the drug and the nebulizer gas supplied from the first distal hole. 5. Способ по п. 1, отличающийся тем, что осуществляют центрирование распыляющего катетера в интубационной трубке. 5. The method according to p. 1, characterized in that they center the nebulizing catheter in the endotracheal tube. 6. Способ по п.1, отличающийся тем, что размещение распыляющего катетера осуществляют через вспомогательный канал интубационной трубки. 6. The method according to claim 1, characterized in that the placement of the nebulizing catheter is carried out through the auxiliary channel of the endotracheal tube. 7. Способ по п.1, отличающийся тем, что осуществляют извлечение распыляющего катетера, в то время как интубационная трубка остается размещенной в дыхательной системе пациента. 7. The method according to claim 1, characterized in that the extraction of the nebulizing catheter is carried out, while the endotracheal tube remains located in the patient's respiratory system. 8. Способ по п.2, отличающийся тем, что создают пульсацию доставляемой жидкости. 8. The method according to claim 2, characterized in that it creates a pulsation of the delivered fluid. 9. Способ по п.8, отличающийся тем, что пульсацию осуществляют с частотой более 100 Гц. 9. The method according to claim 8, characterized in that the ripple is carried out with a frequency of more than 100 Hz. 10. Способ по п.8, отличающийся тем, что пульсацию прикладывают к проксимальному резервуару, на которого подают жидкое лекарственное средство. 10. The method according to claim 8, characterized in that the pulsation is applied to the proximal reservoir, which serves the liquid drug. 11. Способ по п.8, отличающийся тем, что пульсация связана с подачей менее 10 мл жидкого лекарственного средства. 11. The method according to claim 8, characterized in that the pulsation is associated with the supply of less than 10 ml of a liquid drug. 12. Способ по п. 1, отличающийся тем, что использование распыляющего катетера далее включает подачу электрического сигнала к дистальному концу распыляющего катетера для генерирования аэрозоля у указанного дистального конца. 12. The method according to p. 1, characterized in that the use of a nebulizing catheter further includes applying an electrical signal to the distal end of the nebulizing catheter to generate an aerosol at said distal end. 13. Способ по п.1, отличающийся тем, что осуществляют подачу коаксиального потока воздуха к дистальному концу распыляющего катетера, вызывая образование аэрозоля у дистального конца. 13. The method according to claim 1, characterized in that the supply of a coaxial air flow to the distal end of the nebulizing catheter, causing the formation of aerosol at the distal end. 14. Способ по п.1, отличающийся тем, что осуществляют увлажнение дыхательной системы пациента. 14. The method according to claim 1, characterized in that the hydration of the respiratory system of the patient. 15. Способ по п.1, отличающийся тем, что осуществляют: балансирование потока воздуха у дистального конца распыляющего катетера путем удаления воздуха через канал для подачи вакуума, проходящий через распыляющий катетер. 15. The method according to claim 1, characterized in that they carry out: balancing the air flow at the distal end of the nebulizing catheter by removing air through the channel for supplying vacuum passing through the nebulizing catheter. 16. Способ по п.1, отличающийся тем, что размещение распыляющего катетера далее включает получение сигнала о размещении распыляющего катетера относительно интубационной трубки. 16. The method according to claim 1, characterized in that the placement of the nebulizing catheter further includes receiving a signal on the placement of the nebulizing catheter relative to the endotracheal tube. 17. Способ по п.16, отличающийся тем, что сигнал является тактильным сигналом. 17. The method according to clause 16, wherein the signal is a tactile signal. 18. Способ по п.16, отличающийся тем, что получение сигнала далее включает получение сигнала об изменении давления у дистального конца интубационной трубки, как только мимо него проходит дистальный конец распыляющего катетера. 18. The method according to clause 16, wherein the signal further includes receiving a signal about the change in pressure at the distal end of the endotracheal tube as soon as the distal end of the nebulizing catheter passes by it. 19. Способ доставки лекарственного средства в одно или оба легких пациента, которому не вставлена интубационная трубка, отличающийся тем, что размещают распыляющий катетер в дыхательной системе пациента и используют его для получения аэрозоля лекарственного средства у дистального конца. 19. A method for delivering a drug to one or both lungs of a patient to whom an endotracheal tube is not inserted, characterized in that a nebulizing catheter is placed in the patient's respiratory system and used to obtain a drug aerosol at the distal end. 20. Способ доставки аэрозоля лекарственного средства в легкие пациента, отличающийся тем, что распыляют лекарственное средство у дистального конца катетера, размещенного в респираторном тракте пациента, при этом дистальный конец катетера нацелен в первом направлении, и нацеливают поток газа на распыленное лекарственное средство в направлении, противоположном первому. 20. A method for delivering a drug aerosol to the patient’s lungs, characterized in that the drug is sprayed at the distal end of the catheter located in the patient’s respiratory tract, the distal end of the catheter being aimed in the first direction, and the gas flow is directed towards the nebulized drug in the direction opposite to the first. 21. Способ по п.20, отличающийся тем, что первое направление на стадии распыления является дистальным направлением. 21. The method according to claim 20, characterized in that the first direction at the stage of spraying is a distal direction. 22. Способ по п.20, отличающийся тем, что первое направление на стадии распыления является проксимальным направлением. 22. The method according to claim 20, characterized in that the first direction at the stage of spraying is the proximal direction. 23. Способ по п.20, отличающийся тем, что стадия нацеливания характеризуется направлением потока газа от дистального конца интубационной трубки. 23. The method according to claim 20, characterized in that the targeting stage is characterized by the direction of the gas flow from the distal end of the endotracheal tube. 24. Способ по п.20, отличающийся тем, что указанный поток газа образован потоком воздуха при вдохе пациента через интубационную трубку. 24. The method according to claim 20, characterized in that said gas stream is formed by an air stream when the patient is inhaled through an endotracheal tube. 25. Способ доставки лекарственного средства к разветвленному участку дыхательной системы пациента, отличающийся тем, что размещают катетер в ветвь дыхательной системы человека, которая ведет к участку, отличному от участка, к которому будет доставляться лекарственное средство, подают поток воздуха через катетер, и распыляют лекарственное средство в дыхательной системе проксимально от того места, куда направляется поток воздуха, при этом поток распыленного лекарственного средства подают на участок без катетера. 25. A method for delivering a drug to a branched section of a patient’s respiratory system, characterized in that the catheter is placed in a branch of the human respiratory system, which leads to a section other than the site to which the drug will be delivered, an air stream is passed through the catheter, and the drug is sprayed means in the respiratory system proximally from the place where the air stream is directed, while the stream of nebulized drug is delivered to the site without a catheter. 26. Катетер для доставки аэрозоля лекарственного средства в легкие пациента, отличающийся тем, что имеет штифт катетера, выполненный с проксимальным концом и дистальным концом, канал по штифту катетера и соединение у проксимального конца с входным каналом для приема лекарственного средства в жидкой форме и соединение у дистального конца с дистальным отверстием, из которого выходит лекарственное средство, приспособление для распыления лекарственного средства, выходящего из дистального отверстия, для получения потока аэрозоля, состоящего из частиц лекарственного средства, и устройство для модификации потока аэрозоля, состоящего из частиц лекарственного средства. 26. A catheter for delivering an aerosol of a drug to the patient’s lungs, characterized in that it has a catheter pin made with a proximal end and a distal end, a channel along the catheter pin and a connection at the proximal end with an inlet for receiving the drug in liquid form and connection to the distal end with a distal opening from which the drug exits, a device for spraying the drug exiting the distal opening to obtain an aerosol stream consisting o of drug particles, and a device for modifying an aerosol stream consisting of drug particles. 27. Катетер по п. 26, отличающийся тем, что модифицирующее устройство включает отверстие для подачи вакуума рядом с дистальным отверстием, из которого выходит лекарственное средство, для удаления воздуха из распыленного аэрозоля. 27. The catheter according to claim 26, characterized in that the modifying device includes a hole for supplying a vacuum next to the distal opening from which the drug exits to remove air from the spray aerosol. 28. Катетер по п. 26, отличающийся тем, что модифицирующее устройство выполнено с приспособлением для уменьшения скорости частиц. 28. The catheter according to claim 26, characterized in that the modifying device is made with a device for reducing the speed of particles. 29. Катетер по п. 26, отличающийся тем, что модифицирующее устройство выполнено с приспособлением для увеличения ширины потока аэрозоля. 29. The catheter according to p. 26, characterized in that the modifying device is made with a device for increasing the width of the aerosol stream. 30. Катетерная система для доставки аэрозоля лекарственного средства в легкие пациента, отличающаяся тем, что имеет штифт катетера, выполненный проксимальным концом и дистальным концом, проходящий через штифт канал, соединяющийся у проксимального конца с входным каналом для введения лекарственного средства в жидкой форме и соединяющийся у дистального конца с дистальным отверстием, из которого может выводиться лекарственное средство, устройство для распыления лекарственного средства, которое выводится из дистального отверстия, устройство для управления потоком, соединенное с входным каналом, выполненное с проточной линией, связанной с входным отверстием, при этом проточная линия заполнена лекарственным препаратом, и вентилем, соединенным с проточной линией, для вызова пульсирующей подачи лекарственного средства через проточную линию. 30. A catheter system for delivering an aerosol of a drug to the patient’s lungs, characterized in that it has a catheter pin made with a proximal end and a distal end, passing through a pin channel connecting at the proximal end to the drug input channel in liquid form and connecting at the distal end with a distal opening from which the drug can be withdrawn, a device for spraying the drug, which is removed from the distal opening, the device GUT flow control connected to said inlet configured flow line connected to the inlet, wherein the flow line is filled with medicament and a valve connected to the flow line, to call a pulsating flow of drug through the flowline. 31. Катетерная система по п.30, отличающаяся тем, что устройство для управления потоком выполнено с участком возврата жидкости, связанным с проточной линией, при этом участок возврата жидкости организован таким образом, чтобы вызвать обратный поток жидкости через контроллер проточной линии, синхронизированный с пульсирующей подачей жидкости. 31. The catheter system according to claim 30, wherein the flow control device is configured with a fluid return portion connected to the flow line, wherein the fluid return portion is arranged so as to induce a reverse fluid flow through the flow line controller synchronized with the pulsating fluid supply. 32. Катетер для доставки аэрозоля в легкие пациента, отличающийся тем, что имеет штифт, выполненный с внешним цилиндрическим элементом конструкции, ограничивающим первый канал и заканчивающимся у дистального конца в первом дистальном отверстии, внутренним цилиндрическим элементом конструкции, ограничивающим второй канал, при этом внутренний цилиндрический элемент конструкции размещен в первом канале и заканчивается у дистального конца во втором дистальном отверстии, патрубком, присоединенным к проксимальному концу штифта, выполненным с первым входным каналом, связанным с первым каналом для подачи сжатого газа во внутренней области между внутренними и внешним цилиндрическими элементами конструкции, и вторым входным каналом, соединяющимся с вторым каналом для подачи жидкого лекарственного средства, при этом второе дистальное отверстие ориентировано относительно первого дистального отверстия, для распыления лекарственного средства из дистального кончика катетера. 32. A catheter for delivering an aerosol to the patient’s lungs, characterized in that it has a pin made with an external cylindrical structural element defining the first channel and ending at the distal end in the first distal opening, with an internal cylindrical structural element defining the second channel, while the inner cylindrical the structural element is placed in the first channel and ends at the distal end in the second distal hole, a pipe connected to the proximal end of the pin, made m with a first inlet channel connected to the first channel for supplying compressed gas in the inner region between the inner and outer cylindrical structural elements, and a second inlet channel connecting to the second channel for supplying liquid medicine, while the second distal opening is oriented relative to the first distal opening , for spraying the drug from the distal tip of the catheter. 33. Катетер по п.32, отличающийся тем, что имеет способный извлекаться стержень, размещенный во втором канале. 33. The catheter according to claim 32, characterized in that it has a removable shaft located in the second channel. 34. Катетер для доставки аэрозоля лекарственного средства в легкие пациента, отличающийся тем, что имеет штифт, содержащий первый канал, расположенный в центре штифта и приспособленный для доставки жидкого лекарственного препарата, множество каналов, расположенных по периферии вокруг первого канала и приспособленных для подачи газа, дистальное сопло для подачи жидкости, соединяющееся с первым каналом, и множество дистальных отверстий для подачи газа, соединенных с множеством каналов, при этом множество дистальных отверстий для подачи газа ориентировано относительно дистального отверстия для подачи жидкости таким образом, чтобы распылять жидкое лекарственное средство, выделяемое из канала для подачи жидкости. 34. A catheter for delivering an aerosol of a drug to the lungs of a patient, characterized in that it has a pin containing a first channel located in the center of the pin and adapted to deliver a liquid drug, a plurality of channels located peripherally around the first channel and adapted to supply gas, a distal fluid supply nozzle connecting to the first channel and a plurality of distal gas supply openings connected to the plurality of channels, the plurality of distal supplying holes r for oriented relative to the distal opening of the liquid feed so as to atomize the liquid medication is isolated from the liquid supply channel. 35. Катетерная система для доставки аэрозольной терапии в легкие пациента, отличающаяся тем, что имеет автономный распыляющий катетер, выполненный с дистальным концом для размещения в дыхательной системе пациента и проксимальным концом, при этом автономный распыляющий катетер включает штифт катетера, канал для подачи сжатого газа, проходящий через штифт катетера, дистальное отверстие для выхода газа, связанное с каналом для подачи сжатого газа, причем дистальное отверстие для выхода газа расположено у дистального конца распыляющего катетера, канал для подачи лекарства, проходящий вдоль по крайней мере части штифта катетера, и дистальное отверстие для подачи лекарства, соединенное с каналом для доставки лекарства, причем дистальное отверстие для подачи лекарства размещено в непосредственной близости от дистального отверстия для выхода газа так, что газ, поступающий из дистального отверстия для выхода газа, распыляет лекарство, подаваемое из дистального отверстия для подачи лекарства. 35. A catheter system for delivering aerosol therapy to the patient’s lungs, characterized in that it has a self-contained nebulizing catheter made with a distal end for placement in the patient’s respiratory system and a proximal end, wherein the self-contained nebulizing catheter includes a catheter pin, a channel for supplying compressed gas, passing through the catheter pin, a distal gas outlet, connected to a channel for supplying compressed gas, and a distal gas outlet is located at the distal end of the nebulizing cat ethera, a drug supply passage extending along at least a portion of the catheter pin, and a distal drug delivery port connected to the drug delivery channel, the distal drug delivery port being located in close proximity to the distal gas outlet port so that the gas coming from the distal opening for the exit of gas, sprays the medicine supplied from the distal opening for the supply of medicine. 36. Катетерная система по п.35, отличающаяся тем, что имеет интубационную трубку, выполненную с вентиляционным каналом, по которому может перемещаться распыляющий катетер. 36. The catheter system according to clause 35, characterized in that it has an endotracheal tube made with a ventilation channel through which the nebulizing catheter can move. 37. Катетерная система по п.35, отличающаяся тем, что имеет интубационную трубку, выполненную с вентиляционным каналом и вспомогательным каналом, расположенным рядом с вентиляционным каналом, при этом вспомогательный канал имеет дистальное отверстие в вентиляционный канал, так что дистальный конец вспомогательного канала выходит в вентиляционный канал рядом с его дистальным концом, а распыляющий катетер выполнен с возможностью прохода через вспомогательный канал. 37. The catheter system according to clause 35, characterized in that it has an endotracheal tube made with a ventilation channel and an auxiliary channel located next to the ventilation channel, while the auxiliary channel has a distal opening in the ventilation channel, so that the distal end of the auxiliary channel goes into a ventilation channel near its distal end, and a nebulizing catheter is configured to pass through an auxiliary channel. 38. Катетерная система по п.35, отличающаяся тем, что имеет центрирующее устройство, размещенное на штифте катетера близко к дистальному концу. 38. The catheter system according to clause 35, characterized in that it has a centering device placed on the pin of the catheter close to the distal end. 39. Катетерная система по п.35, отличающаяся тем, что имеет центрирующее устройство, имеет размер в расширенном состоянии и размер в сжатом состоянии, причем, оно принимает размер в расширенном состоянии, тогда когда оно развертывается в воздушном проходе. 39. The catheter system according to claim 35, characterized in that it has a centering device, has a size in an expanded state and a size in a compressed state, moreover, it takes a size in an expanded state when it is deployed in an air passage. 40. Катетерная система по п.35, отличающаяся тем, что центрирующее устройство имеет более одного размера в расширенном состоянии. 40. The catheter system according to clause 35, wherein the centering device has more than one size in the expanded state. 41. Катетерная система по п.35, отличающаяся тем, что центрирующее устройство имеет размер в расширенном состоянии, который может быть скорректирован после развертывания. 41. The catheter system according to clause 35, wherein the centering device has a size in the expanded state, which can be adjusted after deployment. 42. Катетерная система по п.35, отличающаяся тем, что центрирующее устройство включает газовые отверстия для центрирования. 42. The catheter system according to clause 35, wherein the centering device includes gas holes for centering. 43. Катетерная система по п.35, отличающаяся тем, что распыляющий катетер включает клапан, размещенный по крайней мере в одном из каналов. 43. The catheter system according to clause 35, wherein the nebulizing catheter includes a valve located in at least one of the channels. 44. Катетерная система по п.43, отличающаяся тем, что клапан размещен по крайней мере в одном из дистальных отверстий. 44. The catheter system according to item 43, wherein the valve is placed in at least one of the distal openings. 45. Катетерная система по п.43, отличающаяся тем, что клапан выполнен с возможностью управления от проксимального конца распыляющего катетера. 45. The catheter system according to item 43, wherein the valve is operable from the proximal end of the nebulizing catheter. 46. Катетерная система по п.43, отличающаяся тем, что клапан выполнен с возможностью привода в действие дистального конца катетера. 46. The catheter system according to item 43, wherein the valve is configured to drive the distal end of the catheter. 47. Катетерная система по п.43, отличающаяся тем, что клапан образован эластично закрывающимся кончиком. 47. The catheter system according to item 43, wherein the valve is formed by an elastically closing tip. 48. Катетерная система по п.35, отличающаяся тем, что имеет ограничитель на проксимальной части штифта катетера. 48. The catheter system according to clause 35, characterized in that it has a stopper on the proximal part of the catheter pin. 49. Катетерная система по п.35, отличающаяся тем, что имеет градуированные метки на штифте катетера. 49. The catheter system according to clause 35, characterized in that it has graduated marks on the pin of the catheter. 50. Катетерная система по п.35, отличающаяся тем, что имеет замковые соединители люерного типа на проксимальных входных каналах, соединенных с каналом для подачи сжатого газа и каналом для подачи лекарства. 50. The catheter system according to clause 35, characterized in that it has luer-type locking connectors on the proximal inlet channels connected to the channel for supplying compressed gas and the channel for supplying medication. 51. Катетерная система по п.35, отличающаяся тем, что имеет самозакрывающиеся проксимальные входные каналы, соединенные с каналом для подачи сжатого газа и каналом для подачи лекарства. 51. The catheter system according to claim 35, characterized in that it has self-closing proximal inlet channels connected to a channel for supplying compressed gas and a channel for delivering medicine. 52. Катетерная система по п.35, отличающаяся тем, что имеет средство для очистки от закупорок у дистального конца катетера. 52. The catheter system according to clause 35, characterized in that it has a means for cleaning from blockages at the distal end of the catheter. 53. Катетерная система по п.35, отличающаяся тем, что имеет способный извлекаться стержень, расположенный по крайней мере в одном из указанных каналов. 53. The catheter system according to clause 35, characterized in that it has a removable rod located in at least one of these channels. 54. Катетерная система по п.35, отличающаяся тем, что имеет полоску на штифте катетера. 54. The catheter system according to clause 35, characterized in that it has a strip on the pin of the catheter. 55. Катетерная система по п.35, отличающаяся тем, что имеет дефлектор, размещенный у дистального конца распыляющего катетера перед отверстиями. 55. The catheter system according to clause 35, characterized in that it has a deflector located at the distal end of the nebulizing catheter in front of the holes. 56. Катетерная система по п.35, отличающаяся тем, что штифт катетера включает проходящий через него третий канал и оптический волновод, проходящий через указанный третий канал. 56. The catheter system according to clause 35, wherein the catheter pin includes a third channel passing through it and an optical waveguide passing through the specified third channel. 57. Катетерная система по п.35, отличающаяся тем, что по крайней мере часть штифта, окружающего канал для доставки лекарства, изготовлена из материала, обладающего низкой эластичностью, так что контроль у дистального отверстия для выделения лекарства за потоком жидкости, поступающей по каналу для доставки лекарства, более важен, чем контроль за потоком у его дистального конца. 57. The catheter system according to clause 35, wherein at least a portion of the pin surrounding the drug delivery channel is made of a material having low elasticity, so that the control at the distal opening to isolate the drug for fluid flow entering the channel for drug delivery is more important than controlling the flow at its distal end. 58. Катетерная система по п.35, отличающаяся тем, что имеет вибрирующий материал, размещенный рядом с дистальным отверстием. 58. The catheter system according to clause 35, characterized in that it has a vibrating material located next to the distal opening. 59. Катетерная система по п.53, отличающаяся тем, что вибрирующий материал является пьезоэлектрическим материалом, который соединен с по крайней мере одним электрическим проводником, проходящим через штифт катетера. 59. The catheter system according to item 53, wherein the vibrating material is a piezoelectric material that is connected to at least one electrical conductor passing through the pin of the catheter. 60. Дренажный катетер для использования в интубационной трубке, размер которого подбирается таким, чтобы его можно было разместить в вентиляционном канале интубационной трубки, выполненный с аспирационным каналом для удаления слизи из респираторного тракта пациента, которому введена интубационная трубка, отличающийся тем, что имеет канал для подачи сжатого газа, проходящий по стенке дренажного канала рядом с аспирационным каналом, дистальное отверстие для выхода газа, соединяющееся с каналом для подачи сжатого газа и размещенное у дистального конца дренажного катетера, канал для подачи лекарства, проходящий по стенке дренажного катетера рядом с аспирационным каналом, и дистальное отверстие для подачи лекарства, соединенное с каналом для подачи жидкости, при этом отверстие для подачи лекарства размещено проксимально к дистальному отверстию для выхода газа, так что газ, выходящий из дистального отверстия для выхода газа, распыляет лекарство, выделяемое из дистального отверстия для подачи лекарства. 60. A drainage catheter for use in an endotracheal tube, the size of which is selected so that it can be placed in the ventilation duct of the endotracheal tube, made with an aspiration channel for removing mucus from the respiratory tract of the patient to whom the endotracheal tube is inserted, characterized in that it has a channel for compressed gas supply, passing along the wall of the drainage channel near the suction channel, a distal gas outlet for connecting to the channel for supplying compressed gas and located at the dist the far end of the drainage catheter, a drug supply passage extending along the wall of the drainage catheter next to the suction channel, and a distal drug delivery port connected to the fluid supply channel, wherein the drug delivery port is positioned proximal to the distal gas outlet, that the gas exiting the distal gas outlet is spraying the drug released from the distal drug delivery port. 61. Дренажный катетер по п.60, отличающийся тем, что дистальное отверстие для выхода газа и дистальное отверстие для подачи лекарства ориентированы проксимально относительно дистального дренажного отверстия, которое соединено с аспирационным каналом. 61. The drainage catheter according to claim 60, characterized in that the distal gas outlet and the distal drug delivery opening are oriented proximal to the distal drainage hole that is connected to the suction channel. 62. Дренажный катетер по п.60, отличающийся тем, что дистальное отверстие для выхода газа и дистальное отверстие для подачи лекарства ориентированы радиально относительно оси дренажного катетера. 62. The drainage catheter according to claim 60, characterized in that the distal gas outlet and the distal drug delivery opening are oriented radially relative to the axis of the drainage catheter. 63. Способ изготовления катетера для распыления жидкости с помощью газа, имеющий близко расположенные дистальные отверстия, размеры которых и расстояния между которыми выполнены с малыми допусками, отличающийся тем, что получают методом экструзии полимерную многоканальную трубку с относительно большими размерами, нагревают часть трубки до температуры перехода указанной трубки, осуществляют вытяжку указанной части трубки для получения конусообразной части с величиной вытяжки в интервале от 2 к 1 до 20 к 1, так что каналы в конусообразной части все более сближаются между собой, и формируют множество отверстий у дистального конца конусообразной части, при этом размер множества отверстий подбирают таким образом, чтобы распылять жидкость, поступающую по одному из указанных каналов, с образованием аэрозоля с помощью газа, подаваемого по другому из указанных каналов. 63. A method of manufacturing a catheter for spraying a liquid with a gas, having closely spaced distal openings, the dimensions of which and the distances between them are made with small tolerances, characterized in that the polymer multichannel tube with relatively large dimensions is obtained by extrusion, heat a portion of the tube to a transition temperature the specified tube, carry out the extraction of the specified part of the tube to obtain a cone-shaped part with a drawdown in the range from 2 to 1 to 20 to 1, so that the channels in the cone-shaped h The parts are becoming closer to each other and forming many holes at the distal end of the cone-shaped part, while the size of the many holes is selected in such a way as to spray the liquid coming through one of these channels, with the formation of aerosol using gas supplied through the other from these channels . 64. Способ по п.63, отличающийся тем, что формирование множества отверстий далее включает разрезание дистального конца конусообразной части. 64. The method according to item 63, wherein the formation of multiple holes further includes cutting the distal end of the cone-shaped part. 65. Способ по п.63, отличающийся тем, что осуществляют разрезание трубки до нужного размера, для получения штифтовой части распыляющего катетера. 65. The method according to p, characterized in that they cut the tube to the desired size, to obtain the pin part of the nebulizing catheter. 66. Способ по п.63, отличающийся тем, что воздействуют радиацией высокой энергии на часть указанной трубки. 66. The method according to p, characterized in that they are exposed to high energy radiation on a part of the specified tube. 67. Способ по п. 63, отличающийся тем, что катетер используют в дыхательной системе. 67. The method according to p. 63, characterized in that the catheter is used in the respiratory system. 68. Способ по п.63, отличающийся тем, что нагревание далее включает нагревание трубки до температуры в интервале от расплавленного состояния до ее стеклообразного состояния. 68. The method according to p, characterized in that the heating further includes heating the tube to a temperature in the range from the molten state to its glassy state.
RU95109450/14A 1994-06-17 1995-06-16 Method of delivery of medicine to patient's respiratory system; method of delivery of medicine to one or two patient's lungs into which no intubation tube is installed; method of delivery of medicine aerosol to patient's lungs; method of delivery of medicine to branching part of patient's respiratory system; catheter for delivery of medicine aerosol to patient's lung (versions); catheter system for delivery of medicine aerosol to patient's lungs; catheter system for delivery of aerosol therapy to patient's lungs draining catheter for use in intubation tube and method of manufacture of catheter for spraying liquid by means of gas RU2141351C1 (en)

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