JP2008295849A - Spray container - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a spray container, capable of effectively spraying chemical to a subject part such as an affected part even where the subject part is apart from the axial line of a nozzle. <P>SOLUTION: The spray container is provided with a hollow cylindrical member provided with a flow passage for letting chemical flow, and the nozzle 25 installed on the hollow cylindrical member, having a spray mouth 24 formed at a tip to communicate with the flow passage. The flow passage at the tip of the nozzle 25 is provided with an inclined flow passage 23 inclined to the axial line, and the spray mouth 24 is diagonally opened to the axial line. The chemical can thus be diagonally sprayed to the axial line. Flow of the chemical at the spray mouth may be deviated, so that the chemical is sprayed diagonally. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention relates to a spray container for spraying a chemical solution, and particularly to a spray container (or a spray container for nasal spray) useful for spraying nasal fluid.

  In order to spray nasal fluid, a nasal spray including a container main body that stores the nasal fluid and a nozzle that is attached to the container main body and can be moved forward and backward using a spring is used. In such a spray container, as shown in FIG. 24, a concave portion 132 is formed on the inner wall of the tip portion of the nozzle 130, and a through hole 133 formed along the central axis is formed from the concave portion. The hole is opened at the spray port 134. A spiral recess 135 extending in the radial direction is formed from the spray port. In such a spray nozzle, the nozzle tip is inserted into the nasal cavity, the nozzle 130 is moved forward and backward in the axial direction, and the drug solution is pumped, whereby the droplet of the drug solution can be sprayed at a wide angle while rotating.

  However, since the medicinal solution is sprayed at a wide angle, it is difficult to efficiently spray the medicinal solution to the affected part (the lower turbinate and its surrounding area where rhinitis is likely to occur). In addition, although it is necessary to spray the drug solution by changing the insertion angle with respect to the nasal cavity, the spray angle is wide, so even if the insertion angle is changed, a specific angle (especially the tip of the nozzle with respect to the direction in which the nasal cavity extends) The medicinal solution can be sprayed on the affected area only in the direction of pressing on the lower wall or the downward angle), and the medicinal solution is sprayed mainly on the upper part of the nasal cavity at the normal insertion angle, and the medicinal solution cannot be effectively sprayed on the affected part. In particular, when inhaled by a nasal slide, the flow rate, flow rate, and flow direction of air greatly change, so that the spray efficiency of the drug solution on the affected area is greatly reduced, and a sufficient therapeutic effect cannot be obtained.

JP-A-8-280807 (Patent Document 1) includes a container that separates and stores a solid component and a liquid component through an easily breakable thin film, and a liquid ejecting member that can be attached to the container. In addition, there is disclosed a spray container capable of breaking an easily breakable thin film with a liquid suction pipe of the liquid ejecting member as the liquid ejecting member is attached. Also in this spray container, a spray port is formed along the central axis at the tip of the nozzle. Therefore, the same problem as described above occurs.
JP-A-8-280807 (Claims, FIG. 2)

  Accordingly, an object of the present invention is to provide a spray container (or nasal spray container) that can effectively spray a drug solution onto an application site (affected area, etc.) even if the application site (affected area, etc.) is off the axis of the nozzle. It is to provide.

  Another object of the present invention is that it can be efficiently sprayed to the application site (the affected part such as the lower turbinate and the lower part thereof) even if the spraying range is narrowed, and the site other than the application site (the vicinity of the outer nostril, the ear canal, etc.) It is an object of the present invention to provide a spray container (or nasal spray container) effective in avoiding the spraying of a chemical solution.

  As a result of intensive studies to achieve the above-mentioned problems, the present inventors opened the spray port (or spray port) at the nozzle tip portion in an oblique direction, or opened the spray port (or spray port) at the nozzle tip portion. In contrast, if the drug solution is pressurized and supplied with the flow distribution biased, the drug solution can be sprayed in an oblique direction away from the axis of the nozzle and applied to the affected area (peripheral areas such as the lower turbinates or the lower part of the lower nasal turbinates where inflammation is easily caused by rhinitis) The present invention has been completed by finding that the chemical solution can be sprayed and adhered efficiently.

  That is, the spray container of the present invention has a hollow cylinder provided with a flow channel for circulating a chemical solution, and a spray port that is attached to the tip of the hollow cylinder and communicates with the channel. Nozzle. In such a spray container, the nozzle inclines the chemical liquid with respect to the axis line by at least one of the inclination of the opening direction of the spray port with respect to the axis line (center axis line) of the nozzle and the deviation of the chemical liquid flow rate at the spray port. Can be sprayed in the direction. The flow path at the tip of the nozzle may include an inclined flow path that is inclined with respect to the axis (center axis) and reaches the spray port. The inclined channel may be inclined at an angle of about 15 to 45 ° (for example, 20 to 40 °, particularly 25 to 35 °) with respect to the axis. The spray container has a container body having a container for containing a chemical solution, a dip tube in which one end can be immersed in the chemical solution, a first holding the other end of the tube and containing a spring. A cylindrical member, and a slide member that is slidably disposed in the first cylindrical body and has a flow path for circulating a chemical solution from the first cylindrical body, and is movable forward and backward by a spring. The second cylindrical body for guiding the chemical solution from the flow path of the slide member to the spray port of the nozzle tip as the slide member moves forward and backward may be provided. The second cylindrical body is connected to the slide member, and has a hollow stem having a flow path for guiding the chemical solution from the flow path of the slide member, and is connected to the stem, and the finger is hooked. You may be comprised by the outer cylinder which has a latching part which can be, and the insert which is arrange | positioned in this outer cylinder and forms an annular flow path between the downstream end of the said stem and a spraying opening. Regarding the annular flow path, a plurality of protrusions may be formed in the upstream portion of the insert, extending in the axial direction at intervals in the circumferential direction, and slidable within the outer cylinder. The width of the annular flow path from the downstream end may be reduced.

  A concave portion (for example, a curved concave portion or a depression) may be formed in the nozzle tip portion, and the spray port may be opened in this concave portion. Furthermore, at least the tip portion of the nozzle may be displaced from the axis in the radial direction or may be inclined. Furthermore, the nozzle tip portion may have an inclined surface inclined with respect to the axis, and the spray port may be opened in an oblique direction on this inclined surface. Furthermore, you may give the notification means for showing the spray direction of a chemical | medical solution in the appropriate place of a spray container.

  Since such a spray container can spray the chemical liquid in an oblique direction with respect to the nozzle axis, the chemical liquid can be effectively sprayed even on a site to be processed (applied site) that is off the axis of the nozzle. Therefore, the spray container is useful as a nasal spray container for efficiently spraying a medicinal solution to an application site (affected part) of the nasal cavity.

  The present invention also includes a method of spraying a chemical using the spray container, and a method of spraying the chemical in an oblique direction while reducing a spray area of the chemical.

  In the present invention, since the medicinal solution can be sprayed in an oblique direction with respect to the central axis of the spray container, even if the application site (the affected part such as the lower turbinate and / or its surrounding area) deviates from the axis of the nozzle, the application site The chemical solution can be effectively sprayed on the affected area. In addition, even if the spraying range is narrowed, it can be efficiently sprayed to the application site (affected area, etc.), and it is possible to avoid spraying the drug solution to a site other than the application site. Therefore, the chemical liquid can be used effectively and the amount of one injection can be reduced, which is also effective for preventing dripping after injection.

  Hereinafter, the present invention will be described in detail with reference to the accompanying drawings as necessary. FIG. 1 is a schematic view showing the spray container of the present invention, and FIG. 2 is a schematic cross-sectional view of the nozzle tip of the spray container shown in FIG.

  The spray container has a container main body 1 having a storage portion for storing a chemical solution, a dip tube (a suction tube or a suction tube) 2 in which one end portion can be immersed in the chemical solution in the container main body, and the other end of the tube. A first cylinder 3 that holds the portion in communication with the flow path of the tube 2 and that houses the spring 5, and is slidably disposed in the first cylinder and the first cylinder 3 and a slide member 8 that can be moved forward and backward by a spring 5 and the tip of the nozzle 25 as the slide member 8 moves forward and backward. And a second cylinder 13 for guiding to the spray port 24 of the part. In addition, in order to effectively suck even a small amount of the chemical solution, a concave portion or a recess in which the chemical solution can flow in or collect and the opening end of the dip tube 2 can be disposed at the bottom of the container body 1 is stored. (In particular, a recess or depression having a deep central portion through an inclined surface having a cross-sectional shape such as a V shape or a U shape) is formed.

  The first cylindrical body 3 is formed on the downstream side of the cylindrical mounting portion 4 for mounting by inserting the end portion of the immersion tube 2, and one end portion of the spring 5 is mounted. It is composed of a possible cylindrical inner tube 6 and an outer tube 7 formed by extending in a downstream direction from the cylindrical mounting portion in the form of a double tube, and the other end of the spring 5 is formed in the cylindrical inner tube. The spring 5 extends in the downstream direction from the tube 6 and can be expanded and contracted in the outer tube 7.

  The slide member 8 includes a holding portion 9 to which the other end portion of the spring 5 can be attached or fixed, a flange portion 10 extending radially from the holding portion and slidable in the outer cylinder, A cylindrical extending portion 11 that extends in the upstream direction from the flange portion and forms an annular flow path with the inner wall of the outer cylinder 7, and a predetermined interval in the outer circumferential direction of the flange portion 10. A notch (not shown) for forming a flow path is formed, and a cylindrical projecting portion 12 that extends in the downstream direction from the holding portion 9 and has a tapered (or conical) tip portion. ing. A plurality of protrusions extending in the axial direction are formed at predetermined intervals on the outer peripheral surface of the cylindrical protruding portion in order to flow the chemical solution in the downstream direction through the annular flow path and the cutout portion.

  Further, the second cylindrical body 13 has a mounting recess 14 in which a plurality of protrusions of the cylindrical protrusion 12 of the slide member 8 can be mounted, and a hollow having a flow path extending in the axial direction from the mounting recess. In order to seal between the stem 15 and the stem and the outer tube 7, an annular sealing material (a trumpet-like sealing material) is formed at the upstream end of the stem 15 and expands in the upstream and downstream directions. ) 16, 17; an outer cylinder 18 mounted on the downstream side of the stem 15; and an annular channel 21 disposed in the outer cylinder between the downstream end of the stem 15 and the spray port 24. It is comprised with the cylindrical insert 19 for forming. The outer cylinder 18 is formed with a hooking portion 20 on which a finger can be hooked to move the slide member 8 forward and backward in the axial direction.

  A plurality of protrusions extending in the axial direction at intervals in the circumferential direction and slidable in the outer cylinder 18 are formed in the upstream portion of the insert 19. An annular flow from the downstream ends of these protrusions is formed. The slit width of the path 21 is reduced. Therefore, the chemical solution supplied through the hollow part of the dip tube 2 is narrowed in the process of flowing in the downstream direction through the hollow part of the stem 15 and the annular channel 21 formed between the outer cylinder 18 and the insert 19. Pressurized and sprayed or sprayed from the spray port 24.

  In such a spray container, since the chemical liquid from the spray port 24 is sprayed at a wide angle, if there is an application site at a site off the axis of the nozzle 25, the chemical solution cannot be effectively sprayed onto the application site. Therefore, an inclined flow path 23 that is inclined at an angle of 25 to 35 ° with respect to the axis of the nozzle and reaches the spray port 24 is formed at the tip of the nozzle 25 of the spray container. Further, in order to form a space in the downstream inner wall at the tip of the insert 19, a recess 22 smaller than the outer diameter of the insert 19 is formed in the inner wall of the nozzle tip, and a passage extending in the axial direction from this recess. The inclined channel 23 penetrates in an oblique direction. Moreover, in order to show the spray direction of a chemical | medical solution, the marker (the arrow which shows a spray direction, not shown) is given to the said latching | locking part.

  In such a spray container, the flow path at the tip of the nozzle is provided with the inclined flow path 23 opened obliquely at the spray port 24, so that the chemical liquid can be sprayed in an oblique direction with respect to the axis of the nozzle. In addition, since the spiral recess from the spray port is not formed at the tip of the nozzle, the chemical solution can be prevented from spreading to a wide angle, and the spray range can be narrowed. Therefore, even if the application site (the affected part such as the lower turbinate or its surrounding area) deviates from the axis of the nozzle, the medicinal solution can be effectively sprayed to the application site (the affected part) having a narrow range. For example, as shown in FIG. 3, when spraying nasal drops, the nozzle tip in the direction in which the nasal cavity H extends without pressing the nozzle tip against the lower wall of the nasal cavity and directing it downward in the direction in which the nasal cavity H extends. By inserting and spraying, the drug solution can be efficiently sprayed onto the application site (the affected part such as the lower turbinate or the lower part thereof) A.

  The spray container is not limited to the above structure, and various spray mechanisms can be employed. For example, if necessary, the spray container may be an aerosol container containing a propellant, but is usually a piston-type spray container that does not contain a propellant. The spray container usually has a hollow cylinder provided with a flow path for circulating the chemical solution in the container body, and a nozzle that is attached to the hollow cylinder and has a spray port that communicates with the flow path formed at the tip. And. Furthermore, a piston-type spray container usually has a container body having a container for containing a chemical, a dip tube in which one end can be immersed in the chemical, and a hollow that holds the other end of the tube. A piston mechanism that is formed in the cylinder and can suck up the liquid chemical from the tube as it is advanced and retracted by the spring (this piston mechanism is usually used to regulate the leakage of the chemical liquid in the cylinder as it advances and retracts. And a narrowing flow path for pressurizing the chemical liquid sucked up by the piston mechanism as it advances and retreats, and a spray port leading to the flow path.

  In addition, the hollow cylinders of these spray containers are not limited to the hollow cylinders configured by the first to second cylinders, but various cylinders (for example, about 2 to 5 hollow cylinders). Can be configured.

  The first cylindrical body does not need to be formed into a double tubular shape with an inner tube and an outer tube, and communicates with the hollow portion of the dip tube in which one end is immersed in the chemical solution in the container body. It only needs to have a holding part capable of holding the other end part and be able to accommodate the spring. This spring is housed in the first cylinder, and the end of the spring is often held and fixed.

  The slide member only has to be slidably disposed in the first cylindrical body and has a flow path for circulating the chemical solution from the first cylindrical body, and can be moved forward and backward by a spring. The flow path is not limited to the annular flow path formed by the notch portion or the like, but may be formed by a through hole formed in the shaft core, a through hole penetrating the flange portion, or the like. If necessary, the slide member may include an annular sealing material that can slide with the inner wall of the first cylinder in order to restrict leakage of the chemical solution in relation to the inner wall of the first cylinder.

  The second cylindrical body only needs to have a flow path for guiding the chemical solution from the flow path of the slide member to the spray port of the nozzle tip as the slide member advances and retreats. In order to pressurize the chemical liquid as the slide member advances and retracts, it is preferable that the flow path width on the spray port side is narrowed. Moreover, in order to improve the spray efficiency of a chemical | medical solution, it is preferable to make a chemical | medical solution merge and distribute | circulate to a spraying port. For example, as described above, it is preferable that the annular flow path width (interval of the annular slit) is reduced on the downstream side, and the chemicals are merged and led to the spray port. The second cylindrical body usually has a latching portion on which a finger can be latched in order to move the slide member forward and backward.

  The structure of the second cylindrical body is not limited to the above-described structure, and it is sufficient that the chemical liquid can be sprayed from the spray port at the tip of the nozzle as the slide member moves forward and backward, and the slide member (for example, the downstream end of the slide member) And a hollow stem having a flow path for guiding a chemical solution from the flow path of the slide member, and an outer cylinder connected or connected to the stem (for example, the downstream end portion of the stem). In this outer cylinder, it can be constituted by an insert for forming an annular flow path between the downstream end of the stem and the spray port. Although the latching portion can be formed at an appropriate position of the second cylinder, it is usually formed on the outer cylinder in many cases. The stem is slidable while being sealed along the inner wall of the first cylinder (in the above example, the outer cylinder). In many cases, the tip of the second cylinder constitutes a nozzle tip.

  The tip of the nozzle may be formed with a spiral groove or recess that leads to the spray port, but in order to spray the drug solution efficiently on the application site by increasing the droplet diameter, the rotational force of the droplet In order to reduce this, it is not necessary to form a spiral groove or recess at the tip of the nozzle. Moreover, it replaces with a helical groove | channel or a helical recessed part, a recessed part is formed in a nozzle front-end | tip part, and a spraying opening may be opened by this recessed part. FIG. 4 is a schematic perspective view showing another example of the spray container of the present invention. In the following example, the spray container shown in FIGS. 1 to 3 and members or elements having the same function may be described with reference numerals common to FIGS.

  In FIG. 4, the channel extending in the axial direction is inclined at an angle of about 28 to 32 ° at the tip of the nozzle 35 to form the inclined channel 23, and the spray port 34 of the inclined channel 23 is Open in an oblique direction. Further, the nozzle 25 has an inclined side wall 31a at the tip surface, and a cutout recess 31 (in this example, an inverted triangular or inverted conical recess) having a circular planar shape is formed. A spray port 34 of the inclined channel 23 is opened at the side wall 31a.

  When the nozzle having such a structure is used, the spray liquid collides with the inclined side wall 31a of the recess 31 or the liquid droplet diameter of the chemical liquid is reduced without significantly reducing the spray port ratio with respect to the application site. spread. Therefore, the chemical solution can be efficiently sprayed on the application site.

  In addition, not only the recessed part of the said shape but various recessed parts (For example, curved recessed parts, such as a U-shaped cross section, a U-shaped cross section, and a dish shape), can be formed in the nozzle front-end | tip part. Further, the opening part of the spray port in the concave part may be an inclined wall or a flat part, may be the center of the concave part, or may be a part deviated from the central part.

  Further, when the distance between the tip of the insert and the spray port is increased, the droplet diameter is increased and the spray range is narrowed. For this reason, the droplet diameter and the spray range may be adjusted by combining the distance between the tip of the insert and the spray port and the formation of the recess. Further, in such a combination, the recess may be a radial groove or recess extending from the spraying port, a spiral (or spiral) groove, or a spiral (or spiral) recess.

  In the present invention, from the nozzle to the axis (center axis) due to at least one of the inclination of the opening direction of the spray port with respect to the axis (center axis) and the deviation (bias) of the chemical flow rate at the spray port. The chemical solution can be sprayed in an oblique direction. In order to spray the chemical liquid in an oblique direction with respect to the central axis, both the inclination in the opening direction and the flow rate deviation may be provided. For example, a chemical solution is formed by tilting the opening direction of the spray port (opening in an oblique direction) and making the flow rate from the other side larger than the flow rate from one side with the spray port as the central axis to form a bias in the flow rate. May be sprayed from the spray nozzle.

  In order to incline the opening direction of the spray port with respect to the axis (center axis) of the spray container, it is useful to form an inclined channel that is inclined with respect to the axis and reaches the spray port in the channel at the tip of the nozzle. It is. The angle of the inclined flow path can be selected from a range of about 10 to 60 ° with respect to the axis (center axis) of the spray container or nozzle, and is usually 15 to 45 °, preferably 20 to 40 °, more preferably 25 to 25 °. It is about 35 ° (for example, 30 ± 2.5 °). If a channel inclined at such an angle is formed, the drug solution can be efficiently sprayed onto the application site (affected site) even if the insertion angle with respect to the nasal cavity is different or the viscosity of the drug solution varies. Moreover, spraying can be performed in a narrow spraying range, and the chemical solution can be used effectively.

  The form of the inclined channel is not limited to the above-described structure. For example, as shown in FIG. 5, the tip of the nozzle is not passed through the channel extending in the axial direction from the recess 22 formed on the inner wall of the tip of the nozzle 25. The inclined flow path 43 which penetrates the wall of a part in the diagonal direction may be sufficient. As illustrated in FIG. 6, an inclined flow path 44 that penetrates the wall of the nozzle tip portion in an oblique direction without forming a recess in the inner wall of the tip portion of the nozzle 25 may be used. Further, as shown in FIG. 7, in the nozzle having the inclined channel having the same structure as in FIG. 2, the concave portion 51 may be formed on the side opposite to the inclined direction of the inclined channel 45 in the tip portion of the nozzle 35. Good. Further, as shown in FIG. 8, without using the insert to form the annular flow path, the flow path 47 extending in the axial direction, and the inclination from the flow path to the spray port at the tip of the nozzle 25. The channel 46 may be formed.

  Further, the nozzle tip may include a nozzle tip in which a spray port is formed. For example, as shown in FIG. 9, in a structure having an inclined flow path corresponding to FIG. 6, a nozzle tip 61 having an inclined flow path (inclined through hole) 44 may be attached to the tip, as shown in FIG. Thus, in the structure corresponding to FIG. 7, the nozzle tip 62 having the inclined flow path (inclined through hole) 45 and the concave portion 51 may be attached to the tip portion, and corresponds to FIG. 8 as shown in FIG. 11. In a structure having an inclined flow path, a nozzle chip 63 having a flow path 47 formed along the axis and an inclined flow path 46 inclined from the flow path to the spray port may be attached to the tip portion. .

  Further, in order to incline the opening direction of the spray port with respect to the axis, an inclined surface inclined with respect to the axis is formed at the tip of the nozzle, and the spray port is opened obliquely with respect to the axis by this inclined surface. May be. FIG. 12 is a schematic cross-sectional view showing another example of the spray container of the present invention. An inclined surface 71 inclined with respect to the axis is formed at the tip of the nozzle 70, and the spray port 74 extends along the axis on this inclined surface. On the other hand, it opens in an oblique direction. In this example, the inclined flow path 73 is formed in a direction orthogonal to the inclined surface 71, and the spray port 74 is opened on the inclined surface. Further, in order to reduce the rotational force of the spray droplets, a recess 75 is formed on the tip surface. Further, a recess 72 is formed in the inner wall of the tip portion, and a space can be formed between the tip surface of the cylindrical insert 79 and the inner wall of the tip portion.

  FIG. 13 is a schematic cross-sectional view showing still another example of the spray container of the present invention. The downstream end of the flow path at the tip of the nozzle 80 is formed as a spherical space, and the tip of the insert 89 is A curved concave portion 82 is formed along the curved wall on the inner wall of the tip. Further, an inclined surface 81 inclined with respect to the axis is formed at the nozzle tip, and an inclined channel 83 is formed in a direction orthogonal to the inclined surface 81, and the inclined surface 81 has a spray port extending from the curved recess 82. 84 opens in an oblique direction with respect to the axis (in this example, a direction orthogonal to the inclined surface 81). Note that the spray port 84 is formed at a location that is displaced in the radial direction from the axis of the nozzle.

  FIG. 14 is a schematic sectional view showing another example of the spray container of the present invention. In this example, a mounting recess for mounting the nozzle chip 96 is formed in an inclined portion inclined with respect to the axis line in the tip portion of the nozzle 90. The nozzle chip 96 mounted in the mounting recess includes an inclined surface 91 formed to be inclined corresponding to the inclined portion, a surface recessed portion 95 having an inverted trapezoidal cross section formed on the inclined surface 91, and the recessed portion. And an inclined flow path 93 formed in a direction perpendicular to the inclined surface 91 and penetrating between the front surface recessed portion and the rear surface recessed portion. And a ring-shaped member 97 provided with a spray port 94 opened in the inclined surface 91 in an oblique direction (a direction orthogonal to the inclined surface) with respect to the axis, and mounted in the ring-shaped member, A cylindrical core 98 for forming an annular flow path 99c is provided between the inner wall of the ring-shaped member 97. Further, a flow path 99a extending through the nozzle in the axial direction is opened in the mounting portion of the core 98, and the chemical solution from this flow path is formed by the mounting recess and the bottom surface of the core 98. A diffusion flow path 99b for guiding the chemical solution outward in the radial direction, an annular flow path 99c communicating with the flow path, and a convergence flow path 99d that converges in the central direction from the annular flow path and reaches the recess. And sprayed from the spraying port 94.

  Even in the case of a spray container having a nozzle having such an inclined surface and an opening for spraying, the chemical liquid can be sprayed in an oblique direction with respect to the axis of the nozzle, and the spray efficiency of the chemical liquid on the application site (eg, affected area) can be improved.

  In order to spray the chemical liquid in an oblique direction with respect to the axis, a nozzle whose chemical liquid flow rate is uneven at the spray port may be used. FIG. 15 is a schematic sectional view showing another example of the spray container of the present invention. In this example, a recess 105 is formed on the outer wall surface of the tip of the nozzle 100 and a recess 102 is also formed on the inner wall surface. A through hole 103 is formed between the recesses, and a spray port 104 is opened in the axial direction in the recess 105 on the outer wall surface. In the axial direction of the nozzle, a hollow portion that leads to the spray port is formed, and in this hollow portion, a cylindrical insert 109 having a tip end surface inclined in an oblique direction is mounted, and the inner wall of the nozzle and the side wall of the insert 109 are mounted. An annular flow path leading to the spray port 104 is formed between the two. For this reason, a bilaterally asymmetric and uneven flow space 110 is formed between the inclined front end surface of the insert 109 and the inner wall surface of the nozzle front end portion in which the axial distance increases (or decreases) in the radial direction.

  FIG. 16 is a schematic sectional view showing still another example of the spray container of the present invention. In this example, a nozzle tip 111 having a spray port 104 having the structure shown in FIG.

  Even in such a spray container, the chemical liquid tends to stay on one side in the radial direction with respect to the central axis of the nozzle, and the flow rate of the chemical liquid increases on the other side, so the spray port is formed along the central axis of the spray container. Even if it is carried out, a chemical | medical solution can be sprayed inclining in the diagonal direction with respect to an axis line.

  In addition, a recessed part is not necessarily required in the outer wall surface and / or inner wall surface of the spray nozzle of a nozzle front-end | tip part. Moreover, you may comprise a spray container combining the said structure suitably. For example, a spray port that opens obliquely with respect to the axis may be combined with a structure that deflects the chemical flow rate at the nozzle tip, and the chemical flow rate is deflected at the spray port formed on the inclined surface and the nozzle tip. You may combine with a structure.

  In the present invention, the chemical solution can be sprayed in an oblique direction. Therefore, it is useful to provide the spray container with a notification means for indicating the spray direction of the chemical solution. This notification means may be in the form of a container (including a latch), and may be a display means or an instruction means (a marker for indicating the spraying method or direction, a display for indicating the spraying method or direction, etc.). There may be. In the example shown in FIG. 17, the nozzle 110 is formed so as to be displaced in the radial direction from the central axis of the spray container, and a hooking portion 111 on which a finger (for example, an index finger) can be hooked is formed at the lower part of the nozzle 110. In the example shown in FIG. 18, the nozzle 112 is displaced in the radial direction from the center axis of the spray container and is inclined, and a hooking portion 113 on which a finger (for example, an index finger) can be hooked is formed below the nozzle 112. Has been. 19 and 20 correspond to FIGS. 17 and 18, respectively, and the nozzles 110 and 112 are formed on caps 120 and 121 that can be attached to the container body by screwing or the like. These caps 120 and 121 can be sprayed with a chemical solution by attaching them to the container body and moving the latching portions 111 and 113 forward and backward, respectively. These spray containers may have the same internal structure as shown in FIG.

  In this way, when at least the nozzle is displaced or inclined in the radial direction from the axis of the container, the latching portion formed in the opposite direction to the nozzle misalignment direction or the inclination direction (particularly, the hook extending in the opposite direction). It is easy to put a finger on the stopper or the latching part formed in a wide area, and the nozzle is positioned on the lower side of the nasal cavity, and the latching part is positioned on the outer side away from the nose and spraying is facilitated. Therefore, when such a container is used, even if the drug solution is sprayed in an oblique direction, the drug solution can be efficiently sprayed onto the affected area simply by being naturally inserted into the nasal cavity and sprayed.

  Further, display means or instruction means may be provided at appropriate positions of the spray container. For example, as shown in FIG. 21, a marker 116 indicating the spraying direction may be applied to a latching portion 114 having a triangular planar shape formed in the lower part of the nozzle, and the planar shape is rectangular as shown in FIG. You may give the marker 116 which shows the spraying direction to the latching | locking part 115. FIG.

  Note that the shape of the latching portion is not particularly limited, and the planar shape may be a polygonal shape, an elliptical shape, or a circular shape. The marker may be a marker such as an arrow indicating the spraying direction, and the marker may be formed by engraving, printing, uneven shape, or the like.

  The container body and the nozzle may be connected by a connecting means such as a screw type, and as shown in FIG. 23, the container body 1 and the nozzle 25 may be connected in a hinged manner via a hinge portion 120. Good.

  In the present invention, various chemical solutions can be effectively sprayed on the application site. In particular, compared with a conventional spray container, the chemical solution can be sprayed in an oblique direction while reducing the spray area of the chemical solution. Therefore, even if the application site such as the affected area is deviated from the central axis direction of the spray container, it is possible to effectively spray the liquid medicine onto the application site and reduce the amount of one injection and prevent dripping after injection. can do.

  In addition, the chemical solution can be effectively sprayed on the application site without being affected by the viscosity of the chemical solution and regardless of the presence or absence of the air flow (change in the air flow due to the presence or absence of inhalation). The type of the chemical solution is not particularly limited, and may be, for example, an insecticide, but may be a drug in a cavity such as the oral cavity, nasal cavity, or ear canal, such as a disinfectant solution or an anti-inflammatory solution. A typical medicinal solution is a nasal solution.

  The spray container may be non-medical, for example, a spray container for supplying water to plants, but for medical use, for example, for spraying a drug solution on an affected part (bruise, cold feeling part, infected part, inflamed part) Suitable as a spray container. In particular, it is useful for spraying a chemical solution to a site deviating from the axis of the nozzle.

  The spray container of the present invention can be applied to various application sites, for example, not only the nasal cavity but also various affected parts (for example, throat, oral cavity). A preferred application site is the nasal cavity. Therefore, the spray container of the present invention often constitutes a nasal spray container.

  Hereinafter, the present invention will be described in more detail based on examples, but the present invention is not limited to these examples.

Comparative Example 1
The spray characteristics by the nasal spray container having the conventional nozzle tip shown in FIG. 24 were evaluated as follows. The spray container has a spray opening that opens along the central axis.

  As shown in Fig. 3, a silicon human real large nasal cavity model (nasal cavity transparent model LM-005, KOKEN CO., LTD) is connected to an air pump via a vinyl hose simulating the trachea. The evening was attached near the ear canal. The side of the nasal cavity model was closed with an acrylic board that resembled the nasal septum. The pressure in the nasal cavity can be adjusted by changing the air suction force of the air pump.

  As shown in FIGS. 26 (A), (B), and (C), the nasal spray is inserted into the nostril of the nasal cavity model at three angles of 20 °, 40 °, and 60 ° with respect to the horizontal plane, Sprayed. The spraying was performed manually with a nasal spray nozzle fixed with a manipulator. In addition, in order to perform a spray experiment (spray test in a state simulating a human nasal slide) assuming actual use, the pressure near the ear canal at the time of spraying is 0 kPa, −2.4 kPa, −5.8 kPa. The following three conditions were used.

  As a result, as shown in FIGS. 26 (A), 26 (B), and 26 (C), when the insertion angle of the nasal spray is 20 ° [FIG. 26 (A)], the medicine hits the affected area, but it is assumed at the time of actual use. At 40 ° [FIG. 26 (B)] and 60 ° [FIG. 26 (C)], almost no contact was found on the affected area, and many adhered to other than the affected area. In addition, when the insertion angle is 20 ° (A), it is not practical because it is out of the angle at which it is actually inserted into the nasal cavity, and the medicinal solution can be sprayed only to a part of the lower turbinate.

  In addition, in the test simulating nasal slide, especially when the insertion angle of the spray is 40 ° and 60 °, the drug flows to the upper part of the nasal cavity due to inhalation of air and adheres to the upper part of the nasal cavity. Was not seen.

  In addition, using a high-speed camera (MEMRECAMfx-6000, NAC Image Technology Co., Ltd.), the instant of nasal spray was shot under the conditions of frame rate: 4000 frames / second and shutter speed: 1 / 10k. Then, when the behavior of the spray droplets was examined, the same result as above was confirmed.

  In addition, in order to investigate the effect of the viscosity of the drug, Avicel RC-A591NF (Asahi Kasei Chemicals Corporation) concentration of 0.5%, 1.0%, 1.5% Avicel RC water suspension was prepared, When each was placed in a drug container and sprayed in the same manner as described above, no clear difference was observed in the sprayed state due to the difference in viscosity.

Example 1
Using the nasal spray container having the nozzle tip shown in FIGS. 1 and 2 (inclination angle of the inclined channel leading to the spraying port: 30.9 ° with respect to the central axis of the spray), the same test as described above was performed. As a result, as shown in FIGS. 25A, 25B, and 25C, the drug solution could be efficiently sprayed onto the affected part (lower turbinate) at any insertion angle. In particular, even at normal insertion angles (40 ° and 60 °), the drug solution was able to adhere to a wide range of affected areas (such as the lower turbinate and its lower part). Further, in the spray test in a state of simulating nasal slide, the drug solution could be efficiently sprayed on the affected area as described above. 25A is a schematic diagram showing a spray state in spraying at an insertion angle of 20 °, FIG. 25B is an insertion angle of 40 °, and FIG. 25C is an insertion angle of 60 °.

Comparative Example 2 and Example 2
The spray used in Comparative Example 1 and Example 1 was fixed at an angle of 45 ° with respect to the horizontal plane, and the tip of the nozzle was inserted about 1 mm from the outer nostril and sprayed. The back of the nasal model was left open and the lower and nasal septum portions were closed.

  And the spray amount (adhesion amount of a chemical | medical solution) to the specific site | part (lower part of the lower nasal concha which is easy to cause inflammation by rhinitis) was measured as follows.

  For the spray amount Sw, the nasal cavity model is used, all parts are closed, the mass of the entire spray container is measured in advance with an electronic balance before spraying, and after spraying, the mass is similarly measured. did. In addition, in order to confirm the wiping error with a cotton swab, all parts were closed using a nasal cavity model, sprayed with a liquid agent, and attached to all parts (nasal cavity) with a cotton swab whose mass was measured in advance with an electronic balance (Mettler AT250 type). The liquid agent was wiped off, the mass of the cotton swab was measured, and the adhesion amount At was calculated. The difference (Sw-At) between the spray amount Sw and the mass At was defined as the wiping error amount. As a result, as shown in the table below, the entire amount of the sprayed liquid agent could not be wiped off with a cotton swab, resulting in a difference of about 7 mg (4.33 to 10.06).

  About the amount Aw of chemical solution attached to a specific part, after spraying the liquid, wipe the liquid attached to the specific part with a swab (commercially available product) whose mass was measured in advance, and measure the weight of the swab with an electronic balance (Mettler AT250 type) Measured and the increased mass was taken as the amount of adhesion. These operations were repeated five times for each of the three sprays used in Comparative Example 1 and Example 1, and average values were calculated. The results are shown in the table below.

  As is clear from the table, the spray state of the specific part is clearly different between the nozzle of the example and the nozzle of the comparative example, and the amount of the nozzle of the example is almost four times as much as that of the comparative example. Sprayed. In addition, in consideration of errors, 90% or more of the spraying by the nozzle of the embodiment is sprayed on the specific part.

Comparative Example 3 and Example 3
Using the spray container of Comparative Example 1 and the spray container of Example 1, the aqueous solution to which the edible red pigment was added was placed in each container and sprayed as follows to examine the spray pattern.

(1) Measurement of spray angle The nozzle tip was directed upward, the spray was fixed vertically, and paper was placed 30 mm above the nozzle tip and sprayed. The jetting angle was calculated from the situation where the chemical solution was attached to the paper.

  In Example 3, the center of the spray pattern (elliptical pattern) was 26 mm away from the nozzle axis at a position 30 mm above the nozzle, and was jetted at an angle of 30 ° with respect to the vertical direction. In Comparative Example 3, a ring-shaped spray pattern was obtained.

(2) Measurement of spray pattern The nozzle tip was directed upward, the spray was fixed vertically, and the nozzle was positioned at the hollow center of the hollow cylindrical paper tube for spraying. Three types of paper cylinders having an inner diameter of 38 mm, 45 mm, and 85 mm were used as the paper cylinders. The spray pattern was recorded from the situation in which the chemical solution adhered to the paper tube arranged on the inner peripheral wall (perpendicular to the concentric circle of the nozzle) of the paper tube.

  In addition, in the spray container of Comparative Example 3, there was much air mist in the measurement with a cylindrical diameter of 85 mm, and there was variation in the pattern on the circumference during the measurement. Moreover, it was sprayed on the ceiling part of the cylinder.

Example 4
In addition to the spray container having the nozzle tip of Comparative Example 1 and Example 1, the spray characteristics were examined using a spray container having the nozzle tip having the structure shown in FIG. In addition, an inclined flow path having an inner diameter of 0.3 mm was formed at an angle of 30.9 ° at the tip of the nozzle, and an inverted conical recess having an inner diameter of 1.6 mm was formed by a drill in the spray port region of the flow path.

  Then, the adhesion amount and the adhesion rate of the spray liquid to the specific part (the lower part of the nasal condyle) are measured in the same manner as described above, and the nozzle is held vertically as shown in FIG. Paper was set to L = 100 mm, the coloring liquid was sprayed, and the spray pattern was observed. As a result, the results shown in the following table and FIG. 27 were obtained.

  If the nozzle of Example 1 is used, it can spray to a specific site | part with high efficiency by narrow spray angle (theta) 1 (13.4 degrees). In addition, the spray pattern by the nozzle of Example 1 was an elliptical shape with a major axis diameter a = 38 mm. In addition, when the nozzle of Example 4 is used, the spray angle θ2 (30.2 °) can be expanded from the spray angle θ1 while reducing the droplet diameter without significantly reducing the spray amount to the specific part. In addition, the spray pattern by the nozzle of Example 4 was an elliptical shape with a major axis diameter b = 100 mm.

FIG. 1 is a schematic view showing a spray container of the present invention. 2 is a schematic cross-sectional view of the nozzle tip of the spray container shown in FIG. FIG. 3 is a schematic view showing a use state of the spray container shown in FIG. FIG. 4 is a schematic perspective view showing another example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing still another example of the spray container of the present invention. FIG. 6 is a schematic perspective view of the nozzle tip portion showing a modified example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing a modified example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing a modified example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing a modified example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing a modified example of the spray container of the present invention. FIG. 5 is a schematic perspective view of the nozzle tip showing a modified example of the spray container of the present invention. FIG. 12 is a schematic sectional view showing another example of the spray container of the present invention. FIG. 13 is a schematic sectional view showing still another example of the spray container of the present invention. FIG. 14 is a schematic sectional view showing another example of the spray container of the present invention. FIG. 15 is a schematic sectional view showing another example of the spray container of the present invention. FIG. 16 is a schematic sectional view showing still another example of the spray container of the present invention. FIG. 17 is a schematic view showing still another example of the spray container of the present invention. FIG. 18 is a schematic view showing still another example of the spray container of the present invention. FIG. 19 is a schematic view showing still another example of the spray container of the present invention. FIG. 20 is a schematic view showing still another example of the spray container of the present invention. FIG. 21 is a schematic view showing still another example of the spray container of the present invention. FIG. 22 is a schematic view showing still another example of the spray container of the present invention. FIG. 23 is a schematic view showing still another example of the spray container of the present invention. FIG. 24 is a schematic sectional view showing the nozzle tip of a conventional spray container. FIG. 25 is a schematic view showing a spray state in Example 1, FIG. 25A is an insertion angle of 20 °, FIG. 25B is an insertion angle of 40 °, and FIG. 25C is an insertion angle of 60 °. The spray state of is shown. FIG. 26 is a schematic view showing a spray state in Comparative Example 1, FIG. 26 (A) shows an insertion angle of 20 °, FIG. 26 (B) shows an insertion angle of 40 °, and FIG. 26 (C) shows an insertion angle of 60 °. The spray state of is shown. FIG. 27 is a schematic view showing a method in the fourth embodiment.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 ... Container main body 2 ... Immersion tube 3 ... 1st cylinder 5 ... Spring 8 ... Slide member 13 ... 2nd cylinder 15 ... Hollow stem 19, 79, 89, 109 ... Insert 20, 111, 113 ... Hanging Stop part 21 ... Annular flow path 24, 34, 74, 84, 94, 104 ... Spray port 23, 43-46, 73, 83, 93 ... Inclined flow path 25, 35, 70, 80, 90, 100, 110, 112 ... Nozzle

Claims (12)

  A spray container comprising a hollow cylinder provided with a flow path for circulating a chemical solution, and a nozzle attached to the hollow cylinder and having a spray port formed at the tip thereof communicating with the flow path, A spray container in which the nozzle is capable of spraying a drug solution in an oblique direction with respect to the axis line by at least one of an inclination of an opening direction of the spray port with respect to the axis line and a deviation of a chemical flow rate at the spray port.   The spray container according to claim 1, wherein the flow path at the tip of the nozzle includes an inclined flow path that is inclined with respect to the axis and reaches the spray port.   A container main body having an accommodating portion for accommodating a chemical solution, a dip tube in which one end portion can be immersed in the chemical solution, and a first cylindrical body that holds the other end portion of the tube and contains a spring A slide member that is slidably disposed in the first cylindrical body and has a flow path for circulating a chemical solution from the first cylindrical body, and is movable forward and backward by a spring, and the slide member The spray container according to claim 1, further comprising: a second cylindrical body for guiding the chemical liquid from the flow path to the spray port at the tip of the nozzle as the slide member moves forward and backward.   The second cylindrical body is connected to the slide member and has a hollow stem having a flow path for guiding a chemical solution from the flow path of the slide member, and a hook connected to the stem and capable of hooking a finger. The spray according to claim 3, comprising an outer cylinder having a stop portion and an insert disposed in the outer cylinder and forming an annular flow path between the downstream end of the stem and the spray port. container.   A plurality of protrusions extending in the axial direction at intervals in the circumferential direction and slidable in the outer cylinder are formed in the upstream portion of the insert, and the width of the annular flow path from the downstream end of these protrusions is The spray container according to claim 4, which is small.   The spray container according to claim 1, wherein the inclined channel is inclined at an angle of 15 to 45 ° with respect to the axis.   The spray container according to claim 1, wherein a recess is formed at the tip of the nozzle, and the spray port is opened at the recess.   The spray container according to claim 1, wherein at least a tip portion of the nozzle is radially shifted from the axis or inclined.   The spray container according to claim 1, wherein the nozzle tip has an inclined surface inclined with respect to the axis, and the spray port is opened in an oblique direction on the inclined surface.   The spray container according to claim 1, which is for nasal drop.   The spray container according to claim 1, wherein notification means is provided for indicating the spray direction of the chemical liquid.   A method of spraying a chemical using the spray container according to claim 1, wherein the chemical is sprayed in an oblique direction while reducing a spray area of the chemical.

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