TW202214608A - 稠合噠嗪類衍生物、其製備方法及其在醫藥上的應用 - Google Patents

稠合噠嗪類衍生物、其製備方法及其在醫藥上的應用 Download PDF

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Publication number
TW202214608A
TW202214608A TW110126621A TW110126621A TW202214608A TW 202214608 A TW202214608 A TW 202214608A TW 110126621 A TW110126621 A TW 110126621A TW 110126621 A TW110126621 A TW 110126621A TW 202214608 A TW202214608 A TW 202214608A
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TW
Taiwan
Prior art keywords
alkyl
cancer
cycloalkyl
haloalkyl
heterocyclyl
Prior art date
Application number
TW110126621A
Other languages
English (en)
Chinese (zh)
Inventor
李心
陳陽
王斌
賀峰
陶維康
Original Assignee
大陸商江蘇恆瑞醫藥股份有限公司
大陸商上海恆瑞醫藥有限公司
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Publication date
Application filed by 大陸商江蘇恆瑞醫藥股份有限公司, 大陸商上海恆瑞醫藥有限公司 filed Critical 大陸商江蘇恆瑞醫藥股份有限公司
Publication of TW202214608A publication Critical patent/TW202214608A/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
TW110126621A 2020-07-20 2021-07-20 稠合噠嗪類衍生物、其製備方法及其在醫藥上的應用 TW202214608A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CN202010701561.X 2020-07-20
CN202010701561 2020-07-20
CN202011495424.1 2020-12-17
CN202011495424 2020-12-17

Publications (1)

Publication Number Publication Date
TW202214608A true TW202214608A (zh) 2022-04-16

Family

ID=79728964

Family Applications (1)

Application Number Title Priority Date Filing Date
TW110126621A TW202214608A (zh) 2020-07-20 2021-07-20 稠合噠嗪類衍生物、其製備方法及其在醫藥上的應用

Country Status (2)

Country Link
TW (1) TW202214608A (fr)
WO (1) WO2022017339A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019217307A1 (fr) 2018-05-07 2019-11-14 Mirati Therapeutics, Inc. Inhibiteurs de kras g12c
EP3908283A4 (fr) 2019-01-10 2022-10-12 Mirati Therapeutics, Inc. Inhibiteurs de kras g12c
JP2022546043A (ja) 2019-08-29 2022-11-02 ミラティ セラピューティクス， インコーポレイテッド Ｋｒａｓ ｇ１２ｄ阻害剤
MX2022003537A (es) 2019-09-24 2022-07-11 Mirati Therapeutics Inc Terapias de combinacion.
MX2022007515A (es) 2019-12-20 2022-09-19 Mirati Therapeutics Inc Inhibidores de sos1.
EP4319757A1 (fr) 2021-04-09 2024-02-14 Boehringer Ingelheim International GmbH Thérapie anticancéreuse
WO2023280317A1 (fr) * 2021-07-09 2023-01-12 南京明德新药研发有限公司 Composé benzylamino tricyclique et son utilisation
CN117677398A (zh) 2021-07-27 2024-03-08 东丽株式会社 用于癌的治疗和/或预防的药品
WO2023135260A1 (fr) 2022-01-14 2023-07-20 Jazz Pharmaceuticals Ireland Limited Nouveaux phtalazines à substitution amine et dérivés utilisés comme inhibiteurs de sos1
GB202203976D0 (en) * 2022-03-22 2022-05-04 Jazz Pharmaceuticals Ireland Ltd Tricyclic phthalazines and derivatives as sos1 inhibitors
CN114621186A (zh) * 2022-05-12 2022-06-14 上海维申医药有限公司 作为ras信号通路调控剂的杂环化合物
WO2024022507A1 (fr) * 2022-07-29 2024-02-01 江苏恒瑞医药股份有限公司 Composition pharmaceutique comprenant un inhibiteur de kras g12d
WO2024074827A1 (fr) 2022-10-05 2024-04-11 Sevenless Therapeutics Limited Nouveaux traitements de la douleur

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7759337B2 (en) * 2005-03-03 2010-07-20 Amgen Inc. Phthalazine compounds and methods of use
HUE056777T2 (hu) * 2016-12-22 2022-03-28 Amgen Inc Benzizotiazol-, izotiazolo[3,4-b]piridin-, kinazolin-, ftálazin-, pirido[2,3-d]piridazin- és pirido[2,3-d]pirimidin-származékok mint KRAS G12C inhibitorok tüdõ-, hasnyálmirigy- vagy vastagbélrák kezelésére
EP3558979B1 (fr) * 2016-12-22 2021-02-17 Boehringer Ingelheim International GmbH Nouvelles quinazolines substituées benzylamino et dérivés en tant qu'inhibiteurs de sos1
MX2022007515A (es) * 2019-12-20 2022-09-19 Mirati Therapeutics Inc Inhibidores de sos1.

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