TW202144331A - 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 - Google Patents
作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 Download PDFInfo
- Publication number
- TW202144331A TW202144331A TW110104876A TW110104876A TW202144331A TW 202144331 A TW202144331 A TW 202144331A TW 110104876 A TW110104876 A TW 110104876A TW 110104876 A TW110104876 A TW 110104876A TW 202144331 A TW202144331 A TW 202144331A
- Authority
- TW
- Taiwan
- Prior art keywords
- methyl
- hex
- compound
- compounds
- azabicyclo
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20157257 | 2020-02-13 | ||
| EP20157257.5 | 2020-02-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW202144331A true TW202144331A (zh) | 2021-12-01 |
Family
ID=69591570
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW110104876A TW202144331A (zh) | 2020-02-13 | 2021-02-09 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11851418B2 (https=) |
| EP (1) | EP4103561A1 (https=) |
| JP (1) | JP7686002B2 (https=) |
| CN (1) | CN115087652B (https=) |
| AR (1) | AR121340A1 (https=) |
| TW (1) | TW202144331A (https=) |
| WO (1) | WO2021160716A1 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112839711A (zh) | 2018-10-10 | 2021-05-25 | 勃林格殷格翰国际有限公司 | 作为血浆激肽释放酶抑制剂的苯基四唑衍生物 |
| TWI873290B (zh) | 2020-02-13 | 2025-02-21 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TW202144331A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI243164B (en) | 2001-02-13 | 2005-11-11 | Aventis Pharma Gmbh | Acylated indanyl amines and their use as pharmaceuticals |
| US20050090529A1 (en) | 2003-07-31 | 2005-04-28 | Pfizer Inc | 3,5 Disubstituted indazole compounds with nitrogen-bearing 5-membered heterocycles, pharmaceutical compositions, and methods for mediating or inhibiting cell proliferation |
| JP2005089362A (ja) | 2003-09-17 | 2005-04-07 | Sumitomo Chemical Co Ltd | アリールピラゾリン化合物及びその用途 |
| EP2259679A4 (en) | 2008-01-31 | 2011-09-14 | Joslin Diabetes Ct | METHODS OF TREATING KALLIKREIN RELATED DISORDERS |
| EP2807156A1 (en) | 2012-01-27 | 2014-12-03 | Novartis AG | Aminopyridine derivatives as plasma kallikrein inhibitors |
| US20140378474A1 (en) | 2012-01-27 | 2014-12-25 | Novartis Ag | 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| EP2999697B1 (en) | 2013-05-23 | 2017-04-19 | Kalvista Pharmaceuticals Limited | Heterocyclic derivates |
| KR102736869B1 (ko) * | 2014-03-07 | 2024-12-02 | 바이오크리스트파마슈티컬즈,인코포레이티드 | 인간 혈장 칼리크레인 저해제 |
| GB201421083D0 (en) * | 2014-11-27 | 2015-01-14 | Kalvista Pharmaceuticals Ltd | Enzyme inhibitors |
| DK4019022T3 (en) * | 2015-10-01 | 2024-02-19 | Biocryst Pharm Inc | Human plasma kallikrein inhibitors |
| WO2017072020A1 (en) | 2015-10-27 | 2017-05-04 | Boehringer Ingelheim International Gmbh | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| EP3368524B1 (en) | 2015-10-27 | 2021-08-18 | Boehringer Ingelheim International GmbH | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| DK3464271T3 (da) | 2016-05-31 | 2020-06-15 | Kalvista Pharmaceuticals Ltd | Pyrazolderivater som plasma-kallikreininhibitorer |
| CN110022875A (zh) | 2016-07-11 | 2019-07-16 | 莱福斯希医药公司 | 治疗性抑制化合物 |
| US10501440B2 (en) | 2017-04-21 | 2019-12-10 | Boehringer Ingelheim International Gmbh | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors |
| JP6828191B2 (ja) * | 2018-08-16 | 2021-02-10 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 血漿カリクレイン阻害剤としての複素芳香族カルボキサミド誘導体 |
| DK4031547T3 (da) * | 2019-09-18 | 2024-09-09 | Takeda Pharmaceuticals Co | Plasmakallikreininhibitorer og anvendelser deraf |
| TW202144331A (zh) | 2020-02-13 | 2021-12-01 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
| TWI873290B (zh) | 2020-02-13 | 2025-02-21 | 德商百靈佳殷格翰國際股份有限公司 | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 |
-
2021
- 2021-02-09 TW TW110104876A patent/TW202144331A/zh unknown
- 2021-02-11 US US17/173,212 patent/US11851418B2/en active Active
- 2021-02-11 EP EP21704539.2A patent/EP4103561A1/en active Pending
- 2021-02-11 WO PCT/EP2021/053284 patent/WO2021160716A1/en not_active Ceased
- 2021-02-11 JP JP2022548997A patent/JP7686002B2/ja active Active
- 2021-02-11 CN CN202180014104.6A patent/CN115087652B/zh active Active
- 2021-02-12 AR ARP210100384A patent/AR121340A1/es not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| AR121340A1 (es) | 2022-05-11 |
| EP4103561A1 (en) | 2022-12-21 |
| CN115087652A (zh) | 2022-09-20 |
| CN115087652B (zh) | 2024-05-07 |
| US20210276976A1 (en) | 2021-09-09 |
| JP2023513906A (ja) | 2023-04-04 |
| WO2021160716A1 (en) | 2021-08-19 |
| JP7686002B2 (ja) | 2025-05-30 |
| US11851418B2 (en) | 2023-12-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3368529B1 (en) | Heteroarylcarboxamide derivatives as plasma kallikrein inhibitors | |
| JP7703587B2 (ja) | 血漿カリクレイン阻害剤としての複素芳香族カルボキシアミド誘導体 | |
| JP6828191B2 (ja) | 血漿カリクレイン阻害剤としての複素芳香族カルボキサミド誘導体 | |
| JP7175914B2 (ja) | 血漿カリクレイン阻害剤としてのヘテロアリールカルボキサミド誘導体 | |
| JP2018535963A (ja) | 血漿カリクレイン阻害薬としてのヘテロアリールカルボキサミド誘導体 | |
| TW202144331A (zh) | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 | |
| JP2022541065A (ja) | 炎症性気道疾患又は線維性疾患の治療のためのオートタキシン（ａｔｘ）モジュレーターとしてのｎ－メチル，ｎ－（６－（メトキシ）ピリダジン－３－イル）アミン誘導体 | |
| JP7378470B2 (ja) | 血漿カリクレイン阻害剤としてのフェニルテトラゾール誘導体 | |
| TW202233592A (zh) | 作為血漿激肽釋放酶抑制劑之雜芳族甲醯胺衍生物 | |
| BR122025021106A2 (pt) | Compostos derivados de carboxamida heteroaromáticos como inibidores da calicreína plasmática, sal dos mesmos, composição farmacêutica compreendendo os mesmos, e seus usos | |
| TW202237620A (zh) | 作為血小板活化因子受體拮抗劑之環戊烷并噻吩甲醯胺衍生物 | |
| EA049265B1 (ru) | Гетероароматические карбоксамидные производные в качестве ингибиторов калликреина плазмы |